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MCID: LRG002
MIFTS: 29

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Large Cell Acanthoma

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MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 70

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4321
NCIt 50 C27518
SNOMED-CT 67 733894009
UMLS 70 C1334362
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Summaries for Large Cell Acanthoma

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MalaCards based summary : Large Cell Acanthoma is related to inverted follicular keratosis and bowen's disease. An important gene associated with Large Cell Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, skin and lung, and related phenotype is pigmentation.

Wikipedia : 73 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

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Related Diseases for Large Cell Acanthoma

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Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 inverted follicular keratosis 31.0 PTGER4 KRT17
2 bowen's disease 30.6 KRT7 KRT10
3 squamous cell papilloma 30.0 TP53 KRT14
4 keratosis 29.9 TP53 KRT5 KRT17 KRT14 KRT10
5 acanthoma 29.8 TP53 TCHH MLANA KRT5 KRT17 KRT10
6 in situ carcinoma 29.6 TP53 KRT5 KRT17 KRT14
7 papilloma 29.1 TP53 KRT7 KRT5 KRT14 KRT10
8 keratosis, seborrheic 28.8 TP53 TCHH MLANA KRT7 KRT5 KRT17
9 clear cell acanthoma 10.7
10 lentigines 10.4
11 actinic keratosis 10.3
12 pigmented basal cell carcinoma 10.3 PTGER4 MLANA
13 striate palmoplantar keratoderma 10.3 KRT14 KRT10
14 pinguecula 10.2 KRT14 KRT10
15 steatocystoma multiplex 10.2 KRT17 KRT10
16 malignant biphasic mesothelioma 10.2 KRT5 KRT10
17 sarcomatoid basal cell carcinoma 10.2 PTGER4 KRT5
18 sarcomatoid squamous cell skin carcinoma 10.2 MLANA KRT5
19 nystagmus 4, congenital, autosomal dominant 10.2 KRT14 KRT10
20 epidermolytic acanthoma 10.2 TCHH KRT10
21 pancreatoblastoma 10.2 KRT14 KRT10
22 micronodular basal cell carcinoma 10.2 KRT5 KRT14
23 breast myoepithelial carcinoma 10.2 KRT5 KRT14
24 intravascular fasciitis 10.2 MLANA ELN
25 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
26 odontoma 10.2 KRT5 KRT14
27 epidermoid cysts 10.2 TCHH KRT17
28 lipid-rich carcinoma 10.2 KRT5 KRT14
29 anal canal paget's disease 10.2 MLANA KRT7
30 anal paget's disease 10.2 MLANA KRT7
31 intrahepatic gall duct cancer 10.1 KRT7 KRT17
32 lichen planus 10.1
33 melanoacanthoma 10.1 MLANA KRT7
34 pulmonary artery leiomyosarcoma 10.1 KRT7 KRT10
35 intracystic papillary adenoma 10.1 KRT5 KRT14
36 vulval paget's disease 10.1 MLANA KRT7
37 anus basaloid carcinoma 10.1 PTGER4 KRT7
38 rete testis neoplasm 10.1 PTGER4 KRT7
39 mucinous tubular and spindle renal cell carcinoma 10.1 KRT7 KRT10
40 rete testis adenocarcinoma 10.1 PTGER4 KRT7
41 schwannoma of twelfth cranial nerve 10.1 MLANA KRT7
42 hypoglossal nerve disease 10.1 MLANA KRT7
43 palmoplantar keratoderma, epidermolytic 10.1 KRT17 KRT14 KRT10
44 uterus perivascular epithelioid cell tumor 10.1 MLANA KRT7
45 epidermolysis bullosa simplex, localized 10.1 KRT5 KRT14
46 squamous papillomatosis 10.1 PTGER4 KRT7
47 ovarian sex-cord stromal tumor 10.1 MLANA KRT7
48 epidermolysis bullosa simplex, generalized 10.1 KRT5 KRT14
49 palmoplantar keratosis 10.1 KRT5 KRT17 KRT10
50 oncocytic breast carcinoma 10.1 KRT7 KRT14

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma
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Symptoms & Phenotypes for Large Cell Acanthoma

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MGI Mouse Phenotypes related to Large Cell Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 KRT14 KRT17 MLANA TP53
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Drugs & Therapeutics for Large Cell Acanthoma

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Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

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Genetic Tests for Large Cell Acanthoma

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Anatomical Context for Large Cell Acanthoma

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MalaCards organs/tissues related to Large Cell Acanthoma:

40
Breast, Skin, Lung, Uterus, Thymus, Kidney, Liver
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Publications for Large Cell Acanthoma

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Articles related to Large Cell Acanthoma:

(show all 25)
# Title Authors PMID Year
1
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 61
31559241 2019
2
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 61
30940575 2019
3
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 61
29633447 2018
4
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 61
27648388 2016
5
[Anatomoclinical study of large-cell acanthoma]. 61
26651924 2016
6
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. 61
24917472 2014
7
Large cell acanthoma: a debate throughout the decades. 61
24520512 2014
8
Clinical and histopathologic study of benign lichenoid keratosis on the face. 61
23860115 2013
9
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. 61
23786782 2013
10
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. 61
19719831 2010
11
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 61
18845088 2008
12
Large cell acanthoma. 61
12581141 2003
13
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. 61
8030765 1994
14
Large-cell acanthoma is a distinctive condition. 61
1566974 1992
15
Large-cell acanthoma. A distinctive keratosis. 61
1348913 1992
16
Large-cell acanthoma is a solar lentigo. 61
1533104 1992
17
Large-cell acanthoma. 61
1566973 1992
18
Large-cell acanthoma of the eyelid. Report of two cases. 61
1929935 1991
19
Perplexing pigmented papules simulating malignant melanoma. 61
2001637 1991
20
Achromic verrucous large cell acanthoma. 61
2373780 1990
21
Large cell acanthoma. A cytologic variant of Bowen's disease? 61
3232750 1988
22
[Large cell acanthoma]. 61
3537580 1986
23
Multiple large cell acanthomas. 61
6863647 1983
24
[Large cell acanthoma (author's transl)]. 61
7113319 1982
25
Large cell acanthoma. One of the actinic keratoses. 61
619783 1978
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Variations for Large Cell Acanthoma

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Expression for Large Cell Acanthoma

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Search GEO for disease gene expression data for Large Cell Acanthoma.
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Pathways for Large Cell Acanthoma

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Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.06 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
2
Cytoskeletal Signaling 4
12.05 KRT7 KRT5 KRT17 KRT10
3
Estrogen signaling pathway (KEGG) 36
11.72 KRT17 KRT14 KRT10
4
Keratinization 65
Show member pathways
 11.56 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
5
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.49 KRT7 KRT5 KRT17 KRT14
6
Staphylococcus aureus infection 36
11.48 KRT17 KRT14 KRT10
7
Glucocorticoid receptor regulatory network 1
11.17 TP53 KRT5 KRT17 KRT14
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GO Terms for Large Cell Acanthoma

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Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT7 KRT5 KRT14
2 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT17 KRT14 KRT10

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
2 intermediate filament organization GO:0045109 9.26 TCHH KRT17
3 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
4 cornification GO:0070268 9.1 TCHH KRT7 KRT5 KRT17 KRT14 KRT10

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 KRT17 KRT14 KRT10
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Sources for Large Cell Acanthoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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