MCID: LNG004
MIFTS: 34

Langerhans Cell Sarcoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Langerhans Cell Sarcoma

MalaCards integrated aliases for Langerhans Cell Sarcoma:

Name: Langerhans Cell Sarcoma 12 54 60 45 15 17 74
Malignant Langerhans Cell Sarcoma 54

Characteristics:

Orphanet epidemiological data:

60
langerhans cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:7146
MeSH 45 D054752
NCIt 51 C6921
ICD10 34 C96.4
MESH via Orphanet 46 D054752
ICD10 via Orphanet 35 C96.4
UMLS via Orphanet 75 C1260327
Orphanet 60 ORPHA86897
UMLS 74 C1260327

Summaries for Langerhans Cell Sarcoma

Disease Ontology : 12 A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.

MalaCards based summary : Langerhans Cell Sarcoma, also known as malignant langerhans cell sarcoma, is related to dendritic cell tumor and histiocytosis. An important gene associated with Langerhans Cell Sarcoma is CD207 (CD207 Molecule), and among its related pathways/superpathways are Tight junction and Immune response Lectin induced complement pathway. Affiliated tissues include lung, bone and spleen.

Wikipedia : 77 Langerhans cell sarcoma is a form of malignant histiocytosis. It should not be confused with Langerhans... more...

Related Diseases for Langerhans Cell Sarcoma

Graphical network of the top 20 diseases related to Langerhans Cell Sarcoma:



Diseases related to Langerhans Cell Sarcoma

Symptoms & Phenotypes for Langerhans Cell Sarcoma

Drugs & Therapeutics for Langerhans Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Langerhans Cell Sarcoma

Cochrane evidence based reviews: langerhans cell sarcoma

Genetic Tests for Langerhans Cell Sarcoma

Anatomical Context for Langerhans Cell Sarcoma

MalaCards organs/tissues related to Langerhans Cell Sarcoma:

42
Lung, Bone, Spleen, B Cells, Lymph Node, Skin, Breast

Publications for Langerhans Cell Sarcoma

Articles related to Langerhans Cell Sarcoma:

(show top 50) (show all 62)
# Title Authors Year
1
Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis: A case report. ( 30855438 )
2019
2
RASA1 loss in a BRAF-mutated Langerhans cell sarcoma: a mechanism of resistance to BRAF inhibitor. ( 30977771 )
2019
3
Incidence, Clinical Features, and Outcomes of Langerhans Cell Sarcoma in the United States. ( 31005630 )
2019
4
Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node. ( 30255584 )
2018
5
Liquid-based cytology in the diagnosis of Langerhans cell sarcoma: A case report. ( 29673124 )
2018
6
Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy. ( 30305476 )
2018
7
Pegylated interferon-α2b for local control of Langerhans cell sarcoma. ( 30355544 )
2018
8
A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing. ( 28614815 )
2017
9
Cytological findings of langerhans cell sarcoma in a case of quintuple cancer. ( 28233936 )
2017
10
Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. ( 28626593 )
2017
11
Langerhans cell sarcoma of the skin in association with superficial atypical Langerhans cell proliferation. ( 29218135 )
2017
12
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. ( 27980300 )
2016
13
A case of an adult Langerhans cell sarcoma. ( 25312302 )
2016
14
Cutaneous and breast Langerhans cell sarcoma. ( 26332733 )
2016
15
Langerhans cell sarcoma of the head and neck. ( 26777877 )
2016
16
Langerhans cell sarcoma: an unusual microscopic presentation. ( 27373133 )
2016
17
Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma. ( 27502715 )
2016
18
Langerhans cell sarcoma: a case report and review of the literature. ( 27543873 )
2016
19
Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review. ( 27900055 )
2016
20
Cutaneous Langerhans cell sarcoma relapsing systemically: Complete remission with the EPIG regimen. ( 25186787 )
2015
21
Langerhans cell sarcoma: a systematic review. ( 25805533 )
2015
22
Diagnostic value of Wilms tumor 1 and CD44 in Langerhans cell sarcoma: case series of 4 patients. ( 25837753 )
2015
23
Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity. ( 26286813 )
2015
24
Langerhans cell sarcoma with lineage infidelity/plasticity: a diagnostic challenge and insight into the pathobiology of the disease. ( 26368646 )
2015
25
Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib. ( 26468227 )
2015
26
Langerhans cell sarcoma arising from the root of tongue: a rare case. ( 26823886 )
2015
27
Langerhans Cell Sarcoma in a Chronic Myelogenous Leukemia Patient Undergoing Imatinib Mesylate Therapy: A Case Study and Review of the Literature. ( 24008437 )
2014
28
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. ( 24834110 )
2014
29
Langerhans cell sarcoma: case report and review of world literature. ( 24942035 )
2014
30
Rare case of Langerhans cell sarcoma with cutaneous manifestation arising on the inguinal region. ( 25387842 )
2014
31
Langerhans cell sarcoma: a case report and review of the literature. ( 23557341 )
2014
32
Clinical experience of bendamustine for adult Langerhans cell sarcoma. ( 24881923 )
2014
33
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study. ( 23923114 )
2013
34
Langerhans cell sarcoma of the nasopharynx: a rare case. ( 24215052 )
2013
35
Langerhans Cell Sarcoma of the Axillary Lymph Node: A Case Report and Review of the Literature. ( 26923635 )
2013
36
Paraneoplastic disseminated lentigines heralding aggressive Langerhans cell sarcoma. ( 22992981 )
2013
37
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. ( 23051626 )
2013
38
Langerhans cell sarcoma in the cervical lymph node: a case report and literature review. ( 23207655 )
2013
39
Expression and anatomical distribution of TIM-containing molecules in Langerhans cell sarcoma. ( 23264111 )
2013
40
Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement. ( 23388086 )
2013
41
Langerhans cell sarcoma: a case report. ( 23590692 )
2013
42
Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence. ( 23690723 )
2013
43
Langerhans cell sarcoma in a patient with hairy cell leukemia: common clonal origin indicated by identical immunoglobulin gene rearrangements. ( 22616604 )
2012
44
The characteristic expression of B7-associated proteins in Langerhans cell sarcoma. ( 22305414 )
2012
45
The characteristics of FDG PET/CT imaging in pulmonary Langerhans cell sarcoma. ( 22475903 )
2012
46
Multifocal Langerhans cell sarcoma involving epidermis: a case report and review. ( 22889043 )
2012
47
Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression. ( 23006414 )
2012
48
Langerhans cell sarcoma of the cervical lymph node: a case report and literature review. ( 20554413 )
2010
49
Langerhans cell sarcoma: Response to radiotherapy. ( 24376934 )
2010
50
Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report. ( 18805873 )
2009

Variations for Langerhans Cell Sarcoma

Expression for Langerhans Cell Sarcoma

Search GEO for disease gene expression data for Langerhans Cell Sarcoma.

Pathways for Langerhans Cell Sarcoma

GO Terms for Langerhans Cell Sarcoma

Cellular components related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.1 CD1A CD1E CD207 CR1 CR2 VSIG4
2 cell surface GO:0009986 8.65 CR1

Biological processes related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.58 CR1 CR2 VSIG4
2 immune system process GO:0002376 9.56 CD1A CD1E CR1 CR2
3 immune response GO:0006955 9.54 CD1A CD1E CR2
4 complement activation, classical pathway GO:0006958 9.48 CR1 CR2
5 regulation of complement activation GO:0030449 9.46 CR1 CR2
6 viral entry into host cell GO:0046718 9.43 CR1 CR2
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.32 CD1A CD1E
8 complement receptor mediated signaling pathway GO:0002430 9.16 CR1 CR2
9 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.96 CD1A CD1E
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.62 CD1A CD1E

Molecular functions related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.26 CR1 CR2
2 lipopeptide binding GO:0071723 9.16 CD1A CD1E
3 endogenous lipid antigen binding GO:0030883 8.96 CD1A CD1E
4 exogenous lipid antigen binding GO:0030884 8.62 CD1A CD1E

Sources for Langerhans Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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