MCID: LRG002
MIFTS: 28

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Large Cell Acanthoma

MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4321
NCIt 51 C27518
UMLS 74 C1334362

Summaries for Large Cell Acanthoma

MalaCards based summary : Large Cell Acanthoma is related to acanthoma and bowen's disease. An important gene associated with Large Cell Acanthoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is integument.

Wikipedia : 77 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

Related Diseases for Large Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 acanthoma 31.4 KRT10 KRT17
2 bowen's disease 29.9 KRT10 KRT17 KRT7
3 papilloma 29.4 KRT10 KRT14 KRT5 KRT7
4 eccrine acrospiroma 10.3 KRT10 KRT17
5 steatocystoma multiplex 10.3 KRT10 KRT17
6 striate palmoplantar keratoderma 10.2 KRT10 KRT14
7 keratoacanthoma 10.2 KRT10 KRT17
8 clear cell basal cell carcinoma 10.2 KRT17 KRT7
9 pachyonychia congenita 1 10.2 KRT10 KRT17
10 hidradenitis suppurativa 10.2 KRT10 KRT14
11 lichen planopilaris 10.2 KRT14 KRT5
12 hidradenitis 10.2 KRT10 KRT14
13 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5
14 pigmented basal cell carcinoma 10.2 KRT14 MLANA
15 vulvar intraepithelial neoplasia 10.1 KRT10 KRT7
16 epidermolysis bullosa simplex, localized 10.1 KRT14 KRT5
17 epidermolysis bullosa simplex, generalized 10.1 KRT14 KRT5
18 pinguecula 10.1 KRT10 KRT14
19 cervical clear cell adenocarcinoma 10.1 KRT14 KRT5
20 odontoma 10.1 KRT14 KRT5
21 cystic basal cell carcinoma 10.1 KRT7 PTGER4
22 anus basaloid carcinoma 10.1 KRT7 PTGER4
23 ampulla of vater adenocarcinoma 10.1 KRT17 KRT7
24 malignant syringoma 10.1 KRT7 PTGER4
25 endosalpingiosis 10.1 KRT7 PTGER4
26 palmoplantar keratoderma, epidermolytic 10.1 KRT10 KRT14
27 vesiculobullous skin disease 10.1 KRT14 KRT5
28 breast benign neoplasm 10.1 KRT14 KRT5
29 ovarian mucinous neoplasm 10.1 KRT17 KRT7
30 thoracic benign neoplasm 10.1 KRT14 KRT5
31 mucinous tubular and spindle renal cell carcinoma 10.1 KRT10 KRT7
32 thymus adenocarcinoma 10.1 KRT7 PTGER4
33 papillary serous adenocarcinoma 10.1 KRT7 PTGER4
34 spiradenoma 10.1 KRT14 KRT7
35 lipid-rich carcinoma 10.1 KRT14 KRT5
36 oncocytic breast carcinoma 10.1 KRT14 KRT7
37 mucoepidermoid carcinoma 10.1 KRT14 KRT7
38 brooke-spiegler syndrome 10.1 KRT14 KRT7
39 sebaceous adenocarcinoma 10.1 KRT5 PTGER4
40 ampulla of vater cancer 10.1 KRT17 KRT7
41 inverted transitional papilloma 10.1 KRT5 KRT7
42 ceruminoma 10.1 KRT5 KRT7
43 malignant spiradenoma 10.1 KRT5 KRT7
44 sarcomatoid squamous cell skin carcinoma 10.1 KRT5 MLANA
45 pericardium cancer 10.1 KRT7 PTGER4
46 sensory organ benign neoplasm 10.1 KRT5 KRT7
47 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
48 middle ear adenoma 10.1 KRT5 KRT7
49 epithelial-myoepithelial carcinoma 10.0 KRT14 KRT7
50 inverted follicular keratosis 10.0 KRT17 MTOR

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma

Symptoms & Phenotypes for Large Cell Acanthoma

MGI Mouse Phenotypes related to Large Cell Acanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 KRT14 KRT17 KRT5 MLANA PTGER4

Drugs & Therapeutics for Large Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

Genetic Tests for Large Cell Acanthoma

Anatomical Context for Large Cell Acanthoma

MalaCards organs/tissues related to Large Cell Acanthoma:

42
Skin

Publications for Large Cell Acanthoma

Articles related to Large Cell Acanthoma:

(show all 16)
# Title Authors Year
1
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
2
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
3
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
4
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
5
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ( 23786782 )
2013
6
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. ( 19719831 )
2010
7
Large cell acanthoma. ( 12581141 )
2003
8
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. ( 8030765 )
1994
9
Large-cell acanthoma is a distinctive condition. ( 1566974 )
1992
10
Large-cell acanthoma. ( 1566973 )
1992
11
Large-cell acanthoma is a solar lentigo. ( 1533104 )
1992
12
Large-cell acanthoma. A distinctive keratosis. ( 1348913 )
1992
13
Large-cell acanthoma of the eyelid. Report of two cases. ( 1929935 )
1991
14
Achromic verrucous large cell acanthoma. ( 2373780 )
1990
15
Large cell acanthoma. A cytologic variant of Bowen's disease? ( 3232750 )
1988
16
Large cell acanthoma. One of the actinic keratoses. ( 619783 )
1978

Variations for Large Cell Acanthoma

Expression for Large Cell Acanthoma

Search GEO for disease gene expression data for Large Cell Acanthoma.

Pathways for Large Cell Acanthoma

Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 KRT10 KRT14 KRT17 KRT5 KRT7
2 11.95 KRT10 KRT17 KRT5 KRT7
3
Show member pathways
11.48 KRT10 KRT14 KRT17 KRT5 KRT7
4 11.35 KRT14 KRT17 KRT5
5
Show member pathways
11.29 KRT14 KRT17 KRT5 KRT7

GO Terms for Large Cell Acanthoma

Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 KRT10 KRT14 KRT17 KRT5 KRT7
2 cell periphery GO:0071944 9.16 KRT14 KRT17
3 keratin filament GO:0045095 9.13 KRT14 KRT5 KRT7
4 intermediate filament GO:0005882 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT10 KRT14 KRT17 KRT5 KRT7
2 epidermis development GO:0008544 9.33 KRT14 KRT17 KRT5
3 positive regulation of translation GO:0045727 9.32 KRT17 MTOR
4 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
5 cornification GO:0070268 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT10 KRT17 KRT7
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT14 KRT17 KRT5

Sources for Large Cell Acanthoma

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11 DGIdb
17 EFO
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20 FMA
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31 HGMD
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35 ICD10 via Orphanet
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50 NCI
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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