MCID: LCT003
MIFTS: 30

Lactocele

Categories: Cancer diseases, Endocrine diseases, Rare diseases
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Aliases & Classifications for Lactocele

MalaCards integrated aliases for Lactocele:

Name: Lactocele 11 19 14 75
Galactocele 11 19 43 75
Galactocoele 19 75
Lacteal Cyst 19

Classifications:



External Ids:

Disease Ontology 11 DOID:10686
ICD9CM 34 611.5
MeSH 43 C535998
NCIt 49 C3515
SNOMED-CT 68 42385006
UMLS 71 C0152243

Summaries for Lactocele

Disease Ontology: 11 A breast cyst that develops during or shortly after lactation and is characterized by retention of milk or a milky substance that is usually located in the mammary glands.

MalaCards based summary: Lactocele, also known as galactocele, is related to breast abscess and hyperprolactinemia. An important gene associated with Lactocele is PRL (Prolactin), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Affiliated tissues include mammary glands and breast, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia: 75 A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky... more...

Related Diseases for Lactocele

Diseases related to Lactocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 breast abscess 30.3 PRL OXT
2 hyperprolactinemia 30.0 TRH PRL GHRH
3 hypogonadism 29.6 PRL LHCGR KISS1
4 hypogonadotropic hypogonadism 29.6 PRL LHCGR KISS1
5 hypopituitarism 29.3 TRH PRL GHRH
6 hypothyroidism 29.3 TRH PRL GHRH
7 congenital hypothyroidism 29.3 TRH PRL GHRH
8 adenoma 29.0 TRH PRL LHCGR GHRH
9 galactorrhea 10.3
10 diabetes insipidus 10.2 PRL OXT
11 hypoactive sexual desire disorder 10.2 PRL OXT
12 pedophilia 10.2 PRL OXT
13 inhibited male orgasm 10.2 PRL OXT
14 sexual sadism 10.2 PRL OXT
15 sexual health disorder 10.2 PRL OXT
16 leydig cell hypoplasia type ii 10.2 PRL LHCGR
17 inappropriate adh syndrome 10.2 PRL OXT
18 postpartum depression 10.2 PRL OXT
19 social phobia 10.1 PRL OXT
20 antisocial personality disorder 10.1 PRL OXT
21 tuberculum sellae meningioma 10.1 PRL GHRH
22 sella turcica neoplasm 10.1 PRL GHRH
23 uterine benign neoplasm 10.1 PRL OXT
24 reproductive organ benign neoplasm 10.1 PRL OXT
25 gangliocytoma 10.1 PRL GHRH
26 leydig cell tumor 10.1 PRL LHCGR
27 pituitary hypoplasia 10.1 PRL GHRH
28 hormone producing pituitary cancer 10.1 PRL GHRH
29 pituitary cancer 10.1 PRL GHRH
30 serotonin syndrome 10.1 OXT GHRH
31 lissencephaly, x-linked, 2 10.1 PRL GHRH
32 precocious puberty, male-limited 10.0 LHCGR KISS1
33 mastitis 10.0
34 gynecomastia 10.0
35 cystic echinococcosis 10.0
36 echinococcosis 10.0
37 breast fibroadenoma 10.0
38 breast disease 10.0
39 prolactinoma 10.0
40 supernumerary breasts 10.0
41 fibrous dysplasia 10.0 PRL GHRH
42 mccune-albright syndrome 10.0 PRL GHRH
43 acidophil adenoma 10.0 TRH PRL
44 chromophobe adenoma 10.0 TRH PRL
45 psychosexual disorder 10.0 PRL OXT KISS1
46 mixed cerebral palsy 10.0 TRH PRL
47 sheehan syndrome 10.0 TRH PRL
48 hypothyroidism, central, with testicular enlargement 9.9 TRH PRL
49 carney complex variant 9.9 PRL GHRH
50 acth deficiency, isolated 9.9 TRH PRL

Graphical network of the top 20 diseases related to Lactocele:



Diseases related to Lactocele

Symptoms & Phenotypes for Lactocele

MGI Mouse Phenotypes related to Lactocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 DAB2 GHRH KISS1 LHCGR MMP11 OXT
2 renal/urinary system MP:0005367 9.55 DAB2 KISS1 LHCGR OXT TRH
3 endocrine/exocrine gland MP:0005379 9.1 GHRH KISS1 LHCGR OXT PRL TRH

Drugs & Therapeutics for Lactocele

Search Clinical Trials, NIH Clinical Center for Lactocele

Cochrane evidence based reviews: galactocele

Genetic Tests for Lactocele

Anatomical Context for Lactocele

Organs/tissues related to Lactocele:

FMA: Mammary Glands
MalaCards : Breast

Publications for Lactocele

Articles related to Lactocele:

(show top 50) (show all 120)
# Title Authors PMID Year
1
Breast hydatid cyst presented as a fluctuant painless lump mimicking galactocele: A case report. 62
36356796 2022
2
A rare case of persistent large cystic breast tumor mimicking as malignant cystic breast cancer. 62
36412448 2022
3
Maintaining Breastfeeding During the Treatment of Breast Abscesses Is Not Contraindicated. 62
36121389 2022
4
Crystallizing galactocele of the breast masquerading as a malignancy: Report of a rare case with cytological diagnosis. 62
35488729 2022
5
Acute Quadriplegia in a Lactating Woman With Mastitis and Breast Abscess. 62
35236167 2022
6
Nipple Eczema Causing Galactorrhea by Reactive Hyperprolactinemia, Complicated by a Galactocele. 62
35059599 2022
7
Re-thinking benign inflammation of the lactating breast: Classification, prevention, and management. 62
35441543 2022
8
Postpartum Galactocele in Augmented Breast after Using Breast Pump Mimicking Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report. 62
36238888 2021
9
Management of Infected Galactocele and Breast Implant with Uninterrupted Breastfeeding. 62
34804762 2021
10
Does Male Infantile Galactocele Always Necessitate Surgical Intervention? 62
34667677 2021
11
Crystallising galactocele of the breast: a rare cytological diagnosis. 62
34035028 2021
12
Galactorrhea and Galactocele after Breast Augmentation: Diagnosis and Treatment Algorithm. 62
33885442 2021
13
Giant lactating adenoma. 62
33968827 2021
14
The Importance of Clinical Data for the Diagnosis of Breast Tumours in North Afghanistan. 62
34373791 2021
15
Hyperechoic Lesions on Breast Ultrasound: All Things Bright and Beautiful? 62
34316107 2021
16
Galactorrhea/Galactocele After Breast Augmentation: A Systematic Review. 62
32079808 2021
17
Pregnancy-lactation cycle: how to use imaging methods for breast evaluation. 62
33304009 2020
18
FNAC Diagnosis of Crystallizing Galactocele- An Unusual Presentation. 62
33088035 2020
19
Benign Disorders of the Breast in Pregnancy and Lactation. 62
32816261 2020
20
Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation. 62
30456639 2019
21
Breastfeeding pathologies: analysis of prevalence, risk and protective factors. 62
30977749 2019
22
Galactocele of adult male breast: A cytopathologist's perspective. 62
30461216 2019
23
Recurrent complications of PAAG implants during lactation. 62
30396888 2018
24
Crystallizing Galactocele: A rare entity-report of two cases. 62
30144343 2018
25
Galactocele, Pitfall for the Evaluation by 18F-FDG PET/CT. 62
29847317 2018
26
Hyperechoic breast images: all that glitters is not gold! 62
29476429 2018
27
Cytological diagnosis of crystallizing galactocele - report of an unusual case. 62
29286912 2018
28
Galactocele in a Prepubertal Girl. 62
28126385 2017
29
Galactocele in the Axillary Accessory Breast Mimicking Suspicious Solid Mass on Ultrasound. 62
28487794 2017
30
Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells. 62
27708194 2017
31
[A rare case of giant galactocele associated with prolactinoma]. 62
28819518 2017
32
Crystallizing galactocele: Report of a rare variation. 62
27662275 2016
33
Chronic Galactocele. 62
27124312 2016
34
Erratum: Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy: Erratum. 62
27579220 2016
35
Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy. 62
27257574 2016
36
Galactocele in a Male Infant with Transient Hyperprolactinaemia: An Extremely Rare Cause of Breast Enlargement in Children. 62
27752383 2016
37
[Rare benign breast tumors including Abrikossoff tumor (granular cell tumor), erosive adenomatosis of the nipple, cytosteatonecrosis, fibromatosis (desmoid tumor), galactocele, hamartoma, hemangioma, lipoma, juvenile papillomatosis, pseudoangiomatous hyperplasia, and syringomatous adenoma: Guidelines for clinical practice]. 62
26530177 2015
38
Breast lumps in pregnant women. 62
26341843 2015
39
Diagnosis and management of galactorrhea after breast augmentation. 62
25919249 2015
40
Primary hydatid disease of the breast clinically masquerading as a galactocele: A case report. 62
27847893 2015
41
[Lactation after breast plastic surgery: literature review]. 62
25147123 2015
42
Unilateral galactocele in a male infant. 62
25831914 2015
43
Digital breast tomosynthesis in the analysis of fat-containing lesions. 62
24617683 2014
44
Bilateral galactocele in a male infant with Down syndrome and congenital hypothyroidism. 62
24134763 2013
45
Peri-implant galactocele following vacuum-assisted core biopsy of the breast: a cautionary tale. 62
23749817 2013
46
Postaugmentation galactocele. 62
23629139 2013
47
Crystallizing galactocele - an unusual diagnosis on fine needle aspiration cytology. 62
23634434 2013
48
Echogenic breast masses at US: to biopsy or not to biopsy? 62
23479705 2013
49
Clinicopathologic profile of benign breast conditions in Indian women: prospective study based on aberrations of normal development and involution classification. 62
22744217 2012
50
Polyacrylamide hydrogel injection for augmentation mammaplasty: loss of ability for breastfeeding. 62
21785335 2012

Variations for Lactocele

Expression for Lactocele

Search GEO for disease gene expression data for Lactocele.

Pathways for Lactocele

Pathways related to Lactocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 TRH OXT LHCGR KISS1 GHRH
2
Show member pathways
12.48 TRH OXT LHCGR KISS1 GHRH
3 10.58 OXT KISS1 GHRH

GO Terms for Lactocele

Biological processes related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eating behavior GO:0042755 9.62 TRH OXT
2 response to food GO:0032094 9.46 OXT GHRH
3 response to steroid hormone GO:0048545 9.43 OXT DAB2
4 positive regulation of synaptic transmission GO:0050806 9.26 OXT KISS1
5 positive regulation of growth hormone secretion GO:0060124 8.92 KISS1 GHRH

Molecular functions related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.26 OXT GHRH
2 hormone activity GO:0005179 9.02 TRH PRL OXT GHRH

Sources for Lactocele

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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