MCID: LGP001
MIFTS: 32

Lagophthalmos

Categories: Eye diseases

Aliases & Classifications for Lagophthalmos

MalaCards integrated aliases for Lagophthalmos:

Name: Lagophthalmos 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12959
ICD10 33 H02.2 H02.20
ICD9CM 35 374.2 374.20
SNOMED-CT 68 60735000
UMLS 73 C0152226

Summaries for Lagophthalmos

MalaCards based summary : Lagophthalmos is related to paralytic lagophthalmos and cicatricial lagophthalmos. An important gene associated with Lagophthalmos is DRD5 (Dopamine Receptor D5). The drugs Peripheral Nervous System Agents and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 Lagophthalmos is the inability to close the eyelids... more...

Related Diseases for Lagophthalmos

Graphical network of the top 20 diseases related to Lagophthalmos:



Diseases related to Lagophthalmos

Symptoms & Phenotypes for Lagophthalmos

GenomeRNAi Phenotypes related to Lagophthalmos according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 DRD5
2 Decreased substrate adherent cell growth GR00193-A-2 8.92 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 8.92 DRD5 FGFR2

MGI Mouse Phenotypes related to Lagophthalmos:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 C12orf57 DRD5 FGFR2 HOXA2 LRIG2 WDR36

Drugs & Therapeutics for Lagophthalmos

Drugs for Lagophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Peripheral Nervous System Agents Not Applicable
2 Central Nervous System Depressants Not Applicable
3 Anesthetics Not Applicable
4 Anesthetics, Local Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 External Lid Loading for the Temporary Treatment of the Paresis of the M. Orbicularis Oculi: a Clinical Note Completed NCT01274689
2 Reconstruction of Upper Eyelid With a Newly Modified Cutler-Beard Technique With Tarsoconjunctival Graf Completed NCT03712995 Not Applicable
3 NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy Recruiting NCT03239418 Not Applicable
4 Subconjunctival Injection of Local Anesthetic in Anterior Blepharoptosis Repair Recruiting NCT02959697 Not Applicable Subcut. + Subconj. Xylocaine;Subcut. + Sham Subconj. Injection
5 Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE Recruiting NCT03479853
6 Magnetic Correction of Eye Lid Paralysis Active, not recruiting NCT02988856 Not Applicable
7 Tegaderm and Visual Evoked Potentials Terminated NCT02105337

Search NIH Clinical Center for Lagophthalmos

Genetic Tests for Lagophthalmos

Anatomical Context for Lagophthalmos

MalaCards organs/tissues related to Lagophthalmos:

41
Eye, Skin, Testes, Thyroid

Publications for Lagophthalmos

Articles related to Lagophthalmos:

(show top 50) (show all 184)
# Title Authors Year
1
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 29788690 )
2018
2
Lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to orbital roof: A case report. ( 29577100 )
2018
3
Intraoperative lagophthalmos formula for levator resection in congenital ptosis. ( 30049800 )
2018
4
Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Versus Standard of Care for Postsurgical Lagophthalmos and Exposure Keratopathy: Trends in Visual Outcomes. ( 30289823 )
2018
5
Septal chondromucosal grafts in paralytic lagophthalmos. ( 30007536 )
2018
6
Transitioning from a gold weight to an "enhanced" palpebral spring in the management of paralytic lagophthalmos secondary to facial nerve palsy. ( 30047813 )
2018
7
Upper-eyelid weight implants for patients with lagophthalmos-comparison of rigid and flexible implants. ( 30100381 )
2018
8
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 30466243 )
2018
9
Response to Letter: Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. ( 30466244 )
2018
10
Simultaneous Surgical Treatment for Smile Dysfunction and Lagophthalmos Involving a Dual Latissimus Dorsi Flap. ( 28831334 )
2017
11
Innovations in Treatment of Lagophthalmos and Exposure Keratopathy. ( 28885249 )
2017
12
Photographic technique for the quantitative assessment of lagophthalmos and eyelid position in patients with facial palsy. ( 28233566 )
2017
13
Temporalis Muscle Transfer for the Treatment of Lagophthalmos in Patients With Leprosy: Refinement in Surgical Techniques to Prevent Postoperative Ptosis. ( 26674897 )
2016
14
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. ( 27541938 )
2016
15
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. ( 26952126 )
2016
16
Temporary Medial Upper Eyelid Lagophthalmos after External Dacryocystorhinostomy. ( 27116494 )
2016
17
Postseptal Weight Placement for Paralytic Lagophthalmos. ( 27408667 )
2016
18
Efficacy of Steroid and Physiotherapy in Early Reported Lagophthalmos of Patient Affected with Leprosy. A Report from Trbal Dominated Leprosy Endemic State of India. ( 29762951 )
2016
19
Application of Palpebral Spring in Asian Patients With Paralytic Lagophthalmos. ( 27564389 )
2016
20
Lagophthalmos and Ptosis in Inclusion Body Myositis. ( 26784549 )
2016
21
Anterior lamellar recession, blepharoplasty, and supratarsal fixation for cicatricial upper eyelid entropion without lagophthalmos. ( 26869158 )
2016
22
Spontaneous Blinking Kinetics on Paralytic Lagophthalmos After Lid Load with Gold Weight or Autogenous Temporalis Fascia Sling. ( 26016510 )
2015
23
Palmaris longus tendon assisted temporalis muscle transfer for lagophthalmos. ( 26139815 )
2015
24
Lagophthalmos and frozen globe as the initial presentation of invasive breast carcinoma. ( 25861670 )
2015
25
Effectiveness of the Lower Eyelid Suspension Using Fascia Lata Graft for the Treatment of Lagophthalmos due to Facial Paralysis. ( 25821819 )
2015
26
Placement of an eyelid weight as an upper lid spacer for lagophthalmos. ( 26043940 )
2015
27
Bupivacaine Injection for Management of Lagophthalmos Due to Long-Standing Idiopathic Facial Nerve Palsy. ( 25675168 )
2015
28
Treatment of the periocular complex in paralytic lagophthalmos. ( 25480756 )
2015
29
Recession and Extirpation of the Lower Eyelid Retractors for Paralytic Lagophthalmos. ( 26020720 )
2015
30
Post-external dacryocystorhinostomy lagophthalmos. ( 24906865 )
2014
31
Bell's sign with lagophthalmos in leprosy. ( 25114280 )
2014
32
Slow eye movements in idiopathic familial nocturnal lagophthalmos. ( 25156751 )
2014
33
Use of hyaluronic acid gel in the treatment of lagophthalmos in sunken superior sulcus syndrome. ( 24614548 )
2014
34
Modified silicone sling assisted temporalis muscle transfer in the management of lagophthalmos. ( 24618488 )
2014
35
Augmentation of lateral tarsorrhaphy in lagophthalmos. ( 24786615 )
2014
36
Lagophthalmos after v2 maxillary nerve block. ( 25611645 )
2014
37
Reply: upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 24374702 )
2014
38
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 24374701 )
2014
39
Upper eyelid platinum chain placement for treating paralytic lagophthalmos. ( 25458343 )
2014
40
Nocturnal lagophthalmos: never seen before in hypernatraemic dehydration. ( 24728900 )
2014
41
Lagophthalmos after facial palsy: current therapeutic options. ( 25342248 )
2014
42
[Dynamics of lagophthalmos depending on facial nerve repair and its intraoperative monitoring in neurosurgical patients]. ( 25406811 )
2014
43
Hyaluronic acid gel weight: A nonsurgical option for the management of paralytic lagophthalmos. ( 24122715 )
2013
44
Nocturnal lagophthalmos in children with urofacial syndrome (Ochoa): A novel sign. ( 24248520 )
2013
45
PROSE treatment for lagophthalmos and exposure keratopathy. ( 23034688 )
2013
46
A device for the functional improvement of lagophthalmos. ( 23851837 )
2013
47
Alternative surgical treatment of paralytic lagophthalmos using autogenic cartilage grafts and canthopexy. ( 23728241 )
2013
48
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. ( 23714789 )
2013
49
A red eye on the intensive care unit. Exposure keratopathy with corneal abrasion secondary to lagophthalmos due to chemosis. ( 23723116 )
2013
50
Topical rebamipide improves the ocular surface in mild lagophthalmos. ( 23836962 )
2013

Variations for Lagophthalmos

Expression for Lagophthalmos

Search GEO for disease gene expression data for Lagophthalmos.

Pathways for Lagophthalmos

GO Terms for Lagophthalmos

Biological processes related to Lagophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.26 DRD5 FGFR2
2 post-embryonic development GO:0009791 9.16 C12orf57 FGFR2
3 cellular response to retinoic acid GO:0071300 8.96 FGFR2 HOXA2
4 cell fate commitment GO:0045165 8.62 FGFR2 HOXA2

Sources for Lagophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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