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MCID: LRG002
MIFTS: 28

Large Cell Acanthoma

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Large Cell Acanthoma

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MalaCards integrated aliases for Large Cell Acanthoma:

Name: Large Cell Acanthoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4321
NCIt 49 C27518
UMLS 71 C1334362
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Summaries for Large Cell Acanthoma

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MalaCards based summary : Large Cell Acanthoma is related to bowen's disease and squamous cell papilloma. An important gene associated with Large Cell Acanthoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include breast, skin and thymus.

Wikipedia : 74 Large-cell acanthomas are a cutaneous condition characterized by small, skin-colored, hyper- or... more...

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Related Diseases for Large Cell Acanthoma

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Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Large Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 bowen's disease 30.9 KRT7 KRT10
2 squamous cell papilloma 30.2 TP53 KRT14
3 keratosis 29.9 TP53 TCHH KRT5 KRT17 KRT10
4 in situ carcinoma 29.8 TP53 KRT5 KRT17 KRT14
5 papilloma 29.3 TP53 KRT7 KRT5 KRT14 KRT10
6 keratosis, seborrheic 29.0 TP53 MTOR MLANA KRT5 KRT17 KRT10
7 clear cell acanthoma 10.7
8 acanthoma 10.7
9 follicular infundibulum tumor 10.5 PTGER4 KRT17
10 steatocystoma multiplex 10.5 KRT17 KRT10
11 lentigines 10.4
12 striate palmoplantar keratoderma 10.4 KRT14 KRT10
13 pinguecula 10.4 KRT14 KRT10
14 sarcomatoid basal cell carcinoma 10.4 PTGER4 KRT5
15 pericardial mesothelioma 10.4 KRT5 KRT10
16 inverted follicular keratosis 10.4
17 actinic keratosis 10.4
18 intrahepatic gall duct cancer 10.4 KRT7 KRT17
19 sarcomatoid squamous cell skin carcinoma 10.4 MLANA KRT5
20 malignant epithelial mesothelioma 10.4 PTGER4 KRT5
21 anal canal paget's disease 10.4 MLANA KRT7
22 anal paget's disease 10.4 MLANA KRT7
23 bartholin's gland adenocarcinoma 10.4 PTGER4 KRT7
24 ovarian wilms' cancer 10.4 MLANA KRT7
25 pregnancy adenoma 10.4 KRT5 KRT14
26 anus basaloid carcinoma 10.3 PTGER4 KRT7
27 jejunal neoplasm 10.3 MLANA KRT7
28 pilar sheath acanthoma 10.3 TCHH MS4A2
29 cardiovascular syphilis 10.3 TCHH MS4A2
30 pulmonary artery leiomyosarcoma 10.3 KRT7 KRT10
31 malignant syringoma 10.3 PTGER4 KRT7
32 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT5 KRT14
33 mucinous tubular and spindle renal cell carcinoma 10.3 KRT7 KRT10
34 odontoma 10.3 KRT5 KRT14
35 oncocytic breast carcinoma 10.3 KRT7 KRT14
36 breast myoepithelial carcinoma 10.3 KRT5 KRT14
37 lipid-rich carcinoma 10.3 KRT5 KRT14
38 inverted transitional papilloma 10.3 KRT7 KRT5
39 ceruminoma 10.3 KRT7 KRT5
40 ureter adenocarcinoma 10.3 KRT7 KRT5
41 lipoadenoma 10.3 KRT7 KRT14
42 subareolar duct papillomatosis 10.3 KRT7 KRT5
43 bone leiomyosarcoma 10.3 KRT7 KRT5
44 nipple neoplasm 10.3 KRT7 KRT5
45 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
46 external ear carcinoma 10.3 KRT7 KRT5
47 epidermoid cysts 10.3 TCHH KRT17
48 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT5
49 middle ear adenoma 10.3 KRT7 KRT5
50 eccrine papillary adenocarcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Large Cell Acanthoma:



Diseases related to Large Cell Acanthoma
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Symptoms & Phenotypes for Large Cell Acanthoma

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Drugs & Therapeutics for Large Cell Acanthoma

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Search Clinical Trials , NIH Clinical Center for Large Cell Acanthoma

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Genetic Tests for Large Cell Acanthoma

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Anatomical Context for Large Cell Acanthoma

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MalaCards organs/tissues related to Large Cell Acanthoma:

40
Breast, Skin, Thymus, Kidney, Uterus, Appendix, Bone
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Publications for Large Cell Acanthoma

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Articles related to Large Cell Acanthoma:

(show all 25)
# Title Authors PMID Year
1
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 61
31559241 2019
2
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 61
30940575 2019
3
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 61
29633447 2018
4
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 61
27648388 2016
5
[Anatomoclinical study of large-cell acanthoma]. 61
26651924 2016
6
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. 61
24917472 2014
7
Large cell acanthoma: a debate throughout the decades. 61
24520512 2014
8
Clinical and histopathologic study of benign lichenoid keratosis on the face. 61
23860115 2013
9
Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. 61
23786782 2013
10
A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. 61
19719831 2010
11
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 61
18845088 2008
12
Large cell acanthoma. 61
12581141 2003
13
Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. 61
8030765 1994
14
Large-cell acanthoma. 61
1566973 1992
15
Large-cell acanthoma is a distinctive condition. 61
1566974 1992
16
Large-cell acanthoma is a solar lentigo. 61
1533104 1992
17
Large-cell acanthoma. A distinctive keratosis. 61
1348913 1992
18
Large-cell acanthoma of the eyelid. Report of two cases. 61
1929935 1991
19
Perplexing pigmented papules simulating malignant melanoma. 61
2001637 1991
20
Achromic verrucous large cell acanthoma. 61
2373780 1990
21
Large cell acanthoma. A cytologic variant of Bowen's disease? 61
3232750 1988
22
[Large cell acanthoma]. 61
3537580 1986
23
Multiple large cell acanthomas. 61
6863647 1983
24
[Large cell acanthoma (author's transl)]. 61
7113319 1982
25
Large cell acanthoma. One of the actinic keratoses. 61
619783 1978
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Variations for Large Cell Acanthoma

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Expression for Large Cell Acanthoma

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Search GEO for disease gene expression data for Large Cell Acanthoma.
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Pathways for Large Cell Acanthoma

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Pathways related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.09 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
2
Relaxin signaling pathway 36
Show member pathways
 12.26 MTOR KRT17 KRT14 KRT10
3
Cytoskeletal Signaling 4
12.05 KRT7 KRT5 KRT17 KRT10
4
Keratinization 65
Show member pathways
 11.56 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
5
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.49 KRT7 KRT5 KRT17 KRT14
6
Staphylococcus aureus infection 36
11.48 KRT17 KRT14 KRT10
7
Glucocorticoid receptor regulatory network 1
11.17 TP53 KRT5 KRT17 KRT14
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GO Terms for Large Cell Acanthoma

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Cellular components related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT7 KRT5 KRT14
2 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT17 KRT14 KRT10

Biological processes related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.43 KRT5 KRT17 KRT14
2 keratinization GO:0031424 9.43 TCHH KRT7 KRT5 KRT17 KRT14 KRT10
3 intermediate filament organization GO:0045109 9.32 TCHH KRT17
4 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
5 cornification GO:0070268 9.1 TCHH KRT7 KRT5 KRT17 KRT14 KRT10

Molecular functions related to Large Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 KRT5 KRT17 KRT14
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Sources for Large Cell Acanthoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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