MCID: LCT003
MIFTS: 38

Lactocele

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Lactocele

MalaCards integrated aliases for Lactocele:

Name: Lactocele 12 54 15
Galactocele 12 54 45
Galactocoele 54
Lacteal Cyst 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10686
ICD9CM 36 611.5
MeSH 45 C535998
NCIt 51 C3515
SNOMED-CT 69 42385006
ICD10 34 N64.89
UMLS 74 C0152243

Summaries for Lactocele

Disease Ontology : 12 A breast cyst that develops during or shortly after lactation and is characterized by retention of milk or a milky substance that is usually located in the mammary glands.

MalaCards based summary : Lactocele, also known as galactocele, is related to hyperprolactinemia and jak3-deficient severe combined immunodeficiency. An important gene associated with Lactocele is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Affiliated tissues include the mammary gl, breast and pituitary, and related phenotypes are Decreased viability in HMC1.1 cells and immune system

Wikipedia : 77 A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky... more...

Related Diseases for Lactocele

Graphical network of the top 20 diseases related to Lactocele:



Diseases related to Lactocele

Symptoms & Phenotypes for Lactocele

GenomeRNAi Phenotypes related to Lactocele according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in HMC1.1 cells GR00105-A-0 8.62 JAK1 JAK3

MGI Mouse Phenotypes related to Lactocele:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD68 JAK1 JAK2 JAK3 LHCGR MT-ND2

Drugs & Therapeutics for Lactocele

Search Clinical Trials , NIH Clinical Center for Lactocele

Cochrane evidence based reviews: galactocele

Genetic Tests for Lactocele

Anatomical Context for Lactocele

The Foundational Model of Anatomy Ontology organs/tissues related to Lactocele:

20
The Mammary Gl

MalaCards organs/tissues related to Lactocele:

42
Breast, Pituitary, T Cells

Publications for Lactocele

Articles related to Lactocele:

(show top 50) (show all 52)
# Title Authors Year
1
Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation. ( 30456639 )
2019
2
Galactocele of adult male breast: A cytopathologist's perspective. ( 30461216 )
2019
3
Cytological diagnosis of crystallizing galactocele - report of an unusual case. ( 29286912 )
2018
4
Galactocele, Pitfall for the Evaluation by 18F-FDG PET/CT. ( 29847317 )
2018
5
Crystallizing Galactocele: A rare entity-report of two cases. ( 30144343 )
2018
6
Galactocele in a Prepubertal Girl. ( 28126385 )
2017
7
Galactocele in the Axillary Accessory Breast Mimicking Suspicious Solid Mass on Ultrasound. ( 28487794 )
2017
8
Chronic Galactocele. ( 27124312 )
2016
9
Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy. ( 27257574 )
2016
10
Erratum: Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy: Erratum. ( 27579220 )
2016
11
Crystallizing galactocele: Report of a rare variation. ( 27662275 )
2016
12
Galactocele in a Male Infant with Transient Hyperprolactinaemia: An Extremely Rare Cause of Breast Enlargement in Children. ( 27752383 )
2016
13
Unilateral galactocele in a male infant. ( 25831914 )
2015
14
Primary hydatid disease of the breast clinically masquerading as a galactocele: A case report. ( 27847893 )
2015
15
Crystallizing galactocele - an unusual diagnosis on fine needle aspiration cytology. ( 23634434 )
2013
16
Peri-implant galactocele following vacuum-assisted core biopsy of the breast: a cautionary tale. ( 23749817 )
2013
17
Bilateral galactocele in a male infant with Down syndrome and congenital hypothyroidism. ( 24134763 )
2013
18
Postaugmentation galactocele. ( 23629139 )
2013
19
Galactocele in male infants: report of two cases and review of the literature. ( 22570125 )
2012
20
Postaugmentation galactocele: a case report and review of literature. ( 21346529 )
2011
21
Late hematoma, seroma, and galactocele in breasts injected with polyacrylamide gel. ( 21072516 )
2011
22
The galactocele of male infants: an intriguing entity. Study and reflection about a case, with review of the literature. ( 20718614 )
2011
23
Xanthogranulomatous reaction to a ruptured galactocele. ( 20202042 )
2010
24
Persistent hyperprolactinemia and bilateral galactocele in a male infant. ( 19956638 )
2009
25
Galactocele and prolactinoma--a pathogenic association? ( 19110385 )
2009
26
Hyperprolactinemia and galactocele formation after augmentation mammoplasty. ( 19158518 )
2009
27
Galactocele: an unusual cause of breast enlargement in children. ( 19573643 )
2009
28
Discrepant cytologic and radiographic findings in adjacent galactocele and fibroadenoma: a case report. ( 19365978 )
2009
29
A late complication of augmentation mammoplasty by polyacrylamide hydrogel injection: ultrasound and magnetic resonance imaging findings of huge galactocele formation in a puerperal woman with pathological correlation. ( 19054003 )
2008
30
Galactocele as a changing axillary lump in a pregnant woman. ( 17406878 )
2007
31
Galactocele in a male infant with congenital hypopituitarism. ( 15526725 )
2004
32
Galactocele of the breast in a postmenopausal woman. ( 15165774 )
2004
33
Infected galactocele: a perplexing problem. ( 15009047 )
2004
34
About images with breast implants and galactocele. ( 14663251 )
2003
35
Galactocele in a young male patient. ( 12832892 )
2003
36
A controlled trial of a new treatment for galactocele. ( 12757066 )
2003
37
Unilateral galactocele in a male infant. ( 11786855 )
2002
38
Bilateral galactocele in a male infant: a rare cause of gynecomastia in childhood. ( 11220699 )
2001
39
Galactocele: a rare cause of breast enlargement in an infant. ( 11547156 )
2001
40
Crystallizing galactocele. A case report. ( 9167716 )
1997
41
Unilateral galactocele following augmentation mammoplasty. ( 7944201 )
1994
42
Breastfeeding difficulties and a breast abscess associated with a galactocele: a case report. ( 8260035 )
1993
43
Galactocele in a male infant: case report and review of literature. ( 8516225 )
1993
44
Radiological case of the month. Galactocele. ( 1286987 )
1992
45
Galactocele of the breast: radiologic and ultrasonographic findings. ( 2178721 )
1990
46
Galactocele: three distinctive radiographic appearances. ( 3737931 )
1986
47
Galactocele: three distinctive radiographic appearances. ( 3940395 )
1986
48
Galactocele of the breast. ( 5011932 )
1972
49
Bilateral galactocele in a male infant. ( 6029470 )
1967
50
GALACTOCELE OF THE BREAST. ( 14215116 )
1964

Variations for Lactocele

Expression for Lactocele

Search GEO for disease gene expression data for Lactocele.

Pathways for Lactocele

Pathways related to Lactocele according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 JAK1 JAK2 JAK3 PRL TRIM21
2
Show member pathways
12.73 JAK1 JAK2 JAK3 PRL
3
Show member pathways
12.39 JAK1 JAK2 JAK3
4 12.36 JAK1 JAK2 JAK3
5
Show member pathways
12.33 JAK1 JAK2 TRIM21
6
Show member pathways
12.17 JAK1 JAK2 JAK3
7
Show member pathways
12.16 JAK1 JAK2 JAK3
8
Show member pathways
12.09 JAK1 JAK2 JAK3
9
Show member pathways
12.09 JAK1 JAK2 JAK3
10
Show member pathways
12.02 JAK1 JAK2 JAK3
11
Show member pathways
12.01 JAK1 JAK2 LHCGR PRL
12
Show member pathways
11.99 JAK1 JAK2 JAK3 PRL
13
Show member pathways
11.96 JAK1 JAK2 JAK3
14
Show member pathways
11.88 JAK1 JAK2 JAK3
15 11.83 JAK1 JAK2 JAK3
16
Show member pathways
11.8 JAK1 JAK2 JAK3
17
Show member pathways
11.77 JAK1 JAK2 JAK3
18
Show member pathways
11.66 JAK1 JAK2 JAK3
19 11.64 JAK1 JAK2 JAK3
20 11.55 JAK1 JAK2 JAK3
21 11.51 JAK1 JAK2
22
Show member pathways
11.51 JAK1 JAK2 JAK3
23
Show member pathways
11.5 JAK1 JAK3
24
Show member pathways
11.43 JAK1 JAK2
25 11.36 JAK2 PRL
26 11.33 JAK1 JAK2
27
Show member pathways
11.31 JAK1 JAK3
28 11.29 JAK1 JAK2
29
Show member pathways
11.27 JAK1 JAK2
30
Show member pathways
11.26 JAK1 JAK3
31
Show member pathways
11.25 JAK2 PRL
32
Show member pathways
11.21 JAK1 JAK2
33 11.18 JAK1 JAK2 JAK3
34 11.18 JAK1 JAK2
35 11.13 JAK1 JAK2 JAK3
36 11.01 JAK1 JAK3
37 10.82 JAK1 JAK2
38 10.79 JAK1 JAK2 JAK3
39 10.4 JAK1 JAK2 JAK3

GO Terms for Lactocele

Cellular components related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.46 CD68 JAK1 JAK3 LHCGR
2 endosome lumen GO:0031904 8.96 JAK2 PRL
3 endomembrane system GO:0012505 8.8 JAK1 JAK2 JAK3

Biological processes related to Lactocele according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.75 JAK1 JAK2 JAK3
2 MAPK cascade GO:0000165 9.74 JAK1 JAK2 JAK3
3 peptidyl-tyrosine phosphorylation GO:0018108 9.71 JAK1 JAK2 JAK3
4 hormone-mediated signaling pathway GO:0009755 9.6 JAK2 LHCGR
5 erythrocyte differentiation GO:0030218 9.59 JAK2 JAK3
6 interleukin-12-mediated signaling pathway GO:0035722 9.58 JAK1 JAK2
7 response to antibiotic GO:0046677 9.56 JAK1 JAK2
8 interleukin-7-mediated signaling pathway GO:0038111 9.55 JAK1 JAK3
9 interleukin-6-mediated signaling pathway GO:0070102 9.52 JAK1 JAK2
10 interleukin-15-mediated signaling pathway GO:0035723 9.51 JAK1 JAK3
11 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 JAK1 JAK2
12 interleukin-27-mediated signaling pathway GO:0070106 9.48 JAK1 JAK2
13 interleukin-2-mediated signaling pathway GO:0038110 9.46 JAK1 JAK3
14 interleukin-35-mediated signaling pathway GO:0070757 9.43 JAK1 JAK2
15 regulation of JAK-STAT cascade GO:0046425 9.4 JAK2 JAK3
16 interleukin-9-mediated signaling pathway GO:0038113 9.37 JAK1 JAK3
17 tyrosine phosphorylation of STAT protein GO:0007260 9.32 JAK2 JAK3
18 enzyme linked receptor protein signaling pathway GO:0007167 9.26 JAK2 JAK3
19 interleukin-21-mediated signaling pathway GO:0038114 9.16 JAK1 JAK3
20 interferon-gamma-mediated signaling pathway GO:0060333 9.13 JAK1 JAK2 TRIM21
21 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 JAK2 JAK3 PRL

Molecular functions related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.33 JAK1 JAK2 JAK3
2 growth hormone receptor binding GO:0005131 8.96 JAK1 JAK2
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.8 JAK1 JAK2 JAK3

Sources for Lactocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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