Large Cell Carcinoma with Rhabdoid Phenotype disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards integrated aliases for Large Cell Carcinoma with Rhabdoid Phenotype:

Name: Large Cell Carcinoma with Rhabdoid Phenotype ¹² ¹⁵

Large Cell Lung Carcinoma with Rhabdoid Phenotype ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7480

NCIt ⁵⁰ C6876

SNOMED-CT ⁶⁷ 128629005

UMLS ⁷⁰ C1265997

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Summaries for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards based summary : Large Cell Carcinoma with Rhabdoid Phenotype, also known as large cell lung carcinoma with rhabdoid phenotype, is related to large cell carcinoma and lung large cell carcinoma. An important gene associated with Large Cell Carcinoma with Rhabdoid Phenotype is CHL1 (Cell Adhesion Molecule L1 Like), and among its related pathways/superpathways are HIF-1 signaling pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include lung and skeletal muscle, and related phenotypes are behavior/neurological and nervous system

Wikipedia : ⁷³ Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer,... more...

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Related Diseases for Large Cell Carcinoma with Rhabdoid Phenotype

Diseases related to Large Cell Carcinoma with Rhabdoid Phenotype via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)

#	Related Disease	Score	Top Affiliating Genes
1	large cell carcinoma	10.3
2	lung large cell carcinoma	10.2
3	ovarian large-cell neuroendocrine carcinoma	10.1	ENO2 CHL1
4	colon neuroendocrine neoplasm	10.1	ENO2 CHL1
5	retroperitoneal hemangiopericytoma	10.1	VEGFA ENO2
6	cancer-associated retinopathy	10.1	VEGFA ENO2
7	carcinoid syndrome	10.1	VEGFA ENO2
8	leiomyosarcoma	10.1	VEGFA ENO2
9	tuberculous meningitis	10.1	VEGFA ENO2
10	acute mountain sickness	10.1	VEGFA ENO2
11	optic nerve astrocytoma	10.0	SMARCB1 ENO2
12	pineal region teratoma	10.0	SMARCB1 ENO2
13	plexiform schwannoma	10.0	SMARCB1 ENO2
14	kidney rhabdoid cancer	10.0	SMARCB1 ENO2
15	coats disease	10.0	VEGFA ENO2
16	rhabdoid meningioma	10.0	SMARCB1 ENO2
17	cerebrovascular benign neoplasm	10.0	SMARCB1 ENO2
18	olfactory nerve neoplasm	10.0	SMARCB1 ENO2
19	cranial nerve malignant neoplasm	10.0	SMARCB1 ENO2
20	pineal gland cancer	10.0	SMARCB1 ENO2
21	central nervous system primitive neuroectodermal neoplasm	10.0	SMARCB1 ENO2
22	cranial nerve neoplasm	10.0	SMARCB1 ENO2
23	ependymoblastoma	10.0	SMARCB1 ENO2
24	extraosseous chondrosarcoma	10.0	SMARCB1 ENO2
25	spinal cancer	10.0	SMARCB1 ENO2
26	cerebral ventricle cancer	10.0	SMARCB1 ENO2
27	t-cell prolymphocytic leukemia	10.0	VEGFA SMARCB1
28	cerebrum cancer	10.0	SMARCB1 ENO2
29	supratentorial cancer	10.0	SMARCB1 ENO2
30	papilloma of choroid plexus	10.0	SMARCB1 ENO2
31	cardiovascular organ benign neoplasm	10.0	VEGFA ENO2
32	mesenchymal chondrosarcoma	10.0	SMARCB1 ENO2
33	secondary progressive multiple sclerosis	10.0	VEGFA ENO2
34	hemangioblastoma	10.0	VEGFA ENO2
35	chondrosarcoma, extraskeletal myxoid	10.0	SMARCB1 ENO2
36	ganglioglioma	9.9	SMARCB1 ENO2
37	skeletal muscle cancer	9.9	SMARCB1 ENO2
38	muscle cancer	9.9	SMARCB1 ENO2
39	neuroendocrine tumor	9.9	VEGFA ENO2
40	neuroma	9.9	SMARCB1 ENO2
41	pacinian tumor	9.9	ENO2 CALB2
42	spindle cell thymoma	9.9	ENO2 CALB2
43	thymoma	9.9	VEGFA CALB2
44	myoblastoma	9.9	ENO2 CALB2
45	mucinous stomach adenocarcinoma	9.9	VEGFA CALB2
46	epithelioid hemangioendothelioma	9.9	VEGFA CALB2
47	liver leiomyosarcoma	9.9	ENO2 CALB2
48	autonomic nervous system neoplasm	9.9	VEGFA ENO2
49	pulmonary sclerosing hemangioma	9.9	ENO2 CALB2
50	chordoma	9.9	VEGFA SMARCB1

Graphical network of the top 20 diseases related to Large Cell Carcinoma with Rhabdoid Phenotype:

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Symptoms & Phenotypes for Large Cell Carcinoma with Rhabdoid Phenotype

MGI Mouse Phenotypes related to Large Cell Carcinoma with Rhabdoid Phenotype:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.35	CALB2 CHL1 ENO2 SMARCB1 VEGFA
2	nervous system	MP:0003631	9.02	CALB2 CHL1 ENO2 SMARCB1 VEGFA

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Drugs & Therapeutics for Large Cell Carcinoma with Rhabdoid Phenotype

Search Clinical Trials , NIH Clinical Center for Large Cell Carcinoma with Rhabdoid Phenotype

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Genetic Tests for Large Cell Carcinoma with Rhabdoid Phenotype

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Anatomical Context for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards organs/tissues related to Large Cell Carcinoma with Rhabdoid Phenotype:

⁴⁰

Lung, Skeletal Muscle

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Publications for Large Cell Carcinoma with Rhabdoid Phenotype

Articles related to Large Cell Carcinoma with Rhabdoid Phenotype:

#	Title	Authors	PMID	Year
1	[A clinical review of 3 cases of children with bronchial tumor]. ⁶¹	Wang Y...Han F	26696483	2015
2	Large cell lung carcinoma with rhabdoid phenotype: Report of a rare entity presenting with chest wall involvement. ⁶¹	Bahadur S...Raina PK	26458655	2015
3	Large cell carcinoma of lung: On the verge of extinction? ⁶¹	Weissferdt A	25023633	2014
4	Pulmonary large cell carcinoma with rhabdoid phenotype. ⁶¹	Yilmazbayhan D...Kalayci G	16084457	2005
5	Pulmonary large cell carcinoma with rhabdoid phenotype. ⁶¹	Hiroshima K...Fujisawa T	12554537	2003

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Genes for Large Cell Carcinoma with Rhabdoid Phenotype

Genes related to Large Cell Carcinoma with Rhabdoid Phenotype (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CHL1	Cell Adhesion Molecule L1 Like	Protein Coding	5.81	DISEASES inferred ¹⁵
2	ENO2	Enolase 2	Protein Coding	5.42	DISEASES inferred ¹⁵
3	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.28	DISEASES inferred ¹⁵
4	CALB2	Calbindin 2	Protein Coding	4.28	DISEASES inferred ¹⁵
5	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	4.01	DISEASES inferred ¹⁵

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Variations for Large Cell Carcinoma with Rhabdoid Phenotype

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Expression for Large Cell Carcinoma with Rhabdoid Phenotype

Search GEO for disease gene expression data for Large Cell Carcinoma with Rhabdoid Phenotype.

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Pathways for Large Cell Carcinoma with Rhabdoid Phenotype

Pathways related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	HIF-1 signaling pathway ³⁶	10.99	VEGFA ENO2
2	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	10.47	VEGFA SMARCB1

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GO Terms for Large Cell Carcinoma with Rhabdoid Phenotype

Biological processes related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	8.8	VEGFA SMARCB1 CHL1

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