MCID: LRG005
MIFTS: 31

Large Cell Carcinoma with Rhabdoid Phenotype

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards integrated aliases for Large Cell Carcinoma with Rhabdoid Phenotype:

Name: Large Cell Carcinoma with Rhabdoid Phenotype 11 14
Large Cell Lung Carcinoma with Rhabdoid Phenotype 11
Large-Cell Lung Carcinoma with Rhabdoid Phenotype 75

Classifications:



External Ids:

Disease Ontology 11 DOID:7480
NCIt 49 C6876
SNOMED-CT 68 128629005
UMLS 71 C1265997

Summaries for Large Cell Carcinoma with Rhabdoid Phenotype

MalaCards based summary: Large Cell Carcinoma with Rhabdoid Phenotype, also known as large cell lung carcinoma with rhabdoid phenotype, is related to large cell carcinoma and lung large cell carcinoma. An important gene associated with Large Cell Carcinoma with Rhabdoid Phenotype is CHL1 (Cell Adhesion Molecule L1 Like), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Endometrial cancer. Affiliated tissues include lung and skeletal muscle, and related phenotypes are Increased Nanog expression and Increased proliferation

Wikipedia: 75 Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer,... more...

Related Diseases for Large Cell Carcinoma with Rhabdoid Phenotype

Diseases related to Large Cell Carcinoma with Rhabdoid Phenotype via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 large cell carcinoma 30.2 TP53 KRAS HRAS ENO2
2 lung large cell carcinoma 29.9 TP53 KRAS HRAS ENO2 CHL1
3 pacinian tumor 10.3 ENO2 CALB2
4 breast granular cell tumor 10.3 ENO2 CALB2
5 spindle cell thymoma 10.3 ENO2 CALB2
6 peritoneal serous adenocarcinoma 10.3 CLDN4 CALB2
7 basan syndrome 10.3 SMARCA4 SMARCA2
8 gallbladder small cell carcinoma 10.3 ENO2 CHL1
9 mediastinum sarcoma 10.3 SMARCA4 CALB2
10 lung sarcoma 10.3 MYOG CALB2
11 lymphohistiocytoid mesothelioma 10.3 CLDN4 CALB2
12 pulmonary neuroendocrine tumor 10.3 ENO2 CHL1
13 malignant glandular tumor of peripheral nerve sheath 10.3 MYOG CALB2
14 cervical carcinosarcoma 10.3 MYOG CALB2
15 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOG ENO2
16 ectomesenchymoma 10.3 MYOG ENO2
17 endobronchial leiomyoma 10.3 MYOG ENO2
18 scrotum neoplasm 10.3 MYOG CALB2
19 malignant triton tumor 10.2 MYOG ENO2
20 mediastinal cancer 10.2 ENO2 CALB2
21 askin's tumor 10.2 MYOG ENO2
22 neurohypophysis granular cell tumor 10.2 ENO2 CHL1 CALB2
23 monophasic synovial sarcoma 10.2 MYOG CALB2
24 posterior pituitary gland neoplasm 10.2 SMARCB1 SMARCA4
25 central nervous system melanocytic neoplasm 10.2 HRAS ENO2
26 optic nerve astrocytoma 10.2 SMARCB1 ENO2
27 sarcomatoid mesothelioma 10.2 CLDN4 CALB2
28 heart sarcoma 10.2 MYOG CALB2
29 plexiform schwannoma 10.2 SMARCB1 ENO2
30 extraosseous ewing sarcoma 10.2 MYOG ENO2
31 schizophrenia 12 10.2 SMARCA2 CALB2
32 trachea carcinoma in situ 10.2 KRAS HRAS
33 fallopian tube endometrioid adenocarcinoma 10.2 MYOG CALB2
34 lung cancer 10.2
35 common bile duct neoplasm 10.2 KRAS HRAS
36 clear cell cystadenofibroma 10.2 TP53 CALB2
37 bladder urachal carcinoma 10.2 KRAS HRAS
38 hepatic flexure cancer 10.2 KRAS HRAS
39 urachus cancer 10.2 KRAS HRAS
40 adenosquamous lung carcinoma 10.2 KRAS HRAS
41 descending colon cancer 10.2 KRAS HRAS
42 sigmoid neoplasm 10.2 KRAS HRAS
43 appendiceal neoplasm 10.2 KRAS HRAS
44 biphasic synovial sarcoma 10.2 SMARCB1 CALB2
45 acneiform dermatitis 10.2 KRAS HRAS
46 transverse colon cancer 10.2 KRAS HRAS
47 fallopian tube carcinosarcoma 10.2 TP53 CALB2
48 noonan syndrome-like disorder with loose anagen hair 1 10.2 KRAS HRAS
49 ascending colon cancer 10.2 KRAS HRAS
50 frontal lobe neoplasm 10.2 TP53 ENO2

Graphical network of the top 20 diseases related to Large Cell Carcinoma with Rhabdoid Phenotype:



Diseases related to Large Cell Carcinoma with Rhabdoid Phenotype

Symptoms & Phenotypes for Large Cell Carcinoma with Rhabdoid Phenotype

GenomeRNAi Phenotypes related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.23 BANF1 SMARCA4 SMARCB1 VEGFA
2 Increased Nanog expression GR00371-A-2 9.23 VEGFA
3 Increased Nanog expression GR00371-A-4 9.23 VEGFA
4 Increased Nanog expression GR00371-A-5 9.23 BANF1 VEGFA
5 Increased proliferation GR00094-A 8.96 SMARCB1 TP53

MGI Mouse Phenotypes related to Large Cell Carcinoma with Rhabdoid Phenotype:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.15 CHL1 CLDN4 ENO2 HRAS KEAP1 KRAS
2 normal MP:0002873 10.06 CALB2 CLDN4 HRAS KRAS MYOG SMARCA4
3 neoplasm MP:0002006 10.02 HRAS KRAS SMARCA2 SMARCA4 SMARCB1 TP53
4 muscle MP:0005369 10.01 HRAS KRAS MYOG SMARCA2 SMARCA4 SMARCB1
5 renal/urinary system MP:0005367 9.98 CLDN4 HRAS KRAS SMARCA2 SMARCA4 TP53
6 digestive/alimentary MP:0005381 9.97 HRAS KEAP1 KRAS MUC5AC SMARCA2 SMARCA4
7 behavior/neurological MP:0005386 9.93 CALB2 CHL1 CLDN4 ENO2 HRAS KRAS
8 craniofacial MP:0005382 9.8 CHL1 ENO2 HRAS KRAS SMARCA4 TP53
9 respiratory system MP:0005388 9.61 CHL1 ENO2 HRAS KEAP1 KRAS MYOG
10 integument MP:0010771 9.28 HRAS KEAP1 KRAS MYOG SMARCA2 SMARCA4

Drugs & Therapeutics for Large Cell Carcinoma with Rhabdoid Phenotype

Search Clinical Trials, NIH Clinical Center for Large Cell Carcinoma with Rhabdoid Phenotype

Genetic Tests for Large Cell Carcinoma with Rhabdoid Phenotype

Anatomical Context for Large Cell Carcinoma with Rhabdoid Phenotype

Organs/tissues related to Large Cell Carcinoma with Rhabdoid Phenotype:

MalaCards : Lung, Skeletal Muscle

Publications for Large Cell Carcinoma with Rhabdoid Phenotype

Articles related to Large Cell Carcinoma with Rhabdoid Phenotype:

# Title Authors PMID Year
1
[A clinical review of 3 cases of children with bronchial tumor]. 62
26696483 2015
2
Large cell lung carcinoma with rhabdoid phenotype: Report of a rare entity presenting with chest wall involvement. 62
26458655 2015
3
Large cell carcinoma of lung: On the verge of extinction? 62
25023633 2014
4
Pulmonary large cell carcinoma with rhabdoid phenotype. 62
16084457 2005
5
Pulmonary large cell carcinoma with rhabdoid phenotype. 62
12554537 2003

Variations for Large Cell Carcinoma with Rhabdoid Phenotype

Expression for Large Cell Carcinoma with Rhabdoid Phenotype

Search GEO for disease gene expression data for Large Cell Carcinoma with Rhabdoid Phenotype.

Pathways for Large Cell Carcinoma with Rhabdoid Phenotype

Pathways related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 VEGFA TP53 SMARCB1 SMARCA4 SMARCA2 KRAS
2
Show member pathways
12.53 VEGFA TP53 KRAS HRAS
3 12 CLDN4 HRAS KRAS TP53
4 11.94 VEGFA TP53 SMARCA4 KRAS
5 11.8 VEGFA KRAS HRAS
6 11.74 TP53 KRAS HRAS
7
Show member pathways
11.61 TP53 KRAS HRAS
8
Show member pathways
11.54 TP53 SMARCB1 SMARCA4 SMARCA2
9 11.49 TP53 SMARCA2 HRAS
10
Show member pathways
11.41 SMARCB1 SMARCA4 SMARCA2 KRAS HRAS
11
Show member pathways
11.4 VEGFA SMARCB1 SMARCA4 SMARCA2
12 11.32 VEGFA KRAS HRAS
13 11.23 SMARCB1 SMARCA4 SMARCA2
14 11.17 KRAS HRAS BANF1
15 11.16 TP53 KRAS HRAS
16 11.06 VEGFA KRAS HRAS
17 11.06 VEGFA TP53 KRAS HRAS
18 10.91 VEGFA MYOG
19 10.88 VEGFA TP53 KRAS KEAP1 HRAS
20 10.87 VEGFA KRAS HRAS
21 10.77 SMARCB1 SMARCA4
22 10.76 VEGFA KEAP1
23
Show member pathways
10.63 KRAS HRAS

GO Terms for Large Cell Carcinoma with Rhabdoid Phenotype

Cellular components related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.88 SMARCB1 SMARCA4 SMARCA2
2 nBAF complex GO:0071565 9.8 SMARCB1 SMARCA4 SMARCA2
3 npBAF complex GO:0071564 9.73 SMARCB1 SMARCA4 SMARCA2
4 germ cell nucleus GO:0043073 9.67 TP53 SMARCB1
5 bBAF complex GO:0140092 9.63 SMARCB1 SMARCA4 SMARCA2
6 DNA packaging complex GO:0044815 9.13 SMARCB1 SMARCA4 SMARCA2
7 SWI/SNF superfamily-type complex GO:0070603 8.8 SMARCB1 SMARCA4 SMARCA2

Biological processes related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.21 TP53 SMARCB1 SMARCA2 MYOG HRAS
2 positive regulation of cell differentiation GO:0045597 9.97 SMARCB1 SMARCA4 SMARCA2
3 regulation of G1/S transition of mitotic cell cycle GO:2000045 9.95 SMARCB1 SMARCA4 SMARCA2
4 positive regulation of stem cell population maintenance GO:1902459 9.93 SMARCB1 SMARCA4 SMARCA2
5 positive regulation of double-strand break repair GO:2000781 9.88 SMARCA2 SMARCA4 SMARCB1
6 positive regulation of T cell differentiation GO:0045582 9.85 SMARCB1 SMARCA4 SMARCA2
7 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.83 SMARCB1 SMARCA4
8 regulation of mitotic metaphase/anaphase transition GO:0030071 9.8 SMARCB1 SMARCA4 SMARCA2
9 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.73 VEGFA TP53
10 regulation of nucleotide-excision repair GO:2000819 9.63 SMARCB1 SMARCA4 SMARCA2
11 positive regulation of glucose mediated signaling pathway GO:1902661 9.56 SMARCB1 SMARCA4
12 regulation of G0 to G1 transition GO:0070316 9.43 SMARCB1 SMARCA4 SMARCA2
13 positive regulation of myoblast differentiation GO:0045663 9.23 SMARCB1 SMARCA4 SMARCA2 MYOG

Molecular functions related to Large Cell Carcinoma with Rhabdoid Phenotype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Tat protein binding GO:0030957 9.46 SMARCB1 SMARCA4
2 p53 binding GO:0002039 9.43 TP53 SMARCB1 SMARCA4
3 RNA polymerase I core promoter sequence-specific DNA binding GO:0001164 8.92 SMARCB1 SMARCA4

Sources for Large Cell Carcinoma with Rhabdoid Phenotype

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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