Lambda 5 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lambda 5 Deficiency

MalaCards integrated aliases for Lambda 5 Deficiency:

Name: Lambda 5 Deficiency ¹¹ ⁵ ¹⁴

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060024

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Summaries for Lambda 5 Deficiency

Disease Ontology: ¹¹ A B cell deficiency that has material basis in mutations in the IGLL1 gene. Lambda 5 mutations can cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.

MalaCards based summary: Lambda 5 Deficiency is related to mu chain disease and bn2 diffuse large b-cell lymphoma. An important gene associated with Lambda 5 Deficiency is IGLL1 (Immunoglobulin Lambda Like Polypeptide 1), and among its related pathways/superpathways are Disease and GPCR Pathway. Related phenotypes are immune system and neoplasm

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Related Diseases for Lambda 5 Deficiency

Diseases related to Lambda 5 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	mu chain disease	10.1	VPREB1 IGLL1
2	bn2 diffuse large b-cell lymphoma	10.0	CD79B BTK
3	ecthyma	10.0	CD79B BTK
4	bird fancier's lung	10.0	IGLL1 CD79A
5	diffuse large b-cell lymphoma activated b-cell type	10.0	CD79B BTK
6	richter's syndrome	10.0	CD79B BTK
7	cerebral lymphoma	9.9	CD79B CD79A
8	b-cell prolymphocytic leukemia	9.9	CD79B CD79A
9	eye lymphoma	9.9	CD79B CD79A
10	amebiasis	9.9	IGLL1 CD79A
11	plasma protein metabolism disease	9.9	CD79B BTK
12	spleen cancer	9.9	CD79B CD79A
13	primary mediastinal b-cell lymphoma	9.9	CD79B CD79A
14	splenic marginal zone lymphoma	9.9	CD79B CD79A
15	waldenstroem's macroglobulinemia	9.9	CD79B BTK
16	immunoglobulin a deficiency 1	9.9	CD79A BTK
17	macroglobulinemia	9.8	BTK BLNK
18	immunodeficiency with hyper-igm, type 1	9.8	CD79A BTK
19	congenital hypogammaglobulinemia	9.8	IGLL1 BTK BLNK
20	heavy chain disease	9.8	VPREB1 IGLL1 CD79A
21	b cell deficiency	9.8	IGLL1 BTK BLNK
22	mature b-cell neoplasm	9.7	CD79B CD79A
23	mcd diffuse large b-cell lymphoma	9.7	CD79B CD79A BTK
24	diffuse large b-cell lymphoma	9.7	CD79B CD79A BTK
25	testicular lymphoma	9.7	CD79B CD79A BTK
26	chronic lymphocytic leukemia/small lymphocytic lymphoma	9.7	CD79B CD79A BTK
27	lymphoplasmacytic lymphoma	9.7	CD79B CD79A BTK
28	central nervous system hematologic cancer	9.7	CD79B CD79A BTK
29	central nervous system lymphoma	9.7	CD79B CD79A BTK
30	marginal zone b-cell lymphoma	9.7	CD79B CD79A BTK
31	lymphoma, mucosa-associated lymphoid type	9.7	CD79B CD79A BTK
32	mantle cell lymphoma	9.7	CD79B CD79A BTK
33	common variable immunodeficiency	9.6	VPREB1 CD79A BTK
34	plasmacytoma	9.6	CD79B CD79A
35	leukemia, acute lymphoblastic	9.6	VPREB1 BTK BLNK
36	agammaglobulinemia 4, autosomal recessive	9.5	VPREB1 CD79B CD79A BLNK
37	lymphoma, non-hodgkin, familial	9.5	CD79B CD79A BTK
38	agammaglobulinemia, x-linked	9.4	CD79B CD79A BTK BLNK
39	agammaglobulinemia, non-bruton type	9.1	PIK3R1 IGLL1 CD79B CD79A BLNK
40	agammaglobulinemia	8.6	VPREB1 PIK3R1 IGLL1 CD79B CD79A BTK

Graphical network of the top 20 diseases related to Lambda 5 Deficiency:

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Symptoms & Phenotypes for Lambda 5 Deficiency

MGI Mouse Phenotypes related to Lambda 5 Deficiency:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.5	BLNK BTK CD79A CD79B IGLL1 PIK3R1
2	neoplasm	MP:0002006	9.46	BLNK BTK CD79A PIK3R1
3	hematopoietic system	MP:0005397	9.17	BLNK BTK CD79A CD79B IGLL1 PIK3R1

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Drugs & Therapeutics for Lambda 5 Deficiency

Search Clinical Trials, NIH Clinical Center for Lambda 5 Deficiency

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Genetic Tests for Lambda 5 Deficiency

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Anatomical Context for Lambda 5 Deficiency

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Publications for Lambda 5 Deficiency

Articles related to Lambda 5 Deficiency:

#	Title	Authors	PMID	Year
1	Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. ⁵	Platt CD...International Consortium for Immunodeficiencies	32888943	2021
2	Diagnostics of primary immunodeficiency diseases: a sequencing capture approach. ⁵	Moens LN...Nilsson M	25502423	2014
3	Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. ⁵	Minegishi Y...Conley ME	9419212	1998

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Genes for Lambda 5 Deficiency

Genes related to Lambda 5 Deficiency (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IGLL1	Immunoglobulin Lambda Like Polypeptide 1	Protein Coding	407.09	Pathogenic ⁵ DISEASES inferred ¹⁴	9419212
2	VPREB1	V-Set Pre-B Cell Surrogate Light Chain 1	Protein Coding	6.78	DISEASES inferred ¹⁴
3	CD79B	CD79b Molecule	Protein Coding	5.62	DISEASES inferred ¹⁴
4	BLNK	B Cell Linker	Protein Coding	5.6	DISEASES inferred ¹⁴
5	CD79A	CD79a Molecule	Protein Coding	5.33	DISEASES inferred ¹⁴
6	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4.92	DISEASES inferred ¹⁴
7	BTK	Bruton Tyrosine Kinase	Protein Coding	4.62	DISEASES inferred ¹⁴

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Variations for Lambda 5 Deficiency

ClinVar genetic disease variations for Lambda 5 Deficiency:

⁵ (show top 50) (show all 148)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	IGLL1	NM_020070.4(IGLL1):c.64C>T (p.Gln22Ter)	SNV	Pathogenic	14824	rs74315491	GRCh37: 22:23922314-23922314 GRCh38: 22:23580127-23580127
2	IGLL1	NM_020070.4(IGLL1):c.258del (p.Gln88fs)	DEL	Conflicting Interpretations Of Pathogenicity	236015	rs532338576	GRCh37: 22:23917218-23917218 GRCh38: 22:23575031-23575031
3	IGLL1	NM_020070.4(IGLL1):c.334G>A (p.Ala112Thr)	SNV	Conflicting Interpretations Of Pathogenicity	538828	rs149986237	GRCh37: 22:23915761-23915761 GRCh38: 22:23573574-23573574
4	IGLL1	NM_020070.4(IGLL1):c.350C>T (p.Thr117Ile)	SNV	Conflicting Interpretations Of Pathogenicity	791698	rs143780139	GRCh37: 22:23915745-23915745 GRCh38: 22:23573558-23573558
5	IGLL1	NM_020070.4(IGLL1):c.616A>T (p.Thr206Ser)	SNV	Conflicting Interpretations Of Pathogenicity	439824	rs139491925	GRCh37: 22:23915479-23915479 GRCh38: 22:23573292-23573292
6	IGLL1	NM_020070.4(IGLL1):c.437C>T (p.Thr146Met)	SNV	Conflicting Interpretations Of Pathogenicity	547919	rs112775194	GRCh37: 22:23915658-23915658 GRCh38: 22:23573471-23573471
7	IGLL1	NM_020070.4(IGLL1):c.425C>T (p.Pro142Leu)	SNV	Uncertain Significance	14825	rs1064422	GRCh37: 22:23915670-23915670 GRCh38: 22:23573483-23573483
8	IGLL1	NM_020070.4(IGLL1):c.335C>A (p.Ala112Asp)	SNV	Uncertain Significance	1356613		GRCh37: 22:23915760-23915760 GRCh38: 22:23573573-23573573
9	IGLL1	NM_020070.4(IGLL1):c.14C>G (p.Thr5Arg)	SNV	Uncertain Significance	1387818		GRCh37: 22:23922364-23922364 GRCh38: 22:23580177-23580177
10	IGLL1	NM_020070.4(IGLL1):c.134C>T (p.Ser45Leu)	SNV	Uncertain Significance	1391863		GRCh37: 22:23922244-23922244 GRCh38: 22:23580057-23580057
11	IGLL1	NM_020070.4(IGLL1):c.477C>T (p.Gly159=)	SNV	Uncertain Significance	1395050		GRCh37: 22:23915618-23915618 GRCh38: 22:23573431-23573431
12	IGLL1	NM_020070.4(IGLL1):c.545C>T (p.Thr182Met)	SNV	Uncertain Significance	1376930		GRCh37: 22:23915550-23915550 GRCh38: 22:23573363-23573363
13	IGLL1	NM_020070.4(IGLL1):c.241A>G (p.Arg81Gly)	SNV	Uncertain Significance	1376935		GRCh37: 22:23917235-23917235 GRCh38: 22:23575048-23575048
14	IGLL1	NM_020070.4(IGLL1):c.590T>G (p.Met197Arg)	SNV	Uncertain Significance	1363505		GRCh37: 22:23915505-23915505 GRCh38: 22:23573318-23573318
15	IGLL1	NM_020070.4(IGLL1):c.232A>C (p.Thr78Pro)	SNV	Uncertain Significance	1397988		GRCh37: 22:23917244-23917244 GRCh38: 22:23575057-23575057
16	IGLL1	NM_020070.4(IGLL1):c.446G>T (p.Trp149Leu)	SNV	Uncertain Significance	1414307		GRCh37: 22:23915649-23915649 GRCh38: 22:23573462-23573462
17	IGLL1	NM_020070.4(IGLL1):c.323G>A (p.Ser108Asn)	SNV	Uncertain Significance	1426980		GRCh37: 22:23915772-23915772 GRCh38: 22:23573585-23573585
18	IGLL1	NM_020070.4(IGLL1):c.426G>A (p.Pro142=)	SNV	Uncertain Significance	1445521		GRCh37: 22:23915669-23915669 GRCh38: 22:23573482-23573482
19	IGLL1	NM_020070.4(IGLL1):c.367T>C (p.Ser123Pro)	SNV	Uncertain Significance	1435654		GRCh37: 22:23915728-23915728 GRCh38: 22:23573541-23573541
20	IGLL1	NM_020070.4(IGLL1):c.605C>G (p.Thr202Ser)	SNV	Uncertain Significance	1497677		GRCh37: 22:23915490-23915490 GRCh38: 22:23573303-23573303
21	IGLL1	NM_020070.4(IGLL1):c.585G>T (p.Gln195His)	SNV	Uncertain Significance	1504082		GRCh37: 22:23915510-23915510 GRCh38: 22:23573323-23573323
22	IGLL1	NM_020070.4(IGLL1):c.520G>T (p.Ala174Ser)	SNV	Uncertain Significance	1345788		GRCh37: 22:23915575-23915575 GRCh38: 22:23573388-23573388
23	IGLL1	NM_020070.4(IGLL1):c.288T>G (p.His96Gln)	SNV	Uncertain Significance	1348438		GRCh37: 22:23917188-23917188 GRCh38: 22:23575001-23575001
24	IGLL1	NM_020070.4(IGLL1):c.197G>T (p.Arg66Leu)	SNV	Uncertain Significance	836258	rs569884568	GRCh37: 22:23922181-23922181 GRCh38: 22:23579994-23579994
25	IGLL1	NM_020070.4(IGLL1):c.118C>T (p.Arg40Cys)	SNV	Uncertain Significance	840747	rs199529532	GRCh37: 22:23922260-23922260 GRCh38: 22:23580073-23580073
26	IGLL1	NM_020070.4(IGLL1):c.178C>G (p.Arg60Gly)	SNV	Uncertain Significance	847416	rs146108390	GRCh37: 22:23922200-23922200 GRCh38: 22:23580013-23580013
27	IGLL1	NM_020070.4(IGLL1):c.35C>T (p.Ala12Val)	SNV	Uncertain Significance	939503	rs775788164	GRCh37: 22:23922343-23922343 GRCh38: 22:23580156-23580156
28	IGLL1	NM_020070.4(IGLL1):c.619G>A (p.Val207Met)	SNV	Uncertain Significance	947731	rs779159751	GRCh37: 22:23915476-23915476 GRCh38: 22:23573289-23573289
29	IGLL1	NM_020070.4(IGLL1):c.178C>T (p.Arg60Trp)	SNV	Uncertain Significance	965383	rs146108390	GRCh37: 22:23922200-23922200 GRCh38: 22:23580013-23580013
30	IGLL1	NM_020070.4(IGLL1):c.17G>T (p.Gly6Val)	SNV	Uncertain Significance	965546	rs1460659708	GRCh37: 22:23922361-23922361 GRCh38: 22:23580174-23580174
31	IGLL1	NM_020070.4(IGLL1):c.163C>T (p.Pro55Ser)	SNV	Uncertain Significance	1002499	rs759845022	GRCh37: 22:23922215-23922215 GRCh38: 22:23580028-23580028
32	IGLL1	NM_020070.4(IGLL1):c.53C>T (p.Pro18Leu)	SNV	Uncertain Significance	1025838	rs374187217	GRCh37: 22:23922325-23922325 GRCh38: 22:23580138-23580138
33	IGLL1	NM_020070.4(IGLL1):c.606_607del (p.Val203fs)	DEL	Uncertain Significance	1044631	rs765895465	GRCh37: 22:23915488-23915489 GRCh38: 22:23573301-23573302
34	IGLL1	NM_020070.4(IGLL1):c.550G>A (p.Glu184Lys)	SNV	Uncertain Significance	1054982		GRCh37: 22:23915545-23915545 GRCh38: 22:23573358-23573358
35	IGLL1	NM_020070.4(IGLL1):c.617C>T (p.Thr206Met)	SNV	Uncertain Significance	1057687		GRCh37: 22:23915478-23915478 GRCh38: 22:23573291-23573291
36	IGLL1	NM_020070.4(IGLL1):c.338C>A (p.Thr113Asn)	SNV	Uncertain Significance	1063380		GRCh37: 22:23915757-23915757 GRCh38: 22:23573570-23573570
37	IGLL1	NM_020070.4(IGLL1):c.362C>T (p.Pro121Leu)	SNV	Uncertain Significance	569037	rs746843426	GRCh37: 22:23915733-23915733 GRCh38: 22:23573546-23573546
38	IGLL1	NM_020070.4(IGLL1):c.377T>C (p.Leu126Pro)	SNV	Uncertain Significance	569973	rs142959335	GRCh37: 22:23915718-23915718 GRCh38: 22:23573531-23573531
39	IGLL1	NM_020070.4(IGLL1):c.197G>A (p.Arg66Gln)	SNV	Uncertain Significance	572361	rs569884568	GRCh37: 22:23922181-23922181 GRCh38: 22:23579994-23579994
40	IGLL1	NM_020070.4(IGLL1):c.458G>T (p.Gly153Val)	SNV	Uncertain Significance	572836	rs138007109	GRCh37: 22:23915637-23915637 GRCh38: 22:23573450-23573450
41	IGLL1	NM_020070.4(IGLL1):c.606_609delinsTGCA (p.Val203Ala)	INDEL	Uncertain Significance	575852	rs1569069031	GRCh37: 22:23915486-23915489 GRCh38: 22:23573299-23573302
42	IGLL1	NM_020070.4(IGLL1):c.254G>A (p.Arg85Gln)	SNV	Uncertain Significance	575956	rs200178386	GRCh37: 22:23917222-23917222 GRCh38: 22:23575035-23575035
43	IGLL1	NM_020070.4(IGLL1):c.21G>C (p.Gln7His)	SNV	Uncertain Significance	576645	rs1044209410	GRCh37: 22:23922357-23922357 GRCh38: 22:23580170-23580170
44	IGLL1	NM_020070.4(IGLL1):c.478G>A (p.Val160Met)	SNV	Uncertain Significance	644111	rs138799296	GRCh37: 22:23915617-23915617 GRCh38: 22:23573430-23573430
45	IGLL1	NM_020070.4(IGLL1):c.301G>A (p.Gly101Arg)	SNV	Uncertain Significance	644739	rs775909535	GRCh37: 22:23917175-23917175 GRCh38: 22:23574988-23574988
46	IGLL1	NM_020070.4(IGLL1):c.368C>G (p.Ser123Cys)	SNV	Uncertain Significance	661875	rs537809626	GRCh37: 22:23915727-23915727 GRCh38: 22:23573540-23573540
47	IGLL1	NM_020070.4(IGLL1):c.460A>T (p.Thr154Ser)	SNV	Uncertain Significance	664104	rs1602287119	GRCh37: 22:23915635-23915635 GRCh38: 22:23573448-23573448
48	IGLL1	NM_020070.4(IGLL1):c.527G>A (p.Ser176Asn)	SNV	Uncertain Significance	664919	rs765426613	GRCh37: 22:23915568-23915568 GRCh38: 22:23573381-23573381
49	IGLL1	NM_020070.4(IGLL1):c.607G>A (p.Val203Met)	SNV	Uncertain Significance	538827	rs771552908	GRCh37: 22:23915488-23915488 GRCh38: 22:23573301-23573301
50	IGLL1	NC_000022.10:g.(?_23917134)_(23922397_?)dup	DUP	Uncertain Significance	583726		GRCh37: 22:23917134-23922397 GRCh38: 22:23574947-23580210

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Expression for Lambda 5 Deficiency

Search GEO for disease gene expression data for Lambda 5 Deficiency.

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Pathways for Lambda 5 Deficiency

Pathways related to Lambda 5 Deficiency according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.4	PIK3R1 CD79B CD79A BTK BLNK
2	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.29	PIK3R1 CD79B CD79A BTK BLNK
3	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing: Ubiquitination and Proteasome degradation ⁶⁶ Neddylation ⁶⁶	13.14	PIK3R1 CD79B CD79A BTK BLNK
4	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.08	PIK3R1 CD79B CD79A BTK BLNK
5	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	12.94	PIK3R1 CD79B CD79A BTK
6	SARS-CoV-2 Infection ⁶⁶ Show member pathways SARS-CoV Infections ⁶⁶ SARS-CoV-2 activates/modulates innate and adaptive immune responses ⁶⁶ SARS-CoV-2-host interactions ⁶⁶	12.87	CD79B CD79A BTK BLNK
7	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.73	PIK3R1 CD79B CD79A BTK BLNK
8	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.52	BTK CD79A CD79B PIK3R1
9	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.28	PIK3R1 CD79B CD79A BTK BLNK
10	NF-kappaB Signaling ³	12.23	BLNK BTK CD79A
11	Immune response Fc epsilon RI pathway ²² Show member pathways Fc-epsilon receptor I signaling in mast cells ⁶¹ Immune response BCR pathway ²²	11.99	PIK3R1 CD79B CD79A BTK BLNK
12	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	11.89	VPREB1 PIK3R1 IGLL1
13	Fc-GammaR Pathway ⁶⁴ Show member pathways Fc-Gamma-RIIB Signaling in B-Cells ⁶⁴	11.67	PIK3R1 CD79B CD79A BTK BLNK
14	Potential therapeutics for SARS ⁶⁶	11.66	CD79B CD79A BTK BLNK
15	Signaling by Erythropoietin ⁶⁶ Show member pathways EPO signaling pathway ⁶¹ Erythropoietin activates Phosphoinositide-3-kinase (PI3K) ⁶⁶ Erythropoietin activates Phospholipase C gamma (PLCG) ⁶⁶ Erythropoietin activates RAS ⁶⁶ Erythropoietin activates STAT5 ⁶⁶	11.57	PIK3R1 BTK
16	DAP12 interactions ⁶⁶ Show member pathways DAP12 signaling ⁶⁶	11.46	PIK3R1 BTK
17	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.43	CD79A BLNK
18	BCR signaling pathway ⁶¹	11.17	PIK3R1 CD79B CD79A BTK BLNK
19	Class I PI3K signaling events ⁶¹	11.04	PIK3R1 BTK BLNK
20	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶	10.61	PIK3R1 CD79B CD79A BTK BLNK

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GO Terms for Lambda 5 Deficiency

Cellular components related to Lambda 5 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	B cell receptor complex	GO:0019815	8.92	CD79B CD79A

Biological processes related to Lambda 5 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.86	VPREB1 PIK3R1 IGLL1 CD79B
2	B cell differentiation	GO:0030183	9.56	PIK3R1 CD79B CD79A BLNK
3	B cell activation	GO:0042113	9.55	CD79A BTK BLNK
4	B cell receptor signaling pathway	GO:0050853	9.32	IGLL1 CD79B CD79A BTK BLNK

Molecular functions related to Lambda 5 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phospholipase binding	GO:0043274	9.26	BTK BLNK
2	transmembrane receptor protein tyrosine kinase adaptor activity	GO:0005068	8.92	PIK3R1 BLNK

Sources

Sources for Lambda 5 Deficiency

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LMB004 MIFTS: 27	Lambda 5 Deficiency Categories: Genetic diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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