MCID: LGP001
MIFTS: 30

Lagophthalmos

Categories: Eye diseases

Aliases & Classifications for Lagophthalmos

MalaCards integrated aliases for Lagophthalmos:

Name: Lagophthalmos 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12959
ICD9CM 36 374.2 374.20
SNOMED-CT 69 60735000
ICD10 34 H02.2 H02.20
UMLS 74 C0152226

Summaries for Lagophthalmos

MalaCards based summary : Lagophthalmos is related to paralytic lagophthalmos and cicatricial lagophthalmos. An important gene associated with Lagophthalmos is CFDP1 (Craniofacial Development Protein 1). The drugs Iron and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, breast and skin.

Wikipedia : 77 Lagophthalmos is the inability to close the eyelids... more...

Related Diseases for Lagophthalmos

Diseases related to Lagophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 paralytic lagophthalmos 12.3
2 cicatricial lagophthalmos 12.3
3 mechanical lagophthalmos 12.1
4 blepharocheilodontic syndrome 1 11.5
5 frontofacionasal dysplasia 11.1
6 facial paresis, hereditary congenital, 3 11.1
7 facial paralysis 10.5
8 keratopathy 10.4
9 leprosy 3 10.4
10 hansen's disease 10.4
11 ptosis 10.4
12 ectropion 10.3
13 exophthalmos 10.1
14 breast cancer 9.9
15 inclusion body myositis 9.9
16 myositis 9.9
17 urofacial syndrome 1 9.9
18 astigmatism 9.9
19 anorexia nervosa 9.9
20 cutaneous leishmaniasis 9.9
21 congenital ptosis 9.9
22 lepromatous leprosy 9.9
23 enophthalmos 9.9
24 entropion 9.9
25 cicatricial ectropion 9.9
26 keratoconjunctivitis sicca 9.9
27 neuromuscular disease 9.9
28 conjunctivitis 9.9
29 leishmaniasis 9.9
30 keratoconjunctivitis 9.9

Graphical network of the top 20 diseases related to Lagophthalmos:



Diseases related to Lagophthalmos

Symptoms & Phenotypes for Lagophthalmos

Drugs & Therapeutics for Lagophthalmos

Drugs for Lagophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925
2
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
3 Sodium Channel Blockers Not Applicable
4 Anesthetics Not Applicable
5 Peripheral Nervous System Agents Not Applicable
6 Anti-Arrhythmia Agents Not Applicable
7 Central Nervous System Depressants Not Applicable
8 Anesthetics, Local Not Applicable
9 Diuretics, Potassium Sparing Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 External Lid Loading for the Temporary Treatment of the Paresis of the M. Orbicularis Oculi: a Clinical Note Completed NCT01274689
2 Magnetic Correction of Eye Lid Paralysis Completed NCT02988856 Not Applicable
3 Reconstruction of Upper Eyelid With a Newly Modified Cutler-Beard Technique With Tarsoconjunctival Graf Completed NCT03712995 Not Applicable
4 A Real-Time Magnetic Device Prototype for Temporary Management of Paralytic Lagophthalmos Recruiting NCT03848260 Not Applicable
5 NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy Recruiting NCT03239418 Not Applicable
6 Subconjunctival Injection of Local Anesthetic in Anterior Blepharoptosis Repair Recruiting NCT02959697 Not Applicable Subcut. + Subconj. Xylocaine;Subcut. + Sham Subconj. Injection
7 Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE Recruiting NCT03479853
8 Tegaderm and Visual Evoked Potentials Terminated NCT02105337

Search NIH Clinical Center for Lagophthalmos

Genetic Tests for Lagophthalmos

Anatomical Context for Lagophthalmos

MalaCards organs/tissues related to Lagophthalmos:

42
Eye, Breast, Skin, Testes, Thyroid

Publications for Lagophthalmos

Articles related to Lagophthalmos:

(show top 50) (show all 184)
# Title Authors Year
1
Transitioning from a gold weight to an "enhanced" palpebral spring in the management of paralytic lagophthalmos secondary to facial nerve palsy. ( 30047813 )
2019
2
Intraoperative lagophthalmos formula for levator resection in congenital ptosis. ( 30049800 )
2018
3
Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Versus Standard of Care for Postsurgical Lagophthalmos and Exposure Keratopathy: Trends in Visual Outcomes. ( 30289823 )
2018
4
Lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to orbital roof: A case report. ( 29577100 )
2018
5
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 29788690 )
2018
6
Septal chondromucosal grafts in paralytic lagophthalmos. ( 30007536 )
2018
7
Upper-eyelid weight implants for patients with lagophthalmos-comparison of rigid and flexible implants. ( 30100381 )
2018
8
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 30466243 )
2018
9
Response to Letter: Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 30466244 )
2018
10
Lagophthalmos and Ptosis in Inclusion Body Myositis. ( 26784549 )
2017
11
Innovations in Treatment of Lagophthalmos and Exposure Keratopathy. ( 28885249 )
2017
12
Application of Palpebral Spring in Asian Patients With Paralytic Lagophthalmos. ( 27564389 )
2017
13
Photographic technique for the quantitative assessment of lagophthalmos and eyelid position in patients with facial palsy. ( 28233566 )
2017
14
Simultaneous Surgical Treatment for Smile Dysfunction and Lagophthalmos Involving a Dual Latissimus Dorsi Flap. ( 28831334 )
2017
15
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. ( 27541938 )
2016
16
Anterior lamellar recession, blepharoplasty, and supratarsal fixation for cicatricial upper eyelid entropion without lagophthalmos. ( 26869158 )
2016
17
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. ( 26952126 )
2016
18
Temporalis Muscle Transfer for the Treatment of Lagophthalmos in Patients With Leprosy: Refinement in Surgical Techniques to Prevent Postoperative Ptosis. ( 26674897 )
2016
19
Temporary Medial Upper Eyelid Lagophthalmos after External Dacryocystorhinostomy. ( 27116494 )
2016
20
Postseptal Weight Placement for Paralytic Lagophthalmos. ( 27408667 )
2016
21
Efficacy of Steroid and Physiotherapy in Early Reported Lagophthalmos of Patient Affected with Leprosy. A Report from Trbal Dominated Leprosy Endemic State of India. ( 29762951 )
2016
22
Spontaneous Blinking Kinetics on Paralytic Lagophthalmos After Lid Load with Gold Weight or Autogenous Temporalis Fascia Sling. ( 26016510 )
2016
23
Effectiveness of the lower eyelid suspension using fascia lata graft for the treatment of lagophthalmos due to facial paralysis. ( 25821819 )
2015
24
Recession and Extirpation of the Lower Eyelid Retractors for Paralytic Lagophthalmos. ( 26020720 )
2015
25
Placement of an eyelid weight as an upper lid spacer for lagophthalmos. ( 26043940 )
2015
26
Palmaris longus tendon assisted temporalis muscle transfer for lagophthalmos. ( 26139815 )
2015
27
Post-external dacryocystorhinostomy lagophthalmos. ( 24906865 )
2015
28
Bell's sign with lagophthalmos in leprosy. ( 25114280 )
2015
29
Treatment of the periocular complex in paralytic lagophthalmos. ( 25480756 )
2015
30
Bupivacaine Injection for Management of Lagophthalmos Due to Long-Standing Idiopathic Facial Nerve Palsy. ( 25675168 )
2015
31
Lagophthalmos and frozen globe as the initial presentation of invasive breast carcinoma. ( 25861670 )
2015
32
Nocturnal lagophthalmos in children with urofacial syndrome (Ochoa): a novel sign. ( 24248520 )
2014
33
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 24374701 )
2014
34
Reply: Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 24374702 )
2014
35
Use of hyaluronic acid gel in the treatment of lagophthalmos in sunken superior sulcus syndrome. ( 24614548 )
2014
36
Modified silicone sling assisted temporalis muscle transfer in the management of lagophthalmos. ( 24618488 )
2014
37
Nocturnal lagophthalmos: never seen before in hypernatraemic dehydration. ( 24728900 )
2014
38
Augmentation of lateral tarsorrhaphy in lagophthalmos. ( 24786615 )
2014
39
Slow eye movements in idiopathic familial nocturnal lagophthalmos. ( 25156751 )
2014
40
Lagophthalmos after facial palsy: current therapeutic options. ( 25342248 )
2014
41
[Dynamics of lagophthalmos depending on facial nerve repair and its intraoperative monitoring in neurosurgical patients]. ( 25406811 )
2014
42
Upper eyelid platinum chain placement for treating paralytic lagophthalmos. ( 25458343 )
2014
43
Lagophthalmos after v2 maxillary nerve block. ( 25611645 )
2014
44
PROSE treatment for lagophthalmos and exposure keratopathy. ( 23034688 )
2013
45
A red eye on the intensive care unit. Exposure keratopathy with corneal abrasion secondary to lagophthalmos due to chemosis. ( 23723116 )
2013
46
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 23714789 )
2013
47
Alternative surgical treatment of paralytic lagophthalmos using autogenic cartilage grafts and canthopexy. ( 23728241 )
2013
48
Topical rebamipide improves the ocular surface in mild lagophthalmos. ( 23836962 )
2013
49
A device for the functional improvement of lagophthalmos. ( 23851837 )
2013
50
Hyaluronic acid gel weight: a nonsurgical option for the management of paralytic lagophthalmos. ( 24122715 )
2013

Variations for Lagophthalmos

Expression for Lagophthalmos

Search GEO for disease gene expression data for Lagophthalmos.

Pathways for Lagophthalmos

GO Terms for Lagophthalmos

Biological processes related to Lagophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.96 CYP4V2 WDR36
2 oxidation-reduction process GO:0055114 8.8 CYP4V2 DCXR STAB2

Sources for Lagophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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