Large Cell Carcinoma with Rhabdoid Phenotype disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards integrated aliases for Large Cell Carcinoma with Rhabdoid Phenotype:

Name: Large Cell Carcinoma with Rhabdoid Phenotype ¹¹ ¹⁴

Large Cell Lung Carcinoma with Rhabdoid Phenotype ¹¹

Large-Cell Lung Carcinoma with Rhabdoid Phenotype ⁷⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7480

NCIt ⁴⁹ C6876

SNOMED-CT ⁶⁸ 128629005

UMLS ⁷¹ C1265997

Sources

Summaries for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards based summary: Large Cell Carcinoma with Rhabdoid Phenotype, also known as large cell lung carcinoma with rhabdoid phenotype, is related to large cell carcinoma and lung large cell carcinoma. An important gene associated with Large Cell Carcinoma with Rhabdoid Phenotype is CHL1 (Cell Adhesion Molecule L1 Like), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Endometrial cancer. Affiliated tissues include lung and skeletal muscle, and related phenotypes are Increased Nanog expression and Increased proliferation

Wikipedia: ⁷⁵ Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer,... more...

Sources

Related Diseases for Large Cell Carcinoma with Rhabdoid Phenotype

Diseases related to Large Cell Carcinoma with Rhabdoid Phenotype via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)

#	Related Disease	Score	Top Affiliating Genes
1	large cell carcinoma	30.2	TP53 KRAS HRAS ENO2
2	lung large cell carcinoma	29.9	TP53 KRAS HRAS ENO2 CHL1
3	pacinian tumor	10.3	ENO2 CALB2
4	breast granular cell tumor	10.3	ENO2 CALB2
5	spindle cell thymoma	10.3	ENO2 CALB2
6	peritoneal serous adenocarcinoma	10.3	CLDN4 CALB2
7	basan syndrome	10.3	SMARCA4 SMARCA2
8	gallbladder small cell carcinoma	10.3	ENO2 CHL1
9	mediastinum sarcoma	10.3	SMARCA4 CALB2
10	lung sarcoma	10.3	MYOG CALB2
11	lymphohistiocytoid mesothelioma	10.3	CLDN4 CALB2
12	pulmonary neuroendocrine tumor	10.3	ENO2 CHL1
13	malignant glandular tumor of peripheral nerve sheath	10.3	MYOG CALB2
14	cervical carcinosarcoma	10.3	MYOG CALB2
15	central nervous system mesenchymal non-meningothelial tumor	10.3	MYOG ENO2
16	ectomesenchymoma	10.3	MYOG ENO2
17	endobronchial leiomyoma	10.3	MYOG ENO2
18	scrotum neoplasm	10.3	MYOG CALB2
19	malignant triton tumor	10.2	MYOG ENO2
20	mediastinal cancer	10.2	ENO2 CALB2
21	askin's tumor	10.2	MYOG ENO2
22	neurohypophysis granular cell tumor	10.2	ENO2 CHL1 CALB2
23	monophasic synovial sarcoma	10.2	MYOG CALB2
24	posterior pituitary gland neoplasm	10.2	SMARCB1 SMARCA4
25	central nervous system melanocytic neoplasm	10.2	HRAS ENO2
26	optic nerve astrocytoma	10.2	SMARCB1 ENO2
27	sarcomatoid mesothelioma	10.2	CLDN4 CALB2
28	heart sarcoma	10.2	MYOG CALB2
29	plexiform schwannoma	10.2	SMARCB1 ENO2
30	extraosseous ewing sarcoma	10.2	MYOG ENO2
31	schizophrenia 12	10.2	SMARCA2 CALB2
32	trachea carcinoma in situ	10.2	KRAS HRAS
33	fallopian tube endometrioid adenocarcinoma	10.2	MYOG CALB2
34	lung cancer	10.2
35	common bile duct neoplasm	10.2	KRAS HRAS
36	clear cell cystadenofibroma	10.2	TP53 CALB2
37	bladder urachal carcinoma	10.2	KRAS HRAS
38	hepatic flexure cancer	10.2	KRAS HRAS
39	urachus cancer	10.2	KRAS HRAS
40	adenosquamous lung carcinoma	10.2	KRAS HRAS
41	descending colon cancer	10.2	KRAS HRAS
42	sigmoid neoplasm	10.2	KRAS HRAS
43	appendiceal neoplasm	10.2	KRAS HRAS
44	biphasic synovial sarcoma	10.2	SMARCB1 CALB2
45	acneiform dermatitis	10.2	KRAS HRAS
46	transverse colon cancer	10.2	KRAS HRAS
47	fallopian tube carcinosarcoma	10.2	TP53 CALB2
48	noonan syndrome-like disorder with loose anagen hair 1	10.2	KRAS HRAS
49	ascending colon cancer	10.2	KRAS HRAS
50	frontal lobe neoplasm	10.2	TP53 ENO2

Graphical network of the top 20 diseases related to Large Cell Carcinoma with Rhabdoid Phenotype:

Sources

Symptoms & Phenotypes for Large Cell Carcinoma with Rhabdoid Phenotype

GenomeRNAi Phenotypes related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased Nanog expression	GR00371-A-1	9.23	BANF1 SMARCA4 SMARCB1 VEGFA
2	Increased Nanog expression	GR00371-A-2	9.23	VEGFA
3	Increased Nanog expression	GR00371-A-4	9.23	VEGFA
4	Increased Nanog expression	GR00371-A-5	9.23	BANF1 VEGFA
5	Increased proliferation	GR00094-A	8.96	SMARCB1 TP53

MGI Mouse Phenotypes related to Large Cell Carcinoma with Rhabdoid Phenotype:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.15	CHL1 CLDN4 ENO2 HRAS KEAP1 KRAS
2	normal	MP:0002873	10.06	CALB2 CLDN4 HRAS KRAS MYOG SMARCA4
3	neoplasm	MP:0002006	10.02	HRAS KRAS SMARCA2 SMARCA4 SMARCB1 TP53
4	muscle	MP:0005369	10.01	HRAS KRAS MYOG SMARCA2 SMARCA4 SMARCB1
5	renal/urinary system	MP:0005367	9.98	CLDN4 HRAS KRAS SMARCA2 SMARCA4 TP53
6	digestive/alimentary	MP:0005381	9.97	HRAS KEAP1 KRAS MUC5AC SMARCA2 SMARCA4
7	behavior/neurological	MP:0005386	9.93	CALB2 CHL1 CLDN4 ENO2 HRAS KRAS
8	craniofacial	MP:0005382	9.8	CHL1 ENO2 HRAS KRAS SMARCA4 TP53
9	respiratory system	MP:0005388	9.61	CHL1 ENO2 HRAS KEAP1 KRAS MYOG
10	integument	MP:0010771	9.28	HRAS KEAP1 KRAS MYOG SMARCA2 SMARCA4

Sources

Drugs & Therapeutics for Large Cell Carcinoma with Rhabdoid Phenotype

Search Clinical Trials, NIH Clinical Center for Large Cell Carcinoma with Rhabdoid Phenotype

Sources

Genetic Tests for Large Cell Carcinoma with Rhabdoid Phenotype

Sources

Anatomical Context for Large Cell Carcinoma with Rhabdoid Phenotype

Organs/tissues related to Large Cell Carcinoma with Rhabdoid Phenotype:

MalaCards : Lung, Skeletal Muscle

Sources

Publications for Large Cell Carcinoma with Rhabdoid Phenotype

Articles related to Large Cell Carcinoma with Rhabdoid Phenotype:

#	Title	Authors	PMID	Year
1	[A clinical review of 3 cases of children with bronchial tumor]. ⁶²	Wang Y...Han F	26696483	2015
2	Large cell lung carcinoma with rhabdoid phenotype: Report of a rare entity presenting with chest wall involvement. ⁶²	Bahadur S...Raina PK	26458655	2015
3	Large cell carcinoma of lung: On the verge of extinction? ⁶²	Weissferdt A	25023633	2014
4	Pulmonary large cell carcinoma with rhabdoid phenotype. ⁶²	Yilmazbayhan D...Kalayci G	16084457	2005
5	Pulmonary large cell carcinoma with rhabdoid phenotype. ⁶²	Hiroshima K...Fujisawa T	12554537	2003

Sources

Genes for Large Cell Carcinoma with Rhabdoid Phenotype

Genes related to Large Cell Carcinoma with Rhabdoid Phenotype (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CHL1	Cell Adhesion Molecule L1 Like	Protein Coding	4.9	DISEASES inferred ¹⁴
2	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	4.84	DISEASES inferred ¹⁴
3	ENO2	Enolase 2	Protein Coding	4.5	DISEASES inferred ¹⁴
4	CALB2	Calbindin 2	Protein Coding	4.17	DISEASES inferred ¹⁴
5	SMARCA2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2	Protein Coding	3.67	DISEASES inferred ¹⁴
6	CLDN4	Claudin 4	Protein Coding	3.67	DISEASES inferred ¹⁴
7	BANF1	BAF Nuclear Assembly Factor 1	Protein Coding	3.62	DISEASES inferred ¹⁴
8	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3.38	DISEASES inferred ¹⁴
9	MYOG	Myogenin	Protein Coding	3.34	DISEASES inferred ¹⁴
10	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3.25	DISEASES inferred ¹⁴
11	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	3.25	DISEASES inferred ¹⁴
12	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	3.24	DISEASES inferred ¹⁴
13	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	2.98	DISEASES inferred ¹⁴
14	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	2.89	DISEASES inferred ¹⁴
15	TP53	Tumor Protein P53	Protein Coding	2.78	DISEASES inferred ¹⁴

Sources

Variations for Large Cell Carcinoma with Rhabdoid Phenotype

Sources

Expression for Large Cell Carcinoma with Rhabdoid Phenotype

Search GEO for disease gene expression data for Large Cell Carcinoma with Rhabdoid Phenotype.

Sources

Pathways for Large Cell Carcinoma with Rhabdoid Phenotype

Pathways related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

(show all 23)

#	Super pathways	Score	Top Affiliating Genes
1	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.45	VEGFA TP53 SMARCB1 SMARCA4 SMARCA2 KRAS
2	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.53	VEGFA TP53 KRAS HRAS
3	Epithelial to mesenchymal transition in colorectal cancer ⁷⁴	12	CLDN4 HRAS KRAS TP53
4	Integrated breast cancer pathway ⁷⁴	11.94	VEGFA TP53 SMARCA4 KRAS
5	Gastrin signaling pathway ⁷⁴	11.8	VEGFA KRAS HRAS
6	DNA damage response (only ATM dependent) ⁷⁴	11.74	TP53 KRAS HRAS
7	mTOR Pathway ⁷⁰ Show member pathways TGF-beta Pathway ⁷⁰	11.61	TP53 KRAS HRAS
8	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.54	TP53 SMARCB1 SMARCA4 SMARCA2
9	Pathways affected in adenoid cystic carcinoma ⁷⁴	11.49	TP53 SMARCA2 HRAS
10	Thermogenesis ⁷⁴ Show member pathways mitochondrial L-carnitine shuttle ⁶¹	11.41	SMARCB1 SMARCA4 SMARCA2 KRAS HRAS
11	Transcription Ligand-dependent activation of the ESR1/SP pathway ²² Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²²	11.4	VEGFA SMARCB1 SMARCA4 SMARCA2
12	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.32	VEGFA KRAS HRAS
13	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ⁶⁶	11.23	SMARCB1 SMARCA4 SMARCA2
14	Envelope proteins and their potential roles in EDMD physiopathology ⁷⁴	11.17	KRAS HRAS BANF1
15	Transcription_Transcription factor Tubby signaling pathways ²²	11.16	TP53 KRAS HRAS
16	Aryl hydrocarbon receptor pathway ⁷⁴	11.06	VEGFA KRAS HRAS
17	Bladder cancer ⁷⁴	11.06	VEGFA TP53 KRAS HRAS
18	Hypertrophy model ⁷⁴	10.91	VEGFA MYOG
19	Head and neck squamous cell carcinoma ⁷⁴	10.88	VEGFA TP53 KRAS KEAP1 HRAS
20	VEGFR2 mediated cell proliferation ⁶⁶	10.87	VEGFA KRAS HRAS
21	Validated nuclear estrogen receptor beta network ⁶¹	10.77	SMARCB1 SMARCA4
22	Quercetin and Nf-kB / AP-1 induced apoptosis ⁷⁴	10.76	VEGFA KEAP1
23	TNF-alpha signaling pathway ⁷⁴ Show member pathways RAS GTPase cycle mutants ⁶⁶ Signaling by RAS GAP mutants ⁶⁶ Signaling by RAS GTPase mutants ⁶⁶	10.63	KRAS HRAS

Sources

GO Terms for Large Cell Carcinoma with Rhabdoid Phenotype

Cellular components related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	SWI/SNF complex	GO:0016514	9.88	SMARCB1 SMARCA4 SMARCA2
2	nBAF complex	GO:0071565	9.8	SMARCB1 SMARCA4 SMARCA2
3	npBAF complex	GO:0071564	9.73	SMARCB1 SMARCA4 SMARCA2
4	germ cell nucleus	GO:0043073	9.67	TP53 SMARCB1
5	bBAF complex	GO:0140092	9.63	SMARCB1 SMARCA4 SMARCA2
6	DNA packaging complex	GO:0044815	9.13	SMARCB1 SMARCA4 SMARCA2
7	SWI/SNF superfamily-type complex	GO:0070603	8.8	SMARCB1 SMARCA4 SMARCA2

Biological processes related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.21	TP53 SMARCB1 SMARCA2 MYOG HRAS
2	positive regulation of cell differentiation	GO:0045597	9.97	SMARCB1 SMARCA4 SMARCA2
3	regulation of G1/S transition of mitotic cell cycle	GO:2000045	9.95	SMARCB1 SMARCA4 SMARCA2
4	positive regulation of stem cell population maintenance	GO:1902459	9.93	SMARCB1 SMARCA4 SMARCA2
5	positive regulation of double-strand break repair	GO:2000781	9.88	SMARCA2 SMARCA4 SMARCB1
6	positive regulation of T cell differentiation	GO:0045582	9.85	SMARCB1 SMARCA4 SMARCA2
7	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	9.83	SMARCB1 SMARCA4
8	regulation of mitotic metaphase/anaphase transition	GO:0030071	9.8	SMARCB1 SMARCA4 SMARCA2
9	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.73	VEGFA TP53
10	regulation of nucleotide-excision repair	GO:2000819	9.63	SMARCB1 SMARCA4 SMARCA2
11	positive regulation of glucose mediated signaling pathway	GO:1902661	9.56	SMARCB1 SMARCA4
12	regulation of G0 to G1 transition	GO:0070316	9.43	SMARCB1 SMARCA4 SMARCA2
13	positive regulation of myoblast differentiation	GO:0045663	9.23	SMARCB1 SMARCA4 SMARCA2 MYOG

Molecular functions related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Tat protein binding	GO:0030957	9.46	SMARCB1 SMARCA4
2	p53 binding	GO:0002039	9.43	TP53 SMARCB1 SMARCA4
3	RNA polymerase I core promoter sequence-specific DNA binding	GO:0001164	8.92	SMARCB1 SMARCA4

Sources

Sources for Large Cell Carcinoma with Rhabdoid Phenotype

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRG005 MIFTS: 31	Large Cell Carcinoma with Rhabdoid Phenotype Categories: Cancer diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Expand all tables