MCID: LCT003
MIFTS: 39

Lactocele

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Lactocele

MalaCards integrated aliases for Lactocele:

Name: Lactocele 12 53 15
Galactocele 12 53 44
Galactocoele 53
Lacteal Cyst 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10686
ICD10 33 N64.89
ICD9CM 35 611.5
MeSH 44 C535998
NCIt 50 C3515
SNOMED-CT 68 42385006
UMLS 73 C0152243

Summaries for Lactocele

Disease Ontology : 12 A breast cyst that develops during or shortly after lactation and is characterized by retention of milk or a milky substance that is usually located in the mammary glands.

MalaCards based summary : Lactocele, also known as galactocele, is related to jak3-deficient severe combined immunodeficiency and hyperprolactinemia. An important gene associated with Lactocele is MT-ND2 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Affiliated tissues include brain, thyroid and t cells, and related phenotypes are Decreased viability in HMC1.1 cells and immune system

Wikipedia : 76 A galactocele (also: lacteal cyst or milk cyst) is a retention cyst containing milk or a milky substance... more...

Related Diseases for Lactocele

Graphical network of the top 20 diseases related to Lactocele:



Diseases related to Lactocele

Symptoms & Phenotypes for Lactocele

GenomeRNAi Phenotypes related to Lactocele according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in HMC1.1 cells GR00105-A-0 8.62 JAK1 JAK3

MGI Mouse Phenotypes related to Lactocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD68 JAK1 JAK2 JAK3 LHCGR MT-ND2

Drugs & Therapeutics for Lactocele

Search Clinical Trials , NIH Clinical Center for Lactocele

Cochrane evidence based reviews: galactocele

Genetic Tests for Lactocele

Anatomical Context for Lactocele

MalaCards organs/tissues related to Lactocele:

41
Brain, Thyroid, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Lactocele:

19
The Mammary Gl

Publications for Lactocele

Articles related to Lactocele:

(show all 46)
# Title Authors Year
1
Cytological diagnosis of crystallizing galactocele - report of an unusual case. ( 29286912 )
2018
2
Galactocele, Pitfall for the Evaluation by 18F-FDG PET/CT. ( 29847317 )
2018
3
Crystallizing Galactocele: A rare entity-report of two cases. ( 30144343 )
2018
4
Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation. ( 30456639 )
2018
5
Galactocele of adult male breast: A cytopathologist's perspective. ( 30461216 )
2018
6
Galactocele in a Prepubertal Girl. ( 28126385 )
2017
7
Galactocele in the Axillary Accessory Breast Mimicking Suspicious Solid Mass on Ultrasound. ( 28487794 )
2017
8
Chronic Galactocele. ( 27124312 )
2016
9
Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy. ( 27257574 )
2016
10
Erratum: Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy: Erratum. ( 27579220 )
2016
11
Crystallizing galactocele: Report of a rare variation. ( 27662275 )
2016
12
Galactocele in a Male Infant with Transient Hyperprolactinaemia: An Extremely Rare Cause of Breast Enlargement in Children. ( 27752383 )
2016
13
Unilateral galactocele in a male infant. ( 25831914 )
2015
14
Primary hydatid disease of the breast clinically masquerading as a galactocele: A case report. ( 27847893 )
2015
15
Postaugmentation galactocele. ( 23629139 )
2013
16
Crystallizing galactocele - an unusual diagnosis on fine needle aspiration cytology. ( 23634434 )
2013
17
Peri-implant galactocele following vacuum-assisted core biopsy of the breast: a cautionary tale. ( 23749817 )
2013
18
Galactocele in male infants: report of two cases and review of the literature. ( 22570125 )
2012
19
The galactocele of male infants: an intriguing entity. Study and reflection about a case, with review of the literature. ( 20718614 )
2011
20
Late hematoma, seroma, and galactocele in breasts injected with polyacrylamide gel. ( 21072516 )
2011
21
Postaugmentation galactocele: a case report and review of literature. ( 21346529 )
2011
22
Xanthogranulomatous reaction to a ruptured galactocele. ( 20202042 )
2010
23
Discrepant cytologic and radiographic findings in adjacent galactocele and fibroadenoma: a case report. ( 19365978 )
2009
24
Galactocele: an unusual cause of breast enlargement in children. ( 19573643 )
2009
25
A late complication of augmentation mammoplasty by polyacrylamide hydrogel injection: ultrasound and magnetic resonance imaging findings of huge galactocele formation in a puerperal woman with pathological correlation. ( 19054003 )
2008
26
Galactocele as a changing axillary lump in a pregnant woman. ( 17406878 )
2007
27
Infected galactocele: a perplexing problem. ( 15009047 )
2004
28
Galactocele of the breast in a postmenopausal woman. ( 15165774 )
2004
29
A controlled trial of a new treatment for galactocele. ( 12757066 )
2003
30
Galactocele in a young male patient. ( 12832892 )
2003
31
About images with breast implants and galactocele. ( 14663251 )
2003
32
Unilateral galactocele in a male infant. ( 11786855 )
2002
33
Galactocele: a rare cause of breast enlargement in an infant. ( 11547156 )
2001
34
Crystallizing galactocele. A case report. ( 9167716 )
1997
35
Unilateral galactocele following augmentation mammoplasty. ( 7944201 )
1994
36
Galactocele in a male infant: case report and review of literature. ( 8516225 )
1993
37
Breastfeeding difficulties and a breast abscess associated with a galactocele: a case report. ( 8260035 )
1993
38
Radiological case of the month. Galactocele. ( 1286987 )
1992
39
Galactocele of the breast: radiologic and ultrasonographic findings. ( 2178721 )
1990
40
Galactocele: three distinctive radiographic appearances. ( 3737931 )
1986
41
Galactocele: three distinctive radiographic appearances. ( 3940395 )
1986
42
Galactocele of the breast. ( 5011932 )
1972
43
Bilateral galactocele in a male infant. ( 6029470 )
1967
44
GALACTOCELE OF THE BREAST. ( 14215116 )
1964
45
Galactocele in male infant. ( 13037429 )
1953
46
A Case of Scrotal Galactocele. ( 18734634 )
1909

Variations for Lactocele

Expression for Lactocele

Search GEO for disease gene expression data for Lactocele.

Pathways for Lactocele

Pathways related to Lactocele according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 JAK1 JAK2 JAK3 PRL TRIM21
2
Show member pathways
12.75 JAK1 JAK2 JAK3 PRL
3 12.36 JAK1 JAK2 JAK3
4
Show member pathways
12.33 JAK1 JAK2 TRIM21
5
Show member pathways
12.17 JAK1 JAK2 JAK3
6
Show member pathways
12.16 JAK1 JAK2 JAK3
7
Show member pathways
12.1 JAK1 JAK2 JAK3
8
Show member pathways
12.09 JAK1 JAK2 JAK3
9
Show member pathways
12.02 JAK1 JAK2 JAK3
10
Show member pathways
12.01 JAK1 JAK2 LHCGR PRL
11
Show member pathways
11.99 JAK1 JAK2 JAK3 PRL
12
Show member pathways
11.96 JAK1 JAK2 JAK3
13
Show member pathways
11.88 JAK1 JAK2 JAK3
14 11.83 JAK1 JAK2 JAK3
15
Show member pathways
11.8 JAK1 JAK2 JAK3
16
Show member pathways
11.77 JAK1 JAK2 JAK3
17
Show member pathways
11.66 JAK1 JAK2 JAK3
18 11.64 JAK1 JAK2 JAK3
19 11.55 JAK1 JAK2 JAK3
20
Show member pathways
11.51 JAK1 JAK2 JAK3
21
Show member pathways
11.43 JAK1 JAK2
22 11.36 JAK2 PRL
23 11.33 JAK1 JAK2
24
Show member pathways
11.31 JAK1 JAK3
25 11.29 JAK1 JAK2
26
Show member pathways
11.27 JAK1 JAK2
27
Show member pathways
11.26 JAK1 JAK3
28
Show member pathways
11.24 JAK2 PRL
29
Show member pathways
11.21 JAK1 JAK2
30 11.19 JAK1 JAK2 JAK3
31 11.16 JAK1 JAK2
32 11.13 JAK1 JAK2 JAK3
33 11 JAK1 JAK3
34 10.82 JAK1 JAK2
35 10.79 JAK1 JAK2 JAK3
36 10.4 JAK1 JAK2 JAK3

GO Terms for Lactocele

Cellular components related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.46 CD68 JAK1 JAK3 LHCGR
2 endosome lumen GO:0031904 8.96 JAK2 PRL
3 endomembrane system GO:0012505 8.8 JAK1 JAK2 JAK3

Biological processes related to Lactocele according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.77 JAK1 JAK2 JAK3
2 MAPK cascade GO:0000165 9.74 JAK1 JAK2 JAK3
3 peptidyl-tyrosine phosphorylation GO:0018108 9.71 JAK1 JAK2 JAK3
4 hormone-mediated signaling pathway GO:0009755 9.6 JAK2 LHCGR
5 erythrocyte differentiation GO:0030218 9.58 JAK2 JAK3
6 interleukin-12-mediated signaling pathway GO:0035722 9.58 JAK1 JAK2
7 response to antibiotic GO:0046677 9.56 JAK1 JAK2
8 interleukin-7-mediated signaling pathway GO:0038111 9.55 JAK1 JAK3
9 interleukin-6-mediated signaling pathway GO:0070102 9.52 JAK1 JAK2
10 interleukin-15-mediated signaling pathway GO:0035723 9.51 JAK1 JAK3
11 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 JAK1 JAK2
12 interleukin-27-mediated signaling pathway GO:0070106 9.48 JAK1 JAK2
13 interleukin-2-mediated signaling pathway GO:0038110 9.46 JAK1 JAK3
14 interleukin-35-mediated signaling pathway GO:0070757 9.43 JAK1 JAK2
15 regulation of JAK-STAT cascade GO:0046425 9.4 JAK2 JAK3
16 interleukin-9-mediated signaling pathway GO:0038113 9.37 JAK1 JAK3
17 tyrosine phosphorylation of STAT protein GO:0007260 9.32 JAK2 JAK3
18 enzyme linked receptor protein signaling pathway GO:0007167 9.26 JAK2 JAK3
19 interleukin-21-mediated signaling pathway GO:0038114 9.16 JAK1 JAK3
20 interferon-gamma-mediated signaling pathway GO:0060333 9.13 JAK1 JAK2 TRIM21
21 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 JAK2 JAK3 PRL

Molecular functions related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 JAK1 JAK2 JAK3
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 JAK1 JAK2 JAK3
3 growth hormone receptor binding GO:0005131 8.96 JAK1 JAK2
4 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.8 JAK1 JAK2 JAK3

Sources for Lactocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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