MCID: LCT003
MIFTS: 34

Lactocele

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Lactocele

MalaCards integrated aliases for Lactocele:

Name: Lactocele 12 53 15
Galactocele 12 53 44
Galactocoele 53
Lacteal Cyst 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10686
ICD9CM 35 611.5
MeSH 44 C535998
NCIt 50 C3515
SNOMED-CT 68 42385006
ICD10 33 N64.89
UMLS 72 C0152243

Summaries for Lactocele

Disease Ontology : 12 A breast cyst that develops during or shortly after lactation and is characterized by retention of milk or a milky substance that is usually located in the mammary glands.

MalaCards based summary : Lactocele, also known as galactocele, is related to galactorrhea and hyperprolactinemia. An important gene associated with Lactocele is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Affiliated tissues include mammary glands and breast, and related phenotypes are Decreased viability in HMC1.1 cells and immune system

Wikipedia : 75 A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky... more...

Related Diseases for Lactocele

Diseases related to Lactocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 10.3
2 hyperprolactinemia 10.3
3 pituitary adenoma, prolactin-secreting 10.2
4 breast abscess 10.2
5 infant gynecomastia 10.2
6 gynecomastia 10.2
7 breast fibroadenoma 10.2
8 breast disease 10.2
9 adenoma 10.2
10 jak3-deficient severe combined immunodeficiency 10.1 JAK3 JAK1
11 t-cell prolymphocytic leukemia 10.1 JAK3 JAK1
12 lipomatosis, multiple 10.0
13 down syndrome 10.0
14 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
15 congenital hypothyroidism 10.0
16 diffuse large b-cell lymphoma 10.0
17 desmoid tumor 10.0
18 hypogonadotropic hypogonadism 10.0
19 pleomorphic lipoma 10.0
20 breast cyst 10.0
21 mastitis 10.0
22 hypothyroidism 10.0
23 benign breast phyllodes tumor 10.0
24 hypogonadism 10.0
25 granular cell tumor 10.0
26 hemangioma 10.0
27 papilloma 10.0
28 mammary paget's disease 10.0
29 b-cell lymphoma 10.0
30 hypogonadotropism 10.0
31 pregnancy adenoma 10.0
32 chronic kidney disease 10.0
33 hypopituitarism 10.0
34 fibromatosis 10.0
35 pituitary tumors 10.0
36 non-acquired combined pituitary hormone deficiency 10.0
37 chilblain lupus 1 9.9 TRIM21 JAK1
38 amenorrhea 9.8 PRL LHCGR
39 primary polycythemia 9.7 JAK2 JAK1
40 lymphoblastic leukemia, acute, with lymphomatous features 9.4 JAK3 JAK2 JAK1
41 polycythemia vera 9.4 JAK3 JAK2 JAK1
42 myeloproliferative neoplasm 9.3 JAK3 JAK2

Graphical network of the top 20 diseases related to Lactocele:



Diseases related to Lactocele

Symptoms & Phenotypes for Lactocele

GenomeRNAi Phenotypes related to Lactocele according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in HMC1.1 cells GR00105-A-0 8.62 JAK1 JAK3

MGI Mouse Phenotypes related to Lactocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD68 JAK1 JAK2 JAK3 LHCGR MT-ND2

Drugs & Therapeutics for Lactocele

Search Clinical Trials , NIH Clinical Center for Lactocele

Cochrane evidence based reviews: galactocele

Genetic Tests for Lactocele

Anatomical Context for Lactocele

The Foundational Model of Anatomy Ontology organs/tissues related to Lactocele:

19
Mammary Glands

MalaCards organs/tissues related to Lactocele:

41
Breast

Publications for Lactocele

Articles related to Lactocele:

(show top 50) (show all 94)
# Title Authors PMID Year
1
Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation. 38
30456639 2019
2
Breastfeeding pathologies: analysis of prevalence, risk and protective factors. 38
30977749 2019
3
Galactocele of adult male breast: A cytopathologist's perspective. 38
30461216 2019
4
Crystallizing Galactocele: A rare entity-report of two cases. 38
30144343 2018
5
Galactocele, Pitfall for the Evaluation by 18F-FDG PET/CT. 38
29847317 2018
6
Hyperechoic breast images: all that glitters is not gold! 38
29476429 2018
7
Cytological diagnosis of crystallizing galactocele - report of an unusual case. 38
29286912 2018
8
Galactocele in a Prepubertal Girl. 38
28126385 2017
9
Galactocele in the Axillary Accessory Breast Mimicking Suspicious Solid Mass on Ultrasound. 38
28487794 2017
10
[A rare case of giant galactocele associated with prolactinoma]. 38
28819518 2017
11
Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells. 38
27708194 2017
12
Chronic Galactocele. 38
27124312 2016
13
Crystallizing galactocele: Report of a rare variation. 38
27662275 2016
14
Erratum: Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy: Erratum. 38
27579220 2016
15
Postaugmentation Galactocele Without Periareolar Incision and 8 Years After Pregnancy. 38
27257574 2016
16
Galactocele in a Male Infant with Transient Hyperprolactinaemia: An Extremely Rare Cause of Breast Enlargement in Children. 38
27752383 2016
17
[Rare benign breast tumors including Abrikossoff tumor (granular cell tumor), erosive adenomatosis of the nipple, cytosteatonecrosis, fibromatosis (desmoid tumor), galactocele, hamartoma, hemangioma, lipoma, juvenile papillomatosis, pseudoangiomatous hyperplasia, and syringomatous adenoma: Guidelines for clinical practice]. 38
26530177 2015
18
Breast lumps in pregnant women. 38
26341843 2015
19
Diagnosis and management of galactorrhea after breast augmentation. 38
25919249 2015
20
Primary hydatid disease of the breast clinically masquerading as a galactocele: A case report. 38
27847893 2015
21
[Lactation after breast plastic surgery: literature review]. 38
25147123 2015
22
Unilateral galactocele in a male infant. 38
25831914 2015
23
Digital breast tomosynthesis in the analysis of fat-containing lesions. 38
24617683 2014
24
Bilateral galactocele in a male infant with Down syndrome and congenital hypothyroidism. 38
24134763 2013
25
Peri-implant galactocele following vacuum-assisted core biopsy of the breast: a cautionary tale. 38
23749817 2013
26
Postaugmentation galactocele. 38
23629139 2013
27
Echogenic breast masses at US: to biopsy or not to biopsy? 38
23479705 2013
28
Crystallizing galactocele - an unusual diagnosis on fine needle aspiration cytology. 38
23634434 2013
29
Clinicopathologic profile of benign breast conditions in Indian women: prospective study based on aberrations of normal development and involution classification. 38
22744217 2012
30
Polyacrylamide hydrogel injection for augmentation mammaplasty: loss of ability for breastfeeding. 38
21785335 2012
31
Late seroma during pregnancy, a rare complication in prosthetic breast augmentation: case report. 38
22119792 2012
32
Galactocele in male infants: report of two cases and review of the literature. 38
22570125 2012
33
Postaugmentation galactocele: a case report and review of literature. 38
21346529 2011
34
Late hematoma, seroma, and galactocele in breasts injected with polyacrylamide gel. 38
21072516 2011
35
The galactocele of male infants: an intriguing entity. Study and reflection about a case, with review of the literature. 38
20718614 2011
36
Large unilateral breast autoinflation after breastfeeding linked to polyacrylamide hydrogel injection augmentation mammaplasty. 38
20652566 2011
37
Xanthogranulomatous reaction to a ruptured galactocele. 38
20202042 2010
38
Fine needle aspiration of breast masses in HIV-infected patients: results from a large series. 38
20572291 2010
39
Galactocele: an unusual cause of breast enlargement in children. 38
19573643 2009
40
Discrepant cytologic and radiographic findings in adjacent galactocele and fibroadenoma: a case report. 38
19365978 2009
41
Hyperprolactinemia and galactocele formation after augmentation mammoplasty. 38
19158518 2009
42
Galactocele and prolactinoma--a pathogenic association? 38
19110385 2009
43
Persistent hyperprolactinemia and bilateral galactocele in a male infant. 38
19956638 2009
44
[Giant galactocele in a lactating woman]. 38
19084727 2008
45
A late complication of augmentation mammoplasty by polyacrylamide hydrogel injection: ultrasound and magnetic resonance imaging findings of huge galactocele formation in a puerperal woman with pathological correlation. 38
19054003 2008
46
Galactocele as a changing axillary lump in a pregnant woman. 38
17406878 2007
47
Radiologic evaluation of breast disorders related to pregnancy and lactation. 38
18180221 2007
48
The appearances of benign breast diseases on ultrasound. 38
17111730 2006
49
Galactoceles mimicking suspicious solid masses on sonography. 38
16439776 2006
50
An uncommon complication of secondary augmentation mammoplasty: bilaterally massive engorgement of breasts after pregnancy attributable to postinfection and blockage of mammary ducts. 38
15948017 2005

Variations for Lactocele

Expression for Lactocele

Search GEO for disease gene expression data for Lactocele.

Pathways for Lactocele

Pathways related to Lactocele according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 TRIM21 PRL JAK3 JAK2 JAK1
2
Show member pathways
12.73 PRL JAK3 JAK2 JAK1
3
Show member pathways
12.39 JAK3 JAK2 JAK1
4 12.36 JAK3 JAK2 JAK1
5
Show member pathways
12.33 TRIM21 JAK2 JAK1
6
Show member pathways
12.17 JAK3 JAK2 JAK1
7
Show member pathways
12.16 JAK3 JAK2 JAK1
8
Show member pathways
12.09 JAK3 JAK2 JAK1
9
Show member pathways
12.09 JAK3 JAK2 JAK1
10
Show member pathways
12.02 JAK3 JAK2 JAK1
11
Show member pathways
12.01 PRL LHCGR JAK2 JAK1
12
Show member pathways
11.99 PRL JAK3 JAK2 JAK1
13
Show member pathways
11.96 JAK3 JAK2 JAK1
14
Show member pathways
11.88 JAK3 JAK2 JAK1
15 11.83 JAK3 JAK2 JAK1
16
Show member pathways
11.8 JAK3 JAK2 JAK1
17
Show member pathways
11.77 JAK3 JAK2 JAK1
18 11.64 JAK3 JAK2 JAK1
19
Show member pathways
11.63 JAK3 JAK2 JAK1
20 11.58 JAK3 JAK2 JAK1
21 11.51 JAK2 JAK1
22
Show member pathways
11.51 JAK3 JAK2 JAK1
23
Show member pathways
11.5 JAK3 JAK1
24
Show member pathways
11.43 JAK2 JAK1
25 11.36 PRL JAK2
26 11.33 JAK2 JAK1
27
Show member pathways
11.31 JAK3 JAK1
28 11.29 JAK2 JAK1
29
Show member pathways
11.27 JAK3 JAK1
30
Show member pathways
11.26 JAK2 JAK1
31
Show member pathways
11.25 PRL JAK2
32
Show member pathways
11.21 JAK2 JAK1
33 11.18 JAK3 JAK2 JAK1
34 11.18 JAK2 JAK1
35 11.13 JAK3 JAK2 JAK1
36 11.01 JAK3 JAK1
37 10.82 JAK2 JAK1
38 10.79 JAK3 JAK2 JAK1
39 10.4 JAK3 JAK2 JAK1

GO Terms for Lactocele

Cellular components related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.46 LHCGR JAK3 JAK1 CD68
2 endosome lumen GO:0031904 8.96 PRL JAK2
3 endomembrane system GO:0012505 8.8 JAK3 JAK2 JAK1

Biological processes related to Lactocele according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.75 JAK3 JAK2 JAK1
2 MAPK cascade GO:0000165 9.74 JAK3 JAK2 JAK1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.71 JAK3 JAK2 JAK1
4 hormone-mediated signaling pathway GO:0009755 9.6 LHCGR JAK2
5 interleukin-12-mediated signaling pathway GO:0035722 9.59 JAK2 JAK1
6 erythrocyte differentiation GO:0030218 9.58 JAK3 JAK2
7 response to antibiotic GO:0046677 9.56 JAK2 JAK1
8 interleukin-7-mediated signaling pathway GO:0038111 9.55 JAK3 JAK1
9 interleukin-6-mediated signaling pathway GO:0070102 9.52 JAK2 JAK1
10 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.51 JAK2 JAK1
11 interleukin-15-mediated signaling pathway GO:0035723 9.49 JAK3 JAK1
12 regulation of JAK-STAT cascade GO:0046425 9.48 JAK3 JAK2
13 interleukin-35-mediated signaling pathway GO:0070757 9.46 JAK2 JAK1
14 interleukin-2-mediated signaling pathway GO:0038110 9.43 JAK3 JAK1
15 interleukin-27-mediated signaling pathway GO:0070106 9.4 JAK2 JAK1
16 tyrosine phosphorylation of STAT protein GO:0007260 9.37 JAK3 JAK2
17 interleukin-9-mediated signaling pathway GO:0038113 9.32 JAK3 JAK1
18 interleukin-21-mediated signaling pathway GO:0038114 9.26 JAK3 JAK1
19 enzyme linked receptor protein signaling pathway GO:0007167 9.16 JAK3 JAK2
20 interferon-gamma-mediated signaling pathway GO:0060333 9.13 TRIM21 JAK2 JAK1
21 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 PRL JAK3 JAK2

Molecular functions related to Lactocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.33 JAK3 JAK2 JAK1
2 growth hormone receptor binding GO:0005131 8.96 JAK2 JAK1
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.8 JAK3 JAK2 JAK1

Sources for Lactocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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