MCID: LCT003
MIFTS: 30

Lactocele

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Lactocele

MalaCards integrated aliases for Lactocele:

Name: Lactocele 12 20 15
Galactocele 12 20 44
Galactocoele 20
Lacteal Cyst 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10686
ICD9CM 34 611.5
MeSH 44 C535998
NCIt 50 C3515
SNOMED-CT 67 42385006
ICD10 32 N64.89
UMLS 70 C0152243

Summaries for Lactocele

Disease Ontology : 12 A breast cyst that develops during or shortly after lactation and is characterized by retention of milk or a milky substance that is usually located in the mammary glands.

MalaCards based summary : Lactocele, also known as galactocele, is related to hyperprolactinemia and pituitary adenoma, prolactin-secreting. An important gene associated with Lactocele is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways is Peptide ligand-binding receptors. Affiliated tissues include mammary glands, breast and pituitary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 73 A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky... more...

Related Diseases for Lactocele

Diseases related to Lactocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 hyperprolactinemia 29.8 TRH PRL GHRH
2 pituitary adenoma, prolactin-secreting 29.5 TRH PRL
3 hypopituitarism 29.3 TRH PRL GHRH
4 hypothyroidism 29.2 TRH PRL GHRH
5 adenoma 28.9 TRH PRL LHCGR GHRH
6 diabetes insipidus 10.2 PRL OXT
7 pedophilia 10.2 PRL OXT
8 sexual sadism 10.2 PRL OXT
9 psychosexual disorder 10.2 PRL OXT
10 sexual disorder 10.2 PRL OXT
11 galactorrhea 10.2
12 inhibited female orgasm 10.2 PRL OXT
13 antisocial personality disorder 10.1 PRL OXT
14 social phobia 10.1 PRL OXT
15 uterine benign neoplasm 10.1 PRL OXT
16 reproductive organ benign neoplasm 10.1 PRL OXT
17 postpartum depression 10.1 PRL OXT
18 tuberculum sellae meningioma 10.1 PRL GHRH
19 sella turcica neoplasm 10.1 PRL GHRH
20 prolactin producing pituitary tumor 10.1 PRL GHRH
21 gigantism 10.1 PRL GHRH
22 adenomyosis 10.1 PRL OXT
23 hormone producing pituitary cancer 10.1 PRL GHRH
24 gangliocytoma 10.1 PRL GHRH
25 serotonin syndrome 10.1 OXT GHRH
26 pituitary carcinoma 10.1 PRL GHRH
27 leydig cell tumor 10.1 PRL LHCGR
28 growth hormone secreting pituitary adenoma 10.0 PRL GHRH
29 fibrous dysplasia 10.0 PRL GHRH
30 disorder of sexual development 10.0 PRL LHCGR
31 breast abscess 10.0
32 infant gynecomastia 10.0
33 gynecomastia 10.0
34 breast fibroadenoma 10.0
35 breast disease 10.0
36 carney complex variant 10.0 PRL GHRH
37 pseudohypoparathyroidism 10.0 TRH PRL
38 generalized resistance to thyroid hormone 10.0 TRH PRL
39 adenohypophysitis 10.0 TRH PRL
40 acidophil adenoma 9.9 TRH PRL
41 chromophobe adenoma 9.9 TRH PRL
42 mixed cerebral palsy 9.9 TRH PRL
43 hypothyroidism, central, with testicular enlargement 9.9 TRH PRL
44 insulin-like growth factor i 9.9 PRL GHRH
45 anorexia nervosa 9.9 PRL OXT GHRH
46 empty sella syndrome 9.9 TRH PRL
47 acth deficiency, isolated 9.9 TRH PRL
48 melancholia 9.9 TRH PRL
49 lipomatosis, multiple 9.8
50 down syndrome 9.8

Graphical network of the top 20 diseases related to Lactocele:



Diseases related to Lactocele

Symptoms & Phenotypes for Lactocele

MGI Mouse Phenotypes related to Lactocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 COL5A3 GHRH LHCGR OXT PRL TRH
2 homeostasis/metabolism MP:0005376 9.17 COL5A3 DAB2 GHRH LHCGR OXT PRL

Drugs & Therapeutics for Lactocele

Search Clinical Trials , NIH Clinical Center for Lactocele

Cochrane evidence based reviews: galactocele

Genetic Tests for Lactocele

Anatomical Context for Lactocele

The Foundational Model of Anatomy Ontology organs/tissues related to Lactocele:

19
Mammary Glands

MalaCards organs/tissues related to Lactocele:

40
Breast, Pituitary, Thyroid, Heart, Kidney, Tongue

Publications for Lactocele

Articles related to Lactocele:

(show top 50) (show all 98)
# Title Authors PMID Year
1
Galactorrhea/Galactocele After Breast Augmentation: A Systematic Review. 61
32079808 2021
2
Pregnancy-lactation cycle: how to use imaging methods for breast evaluation. 61
33304009 2020
3
FNAC Diagnosis of Crystallizing Galactocele- An Unusual Presentation. 61
33088035 2020
4
Benign Disorders of the Breast in Pregnancy and Lactation. 61
32816261 2020
5
Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation. 61
30456639 2019
6
Breastfeeding pathologies: analysis of prevalence, risk and protective factors. 61
30977749 2019
7
Galactocele of adult male breast: A cytopathologist's perspective. 61
30461216 2019
8
Crystallizing Galactocele: A rare entity-report of two cases. 61
30144343 2018
9
Galactocele, Pitfall for the Evaluation by 18F-FDG PET/CT. 61
29847317 2018
10
Hyperechoic breast images: all that glitters is not gold! 61
29476429 2018
11
Cytological diagnosis of crystallizing galactocele - report of an unusual case. 61
29286912 2018
12
Galactocele in a Prepubertal Girl. 61
28126385 2017
13
Galactocele in the Axillary Accessory Breast Mimicking Suspicious Solid Mass on Ultrasound. 61
28487794 2017
14
Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells. 61
27708194 2017
15
[A rare case of giant galactocele associated with prolactinoma]. 61
28819518 2017
16
Crystallizing galactocele: Report of a rare variation. 61
27662275 2016
17
Chronic Galactocele. 61
27124312 2016
18
Erratum: Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy: Erratum. 61
27579220 2016
19
Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy. 61
27257574 2016
20
Galactocele in a Male Infant with Transient Hyperprolactinaemia: An Extremely Rare Cause of Breast Enlargement in Children. 61
27752383 2016
21
[Rare benign breast tumors including Abrikossoff tumor (granular cell tumor), erosive adenomatosis of the nipple, cytosteatonecrosis, fibromatosis (desmoid tumor), galactocele, hamartoma, hemangioma, lipoma, juvenile papillomatosis, pseudoangiomatous hyperplasia, and syringomatous adenoma: Guidelines for clinical practice]. 61
26530177 2015
22
Breast lumps in pregnant women. 61
26341843 2015
23
Diagnosis and management of galactorrhea after breast augmentation. 61
25919249 2015
24
Primary hydatid disease of the breast clinically masquerading as a galactocele: A case report. 61
27847893 2015
25
Unilateral galactocele in a male infant. 61
25831914 2015
26
[Lactation after breast plastic surgery: literature review]. 61
25147123 2015
27
Digital breast tomosynthesis in the analysis of fat-containing lesions. 61
24617683 2014
28
Bilateral galactocele in a male infant with Down syndrome and congenital hypothyroidism. 61
24134763 2013
29
Peri-implant galactocele following vacuum-assisted core biopsy of the breast: a cautionary tale. 61
23749817 2013
30
Postaugmentation galactocele. 61
23629139 2013
31
Echogenic breast masses at US: to biopsy or not to biopsy? 61
23479705 2013
32
Crystallizing galactocele - an unusual diagnosis on fine needle aspiration cytology. 61
23634434 2013
33
Clinicopathologic profile of benign breast conditions in Indian women: prospective study based on aberrations of normal development and involution classification. 61
22744217 2012
34
Polyacrylamide hydrogel injection for augmentation mammaplasty: loss of ability for breastfeeding. 61
21785335 2012
35
Late seroma during pregnancy, a rare complication in prosthetic breast augmentation: case report. 61
22119792 2012
36
Galactocele in male infants: report of two cases and review of the literature. 61
22570125 2012
37
Postaugmentation galactocele: a case report and review of literature. 61
21346529 2011
38
Late hematoma, seroma, and galactocele in breasts injected with polyacrylamide gel. 61
21072516 2011
39
The galactocele of male infants: an intriguing entity. Study and reflection about a case, with review of the literature. 61
20718614 2011
40
Large unilateral breast autoinflation after breastfeeding linked to polyacrylamide hydrogel injection augmentation mammaplasty. 61
20652566 2011
41
Xanthogranulomatous reaction to a ruptured galactocele. 61
20202042 2010
42
Fine needle aspiration of breast masses in HIV-infected patients: results from a large series. 61
20572291 2010
43
Galactocele: an unusual cause of breast enlargement in children. 61
19573643 2009
44
Discrepant cytologic and radiographic findings in adjacent galactocele and fibroadenoma: a case report. 61
19365978 2009
45
Hyperprolactinemia and galactocele formation after augmentation mammoplasty. 61
19158518 2009
46
Galactocele and prolactinoma--a pathogenic association? 61
19110385 2009
47
Persistent hyperprolactinemia and bilateral galactocele in a male infant. 61
19956638 2009
48
[Giant galactocele in a lactating woman]. 61
19084727 2008
49
A late complication of augmentation mammoplasty by polyacrylamide hydrogel injection: ultrasound and magnetic resonance imaging findings of huge galactocele formation in a puerperal woman with pathological correlation. 61
19054003 2008
50
Galactocele as a changing axillary lump in a pregnant woman. 61
17406878 2007

Variations for Lactocele

Expression for Lactocele

Search GEO for disease gene expression data for Lactocele.

Pathways for Lactocele

GO Terms for Lactocele

Cellular components related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.62 OXT GHRH

Biological processes related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.56 TRH OXT LHCGR GHRH
2 hormone-mediated signaling pathway GO:0009755 9.16 TRH LHCGR
3 eating behavior GO:0042755 8.96 TRH OXT
4 response to food GO:0032094 8.62 OXT GHRH

Molecular functions related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 OXT GHRH
2 hormone activity GO:0005179 8.92 TRH PRL OXT GHRH

Sources for Lactocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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