Lactose Intolerance

Categories: Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Metabolic diseases
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Aliases & Classifications for Lactose Intolerance

MalaCards integrated aliases for Lactose Intolerance:

Name: Lactose Intolerance 11 42 53 5 41 43 14 63 38 16 71 75 31 33
Lactose Malabsorption 42 33
Intolerance or Malabsorption of Lactose 33
Lm - [lactose Malabsorption] 33
Lm - Lactose Malabsorption 11
Dairy Product Intolerance 42
Milk Sugar Intolerance 42
Cow Milk Enteropathy 33
Milk Intolerance 33
Hypolactasia 42
Alactasia 42


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Disease Ontology 11 DOID:10604
MeSH 43 D007787
NCIt 49 C3154
SNOMED-CT 68 267497007
ICD10 31 E73 E73.9
UMLS 71 C0022951

Summaries for Lactose Intolerance

MedlinePlus Genetics: 42 Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine.Congenital lactase deficiency, also called congenital alactasia, is a disorder in which infants are unable to break down lactose in breast milk or formula. This form of lactose intolerance results in severe diarrhea. If affected infants are not given a lactose-free infant formula, they may develop severe dehydration and weight loss.Lactose intolerance in adulthood is caused by reduced production of lactase after infancy (lactase nonpersistence). If individuals with lactose intolerance consume lactose-containing dairy products, they may experience abdominal pain, bloating, flatulence, nausea, and diarrhea beginning 30 minutes to 2 hours later.Most people with lactase nonpersistence retain some lactase activity and can include varying amounts of lactose in their diets without experiencing symptoms. Often, affected individuals have difficulty digesting fresh milk but can eat certain dairy products such as cheese or yogurt without discomfort. These foods are made using fermentation processes that break down much of the lactose in milk.

MalaCards based summary: Lactose Intolerance, also known as lactose malabsorption, is related to lactose intolerance, adult type and lactase deficiency, congenital, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Digestion and absorption. The drugs Caseins and Mango have been mentioned in the context of this disorder. Affiliated tissues include breast, kidney and small intestine, and related phenotypes are Reduced mammosphere formation and endocrine/exocrine gland

PubMed Health : 63 Lactose intolerance: Stomach ache, bloating, "gas" and diarrhea are all typical digestive symptoms that some people have after eating or drinking dairy products. People who have difficulty digesting dairy products may only tolerate small amounts of lactose (a sugar found in milk and other dairy products). This is called lactose intolerance. But some people who are sensitive to milk might actually have a different problem. It is important to get the diagnosis right before deciding to make major changes to your diet, especially in children, teenagers and people who need more calcium. Lactose intolerance is not an allergy. This is an important difference. People who have a true milk allergy can react to even a tiny amount of dairy foods or milk. But people who are lactose intolerant can sometimes consume quite a lot of these products without having any major problems.

MedlinePlus: 41 Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have: Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Disease Ontology: 11 A carbohydrate metabolic disorder that is characterized by the impaired ability to digest lactose.

Wikipedia: 75 Lactose intolerance is a common condition caused by a decreased ability to digest lactose, a sugar found... more...

Related Diseases for Lactose Intolerance

Diseases in the Lactose Intolerance family:

Lactose Intolerance, Adult Type

Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 lactose intolerance, adult type 32.9 MCM6 LCT
2 lactase deficiency, congenital 32.5 SLC2A5 MCM6 LCT GLB1
3 osmotic diarrhea 31.8 SLC2A5 LCT ATP4A ATP12A
4 diarrhea 31.5 TGM2 SI LCT IL6 IL10 ALB
5 irritable bowel syndrome 30.7 TGM2 LCT IL6 IL10 CRP
6 milk allergy 30.7 LALBA IL10 CSN2 CSN1S1
7 food allergy 30.5 LALBA IL10 CSN1S1
8 immunoglobulin alpha deficiency 30.4 TOR1A TGM2 IL10
9 functional diarrhea 30.4 ATP4A ATP12A
10 kwashiorkor 30.3 INS CRP ALB
11 protein-energy malnutrition 30.3 SI IL6 ALB
12 acute diarrhea 30.3 IL10 CRP ALB
13 blind loop syndrome 30.2 ATP4A ATP12A ALB
14 wheat allergy 30.2 TOR1A TGM2 ALB
15 sucrase-isomaltase deficiency, congenital 30.2 SLC2A5 SI LCT
16 gastroenteritis 30.1 IL6 IL10 CRP ANPEP ALB
17 nutritional deficiency disease 30.1 SI IL6 CRP ATP4A ATP12A ALB
18 marasmus 30.1 INS CRP ALB
19 crohn's colitis 30.1 IL6 IL10 CRP
20 adult syndrome 30.0 INS IL6 CRP
21 graves disease 1 30.0 PTH INS CRP ALB
22 thyroiditis 29.9 INS IL6 IL10 CRP
23 giardiasis 29.9 TOR1A TGM2 LCT IL10 ATP4A ATP12A
24 enterocolitis 29.8 IL6 IL10 CRP
25 duodenal ulcer 29.8 INS IL6 IL10
26 iron deficiency anemia 29.8 IL6 CRP ATP4A
27 brucellosis 29.8 IL6 IL10 CRP
28 crohn's disease 29.8 IL6 IL10 CRP ALB
29 familial mediterranean fever 29.7 IL6 IL10 CRP
30 non-alcoholic steatohepatitis 29.7 INS IL6 ALB
31 allergic disease 29.7 LALBA IL6 IL10 CSN1S1
32 dental caries 29.7 IL6 CSN1S1 CRP ALB
33 mental depression 29.6 INS IL6 IL10 CRP
34 glucose intolerance 29.6 INS IL6 CRP ALB
35 otitis media 29.5 IL6 IL10 CRP ALB
36 arteries, anomalies of 29.5 INS IL6 CRP ALB
37 autoimmune disease 29.5 TGM2 INS IL6 IL10 CRP ANPEP
38 fatty liver disease 29.5 INS IL6 IL10 CRP
39 osteoporosis 29.4 TGM2 PTH LCT INS IL6 IL10
40 dysentery 29.3 SI IL6 IL10 CRP ATP4A ATP12A
41 exanthem 29.3 IL6 IL10 CRP ATP12A ALB
42 anxiety 29.3 INS IL6 IL10 CRP ALB
43 bilirubin metabolic disorder 29.3 INS IL6 IL10 CRP ATP4A ATP12A
44 atherosclerosis susceptibility 29.2 INS IL6 IL10 CRP ALB
45 rectal disease 29.2 IL6 IL10 CRP ATP4A ATP12A ALB
46 perinatal necrotizing enterocolitis 29.1 LALBA IL6 IL10 CSN1S1 CRP ALB
47 peptic ulcer disease 29.0 INS IL6 IL10 CRP ATP4A ATP12A
48 lipoprotein quantitative trait locus 29.0 PTH INS IL6 IL10 CRP ALB
49 cystic fibrosis 29.0 TGM2 INS IL6 IL10 CRP ATP12A
50 bowel dysfunction 28.9 SI PTH LCT INS IL6 IL10

Graphical network of the top 20 diseases related to Lactose Intolerance:

Diseases related to Lactose Intolerance

Symptoms & Phenotypes for Lactose Intolerance

UMLS symptoms related to Lactose Intolerance:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

GenomeRNAi Phenotypes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ALB ANPEP ATP12A ATP4A CRP CSN1S1
2 no effect GR00402-S-2 10.19 ALB ANPEP ATP12A ATP4A CRP CSN1S1
3 Reduced mammosphere formation GR00396-S 9.5 ALB ATP4A GLB1 LALBA MCM6 RECK

MGI Mouse Phenotypes related to Lactose Intolerance:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.4 ALB ANPEP ATP4A CSN1S1 CSN2 IL10

Drugs & Therapeutics for Lactose Intolerance

Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins Phase 4
2 Mango Approved
Turmeric Approved, Experimental, Investigational
4 Orange Approved
Sorbitol Approved, Investigational 69-65-8, 50-70-4 453 6251 5780
Alverine Approved, Investigational 150-59-4 3678
Sodium citrate Approved, Investigational 68-04-2 23431961
Simethicone Approved 8050-81-5
Mebeverine Approved, Investigational 3625-06-7 4031
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8 5280382 445354
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
12 Acidophilus
13 Retinol palmitate
14 Turmeric extract
15 Pharmaceutical Solutions
16 Insulin, Globin Zinc
18 Soy Bean
19 Anti-Infective Agents
20 Antiprotozoal Agents
21 Antiparasitic Agents
22 Antimalarials
23 Sulfalene
24 Cola
25 Parasympatholytics
26 Calcium, Dietary
27 Anticonvulsants
28 Anticoagulants
29 Emollients
30 Dermatologic Agents
31 Citrate
32 Chelating Agents
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Evaluation of the Impact of LacTEST on Diagnostic Thinking and on Patient Management, and of the Reproducibility (Test-Retest), for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance Completed NCT02636413 Phase 4 gaxilose
2 Comparative Effects of Milk With A2 Type Beta Casein Versus Milk With A1 and A2 Beta Casein Proteins on Gastrointestinal Physiology, Symptoms and Cognitive Behavior for the Health People Who Are Intolerant to Traditional Cow Milk Completed NCT02406469 Phase 4
3 Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People Completed NCT02878876 Phase 4
4 A Phase 2b/3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Two Doses of RP-G28 in Subjects With Lactose Intolerance Completed NCT02673749 Phase 2, Phase 3 RP-G28
5 A Phase III, Non-Inferiority, Randomized, Blind, Parallel-Group, Multicentre, Multiple-Dose, Comparative Clinical Study of Lactase Eurofarma and Lactaid®, Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance" Completed NCT01145586 Phase 3 Lactase Oral Tablets
6 A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance Completed NCT03597516 Phase 3 RP-G28;Placebos
7 A Phase III, Non-Inferiority, Randomized, Double-Blind, Parallel-Group, Multicentre, Single-Dose, Comparative Clinical Study of Lactase Eurofarma (Test Drug) and Lactaid® (Comparative Drug), Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance (Hypolactasia) Completed NCT01145339 Phase 3 Lactase
8 Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS. Recruiting NCT05120752 Phase 3
9 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Effectiveness, Safety and Tolerability of RP-G28 in Subjects With Symptoms Associated With Lactose Intolerance Completed NCT01113619 Phase 2 RP-G28 or placebo
10 Prospective, Open-Label, Randomized, Two-Period, Two-Sequence, Crossover Study Comparing RP-G28 Administered in the Fasted State and the Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Volunteers Completed NCT03563846 Phase 1 RP-G28
11 Effect of the Consumption of a Probiotic (B. Bifidum 900791)-Containing Ice-cream in Adult With Hypolactasia and Lactose Intolerance Unknown status NCT03952988
12 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
13 Does Daily Supplementation of Lactobacillus Acidophilus MPH734 (Lacto-FreedomTM, or LF), for One Week, Affects Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation (30-, 60-, and 90- Day) Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo? Unknown status NCT04531033
14 Effect of Whole Milk Intake on the Cardio-metabolic Risk Factors of Healthy Person With or Without Lactose Maldigestion Unknown status NCT02798718
15 Nutritional Clinical Trial to Evaluate the Regular Consumption Effect of a Probiotic With High Beta-galactosidase Activity Over Lactose Intolerance Gastrointestinal Symptoms in Patients With Lactose Intolerance Completed NCT05367453
16 Efficacy of Probiotic I31 on Symptomatic Improvement in Patients With Lactose Intolerance Completed NCT04164394
17 Evaluation of GIMate Handheld Hydrogen Breath Monitor for Diagnosis of Lactose Malabsorption Completed NCT04754724
18 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People. Completed NCT00395954
19 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People Who Also Have Ulcerative Colitis Completed NCT00403923
20 Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution: Randomized, Double-blind, Placebo-controlled, Positive-controlled, Three-way Crossover, Acute Lactose Challenge Completed NCT03814668
21 A Randomized, Controlled, Double-blind, Cross-over, Single-centre Study to Investigate the Effect of a Fermented Infant Formula on Lactose Digestion in Lactose Intolerant Adults Completed NCT02703987
22 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
23 Clinical Utility of Carbohydrate Breath Tests in Unexplained GI Symptoms Completed NCT03261856
24 Differential Biologic Impact of Lactose Consumption in Lactase Persistent and Non-persistent Populations: Evaluation of Microflora and Insulin/Glycemic Response Completed NCT00599859
25 Comparison of Raw Milk Consumption vs. Other Milk Sources on Lactose Digestion in Healthy Individuals With Self-reported Lactose Intolerance Completed NCT01129791
26 β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion: Probiotic and Lactose Intolerance Completed NCT02518295
27 Modulation of Lactase Expression by a New Synthetic PPARgamma Ligand in Ex-vivo Cultures of Duodenal Biopsies Completed NCT02902016 GED
28 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
29 Understanding Perceived Lactose Intolerance in White, Black, and Hispanic Adults Completed NCT01331265
30 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Completed NCT03008252
31 Secondary Lactose Intolerance Due to Chronic Norovirus Infection in Renal Transplant Recipients Completed NCT01840891
32 Effects of A2 Milk on Gastrointestinal Function of Volunteers Affected by Non-lactose Milk Intolerance Completed NCT03060395
33 A Combination of Yoghurt Bacteria and Acid Lactase From Aspergillus Oryzae Improves Lactose Digestion in Lactose Malabsorbers More Reliably Than Preparations Containing Acid Lactase or Yoghurt Bacteria Alone Completed NCT01593631
34 Comparison of Two Extensively Hydrolyzed Formulas for the Treatment of Children With Cow's Milk Intolerance Completed NCT01727115
35 Association Between Lactase Deficiency, Symptoms of Lactose Intolerance, and the Small Intestinal Microbiome in Adults Recruiting NCT03860051
36 Fructose and Lactose Intolerance and Malabsorption: the Relationship Between Metabolism and Symptoms in Functional Gastrointestinal Disorders Recruiting NCT02085889
37 Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyses A1 Milk Recruiting NCT05305391
38 The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION Trial): Protocol of a Multicentre Randomized Controlled Clinical Trial Not yet recruiting NCT05100719 alverine-citrate + simethicone and lactase;alverin-citrate + simethicone with placebo
39 Prevalence of Lactose Intolerance Following Stem Cell Transplantation in Pediatric Patients. Terminated NCT00247806
40 A Study to Validate a Home-screening Test for Lactose Intolerant People Withdrawn NCT00844766

Search NIH Clinical Center for Lactose Intolerance

Cochrane evidence based reviews: lactose intolerance

Genetic Tests for Lactose Intolerance

Anatomical Context for Lactose Intolerance

Organs/tissues related to Lactose Intolerance:

MalaCards : Breast, Kidney, Small Intestine, Bone, Colon, Heart, Amygdala

Publications for Lactose Intolerance

Articles related to Lactose Intolerance:

(show top 50) (show all 2338)
# Title Authors PMID Year
The Perception of Lactose-Related Symptoms of Patients with Lactose Malabsorption. 62 41
36011869 2022
Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose. 62 41
35893871 2022
Serum and Urine Metabolites in Healthy Men after Consumption of Acidified Milk and Yogurt. 41
36432479 2022
Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population. 53 62
18980667 2008
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. 53 62
17651714 2007
Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? 53 62
17574225 2007
Hypolactasia as a molecular basis of lactose intolerance. 53 62
17133732 2006
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase. 53 62
17190185 2006
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. 53 62
16301215 2005
The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. 53 62
12795467 2003
Identification of a variant associated with adult-type hypolactasia. 53 62
11788828 2002
Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. 53 62
11332711 2001
[Idiopathic thrombocytopenic purpura and food allergy: a study on possible correlations]. 53 62
10335541 1998
Antibodies to lactoferrin--a possible link between cow's milk intolerance and autoimmune disease. 53 62
9191361 1997
Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes. 53 62
1976654 1990
Streptomyces genus as a source of probiotics and its potential for its use in health. 62
36335804 2023
Revealing Joseon period People's single nucleotide polymorphism associated with lactase gene by ancient DNA analysis of human remains from archaeological sites in Korea. 62
36450657 2022
Small Intestinal Bacterial Overgrowth in Patients with Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass. 62
36197573 2022
The use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals. 62
36308983 2022
Relationships of Intestinal Lactase and the Small Intestinal Microbiome with Symptoms of Lactose Intolerance and Intake in Adults. 62
35322314 2022
White as milk: Biocentric bias in the framing of lactose intolerance and lactase persistence. 62
36018892 2022
Cow's milk-induced gastrointestinal disorders: From infancy to adulthood. 62
36439902 2022
Lactose Content and Selected Quality Parameters of Sheep Milk Fermented Beverages during Storage. 62
36428333 2022
Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population. 62
36129808 2022
Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women. 62
36364729 2022
Effects of Probiotic Fermented Fruit Juice-Based Biotransformation by Lactic Acid Bacteria and Saccharomyces boulardii CNCM I-745 on Anti-Salmonella and Antioxidative Properties. 62
36198663 2022
Chronic diarrhea - The poetic masquerade. 62
36348608 2022
Benefits of Flavored Lactose-Free Milk for Korean Adults with Lactose Intolerance. 62
36179067 2022
Bacterial overgrowth and lactose intolerance: how to best assess. 62
35838278 2022
Bifidobacterium Animalis Subsp. Lactis Bi-07 Supports Lactose Digestion in Vitro and in Randomized, Placebo and Lactase -controlled Clinical Trials. 62
36149331 2022
Development of probiotics beverage using cereal enzymatic hydrolysate fermented with Limosilactobacillus reuteri. 62
36171765 2022
The stressing life of Lactobacillus delbrueckii subsp. bulgaricus in soy milk. 62
35690436 2022
Probiotication of Nutritious Fruit and Vegetable Juices: An Alternative to Dairy-Based Probiotic Functional Products. 62
36079714 2022
Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities. 62
35713579 2022
Terahertz Spectroscopic Analysis of Lactose in Infant Formula: Implications for Detection and Quantification. 62
35956992 2022
Switching from the tablet to the powder formulation of levothyroxine corrects severe hypothyroidism in a patient with lactose intolerance. 62
35249899 2022
Efficacy and Safety of a Novel Therapeutic of Natural Origin (NTN) in Adult Patients with Lactose Intolerance: A Multicenter, Randomized, Crossover, Double-Blind, Placebo-Controlled Study. 62
36076786 2022
Sixty seconds on . . . lactose intolerance. 62
35905988 2022
Effects of different combinations of probiotics on rheology, microstructure, and moisture distribution of soy materials-based yogurt. 62
35638330 2022
Functional Fermented Probiotics, Prebiotics, and Synbiotics from Non-Dairy Products: A Perspective from Nutraceutical. 62
35616160 2022
Ultrasonic analysis of effects of varying temperature, pH, and proteolytic enzymes on hydrolysis of lactose by neutral lactase formulations in infant milk and in the infant digestive system. 62
35761512 2022
Cloning, Expression, Purification, and Characterization of β-Galactosidase from Bifidobacterium longum and Bifidobacterium pseudocatenulatum. 62
35889370 2022
Validation of a modified cow's milk-related symptom score (CoMISS) for screening of lactose intolerance in adults. 62
35318881 2022
Awareness of Lactose Intolerance Disorder in Saudi Arabia Population. 62
36119262 2022
Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults. 62
35695459 2022
Lactose: Characteristics, Food and Drug-Related Applications, and Its Possible Substitutions in Meeting the Needs of People with Lactose Intolerance. 62
35627056 2022
International Cross-Sectional Survey among Healthcare Professionals on the Management of Cow's Milk Protein Allergy and Lactose Intolerance in Infants and Children. 62
35611371 2022
Lactose Intolerance and Its Dietary Management: An Update. 62
33831336 2022
Gastrointestinal Conditions: Malabsorption Syndromes. 62
35507311 2022
The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? 62
35676992 2022

Variations for Lactose Intolerance

ClinVar genetic disease variations for Lactose Intolerance:

5 (show top 50) (show all 61)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LCT NM_002299.4(LCT):c.54G>C (p.Trp18Cys) SNV Uncertain Significance
331214 rs886054870 GRCh37: 2:136594686-136594686
GRCh38: 2:135837116-135837116
2 LCT NM_002299.4(LCT):c.4434T>C (p.Asp1478=) SNV Uncertain Significance
331174 rs778761405 GRCh37: 2:136562367-136562367
GRCh38: 2:135804797-135804797
3 LCT NM_002299.4(LCT):c.*251G>A SNV Uncertain Significance
331157 rs886054860 GRCh37: 2:136545643-136545643
GRCh38: 2:135788073-135788073
4 LCT NM_002299.4(LCT):c.2177G>A (p.Arg726His) SNV Uncertain Significance
331197 rs886054866 GRCh37: 2:136570057-136570057
GRCh38: 2:135812487-135812487
5 LCT NM_002299.4(LCT):c.319G>A (p.Glu107Lys) SNV Uncertain Significance
331212 rs761296720 GRCh37: 2:136594421-136594421
GRCh38: 2:135836851-135836851
6 LCT NM_002299.4(LCT):c.4695C>T (p.Tyr1565=) SNV Uncertain Significance
331170 rs886054862 GRCh37: 2:136558348-136558348
GRCh38: 2:135800778-135800778
7 LCT NM_002299.4(LCT):c.*10A>C SNV Uncertain Significance
331160 rs200994158 GRCh37: 2:136545884-136545884
GRCh38: 2:135788314-135788314
8 LCT NM_002299.4(LCT):c.5656G>A (p.Val1886Ile) SNV Uncertain Significance
331163 rs376732886 GRCh37: 2:136546022-136546022
GRCh38: 2:135788452-135788452
9 LCT NM_002299.4(LCT):c.3595G>A (p.Ala1199Thr) SNV Uncertain Significance
331185 rs886054863 GRCh37: 2:136566322-136566322
GRCh38: 2:135808752-135808752
10 LCT NM_002299.4(LCT):c.*230T>C SNV Uncertain Significance
331158 rs749324196 GRCh37: 2:136545664-136545664
GRCh38: 2:135788094-135788094
11 LCT NM_002299.4(LCT):c.*325G>C SNV Uncertain Significance
331156 rs62170085 GRCh37: 2:136545569-136545569
GRCh38: 2:135787999-135787999
12 LCT NM_002299.4(LCT):c.3532C>T (p.Leu1178=) SNV Uncertain Significance
331186 rs886054864 GRCh37: 2:136566385-136566385
GRCh38: 2:135808815-135808815
13 LCT NM_002299.4(LCT):c.1780C>G (p.Gln594Glu) SNV Uncertain Significance
331199 rs886054867 GRCh37: 2:136570454-136570454
GRCh38: 2:135812884-135812884
14 LCT NM_002299.4(LCT):c.3286G>A (p.Ala1096Thr) SNV Uncertain Significance
331189 rs146467199 GRCh37: 2:136566631-136566631
GRCh38: 2:135809061-135809061
15 LCT NM_002299.4(LCT):c.3986C>T (p.Thr1329Met) SNV Uncertain Significance
331181 rs555708380 GRCh37: 2:136564885-136564885
GRCh38: 2:135807315-135807315
16 LCT NM_002299.4(LCT):c.3848C>T (p.Thr1283Met) SNV Uncertain Significance
331182 rs147755711 GRCh37: 2:136566069-136566069
GRCh38: 2:135808499-135808499
17 LCT NM_002299.4(LCT):c.5529C>T (p.Pro1843=) SNV Uncertain Significance
331165 rs761696901 GRCh37: 2:136547175-136547175
GRCh38: 2:135789605-135789605
18 LCT NM_002299.4(LCT):c.3390G>A (p.Glu1130=) SNV Uncertain Significance
331187 rs886054865 GRCh37: 2:136566527-136566527
GRCh38: 2:135808957-135808957
19 LCT NM_002299.4(LCT):c.643G>A (p.Gly215Arg) SNV Uncertain Significance
331208 rs886054869 GRCh37: 2:136590758-136590758
GRCh38: 2:135833188-135833188
20 LCT NM_002299.4(LCT):c.3599C>T (p.Thr1200Met) SNV Uncertain Significance
331184 rs148317168 GRCh37: 2:136566318-136566318
GRCh38: 2:135808748-135808748
21 LCT NM_002299.4(LCT):c.1045G>A (p.Glu349Lys) SNV Uncertain Significance
331205 rs886054868 GRCh37: 2:136575573-136575573
GRCh38: 2:135818003-135818003
22 LCT NM_002299.4(LCT):c.4646A>G (p.Tyr1549Cys) SNV Uncertain Significance
331171 rs147495948 GRCh37: 2:136561517-136561517
GRCh38: 2:135803947-135803947
23 LCT NM_002299.4(LCT):c.2760C>T (p.Gly920=) SNV Uncertain Significance
331194 rs200579267 GRCh37: 2:136567157-136567157
GRCh38: 2:135809587-135809587
24 LCT NM_002299.4(LCT):c.2763G>A (p.Ala921=) SNV Uncertain Significance
331193 rs116951780 GRCh37: 2:136567154-136567154
GRCh38: 2:135809584-135809584
25 LCT NM_002299.4(LCT):c.5493C>T (p.Tyr1831=) SNV Uncertain Significance
331166 rs369410973 GRCh37: 2:136547211-136547211
GRCh38: 2:135789641-135789641
26 LCT NM_002299.4(LCT):c.2457C>T (p.His819=) SNV Uncertain Significance
331196 rs149425549 GRCh37: 2:136567460-136567460
GRCh38: 2:135809890-135809890
27 LCT NM_002299.4(LCT):c.4922T>C (p.Val1641Ala) SNV Uncertain Significance
331167 rs557029000 GRCh37: 2:136555653-136555653
GRCh38: 2:135798083-135798083
28 LCT NM_002299.4(LCT):c.4122C>T (p.Tyr1374=) SNV Uncertain Significance
331179 rs557321611 GRCh37: 2:136564749-136564749
GRCh38: 2:135807179-135807179
29 LCT NM_002299.4(LCT):c.4239A>G (p.Pro1413=) SNV Uncertain Significance
331177 rs752925060 GRCh37: 2:136562562-136562562
GRCh38: 2:135804992-135804992
30 LCT NM_002299.4(LCT):c.2883C>T (p.Ala961=) SNV Uncertain Significance
331192 rs140994860 GRCh37: 2:136567034-136567034
GRCh38: 2:135809464-135809464
31 LCT NM_002299.4(LCT):c.4576C>T (p.Leu1526=) SNV Uncertain Significance
331173 rs140074771 GRCh37: 2:136561587-136561587
GRCh38: 2:135804017-135804017
32 LCT NM_002299.4(LCT):c.3759G>A (p.Thr1253=) SNV Uncertain Significance
331183 rs764860323 GRCh37: 2:136566158-136566158
GRCh38: 2:135808588-135808588
33 LCT NM_002299.4(LCT):c.4173+6_4173+8del MICROSAT Uncertain Significance
331178 rs375300532 GRCh37: 2:136564690-136564692
GRCh38: 2:135807120-135807122
34 LCT NM_002299.4(LCT):c.1902C>T (p.Pro634=) SNV Uncertain Significance
331198 rs202014246 GRCh37: 2:136570332-136570332
GRCh38: 2:135812762-135812762
35 LCT NM_002299.4(LCT):c.4347T>C (p.Phe1449=) SNV Uncertain Significance
331175 rs17699796 GRCh37: 2:136562454-136562454
GRCh38: 2:135804884-135804884
36 LCT NM_002299.4(LCT):c.3285C>T (p.His1095=) SNV Uncertain Significance
331190 rs372534937 GRCh37: 2:136566632-136566632
GRCh38: 2:135809062-135809062
37 LCT NM_002299.4(LCT):c.3341A>G (p.Gln1114Arg) SNV Uncertain Significance
331188 rs148838160 GRCh37: 2:136566576-136566576
GRCh38: 2:135809006-135809006
38 LCT NM_002299.4(LCT):c.4026G>A (p.Thr1342=) SNV Uncertain Significance
331180 rs150640616 GRCh37: 2:136564845-136564845
GRCh38: 2:135807275-135807275
39 LCT NM_002299.4(LCT):c.1461G>A (p.Ala487=) SNV Uncertain Significance
331201 rs146206234 GRCh37: 2:136575157-136575157
GRCh38: 2:135817587-135817587
40 LCT NM_002299.4(LCT):c.3006G>A (p.Arg1002=) SNV Uncertain Significance
331191 rs114815229 GRCh37: 2:136566911-136566911
GRCh38: 2:135809341-135809341
41 LCT NM_002299.4(LCT):c.1396G>T (p.Gly466Trp) SNV Uncertain Significance
331203 rs377102890 GRCh37: 2:136575222-136575222
GRCh38: 2:135817652-135817652
42 LCT NM_002299.4(LCT):c.621C>T (p.His207=) SNV Uncertain Significance
331209 rs369174474 GRCh37: 2:136594119-136594119
GRCh38: 2:135836549-135836549
43 LCT NM_002299.4(LCT):c.5771T>C (p.Val1924Ala) SNV Uncertain Significance
331161 rs886054861 GRCh37: 2:136545907-136545907
GRCh38: 2:135788337-135788337
44 LCT NM_002299.4(LCT):c.318C>T (p.Asp106=) SNV Likely Benign
331213 rs34307240 GRCh37: 2:136594422-136594422
GRCh38: 2:135836852-135836852
45 LCT NM_002299.4(LCT):c.4777G>A (p.Val1593Met) SNV Likely Benign
331169 rs35891837 GRCh37: 2:136558266-136558266
GRCh38: 2:135800696-135800696
46 LCT NM_002299.4(LCT):c.454G>A (p.Ala152Thr) SNV Likely Benign
331211 rs114525655 GRCh37: 2:136594286-136594286
GRCh38: 2:135836716-135836716
47 LCT NM_002299.4(LCT):c.2714A>G (p.Asp905Gly) SNV Likely Benign
331195 rs115690016 GRCh37: 2:136567203-136567203
GRCh38: 2:135809633-135809633
48 LCT NM_002299.4(LCT):c.729C>G (p.Val243=) SNV Likely Benign
331206 rs3816088 GRCh37: 2:136587238-136587238
GRCh38: 2:135829668-135829668
49 LCT NM_002299.4(LCT):c.5768C>A (p.Pro1923Gln) SNV Likely Benign
331162 rs114828879 GRCh37: 2:136545910-136545910
GRCh38: 2:135788340-135788340
50 LCT NM_002299.4(LCT):c.1650C>G (p.Gly550=) SNV Likely Benign
331200 rs35093754 GRCh37: 2:136574968-136574968
GRCh38: 2:135817398-135817398

Expression for Lactose Intolerance

Search GEO for disease gene expression data for Lactose Intolerance.

Pathways for Lactose Intolerance

GO Terms for Lactose Intolerance

Cellular components related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TGM2 RECK PTH LALBA INS IL6
2 extracellular space GO:0005615 9.68 ALB ANPEP ATP4A CRP CSN1S1 CSN2

Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.43 INS IL6 CRP
2 carbohydrate metabolic process GO:0005975 9.1 SLC2A5 SI LCT INS GLB1

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.43 SI LCT GLB1
2 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
3 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
4 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.92 SI LCT GLB1

Sources for Lactose Intolerance

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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