Lactose Intolerance disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MedlinePlus Genetics: ⁴² Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine.Congenital lactase deficiency, also called congenital alactasia, is a disorder in which infants are unable to break down lactose in breast milk or formula. This form of lactose intolerance results in severe diarrhea. If affected infants are not given a lactose-free infant formula, they may develop severe dehydration and weight loss.Lactose intolerance in adulthood is caused by reduced production of lactase after infancy (lactase nonpersistence). If individuals with lactose intolerance consume lactose-containing dairy products, they may experience abdominal pain, bloating, flatulence, nausea, and diarrhea beginning 30 minutes to 2 hours later.Most people with lactase nonpersistence retain some lactase activity and can include varying amounts of lactose in their diets without experiencing symptoms. Often, affected individuals have difficulty digesting fresh milk but can eat certain dairy products such as cheese or yogurt without discomfort. These foods are made using fermentation processes that break down much of the lactose in milk.

MalaCards based summary: Lactose Intolerance, also known as lactose malabsorption, is related to lactose intolerance, adult type and lactase deficiency, congenital, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Digestion and absorption. The drugs Caseins and Mango have been mentioned in the context of this disorder. Affiliated tissues include breast, kidney and small intestine, and related phenotypes are Reduced mammosphere formation and endocrine/exocrine gland

PubMed Health : ⁶³ Lactose intolerance: Stomach ache, bloating, "gas" and diarrhea are all typical digestive symptoms that some people have after eating or drinking dairy products. People who have difficulty digesting dairy products may only tolerate small amounts of lactose (a sugar found in milk and other dairy products). This is called lactose intolerance. But some people who are sensitive to milk might actually have a different problem. It is important to get the diagnosis right before deciding to make major changes to your diet, especially in children, teenagers and people who need more calcium. Lactose intolerance is not an allergy. This is an important difference. People who have a true milk allergy can react to even a tiny amount of dairy foods or milk. But people who are lactose intolerant can sometimes consume quite a lot of these products without having any major problems.

MedlinePlus: ⁴¹ Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have: Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Disease Ontology: ¹¹ A carbohydrate metabolic disorder that is characterized by the impaired ability to digest lactose.

Wikipedia: ⁷⁵ Lactose intolerance is a common condition caused by a decreased ability to digest lactose, a sugar found... more...

Sources

Related Diseases for Lactose Intolerance

Diseases in the Lactose Intolerance family:

Lactose Intolerance, Adult Type

Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)

#	Related Disease	Score	Top Affiliating Genes
1	lactose intolerance, adult type	32.9	MCM6 LCT
2	lactase deficiency, congenital	32.5	SLC2A5 MCM6 LCT GLB1
3	osmotic diarrhea	31.8	SLC2A5 LCT ATP4A ATP12A
4	diarrhea	31.5	TGM2 SI LCT IL6 IL10 ALB
5	irritable bowel syndrome	30.7	TGM2 LCT IL6 IL10 CRP
6	milk allergy	30.7	LALBA IL10 CSN2 CSN1S1
7	food allergy	30.5	LALBA IL10 CSN1S1
8	immunoglobulin alpha deficiency	30.4	TOR1A TGM2 IL10
9	functional diarrhea	30.4	ATP4A ATP12A
10	kwashiorkor	30.3	INS CRP ALB
11	protein-energy malnutrition	30.3	SI IL6 ALB
12	acute diarrhea	30.3	IL10 CRP ALB
13	blind loop syndrome	30.2	ATP4A ATP12A ALB
14	wheat allergy	30.2	TOR1A TGM2 ALB
15	sucrase-isomaltase deficiency, congenital	30.2	SLC2A5 SI LCT
16	gastroenteritis	30.1	IL6 IL10 CRP ANPEP ALB
17	nutritional deficiency disease	30.1	SI IL6 CRP ATP4A ATP12A ALB
18	marasmus	30.1	INS CRP ALB
19	crohn's colitis	30.1	IL6 IL10 CRP
20	adult syndrome	30.0	INS IL6 CRP
21	graves disease 1	30.0	PTH INS CRP ALB
22	thyroiditis	29.9	INS IL6 IL10 CRP
23	giardiasis	29.9	TOR1A TGM2 LCT IL10 ATP4A ATP12A
24	enterocolitis	29.8	IL6 IL10 CRP
25	duodenal ulcer	29.8	INS IL6 IL10
26	iron deficiency anemia	29.8	IL6 CRP ATP4A
27	brucellosis	29.8	IL6 IL10 CRP
28	crohn's disease	29.8	IL6 IL10 CRP ALB
29	familial mediterranean fever	29.7	IL6 IL10 CRP
30	non-alcoholic steatohepatitis	29.7	INS IL6 ALB
31	allergic disease	29.7	LALBA IL6 IL10 CSN1S1
32	dental caries	29.7	IL6 CSN1S1 CRP ALB
33	mental depression	29.6	INS IL6 IL10 CRP
34	glucose intolerance	29.6	INS IL6 CRP ALB
35	otitis media	29.5	IL6 IL10 CRP ALB
36	arteries, anomalies of	29.5	INS IL6 CRP ALB
37	autoimmune disease	29.5	TGM2 INS IL6 IL10 CRP ANPEP
38	fatty liver disease	29.5	INS IL6 IL10 CRP
39	osteoporosis	29.4	TGM2 PTH LCT INS IL6 IL10
40	dysentery	29.3	SI IL6 IL10 CRP ATP4A ATP12A
41	exanthem	29.3	IL6 IL10 CRP ATP12A ALB
42	anxiety	29.3	INS IL6 IL10 CRP ALB
43	bilirubin metabolic disorder	29.3	INS IL6 IL10 CRP ATP4A ATP12A
44	atherosclerosis susceptibility	29.2	INS IL6 IL10 CRP ALB
45	rectal disease	29.2	IL6 IL10 CRP ATP4A ATP12A ALB
46	perinatal necrotizing enterocolitis	29.1	LALBA IL6 IL10 CSN1S1 CRP ALB
47	peptic ulcer disease	29.0	INS IL6 IL10 CRP ATP4A ATP12A
48	lipoprotein quantitative trait locus	29.0	PTH INS IL6 IL10 CRP ALB
49	cystic fibrosis	29.0	TGM2 INS IL6 IL10 CRP ATP12A
50	bowel dysfunction	28.9	SI PTH LCT INS IL6 IL10

Graphical network of the top 20 diseases related to Lactose Intolerance:

Sources

Symptoms & Phenotypes for Lactose Intolerance

UMLS symptoms related to Lactose Intolerance:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

GenomeRNAi Phenotypes related to Lactose Intolerance according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.19	ALB ANPEP ATP12A ATP4A CRP CSN1S1
2	no effect	GR00402-S-2	10.19	ALB ANPEP ATP12A ATP4A CRP CSN1S1
3	Reduced mammosphere formation	GR00396-S	9.5	ALB ATP4A GLB1 LALBA MCM6 RECK

MGI Mouse Phenotypes related to Lactose Intolerance:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.4	ALB ANPEP ATP4A CSN1S1 CSN2 IL10

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Drugs & Therapeutics for Lactose Intolerance

Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Caseins

Phase 4

2

Mango

Approved

3

Turmeric

Approved, Experimental, Investigational

4

Orange

Approved

5

Sorbitol

Approved, Investigational

69-65-8, 50-70-4

453 6251 5780

6

Alverine

Approved, Investigational

150-59-4

3678

7

Sodium citrate

Approved, Investigational

68-04-2

23431961

8

Simethicone

Approved

8050-81-5

9

Mebeverine

Approved, Investigational

3625-06-7

4031

10

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8

5280382 445354

11

Citric acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

12

Acidophilus

13

Retinol palmitate

14

Turmeric extract

15

Pharmaceutical Solutions

16

Insulin, Globin Zinc

17

Insulin

18

Soy Bean

19

Anti-Infective Agents

20

Antiprotozoal Agents

21

Antiparasitic Agents

22

Antimalarials

23

Sulfalene

24

Cola

25

Parasympatholytics

26

Calcium, Dietary

27

Anticonvulsants

28

Anticoagulants

29

Emollients

30

Dermatologic Agents

31

Citrate

32

Chelating Agents

33

Calcium

Nutraceutical

7440-70-2

271

Interventional clinical trials:

(show all 40)

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Impact of LacTEST on Diagnostic Thinking and on Patient Management, and of the Reproducibility (Test-Retest), for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance	Completed	NCT02636413	Phase 4	gaxilose
2	Comparative Effects of Milk With A2 Type Beta Casein Versus Milk With A1 and A2 Beta Casein Proteins on Gastrointestinal Physiology, Symptoms and Cognitive Behavior for the Health People Who Are Intolerant to Traditional Cow Milk	Completed	NCT02406469	Phase 4
3	Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People	Completed	NCT02878876	Phase 4
4	A Phase 2b/3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Two Doses of RP-G28 in Subjects With Lactose Intolerance	Completed	NCT02673749	Phase 2, Phase 3	RP-G28
5	A Phase III, Non-Inferiority, Randomized, Blind, Parallel-Group, Multicentre, Multiple-Dose, Comparative Clinical Study of Lactase Eurofarma and Lactaid®, Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance"	Completed	NCT01145586	Phase 3	Lactase Oral Tablets
6	A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance	Completed	NCT03597516	Phase 3	RP-G28;Placebos
7	A Phase III, Non-Inferiority, Randomized, Double-Blind, Parallel-Group, Multicentre, Single-Dose, Comparative Clinical Study of Lactase Eurofarma (Test Drug) and Lactaid® (Comparative Drug), Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance (Hypolactasia)	Completed	NCT01145339	Phase 3	Lactase
8	Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS.	Recruiting	NCT05120752	Phase 3
9	Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Effectiveness, Safety and Tolerability of RP-G28 in Subjects With Symptoms Associated With Lactose Intolerance	Completed	NCT01113619	Phase 2	RP-G28 or placebo
10	Prospective, Open-Label, Randomized, Two-Period, Two-Sequence, Crossover Study Comparing RP-G28 Administered in the Fasted State and the Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Volunteers	Completed	NCT03563846	Phase 1	RP-G28
11	Effect of the Consumption of a Probiotic (B. Bifidum 900791)-Containing Ice-cream in Adult With Hypolactasia and Lactose Intolerance	Unknown status	NCT03952988
12	The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population	Unknown status	NCT01286597
13	Does Daily Supplementation of Lactobacillus Acidophilus MPH734 (Lacto-FreedomTM, or LF), for One Week, Affects Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation (30-, 60-, and 90- Day) Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo?	Unknown status	NCT04531033
14	Effect of Whole Milk Intake on the Cardio-metabolic Risk Factors of Healthy Person With or Without Lactose Maldigestion	Unknown status	NCT02798718
15	Nutritional Clinical Trial to Evaluate the Regular Consumption Effect of a Probiotic With High Beta-galactosidase Activity Over Lactose Intolerance Gastrointestinal Symptoms in Patients With Lactose Intolerance	Completed	NCT05367453
16	Efficacy of Probiotic I31 on Symptomatic Improvement in Patients With Lactose Intolerance	Completed	NCT04164394
17	Evaluation of GIMate Handheld Hydrogen Breath Monitor for Diagnosis of Lactose Malabsorption	Completed	NCT04754724
18	A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People.	Completed	NCT00395954
19	A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People Who Also Have Ulcerative Colitis	Completed	NCT00403923
20	Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution: Randomized, Double-blind, Placebo-controlled, Positive-controlled, Three-way Crossover, Acute Lactose Challenge	Completed	NCT03814668
21	A Randomized, Controlled, Double-blind, Cross-over, Single-centre Study to Investigate the Effect of a Fermented Infant Formula on Lactose Digestion in Lactose Intolerant Adults	Completed	NCT02703987
22	The Effect of Probiotics on Lactose Intolerance	Completed	NCT01593800
23	Clinical Utility of Carbohydrate Breath Tests in Unexplained GI Symptoms	Completed	NCT03261856
24	Differential Biologic Impact of Lactose Consumption in Lactase Persistent and Non-persistent Populations: Evaluation of Microflora and Insulin/Glycemic Response	Completed	NCT00599859
25	Comparison of Raw Milk Consumption vs. Other Milk Sources on Lactose Digestion in Healthy Individuals With Self-reported Lactose Intolerance	Completed	NCT01129791
26	β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion: Probiotic and Lactose Intolerance	Completed	NCT02518295
27	Modulation of Lactase Expression by a New Synthetic PPARgamma Ligand in Ex-vivo Cultures of Duodenal Biopsies	Completed	NCT02902016		GED
28	Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls	Completed	NCT02171403
29	Understanding Perceived Lactose Intolerance in White, Black, and Hispanic Adults	Completed	NCT01331265
30	Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients	Completed	NCT03008252
31	Secondary Lactose Intolerance Due to Chronic Norovirus Infection in Renal Transplant Recipients	Completed	NCT01840891
32	Effects of A2 Milk on Gastrointestinal Function of Volunteers Affected by Non-lactose Milk Intolerance	Completed	NCT03060395
33	A Combination of Yoghurt Bacteria and Acid Lactase From Aspergillus Oryzae Improves Lactose Digestion in Lactose Malabsorbers More Reliably Than Preparations Containing Acid Lactase or Yoghurt Bacteria Alone	Completed	NCT01593631
34	Comparison of Two Extensively Hydrolyzed Formulas for the Treatment of Children With Cow's Milk Intolerance	Completed	NCT01727115
35	Association Between Lactase Deficiency, Symptoms of Lactose Intolerance, and the Small Intestinal Microbiome in Adults	Recruiting	NCT03860051
36	Fructose and Lactose Intolerance and Malabsorption: the Relationship Between Metabolism and Symptoms in Functional Gastrointestinal Disorders	Recruiting	NCT02085889
37	Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyses A1 Milk	Recruiting	NCT05305391
38	The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION Trial): Protocol of a Multicentre Randomized Controlled Clinical Trial	Not yet recruiting	NCT05100719		alverine-citrate + simethicone and lactase;alverin-citrate + simethicone with placebo
39	Prevalence of Lactose Intolerance Following Stem Cell Transplantation in Pediatric Patients.	Terminated	NCT00247806
40	A Study to Validate a Home-screening Test for Lactose Intolerant People	Withdrawn	NCT00844766

Search NIH Clinical Center for Lactose Intolerance

Cochrane evidence based reviews: lactose intolerance

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Genetic Tests for Lactose Intolerance

Sources

Anatomical Context for Lactose Intolerance

Organs/tissues related to Lactose Intolerance:

MalaCards : Breast, Kidney, Small Intestine, Bone, Colon, Heart, Amygdala

Sources

Publications for Lactose Intolerance

Articles related to Lactose Intolerance:

(show top 50) (show all 2338)

#	Title	Authors	PMID	Year
1	The Perception of Lactose-Related Symptoms of Patients with Lactose Malabsorption. ⁶² ⁴¹	Di Stefano M...Di Sabatino A	36011869	2022
2	Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose. ⁶² ⁴¹	Marabotto E...Giannini EG	35893871	2022
3	Serum and Urine Metabolites in Healthy Men after Consumption of Acidified Milk and Yogurt. ⁴¹	Butikofer U...Vergeres G	36432479	2022
4	Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population. ⁵³ ⁶²	Bacsi K...Speer G	18980667	2008
5	Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. ⁵³ ⁶²	Weiskirchen R...Swallow DM	17651714	2007
6	Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? ⁵³ ⁶²	Kerber M...Ledochowski M	17574225	2007
7	Hypolactasia as a molecular basis of lactose intolerance. ⁵³ ⁶²	Kaur K...Mahmood A	17133732	2006
8	Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase. ⁵³ ⁶²	He W...Huang CY	17190185	2006
9	T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. ⁵³ ⁶²	Lewinsky RH...Troelsen JT	16301215	2005
10	The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. ⁵³ ⁶²	Buning C...Schmidt H	12795467	2003
11	Identification of a variant associated with adult-type hypolactasia. ⁵³ ⁶²	Enattah NS...Jarvela I	11788828	2002
12	Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. ⁵³ ⁶²	Naim HY	11332711	2001
13	[Idiopathic thrombocytopenic purpura and food allergy: a study on possible correlations]. ⁵³ ⁶²	Massolo F...Venuta A	10335541	1998
14	Antibodies to lactoferrin--a possible link between cow's milk intolerance and autoimmune disease. ⁵³ ⁶²	Brock JH...Lonnerdal B	9191361	1997
15	Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes. ⁵³ ⁶²	Sterchi EE...Bond J	1976654	1990
16	Streptomyces genus as a source of probiotics and its potential for its use in health. ⁶²	Cuozzo S...Tortella GR	36335804	2023
17	Revealing Joseon period People's single nucleotide polymorphism associated with lactase gene by ancient DNA analysis of human remains from archaeological sites in Korea. ⁶²	Oh CS...Shin DH	36450657	2022
18	Small Intestinal Bacterial Overgrowth in Patients with Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass. ⁶²	Novljan U...Pintar T	36197573	2022
19	The use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals. ⁶²	Oliveira LS...Casaril KBPB	36308983	2022
20	Relationships of Intestinal Lactase and the Small Intestinal Microbiome with Symptoms of Lactose Intolerance and Intake in Adults. ⁶²	Jansson-Knodell CL...Shin A	35322314	2022
21	White as milk: Biocentric bias in the framing of lactose intolerance and lactase persistence. ⁶²	Kaufman EJ...Tan C	36018892	2022
22	Cow's milk-induced gastrointestinal disorders: From infancy to adulthood. ⁶²	Al-Beltagi M...Elbeltagi R	36439902	2022
23	Lactose Content and Selected Quality Parameters of Sheep Milk Fermented Beverages during Storage. ⁶²	Czyzak-Runowska G...Stanislawski D	36428333	2022
24	Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population. ⁶²	Nemeth S...Sarkisian T	36129808	2022
25	Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women. ⁶²	Chen Q...Chen W	36364729	2022
26	Effects of Probiotic Fermented Fruit Juice-Based Biotransformation by Lactic Acid Bacteria and Saccharomyces boulardii CNCM I-745 on Anti-Salmonella and Antioxidative Properties. ⁶²	Laosee W...Sirinupong N	36198663	2022
27	Chronic diarrhea - The poetic masquerade. ⁶²	Bhattacharjee S...Maramattom BV	36348608	2022
28	Benefits of Flavored Lactose-Free Milk for Korean Adults with Lactose Intolerance. ⁶²	Oh CH...Park JK	36179067	2022
29	Bacterial overgrowth and lactose intolerance: how to best assess. ⁶²	Ghafoor A...Rao SSC	35838278	2022
30	Bifidobacterium Animalis Subsp. Lactis Bi-07 Supports Lactose Digestion in Vitro and in Randomized, Placebo and Lactase -controlled Clinical Trials. ⁶²	Rasinkangas P...Ouwehand AC	36149331	2022
31	Development of probiotics beverage using cereal enzymatic hydrolysate fermented with Limosilactobacillus reuteri. ⁶²	Yang Z...Qin L	36171765	2022
32	The stressing life of Lactobacillus delbrueckii subsp. bulgaricus in soy milk. ⁶²	Jan G...Gagnaire V	35690436	2022
33	Probiotication of Nutritious Fruit and Vegetable Juices: An Alternative to Dairy-Based Probiotic Functional Products. ⁶²	Mojikon FD...Jawan R	36079714	2022
34	Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities. ⁶²	Peters M...Laisk T	35713579	2022
35	Terahertz Spectroscopic Analysis of Lactose in Infant Formula: Implications for Detection and Quantification. ⁶²	Datta S...Limpanuparb T	35956992	2022
36	Switching from the tablet to the powder formulation of levothyroxine corrects severe hypothyroidism in a patient with lactose intolerance. ⁶²	Jojima T...Aso Y	35249899	2022
37	Efficacy and Safety of a Novel Therapeutic of Natural Origin (NTN) in Adult Patients with Lactose Intolerance: A Multicenter, Randomized, Crossover, Double-Blind, Placebo-Controlled Study. ⁶²	Pop C...Tiuca N	36076786	2022
38	Sixty seconds on . . . lactose intolerance. ⁶²	Looi MK	35905988	2022
39	Effects of different combinations of probiotics on rheology, microstructure, and moisture distribution of soy materials-based yogurt. ⁶²	Xu X...Zhu D	35638330	2022
40	Functional Fermented Probiotics, Prebiotics, and Synbiotics from Non-Dairy Products: A Perspective from Nutraceutical. ⁶²	Kumar D...Singh B	35616160	2022
41	Ultrasonic analysis of effects of varying temperature, pH, and proteolytic enzymes on hydrolysis of lactose by neutral lactase formulations in infant milk and in the infant digestive system. ⁶²	Lynch R...Buckin V	35761512	2022
42	Cloning, Expression, Purification, and Characterization of β-Galactosidase from Bifidobacterium longum and Bifidobacterium pseudocatenulatum. ⁶²	Du M...Xie X	35889370	2022
43	Validation of a modified cow's milk-related symptom score (CoMISS) for screening of lactose intolerance in adults. ⁶²	Mohammed HI...Al-Ashram MNB	35318881	2022
44	Awareness of Lactose Intolerance Disorder in Saudi Arabia Population. ⁶²	Alzahrani MA...Alshahrani AS	36119262	2022
45	Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults. ⁶²	Smith CJ...Relman DA	35695459	2022
46	Lactose: Characteristics, Food and Drug-Related Applications, and Its Possible Substitutions in Meeting the Needs of People with Lactose Intolerance. ⁶²	Dominici S...Facioni MS	35627056	2022
47	International Cross-Sectional Survey among Healthcare Professionals on the Management of Cow's Milk Protein Allergy and Lactose Intolerance in Infants and Children. ⁶²	Madrazo JA...Rogacion JM	35611371	2022
48	Lactose Intolerance and Its Dietary Management: An Update. ⁶²	Katoch GK...Rasane P	33831336	2022
49	Gastrointestinal Conditions: Malabsorption Syndromes. ⁶²	Davis J...Kellerman R	35507311	2022
50	The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? ⁶²	Asfari MM...Sridhar S	35676992	2022

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Genes for Lactose Intolerance

Genes related to Lactose Intolerance (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	LCT	Lactase	Protein Coding	40.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	1976654 12795467 17133732 (more) 16301215 11788828 18980667 17651714 11332711 17574225 17190185
2	MCM6	Minichromosome Maintenance Complex Component 6	Protein Coding	25.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
3	SI	Sucrase-Isomaltase	Protein Coding	12.3	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	11.44	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17133732
5	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	11.3	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	CSN1S1	Casein Alpha S1	Protein Coding	9.53	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10335541
7	CSN2	Casein Beta	Protein Coding	6.64	DISEASES inferred ¹⁴
8	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	6.22	DISEASES inferred ¹⁴
9	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	6.21	DISEASES inferred ¹⁴
10	TGM2	Transglutaminase 2	Protein Coding	6.2	DISEASES inferred ¹⁴
11	TOR1A	Torsin Family 1 Member A	Protein Coding	6.07	DISEASES inferred ¹⁴
12	LALBA	Lactalbumin Alpha	Protein Coding	6.06	DISEASES inferred ¹⁴
13	INS	Insulin	Protein Coding	5.9	DISEASES inferred ¹⁴
14	ALB	Albumin	Protein Coding	5.65	DISEASES inferred ¹⁴
15	IL10	Interleukin 10	Protein Coding	5.64	DISEASES inferred ¹⁴
16	CRP	C-Reactive Protein	Protein Coding	5.6	DISEASES inferred ¹⁴
17	PTH	Parathyroid Hormone	Protein Coding	5.56	DISEASES inferred ¹⁴
18	GLB1	Galactosidase Beta 1	Protein Coding	5.52	DISEASES inferred ¹⁴
19	SLC2A5	Solute Carrier Family 2 Member 5	Protein Coding	5.5	DISEASES inferred ¹⁴
20	IL6	Interleukin 6	Protein Coding	5.49	DISEASES inferred ¹⁴
21	TNF	Tumor Necrosis Factor	Protein Coding	5.46	DISEASES inferred ¹⁴
22	SLC5A1	Solute Carrier Family 5 Member 1	Protein Coding	5.13	DISEASES inferred ¹⁴

Sources

Variations for Lactose Intolerance

ClinVar genetic disease variations for Lactose Intolerance:

⁵ (show top 50) (show all 61)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	LCT	NM_002299.4(LCT):c.54G>C (p.Trp18Cys)	SNV	Uncertain Significance	331214	rs886054870	GRCh37: 2:136594686-136594686 GRCh38: 2:135837116-135837116
2	LCT	NM_002299.4(LCT):c.4434T>C (p.Asp1478=)	SNV	Uncertain Significance	331174	rs778761405	GRCh37: 2:136562367-136562367 GRCh38: 2:135804797-135804797
3	LCT	NM_002299.4(LCT):c.*251G>A	SNV	Uncertain Significance	331157	rs886054860	GRCh37: 2:136545643-136545643 GRCh38: 2:135788073-135788073
4	LCT	NM_002299.4(LCT):c.2177G>A (p.Arg726His)	SNV	Uncertain Significance	331197	rs886054866	GRCh37: 2:136570057-136570057 GRCh38: 2:135812487-135812487
5	LCT	NM_002299.4(LCT):c.319G>A (p.Glu107Lys)	SNV	Uncertain Significance	331212	rs761296720	GRCh37: 2:136594421-136594421 GRCh38: 2:135836851-135836851
6	LCT	NM_002299.4(LCT):c.4695C>T (p.Tyr1565=)	SNV	Uncertain Significance	331170	rs886054862	GRCh37: 2:136558348-136558348 GRCh38: 2:135800778-135800778
7	LCT	NM_002299.4(LCT):c.*10A>C	SNV	Uncertain Significance	331160	rs200994158	GRCh37: 2:136545884-136545884 GRCh38: 2:135788314-135788314
8	LCT	NM_002299.4(LCT):c.5656G>A (p.Val1886Ile)	SNV	Uncertain Significance	331163	rs376732886	GRCh37: 2:136546022-136546022 GRCh38: 2:135788452-135788452
9	LCT	NM_002299.4(LCT):c.3595G>A (p.Ala1199Thr)	SNV	Uncertain Significance	331185	rs886054863	GRCh37: 2:136566322-136566322 GRCh38: 2:135808752-135808752
10	LCT	NM_002299.4(LCT):c.*230T>C	SNV	Uncertain Significance	331158	rs749324196	GRCh37: 2:136545664-136545664 GRCh38: 2:135788094-135788094
11	LCT	NM_002299.4(LCT):c.*325G>C	SNV	Uncertain Significance	331156	rs62170085	GRCh37: 2:136545569-136545569 GRCh38: 2:135787999-135787999
12	LCT	NM_002299.4(LCT):c.3532C>T (p.Leu1178=)	SNV	Uncertain Significance	331186	rs886054864	GRCh37: 2:136566385-136566385 GRCh38: 2:135808815-135808815
13	LCT	NM_002299.4(LCT):c.1780C>G (p.Gln594Glu)	SNV	Uncertain Significance	331199	rs886054867	GRCh37: 2:136570454-136570454 GRCh38: 2:135812884-135812884
14	LCT	NM_002299.4(LCT):c.3286G>A (p.Ala1096Thr)	SNV	Uncertain Significance	331189	rs146467199	GRCh37: 2:136566631-136566631 GRCh38: 2:135809061-135809061
15	LCT	NM_002299.4(LCT):c.3986C>T (p.Thr1329Met)	SNV	Uncertain Significance	331181	rs555708380	GRCh37: 2:136564885-136564885 GRCh38: 2:135807315-135807315
16	LCT	NM_002299.4(LCT):c.3848C>T (p.Thr1283Met)	SNV	Uncertain Significance	331182	rs147755711	GRCh37: 2:136566069-136566069 GRCh38: 2:135808499-135808499
17	LCT	NM_002299.4(LCT):c.5529C>T (p.Pro1843=)	SNV	Uncertain Significance	331165	rs761696901	GRCh37: 2:136547175-136547175 GRCh38: 2:135789605-135789605
18	LCT	NM_002299.4(LCT):c.3390G>A (p.Glu1130=)	SNV	Uncertain Significance	331187	rs886054865	GRCh37: 2:136566527-136566527 GRCh38: 2:135808957-135808957
19	LCT	NM_002299.4(LCT):c.643G>A (p.Gly215Arg)	SNV	Uncertain Significance	331208	rs886054869	GRCh37: 2:136590758-136590758 GRCh38: 2:135833188-135833188
20	LCT	NM_002299.4(LCT):c.3599C>T (p.Thr1200Met)	SNV	Uncertain Significance	331184	rs148317168	GRCh37: 2:136566318-136566318 GRCh38: 2:135808748-135808748
21	LCT	NM_002299.4(LCT):c.1045G>A (p.Glu349Lys)	SNV	Uncertain Significance	331205	rs886054868	GRCh37: 2:136575573-136575573 GRCh38: 2:135818003-135818003
22	LCT	NM_002299.4(LCT):c.4646A>G (p.Tyr1549Cys)	SNV	Uncertain Significance	331171	rs147495948	GRCh37: 2:136561517-136561517 GRCh38: 2:135803947-135803947
23	LCT	NM_002299.4(LCT):c.2760C>T (p.Gly920=)	SNV	Uncertain Significance	331194	rs200579267	GRCh37: 2:136567157-136567157 GRCh38: 2:135809587-135809587
24	LCT	NM_002299.4(LCT):c.2763G>A (p.Ala921=)	SNV	Uncertain Significance	331193	rs116951780	GRCh37: 2:136567154-136567154 GRCh38: 2:135809584-135809584
25	LCT	NM_002299.4(LCT):c.5493C>T (p.Tyr1831=)	SNV	Uncertain Significance	331166	rs369410973	GRCh37: 2:136547211-136547211 GRCh38: 2:135789641-135789641
26	LCT	NM_002299.4(LCT):c.2457C>T (p.His819=)	SNV	Uncertain Significance	331196	rs149425549	GRCh37: 2:136567460-136567460 GRCh38: 2:135809890-135809890
27	LCT	NM_002299.4(LCT):c.4922T>C (p.Val1641Ala)	SNV	Uncertain Significance	331167	rs557029000	GRCh37: 2:136555653-136555653 GRCh38: 2:135798083-135798083
28	LCT	NM_002299.4(LCT):c.4122C>T (p.Tyr1374=)	SNV	Uncertain Significance	331179	rs557321611	GRCh37: 2:136564749-136564749 GRCh38: 2:135807179-135807179
29	LCT	NM_002299.4(LCT):c.4239A>G (p.Pro1413=)	SNV	Uncertain Significance	331177	rs752925060	GRCh37: 2:136562562-136562562 GRCh38: 2:135804992-135804992
30	LCT	NM_002299.4(LCT):c.2883C>T (p.Ala961=)	SNV	Uncertain Significance	331192	rs140994860	GRCh37: 2:136567034-136567034 GRCh38: 2:135809464-135809464
31	LCT	NM_002299.4(LCT):c.4576C>T (p.Leu1526=)	SNV	Uncertain Significance	331173	rs140074771	GRCh37: 2:136561587-136561587 GRCh38: 2:135804017-135804017
32	LCT	NM_002299.4(LCT):c.3759G>A (p.Thr1253=)	SNV	Uncertain Significance	331183	rs764860323	GRCh37: 2:136566158-136566158 GRCh38: 2:135808588-135808588
33	LCT	NM_002299.4(LCT):c.4173+6_4173+8del	MICROSAT	Uncertain Significance	331178	rs375300532	GRCh37: 2:136564690-136564692 GRCh38: 2:135807120-135807122
34	LCT	NM_002299.4(LCT):c.1902C>T (p.Pro634=)	SNV	Uncertain Significance	331198	rs202014246	GRCh37: 2:136570332-136570332 GRCh38: 2:135812762-135812762
35	LCT	NM_002299.4(LCT):c.4347T>C (p.Phe1449=)	SNV	Uncertain Significance	331175	rs17699796	GRCh37: 2:136562454-136562454 GRCh38: 2:135804884-135804884
36	LCT	NM_002299.4(LCT):c.3285C>T (p.His1095=)	SNV	Uncertain Significance	331190	rs372534937	GRCh37: 2:136566632-136566632 GRCh38: 2:135809062-135809062
37	LCT	NM_002299.4(LCT):c.3341A>G (p.Gln1114Arg)	SNV	Uncertain Significance	331188	rs148838160	GRCh37: 2:136566576-136566576 GRCh38: 2:135809006-135809006
38	LCT	NM_002299.4(LCT):c.4026G>A (p.Thr1342=)	SNV	Uncertain Significance	331180	rs150640616	GRCh37: 2:136564845-136564845 GRCh38: 2:135807275-135807275
39	LCT	NM_002299.4(LCT):c.1461G>A (p.Ala487=)	SNV	Uncertain Significance	331201	rs146206234	GRCh37: 2:136575157-136575157 GRCh38: 2:135817587-135817587
40	LCT	NM_002299.4(LCT):c.3006G>A (p.Arg1002=)	SNV	Uncertain Significance	331191	rs114815229	GRCh37: 2:136566911-136566911 GRCh38: 2:135809341-135809341
41	LCT	NM_002299.4(LCT):c.1396G>T (p.Gly466Trp)	SNV	Uncertain Significance	331203	rs377102890	GRCh37: 2:136575222-136575222 GRCh38: 2:135817652-135817652
42	LCT	NM_002299.4(LCT):c.621C>T (p.His207=)	SNV	Uncertain Significance	331209	rs369174474	GRCh37: 2:136594119-136594119 GRCh38: 2:135836549-135836549
43	LCT	NM_002299.4(LCT):c.5771T>C (p.Val1924Ala)	SNV	Uncertain Significance	331161	rs886054861	GRCh37: 2:136545907-136545907 GRCh38: 2:135788337-135788337
44	LCT	NM_002299.4(LCT):c.318C>T (p.Asp106=)	SNV	Likely Benign	331213	rs34307240	GRCh37: 2:136594422-136594422 GRCh38: 2:135836852-135836852
45	LCT	NM_002299.4(LCT):c.4777G>A (p.Val1593Met)	SNV	Likely Benign	331169	rs35891837	GRCh37: 2:136558266-136558266 GRCh38: 2:135800696-135800696
46	LCT	NM_002299.4(LCT):c.454G>A (p.Ala152Thr)	SNV	Likely Benign	331211	rs114525655	GRCh37: 2:136594286-136594286 GRCh38: 2:135836716-135836716
47	LCT	NM_002299.4(LCT):c.2714A>G (p.Asp905Gly)	SNV	Likely Benign	331195	rs115690016	GRCh37: 2:136567203-136567203 GRCh38: 2:135809633-135809633
48	LCT	NM_002299.4(LCT):c.729C>G (p.Val243=)	SNV	Likely Benign	331206	rs3816088	GRCh37: 2:136587238-136587238 GRCh38: 2:135829668-135829668
49	LCT	NM_002299.4(LCT):c.5768C>A (p.Pro1923Gln)	SNV	Likely Benign	331162	rs114828879	GRCh37: 2:136545910-136545910 GRCh38: 2:135788340-135788340
50	LCT	NM_002299.4(LCT):c.1650C>G (p.Gly550=)	SNV	Likely Benign	331200	rs35093754	GRCh37: 2:136574968-136574968 GRCh38: 2:135817398-135817398

Sources

Expression for Lactose Intolerance

Search GEO for disease gene expression data for Lactose Intolerance.

Sources

Pathways for Lactose Intolerance

Pathways related to Lactose Intolerance according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.41	PTH INS IL6
2	Digestion and absorption ⁶⁶ Show member pathways Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) ⁶⁶ Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) ⁶⁶ Digestion ⁶⁶ Digestion of dietary carbohydrate ⁶⁶ Digestion of dietary lipid ⁶⁶ Intestinal absorption ⁶⁶ Intestinal hexose absorption ⁶⁶ Intestinal lipid absorption ⁶⁶ Intestinal saccharidase deficiencies ⁶⁶	11.23	SLC2A5 SI LCT
3	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	10.98	IL6 IL10 CRP
4	Diseases of carbohydrate metabolism ⁶⁶ Show member pathways Glycogen storage disease type Ib (SLC37A4) ⁶⁶ Glycogen storage disease type II (GAA) ⁶⁶ Glycogen storage diseases ⁶⁶ Severe congenital neutropenia type 4 (G6PC3) ⁶⁶	10.53	SI LCT GLB1

Sources

GO Terms for Lactose Intolerance

Cellular components related to Lactose Intolerance according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10	TGM2 RECK PTH LALBA INS IL6
2	extracellular space	GO:0005615	9.68	ALB ANPEP ATP4A CRP CSN1S1 CSN2

Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	9.43	INS IL6 CRP
2	carbohydrate metabolic process	GO:0005975	9.1	SLC2A5 SI LCT INS GLB1

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hydrolase activity, acting on glycosyl bonds	GO:0016798	9.43	SI LCT GLB1
2	P-type potassium:proton transporter activity	GO:0008900	9.26	ATP4A ATP12A
3	P-type potassium transmembrane transporter activity	GO:0008556	9.16	ATP4A ATP12A
4	hydrolase activity, hydrolyzing O-glycosyl compounds	GO:0004553	8.92	SI LCT GLB1

Sources

Sources for Lactose Intolerance

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LCT002 MIFTS: 54	Lactose Intolerance Categories: Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
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