Langerhans Cell Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ A rare dendritic cell tumor characterized by an aggressive, high-grade neoplasm derived from Langerhans cells, most commonly extranodal and multifocal, involving the skin and underlying soft tissue, as well as lung, liver, spleen, and bone. Primary nodal involvement is seen in a minority of patients. Immune-phenotyping and the presence of Birbeck granules on ultrastructural examination reveal the Langerhans cell derivation of the neoplastic cells. Prognosis is generally poor.

MalaCards based summary: Langerhans Cell Sarcoma, also known as malignant langerhans cell sarcoma, is related to histiocytosis and langerhans cell histiocytosis. An important gene associated with Langerhans Cell Sarcoma is CD207 (CD207 Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include spleen, bone marrow and lung.

Orphanet: ⁵⁸ A rare dendritic cell tumor characterized by an aggressive, high-grade neoplasm derived from Langerhans cells, most commonly extranodal and multifocal, involving the skin and underlying soft tissue, as well as lung, liver, spleen, and bone. Primary nodal involvement is seen in a minority of patients. Immune-phenotyping and the presence of Birbeck granules on ultrastructural examination reveal the Langerhans cell derivation of the neoplastic cells. Prognosis is generally poor.

Disease Ontology: ¹¹ A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.

Wikipedia: ⁷⁵ Langerhans cell sarcoma (LCS) is a rare form of malignant histiocytosis. It should not be confused with... more...

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Related Diseases for Langerhans Cell Sarcoma

Diseases related to Langerhans Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)

#	Related Disease	Score	Top Affiliating Genes
1	histiocytosis	31.0	CD207 CD1C CD1A
2	langerhans cell histiocytosis	29.5	CD68 CD207 CD1E CD1D CD1C CD1B
3	histiocytic and dendritic cell cancer	27.8	CR2 CR1 CD68 CD207 CD1E CD1D
4	sarcoma	10.8
5	leukemia, chronic lymphocytic	10.2
6	follicular lymphoma	10.2
7	burkitt lymphoma	10.2
8	leukemia, acute myeloid	10.2
9	lymphoma	10.2
10	leukemia	10.2
11	hematologic cancer	10.2
12	chronic lymphocytic leukemia/small lymphocytic lymphoma	10.2
13	b-cell lymphoma	10.2
14	acute myeloid leukemia with recurrent genetic anomaly	10.2
15	dendritic cell tumor	10.2
16	rare tumor	10.2
17	inflamed seborrheic keratosis	10.1	CD1E CD1A
18	lobomycosis	10.0	CR2 CD1E
19	mixed type thymoma	10.0	CD1E CD1B CD1A
20	igg4-related disease	10.0	CD1E CD1A
21	lichen nitidus	10.0	CD1E CD1B CD1A
22	epithelial malignant thymoma	10.0	CD1E CD1B CD1A
23	cortical thymoma	10.0	CD1E CD1B CD1A
24	mixed phenotype acute leukemia, t/myeloid	10.0	CD1E CD1B CD1A
25	kimura disease	10.0	CD1E CD1B CD1A
26	geographic tongue	10.0	CD1E CD1B CD1A
27	interstitial pneumonitis, desquamative, familial	10.0	CD1E CD1B CD1A
28	mite infestation	10.0	CD1E CD1B CD1A
29	folliculitis	10.0	CD1E CD1B CD1A
30	oral hairy leukoplakia	10.0	CR2 CD1A
31	verruciform xanthoma of skin	10.0	CD68 CD1E
32	lentigines	9.9
33	wilms tumor 1	9.9
34	sjogren syndrome	9.9
35	wilms tumor 5	9.9
36	leukemia, chronic myeloid	9.9
37	aplastic anemia	9.9
38	leukemia, acute lymphoblastic	9.9
39	aspergillosis	9.9
40	myelodysplastic syndrome	9.9
41	bacterial sepsis	9.9
42	invasive aspergillosis	9.9
43	marginal zone b-cell lymphoma	9.9
44	nodal marginal zone lymphoma	9.9
45	nodular malignant melanoma	9.9
46	sialadenitis	9.9
47	pancytopenia	9.9
48	acute leukemia	9.9
49	brain cancer	9.9
50	melanoma	9.9

Graphical network of the top 20 diseases related to Langerhans Cell Sarcoma:

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Symptoms & Phenotypes for Langerhans Cell Sarcoma

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Drugs & Therapeutics for Langerhans Cell Sarcoma

Search Clinical Trials, NIH Clinical Center for Langerhans Cell Sarcoma

Cochrane evidence based reviews: langerhans cell sarcoma

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Genetic Tests for Langerhans Cell Sarcoma

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Anatomical Context for Langerhans Cell Sarcoma

Organs/tissues related to Langerhans Cell Sarcoma:

MalaCards : Spleen, Bone Marrow, Lung, Liver, Bone, Skin, Lymph Node

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Publications for Langerhans Cell Sarcoma

Articles related to Langerhans Cell Sarcoma:

(show top 50) (show all 123)

#	Title	Authors	PMID	Year
1	Left Forearm Langerhans Cell Sarcoma Demonstrated by 18 F-FDG PET/CT. ⁶²	He L...Zhang W	35835140	2022
2	Prolonged remission with pembrolizumab and radiation therapy in a patient with multisystem Langerhans cell sarcoma. ⁶²	Zanwar S...Go RS	35615932	2022
3	Langerhans cell sarcoma arising after antecedent Langerhans cell histiocytosis in lymphoepithelial sialadenitis of Sjögren's syndrome. ⁶²	Mihara Y...Yamakawa M	35583172	2022
4	Differential Diagnosis of Rare Diseases Involving Bilateral Lower Extremities with Similar 99mTc-MDP Bone Scan Patterns: Analysis of a Case Series. ⁶²	Sun Z...Shen C	35453958	2022
5	Unusual presentation of Langerhans cell sarcoma as bilateral submandibular gland swelling - A rare case report. ⁶²	Mohanty P...Bhattacharyya S	35645054	2022
6	Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone. ⁶²	Xie S...Jiang Z	35747436	2022
7	Langerhans cell sarcoma with BRAF-V600E mutation and hemophagocytosis: An autopsy report. ⁶²	Madakshira MG...Bal A	35645053	2022
8	Chronic lymphocytic leukemia/small lymphocytic lymphoma complicated with skin Langerhans cell sarcoma: A case report. ⁶²	Li SY...Wang LH	35005006	2021
9	A Pedigree Analysis and Clonal Correlations of the Coexistence of B-Cell Lymphoma and Histiocytic/Dendritic Cell Tumor. ⁶²	Cheng F...Wang Z	33939500	2021
10	Concurrent follicular lymphoma and Langerhans cell sarcoma. ⁶²	Tashakori M...Medeiros LJ	35845209	2021
11	Histiocytic disorders. ⁶²	McClain KL...Allen CE	34620874	2021
12	The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma. ⁶²	Yashige K...Haga H	34497165	2021
13	Adult-onset perianal Langerhans cell histiocytosis presenting as pruritus ani: a case report and review of the literature. ⁶²	Hamdan M...Fikfak V	34289900	2021
14	From the archives of MD Anderson Cancer Center: A case of concurrent follicular lymphoma and Langerhans cell sarcoma with a review of the literature. ⁶²	Tashakori M...Medeiros LJ	33676171	2021
15	Langerhans cell sarcoma involving skin and showing epidermotropism: A comprehensive review. ⁶²	Ronen S...Torres-Cabala CA	32644218	2021
16	Histiocytosis and Neoplasms of Macrophage-Dendritic Cell Lineages: Multimodality Imaging with Emphasis on PET/CT. ⁶²	Huynh KN...Nguyen BD	33606566	2021
17	[Primary cutaneous Langerhans cell sarcoma: report of a case]. ⁶²	Ma LL...Yang SJ	33677899	2021
18	Epstein-Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report. ⁶²	Guo Y...Yao HT	35117987	2021
19	Nodal Langerhans cell neoplasm: detailing the diagnostic quandaries. ⁶²	Chowdhury Z...Khaddar S	35004363	2021
20	Histiocytic and dendritic cell neoplasms: Reappraisal of a Japanese series based on t(14;18) and neoplastic PD-L1 expression. ⁶²	Okada K...Nakamura S	33238073	2021
21	Bone marrow coexistence of chronic lymphocytic leukemia and Langerhans cell sarcoma. ⁶²	Zanelli M...Ascani S	32621179	2020
22	A case of Langerhans cell sarcoma on the scalp: Whole-exome sequencing reveals a role of ultraviolet in the pathogenesis. ⁶²	Katsuragawa H...Haga H	33410565	2020
23	Adult Langerhans cell histiocytosis presenting with multisystem involvement and sarcomatoid features: a case report. ⁶²	Aguirre LE...Alencar A	32979930	2020
24	Langerhans cell sarcoma of the vulva: Case report and review of the literature. ⁶²	Tillit S...Goicoechea JC	32346590	2020
25	Concurrent cutaneous localization of Langerhans cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma. ⁶²	Papoudou-Bai A...Kanavaros P	31441945	2020
26	TIM-3 expression and its association with overall survival in primary osteosarcoma. ⁶²	Pu F...Shao Z	31612039	2019
27	Unusual Presentation of a Rare Tumor: Histiocytic Sarcoma Presenting as a Finger Growth. ⁶²	Ali Z...Hanif F	31890359	2019
28	Efficacy of a Modified Scoring System to Facilitate Surgical Decision-making for Diaphyseal Malignancies: When is Devitalized Tumor-bearing Autograft of Value? ⁶²	Chen Y...Yu XC	31402605	2019
29	RASA1 loss in a BRAF-mutated Langerhans cell sarcoma: a mechanism of resistance to BRAF inhibitor. ⁶²	Jouenne F...Tazi A	30977771	2019
30	Incidence, Clinical Features, and Outcomes of Langerhans Cell Sarcoma in the United States. ⁶²	Tella SH...Goyal G	31005630	2019
31	Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis: A case report. ⁶²	Yi W...Liang WN	30855438	2019
32	Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma. ⁶²	Skala SL...Dewar R	31633108	2019
33	[Durable remission of Langerhans cell sarcoma attained by autologous hematopoietic stem cell transplantation following surgical resection]. ⁶²	Fuseya H...Yamane T	31068562	2019
34	Pegylated interferon-α2b for local control of Langerhans cell sarcoma. ⁶²	Ishitsuka Y...Fujimoto M	30355544	2018
35	Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy. ⁶²	Matsukawa T...Miyagishima T	30305476	2018
36	Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node. ⁶²	Shimono J...Ohshima K	30255584	2018
37	KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma. ⁶²	Choi SM...Gao J	30322385	2018
38	Liquid-based cytology in the diagnosis of Langerhans cell sarcoma: A case report. ⁶²	Iwasaki K...Imamura Y	29673124	2018
39	Merkel cell polyomavirus and Langerhans cell neoplasm. ⁶²	Murakami I...Jaubert F	30134914	2018
40	[Langerhans cell sarcoma: a clinicopathologic analysis of four cases]. ⁶²	Huang HJ...Zheng ZY	29534353	2018
41	CDKN2A/B Deletion and Double-hit Mutations of the MAPK Pathway Underlie the Aggressive Behavior of Langerhans Cell Tumors. ⁶²	Xerri L...Birnbaum D	29194093	2018
42	Histiocytic lesions of the orbit: A study of 9 cases. ⁶²	Gunduz AK...Temel E	29755270	2018
43	Prognostic factors for histiocytic and dendritic cell neoplasms. ⁶²	Shimono J...Ohshima K	29228722	2017
44	Langerhans cell sarcoma of the skin in association with superficial atypical Langerhans cell proliferation. ⁶²	Soler AP...Smith TL	29218135	2017
45	[Langerhans cell sarcoma: two cases report and literature rewiew]. ⁶²	Wang L	28926905	2017
46	Cytological findings of langerhans cell sarcoma in a case of quintuple cancer. ⁶²	Tabata S...Sawada N	28233936	2017
47	Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. ⁶²	Singh R...Sarsfield P	28626593	2017
48	A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing. ⁶²	Kim SW...Kwon J	28614815	2017
49	Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma. ⁶²	Lorillon G...Tazi A	27502715	2016
50	High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms. ⁶²	Huang W...Feng X	27823979	2016

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Genes for Langerhans Cell Sarcoma

Genes related to Langerhans Cell Sarcoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD207	CD207 Molecule	Protein Coding	16.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	CD1A	CD1a Molecule	Protein Coding	16.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	IGF2BP3	Insulin Like Growth Factor 2 MRNA Binding Protein 3	Protein Coding	11.74	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	CD1E	CD1e Molecule	Protein Coding	7.85	DISEASES inferred ¹⁴
5	CD1B	CD1b Molecule	Protein Coding	7.8	DISEASES inferred ¹⁴
6	CD1C	CD1c Molecule	Protein Coding	7.66	DISEASES inferred ¹⁴
7	CD1D	CD1d Molecule	Protein Coding	7.54	DISEASES inferred ¹⁴
8	CR2	Complement C3d Receptor 2	Protein Coding	6.36	DISEASES inferred ¹⁴
9	CD68	CD68 Molecule	Protein Coding	6.31	DISEASES inferred ¹⁴
10	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	6.06	DISEASES inferred ¹⁴
11	TIMD4	T Cell Immunoglobulin And Mucin Domain Containing 4	Protein Coding	5.77	DISEASES inferred ¹⁴

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Variations for Langerhans Cell Sarcoma

Cosmic variations for Langerhans Cell Sarcoma:

⁸ (show top 50) (show all 109)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM87903333	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
2	COSM112319175	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
3	COSM145022367	TP53	soft tissue,liver,sarcoma,NS	c.529G>A	p.V177M	17:7674885-7674885	9
4	COSM93250304	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
5	COSM111826264	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
6	COSM112257487	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
7	COSM142840682	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
8	COSM144718997	TP53	soft tissue,liver,sarcoma,NS	c.242A>T	p.K81M	17:7676010-7676010	9
9	COSM144313969	TP53	soft tissue,liver,sarcoma,NS	c.529G>A	p.V177M	17:7674885-7674885	9
10	COSM111763428	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
11	COSM142892050	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
12	COSM105695818	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
13	COSM143947706	TP53	soft tissue,liver,sarcoma,NS	c.169G>A	p.V57M	17:7674885-7674885	9
14	COSM87975568	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
15	COSM144090111	TP53	soft tissue,liver,sarcoma,NS	c.169G>A	p.V57M	17:7674885-7674885	9
16	COSM93188160	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
17	COSM105625297	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
18	COSM122738565	TP53	soft tissue,liver,sarcoma,NS	c.250G>A	p.V84M	17:7674885-7674885	9
19	COSM144656180	TP53	soft tissue,liver,sarcoma,NS	c.529G>A	p.V177M	17:7674885-7674885	9
20	COSM121881499	TP53	soft tissue,liver,sarcoma,NS	c.250G>A	p.V84M	17:7674885-7674885	9
21	COSM145076613	TP53	soft tissue,liver,sarcoma,NS	c.242A>T	p.K81M	17:7676010-7676010	9
22	COSM122275696	TP53	soft tissue,liver,sarcoma,NS	c.250G>A	p.V84M	17:7674885-7674885	9
23	COSM144364047	TP53	soft tissue,liver,sarcoma,NS	c.242A>T	p.K81M	17:7676010-7676010	9
24	COSM143160205	TP53	soft tissue,liver,sarcoma,NS	c.169G>A	p.V57M	17:7674885-7674885	9
25	COSM143433111	TP53	soft tissue,liver,sarcoma,NS	c.242A>T	p.K81M	17:7676010-7676010	9
26	COSM142564545	TP53	soft tissue,liver,sarcoma,NS	c.529G>A	p.V177M	17:7674885-7674885	9
27	COSM143375373	TP53	soft tissue,liver,sarcoma,NS	c.529G>A	p.V177M	17:7674885-7674885	9
28	COSM106116663	TP53	soft tissue,liver,sarcoma,NS	c.359A>T	p.K120M	17:7676010-7676010	9
29	COSM144017945	TP53	soft tissue,liver,sarcoma,NS	c.613G>A	p.V205M	17:7674885-7674885	9
30	COSM142627250	TP53	soft tissue,liver,sarcoma,NS	c.242A>T	p.K81M	17:7676010-7676010	9
31	COSM144072930	TP53	soft tissue,liver,sarcoma,NS	c.340+15A>T	p.?	17:7676010-7676010	9
32	COSM106057273	TP53	soft tissue,liver,sarcoma,NS	c.646G>A	p.V216M	17:7674885-7674885	9
33	COSM97107943	NRAS	soft tissue,skin,sarcoma,NS	c.38G>C	p.G13A	1:114716123-114716123	9
34	COSM93992510	SRC	soft tissue,lung,sarcoma,NS	c.205T>G	p.S69A	20:37384358-37384358	8
35	COSM98338978	SRC	soft tissue,lung,sarcoma,NS	c.205T>G	p.S69A	20:37384358-37384358	8
36	COSM98373331	SRC	soft tissue,lung,sarcoma,NS	c.205T>G	p.S69A	20:37384358-37384358	8
37	COSM93554172	SRC	soft tissue,lung,sarcoma,NS	c.205T>G	p.S69A	20:37384358-37384358	8
38	COSM89629521	SF3B1	soft tissue,liver,other,neoplasm	c.2014G>T	p.A672S	2:197402619-197402619	8
39	COSM93451505	RAC1	soft tissue,lung,sarcoma,NS	c.533C>T	p.A178V	7:6402343-6402343	8
40	COSM92729038	RAC1	soft tissue,lung,sarcoma,NS	c.476C>T	p.A159V	7:6402343-6402343	8
41	COSM117948203	PTPRD	soft tissue,lung,sarcoma,NS	c.2939C>T	p.A980V	9:8404587-8404587	8
42	COSM132326062	PTPRD	soft tissue,lung,sarcoma,NS	c.4160C>T	p.A1387V	9:8404587-8404587	8
43	COSM91028178	PTPRD	soft tissue,lung,sarcoma,NS	c.2942C>T	p.A981V	9:8404587-8404587	8
44	COSM101931022	PTPRD	soft tissue,lung,sarcoma,NS	c.4160C>T	p.A1387V	9:8404587-8404587	8
45	COSM132607215	PTPRD	soft tissue,lung,sarcoma,NS	c.2912C>T	p.A971V	9:8404587-8404587	8
46	COSM102156539	PTPRD	soft tissue,lung,sarcoma,NS	c.2930C>T	p.A977V	9:8404587-8404587	8
47	COSM102254463	PTPRD	soft tissue,lung,sarcoma,NS	c.2939C>T	p.A980V	9:8404587-8404587	8
48	COSM92957889	PTPRD	soft tissue,lung,sarcoma,NS	c.4160C>T	p.A1387V	9:8404587-8404587	8
49	COSM102059370	PTPRD	soft tissue,lung,sarcoma,NS	c.2939C>T	p.A980V	9:8404587-8404587	8
50	COSM106841030	PTCH1	soft tissue,lung,sarcoma,NS	c.2468T>G	p.F823C	9:95458260-95458260	8

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Expression for Langerhans Cell Sarcoma

Search GEO for disease gene expression data for Langerhans Cell Sarcoma.

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Pathways for Langerhans Cell Sarcoma

Pathways related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.41	CR2 CR1 CD68 CD207 CD1D CD1C
2	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing: Ubiquitination and Proteasome degradation ⁶⁶ Neddylation ⁶⁶	12.95	CD207 CD1D CD1C CD1B CD1A
3	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.38	CD1D CD1C CD1B CD1A
4	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.18	CR2 CR1 CD1D
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.79	CD207 CD1D CD1C CD1A

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GO Terms for Langerhans Cell Sarcoma

Cellular components related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.68	TIMD4 CR2 CR1 CD68 CD207 CD1E
2	plasma membrane	GO:0005887	10.68	CR1 CD1E CD1D CD1C CD1A
3	extracellular space	GO:0005615	10.21	CR2 CR1 CD1E CD1D CD1C CD1B
4	membrane	GO:0016021	10.02	CD1A CD1B CD1C CD1D CD1E CD207
5	membrane	GO:0016020	10.02	CD1A CD1B CD1C CD1D CD1E CD207
6	lysosome	GO:0005764	9.92	CD1B CD1C CD1D CD1E CD68
7	endosome membrane	GO:0010008	9.91	CD68 CD1D CD1C CD1B CD1A
8	endosome	GO:0005768	9.63	CD68 CD1E CD1D CD1C CD1B CD1A
9	external side of plasma membrane	GO:0009897	9.4	CD207 CD1E CD1D CD1C CD1B CD1A

Biological processes related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	10.06	CD1E CD1C CD1B CD1A
2	immune response	GO:0006955	9.97	CR2 CD1E CD1D CD1C CD1B CD1A
3	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.85	CD1E CD1D CD1C CD1B CD1A
4	immune system process	GO:0002376	9.8	CD1A CD1B CD1C CD1D CD1E CR1
5	complement activation, alternative pathway	GO:0006957	9.73	CR2 CR1
6	complement receptor mediated signaling pathway	GO:0002430	9.71	CR2 CR1
7	negative regulation of complement activation, classical pathway	GO:0045959	9.67	CR2 CR1
8	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.65	CD1E CD1D CD1C CD1B CD1A
9	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.32	CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.85	CD1E CD1D CD1C CD1B CD1A
2	exogenous lipid antigen binding	GO:0030884	9.65	CD1E CD1D CD1C CD1B CD1A
3	endogenous lipid antigen binding	GO:0030883	9.32	CD1E CD1D CD1C CD1B CD1A

Sources

Sources for Langerhans Cell Sarcoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LNG004 MIFTS: 40	Langerhans Cell Sarcoma Categories: Blood diseases, Cancer diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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