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MCID: LMB004
MIFTS: 14
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Lambda 5 Deficiency
Categories:
Genetic diseases, Immune diseases
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MalaCards integrated aliases for Lambda 5 Deficiency:Classifications:External Ids:
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Disease Ontology :
12
A B cell deficiency that has material basis in mutations in the IGLL1 gene. Lambda 5 mutations can cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.
MalaCards based summary : Lambda 5 Deficiency is related to mu chain disease and congenital hypogammaglobulinemia. An important gene associated with Lambda 5 Deficiency is IGLL1 (Immunoglobulin Lambda Like Polypeptide 1), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Fc-GammaR Pathway. Affiliated tissues include b cells. |
Diseases related to Lambda 5 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:
Graphical network of the top 20 diseases related to Lambda 5 Deficiency:
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MalaCards organs/tissues related to Lambda 5 Deficiency:40
B Cells
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Genes related to Lambda 5 Deficiency (0 elite genes): - Elite gene
- Cancer Census gene in COSMIC
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Search
GEO
for disease gene expression data for Lambda 5 Deficiency.
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Biological processes related to Lambda 5 Deficiency according to GeneCards Suite gene sharing:
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