Large Cell Medulloblastoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Cell Medulloblastoma

MalaCards integrated aliases for Large Cell Medulloblastoma:

Name: Large Cell Medulloblastoma ¹² ¹⁵ ¹⁷ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3857

NCIt ⁵⁰ C6904

SNOMED-CT ⁶⁷ 128790006

EFO ¹⁷ EFO_0008508

UMLS ⁷⁰ C1266180

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Summaries for Large Cell Medulloblastoma

Disease Ontology : ¹² A medulloblastoma that is characterized by cells that are larger than would be normally expected.

MalaCards based summary : Large Cell Medulloblastoma is related to anaplastic/large cell medulloblastoma and melanotic neuroectodermal tumor, and has symptoms including vomiting, headache and gait ataxia. An important gene associated with Large Cell Medulloblastoma is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are ERK Signaling and Gastric cancer. Affiliated tissues include thyroid, lung and breast, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Large Cell Medulloblastoma

Diseases related to Large Cell Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)

#	Related Disease	Score	Top Affiliating Genes
1	anaplastic/large cell medulloblastoma	32.6	BRCA2 ALK
2	melanotic neuroectodermal tumor	30.1	VIM SYP
3	hepatoblastoma	29.8	MYC MET HGF
4	medulloblastoma	27.9	VIM SYP SUFU SHH PAX6 MYC
5	b-lymphoblastic leukemia/lymphoma with hyperdiploidy	10.3	BRCA2 ALK
6	sarcomatoid transitional cell carcinoma	10.3	SYP ALK
7	vulva basal cell carcinoma	10.3	SYP MYC
8	frontal lobe neoplasm	10.3	SYP MYC
9	pediatric lymphoma	10.3	MYC ALK
10	pax6-related aniridia	10.3	PAX6 BRCA2
11	pulmonary large cell neuroendocrine carcinoma	10.3	SYP ALK
12	occipital lobe neoplasm	10.3	MET ALK
13	adult lymphoma	10.3	MYC ALK
14	alk-negative anaplastic large cell lymphoma	10.3	MYC ALK
15	chronic erosive gastritis	10.3	MET HGF
16	doxorubicin induced cardiomyopathy	10.2	MET HGF
17	autonomic nervous system benign neoplasm	10.2	SYP ALK
18	pediatric hepatocellular carcinoma	10.2	MET HGF
19	heart lymphoma	10.2	VIM ALK
20	peripheral nervous system benign neoplasm	10.2	SYP ALK
21	familial renal papillary carcinoma	10.2	MET HGF
22	primary hepatic neuroendocrine carcinoma	10.2	VIM SYP
23	glomangiomyoma	10.2	VIM SYP
24	papillary tumor of the pineal region	10.2	VIM SYP
25	deafness, autosomal recessive 97	10.2	MET HGF
26	papillary thyroid microcarcinoma	10.2	MET HGF
27	esophageal adenoid cystic carcinoma	10.2	VIM SYP
28	angiocentric glioma	10.2	VIM SYP
29	glomangioma	10.2	VIM SYP
30	chordoid meningioma	10.2	VIM SYP
31	anaplastic ependymoma	10.2	VIM SYP
32	rhabdoid meningioma	10.2	VIM SYP
33	b-lymphoblastic leukemia/lymphoma	10.2	MYC BRCA2 ALK
34	small cell carcinoma	10.2	SYP BRCA2 ALK
35	muscle cancer	10.2	SYP MYC ALK
36	clear cell ependymoma	10.2	VIM SYP
37	papillary adenoma	10.2	VIM SYP
38	hereditary renal cell carcinoma	10.2	MET HGF
39	granulosa cell tumor of the ovary	10.2	VIM SYP
40	central epithelioid sarcoma	10.2	VIM SYP
41	breast carcinoma in situ	10.2	MYC MET BRCA2
42	vulvar proximal-type epithelioid sarcoma	10.2	VIM SYP
43	cerebellum cancer	10.1	SYP SHH
44	clear cell meningioma	10.1	VIM SYP
45	cerebellar medulloblastoma	10.1	SYP SHH
46	autonomic nervous system neoplasm	10.1	SYP MYC ALK
47	thyroid gland follicular carcinoma	10.1	MYC MET ALK
48	central nervous system primitive neuroectodermal neoplasm	10.1	SYP SHH
49	peripheral nervous system neoplasm	10.1	SYP MYC ALK
50	cellular ependymoma	10.1	VIM SYP

Graphical network of the top 20 diseases related to Large Cell Medulloblastoma:

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Symptoms & Phenotypes for Large Cell Medulloblastoma

UMLS symptoms related to Large Cell Medulloblastoma:

vomiting; headache; gait ataxia

GenomeRNAi Phenotypes related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	9.77	ALK HGF MYC NME2
2	Decreased viability	GR00221-A-2	9.77	HGF NME2
3	Decreased viability	GR00221-A-3	9.77	MYC
4	Decreased viability	GR00221-A-4	9.77	ALK HGF
5	Decreased viability	GR00249-S	9.77	ALK MYC
6	Decreased viability	GR00402-S-2	9.77	MYC NME2
7	Misorientated spindle	GR00256-A	8.62	ALK NME2

MGI Mouse Phenotypes related to Large Cell Medulloblastoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.13	ALK BRCA2 HGF MET MYC PAX6
2	embryo	MP:0005380	9.97	BRCA2 HGF MET MYC PAX6 SHH
3	nervous system	MP:0003631	9.96	ALK BRCA2 HGF MET MYC PAX6
4	digestive/alimentary	MP:0005381	9.95	BRCA2 MET MYC NME2 PAX6 SHH
5	neoplasm	MP:0002006	9.87	ALK BRCA2 MET MYC PAX6 SHH
6	normal	MP:0002873	9.81	ALK BRCA2 MET MYC PAX6 SHH
7	pigmentation	MP:0001186	9.35	ALK HGF MYC PAX6 SUFU
8	respiratory system	MP:0005388	9.1	ALK MET PAX6 SHH SUFU VIM

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Drugs & Therapeutics for Large Cell Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Large Cell Medulloblastoma

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Genetic Tests for Large Cell Medulloblastoma

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Anatomical Context for Large Cell Medulloblastoma

MalaCards organs/tissues related to Large Cell Medulloblastoma:

⁴⁰

Thyroid, Lung, Breast, Skin, Brain, Cerebellum, Heart

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Publications for Large Cell Medulloblastoma

Articles related to Large Cell Medulloblastoma:

(show all 26)

#	Title	Authors	PMID	Year
1	Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update. ⁶¹	Todeschi J...Klein O	33340509	2021
2	Surgical management of posterior fossa medulloblastoma in children: The Lyon experience. ⁶¹	Grassiot B...Mottolese C	33482236	2021
3	5ALA in pediatric brain tumors is not routinely beneficial. ⁶¹	Roth J...Constantini S	28293736	2017
4	Demographics, patterns of care, and survival in pediatric medulloblastoma. ⁶¹	Dressler EV...Villano JL	28290003	2017
5	The gut or the brain?--Gastrointestinal misdiagnoses of infantile brain tumors. ⁶¹	Teo WY...Myseros JS	24535228	2014
6	Histological variants of medulloblastoma are the most powerful clinical prognostic indicators. ⁶¹	Massimino M...Giangaspero F	22693015	2013
7	Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead state. ⁶¹	Miwa T...Ida H	21533576	2011
8	Magnetic resonance imaging spectrum of medulloblastoma. ⁶¹	Fruehwald-Pallamar J...Thurnher MM	21279509	2011
9	Diffuse postoperative cerebellar swelling in medulloblastoma: report of two cases. ⁶¹	Ogiwara H...Alden TD	21103880	2011
10	PARP1 expression in pediatric central nervous system tumors. ⁶¹	Barton VN...Foreman NK	19533660	2009
11	Occult leptomeningeal large cell medulloblastoma in an adult. ⁶¹	Rushing EJ...Azumi N	19537136	2009
12	Histologic features and prognosis in pediatric medulloblastoma. ⁶¹	Verma S...Gilles FH	18201118	2008
13	Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis. ⁶¹	Polydorides AD...Edgar MA	18317693	2008
14	Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. ⁶¹	Li Y...Abounader R	18059365	2008
15	Morphophenotype of medulloblastoma in children and adults. The size of nuclei. ⁶¹	Dagostino C...Giordana MT	17007445	2006
16	Three-dimensional (3D) reconstruction and quantitative analysis of the microvasculature in medulloblastoma and ependymoma subtypes. ⁶¹	Gilhuis HJ...Wesseling P	17109194	2006
17	Anaplasia is rare and does not influence prognosis in adult medulloblastoma. ⁶¹	Giordana MT...Chio A	16215458	2005
18	Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence. ⁶¹	Donner LR	15759130	2005
19	Large-cell medulloblastoma in Aicardi syndrome. Case report and literature review. ⁶¹	Palmer L...Kyllerman M	15534766	2004
20	Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. ⁶¹	Behrends U...Mautner J	12800201	2003
21	Large-cell medulloblastoma with arrestin-like protein expression. ⁶¹	Vincent S...Ruchoux MM	12617187	2003
22	[The new WHO classification of tumors of the nervous system 2000. Pathology and genetics]. ⁶¹	Radner H...Wiestler OD	12185780	2002
23	The WHO classification of tumors of the nervous system. ⁶¹	Kleihues P...Cavenee WK	11895036	2002
24	Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma. ⁶¹	Reardon DA...Kun LK	10940769	2000
25	2000 World Health Organization classification of tumors of the nervous system. ⁶¹	Biernat W	11247393	2000
26	Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. ⁶¹	Giangaspero F...Montaldi A	1530108	1992

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Genes for Large Cell Medulloblastoma

Genes related to Large Cell Medulloblastoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	12.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SYP	Synaptophysin	Protein Coding	11.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	10.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	PAX6	Paired Box 6	Protein Coding	10.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	HGF	Hepatocyte Growth Factor	Protein Coding	9.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	7.44	GeneCards inferred via : Variants (show sections)
7	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	7.09	GeneCards inferred via : Variants (show sections)
8	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	6.43	GeneCards inferred via : Publications (show sections)
9	VIM	Vimentin	Protein Coding	6.43	GeneCards inferred via : Publications (show sections)
10	JKAMP	JNK1/MAPK8 Associated Membrane Protein	Protein Coding	6.39	DISEASES inferred ¹⁵
11	FAM184A	Family With Sequence Similarity 184 Member A	Protein Coding	6.26	DISEASES inferred ¹⁵
12	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	6.08	DISEASES inferred ¹⁵
13	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	5.84	DISEASES inferred ¹⁵

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Variations for Large Cell Medulloblastoma

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Expression for Large Cell Medulloblastoma

Search GEO for disease gene expression data for Large Cell Medulloblastoma.

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Pathways for Large Cell Medulloblastoma

Pathways related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.54	VIM SUFU PAX6 MYC MET HGF
2	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.39	SHH MYC MET HGF BRCA2
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.38	MET HGF BRCA2 ALK
4	Pathways in cancer ³⁶	12.22	SUFU SHH MYC MET HGF BRCA2
5	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.13	PAX6 MET HGF ALK
6	Proteoglycans in cancer ³⁶	11.98	SHH MYC MET HGF
7	Ectoderm Differentiation ¹	11.84	SHH PAX6 MYC
8	Interleukin-4 and 13 signaling ⁶⁵	11.67	VIM MYC HGF
9	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.35	VIM SYP SHH PAX6
10	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.22	VIM SHH PAX6 MYC MET HGF
11	Differentiation Pathway ¹	11.11	SHH HGF ALK
12	Extracellular vesicle-mediated signaling in recipient cells ¹	11.02	MET HGF
13	Hedgehog Signaling Pathway (WikiPathways) ¹ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁵	10.77	SUFU SHH
14	Syndecan-1-mediated signaling events ¹	10.69	MET HGF
15	MET activates PI3K/AKT signaling ⁶⁵ Show member pathways MET activates PTPN11 ⁶⁵	10.45	MET HGF

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GO Terms for Large Cell Medulloblastoma

Biological processes related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.87	VIM SHH PAX6 MYC
2	positive regulation of transcription by RNA polymerase II	GO:0045944	9.85	SHH PAX6 NME2 MYC MET HGF
3	positive regulation of transcription, DNA-templated	GO:0045893	9.83	SHH PAX6 NME2 MYC BRCA2
4	chromosome organization	GO:0051276	9.58	MYC BRCA2
5	neuron fate commitment	GO:0048663	9.56	SHH PAX6
6	pancreas development	GO:0031016	9.55	SHH MET
7	branching morphogenesis of an epithelial tube	GO:0048754	9.54	SHH MET
8	response to gamma radiation	GO:0010332	9.52	MYC BRCA2
9	positive regulation of neuroblast proliferation	GO:0002052	9.51	SHH PAX6
10	positive regulation of mesenchymal cell proliferation	GO:0002053	9.49	SHH MYC
11	intermediate filament organization	GO:0045109	9.48	VIM SHH
12	positive regulation of DNA biosynthetic process	GO:2000573	9.46	MYC HGF
13	hepatocyte growth factor receptor signaling pathway	GO:0048012	9.4	MET HGF
14	smoothened signaling pathway	GO:0007224	9.33	SUFU SHH PAX6
15	Bergmann glial cell differentiation	GO:0060020	9.32	VIM SHH
16	telencephalon regionalization	GO:0021978	9.26	SHH PAX6
17	spinal cord dorsal/ventral patterning	GO:0021513	8.96	SUFU SHH
18	negative regulation of hydrogen peroxide-mediated programmed cell death	GO:1901299	8.62	MET HGF

Molecular functions related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.17	VIM SYP NME2 MET HGF BRCA2

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Sources for Large Cell Medulloblastoma

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⁵⁷ OMIM® (Updated 20-May-2021)

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