MCID: LGP001
MIFTS: 30

Lagophthalmos

Categories: Eye diseases, Skin diseases

Aliases & Classifications for Lagophthalmos

MalaCards integrated aliases for Lagophthalmos:

Name: Lagophthalmos 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:12959
ICD9CM 34 374.2
SNOMED-CT 67 193936001
ICD10 32 H02.2
UMLS 70 C0152226

Summaries for Lagophthalmos

MalaCards based summary : Lagophthalmos is related to ptosis and urofacial syndrome 1. An important gene associated with Lagophthalmos is HPSE2 (Heparanase 2 (Inactive)). The drugs Iron and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and skin.

Wikipedia : 73 Lagophthalmos is the inability to close the eyelids... more...

Related Diseases for Lagophthalmos

Diseases related to Lagophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 ptosis 30.0 ZFHX4 STAC3 PHOX2A KIF21A
2 urofacial syndrome 1 30.0 LRIG2 HPSE2
3 keratitis, hereditary 29.9 PHOX2A NGF KIF21A
4 keratoconjunctivitis sicca 29.6 NGF BPIFA2
5 hypertropia 29.5 PHOX2A KIF21A
6 congenital ptosis 29.4 ZFHX4 STAC3 PHOX2A KIF21A
7 paralytic lagophthalmos 11.3
8 cicatricial lagophthalmos 11.2
9 mechanical lagophthalmos 11.1
10 blepharocheilodontic syndrome 1 10.9
11 frontofacionasal dysplasia 10.9
12 facial paresis, hereditary congenital, 3 10.9
13 facial paralysis 10.7
14 keratopathy 10.6
15 leprosy 3 10.5
16 hansen's disease 10.5
17 ectropion 10.5
18 yemenite deaf-blind hypopigmentation syndrome 10.3
19 exposure keratitis 10.3
20 corneal ulcer 10.2
21 autosomal dominant non-syndromic intellectual disability 1 10.2
22 neuroma 10.2
23 astigmatism 10.1
24 entropion 10.1
25 bell's palsy 10.1
26 prune belly syndrome 10.1 LRIG2 HPSE2
27 acoustic neuroma 10.1
28 eye disease 10.1
29 conjunctivitis 10.1
30 lepromatous leprosy 10.0
31 cicatricial ectropion 10.0
32 exophthalmos 10.0
33 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
34 autosomal dominant non-syndromic intellectual disability 2 9.9
35 xerophthalmia 9.9
36 enophthalmos 9.9
37 senile ectropion 9.9
38 endophthalmitis 9.9
39 central corneal ulcer 9.9
40 hypotonia 9.9
41 neurotrophic keratopathy 9.9
42 myotonic cataract 9.9 PHOX2A KIF21A
43 fibrosis of extraocular muscles, congenital, 2 9.9 PHOX2A KIF21A
44 paralytic squint 9.9 PHOX2A KIF21A
45 microphthalmia, isolated 5 9.9 PHOX2A KIF21A
46 horner's syndrome 9.9 ZFHX4 NGF
47 partial third-nerve palsy 9.9 PHOX2A KIF21A
48 duane-radial ray syndrome 9.9 PHOX2A KIF21A
49 neurogenic bladder 9.8 NGF LRIG2 HPSE2
50 exotropia 9.8 PHOX2A KIF21A

Graphical network of the top 20 diseases related to Lagophthalmos:



Diseases related to Lagophthalmos

Symptoms & Phenotypes for Lagophthalmos

Drugs & Therapeutics for Lagophthalmos

Drugs for Lagophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved 7439-89-6 23925 29936
2
Epinephrine Approved, Vet_approved 51-43-4 5816
3
Racepinephrine Approved 329-65-7 838
4
Lidocaine Approved, Vet_approved 137-58-6 3676
5 Anesthetics
6 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Real-Time Magnetic Device Prototype for Management of Paralytic Lagophthalmos Unknown status NCT03848260
2 External Lid Loading for the Temporary Treatment of the Paresis of the M. Orbicularis Oculi: a Clinical Note Completed NCT01274689
3 Evaluation of Intraoperative Lagophthalmos Formula for Levator Resection in Congenital Ptosis on Egyptian Patients Completed NCT04291625
4 A Pilot Study: Does Tegaderm Placement on Eyes to Prevent Lagophthalmos Affect Visual Evoked Potentials Data Latency and Amplitude Terminated NCT02105337

Search NIH Clinical Center for Lagophthalmos

Genetic Tests for Lagophthalmos

Anatomical Context for Lagophthalmos

MalaCards organs/tissues related to Lagophthalmos:

40
Eye, Thyroid, Skin, Bone, Brain, Breast, Bone Marrow

Publications for Lagophthalmos

Articles related to Lagophthalmos:

(show top 50) (show all 941)
# Title Authors PMID Year
1
Lagophthalmos after congenital ptosis surgery: comparison between maximal levator resection and frontalis sling operation. 61
32651544 2021
2
Lagophthalmos as a presenting sign in dermatomyositis with muscle involvement limited to the ocular muscles. 61
33732847 2021
3
Silicone Scaffold Support Using a Bilayer Dermal Regeneration Matrix Template for Correction of Primary or Recurrent Eyelid Retraction. 61
32826828 2021
4
Risk for corneal injury in intensive care unit patients: A cohort study. 61
33676811 2021
5
Improved Eyelid Muscle Tension Balance With Refined Frontalis Muscle Flap Suspension in the Treatment of Severe Ptosis. 61
33782325 2021
6
Corneal Neurotization in the Setting of Facial Paralysis: A Comprehensive Review of Surgical Techniques. 61
33654040 2021
7
Predicting Factors Influencing Visual Function of the Eye in Patients with Unresolved Facial Nerve Palsy after Upper Eyelid Gold Weight Loading. 61
33557102 2021
8
Management of corneal ulceration with a moisture chamber due to temporary lagophthalmos in a brain injury patient: A case report. 61
33644176 2021
9
Primary Reconstruction of Extensive Forehead Defects Using Supraorbital Artery Propeller Perforator Flap. 61
33667346 2021
10
Augmented fascia temporalis sling for paralytic ectropion of the lower lid. 61
33607927 2021
11
Use of an Orbital Septum Flap for Correcting Severe Blepharoptosis. 61
33433668 2021
12
[Anterior stromal micropuncture for the treatment of persistent corneal epithelial graft defects after penetrating keratoplasty]. 61
33610154 2021
13
Lagophthalmos of the medial upper eyelid after Mohs surgery of the medial canthus. 61
33318993 2021
14
An Accurate Upper Lid Blepharoplasty: A Key Component of Facial Rejuvenation. 61
33517576 2021
15
Levator recession and minimal lateral tarsorrhaphy for the management of lagophthalmos and corneal exposure in facial palsy. 61
31601122 2021
16
Treatment of Congenital Ptosis in Infants With Associated Amblyopia Using a Frontalis Muscle Flap Eyelid Reanimation Technique. 61
32467524 2021
17
The Function-Preserving Frontalis Orbicularis Oculi Muscle Flap for the Correction of Severe Blepharoptosis With Poor Levator Function. 61
33400770 2021
18
Current Evidence for Corynebacterium on the Ocular Surface. 61
33513871 2021
19
Urofacial (ochoa) syndrome: A literature review. 61
33558177 2021
20
Metastatic breast cancer presenting as an epithelial defect. 61
32932373 2020
21
Acute And Sub-Acute Reconstruction Of Periorbital Thermal Burns Involving The Anterior Lamella Of The Eyelid With Simultaneous Fullthickness Skin Grafting And Amniotic Membrane Grafting. 61
33708023 2020
22
Acute Reconstruction of Periorbital Trauma Resulting in Eyelid Anterior Lamella Loss With Simultaneous Full-thickness Skin Grafting and Amniotic Membrane Grafting: A Case Report. 61
33331944 2020
23
Reconstruction of Lagophthalmos of Upper Eyelid With a Subcutaneous Pedicled Propeller Flap. 61
33252526 2020
24
Successful correction of ichthyosis-related ectropion by autografts. 61
32543709 2020
25
Combined medical and surgical management for cicatricial ectropion in lamellar ichthyosis: A report of three cases. 61
33120713 2020
26
The anterior layer of the levator aponeurosis in blepharoptosis correction. 61
33358565 2020
27
Tarsal-Fixation With Aponeurotic Flap Linkage in Blepharoplasty: Bridge Technique. 61
32639527 2020
28
Safety and Efficacy of the Under-Corrected Frontalis Sling in Myogenic Ptosis Accompanying Extraocular Muscle Paralysis. 61
33136917 2020
29
Recurrent upper eyelid trachomatous entropion repair: long-term efficacy of a five-step approach. 61
33235346 2020
30
Clinical and histological features and outcomes of upper eyelid colobomas in the Saudi population. 61
31722593 2020
31
Single-triangle versus Fox pentagon frontalis suspension for unilateral severe congenital ptosis correction. 61
33045376 2020
32
Limbal Stem Cell Dysfunction in Ichthyosis Follicularis, Alopecia, and Photophobia Syndrome. 61
32482964 2020
33
Blink detection and magnetic force generation for correction of lagophthalmos, with specific regard to implant compatibility testing. 61
33016160 2020
34
Does lagophthalmos change on lying supine after upper eyelid platinum segment chain loading? 61
32873112 2020
35
Safety and Efficacy of the Under-Corrected Frontalis Sling in Myogenic Ptosis Accompanying Extraocular Muscle Paralysis. 61
32890155 2020
36
A Modified Hughes Flap for Correction of Refractory Cicatricial Lower Lid Retraction With Concomitant Ectropion. 61
32265375 2020
37
Advancements in the repair of large upper eyelid defects: A 10-year review. 61
32990145 2020
38
Hard Palate Mucoperiosteal Transplantation for Defects of the Upper Eyelid: A Pilot Study and Evaluation. 61
32091481 2020
39
Topical insulin for refractory persistent corneal epithelial defects. 61
32951459 2020
40
Anterior chamber angle granuloma: A rare ocular manifestation of histoid lepromatous leprosy. 61
32823469 2020
41
Natural history of inflammatory and non-inflammatory dry eye in thyroid eye disease. 61
32847459 2020
42
Evaluation of intraoperative lagophthalmos formula for levator resection in congenital ptosis in Egyptian patients. 61
32806945 2020
43
Neglected ocular surface care in critical care medicine: An observational study. 61
31488350 2020
44
Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease. 61
32635438 2020
45
Full-thickness total upper eyelid reconstruction with a lid switch flap and a reverse superficial temporal artery flap. 61
32205053 2020
46
Oculoplastic considerations for refractive procedures. 61
32487809 2020
47
Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report. 61
32650848 2020
48
[Ophthalmological care of SARS-CoV-2 positive patients in intensive care units]. 61
32617666 2020
49
Strategies of upper blepharoplasty in aging patients with involutional ptosis. 61
32718105 2020
50
Improved Function of Orbicularis Oculi by Dynamic Transfer of Contralateral Orbicularis Oculi Muscle in Patients with Facial Palsy. 61
33488012 2020

Variations for Lagophthalmos

Expression for Lagophthalmos

Search GEO for disease gene expression data for Lagophthalmos.

Pathways for Lagophthalmos

GO Terms for Lagophthalmos

Biological processes related to Lagophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopaminergic neuron differentiation GO:0071542 8.96 TSHR PHOX2A
2 embryo development GO:0009790 8.62 DLX6 DLX4

Sources for Lagophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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