MCID: LMB009
MIFTS: 15

Lambdoid Synostosis

Categories: Rare diseases

Aliases & Classifications for Lambdoid Synostosis

MalaCards integrated aliases for Lambdoid Synostosis:

Name: Lambdoid Synostosis 52
Synostotic Posterior Plagiocephaly 71
Craniosynostosis, Lambdoidal 52

Classifications:



External Ids:

UMLS 71 C1833340

Summaries for Lambdoid Synostosis

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 3267 Definition Familial lambdoid synostosis is a rare, genetic cranial malformation characterized by unilateral or bilateral synostosis of the lambdoid suture in multiple members of a single family. Unilateral cases typically present ipsilateral occipitomastoid bulge, compensatory contralateral parietal and frontal bossing, displacement of one ear, lateral deviation of jaw and compensatory deformation of cervical spine while bilateral cases usually manifest with flat and widened occiput, displacement of both ears and frequent occurrence of raised intracranial pressure. Visit the Orphanet disease page for more resources.

MalaCards based summary : Lambdoid Synostosis, also known as synostotic posterior plagiocephaly, is related to craniosynostosis 4 and synostosis. An important gene associated with Lambdoid Synostosis is MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2). Affiliated tissues include brain and bone.

Related Diseases for Lambdoid Synostosis

Diseases related to Lambdoid Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 craniosynostosis 4 11.8
2 synostosis 11.0
3 craniosynostosis 10.8
4 plagiocephaly 10.8
5 isolated plagiocephaly 10.4
6 torticollis 10.2
7 sudden infant death syndrome 10.2
8 scoliosis 10.2
9 hydrocephalus 10.2
10 connective tissue disease 10.2
11 humeroradioulnar synostosis 10.2
12 syndromic craniosynostosis 10.2

Graphical network of the top 20 diseases related to Lambdoid Synostosis:



Diseases related to Lambdoid Synostosis

Symptoms & Phenotypes for Lambdoid Synostosis

Drugs & Therapeutics for Lambdoid Synostosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MRI for Non-invasive Evaluation of Brain Stress Completed NCT01898650

Search NIH Clinical Center for Lambdoid Synostosis

Genetic Tests for Lambdoid Synostosis

Anatomical Context for Lambdoid Synostosis

MalaCards organs/tissues related to Lambdoid Synostosis:

40
Brain, Bone

Publications for Lambdoid Synostosis

Articles related to Lambdoid Synostosis:

(show top 50) (show all 95)
# Title Authors PMID Year
1
Comparative analysis of cranial vault remodeling versus endoscopic suturectomy in the treatment of unilateral lambdoid craniosynostosis. 61
32302983 2020
2
Three-Dimensional Volumetric Changes in Posterior Vault Distraction With Distraction Osteogenesis. 61
32282486 2020
3
Comparison of Black Bone MRI and 3D-CT in the preoperative evaluation of patients with craniosynostosis. 61
31917189 2020
4
Isolated Lambdoid Craniosynostosis. 61
31633668 2019
5
Can Head Circumference Be Used as a Proxy for Intracranial Volume in Patients With Craniosynostosis? 61
30973835 2019
6
Short- and Long-Term Outcomes by Procedure Type for Nonsagittal Single-Suture Craniosynostosis. 61
30640851 2019
7
Classification of Subtypes of Apert Syndrome, Based on the Type of Vault Suture Synostosis. 61
31044122 2019
8
A systematic review of endoscopic versus open treatment of craniosynostosis. Part 2: the nonsagittal single sutures. 61
29979132 2018
9
Novel 1q22-q23.1 duplication in a patient with lambdoid and metopic craniosynostosis, muscular hypotonia, and psychomotor retardation. 61
29845577 2018
10
The Role of Preoperative Imaging in the Management of Nonsyndromic Lambdoid Craniosynostosis. 61
29040146 2018
11
Treatment of Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. 61
28059851 2017
12
Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. 61
27751966 2016
13
Biallelic mutations in CYP26B1: A differential diagnosis for Pfeiffer and Antley-Bixler syndromes. 61
27410456 2016
14
Surgical correction of lambdoid synostosis - New technique and first results. 61
27595190 2016
15
Neosuture formation after endoscope-assisted craniosynostosis repair. 61
27128960 2016
16
Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis. 61
27035551 2016
17
Physiological Changes and Clinical Implications of Syndromic Craniosynostosis. 61
27226850 2016
18
[DEMOGRAPHIC AND ANATOMIC CHARACTERISTICS AND SURGERY RESULTS IN CHILDREN WHO WERE TREATED IN SOROKA FOR CRANIOSYNOSTOSIS]. 61
27526554 2016
19
Lambdoid Craniosynostosis: The Relationship with Chiari Deformations and an Analysis of Surgical Outcomes. 61
26910678 2016
20
Oculo-auriculo-vertebral spectrum with craniosynostosis and osteo-cartilagineous multiple defects: a diffuse chondro-membranous-osteo-dysplasia. 61
26714781 2015
21
Diagnostic features of prematurely fused cranial sutures on plain skull X-rays. 61
26298825 2015
22
Lambdoid Synostosis Versus Positional Posterior Plagiocephaly, a Comparison of Skull Base and Shape of Calvarium Using Computed Tomography Imaging. 61
26335322 2015
23
Maternofetal Trauma in Craniosynostosis. 61
26218396 2015
24
Cranial Base and Posterior Cranial Vault Asymmetry After Open and Endoscopic Repair of Isolated Lambdoid Craniosynostosis. 61
26114505 2015
25
Intellectual and academic functioning of school-age children with single-suture craniosynostosis. 61
25713274 2015
26
Occipital plagiocephaly: unilateral lambdoid synostosis versus positional plagiocephaly. 61
25275089 2015
27
Craniosynostosis of the lambdoid suture. 61
25210507 2014
28
Surgical correction for unilateral lambdoid synostosis: a systematic review. 61
24978452 2014
29
Clinical and imaging findings in children with non-syndromic lambdoid synostosis. 61
24162514 2014
30
Suitable indication for the application of distraction osteogenesis: occipital enlargement for lambdoid synostosis. 61
24036720 2013
31
Laypersons' ratings of appearance in children with and without single-suture craniosynostosis. 61
23851801 2013
32
Benign radiographic coronal synostosis after sagittal synostosis repair. 61
23714915 2013
33
Does conventional posterior vault remodeling alter endocranial morphology in patients with true lambdoid synostosis? 61
23348266 2013
34
Chiari malformation in nonsyndromal single craniosynostosis--much ado about nothing? 61
22790904 2012
35
Craniosynostosis: posterior two-third cranial vault reconstruction using bioresorbable plates and a PDS suture lattice in sagittal and lambdoid synostosis. 61
22872255 2012
36
Posterior plagiocephaly. 61
22872253 2012
37
Chiari malformation associated with craniosynostosis. 61
21882907 2011
38
Lambdoid synostosis and craniofacial dysmorphism with normal intellect: A novel syndrome? 61
21204239 2011
39
The variable position of the ear in lambdoid synostosis. 61
20948412 2011
40
Analysis of differences in the cranial base and facial skeleton of patients with lambdoid synostosis and deformational plagiocephaly. 61
20871483 2011
41
The earliest evidence of true lambdoid craniosynostosis: the case of "Benjamina", a Homo heidelbergensis child. 61
20361331 2010
42
Forward position of the ear in a patient with true lambdoid synostosis. 61
20124803 2010
43
Single sutural craniosynostoses: surgical outcomes and long-term growth. 61
19182624 2009
44
Comparison of computed tomographic imaging measurements with clinical findings in children with unilateral lambdoid synostosis. 61
19116566 2009
45
Regarding true lambdoid synostosis: long-term results of surgical and conservative therapy. 61
18626400 2008
46
Familial lambdoid craniosynostosis between father and son. 61
18520419 2008
47
[Cranial vault reconstruction of plagiocephaly]. 61
18269014 2007
48
The diagnosis and treatment of single-sutural synostoses: are computed tomographic scans necessary? 61
17898608 2007
49
True lambdoid craniosynostosis: long-term results of surgical and conservative therapy. 61
17805129 2007
50
[Skull plasty to correct congenital craniosynostosis]. 61
17926845 2007

Variations for Lambdoid Synostosis

Expression for Lambdoid Synostosis

Search GEO for disease gene expression data for Lambdoid Synostosis.

Pathways for Lambdoid Synostosis

GO Terms for Lambdoid Synostosis

Sources for Lambdoid Synostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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