MCID: LNG004
MIFTS: 34

Langerhans Cell Sarcoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Langerhans Cell Sarcoma

MalaCards integrated aliases for Langerhans Cell Sarcoma:

Name: Langerhans Cell Sarcoma 12 53 59 44 15 73
Malignant Langerhans Cell Sarcoma 53

Characteristics:

Orphanet epidemiological data:

59
langerhans cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:7146
ICD10 33 C96.4
MeSH 44 D054752
NCIt 50 C6921
Orphanet 59 ORPHA86897
MESH via Orphanet 45 D054752
UMLS via Orphanet 74 C1260327
ICD10 via Orphanet 34 C96.4
UMLS 73 C1260327

Summaries for Langerhans Cell Sarcoma

Disease Ontology : 12 A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.

MalaCards based summary : Langerhans Cell Sarcoma, also known as malignant langerhans cell sarcoma, is related to dendritic cell tumor and langerhans cell histiocytosis. An important gene associated with Langerhans Cell Sarcoma is CD207 (CD207 Molecule), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Complement and coagulation cascades. Affiliated tissues include lung, bone and spleen.

Wikipedia : 76 Langerhans cell sarcoma is a form of malignant histiocytosis. It should not be confused with Langerhans... more...

Related Diseases for Langerhans Cell Sarcoma

Diseases related to Langerhans Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 dendritic cell tumor 31.5 CD1A CD207 CR1 CR2
2 langerhans cell histiocytosis 30.0 CD163 CD1A CD207
3 histiocytosis 29.9 CD163 CD1A CD207
4 sarcoma 10.7
5 alk+ histiocytosis 10.1 CD1A CD207
6 lymphoma 10.1
7 spindle cell sarcoma 10.1
8 parapharyngeal meningioma 10.0 CR1 CR2
9 cavernous sinus meningioma 10.0 CD163 CD207
10 non-langerhans-cell histiocytosis 10.0 CD163 CD207
11 reticulum cell sarcoma 10.0 CR1 CR2
12 lateral medullary syndrome 10.0 CR1 CR2
13 leukemia 10.0
14 reticulohistiocytic granuloma 10.0 CD163 CD207
15 castleman disease 10.0 CR1 CR2
16 rosai-dorfman disease 10.0 CD163 CR2
17 central nervous system tuberculosis 10.0 CD163 CD207
18 follicular dendritic cell sarcoma 10.0 CR1 CR2
19 inflammatory myofibroblastic tumor 9.9 CR1 CR2
20 spindle cell liposarcoma 9.9 CR2 HBA1
21 t-cell/histiocyte rich large b cell lymphoma 9.9 CR1 CR2 VSIG4
22 lentigines 9.8
23 wilms tumor 1 9.8
24 leukemia, chronic myeloid 9.8
25 wilms tumor 6 9.8
26 follicular lymphoma 9.8
27 lymphocytic leukemia 9.8
28 hairy cell leukemia 9.8
29 infiltrating lipoma 9.8 CD163 HBA1
30 histiocytic sarcoma 9.8 CD163 CR1 CR2
31 interdigitating dendritic cell sarcoma 9.8 CD163 CR1 CR2
32 hemophagocytic lymphohistiocytosis 9.8 CR1 CR2
33 spleen cancer 9.7 CD163 CR2 HBA1
34 histiocytic and dendritic cell cancer 9.7 CD163 CD207 CR1 CR2
35 malaria 9.5 CD163 CR1 HBA1

Graphical network of the top 20 diseases related to Langerhans Cell Sarcoma:



Diseases related to Langerhans Cell Sarcoma

Symptoms & Phenotypes for Langerhans Cell Sarcoma

Drugs & Therapeutics for Langerhans Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Langerhans Cell Sarcoma

Cochrane evidence based reviews: langerhans cell sarcoma

Genetic Tests for Langerhans Cell Sarcoma

Anatomical Context for Langerhans Cell Sarcoma

MalaCards organs/tissues related to Langerhans Cell Sarcoma:

41
Lung, Bone, Spleen, Lymph Node, B Cells, T Cells, Myeloid

Publications for Langerhans Cell Sarcoma

Articles related to Langerhans Cell Sarcoma:

(show top 50) (show all 59)
# Title Authors Year
1
Liquid-based cytology in the diagnosis of Langerhans cell sarcoma: A case report. ( 29673124 )
2018
2
Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node. ( 30255584 )
2018
3
Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy. ( 30305476 )
2018
4
Pegylated interferon-α2b for local control of Langerhans cell sarcoma. ( 30355544 )
2018
5
Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. ( 28626593 )
2017
6
Cytological findings of langerhans cell sarcoma in a case of quintuple cancer. ( 28233936 )
2017
7
A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing. ( 28614815 )
2017
8
Langerhans cell sarcoma of the skin in association with superficial atypical Langerhans cell proliferation. ( 29218135 )
2017
9
Langerhans cell sarcoma of the head and neck. ( 26777877 )
2016
10
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. ( 27980300 )
2016
11
Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review. ( 27900055 )
2016
12
Langerhans cell sarcoma: an unusual microscopic presentation. ( 27373133 )
2016
13
Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma. ( 27502715 )
2016
14
Langerhans cell sarcoma: a case report and review of the literature. ( 27543873 )
2016
15
A case of an adult Langerhans cell sarcoma. ( 25312302 )
2016
16
Langerhans cell sarcoma arising from the root of tongue: a rare case. ( 26823886 )
2015
17
Langerhans cell sarcoma: A systematic review. ( 25805533 )
2015
18
Cutaneous and breast Langerhans cell sarcoma. ( 26332733 )
2015
19
Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity. ( 26286813 )
2015
20
Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib. ( 26468227 )
2015
21
Langerhans cell sarcoma with lineage infidelity/plasticity: a diagnostic challenge and insight into the pathobiology of the disease. ( 26368646 )
2015
22
Diagnostic Value of Wilms Tumor 1 and CD44 in Langerhans Cell Sarcoma: Case Series of 4 Patients. ( 25837753 )
2015
23
Cutaneous Langerhans cell sarcoma relapsing systemically: Complete remission with the EPIG regimen. ( 25186787 )
2014
24
Clinical experience of bendamustine for adult Langerhans cell sarcoma. ( 24881923 )
2014
25
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. ( 24834110 )
2014
26
Langerhans cell sarcoma: case report and review of world literature. ( 24942035 )
2014
27
Rare case of Langerhans cell sarcoma with cutaneous manifestation arising on the inguinal region. ( 25387842 )
2014
28
Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence. ( 23690723 )
2013
29
Langerhans cell sarcoma: a case report. ( 23590692 )
2013
30
Langerhans Cell Sarcoma of the Axillary Lymph Node: A Case Report and Review of the Literature. ( 26923635 )
2013
31
Paraneoplastic disseminated lentigines heralding aggressive Langerhans cell sarcoma. ( 22992981 )
2013
32
Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement. ( 23388086 )
2013
33
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. ( 23051626 )
2013
34
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study. ( 23923114 )
2013
35
Langerhans Cell Sarcoma in a Chronic Myelogenous Leukemia Patient Undergoing Imatinib Mesylate Therapy: A Case Study and Review of the Literature. ( 24008437 )
2013
36
Langerhans cell sarcoma of the nasopharynx: a rare case. ( 24215052 )
2013
37
Expression and anatomical distribution of TIM-containing molecules in Langerhans cell sarcoma. ( 23264111 )
2013
38
Langerhans cell sarcoma: a case report and review of the literature. ( 23557341 )
2013
39
Langerhans cell sarcoma in the cervical lymph node: a case report and literature review. ( 23207655 )
2013
40
Multifocal Langerhans cell sarcoma involving epidermis: a case report and review. ( 22889043 )
2012
41
The characteristic expression of B7-associated proteins in Langerhans cell sarcoma. ( 22305414 )
2012
42
The characteristics of FDG PET/CT imaging in pulmonary Langerhans cell sarcoma. ( 22475903 )
2012
43
Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression. ( 23006414 )
2012
44
Langerhans cell sarcoma in a patient with hairy cell leukemia: common clonal origin indicated by identical immunoglobulin gene rearrangements. ( 22616604 )
2012
45
Langerhans cell sarcoma of the cervical lymph node: a case report and literature review. ( 20554413 )
2010
46
Langerhans cell sarcoma: Response to radiotherapy. ( 24376934 )
2010
47
Chemotherapy for Langerhans cell sarcoma. ( 19337819 )
2009
48
Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report. ( 18805873 )
2009
49
ESHAP therapy effective in a patient with Langerhans cell sarcoma. ( 18415657 )
2008
50
Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen. ( 18274862 )
2008

Variations for Langerhans Cell Sarcoma

Expression for Langerhans Cell Sarcoma

Search GEO for disease gene expression data for Langerhans Cell Sarcoma.

Pathways for Langerhans Cell Sarcoma

GO Terms for Langerhans Cell Sarcoma

Cellular components related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.43 CD163 CD1A CD207 CR1 CR2 VSIG4
2 membrane GO:0016020 9.17 CD163 CD1A CD207 CR1 CR2 HBA1

Biological processes related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.54 CD1A CR1 CR2
2 innate immune response GO:0045087 9.43 CR1 CR2 VSIG4
3 regulation of complement activation GO:0030449 9.32 CR1 CR2
4 viral entry into host cell GO:0046718 9.16 CR1 CR2
5 receptor-mediated endocytosis GO:0006898 9.13 CD163 CD207 HBA1
6 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Molecular functions related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR1 CR2

Sources for Langerhans Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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