MCID: LRG002
MIFTS: 26

Large Cell Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Large Cell Acanthoma

MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4321
NCIt 50 C27518
UMLS 73 C1334362

Summaries for Large Cell Acanthoma

MalaCards based summary : Large Cell Acanthoma is related to bowen's disease and papilloma. An important gene associated with Large Cell Acanthoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is integument.

Wikipedia : 76 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

Related Diseases for Large Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 bowen's disease 29.7 KRT10 KRT17 KRT7
2 papilloma 28.5 KRT10 KRT14 KRT5 KRT7
3 steatocystoma multiplex 10.6 KRT10 KRT17
4 hair follicle neoplasm 10.5 KRT14 KRT17
5 pancreatoblastoma 10.5 KRT14 KRT17
6 striate palmoplantar keratoderma 10.5 KRT10 KRT14
7 pachyonychia congenita 1 10.4 KRT10 KRT17
8 keratoacanthoma 10.4 KRT10 KRT17
9 acanthoma 10.4
10 gastric squamous cell carcinoma 10.4 KRT10 KRT5
11 ichthyosis vulgaris 10.4 KRT10 KRT14
12 clear cell basal cell carcinoma 10.4 KRT17 KRT7
13 peritoneum cancer 10.4 KRT5 PTGER4
14 hidradenitis suppurativa 10.4 KRT10 KRT14
15 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
16 hidradenitis 10.4 KRT10 KRT14
17 epidermolysis bullosa simplex, localized 10.4 KRT14 KRT5
18 lichen planopilaris 10.4 KRT14 KRT5
19 pigmented basal cell carcinoma 10.3 KRT14 MLANA
20 epidermolysis bullosa simplex, generalized 10.3 KRT14 KRT5
21 pinguecula 10.3 KRT10 KRT14
22 ampulla of vater neoplasm 10.3 KRT17 KRT7
23 ampulla of vater adenocarcinoma 10.3 KRT17 KRT7
24 odontoma 10.3 KRT14 KRT5
25 cystic basal cell carcinoma 10.3 KRT7 PTGER4
26 anus basaloid carcinoma 10.3 KRT7 PTGER4
27 cervical clear cell adenocarcinoma 10.3 KRT14 KRT5
28 endosalpingiosis 10.3 KRT7 PTGER4
29 vesiculobullous skin disease 10.3 KRT14 KRT5
30 mucinous tubular and spindle renal cell carcinoma 10.3 KRT10 KRT7
31 thymus adenocarcinoma 10.3 KRT7 PTGER4
32 papillary serous adenocarcinoma 10.3 KRT7 PTGER4
33 ovarian mucinous neoplasm 10.3 KRT17 KRT7
34 lipid-rich carcinoma 10.3 KRT14 KRT5
35 sebaceous adenocarcinoma 10.2 KRT5 PTGER4
36 oncocytic breast carcinoma 10.2 KRT14 KRT7
37 spiradenoma 10.2 KRT14 KRT7
38 brooke-spiegler syndrome 10.2 KRT14 KRT7
39 inverted transitional papilloma 10.2 KRT5 KRT7
40 pericardium cancer 10.2 KRT7 PTGER4
41 malignant spiradenoma 10.2 KRT5 KRT7
42 sensory organ benign neoplasm 10.2 KRT5 KRT7
43 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
44 middle ear adenoma 10.1 KRT5 KRT7
45 papillary adenoma 10.1 KRT5 KRT7
46 epithelial-myoepithelial carcinoma 10.1 KRT14 KRT7
47 apocrine adenocarcinoma 10.1 KRT5 KRT7
48 epidermodysplasia verruciformis 10.1 KRT10 KRT14
49 inverted follicular keratosis 10.1 KRT17 MTOR
50 skin benign neoplasm 10.1 KRT14 KRT5

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma

Symptoms & Phenotypes for Large Cell Acanthoma

MGI Mouse Phenotypes related to Large Cell Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 KRT14 KRT17 KRT5 MLANA PTGER4

Drugs & Therapeutics for Large Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

Genetic Tests for Large Cell Acanthoma

Anatomical Context for Large Cell Acanthoma

MalaCards organs/tissues related to Large Cell Acanthoma:

41
Skin

Publications for Large Cell Acanthoma

Articles related to Large Cell Acanthoma:

(show all 16)
# Title Authors Year
1
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
2
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
3
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
4
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
5
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ( 23786782 )
2013
6
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. ( 19719831 )
2010
7
Large cell acanthoma. ( 12581141 )
2003
8
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. ( 8030765 )
1994
9
Large-cell acanthoma is a distinctive condition. ( 1566974 )
1992
10
Large-cell acanthoma. ( 1566973 )
1992
11
Large-cell acanthoma is a solar lentigo. ( 1533104 )
1992
12
Large-cell acanthoma. A distinctive keratosis. ( 1348913 )
1992
13
Large-cell acanthoma of the eyelid. Report of two cases. ( 1929935 )
1991
14
Achromic verrucous large cell acanthoma. ( 2373780 )
1990
15
Large cell acanthoma. A cytologic variant of Bowen's disease? ( 3232750 )
1988
16
Large cell acanthoma. One of the actinic keratoses. ( 619783 )
1978

Variations for Large Cell Acanthoma

Expression for Large Cell Acanthoma

Search GEO for disease gene expression data for Large Cell Acanthoma.

Pathways for Large Cell Acanthoma

Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 KRT10 KRT14 KRT17 KRT5 KRT7
2 11.95 KRT10 KRT17 KRT5 KRT7
3
Show member pathways
11.48 KRT10 KRT14 KRT17 KRT5 KRT7
4 11.35 KRT14 KRT17 KRT5
5
Show member pathways
11.29 KRT14 KRT17 KRT5 KRT7

GO Terms for Large Cell Acanthoma

Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT14 KRT5 KRT7
2 intermediate filament GO:0005882 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT10 KRT14 KRT17 KRT5 KRT7
2 epidermis development GO:0008544 9.33 KRT14 KRT17 KRT5
3 positive regulation of translation GO:0045727 9.32 KRT17 MTOR
4 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
5 cornification GO:0070268 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT10 KRT17 KRT7
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT14 KRT17 KRT5

Sources for Large Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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