Lactose Intolerance

Categories: Gastrointestinal diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Lactose Intolerance

MalaCards integrated aliases for Lactose Intolerance:

Name: Lactose Intolerance 12 25 55 6 43 44 15 63 40 17 72 33
Lm - Lactose Malabsorption 12
Dairy Product Intolerance 25
Milk Sugar Intolerance 25
Lactose Malabsorption 25
Hypolactasia 25
Alactasia 25


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Disease Ontology 12 DOID:10604
MeSH 44 D007787
NCIt 50 C3154
ICD10 33 E73 E73.9
UMLS 72 C0022951

Summaries for Lactose Intolerance

Genetics Home Reference : 25 Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine. Congenital lactase deficiency, also called congenital alactasia, is a disorder in which infants are unable to break down lactose in breast milk or formula. This form of lactose intolerance results in severe diarrhea. If affected infants are not given a lactose-free infant formula, they may develop severe dehydration and weight loss. Lactose intolerance in adulthood is caused by reduced production of lactase after infancy (lactase nonpersistence). If individuals with lactose intolerance consume lactose-containing dairy products, they may experience abdominal pain, bloating, flatulence, nausea, and diarrhea beginning 30 minutes to 2 hours later. Most people with lactase nonpersistence retain some lactase activity and can include varying amounts of lactose in their diets without experiencing symptoms. Often, affected individuals have difficulty digesting fresh milk but can eat certain dairy products such as cheese or yogurt without discomfort. These foods are made using fermentation processes that break down much of the lactose in milk.

MalaCards based summary : Lactose Intolerance, also known as lm - lactose malabsorption, is related to lactose intolerance, adult type and diarrhea, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Galactose metabolism. The drugs Guaifenesin and Methadone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and small intestine, and related phenotype is Decreased Dengue Infection.

MedlinePlus : 43 Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

PubMed Health : 63 About lactose intolerance: Stomach ache, bloating, "gas" and diarrhea are all typical digestive symptoms that some people have after eating or drinking dairy products. People who have difficulty digesting dairy products may only tolerate small amounts of lactose (a sugar found in milk and other dairy products). This is called lactose intolerance. But some people who are sensitive to milk might actually have a different problem. It is important to get the diagnosis right before deciding to make major changes to your diet, especially in children, teenagers and people who need more calcium. Lactose intolerance is not an allergy. This is an important difference. People who have a true milk allergy can react to even a tiny amount of dairy foods or milk. But people who are lactose intolerant can sometimes consume quite a lot of these products without having any major problems.

Wikipedia : 75 Lactose intolerance is a condition in which people have symptoms due to the decreased ability to digest... more...

Related Diseases for Lactose Intolerance

Diseases in the Lactose Intolerance family:

Lactose Intolerance, Adult Type

Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 lactose intolerance, adult type 34.0 MCM6 LCT
2 diarrhea 32.2 SI LCT
3 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 12.6
4 lactase deficiency, congenital 12.0
5 congenital short bowel syndrome 11.4
6 osmotic diarrhea 11.4
7 short bowel syndrome 11.4
8 streptococcal group a invasive disease 11.4
9 irritable bowel syndrome 10.7
10 celiac disease 1 10.5
11 osteoporosis 10.5
12 overgrowth syndrome 10.5
13 bone mineral density quantitative trait locus 8 10.5
14 bone mineral density quantitative trait locus 15 10.5
15 gastroenteritis 10.5
16 constipation 10.4
17 milk allergy 10.4
18 ulcerative colitis 10.4
19 inflammatory bowel disease 10.3
20 giardiasis 10.3
21 dyspepsia 10.3
22 intestinal disease 10.3
23 colitis 10.2
24 protein-energy malnutrition 10.2
25 hypothyroidism 10.2
26 food allergy 10.2
27 cataract 10.2
28 crohn's disease 10.2
29 crohn's colitis 10.2
30 systemic lupus erythematosus 10.2
31 pituitary hormone deficiency, combined, 2 10.2
32 lupus erythematosus 10.2
33 pulmonary alveolar microlithiasis 10.2
34 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
35 hepatic coma 10.2
36 hepatic encephalopathy 10.2
37 mental depression 10.2
38 bilirubin metabolic disorder 10.2
39 encephalopathy 10.2
40 ovarian cancer 10.1
41 acrodermatitis enteropathica, zinc-deficiency type 10.1
42 body mass index quantitative trait locus 1 10.1
43 acute diarrhea 10.1
44 autosomal recessive disease 10.1
45 metabolic acidosis 10.1
46 immunoglobulin alpha deficiency 10.1
47 osteomalacia 10.1
48 dysentery 10.1
49 kwashiorkor 10.1
50 acrodermatitis 10.1

Graphical network of the top 20 diseases related to Lactose Intolerance:

Diseases related to Lactose Intolerance

Symptoms & Phenotypes for Lactose Intolerance

UMLS symptoms related to Lactose Intolerance:

nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Dengue Infection GR00348-A-1 8.62 ATP6AP1 DOCK4

Drugs & Therapeutics for Lactose Intolerance

Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Methadone Approved, Illicit Phase 4 76-99-3 4095
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5 Narcotics Phase 4
6 Opiate Alkaloids Phase 4
7 Respiratory System Agents Phase 4
8 Analgesics, Opioid Phase 4
9 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
10 Antitussive Agents Phase 4
11 Bifidobacterium Phase 4
Histamine Approved, Investigational Phase 3 51-45-6 774
Ketotifen Approved Phase 3 34580-13-7, 34580-14-8 3827
14 Acidophilus Phase 3
15 Anti-Allergic Agents Phase 3
16 Histamine Antagonists Phase 3
17 Histamine H1 Antagonists Phase 3
Histamine Phosphate Phase 3 51-74-1 65513
19 Antipruritics Phase 3
20 Dermatologic Agents Phase 3
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
30 Calcium, Dietary Phase 2
31 Nutrients Phase 2
32 insulin Phase 1, Phase 2
33 Insulin, Globin Zinc Phase 1, Phase 2
34 Gastrointestinal Agents Phase 2
35 Hormones Phase 2
36 Bone Density Conservation Agents Phase 2
37 Trace Elements Phase 2
38 Micronutrients Phase 2
39 Vitamin D2 Phase 2
40 Vitamins Phase 2
41 Ergocalciferols Phase 2
42 Calciferol Phase 2
43 Liver Extracts Phase 1, Phase 2
44 Protective Agents Phase 2
45 Antiemetics Phase 2
46 Neuroprotective Agents Phase 2
47 glucocorticoids Phase 2
48 Methylprednisolone Acetate Phase 2
49 Antineoplastic Agents, Hormonal Phase 2
50 Hormone Antagonists Phase 2

Interventional clinical trials:

(show top 50) (show all 77)
# Name Status NCT ID Phase Drugs
1 Evaluation of the Impact of LacTEST on Diagnostic Thinking and on Patient Management, and of the Reproducibility (Test-Retest), for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance Completed NCT02636413 Phase 4 gaxilose
2 Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People Completed NCT02878876 Phase 4
3 Comparative Effects of Milk With A2 Type Beta Casein Versus Milk With A1 and A2 Beta Casein Proteins on Gastrointestinal Physiology, Symptoms and Cognitive Behavior for the Health People Who Are Intolerant to Traditional Cow Milk Completed NCT02406469 Phase 4
4 Evaluation of Efficacy of Methadone Versus Morphine for Treatment of Neonatal Abstinence Syndrome (NAS). Completed NCT01804075 Phase 4 Methadone;Morphine
5 Effects of an Association of the Two Bifidobacteria Probiotics Bifidobacterium Breve B632 and Bifidobacterium Breve BR03 in Intestinal Bacterial Colonization and in the Prevention and/or Reduction of the Incidence of Colics in Infants Completed NCT03219931 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
6 Therapeutic Effects of Mesalamine and Amitriptyline in IBS: a Randomized Clinical Trial Withdrawn NCT02190526 Phase 4 Mesalazine(asacol 800 mg);Amitriptyline;placebo like asacol;placebo like amitriptyline
7 A Phase III, Non-Inferiority, Randomized, Double-Blind, Parallel-Group, Multicentre, Single-Dose, Comparative Clinical Study of Lactase Eurofarma (Test Drug) and Lactaid® (Comparative Drug), Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance (Hypolactasia) Completed NCT01145339 Phase 3 Lactase
8 A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance Completed NCT03597516 Phase 3 RP-G28;Placebos
9 A Phase III, Non-Inferiority, Randomized, Blind, Parallel-Group, Multicentre, Multiple-Dose, Comparative Clinical Study of Lactase Eurofarma and Lactaid®, Assessing the Efficacy and Safety in the Treatment of Patients With Lactose Intolerance" Completed NCT01145586 Phase 3 Lactase Oral Tablets
10 A Phase 2b/3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Two Doses of RP-G28 in Subjects With Lactose Intolerance Completed NCT02673749 Phase 2, Phase 3 RP-G28
11 Decreasing Rates of Illnesses in Kids (DRINK) Completed NCT00356382 Phase 3 Lactobacillus (L.) casei
12 Randomized Controlled Trial of a Reduced Carbohydrate Formulation of F75 Therapeutic Milk Among Children With Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
13 PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2 Recruiting NCT03582176 Phase 3 Lactose Placebo;Ketotifen Fumarate 2mg;Ketotifen Fumarate 5mg
14 Cow's Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula (TeHF2013-01) in Infants With Confirmed Cow's Milk Protein Allergy Unknown status NCT02149134 Phase 2
15 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Effectiveness, Safety and Tolerability of RP-G28 in Subjects With Symptoms Associated With Lactose Intolerance Completed NCT01113619 Phase 2 RP-G28 or placebo;RP-G28 or placebo
16 A Double-Blind, Randomized, Placebo-Controlled Multicenter Study to Assess the Safety and Efficacy of AST-120 in Patients With Non-Constipating Irritable Bowel Syndrome Completed NCT00583128 Phase 2 AST-120;Celphere® CP-305
17 Safe and Effective Vitamin D Supplementation in HIV Completed NCT01092338 Phase 2 Cholecalciferol (Vit D3)
18 Influence of the Consumption of Milk Drink With Bifidobacterium Animalis in Symptoms of Constipation. Completed NCT02091115 Phase 1, Phase 2
19 Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease Completed NCT01016418 Phase 1, Phase 2
20 Efficacy of Combination Therapy of Glucocorticoids, and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis: A Pilot Study. Completed NCT02265328 Phase 2
21 Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of Kefir Terminated NCT02707198 Phase 2 kefir
22 Prospective, Open-Label, Randomized, Two-Period, Two-Sequence, Crossover Study Comparing RP-G28 Administered in the Fasted State and the Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Volunteers Completed NCT03563846 Phase 1 RP-G28
23 Probiotic Ingestion and Isoagglutinin Titers Completed NCT00891787 Phase 1
24 Effect of Whole Milk Intake on the Cardio-metabolic Risk Factors of Healthy Person With or Without Lactose Maldigestion Unknown status NCT02798718
25 Clinical Utility of Carbohydrate Breath Tests in Unexplained GI Symptoms Unknown status NCT03261856
26 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
27 An Audit on Management of Chronic Diarrhea Unknown status NCT03269305
28 Building Better Bones in Children Unknown status NCT00063037
29 64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings Unknown status NCT02231047
30 A Randomised, Controlled, Parallel Study to Determine the Immunomodulatory Effects of Pre- and Probiotics Upon the Immune Response to Influenza Vaccination in Young and Older Volunteers Unknown status NCT01066377
31 The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1 Unknown status NCT02644590 Early Phase 1 Melatonin
32 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
33 A Combination of Yoghurt Bacteria and Acid Lactase From Aspergillus Oryzae Improves Lactose Digestion in Lactose Malabsorbers More Reliably Than Preparations Containing Acid Lactase or Yoghurt Bacteria Alone Completed NCT01593631
34 Understanding Perceived Lactose Intolerance in White, Black, and Hispanic Adults Completed NCT01331265
35 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
36 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People. Completed NCT00395954
37 A Randomized, Controlled, Double-blind, Cross-over, Single-centre Study to Investigate the Effect of a Fermented Infant Formula on Lactose Digestion in Lactose Intolerant Adults Completed NCT02703987
38 Modulation of Lactase Expression by a New Synthetic PPARgamma Ligand in Ex-vivo Cultures of Duodenal Biopsies Completed NCT02902016 GED
39 A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People Who Also Have Ulcerative Colitis Completed NCT00403923
40 β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion: Probiotic and Lactose Intolerance Completed NCT02518295
41 Comparison of Raw Milk Consumption vs. Other Milk Sources on Lactose Digestion in Healthy Individuals With Self-reported Lactose Intolerance Completed NCT01129791
42 Comparison of Two Extensively Hydrolyzed Formulas for the Treatment of Children With Cow's Milk Intolerance Completed NCT01727115
43 Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution: Randomized, Double-blind, Placebo-controlled, Positive-controlled, Three-way Crossover, Acute Lactose Challenge Completed NCT03814668
44 Secondary Lactose Intolerance Due to Chronic Norovirus Infection in Renal Transplant Recipients Completed NCT01840891
45 Prospective Assessment of High Titre TTG to Diagnose Celiac Disease in Select Paediatric Patients. Completed NCT00175760
46 Differential Biologic Impact of Lactose Consumption in Lactase Persistent and Non-persistent Populations: Evaluation of Microflora and Insulin/Glycemic Response Completed NCT00599859
47 The Effects of Rifaximin Therapy in Patients Pre-Diagnosed With Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo Controlled Study Completed NCT02009618 Rifaximin;placebo
48 Calcium Bioavailability of Cassia Leaves in Post-Menopausal Women Completed NCT02291315
49 Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance? Completed NCT01705171
50 Confocal Endomicrosopy for the Detection of Food Intolerance in Patients With Irritable Bowel Syndrome Completed NCT01692613

Search NIH Clinical Center for Lactose Intolerance

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cochrane evidence based reviews: lactose intolerance

Genetic Tests for Lactose Intolerance

Anatomical Context for Lactose Intolerance

MalaCards organs/tissues related to Lactose Intolerance:

Testes, Bone, Small Intestine, Colon, Breast, Kidney, Liver

Publications for Lactose Intolerance

Articles related to Lactose Intolerance:

(show top 50) (show all 1301)
# Title Authors PMID Year
Lactose Intolerance and Bone Health: The Challenge of Ensuring Adequate Calcium Intake. 38 17
30925689 2019
Lactose intolerance: what is a correct management? 38 17
30892454 2019
Lactose-Free Dairy Products: Market Developments, Production, Nutrition and Health Benefits. 17
30841534 2019
Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population. 9 38
18980667 2008
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. 9 38
17651714 2007
Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? 9 38
17574225 2007
Hypolactasia as a molecular basis of lactose intolerance. 9 38
17133732 2006
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase. 9 38
17190185 2006
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. 9 38
16301215 2005
The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. 9 38
12795467 2003
Identification of a variant associated with adult-type hypolactasia. 9 38
11788828 2002
Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. 9 38
11332711 2001
Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes. 9 38
1976654 1990
A multi-pumping flow analysis system for β-galactosidase activity assays. 38
31126458 2019
Carboxymethylpachymaran entrapped plant-based hollow microcapsules for delivery and stabilization of β-galactosidase. 38
31313784 2019
Lower Gastrointestinal Conditions: Malabsorption Syndromes. 38
31411845 2019
Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. 38
31175813 2019
Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. 38
31427404 2019
The barriers and enablers to achieving adequate calcium intake in young adults: a qualitative study using focus groups. 38
30941809 2019
Association of Lactase Persistence Genotypes (rs4988235) and Ethnicity with Dairy Intake in a Healthy U.S. Population. 38
31405126 2019
Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome. 38
29912753 2019
Genetic and Oral Tests for the Diagnosis of Lactose Intolerance in Mixed-Ancestry Brazilians with Metabolic Syndrome. 38
31352438 2019
Congruency of Genetic Predisposition to Lactase Persistence and Lactose Breath Test. 38
31226742 2019
Physico-chemical properties of Khoa prepared from lactose hydrolyzed buffalo milk. 38
31205361 2019
Effects of Agitation Speed and Kinetic Studies on Probiotication of Pomegranate Juice with Lactobacillus casei. 38
31247970 2019
Oligosaccharides act as the high efficiency stabilizer for β-galactosidase under heat treatment. 38
31260766 2019
Nutrition Knowledge of Elderly and Middle-age Urban Population and Its Effects on Diet Quality and Dairy Consumption: A Cross-sectional Study in Eight Cities of China (P10-060-19). 38
31225005 2019
An Examination of Medically Necessary Diets within the Framework of the Thrifty Food Plan. 38
30939945 2019
Epidemiology of Cow's Milk Allergy. 38
31083388 2019
Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls: A meta-analysis. 38
30560578 2019
Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy. 38
31137035 2019
Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. 38
31010241 2019
Real-time PCR based detection of the lactase non-persistence associated genetic variant LCT-13910C>T directly from whole blood. 38
30790118 2019
[Birth-cohort analysis in adult-type hypolactasia]. 38
30931598 2019
Cow's Milk Consumption and Health: A Health Professional's Guide. 38
30247998 2019
13910C>T and 22018G>A LCT gene polymorphisms in diagnosing hypolactasia in children. 38
31080605 2019
The First Report about the Laparoscopic Sleeve Gastrectomy-Induced Lactose Intolerance. 38
30627988 2019
Switch from tablet levothyroxine to oral solution resolved reduced absorption by intestinal parasitosis. 38
30897550 2019
Assessment of lactase activity in humans by measurement of galactitol and galactonate in serum and urine after milk intake. 38
30721917 2019
Inhibition of Maillard Reactions by Replacing Galactose with Galacto-Oligosaccharides in Casein Model Systems. 38
30582810 2019
Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells. 38
30448289 2019
Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. 38
28738753 2019
Physical health in children with neurodevelopmental disorders. 38
30043349 2019
[Carbohydrate-related nutritional and genetic risks of obesity for indigenous northerners]. 38
30811129 2019
The effects of probiotics in lactose intolerance: A systematic review. 38
29425071 2019
Diet and the Role of Food in Common Gastrointestinal Diseases. 38
30466667 2019
Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms-a Pilot Study. 38
30617948 2019
Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia. 38
30619942 2018
Digestive side-effects with teriflunomide: Thoughts on lactose. 38
30409479 2018
Gender, Age, Race and Lactose Intolerance: Is There Evidence to Support a Differential Symptom Response? A Scoping Review. 38
30544891 2018

Variations for Lactose Intolerance

ClinVar genetic disease variations for Lactose Intolerance:

6 (show top 50) (show all 61)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 LCT NM_002299.4(LCT): c.4347T> C (p.Phe1449=) single nucleotide variant Uncertain significance rs17699796 2:136562454-136562454 2:135804884-135804884
2 LCT NM_002299.3(LCT): c.4173+6_4173+8delGAG deletion Uncertain significance rs375300532 2:136564690-136564692 2:135807120-135807122
3 LCT NM_002299.4(LCT): c.3286G> A (p.Ala1096Thr) single nucleotide variant Uncertain significance rs146467199 2:136566631-136566631 2:135809061-135809061
4 LCT NM_002299.4(LCT): c.3285C> T (p.His1095=) single nucleotide variant Uncertain significance rs372534937 2:136566632-136566632 2:135809062-135809062
5 LCT NM_002299.4(LCT): c.3006G> A (p.Arg1002=) single nucleotide variant Uncertain significance rs114815229 2:136566911-136566911 2:135809341-135809341
6 LCT NM_002299.4(LCT): c.2883C> T (p.Ala961=) single nucleotide variant Uncertain significance rs140994860 2:136567034-136567034 2:135809464-135809464
7 LCT NM_002299.4(LCT): c.2763G> A (p.Ala921=) single nucleotide variant Uncertain significance rs116951780 2:136567154-136567154 2:135809584-135809584
8 LCT NM_002299.4(LCT): c.1461G> A (p.Ala487=) single nucleotide variant Uncertain significance rs146206234 2:136575157-136575157 2:135817587-135817587
9 LCT NM_002299.4(LCT): c.5529C> T (p.Pro1843=) single nucleotide variant Uncertain significance rs761696901 2:136547175-136547175 2:135789605-135789605
10 LCT NM_002299.4(LCT): c.4922T> C (p.Val1641Ala) single nucleotide variant Uncertain significance rs557029000 2:136555653-136555653 2:135798083-135798083
11 LCT NM_002299.4(LCT): c.4695C> T (p.Tyr1565=) single nucleotide variant Uncertain significance rs886054862 2:136558348-136558348 2:135800778-135800778
12 LCT NM_002299.4(LCT): c.643G> A (p.Gly215Arg) single nucleotide variant Uncertain significance rs886054869 2:136590758-136590758 2:135833188-135833188
13 LCT NM_002299.4(LCT): c.4576C> T (p.Leu1526=) single nucleotide variant Uncertain significance rs140074771 2:136561587-136561587 2:135804017-135804017
14 LCT NM_002299.4(LCT): c.4434T> C (p.Asp1478=) single nucleotide variant Uncertain significance rs778761405 2:136562367-136562367 2:135804797-135804797
15 LCT NM_002299.4(LCT): c.3848C> T (p.Thr1283Met) single nucleotide variant Uncertain significance rs147755711 2:136566069-136566069 2:135808499-135808499
16 LCT NM_002299.4(LCT): c.*325G> C single nucleotide variant Uncertain significance rs62170085 2:136545569-136545569 2:135787999-135787999
17 LCT NM_002299.4(LCT): c.2177G> A (p.Arg726His) single nucleotide variant Uncertain significance rs886054866 2:136570057-136570057 2:135812487-135812487
18 LCT NM_002299.4(LCT): c.1902C> T (p.Pro634=) single nucleotide variant Uncertain significance rs202014246 2:136570332-136570332 2:135812762-135812762
19 LCT NM_002299.4(LCT): c.4122C> T (p.Tyr1374=) single nucleotide variant Uncertain significance rs557321611 2:136564749-136564749 2:135807179-135807179
20 LCT NM_002299.4(LCT): c.4026G> A (p.Thr1342=) single nucleotide variant Uncertain significance rs150640616 2:136564845-136564845 2:135807275-135807275
21 LCT NM_002299.4(LCT): c.3759G> A (p.Thr1253=) single nucleotide variant Uncertain significance rs764860323 2:136566158-136566158 2:135808588-135808588
22 LCT NM_002299.4(LCT): c.3599C> T (p.Thr1200Met) single nucleotide variant Uncertain significance rs148317168 2:136566318-136566318 2:135808748-135808748
23 LCT NM_002299.4(LCT): c.3341A> G (p.Gln1114Arg) single nucleotide variant Uncertain significance rs148838160 2:136566576-136566576 2:135809006-135809006
24 LCT NM_002299.4(LCT): c.1780C> G (p.Gln594Glu) single nucleotide variant Uncertain significance rs886054867 2:136570454-136570454 2:135812884-135812884
25 LCT NM_002299.4(LCT): c.1045G> A (p.Glu349Lys) single nucleotide variant Uncertain significance rs886054868 2:136575573-136575573 2:135818003-135818003
26 LCT NM_002299.4(LCT): c.621C> T (p.His207=) single nucleotide variant Uncertain significance rs369174474 2:136594119-136594119 2:135836549-135836549
27 LCT NM_002299.4(LCT): c.*230T> C single nucleotide variant Uncertain significance rs749324196 2:136545664-136545664 2:135788094-135788094
28 LCT NM_002299.4(LCT): c.4646A> G (p.Tyr1549Cys) single nucleotide variant Uncertain significance rs147495948 2:136561517-136561517 2:135803947-135803947
29 LCT NM_002299.4(LCT): c.*251G> A single nucleotide variant Uncertain significance rs886054860 2:136545643-136545643 2:135788073-135788073
30 LCT NM_002299.4(LCT): c.*10A> C single nucleotide variant Uncertain significance rs200994158 2:136545884-136545884 2:135788314-135788314
31 LCT NM_002299.4(LCT): c.5771T> C (p.Val1924Ala) single nucleotide variant Uncertain significance rs886054861 2:136545907-136545907 2:135788337-135788337
32 LCT NM_002299.4(LCT): c.5656G> A (p.Val1886Ile) single nucleotide variant Uncertain significance rs376732886 2:136546022-136546022 2:135788452-135788452
33 LCT NM_002299.4(LCT): c.5493C> T (p.Tyr1831=) single nucleotide variant Uncertain significance rs369410973 2:136547211-136547211 2:135789641-135789641
34 LCT NM_002299.4(LCT): c.4239A> G (p.Pro1413=) single nucleotide variant Uncertain significance rs752925060 2:136562562-136562562 2:135804992-135804992
35 LCT NM_002299.4(LCT): c.3986C> T (p.Thr1329Met) single nucleotide variant Uncertain significance rs555708380 2:136564885-136564885 2:135807315-135807315
36 LCT NM_002299.4(LCT): c.3595G> A (p.Ala1199Thr) single nucleotide variant Uncertain significance rs886054863 2:136566322-136566322 2:135808752-135808752
37 LCT NM_002299.4(LCT): c.3532C> T (p.Leu1178=) single nucleotide variant Uncertain significance rs886054864 2:136566385-136566385 2:135808815-135808815
38 LCT NM_002299.4(LCT): c.3390G> A (p.Glu1130=) single nucleotide variant Uncertain significance rs886054865 2:136566527-136566527 2:135808957-135808957
39 LCT NM_002299.4(LCT): c.2760C> T (p.Gly920=) single nucleotide variant Uncertain significance rs200579267 2:136567157-136567157 2:135809587-135809587
40 LCT NM_002299.4(LCT): c.2457C> T (p.His819=) single nucleotide variant Uncertain significance rs149425549 2:136567460-136567460 2:135809890-135809890
41 LCT NM_002299.4(LCT): c.1396G> T (p.Gly466Trp) single nucleotide variant Uncertain significance rs377102890 2:136575222-136575222 2:135817652-135817652
42 LCT NM_002299.4(LCT): c.319G> A (p.Glu107Lys) single nucleotide variant Uncertain significance rs761296720 2:136594421-136594421 2:135836851-135836851
43 LCT NM_002299.4(LCT): c.54G> C (p.Trp18Cys) single nucleotide variant Uncertain significance rs886054870 2:136594686-136594686 2:135837116-135837116
44 LCT NM_002299.4(LCT): c.318C> T (p.Asp106=) single nucleotide variant Likely benign rs34307240 2:136594422-136594422 2:135836852-135836852
45 LCT NM_002299.4(LCT): c.729C> G (p.Val243=) single nucleotide variant Likely benign rs3816088 2:136587238-136587238 2:135829668-135829668
46 LCT NM_002299.4(LCT): c.*429A> C single nucleotide variant Likely benign rs77631953 2:136545465-136545465 2:135787895-135787895
47 LCT NM_002299.4(LCT): c.454G> A (p.Ala152Thr) single nucleotide variant Likely benign rs114525655 2:136594286-136594286 2:135836716-135836716
48 LCT NM_002299.4(LCT): c.1650C> G (p.Gly550=) single nucleotide variant Likely benign rs35093754 2:136574968-136574968 2:135817398-135817398
49 LCT NM_002299.4(LCT): c.5768C> A (p.Pro1923Gln) single nucleotide variant Likely benign rs114828879 2:136545910-136545910 2:135788340-135788340
50 LCT NM_002299.4(LCT): c.2714A> G (p.Asp905Gly) single nucleotide variant Likely benign rs115690016 2:136567203-136567203 2:135809633-135809633

Expression for Lactose Intolerance

Search GEO for disease gene expression data for Lactose Intolerance.

Pathways for Lactose Intolerance

GO Terms for Lactose Intolerance

Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.13 TREH SI LCT
2 polysaccharide digestion GO:0044245 8.62 SI LCT

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 TREH SI MCM6 LCT ANPEP
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.96 SI LCT
3 hydrolase activity, acting on glycosyl bonds GO:0016798 8.8 TREH SI LCT

Sources for Lactose Intolerance

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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