MCID: LCT002
MIFTS: 53

Lactose Intolerance

Categories: Gastrointestinal diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Lactose Intolerance

MalaCards integrated aliases for Lactose Intolerance:

Name: Lactose Intolerance 12 25 54 6 42 43 15 62 39 17 71 32
Lm - Lactose Malabsorption 12
Dairy Product Intolerance 25
Milk Sugar Intolerance 25
Lactose Malabsorption 25
Hypolactasia 25
Alactasia 25

Classifications:



External Ids:

Disease Ontology 12 DOID:10604
MeSH 43 D007787
NCIt 49 C3154
ICD10 32 E73 E73.9
UMLS 71 C0022951

Summaries for Lactose Intolerance

Genetics Home Reference : 25 Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine. Congenital lactase deficiency, also called congenital alactasia, is a disorder in which infants are unable to break down lactose in breast milk or formula. This form of lactose intolerance results in severe diarrhea. If affected infants are not given a lactose-free infant formula, they may develop severe dehydration and weight loss. Lactose intolerance in adulthood is caused by reduced production of lactase after infancy (lactase nonpersistence). If individuals with lactose intolerance consume lactose-containing dairy products, they may experience abdominal pain, bloating, flatulence, nausea, and diarrhea beginning 30 minutes to 2 hours later. Most people with lactase nonpersistence retain some lactase activity and can include varying amounts of lactose in their diets without experiencing symptoms. Often, affected individuals have difficulty digesting fresh milk but can eat certain dairy products such as cheese or yogurt without discomfort. These foods are made using fermentation processes that break down much of the lactose in milk.

MalaCards based summary : Lactose Intolerance, also known as lm - lactose malabsorption, is related to lactose intolerance, adult type and diarrhea, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Galactose metabolism. The drugs Methadone and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and small intestine, and related phenotype is renal/urinary system.

MedlinePlus : 42 Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

PubMed Health : 62 About lactose intolerance: Stomach ache, bloating, "gas" and diarrhea are all typical digestive symptoms that some people have after eating or drinking dairy products. People who have difficulty digesting dairy products may only tolerate small amounts of lactose (a sugar found in milk and other dairy products). This is called lactose intolerance. But some people who are sensitive to milk might actually have a different problem. It is important to get the diagnosis right before deciding to make major changes to your diet, especially in children, teenagers and people who need more calcium. Lactose intolerance is not an allergy. This is an important difference. People who have a true milk allergy can react to even a tiny amount of dairy foods or milk. But people who are lactose intolerant can sometimes consume quite a lot of these products without having any major problems.

Wikipedia : 74 Lactose intolerance is when a person has symptoms due to a decreased ability to digest lactose, a sugar... more...

Related Diseases for Lactose Intolerance

Diseases in the Lactose Intolerance family:

Lactose Intolerance, Adult Type

Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 lactose intolerance, adult type 35.0 MCM6 LCT
2 diarrhea 32.7 TGM2 SI LCT ALB
3 gastroenteritis 30.7 CRP ANPEP ALB
4 eosinophilic gastroenteritis 30.2 ATP4A ATP12A ALB
5 peptic ulcer disease 30.2 ATP4A ATP12A ALB
6 kwashiorkor 30.1 INS CRP ALB
7 dysentery 29.9 CRP ATP4A ATP12A ALB
8 giardiasis 29.9 TOR1A TGM2 LCT ATP4A ATP12A ALB
9 nutritional deficiency disease 29.7 CRP ATP4A ATP12A ALB
10 dental caries 29.2 VDR CRP ALB
11 celiac disease 1 29.0 TOR1A TGM2 PTH LCT INS CRP
12 osteoporosis 28.8 VDR TGM2 PTH LCT INS CRP
13 deficiency anemia 28.7 PTH INS CRP ATP4A ATP12A ANPEP
14 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 12.6
15 lactase deficiency, congenital 12.4
16 congenital short bowel syndrome 11.4
17 osmotic diarrhea 11.4
18 short bowel syndrome 11.4
19 streptococcal group a invasive disease 11.4
20 irritable bowel syndrome 10.8
21 overgrowth syndrome 10.5
22 pancreatic vasoactive intestinal peptide producing tumor 10.5 ATP4A ATP12A
23 hemangioma of intra-abdominal structure 10.5 ATP4A ATP12A
24 displacement of cardia through esophageal hiatus 10.5 ATP4A ATP12A
25 gastric hemangioma 10.5 ATP4A ATP12A
26 acquired gastric outlet stenosis 10.5 ATP4A ATP12A
27 angiodysplasia of intestine 10.5 ATP4A ATP12A
28 bone mineral density quantitative trait locus 8 10.5
29 bone mineral density quantitative trait locus 15 10.5
30 median arcuate ligament syndrome 10.5 ATP4A ATP12A
31 granulomatous gastritis 10.5 ATP4A ATP12A
32 bacterial esophagitis 10.5 ATP4A ATP12A
33 lingual goiter 10.5 ATP4A ATP12A
34 cascade stomach 10.5 ATP4A ATP12A
35 gastrojejunal ulcer 10.5 ATP4A ATP12A
36 fungal esophagitis 10.5 ATP4A ATP12A
37 gastric gastrinoma 10.5 ATP4A ATP12A
38 fungal gastritis 10.5 ATP4A ATP12A
39 cervix erosion 10.5 ATP4A ATP12A
40 jejunoileitis 10.5 TOR1A TGM2
41 dieulafoy lesion 10.5 ATP4A ATP12A
42 esophagus sarcoma 10.5 ATP4A ATP12A
43 esophagus melanoma 10.5 ATP4A ATP12A
44 central nervous system origin vertigo 10.4 ATP4A ATP12A
45 chronic laryngitis 10.4 ATP4A ATP12A
46 cefuroxime allergy 10.4 ATP4A ATP12A
47 gluten allergy 10.4 TOR1A TGM2
48 constipation 10.4
49 gastroduodenitis 10.4 ATP4A ATP12A
50 chronic intestinal vascular insufficiency 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Lactose Intolerance:



Diseases related to Lactose Intolerance

Symptoms & Phenotypes for Lactose Intolerance

UMLS symptoms related to Lactose Intolerance:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Lactose Intolerance:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 ALB ATP12A GLB1 INS TGM2 TREH

Drugs & Therapeutics for Lactose Intolerance

Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methadone Approved Phase 4 76-99-3 4095
2
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
5
protease inhibitors Phase 4
6 HIV Protease Inhibitors Phase 4
7 Serine Proteinase Inhibitors Phase 4
8 Alpha 1-Antitrypsin Phase 4
9 Trypsin Inhibitors Phase 4
10 Protein C Inhibitor Phase 4
11 Bifidobacterium Phase 4
12 Narcotics Phase 4
13 Respiratory System Agents Phase 4
14 Analgesics, Opioid Phase 4
15 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
16 Opiate Alkaloids Phase 4
17 Antitussive Agents Phase 4
18
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
19
Histamine Approved, Investigational Phase 3 51-45-6 774
20
Ketotifen Approved Phase 3 34580-13-7, 34580-14-8 3827
21 Acidophilus Phase 3
22 Histamine Antagonists Phase 3
23 Dermatologic Agents Phase 3
24 Antipruritics Phase 3
25 Histamine H1 Antagonists Phase 3
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Anti-Allergic Agents Phase 3
28
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
29
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
30
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
31 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
32
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
33
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
34
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
35
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
36
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
37
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
38 Calcium, Dietary Phase 2
39 Nutrients Phase 2
40 Insulin, Globin Zinc Phase 1, Phase 2
41 insulin Phase 1, Phase 2
42 Gastrointestinal Agents Phase 2
43 Hormones Phase 2
44 Micronutrients Phase 2
45 Vitamins Phase 2
46 Trace Elements Phase 2
47 Ergocalciferols Phase 2
48 Vitamin D2 Phase 2
49 Calciferol Phase 2
50 Liver Extracts Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Evaluation of the Impact of LacTEST on Diagnostic Thinking and on Patient Management, and of the Reproducibility (Test-Retest), for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance Completed NCT02636413 Phase 4 gaxilose
2 Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People Completed NCT02878876 Phase 4
3 Comparative Effects of Milk With A2 Type Beta Casein Versus Milk With A1 and A2 Beta Casein Proteins on Gastrointestinal Physiology, Symptoms and Cognitive Behavior for the Health People Who Are Intolerant to Traditional Cow Milk Completed NCT02406469 Phase 4
4 Evaluation of Efficacy of Methadone Versus Morphine for Treatment of Neonatal Abstinence Syndrome (NAS). Completed NCT01804075 Phase 4 Methadone;Morphine
5 Effects of an Association of the Two Bifidobacteria Probiotics Bifidobacterium Breve B632 and Bifidobacterium Breve BR03 in Intestinal Bacterial Colonization and in the Prevention and/or Reduction of the Incidence of Colics in Infants Completed NCT03219931 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
6 Therapeutic Effects of Mesalamine and Amitriptyline in IBS: a Randomized Clinical Trial Withdrawn NCT02190526 Phase 4 Mesalazine(asacol 800 mg);Amitriptyline;placebo like asacol;placebo like amitriptyline
7 A Phase III, Non-Inferiority, Randomized, Double-Blind, Parallel-Group, Multicentre, Single-Dose, Comparative Clinical Study of Lactase Eurofarma (Test Drug) and Lactaid® (Comparative Drug), Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance (Hypolactasia) Completed NCT01145339 Phase 3 Lactase
8 A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance Completed NCT03597516 Phase 3 RP-G28;Placebos
9 A Phase III, Non-Inferiority, Randomized, Blind, Parallel-Group, Multicentre, Multiple-Dose, Comparative Clinical Study of Lactase Eurofarma and Lactaid®, Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance" Completed NCT01145586 Phase 3 Lactase Oral Tablets
10 A Phase 2b/3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Two Doses of RP-G28 in Subjects With Lactose Intolerance Completed NCT02673749 Phase 2, Phase 3 RP-G28
11 Decreasing Rates of Illnesses in Kids (DRINK) Completed NCT00356382 Phase 3 Lactobacillus (L.) casei
12 Randomized Controlled Trial of a Reduced Carbohydrate Formulation of F75 Therapeutic Milk Among Children With Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
13 PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2 Recruiting NCT03582176 Phase 3 Lactose Placebo;Ketotifen Fumarate 2mg;Ketotifen Fumarate 5mg
14 Cow's Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula (TeHF2013-01) in Infants With Confirmed Cow's Milk Protein Allergy Unknown status NCT02149134 Phase 2
15 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Effectiveness, Safety and Tolerability of RP-G28 in Subjects With Symptoms Associated With Lactose Intolerance Completed NCT01113619 Phase 2 RP-G28 or placebo;RP-G28 or placebo
16 Safe and Effective Vitamin D Supplementation in HIV Completed NCT01092338 Phase 2 Cholecalciferol (Vit D3)
17 A Double-Blind, Randomized, Placebo-Controlled Multicenter Study to Assess the Safety and Efficacy of AST-120 in Patients With Non-Constipating Irritable Bowel Syndrome Completed NCT00583128 Phase 2 AST-120;Celphere® CP-305
18 Influence of the Consumption of Milk Drink With Bifidobacterium Animalis in Symptoms of Constipation. Completed NCT02091115 Phase 1, Phase 2
19 Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease Completed NCT01016418 Phase 1, Phase 2
20 Efficacy of Combination Therapy of Glucocorticoids, and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis: A Pilot Study. Completed NCT02265328 Phase 2
21 Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of Kefir Terminated NCT02707198 Phase 2 kefir
22 Prospective, Open-Label, Randomized, Two-Period, Two-Sequence, Crossover Study Comparing RP-G28 Administered in the Fasted State and the Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Volunteers Completed NCT03563846 Phase 1 RP-G28
23 Probiotic Ingestion and Isoagglutinin Titers Completed NCT00891787 Phase 1
24 Effect of Whole Milk Intake on the Cardio-metabolic Risk Factors of Healthy Person With or Without Lactose Maldigestion Unknown status NCT02798718
25 Clinical Utility of Carbohydrate Breath Tests in Unexplained GI Symptoms Unknown status NCT03261856
26 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
27 An Audit on Management of Chronic Diarrhea Unknown status NCT03269305
28 Building Better Bones in Children Unknown status NCT00063037
29 64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings Unknown status NCT02231047
30 A Randomised, Controlled, Parallel Study to Determine the Immunomodulatory Effects of Pre- and Probiotics Upon the Immune Response to Influenza Vaccination in Young and Older Volunteers Unknown status NCT01066377
31 The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1 Unknown status NCT02644590 Early Phase 1 Melatonin
32 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
33 A Combination of Yoghurt Bacteria and Acid Lactase From Aspergillus Oryzae Improves Lactose Digestion in Lactose Malabsorbers More Reliably Than Preparations Containing Acid Lactase or Yoghurt Bacteria Alone Completed NCT01593631
34 Understanding Perceived Lactose Intolerance in White, Black, and Hispanic Adults Completed NCT01331265
35 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
36 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People. Completed NCT00395954
37 A Randomized, Controlled, Double-blind, Cross-over, Single-centre Study to Investigate the Effect of a Fermented Infant Formula on Lactose Digestion in Lactose Intolerant Adults Completed NCT02703987
38 Modulation of Lactase Expression by a New Synthetic PPARgamma Ligand in Ex-vivo Cultures of Duodenal Biopsies Completed NCT02902016 GED
39 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People Who Also Have Ulcerative Colitis Completed NCT00403923
40 β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion: Probiotic and Lactose Intolerance Completed NCT02518295
41 Comparison of Raw Milk Consumption vs. Other Milk Sources on Lactose Digestion in Healthy Individuals With Self-reported Lactose Intolerance Completed NCT01129791
42 Comparison of Two Extensively Hydrolyzed Formulas for the Treatment of Children With Cow's Milk Intolerance Completed NCT01727115
43 Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution: Randomized, Double-blind, Placebo-controlled, Positive-controlled, Three-way Crossover, Acute Lactose Challenge Completed NCT03814668
44 Secondary Lactose Intolerance Due to Chronic Norovirus Infection in Renal Transplant Recipients Completed NCT01840891
45 Prospective Assessment of High Titre TTG to Diagnose Celiac Disease in Select Paediatric Patients. Completed NCT00175760
46 Differential Biologic Impact of Lactose Consumption in Lactase Persistent and Non-persistent Populations: Evaluation of Microflora and Insulin/Glycemic Response Completed NCT00599859
47 The Effects of Rifaximin Therapy in Patients Pre-Diagnosed With Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo Controlled Study Completed NCT02009618 Rifaximin;placebo
48 Calcium Bioavailability of Cassia Leaves in Post-Menopausal Women Completed NCT02291315
49 Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance? Completed NCT01705171
50 Confocal Endomicrosopy for the Detection of Food Intolerance in Patients With Irritable Bowel Syndrome Completed NCT01692613

Search NIH Clinical Center for Lactose Intolerance

Cochrane evidence based reviews: lactose intolerance

Genetic Tests for Lactose Intolerance

Anatomical Context for Lactose Intolerance

MalaCards organs/tissues related to Lactose Intolerance:

40
Testes, Bone, Small Intestine, Colon, Breast, Kidney, Liver

Publications for Lactose Intolerance

Articles related to Lactose Intolerance:

(show top 50) (show all 1315)
# Title Authors PMID Year
1
Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. 61 42
31427404 2019
2
Lactose Intolerance. 61 42
31638683 2019
3
ANALYSIS OF LACTOSE INTOLERANCE IN STUDENTS WITH SUGGESTIVE SYMPTOMS OF IRRITABLE BOWEL SYNDROME. 61 42
31633730 2019
4
Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population. 54 61
18980667 2008
5
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. 54 61
17651714 2007
6
Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? 54 61
17574225 2007
7
Hypolactasia as a molecular basis of lactose intolerance. 54 61
17133732 2006
8
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase. 54 61
17190185 2006
9
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. 54 61
16301215 2005
10
The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. 54 61
12795467 2003
11
Identification of a variant associated with adult-type hypolactasia. 54 61
11788828 2002
12
Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. 54 61
11332711 2001
13
Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes. 54 61
1976654 1990
14
Carboxymethylpachymaran-zein coated plant microcapsules-based β-galactosidase encapsulation system for long-term effective delivery. 61
31955776 2020
15
Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome. 61
31493040 2020
16
Therapeutic Enteral Formulas in Children. 61
32038034 2020
17
The cryo-EM Structure of Thermotoga maritima β-Galactosidase: Quaternary Structure Guides Protein Engineering. 61
31874027 2020
18
Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants. 61
31802224 2019
19
Prospective Study of Lactose Intolerance as a Potential Cause of Gas Bloat Syndrome in Patients Treated Surgically for Gastroesophageal Reflux. 61
31854238 2019
20
Lactose intolerance. 61
31663896 2019
21
The Importance of Lactose in the Human Diet: Outcomes of a Mexican Consensus Meeting. 61
31718111 2019
22
A multi-pumping flow analysis system for β-galactosidase activity assays. 61
31126458 2019
23
Diagnostic Utility of Carbohydrate Breath Tests for SIBO, Fructose, and Lactose Intolerance. 61
31617133 2019
24
Milk Analog: Plant based alternatives to conventional milk, production, potential and health concerns. 61
31617734 2019
25
Rediscovering acidophilus milk, its quality characteristics, manufacturing methods, flavor chemistry and nutritional value. 61
31617740 2019
26
Clinical Approach to Lactose Intolerance. 61
31556907 2019
27
Oligosaccharides act as the high efficiency stabilizer for β-galactosidase under heat treatment. 61
31260766 2019
28
Carboxymethylpachymaran entrapped plant-based hollow microcapsules for delivery and stabilization of β-galactosidase. 61
31313784 2019
29
Lower Gastrointestinal Conditions: Malabsorption Syndromes. 61
31411845 2019
30
The barriers and enablers to achieving adequate calcium intake in young adults: a qualitative study using focus groups. 61
30941809 2019
31
Association of Lactase Persistence Genotypes (rs4988235) and Ethnicity with Dairy Intake in a Healthy U.S. Population. 61
31405126 2019
32
Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. 61
31175813 2019
33
Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome. 61
29912753 2019
34
Physico-chemical properties of Khoa prepared from lactose hydrolyzed buffalo milk. 61
31205361 2019
35
Effects of Agitation Speed and Kinetic Studies on Probiotication of Pomegranate Juice with Lactobacillus casei. 61
31247970 2019
36
Congruency of Genetic Predisposition to Lactase Persistence and Lactose Breath Test. 61
31226742 2019
37
An Examination of Medically Necessary Diets within the Framework of the Thrifty Food Plan. 61
30939945 2019
38
Epidemiology of Cow's Milk Allergy. 61
31083388 2019
39
Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls: A meta-analysis. 61
30560578 2019
40
Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy. 61
31137035 2019
41
Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. 61
31010241 2019
42
Real-time PCR based detection of the lactase non-persistence associated genetic variant LCT-13910C>T directly from whole blood. 61
30790118 2019
43
[Birth-cohort analysis in adult-type hypolactasia]. 61
30931598 2019
44
Cow's Milk Consumption and Health: A Health Professional's Guide. 61
30247998 2019
45
13910C>T and 22018G>A LCT gene polymorphisms in diagnosing hypolactasia in children. 61
31080605 2019
46
Lactose Intolerance and Bone Health: The Challenge of Ensuring Adequate Calcium Intake. 61
30925689 2019
47
The First Report about the Laparoscopic Sleeve Gastrectomy-Induced Lactose Intolerance. 61
30627988 2019
48
Switch from tablet levothyroxine to oral solution resolved reduced absorption by intestinal parasitosis. 61
30897550 2019
49
Lactose intolerance: what is a correct management? 61
30892454 2019
50
Assessment of lactase activity in humans by measurement of galactitol and galactonate in serum and urine after milk intake. 61
30721917 2019

Variations for Lactose Intolerance

ClinVar genetic disease variations for Lactose Intolerance:

6 (show top 50) (show all 61) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 LCT NM_002299.4(LCT):c.4347T>C (p.Phe1449=)SNV Conflicting interpretations of pathogenicity 331175 rs17699796 2:136562454-136562454 2:135804884-135804884
2 LCT NM_002299.4(LCT):c.4173+6_4173+8delshort repeat Conflicting interpretations of pathogenicity 331178 rs375300532 2:136564690-136564692 2:135807120-135807122
3 LCT NM_002299.4(LCT):c.2763G>A (p.Ala921=)SNV Conflicting interpretations of pathogenicity 331193 rs116951780 2:136567154-136567154 2:135809584-135809584
4 LCT NM_002299.4(LCT):c.4576C>T (p.Leu1526=)SNV Conflicting interpretations of pathogenicity 331173 rs140074771 2:136561587-136561587 2:135804017-135804017
5 LCT NM_002299.4(LCT):c.4026G>A (p.Thr1342=)SNV Conflicting interpretations of pathogenicity 331180 rs150640616 2:136564845-136564845 2:135807275-135807275
6 LCT NM_002299.4(LCT):c.2760C>T (p.Gly920=)SNV Conflicting interpretations of pathogenicity 331194 rs200579267 2:136567157-136567157 2:135809587-135809587
7 LCT NM_002299.4(LCT):c.2457C>T (p.His819=)SNV Uncertain significance 331196 rs149425549 2:136567460-136567460 2:135809890-135809890
8 LCT NM_002299.4(LCT):c.1396G>T (p.Gly466Trp)SNV Uncertain significance 331203 rs377102890 2:136575222-136575222 2:135817652-135817652
9 LCT NM_002299.4(LCT):c.4122C>T (p.Tyr1374=)SNV Uncertain significance 331179 rs557321611 2:136564749-136564749 2:135807179-135807179
10 LCT NM_002299.4(LCT):c.319G>A (p.Glu107Lys)SNV Uncertain significance 331212 rs761296720 2:136594421-136594421 2:135836851-135836851
11 LCT NM_002299.4(LCT):c.*251G>ASNV Uncertain significance 331157 rs886054860 2:136545643-136545643 2:135788073-135788073
12 LCT NM_002299.4(LCT):c.*10A>CSNV Uncertain significance 331160 rs200994158 2:136545884-136545884 2:135788314-135788314
13 LCT NM_002299.4(LCT):c.5771T>C (p.Val1924Ala)SNV Uncertain significance 331161 rs886054861 2:136545907-136545907 2:135788337-135788337
14 LCT NM_002299.4(LCT):c.5656G>A (p.Val1886Ile)SNV Uncertain significance 331163 rs376732886 2:136546022-136546022 2:135788452-135788452
15 LCT NM_002299.4(LCT):c.5493C>T (p.Tyr1831=)SNV Uncertain significance 331166 rs369410973 2:136547211-136547211 2:135789641-135789641
16 LCT NM_002299.4(LCT):c.4239A>G (p.Pro1413=)SNV Uncertain significance 331177 rs752925060 2:136562562-136562562 2:135804992-135804992
17 LCT NM_002299.4(LCT):c.3986C>T (p.Thr1329Met)SNV Uncertain significance 331181 rs555708380 2:136564885-136564885 2:135807315-135807315
18 LCT NM_002299.4(LCT):c.3595G>A (p.Ala1199Thr)SNV Uncertain significance 331185 rs886054863 2:136566322-136566322 2:135808752-135808752
19 LCT NM_002299.4(LCT):c.3532C>T (p.Leu1178=)SNV Uncertain significance 331186 rs886054864 2:136566385-136566385 2:135808815-135808815
20 LCT NM_002299.4(LCT):c.3390G>A (p.Glu1130=)SNV Uncertain significance 331187 rs886054865 2:136566527-136566527 2:135808957-135808957
21 LCT NM_002299.4(LCT):c.54G>C (p.Trp18Cys)SNV Uncertain significance 331214 rs886054870 2:136594686-136594686 2:135837116-135837116
22 LCT NM_002299.4(LCT):c.3759G>A (p.Thr1253=)SNV Uncertain significance 331183 rs764860323 2:136566158-136566158 2:135808588-135808588
23 LCT NM_002299.4(LCT):c.3599C>T (p.Thr1200Met)SNV Uncertain significance 331184 rs148317168 2:136566318-136566318 2:135808748-135808748
24 LCT NM_002299.4(LCT):c.3341A>G (p.Gln1114Arg)SNV Uncertain significance 331188 rs148838160 2:136566576-136566576 2:135809006-135809006
25 LCT NM_002299.4(LCT):c.1780C>G (p.Gln594Glu)SNV Uncertain significance 331199 rs886054867 2:136570454-136570454 2:135812884-135812884
26 LCT NM_002299.4(LCT):c.2177G>A (p.Arg726His)SNV Uncertain significance 331197 rs886054866 2:136570057-136570057 2:135812487-135812487
27 LCT NM_002299.4(LCT):c.1902C>T (p.Pro634=)SNV Uncertain significance 331198 rs202014246 2:136570332-136570332 2:135812762-135812762
28 LCT NM_002299.4(LCT):c.4646A>G (p.Tyr1549Cys)SNV Uncertain significance 331171 rs147495948 2:136561517-136561517 2:135803947-135803947
29 LCT NM_002299.4(LCT):c.4434T>C (p.Asp1478=)SNV Uncertain significance 331174 rs778761405 2:136562367-136562367 2:135804797-135804797
30 LCT NM_002299.4(LCT):c.3848C>T (p.Thr1283Met)SNV Uncertain significance 331182 rs147755711 2:136566069-136566069 2:135808499-135808499
31 LCT NM_002299.4(LCT):c.1045G>A (p.Glu349Lys)SNV Uncertain significance 331205 rs886054868 2:136575573-136575573 2:135818003-135818003
32 LCT NM_002299.4(LCT):c.621C>T (p.His207=)SNV Uncertain significance 331209 rs369174474 2:136594119-136594119 2:135836549-135836549
33 LCT NM_002299.4(LCT):c.*230T>CSNV Uncertain significance 331158 rs749324196 2:136545664-136545664 2:135788094-135788094
34 LCT NM_002299.4(LCT):c.1461G>A (p.Ala487=)SNV Uncertain significance 331201 rs146206234 2:136575157-136575157 2:135817587-135817587
35 LCT NM_002299.4(LCT):c.4695C>T (p.Tyr1565=)SNV Uncertain significance 331170 rs886054862 2:136558348-136558348 2:135800778-135800778
36 LCT NM_002299.4(LCT):c.643G>A (p.Gly215Arg)SNV Uncertain significance 331208 rs886054869 2:136590758-136590758 2:135833188-135833188
37 LCT NM_002299.4(LCT):c.*325G>CSNV Uncertain significance 331156 rs62170085 2:136545569-136545569 2:135787999-135787999
38 LCT NM_002299.4(LCT):c.3286G>A (p.Ala1096Thr)SNV Uncertain significance 331189 rs146467199 2:136566631-136566631 2:135809061-135809061
39 LCT NM_002299.4(LCT):c.3285C>T (p.His1095=)SNV Uncertain significance 331190 rs372534937 2:136566632-136566632 2:135809062-135809062
40 LCT NM_002299.4(LCT):c.3006G>A (p.Arg1002=)SNV Uncertain significance 331191 rs114815229 2:136566911-136566911 2:135809341-135809341
41 LCT NM_002299.4(LCT):c.2883C>T (p.Ala961=)SNV Uncertain significance 331192 rs140994860 2:136567034-136567034 2:135809464-135809464
42 LCT NM_002299.4(LCT):c.5529C>T (p.Pro1843=)SNV Uncertain significance 331165 rs761696901 2:136547175-136547175 2:135789605-135789605
43 LCT NM_002299.4(LCT):c.4922T>C (p.Val1641Ala)SNV Uncertain significance 331167 rs557029000 2:136555653-136555653 2:135798083-135798083
44 LCT NM_002299.4(LCT):c.4777G>A (p.Val1593Met)SNV Likely benign 331169 rs35891837 2:136558266-136558266 2:135800696-135800696
45 LCT NM_002299.4(LCT):c.*442_*443GT[1]short repeat Likely benign 331154 rs140433552 2:136545449-136545450 2:135787879-135787880
46 LCT NM_002299.4(LCT):c.1650C>G (p.Gly550=)SNV Likely benign 331200 rs35093754 2:136574968-136574968 2:135817398-135817398
47 LCT NM_002299.4(LCT):c.318C>T (p.Asp106=)SNV Likely benign 331213 rs34307240 2:136594422-136594422 2:135836852-135836852
48 LCT NM_002299.4(LCT):c.*429A>CSNV Likely benign 331155 rs77631953 2:136545465-136545465 2:135787895-135787895
49 LCT NM_002299.4(LCT):c.729C>G (p.Val243=)SNV Likely benign 331206 rs3816088 2:136587238-136587238 2:135829668-135829668
50 LCT NM_002299.4(LCT):c.454G>A (p.Ala152Thr)SNV Benign/Likely benign 331211 rs114525655 2:136594286-136594286 2:135836716-135836716

Expression for Lactose Intolerance

Search GEO for disease gene expression data for Lactose Intolerance.

Pathways for Lactose Intolerance

GO Terms for Lactose Intolerance

Cellular components related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.5 VDR TOR1A TGM2 SLC24A5 PTH ATP4A
2 extracellular space GO:0005615 9.28 PTH INS GLB1 CSN2 CSN1S1 CRP

Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.56 TREH SI LCT GLB1
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.4 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 9.37 ATP4A ATP12A
5 negative regulation of blood vessel diameter GO:0097756 9.32 INS CRP
6 polysaccharide digestion GO:0044245 9.16 SI LCT
7 carbohydrate metabolic process GO:0005975 9.02 SLC2A5 SI LCT INS GLB1
8 negative regulation of protein oligomerization GO:0032460 8.96 INS ALB

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 TREH SI LCT GLB1

Sources for Lactose Intolerance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
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68 SNOMED-CT via HPO
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