MCID: LGP001
MIFTS: 34

Lagophthalmos

Categories: Eye diseases, Skin diseases
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Aliases & Classifications for Lagophthalmos

Summaries for Lagophthalmos

MalaCards based summary: Lagophthalmos, also known as defective lid closure, is related to keratopathy and exposure keratitis. An important gene associated with Lagophthalmos is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and 14-3-3 and Regulation of BAD Activity. The drugs Racepinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and thyroid, and related phenotype is behavior/neurological.

Wikipedia: 75 Lagophthalmos is the inability to close the eyelids... more...

Related Diseases for Lagophthalmos

Diseases related to Lagophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 keratopathy 31.1 TAC1 NGF KRT12
2 exposure keratitis 30.9 TSHR MRPL15
3 keratitis, hereditary 30.8 TNF NGF KRT12
4 graves ophthalmopathy 30.4 TSHR TNF
5 corneal ulcer 30.3 TNF TAC1 NGF
6 recurrent corneal erosion 30.1 TAC1 NGF KRT12
7 spastic entropion 30.1 TAC1 NGF
8 xerophthalmia 29.9 TNF BPIFA2
9 tuberculoid leprosy 29.8 TNF CCDC122
10 corneal disease 29.7 TNF TAC1 NGF KRT12
11 keratoconjunctivitis sicca 29.6 TNF NGF BPIFA2
12 dry eye syndrome 29.6 TNF TAC1 NGF BPIFA2
13 urofacial syndrome 1 29.5 TSHZ3 LRIG2 HPSE2
14 paralytic lagophthalmos 11.4
15 cicatricial lagophthalmos 11.3
16 mechanical lagophthalmos 11.2
17 euryblepharon 11.0
18 frontofacionasal dysplasia 11.0
19 facial paresis, hereditary congenital, 3 11.0
20 bell's palsy 10.8
21 facial paralysis 10.7
22 leprosy 3 10.5
23 ptosis 10.5
24 ectropion 10.5
25 papillon-lefevre syndrome 10.5
26 intellectual developmental disorder, autosomal dominant 1 10.3
27 femoral cancer 10.2 TAC1 NGF
28 myofascial pain syndrome 10.2 TAC1 NGF
29 causalgia 10.2 TAC1 NGF
30 detrusor sphincter dyssynergia 10.2 TAC1 NGF
31 acute salpingo-oophoritis 10.2 TAC1 NGF
32 corpus callosum, agenesis of, with abnormal genitalia 10.2 LRIG2 HPSE2
33 punctate epithelial keratoconjunctivitis 10.2 TAC1 NGF
34 neuroma 10.2
35 reflex sympathetic dystrophy 10.2 TAC1 NGF
36 chronic cystitis 10.2 TAC1 NGF
37 diabetic autonomic neuropathy 10.2 TAC1 NGF
38 trigeminal nerve disease 10.2 TAC1 NGF
39 chronic orbital inflammation 10.2 TSHR TNF
40 nerve compression syndrome 10.2 TAC1 NGF
41 diabetic polyneuropathy 10.2 TAC1 NGF
42 astigmatism 10.2
43 intellectual developmental disorder, autosomal dominant 2 10.2
44 congenital ptosis 10.2
45 cartilage disease 10.2
46 entropion 10.2
47 acoustic neuroma 10.2
48 excessive tearing 10.2
49 anterior scleritis 10.1 TNF KRT12
50 diabetic encephalopathy 10.1 TNF NGF

Graphical network of the top 20 diseases related to Lagophthalmos:



Diseases related to Lagophthalmos

Symptoms & Phenotypes for Lagophthalmos

MGI Mouse Phenotypes related to Lagophthalmos:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.36 BPIFA2 CCDC122 HPSE2 LRIG2 NGF POLR3A

Drugs & Therapeutics for Lagophthalmos

Drugs for Lagophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
2
Lidocaine Approved, Vet_approved 137-58-6 3676
3
Iron Approved 7439-89-6 29936
4 Epinephryl borate
5 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Novel Treatment Using Neuromuscular Electrical Stimulation to Improve Eyelid Function in Patients With CN III and CN VII Palsy. Unknown status NCT03239418
2 Evaluation of Intraoperative Lagophthalmos Formula for Levator Resection in Congenital Ptosis on Egyptian Patients Completed NCT04291625
3 The Effectiveness, Safety, and Tolerability of the Nictavi Tarsus Patch in Managing Lagophthalmos in Children and Adolescents Completed NCT05183282
4 Modified Tarsorrhaphy vs Gold Weight Implant Technique for Paralytic Lagophthalmos Treatment in Leprosy Patients: a Randomized Clinical Trial Completed NCT04944498
5 Non-surgical Correction of Eye Lid Paralysis With External Magnet Systems Completed NCT02988856
6 A Real-Time Magnetic Device Prototype for Management of Paralytic Lagophthalmos Suspended NCT03848260
7 A Pilot Study: Does Tegaderm Placement on Eyes to Prevent Lagophthalmos Affect Visual Evoked Potentials Data Latency and Amplitude Terminated NCT02105337

Search NIH Clinical Center for Lagophthalmos

Genetic Tests for Lagophthalmos

Anatomical Context for Lagophthalmos

Organs/tissues related to Lagophthalmos:

MalaCards : Eye, Skin, Thyroid, Bone Marrow, Breast, Bone, Brain

Publications for Lagophthalmos

Articles related to Lagophthalmos:

(show top 50) (show all 1042)
# Title Authors PMID Year
1
Long term ophthalmic complications of distal arthrogryposis type 5D. 62
36459431 2022
2
Autologous fat grafting for the correction of cicatricial ectropion. 62
36270948 2022
3
[Incidence and risk factors of exposure keratopathy in intensive care units: About 91 patients]. 62
36319529 2022
4
Efficacy of Autologous Serum Gel in Neurotrophic Persistent Corneal Epithelial Defects Combined with Lagophthalmos. 62
36152214 2022
5
Hughes flap in the management of lower lid retraction. 62
34949152 2022
6
Upper eyelid reconstruction using an advancement tarso-conjunctival flap. 62
35673716 2022
7
Total Full-Thickness Upper Eyelid Reconstruction: Combination of Mustardé Eyelid Switch Flap with a Bipedicled Periosteal and Tenzel Flap Technique. 62
36008056 2022
8
Facial nerve palsy: Narrative review on the importance of the eye and its assessment. 62
35894515 2022
9
Facial palsy as a manifestation of COVID-19: A systematic review of cases. 62
36320650 2022
10
Modified levator muscle complex suspension on treating pediatric blepharoptosis with poor Bell's phenomenon. 62
35622218 2022
11
Keratopathy in Noonan Syndrome. 62
35867656 2022
12
Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice. 62
35988880 2022
13
A Case of Giant Cell Arteritis that Presented with Buccal Skin Ulceration along the Facial Artery. 62
36198595 2022
14
The burden of physical disability among patients with newly detected leprosy in Yunnan, China, 1990-2020: A population-based, cross-sectional survey. 62
36219605 2022
15
Lagophthalmos after rhinoplasty- a possible complication. 62
36100539 2022
16
Improved Iatrogenic Facial Nerve Paralysis Based on House-Brackmann Facial Nerve Grading System by Using Acupuncture Therapy: A Case Report. 62
36311887 2022
17
Hinged tarsal flap: A novel technique for canthal tendon reconstruction. 62
36062596 2022
18
An eye on the Shih Tzu dog: Ophthalmic examination findings and ocular surface diagnostics. 62
36057776 2022
19
Eyelid Blink Lagophthalmos and Blinking Velocity Changes After External Transcutaneous Dacrocystorhinostomy: A Prospective Study. 62
36084687 2022
20
Blink Reflex in Neurotrophic Keratopathy: An Electrophysiological Evaluation. 62
35170564 2022
21
A review of surgical management of progressive myogenic ptosis. 62
36178005 2022
22
Lagophthalmos: An etiological lookout to frame the decision for management. 62
35918976 2022
23
Upper eyelid weighting for lagophthalmos results in contralateral upper eyelid elevation. 62
34229537 2022
24
Lower Eyelid Sling for Primary and Revision Correction of Paralytic Lagophthalmos. 62
35969387 2022
25
Upper Eyelid Retraction in Graves' Ophthalmopathy: Our Surgical Experience on 153 Cases of Full-Thickness Anterior Blepharotomy with Mullerectomy. 62
35129648 2022
26
A Modified Palpebral Marginal Incision Technique Using Levator Aponeurotic Flap in Blepharoplasty. 62
35676832 2022
27
[The prevention and therapy of corneal ulcers in patients with large-area thermal burns]. 62
35959603 2022
28
Scleral contact lenses for optimal visual recovery in a case of severe acid burn with total lagophthalmos. 62
35790322 2022
29
Features of ophthalmic, magnetic resonance imaging, and histopathology of a feline case of idiopathic sclerosing orbital pseudotumor. 62
35506154 2022
30
Commentary on: Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. 62
35880799 2022
31
Recombinant Human Nerve Growth Factor for Pediatric Neurotrophic Keratopathy. 62
35726907 2022
32
Ocular involvement in facial nerve paralysis: risk factors for severe visual impairment and ocular surface exposure in 1870 patients. 62
35801669 2022
33
A rare cause of acquired esotropia: Leprosy. 62
35791236 2022
34
Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. 62
35788264 2022
35
Clinical Issues-June 2022. 62
35616459 2022
36
Ophthalmic artery occlusion after glabellar hyaluronic acid filler injection. 62
35243152 2022
37
The Prevalence of Ocular Manifestations in the Various Types of Common Skin Disorders at Tertiary Hospital in Ahmedabad, India. 62
35844330 2022
38
Eyelid Reanimation with Free Platysma Graft: Final Stage of Reconstruction after Gunshot Wound to Face. 62
35702359 2022
39
A modified transconjunctival technique for botulinum toxin chemodenervation of levator palpebrae superioris for corneal protection. 62
34117397 2022
40
Anatomy of the lateral orbital wall: A topographic investigation for identification of the lateral canthal attachment. 62
35168924 2022
41
Effects of teprotumumab on patients with long-standing, active thyroid eye disease. 62
35402750 2022
42
The Role of Rigid Suspension and Fixation in Treating Lagophthalmos After Lower Eyelid Reconstruction. 62
34320583 2022
43
Ophthalmic features of craniosynostosis: A Malaysian experience. 62
34219491 2022
44
Medical management and resolution of perinatal bilateral exophthalmia and secondary corneal ulcers in an Antillean manatee (Trichechus manatus manatus) neonate from Puerto Rico. 62
35294800 2022
45
Combined levator and frontalis muscle advancement flaps for recurrent severe congenital ptosis. 62
35469061 2022
46
Contralateral orbicularis oculi muscle transposition in facial paralysis: functional, aesthetic and electromyographic outcomes. A case report and literature update. 62
34157948 2022
47
Conjoint Fascial Sheath Suspension for Correction of Recurrent Blepharoptosis. 62
34462802 2022
48
Surgical removal of orbital tumors by orbital approach using ultrasonic surgical system SONOPET®. 62
33860737 2022
49
The use of the paramedian forehead flap alone or in combination with other techniques in the reconstruction of periocular defects and orbital exenterations. 62
35241795 2022
50
Use of Buried Guide Needle to Fix Inferior Eyelid Orbital Septum Fat for Tear Trough Depression Filling. 62
34519710 2022

Variations for Lagophthalmos

Expression for Lagophthalmos

Search GEO for disease gene expression data for Lagophthalmos.

Pathways for Lagophthalmos

Pathways related to Lagophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 TNF TAC1 NGF
2 10.46 TNF NGF

GO Terms for Lagophthalmos

Sources for Lagophthalmos

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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