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MCID: LRG002
MIFTS: 26

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Large Cell Acanthoma

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MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4321
NCIt 50 C27518
UMLS 72 C1334362
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Summaries for Large Cell Acanthoma

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MalaCards based summary : Large Cell Acanthoma is related to acanthoma and inverted follicular keratosis. An important gene associated with Large Cell Acanthoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is integument.

Wikipedia : 75 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

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Related Diseases for Large Cell Acanthoma

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Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 acanthoma 31.8 KRT17 KRT10
2 inverted follicular keratosis 30.7 MTOR KRT17
3 bowen's disease 30.3 KRT7 KRT17 KRT10
4 in situ carcinoma 30.1 KRT5 KRT17 KRT14
5 keratosis, seborrheic 29.5 MTOR KRT5 KRT17 KRT10
6 papilloma 29.3 KRT7 KRT5 KRT14 KRT10
7 clear cell acanthoma 10.6
8 keratosis 10.5
9 eccrine acrospiroma 10.5 KRT17 KRT10
10 steatocystoma multiplex 10.5 KRT17 KRT10
11 lentigines 10.4
12 actinic keratosis 10.4
13 striate palmoplantar keratoderma 10.4 KRT14 KRT10
14 keratoacanthoma 10.3 KRT17 KRT10
15 clear cell basal cell carcinoma 10.3 KRT7 KRT17
16 pachyonychia congenita 1 10.3 KRT17 KRT10
17 hidradenitis 10.3 KRT14 KRT10
18 lichen planopilaris 10.3 KRT5 KRT14
19 hidradenitis suppurativa 10.3 KRT14 KRT10
20 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT5 KRT14
21 vulvar intraepithelial neoplasia 10.2 KRT7 KRT10
22 pigmented basal cell carcinoma 10.2 MLANA KRT14
23 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
24 pinguecula 10.2 KRT14 KRT10
25 epidermolysis bullosa simplex, generalized 10.2 KRT5 KRT14
26 odontoma 10.2 KRT5 KRT14
27 cervical clear cell adenocarcinoma 10.2 KRT5 KRT14
28 anus basaloid carcinoma 10.2 PTGER4 KRT7
29 cystic basal cell carcinoma 10.2 PTGER4 KRT7
30 malignant syringoma 10.2 PTGER4 KRT7
31 ampulla of vater adenocarcinoma 10.2 KRT7 KRT17
32 endosalpingiosis 10.2 PTGER4 KRT7
33 ovarian mucinous neoplasm 10.2 KRT7 KRT17
34 palmoplantar keratoderma, epidermolytic 10.2 KRT14 KRT10
35 vesiculobullous skin disease 10.2 KRT5 KRT14
36 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 KRT10
37 thoracic benign neoplasm 10.2 KRT5 KRT14
38 thymus adenocarcinoma 10.2 PTGER4 KRT7
39 breast benign neoplasm 10.2 KRT5 KRT14
40 papillary serous adenocarcinoma 10.2 PTGER4 KRT7
41 lipid-rich carcinoma 10.2 KRT5 KRT14
42 spiradenoma 10.2 KRT7 KRT14
43 oncocytic breast carcinoma 10.2 KRT7 KRT14
44 mucoepidermoid carcinoma 10.2 KRT7 KRT14
45 sebaceous adenocarcinoma 10.2 PTGER4 KRT5
46 lichen planus 10.1
47 brooke-spiegler syndrome 10.1 KRT7 KRT14
48 inverted transitional papilloma 10.1 KRT7 KRT5
49 ceruminoma 10.1 KRT7 KRT5
50 malignant spiradenoma 10.1 KRT7 KRT5

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma
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Symptoms & Phenotypes for Large Cell Acanthoma

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MGI Mouse Phenotypes related to Large Cell Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 KRT14 KRT17 KRT5 MLANA PTGER4
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Drugs & Therapeutics for Large Cell Acanthoma

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Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

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Genetic Tests for Large Cell Acanthoma

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Anatomical Context for Large Cell Acanthoma

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MalaCards organs/tissues related to Large Cell Acanthoma:

41
Skin
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Publications for Large Cell Acanthoma

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Articles related to Large Cell Acanthoma:

(show all 24)
# Title Authors PMID Year
1
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 38
30940575 2019
2
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 38
29633447 2018
3
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 38
27648388 2016
4
[Anatomoclinical study of large-cell acanthoma]. 38
26651924 2016
5
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. 38
24917472 2014
6
Large cell acanthoma: a debate throughout the decades. 38
24520512 2014
7
Clinical and histopathologic study of benign lichenoid keratosis on the face. 38
23860115 2013
8
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. 38
23786782 2013
9
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. 38
19719831 2010
10
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 38
18845088 2008
11
Large cell acanthoma. 38
12581141 2003
12
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. 38
8030765 1994
13
Large-cell acanthoma is a distinctive condition. 38
1566974 1992
14
Large-cell acanthoma is a solar lentigo. 38
1533104 1992
15
Large-cell acanthoma. A distinctive keratosis. 38
1348913 1992
16
Large-cell acanthoma. 38
1566973 1992
17
Large-cell acanthoma of the eyelid. Report of two cases. 38
1929935 1991
18
Perplexing pigmented papules simulating malignant melanoma. 38
2001637 1991
19
Achromic verrucous large cell acanthoma. 38
2373780 1990
20
Large cell acanthoma. A cytologic variant of Bowen's disease? 38
3232750 1988
21
[Large cell acanthoma]. 38
3537580 1986
22
Multiple large cell acanthomas. 38
6863647 1983
23
[Large cell acanthoma (author's transl)]. 38
7113319 1982
24
Large cell acanthoma. One of the actinic keratoses. 38
619783 1978
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Variations for Large Cell Acanthoma

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Expression for Large Cell Acanthoma

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Search GEO for disease gene expression data for Large Cell Acanthoma.
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Pathways for Large Cell Acanthoma

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Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 12.93 KRT7 KRT5 KRT17 KRT14 KRT10
2
Cytoskeletal Signaling 4
11.95 KRT7 KRT5 KRT17 KRT10
3
Keratinization 66
Show member pathways
 11.48 KRT7 KRT5 KRT17 KRT14 KRT10
4
Glucocorticoid receptor regulatory network 1
11.35 KRT5 KRT17 KRT14
5
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.29 KRT7 KRT5 KRT17 KRT14
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GO Terms for Large Cell Acanthoma

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Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 KRT7 KRT5 KRT17 KRT14 KRT10
2 cell periphery GO:0071944 9.16 KRT17 KRT14
3 keratin filament GO:0045095 9.13 KRT7 KRT5 KRT14
4 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT17 KRT14 KRT10

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT7 KRT5 KRT17 KRT14 KRT10
2 epidermis development GO:0008544 9.33 KRT5 KRT17 KRT14
3 positive regulation of translation GO:0045727 9.32 MTOR KRT17
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 cornification GO:0070268 9.02 KRT7 KRT5 KRT17 KRT14 KRT10

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.96 KRT17 KRT10
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT5 KRT17 KRT14
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Sources for Large Cell Acanthoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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