MCID: LRG002
MIFTS: 27

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Large Cell Acanthoma

MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4321
NCIt 49 C27518
SNOMED-CT 68 733894009
UMLS 71 C1334362

Summaries for Large Cell Acanthoma

MalaCards based summary: Large Cell Acanthoma is related to bowen's disease and acanthoma. An important gene associated with Large Cell Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is pigmentation.

Related Diseases for Large Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 bowen's disease 30.7 KRT7 KRT10
2 acanthoma 30.5 TP53 MLANA KRT5 KRT10 CD1B
3 lichen planus 30.1 TP53 KRT10 CD1A
4 actinic keratosis 29.9 TP53 MLANA KRT14 KRT10 BCL2
5 in situ carcinoma 29.5 TP53 KRT7 KRT5 KRT17 KRT14
6 keratosis 29.4 TP53 TCHH KRT5 KRT17 KRT14 KRT10
7 papilloma 29.1 TP53 KRT7 KRT5 KRT14 KRT10 BCL2
8 keratosis, seborrheic 28.4 TP53 MLANA KRT7 KRT5 KRT17 KRT10
9 inverted follicular keratosis 10.4 PTGER4 KRT17
10 pigmented basal cell carcinoma 10.3 PTGER4 MLANA
11 hard palate cancer 10.3 MLANA KRT14
12 sarcomatoid basal cell carcinoma 10.3 PTGER4 KRT5
13 epidermolysis bullosa simplex 1b, generalized intermediate 10.3 KRT5 KRT14
14 adult type testicular granulosa cell tumor 10.3 MLANA KRT5
15 cutaneous leiomyosarcoma 10.3 MLANA KRT5
16 eccrine papillary adenoma 10.3 KRT17 KRT14 KRT10
17 epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive 10.3 KRT5 KRT14
18 proliferative type fibrocystic change of breast 10.3 KRT5 KRT14
19 vulva basal cell carcinoma 10.3 PTGER4 KRT5
20 breast myoepithelial carcinoma 10.3 KRT5 KRT14
21 lipoadenoma 10.3 KRT5 KRT14
22 epidermolysis bullosa simplex generalized type 10.3 KRT5 KRT14
23 epidermolysis bullosa simplex 1c, localized 10.3 KRT5 KRT14
24 follicular infundibulum tumor 10.3 TCHH KRT17
25 breast intraductal proliferative lesion 10.3 KRT5 KRT14
26 lipid-rich carcinoma 10.3 KRT5 KRT14
27 odontoma 10.2 KRT5 KRT14
28 lymphohistiocytoid mesothelioma 10.2 PTGER4 KRT5
29 sarcomatoid squamous cell skin carcinoma 10.2 MLANA KRT5
30 pilar sheath acanthoma 10.2 TCHH ACIN1
31 anal canal paget's disease 10.2 MLANA KRT7
32 anal paget's disease 10.2 MLANA KRT7
33 bartholin's gland adenocarcinoma 10.2 PTGER4 KRT7
34 vulval paget's disease 10.2 MLANA KRT7
35 reticulate acropigmentation of kitamura 10.2 KRT5 KRT14
36 malignant epithelial mesothelioma 10.2 PTGER4 KRT7
37 internal hemorrhoid 10.2 MLANA KRT7
38 oncocytic breast carcinoma 10.2 KRT7 KRT14
39 palmoplantar keratosis 10.2 KRT5 KRT17 KRT10
40 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 KRT10
41 epithelioid type angiomyolipoma 10.2 MLANA KRT7
42 epidermoid cysts 10.2 TCHH KRT17
43 epidermolysis bullosa simplex 1a, generalized severe 10.2 KRT5 KRT14 KRT10
44 ovary leiomyosarcoma 10.2 MLANA BCL2
45 sarcomatoid renal cell carcinoma 10.2 MLANA KRT7
46 squamous papillomatosis 10.2 PTGER4 KRT7
47 laryngeal small cell carcinoma 10.2 MLANA KRT5 KRT14
48 sarcomatoid mesothelioma 10.2 PTGER4 KRT5
49 uterus perivascular epithelioid cell tumor 10.2 MLANA KRT7
50 spiradenoma 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma

Symptoms & Phenotypes for Large Cell Acanthoma

MGI Mouse Phenotypes related to Large Cell Acanthoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 9.02 BCL2 KRT14 KRT17 MLANA TP53

Drugs & Therapeutics for Large Cell Acanthoma

Search Clinical Trials, NIH Clinical Center for Large Cell Acanthoma

Genetic Tests for Large Cell Acanthoma

Anatomical Context for Large Cell Acanthoma

Organs/tissues related to Large Cell Acanthoma:

MalaCards : Skin

Publications for Large Cell Acanthoma

Articles related to Large Cell Acanthoma:

(show all 29)
# Title Authors PMID Year
1
Dermoscopic findings and histopathological correlation in large cell acanthoma. 62
36005944 2022
2
Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study. 62
33946063 2022
3
Variability in the Histopathological Diagnosis of Non-Melanocytic Lesions Excised to Exclude Melanoma. 62
35024222 2021
4
Reflectance confocal findings in a large-cell acanthoma with histologic correlation. 62
34522750 2021
5
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 62
31559241 2019
6
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 62
30940575 2019
7
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 62
29633447 2018
8
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 62
27648388 2016
9
[Anatomoclinical study of large-cell acanthoma]. 62
26651924 2016
10
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. 62
24917472 2014
11
Large cell acanthoma: a debate throughout the decades. 62
24520512 2014
12
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. 62
23786782 2013
13
Clinical and histopathologic study of benign lichenoid keratosis on the face. 62
23860115 2013
14
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. 62
19719831 2010
15
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 62
18845088 2008
16
Large cell acanthoma. 62
12581141 2003
17
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. 62
8030765 1994
18
Large-cell acanthoma is a distinctive condition. 62
1566974 1992
19
Large-cell acanthoma is a solar lentigo. 62
1533104 1992
20
Large-cell acanthoma. A distinctive keratosis. 62
1348913 1992
21
Large-cell acanthoma. 62
1566973 1992
22
Large-cell acanthoma of the eyelid. Report of two cases. 62
1929935 1991
23
Perplexing pigmented papules simulating malignant melanoma. 62
2001637 1991
24
Achromic verrucous large cell acanthoma. 62
2373780 1990
25
Large cell acanthoma. A cytologic variant of Bowen's disease? 62
3232750 1988
26
[Large cell acanthoma]. 62
3537580 1986
27
Multiple large cell acanthomas. 62
6863647 1983
28
[Large cell acanthoma (author's transl)]. 62
7113319 1982
29
Large cell acanthoma. One of the actinic keratoses. 62
619783 1978

Variations for Large Cell Acanthoma

Expression for Large Cell Acanthoma

Search GEO for disease gene expression data for Large Cell Acanthoma.

Pathways for Large Cell Acanthoma

Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 KRT7 KRT5 KRT17 KRT14
2 12.16 KRT7 KRT5 KRT17 KRT10
3
Show member pathways
11.64 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
4 11.58 CD1D CD1C CD1B CD1A
5 11.37 CD1D CD1C CD1A
6 11.14 TP53 KRT5 KRT17 KRT14
7 10.03 TP53 BCL2

GO Terms for Large Cell Acanthoma

Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.81 KRT7 KRT5 KRT17 KRT14 KRT10
2 cornified envelope GO:0001533 9.56 TCHH KRT17 KRT14 KRT10
3 keratin filament GO:0045095 9.32 KRT7 KRT5 KRT17 KRT14 KRT10

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.02 PTGER4 CD1E CD1D CD1C CD1B CD1A
2 intermediate filament organization GO:0045109 9.96 KRT14 KRT17 KRT5 KRT7 TCHH
3 keratinization GO:0031424 9.92 TCHH KRT7 KRT5 KRT17
4 positive regulation of T cell mediated cytotoxicity GO:0001916 9.85 CD1E CD1D CD1C CD1B CD1A
5 B cell lineage commitment GO:0002326 9.71 TP53 BCL2
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.65 CD1E CD1D CD1C CD1B CD1A
7 T cell lineage commitment GO:0002360 9.61 TP53 BCL2
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.32 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.85 CD1E CD1D CD1C CD1B CD1A
2 structural constituent of skin epidermis GO:0030280 9.73 KRT7 KRT5 KRT10
3 exogenous lipid antigen binding GO:0030884 9.65 CD1E CD1D CD1C CD1B CD1A
4 endogenous lipid antigen binding GO:0030883 9.32 CD1E CD1D CD1C CD1B CD1A

Sources for Large Cell Acanthoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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