MCID: LRG002
MIFTS: 30

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Large Cell Acanthoma

MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4321
NCIt 51 C27518
UMLS 74 C1334362

Summaries for Large Cell Acanthoma

MalaCards based summary : Large Cell Acanthoma is related to acanthoma and bowen's disease. An important gene associated with Large Cell Acanthoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, breast and kidney, and related phenotype is integument.

Wikipedia : 77 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

Related Diseases for Large Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 acanthoma 31.4 KRT10 KRT17
2 bowen's disease 29.9 KRT10 KRT17 KRT7
3 papilloma 29.4 KRT10 KRT14 KRT5 KRT7
4 clear cell acanthoma 10.6
5 eccrine acrospiroma 10.3 KRT10 KRT17
6 steatocystoma multiplex 10.3 KRT10 KRT17
7 striate palmoplantar keratoderma 10.2 KRT10 KRT14
8 keratoacanthoma 10.2 KRT10 KRT17
9 clear cell basal cell carcinoma 10.2 KRT17 KRT7
10 pachyonychia congenita 1 10.2 KRT10 KRT17
11 hidradenitis suppurativa 10.2 KRT10 KRT14
12 lichen planopilaris 10.2 KRT14 KRT5
13 hidradenitis 10.2 KRT10 KRT14
14 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5
15 pigmented basal cell carcinoma 10.2 KRT14 MLANA
16 vulvar intraepithelial neoplasia 10.2 KRT10 KRT7
17 epidermolysis bullosa simplex, localized 10.1 KRT14 KRT5
18 epidermolysis bullosa simplex, generalized 10.1 KRT14 KRT5
19 pinguecula 10.1 KRT10 KRT14
20 cervical clear cell adenocarcinoma 10.1 KRT14 KRT5
21 odontoma 10.1 KRT14 KRT5
22 cystic basal cell carcinoma 10.1 KRT7 PTGER4
23 anus basaloid carcinoma 10.1 KRT7 PTGER4
24 ampulla of vater adenocarcinoma 10.1 KRT17 KRT7
25 malignant syringoma 10.1 KRT7 PTGER4
26 endosalpingiosis 10.1 KRT7 PTGER4
27 palmoplantar keratoderma, epidermolytic 10.1 KRT10 KRT14
28 vesiculobullous skin disease 10.1 KRT14 KRT5
29 breast benign neoplasm 10.1 KRT14 KRT5
30 ovarian mucinous neoplasm 10.1 KRT17 KRT7
31 thoracic benign neoplasm 10.1 KRT14 KRT5
32 lentigines 10.1
33 mucinous tubular and spindle renal cell carcinoma 10.1 KRT10 KRT7
34 thymus adenocarcinoma 10.1 KRT7 PTGER4
35 papillary serous adenocarcinoma 10.1 KRT7 PTGER4
36 spiradenoma 10.1 KRT14 KRT7
37 lipid-rich carcinoma 10.1 KRT14 KRT5
38 oncocytic breast carcinoma 10.1 KRT14 KRT7
39 mucoepidermoid carcinoma 10.1 KRT14 KRT7
40 brooke-spiegler syndrome 10.1 KRT14 KRT7
41 sebaceous adenocarcinoma 10.1 KRT5 PTGER4
42 ampulla of vater cancer 10.1 KRT17 KRT7
43 inverted transitional papilloma 10.1 KRT5 KRT7
44 ceruminoma 10.1 KRT5 KRT7
45 malignant spiradenoma 10.1 KRT5 KRT7
46 sarcomatoid squamous cell skin carcinoma 10.1 KRT5 MLANA
47 pericardium cancer 10.1 KRT7 PTGER4
48 sensory organ benign neoplasm 10.1 KRT5 KRT7
49 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
50 middle ear adenoma 10.1 KRT5 KRT7

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma

Symptoms & Phenotypes for Large Cell Acanthoma

MGI Mouse Phenotypes related to Large Cell Acanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 KRT14 KRT17 KRT5 MLANA PTGER4

Drugs & Therapeutics for Large Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

Genetic Tests for Large Cell Acanthoma

Anatomical Context for Large Cell Acanthoma

MalaCards organs/tissues related to Large Cell Acanthoma:

42
Skin, Breast, Kidney, Thymus, Liver, Prostate, Tonsil

Publications for Large Cell Acanthoma

Articles related to Large Cell Acanthoma:

(show all 17)
# Title Authors Year
1
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. ( 30940575 )
2019
2
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
3
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
4
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
5
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
6
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ( 23786782 )
2013
7
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. ( 19719831 )
2010
8
Large cell acanthoma. ( 12581141 )
2003
9
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. ( 8030765 )
1994
10
Large-cell acanthoma. A distinctive keratosis. ( 1348913 )
1992
11
Large-cell acanthoma is a solar lentigo. ( 1533104 )
1992
12
Large-cell acanthoma. ( 1566973 )
1992
13
Large-cell acanthoma is a distinctive condition. ( 1566974 )
1992
14
Large-cell acanthoma of the eyelid. Report of two cases. ( 1929935 )
1991
15
Achromic verrucous large cell acanthoma. ( 2373780 )
1990
16
Large cell acanthoma. A cytologic variant of Bowen's disease? ( 3232750 )
1988
17
Large cell acanthoma. One of the actinic keratoses. ( 619783 )
1978

Variations for Large Cell Acanthoma

Expression for Large Cell Acanthoma

Search GEO for disease gene expression data for Large Cell Acanthoma.

Pathways for Large Cell Acanthoma

Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 KRT10 KRT14 KRT17 KRT5 KRT7
2 11.95 KRT10 KRT17 KRT5 KRT7
3
Show member pathways
11.48 KRT10 KRT14 KRT17 KRT5 KRT7
4 11.35 KRT14 KRT17 KRT5
5
Show member pathways
11.29 KRT14 KRT17 KRT5 KRT7

GO Terms for Large Cell Acanthoma

Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 KRT10 KRT14 KRT17 KRT5 KRT7
2 cell periphery GO:0071944 9.16 KRT14 KRT17
3 keratin filament GO:0045095 9.13 KRT14 KRT5 KRT7
4 intermediate filament GO:0005882 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT10 KRT14 KRT17 KRT5 KRT7
2 epidermis development GO:0008544 9.33 KRT14 KRT17 KRT5
3 positive regulation of translation GO:0045727 9.32 KRT17 MTOR
4 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
5 cornification GO:0070268 9.02 KRT10 KRT14 KRT17 KRT5 KRT7

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.96 KRT10 KRT17
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT14 KRT17 KRT5

Sources for Large Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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38 KEGG
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46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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