Large Cell Acanthoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Cell Acanthoma

MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma ¹¹ ¹⁴ ⁷¹

Large-Cell Acanthoma ⁷⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4321

NCIt ⁴⁹ C27518

SNOMED-CT ⁶⁸ 733894009

UMLS ⁷¹ C1334362

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Summaries for Large Cell Acanthoma

MalaCards based summary: Large Cell Acanthoma, also known as large-cell acanthoma, is related to bowen's disease and acanthoma. An important gene associated with Large Cell Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is pigmentation.

Wikipedia: ⁷⁵ Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

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Related Diseases for Large Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)

#	Related Disease	Score	Top Affiliating Genes
1	bowen's disease	30.7	KRT7 KRT10
2	acanthoma	30.5	TP53 MLANA KRT5 KRT10 CD1B
3	lichen planus	30.1	TP53 KRT10 CD1A
4	actinic keratosis	29.9	TP53 MLANA KRT14 KRT10 BCL2
5	keratosis	29.5	TP53 TCHH KRT5 KRT17 KRT14 KRT10
6	papilloma	29.1	TP53 KRT7 KRT5 KRT14 KRT10 BCL2
7	keratosis, seborrheic	28.4	TP53 MLANA KRT7 KRT5 KRT17 KRT10
8	inverted follicular keratosis	10.4	PTGER4 KRT17
9	pigmented basal cell carcinoma	10.3	PTGER4 MLANA
10	hard palate cancer	10.3	MLANA KRT14
11	autosomal dominant generalized epidermolysis bullosa simplex, severe form	10.3	KRT5 KRT14
12	sarcomatoid basal cell carcinoma	10.3	PTGER4 KRT5
13	epidermolysis bullosa simplex 1b, generalized intermediate	10.3	KRT5 KRT14
14	adult type testicular granulosa cell tumor	10.3	MLANA KRT5
15	epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	10.3	KRT5 KRT14
16	cutaneous leiomyosarcoma	10.3	MLANA KRT5
17	eccrine papillary adenoma	10.3	KRT17 KRT14 KRT10
18	proliferative type fibrocystic change of breast	10.3	KRT5 KRT14
19	vulva basal cell carcinoma	10.3	PTGER4 KRT5
20	breast myoepithelial carcinoma	10.3	KRT5 KRT14
21	lipoadenoma	10.3	KRT5 KRT14
22	epidermolysis bullosa simplex generalized type	10.3	KRT5 KRT14
23	epidermolysis bullosa simplex 1c, localized	10.3	KRT5 KRT14
24	follicular infundibulum tumor	10.3	TCHH KRT17
25	breast intraductal proliferative lesion	10.3	KRT5 KRT14
26	lipid-rich carcinoma	10.3	KRT5 KRT14
27	odontoma	10.2	KRT5 KRT14
28	lymphohistiocytoid mesothelioma	10.2	PTGER4 KRT5
29	sarcomatoid squamous cell skin carcinoma	10.2	MLANA KRT5
30	pilar sheath acanthoma	10.2	TCHH ACIN1
31	anal canal paget's disease	10.2	MLANA KRT7
32	anal paget's disease	10.2	MLANA KRT7
33	reticulate acropigmentation of kitamura	10.2	KRT5 KRT14
34	bartholin's gland adenocarcinoma	10.2	PTGER4 KRT7
35	vulval paget's disease	10.2	MLANA KRT7
36	malignant epithelial mesothelioma	10.2	PTGER4 KRT7
37	internal hemorrhoid	10.2	MLANA KRT7
38	oncocytic breast carcinoma	10.2	KRT7 KRT14
39	palmoplantar keratosis	10.2	KRT5 KRT17 KRT10
40	mucinous tubular and spindle renal cell carcinoma	10.2	KRT7 KRT10
41	epithelioid type angiomyolipoma	10.2	MLANA KRT7
42	epidermoid cysts	10.2	TCHH KRT17
43	epidermolysis bullosa simplex 1a, generalized severe	10.2	KRT5 KRT14 KRT10
44	ovary leiomyosarcoma	10.2	MLANA BCL2
45	sarcomatoid renal cell carcinoma	10.2	MLANA KRT7
46	sarcomatoid mesothelioma	10.2	PTGER4 KRT5
47	squamous papillomatosis	10.2	PTGER4 KRT7
48	laryngeal small cell carcinoma	10.2	MLANA KRT5 KRT14
49	uterus perivascular epithelioid cell tumor	10.2	MLANA KRT7
50	intrahepatic gall duct cancer	10.2	KRT7 KRT17

Graphical network of the top 20 diseases related to Large Cell Acanthoma:

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Symptoms & Phenotypes for Large Cell Acanthoma

MGI Mouse Phenotypes related to Large Cell Acanthoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation	MP:0001186	9.02	BCL2 KRT14 KRT17 MLANA TP53

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Drugs & Therapeutics for Large Cell Acanthoma

Search Clinical Trials, NIH Clinical Center for Large Cell Acanthoma

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Genetic Tests for Large Cell Acanthoma

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Anatomical Context for Large Cell Acanthoma

Organs/tissues related to Large Cell Acanthoma:

MalaCards : Skin

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Publications for Large Cell Acanthoma

Articles related to Large Cell Acanthoma:

(show all 29)

#	Title	Authors	PMID	Year
1	Dermoscopic findings and histopathological correlation in large cell acanthoma. ⁶²	Jung JH...Jang MS	36005944	2022
2	Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study. ⁶²	Wang YJ...Wu YH	33946063	2022
3	Variability in the Histopathological Diagnosis of Non-Melanocytic Lesions Excised to Exclude Melanoma. ⁶²	Katz I...Prow T	35024222	2021
4	Reflectance confocal findings in a large-cell acanthoma with histologic correlation. ⁶²	Blumstein AJ...Correa-Selm L	34522750	2021
5	Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. ⁶²	Jakobiec FA...Mandeville J	31559241	2019
6	In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. ⁶²	Wang YJ...Wu YH	30940575	2019
7	Two cases of large cell acanthoma successfully treated with photodynamic therapy. ⁶²	Pindado-Ortega C...Perez-Garcia B	29633447	2018
8	In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ⁶²	Shahriari N...Scope A	27648388	2016
9	[Anatomoclinical study of large-cell acanthoma]. ⁶²	Huther M...Cribier B	26651924	2016
10	Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ⁶²	Fraga GR...Amin SM	24917472	2014
11	Large cell acanthoma: a debate throughout the decades. ⁶²	Patsatsi A...Sotiriadis D	24520512	2014
12	Clinical and histopathologic study of benign lichenoid keratosis on the face. ⁶²	Kim HS...Kim KJ	23860115	2013
13	Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. ⁶²	Jakobiec FA...Colby KA	23786782	2013
14	A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. ⁶²	Ghazi NG...Carter B	19719831	2010
15	Are all seborrheic keratoses benign? Review of the typical lesion and its variants. ⁶²	Noiles K...Vender R	18845088	2008
16	Large cell acanthoma. ⁶²	Mehregan DR...Brown K	12581141	2003
17	Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. ⁶²	Argenyi ZB...Hurt MA	8030765	1994
18	Large-cell acanthoma. A distinctive keratosis. ⁶²	Rabinowitz AD...Inghirami G	1348913	1992
19	Large-cell acanthoma is a solar lentigo. ⁶²	Roewert HJ...Ackerman AB	1533104	1992
20	Large-cell acanthoma is a distinctive condition. ⁶²	Sanchez Yus E...Requena L	1566974	1992
21	Large-cell acanthoma. ⁶²	Weinstock MA	1566973	1992
22	Large-cell acanthoma of the eyelid. Report of two cases. ⁶²	Chevez P...Font RL	1929935	1991
23	Perplexing pigmented papules simulating malignant melanoma. ⁶²	Sherertz EF...White WL	2001637	1991
24	Achromic verrucous large cell acanthoma. ⁶²	Ambrojo P...Sanchez Yus E	2373780	1990
25	Large cell acanthoma. A cytologic variant of Bowen's disease? ⁶²	Sanchez Yus E...Urrutia S	3232750	1988
26	[Large cell acanthoma]. ⁶²	de Souza Sittart JA...Valente NY	3537580	1986
27	Multiple large cell acanthomas. ⁶²	Rabinowitz AD	6863647	1983
28	[Large cell acanthoma (author's transl)]. ⁶²	Scholl W	7113319	1982
29	Large cell acanthoma. One of the actinic keratoses. ⁶²	Rahbari H...Pinkus H	619783	1978

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Genes for Large Cell Acanthoma

Genes related to Large Cell Acanthoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT10	Keratin 10	Protein Coding	5.09	DISEASES inferred ¹⁴
2	KRT17	Keratin 17	Protein Coding	5.06	DISEASES inferred ¹⁴
3	MLANA	Melan-A	Protein Coding	4.79	DISEASES inferred ¹⁴
4	PTGER4	Prostaglandin E Receptor 4	Protein Coding	4.67	DISEASES inferred ¹⁴
5	KRT14	Keratin 14	Protein Coding	4.63	DISEASES inferred ¹⁴
6	ACIN1	Apoptotic Chromatin Condensation Inducer 1	Protein Coding	4.59	DISEASES inferred ¹⁴
7	CD1E	CD1e Molecule	Protein Coding	4.54	DISEASES inferred ¹⁴
8	CD1A	CD1a Molecule	Protein Coding	4.51	DISEASES inferred ¹⁴
9	CD1B	CD1b Molecule	Protein Coding	4.49	DISEASES inferred ¹⁴
10	CD1C	CD1c Molecule	Protein Coding	4.35	DISEASES inferred ¹⁴
11	KRT5	Keratin 5	Protein Coding	4.27	DISEASES inferred ¹⁴
12	CD1D	CD1d Molecule	Protein Coding	4.24	DISEASES inferred ¹⁴
13	TCHH	Trichohyalin	Protein Coding	4.2	DISEASES inferred ¹⁴
14	KRT7	Keratin 7	Protein Coding	4.1	DISEASES inferred ¹⁴
15	PRAME	PRAME Nuclear Receptor Transcriptional Regulator	Protein Coding	3.87	DISEASES inferred ¹⁴
16	TP53	Tumor Protein P53	Protein Coding	3.56	DISEASES inferred ¹⁴
17	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2.97	DISEASES inferred ¹⁴

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Variations for Large Cell Acanthoma

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Expression for Large Cell Acanthoma

Search GEO for disease gene expression data for Large Cell Acanthoma.

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Pathways for Large Cell Acanthoma

Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	COPI-independent Golgi-to-ER retrograde traffic ⁶⁶ Show member pathways Cell cycle Spindle assembly and chromosome separation ²² Cytoskeleton remodeling Keratin filaments ²² Cytoskeleton remodeling Neurofilaments ²² HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ⁶⁶	12.2	KRT7 KRT5 KRT17 KRT14
2	Cytoskeletal Signaling ³	12.16	KRT7 KRT5 KRT17 KRT10
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.64	TCHH KRT7 KRT5 KRT17 KRT14 KRT10
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.58	CD1D CD1C CD1B CD1A
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	CD1D CD1C CD1A
6	Glucocorticoid receptor regulatory network ⁶¹	11.14	TP53 KRT5 KRT17 KRT14
7	MicroRNA network associated with chronic lymphocytic leukemia ⁷⁴	10.03	TP53 BCL2

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GO Terms for Large Cell Acanthoma

Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.81	KRT7 KRT5 KRT17 KRT14 KRT10
2	cornified envelope	GO:0001533	9.56	TCHH KRT17 KRT14 KRT10
3	keratin filament	GO:0045095	9.32	KRT7 KRT5 KRT17 KRT14 KRT10

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.02	PTGER4 CD1E CD1D CD1C CD1B CD1A
2	intermediate filament organization	GO:0045109	9.96	KRT14 KRT17 KRT5 KRT7 TCHH
3	keratinization	GO:0031424	9.92	TCHH KRT7 KRT5 KRT17
4	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.85	CD1E CD1D CD1C CD1B CD1A
5	B cell lineage commitment	GO:0002326	9.71	TP53 BCL2
6	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.65	CD1E CD1D CD1C CD1B CD1A
7	T cell lineage commitment	GO:0002360	9.61	TP53 BCL2
8	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.32	CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.85	CD1E CD1D CD1C CD1B CD1A
2	structural constituent of skin epidermis	GO:0030280	9.73	KRT7 KRT5 KRT10
3	exogenous lipid antigen binding	GO:0030884	9.65	CD1E CD1D CD1C CD1B CD1A
4	endogenous lipid antigen binding	GO:0030883	9.32	CD1E CD1D CD1C CD1B CD1A

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Sources for Large Cell Acanthoma

¹ BitterDB

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³ Cell Signaling Technology

⁴ ClinicalTrials

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⁹ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

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³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

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⁴³ MeSH

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRG002 MIFTS: 29	Large Cell Acanthoma Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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