Large Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRG001 MIFTS: 48	Large Cell Carcinoma Categories: Cancer diseases, Genetic diseases, Respiratory diseases, Skin diseases, Rare diseases
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Aliases & Classifications for Large Cell Carcinoma

MalaCards integrated aliases for Large Cell Carcinoma:

Name: Large Cell Carcinoma ¹² ¹⁵

Carcinoma, Large Cell ⁴⁴ ⁷³

Carcinoma Large Cell ⁵⁵

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases Rare diseases
Anatomical: Respiratory diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4552

MeSH ⁴⁴ D018287

NCIt ⁵⁰ C3780

SNOMED-CT ⁶⁸ 189551005 22687000

UMLS ⁷³ C0206704

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Summaries for Large Cell Carcinoma

Disease Ontology : ¹² A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards based summary : Large Cell Carcinoma, also known as carcinoma, large cell, is related to pleomorphic carcinoma and adenocarcinoma. An important gene associated with Large Cell Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Carboplatin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and thyroid, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Large Cell Carcinoma

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1	Basal Cell Carcinoma 2
Basal Cell Carcinoma 3	Basal Cell Carcinoma 4
Basal Cell Carcinoma 5	Basal Cell Carcinoma 6
Basal Cell Carcinoma 7	Cell Type Cancer
Cell Type Benign Neoplasm	Basal Cell Carcinoma
Large Cell Carcinoma	Basal Cell Carcinoma, Multiple

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)

#	Related Disease	Score	Top Affiliating Genes
1	pleomorphic carcinoma	32.3	EGFR KRT7 NKX2-1
2	adenocarcinoma	30.1	EGFR FGFR1 ROS1 STK11
3	pulmonary large cell neuroendocrine carcinoma	29.2	CHGA ENO2 ROS1 STK11 SYP
4	adenoid cystic carcinoma	29.2	KRT7 NCAM1 TP63
5	lung squamous cell carcinoma	29.1	EGFR FGFR1 PTHLH ROS1 TP63
6	squamous cell carcinoma	29.0	EGFR PTHLH STK11 TP63
7	small cell carcinoma	28.1	CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
8	large cell neuroendocrine carcinoma	28.0	CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
9	adenosquamous carcinoma	27.5	EGFR KRT5 KRT7 NKX2-1 PTHLH TP63
10	lung cancer susceptibility 3	26.6	CEACAM5 EGFR KRT7 NKX2-1 SFTPB STK11
11	lung cancer	23.8	CEACAM5 CHGA EGFR ENO2 FGFR1 KRT7
12	lung large cell carcinoma	12.4
13	large cell carcinoma with rhabdoid phenotype	12.2
14	thymus large cell carcinoma	12.1
15	lung occult large cell carcinoma	12.0
16	lung mixed small cell and squamous cell carcinoma	11.0
17	solid adenocarcinoma with mucin production	10.9	KRT7 NKX2-1
18	adenoma of the pancreas	10.9	CHGA SYP
19	acinar cell cystadenocarcinoma	10.9	CHGA SYP
20	peritoneal serous adenocarcinoma	10.9	CHGA SYP
21	cellular ependymoma	10.9	CHGA SYP
22	primary hepatic neuroendocrine carcinoma	10.9	CHGA SYP
23	ovary neuroendocrine neoplasm	10.9	KRT7 SYP
24	embryoma	10.9	NKX2-1 SYP
25	gastrointestinal neuroendocrine tumor	10.9	CHGA SYP
26	ovarian germ cell teratoma	10.9	KRT7 NKX2-1
27	cystic basal cell carcinoma	10.8	KRT7 TP63
28	lung acinar adenocarcinoma	10.8	KRT7 NKX2-1
29	ovarian germ cell cancer	10.8	KRT7 NKX2-1
30	chordoid meningioma	10.8	CHGA SYP
31	intracranial primitive neuroectodermal tumor	10.8	CHGA ENO2
32	malignant sertoli cell tumor	10.8	ENO2 SYP
33	mucinous bronchioloalveolar adenocarcinoma	10.8	KRT7 NKX2-1
34	transverse colon cancer	10.8	DSC3 KRT7
35	sinonasal undifferentiated carcinoma	10.8	ENO2 SYP
36	lung combined type small cell carcinoma	10.8	NCAM1 SYP
37	pancreatic somatostatinoma	10.8	ENO2 SYP
38	cribriform carcinoma	10.8	KRT7 TP63
39	epithelioid malignant peripheral nerve sheath tumor	10.8	CHGA ENO2
40	papillary tumor of the pineal region	10.8	ENO2 SYP
41	rosette-forming glioneuronal tumor	10.8	FGFR1 SYP
42	sclerosing hepatic carcinoma	10.7	CHGA PTHLH
43	ovarian carcinosarcoma	10.7	ENO2 SYP
44	goblet cell carcinoid	10.7	CHGA ENO2
45	central nervous system primitive neuroectodermal neoplasm	10.7	ENO2 SYP
46	cerebellum cancer	10.7	ENO2 SYP
47	multiple mucosal neuroma	10.7	ENO2 NCAM1
48	subependymal glioma	10.7	ENO2 SYP
49	hypoganglionosis	10.7	NCAM1 SYP
50	renal adenoma	10.7	KRT7 NCAM1

Graphical network of the top 20 diseases related to Large Cell Carcinoma:

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Symptoms & Phenotypes for Large Cell Carcinoma

MGI Mouse Phenotypes related to Large Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.18	KRT5 NCAM1 NKX2-1 ENO2 PTHLH FGFR1
2	cellular	MP:0005384	10.16	PTHLH FGFR1 KRT7 NCAM1 EGFR NKX2-1
3	mortality/aging	MP:0010768	10.06	PTHLH FGFR1 CHGA KRT5 DSC3 NCAM1
4	craniofacial	MP:0005382	9.98	KRT5 EGFR ENO2 PTHLH FGFR1 STK11
5	digestive/alimentary	MP:0005381	9.95	FGFR1 KRT5 EGFR NKX2-1 PTHLH STK11
6	integument	MP:0010771	9.91	PTHLH FGFR1 KRT5 DSC3 EGFR TP63
7	no phenotypic analysis	MP:0003012	9.86	ROS1 KRT5 CHGA EGFR NKX2-1 FGFR1
8	renal/urinary system	MP:0005367	9.7	CHGA KRT7 EGFR PTHLH FGFR1 STK11
9	reproductive system	MP:0005389	9.56	PTHLH FGFR1 CHGA EGFR NKX2-1 TP63
10	respiratory system	MP:0005388	9.17	EGFR NKX2-1 ENO2 PTHLH SFTPB STK11

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Drugs & Therapeutics for Large Cell Carcinoma

Drugs for Large Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Carboplatin

Approved

Phase 4,Phase 3,Phase 2

41575-94-4

10339178 498142 38904

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Everolimus

Approved

Phase 4

159351-69-6

6442177

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

33069-62-4

36314

Sirolimus

Approved, Investigational

Phase 4

53123-88-9

5284616 6436030 46835353

Antimitotic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Albumin-Bound Paclitaxel

Phase 4,Phase 3,Phase 2

Anti-Bacterial Agents

Phase 4

Antibiotics, Antitubercular

Phase 4

Immunosuppressive Agents

Phase 4

Anti-Infective Agents

Phase 4

Antifungal Agents

Phase 4

Antineoplastic Agents, Phytogenic

Phase 4,Phase 3,Phase 2

Crizotinib

Approved

Phase 3,Phase 1

877399-52-5

11626560 10366136 10366137 10366138 10366139 10366140 10366141

Mitogens

Phase 3,Phase 1

Antibodies

Phase 3,Phase 2

Immunoglobulins

Phase 3,Phase 2

Antibodies, Monoclonal

Phase 3,Phase 2

Protein Kinase Inhibitors

Phase 3,Phase 1

insulin

Phase 3

Erlotinib Hydrochloride

Phase 3

183319-69-9

176871

Insulin, Globin Zinc

Phase 3

tyrosine

Nutraceutical

Phase 3,Phase 1

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

5310940 9887054 43805 6857599

Docetaxel

Approved, Investigational

Phase 2,Phase 1

114977-28-5

148124

Etoposide

Approved

Phase 2

33419-42-0

36462

Irinotecan

Approved, Investigational

Phase 2

97682-44-5, 100286-90-6

60838

nivolumab

Approved

Phase 2

946414-94-4

Dacarbazine

Approved, Investigational

Phase 2

4342-03-4

5351166

Temozolomide

Approved, Investigational

Phase 2

85622-93-1

5394

Pemetrexed

Approved, Investigational

Phase 2

150399-23-8, 137281-23-3

446556 60843

leucovorin

Approved, Nutraceutical

Phase 2

58-05-9

143 6006

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

motexafin gadolinium

Investigational

Phase 2,Phase 1

156436-89-4

12047567

Camptothecin

Experimental

Phase 2

7689-03-4

Pharmaceutical Solutions

Phase 2,Phase 1

topoisomerase I inhibitors

Phase 2

Topoisomerase Inhibitors

Phase 2

Dermatologic Agents

Phase 2,Phase 1

Vaccines

Phase 1, Phase 2

Photosensitizing Agents

Phase 2,Phase 1

Etoposide phosphate

Phase 2

Alkylating Agents

Phase 2

Folic Acid Antagonists

Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 2

Vitamin B Complex

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Folate

Nutraceutical

Phase 2

Vitamin B9

Nutraceutical

Phase 2

Cisplatin

Approved

Phase 1

15663-27-1

84093 441203 2767

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly	Completed	NCT02151149	Phase 4	nab-paclitaxel;Carboplatin
2	RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation	Completed	NCT01317615	Phase 4	RAD001;Paclitaxel;Carboplatin
3	ZD6474 (ZACTIMA™) Phase III Study in EGFR Failures	Completed	NCT00404924	Phase 3	ZD6474 (vandetanib)
4	ALTA-1L Study: A Phase 3 Study of Brigatinib Versus Crizotinib in ALK-positive Advanced Non-Small Cell Lung Cancer Patients	Active, not recruiting	NCT02737501	Phase 3	Brigatinib;Xalkori (crizotinib)
5	Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology	Terminated	NCT00596830	Phase 3	CP-751,871 (Figitumumab);Carboplatin;Paclitaxel;Carboplatin;Paclitaxel
6	Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer	Terminated	NCT00673049	Phase 3	CP 751,871 (Figitumumab);Erlotinib;Erlotinib
7	A Phase II Clinical Trial of Docetaxel, Oxaliplatin Combination Chemotherapy in Patients With Stage IIIB/IV Non-adenocarcinoma, Non-small Cell Lung Cancer (NSCLC) as Second-line Treatment	Unknown status	NCT01497041	Phase 2	Docetaxel;Oxaliplatin
8	A Double-blind Study Evaluating IPI-504 and Docetaxel in Patients With Non-Small Cell Lung Cancer	Completed	NCT01362400	Phase 2	IPI 504 plus Docetaxel;Placebo plus Docetaxel
9	Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Small Cell Lung Cancer (SCLC)	Completed	NCT00240097	Phase 2	Intervention A: Irinotecan; Oxaliplatin; Neulasta;Intervention B: Etoposide; Carboplatin; Neulasta
10	Vaccine Treatment for Advanced Non-Small Cell Lung Cancer	Completed	NCT00073398	Phase 1, Phase 2
11	Clinical Trials Comparing Immunotherapy Plus Stereotactic Ablative Radiotherapy (I-SABR) Versus SABR Alone for Stage I, Selected Stage IIa or Isolated Lung Parenchymal Recurrent Non-Small Cell Lung Cancer: I-SABR	Recruiting	NCT03110978	Phase 2	Nivolumab
12	Stereotactic Body Radiotherapy (SBRT) Versus Stereotactic Body Proton Therapy (SBPT)	Terminated	NCT01511081	Phase 2
13	Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer	Terminated	NCT00365183	Phase 2	Motexafin gadolinium and pemetrexed
14	Study of Maintenance Temozolomide Versus Observation in Stable or Responding Stage III/IV Non-Small Cell Lung Cancer Patients (Study P05146)	Terminated	NCT00632203	Phase 2	Temozolomide
15	A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC)	Completed	NCT00102505	Phase 1	Motexafin Gadolinium Injection
16	An Open Label Study of a Peptide Vaccine in Patients With Stage IIb or IIIa Non-Small Cell Lung Cancer	Completed	NCT00054899	Phase 1
17	-02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer	Terminated	NCT01441128	Phase 1	PF-02341066/PF-00299804;PF-02341066/PF-00299804
18	Photodynamic Therapy (PDT) With Temoporfin for Non-Resectable Non-Small-Cell Lung Cancer	Withdrawn	NCT01637376	Phase 1	Temoporfin
19	Use of Social Networking to Survey Women With Small and Large Cell Carcinomas of the Cervix	Recruiting	NCT01606293
20	Mass Spectral Fingerprinting in Lung Cancer	Recruiting	NCT02781857
21	Lung Cancer STARS Trial - STARS Revised Clinical Trial Protocol: Stereotactic Ablative Radiotherapy (SABR) in Stage I Non-small Cell Lung Cancer Patients Who Can Undergo Lobectomy	Active, not recruiting	NCT02357992	Not Applicable
22	An Expanded Access Study of Brigatinib for Patients With ALK-positive Advanced Non-Small Cell Lung Cancer	No longer available	NCT02784158		Brigatinib

Search NIH Clinical Center for Large Cell Carcinoma

Cochrane evidence based reviews: carcinoma, large cell

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Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

MalaCards organs/tissues related to Large Cell Carcinoma:

⁴¹

Lung, Cervix, Thyroid, Ovary, Prostate, Lymph Node, Brain

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Publications for Large Cell Carcinoma

Articles related to Large Cell Carcinoma:

(show top 50) (show all 173)

#	Title	Authors	Year
1	Large Cell Carcinoma with Adenocarcinoma in Lung. ( 29544586 )	Kupeli M....Koseoglu R.D.	2018
2	An Unusually Aggressive Large Cell Carcinoma of the Lung: Undiagnosed until Autopsy. ( 29682432 )	Rajdev K....El-Sayegh D.	2018
3	Clinicopathological and genetic characteristics of pulmonary large cell carcinoma under 2015 WHO classification: a pilot study. ( 29246019 )	Liu R....Chen J.	2017
4	Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. ( 28587298 )	Simon E.J....Boehme K.W.	2017
5	Expression of the CXCR4 ligand SDF-1/CXCL12 is prognostically important for adenocarcinoma and large cell carcinoma of the lung. ( 26818832 )	Sterlacci W....Tzankov A.	2016
6	The development of large-cell carcinoma in the wall of a giant bulla complicated by hemorrhage. ( 26964998 )	Nakamura S....Yokoi K.	2016
7	BRAF mutations in sarcomatoid and large cell carcinoma of the lung. ( 27939777 )	Mengoli M.C....Graziano P.	2016
8	BRAF mutations in sarcomatoid and large cell carcinoma of the lung-reply. ( 27939780 )	Yvorel V....PAcoc'h M.	2016
9	Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung. ( 27384989 )	Lugo R....Alcaraz J.	2016
10	Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria. ( 26430808 )	Driver B.R....Cagle P.T.	2016
11	Prolonged survival with erlotinib followed by afatinib in a caucasian smoker with metastatic, poorly differentiated large cell carcinoma of the lung: a case report. ( 26186355 )	Sala GonzA!lez M.A.8.	2015
12	USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma. ( 25519684 )	Zhao G.Y....Ding J.Y.	2015
13	A retrospective analysis of the clinicopathological characteristics of large cell carcinoma of the lung. ( 25452802 )	Liang R....Wang W.P.	2015
14	Close Relation of Large Cell Carcinoma to Adenocarcinoma by Hierarchical Cluster Analysis: Implications for Histologic Typing of Lung Cancer on Biopsies. ( 25789531 )	Hammer S.H....Prall F.	2015
15	Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )	da Motta L.L....Klamt F.	2015
16	Large cell carcinoma of the lung: a tumor in search of an author. A clinically oriented critical reappraisal. ( 25620799 )	Pelosi G....Papotti M.	2015
17	Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge. ( 26317919 )	Pelosi G....Pastorino U.	2015
18	The BCL11A-XL expression predicts relapse in squamous cell carcinoma and large cell carcinoma. ( 26543611 )	Zhang N....Wu Y.L.	2015
19	Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )	Yoshimoto T....Niki T.	2015
20	Global analysis of chromosome 1 genes among patients with lung adenocarcinoma, squamous carcinoma, large-cell carcinoma, small-cell carcinoma, or non-cancer. ( 25937073 )	Zhang Y....Wang X.	2015
21	Large cell carcinoma of lung: On the verge of extinction? ( 25023633 )	Weissferdt A.	2014
22	Large cell carcinoma on the bullous wall detected in a specimen from a patient with spontaneous pneumothorax: report of a case. ( 25364539 )	Ema T.	2014
23	Large-cell carcinoma of the lung: a diagnostic category redefined by immunohistochemistry and genomics. ( 24811836 )	Sholl L.M.	2014
24	Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. ( 24384807 )	Rekhtman N....Ladanyi M.	2014
25	Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology. ( 24221342 )	Rossi G....Pelosi G.	2014
26	Treatment outcomes of patients with different subtypes of large cell carcinoma of the lung. ( 25085555 )	Sun Y.H....Chen K.J.	2014
27	Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. ( 23696935 )	Terada T.	2013
28	Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma. ( 23738762 )	Hwang D.H....Sholl L.M.	2013
29	Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. ( 23196793 )	Rekhtman N....Ladanyi M.	2013
30	Acute small bowel obstruction: a rare initial presentation for the metastasis of the large-cell carcinoma of the lung. ( 22284720 )	Song Y....Yuan Y.	2012
31	Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung. ( 22420949 )	Lammel V....Simon H.U.	2012
32	Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. ( 23174733 )	Katsenos S....Archondakis S.	2012
33	Rhabdoid large cell carcinoma of lung, with illustrative immunohistochemical and molecular findings. ( 22505007 )	Dettmer M....Cathomas G.	2012
34	Primary undifferentiated large cell carcinoma of the lacrimal gland. ( 21276618 )	Bernardini F.P....Bandelloni R.	2011
35	Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. ( 21847044 )	Nakano T....Takeyoshi I.	2011
36	Large cell carcinoma of the lacrimal gland diagnosed by fine needle aspiration biopsy. ( 22132846 )	Lelli G.J....Yang G.C.	2011
37	Heterogeneity of large cell carcinoma of the lung: an immunophenotypic and miRNA-based analysis. ( 22031317 )	Barbareschi M....Denti M.A.	2011
38	Results of surgical resection for patients with large cell carcinoma of the lung. ( 20547250 )	Hanagiri T....Yasumoto K.	2010
39	Intussusception of small intestine due to metastasis of large cell carcinoma of the lung with a rhabdoid phenotype. ( 20956201 )	Otera H....Ikeda A.	2010
40	Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )	Wang C.Y....Huang M.S.	2010
41	Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )	Su C.C....Chung J.G.	2010
42	Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung. ( 19996214 )	Monica V....Papotti M.	2009
43	Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. ( 19413230 )	Lesniak A....Hodge W.G.	2009
44	Cystic tumors of the right atrium caused by nonbacterial thrombotic endocarditis in a patient with large cell carcinoma. ( 19420823 )	Sakamoto N....Maeda M.	2009
45	Large cell carcinoma of the lung: an endangered species? ( 19444077 )	Pardo J....Lozano M.D.	2009
46	Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung. ( 19287461 )	Monica V....Papotti M.	2009
47	Immunohistochemical characterization of a pulmonary large-cell carcinoma in a dog. ( 18587094 )	Buendia A.J....Navarro J.A.	2008
48	Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas. ( 18364444 )	Zhang H....Xiao X.	2008
49	Lung large cell carcinoma producing granulocyte-colony-stimulating factor. ( 17184692 )	Hasegawa S....Hattori Y.	2007
50	Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. ( 17131342 )	Sugaya M....Yasumoto K.	2007

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Genes for Large Cell Carcinoma

Genes related to Large Cell Carcinoma (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SYP	Synaptophysin	Protein Coding	36.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7671236 9020567 9458138
2	NKX2-1	NK2 Homeobox 1	Protein Coding	32.54	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18227018 10374779 17062341 (more) 10632746 15494931 12379752 14693848 11956814 10792482 15595193 15722794
3	CHGA	Chromogranin A	Protein Coding	30.75	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9458138 1315401 19233580 (more) 2170973
4	ENO2	Enolase 2	Protein Coding	29.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1702634 10622207 7507359 (more) 9458138 18404793 1331003 7523546
5	TP63	Tumor Protein P63	Protein Coding	29.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16540737 11956814 15551738 (more) 12210069 14612504
6	KRT7	Keratin 7	Protein Coding	28.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15595193 15494931 19859629
7	EGFR	Epidermal Growth Factor Receptor	Protein Coding	21.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	16552419 17192868 17721266 (more) 16284218 18452692 15681531 12867060 17069674 14679115
8	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
9	DSC3	Desmocollin 3	Protein Coding	21.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	21.24	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
11	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	21.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	20.83	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17669716 1935781
13	KRT5	Keratin 5	Protein Coding	20.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	15494931 12548160
14	SFTPB	Surfactant Protein B	Protein Coding	20.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	9021728
15	STK11	Serine/Threonine Kinase 11	Protein Coding	20.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	11.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8168034

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Variations for Large Cell Carcinoma

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Expression for Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

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Pathways for Large Cell Carcinoma

Pathways related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	12.09	ENO2 NCAM1 NKX2-1 SYP
2	L1CAM interactions ⁶⁶ Show member pathways CHL1 interactions ⁶⁶ Neurofascin interactions ⁶⁶ NrCAM interactions ⁶⁶	11.59	EGFR FGFR1 NCAM1
3	Parathyroid hormone synthesis, secretion and action ³⁷	11.36	EGFR FGFR1 PTHLH
4	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.03	FGFR1 NCAM1 SYP
5	Signal transduction by L1 ⁶⁶	10.12	EGFR FGFR1 NCAM1

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GO Terms for Large Cell Carcinoma

Cellular components related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.23	CEACAM5 CHGA DSC3 EGFR FGFR1 NCAM1

Biological processes related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.72	CEACAM5 EGFR FGFR1 ROS1 TP63
2	animal organ morphogenesis	GO:0009887	9.65	NKX2-1 SFTPB TP63
3	negative regulation of signal transduction	GO:0009968	9.63	EGFR FGFR1 ROS1
4	cornification	GO:0070268	9.61	DSC3 KRT5 KRT7
5	lung development	GO:0030324	9.58	EGFR FGFR1 NKX2-1
6	cerebral cortex cell migration	GO:0021795	9.37	EGFR NKX2-1
7	positive regulation of kinase activity	GO:0033674	9.33	EGFR FGFR1 ROS1
8	salivary gland morphogenesis	GO:0007435	9.26	EGFR FGFR1
9	regulation of phosphate transport	GO:0010966	8.96	FGFR1 ROS1
10	epidermis development	GO:0008544	8.92	EGFR KRT5 PTHLH TP63

Molecular functions related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.43	EGFR FGFR1 NCAM1
2	MAP kinase kinase kinase activity	GO:0004709	9.33	EGFR FGFR1 ROS1
3	mitogen-activated protein kinase kinase binding	GO:0031434	9.13	EGFR FGFR1 ROS1
4	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.8	EGFR FGFR1 ROS1

Sources

Sources for Large Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia