Large Cell Medulloblastoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Cell Medulloblastoma

MalaCards integrated aliases for Large Cell Medulloblastoma:

Name: Large Cell Medulloblastoma ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3857

NCIt ⁵⁰ C6904

SNOMED-CT ⁶⁸ 128790006

UMLS ⁷³ C1266180

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Summaries for Large Cell Medulloblastoma

Disease Ontology : ¹² A medulloblastoma that is characterized by cells that are larger than would be normally expected.

MalaCards based summary : Large Cell Medulloblastoma is related to medulloblastoma and anaplastic/large cell medulloblastoma, and has symptoms including headache, vomiting and gait ataxia. An important gene associated with Large Cell Medulloblastoma is SYP (Synaptophysin), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Etoposide and Antineoplastic Agents, Phytogenic have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is behavior/neurological.

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Related Diseases for Large Cell Medulloblastoma

Diseases related to Large Cell Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	medulloblastoma	28.7	HGF MYC PAX6 SYP
2	anaplastic/large cell medulloblastoma	12.1
3	venous hemangioma	10.3	MYC SYP
4	cerebral primitive neuroectodermal tumor	10.3	MYC SYP
5	medullomyoblastoma	10.3	MYC SYP
6	infratentorial cancer	10.2	MYC SYP
7	peripheral nervous system neoplasm	10.2	MYC SYP
8	autonomic nervous system neoplasm	10.2	MYC SYP
9	nervous system cancer	10.1	MYC SYP
10	childhood medulloblastoma	10.1	MYC PRDM13
11	cell type cancer	9.9	MYC SYP
12	alveolar soft part sarcoma	9.7	MET SYP
13	aicardi syndrome	9.7
14	deafness, autosomal recessive 39	9.7	HGF MET
15	deafness, autosomal recessive 97	9.6	HGF MET
16	endometrial squamous cell carcinoma	9.6	HGF MET
17	doxorubicin induced cardiomyopathy	9.6	HGF MET
18	papillary thyroid microcarcinoma	9.6	HGF MET
19	familial renal papillary carcinoma	9.6	HGF MET
20	respiratory system cancer	9.6	MET MYC
21	spindle cell synovial sarcoma	9.6	HGF MET
22	spinal chordoma	9.5	HGF MET
23	ewing sarcoma	9.4	MYC PAX6 SYP
24	autosomal recessive non-syndromic sensorineural deafness type dfnb	9.4	HGF MET
25	gastrointestinal system cancer	9.3	MET MYC
26	gastric cancer	8.3	HGF MET MYC

Graphical network of the top 20 diseases related to Large Cell Medulloblastoma:

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Symptoms & Phenotypes for Large Cell Medulloblastoma

UMLS symptoms related to Large Cell Medulloblastoma:

headache, vomiting, gait ataxia

MGI Mouse Phenotypes related to Large Cell Medulloblastoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.02	MET MYC PAX6 PRDM13 SYP

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Drugs & Therapeutics for Large Cell Medulloblastoma

Drugs for Large Cell Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Etoposide

Approved

Phase 2

33419-42-0

36462

Synonyms:

(−)-etoposide

(-)-Etoposide

121471-01-0

136598-18-0

201594-04-9

33419-42-0

35317-32-9

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside

4-demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside

4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin

51854-34-3

76576-58-4

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

AB00438905

AC1L1FN8

AC1L1VT3

AC1L6246

AC1NR4OG

AC1O4WGG

AC1O7M1N

AC1Q47JJ

alpha-D-Glucopyranosyl isomer etoposide

Ambap33419-42-0

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bio1_000489

Bio1_000978

Bio1_001467

BPBio1_000673

BRD-K37798499-001-02-5

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

BSPBio_000611

C01576

CCRIS 2392

Celltop

CHEBI:4911

CHEBI:588795

CHEMBL44657

CID11758093

CID284997

CID3310

CID36462

CID5284558

CID6419930

CID6610299

CPD000112002

D00125

DB00773

DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,

Demethyl epipodophyllotoxin ethylidine glucoside

Demethyl Epipodophyllotoxin Ethylidine Glucoside

Demethyl-epiodophyllotoxin ethylidene glucoside

Demethylepipodophyllotoxin-beta-D-ethylideneglucoside

E0675

E1383_SIGMA

EINECS 251-509-1

Epipodophyllotoxin VP-16213

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

Eposide

Eposin

Eposin, Vepesid, VP-16, Toposar, Etoposide

eto GRY

eto-GRY

Etomedac

ETOP

Etopol

Etopophos

Etopophos (phosphate salt)

Etopos

etoposide

Etoposide (JP15/USP/INN)

Etoposide (VP16)

Etoposide [USAN:INN:BAN:JAN]

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido [INN-Spanish]

etoposido Ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Etosid

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

HMS1569O13

HMS2052N05

HMS2089F14

HSDB 6517

I06-0248

KBioSS_002410

Lastet

Lemery brand OF etoposide

LS-1214

Medac brand OF etoposide

MLS000049957

MLS001074951

MLS001424283

MLS002153463

MLS002207239

MLS002222184

MolPort-003-983-431

MolPort-004-905-001

MolPort-004-955-161

NCGC00025056-02

NChemBio.2007.10-comp19

nchembio.573-comp8

nchembio873-comp2

NK 171

Novartis brand OF etoposide

NSC 141540

NSC141540

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Prestwick_211

Prestwick0_000396

Prestwick1_000396

Prestwick2_000396

Prestwick3_000396

Riboposid

Ribosepharm brand OF etoposide

S1225_Selleck

SAM001246880

Sanfer brand OF etoposide

SMR000112002

SPBio_002532

ST056353

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Toposar

trans-Etoposide

UNII-6PLQ3CP4P3

Vepesid

VePesid

VePESID (TN)

Vepesid J

Vepeside

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16 (pharmaceutical)

VP 16213

VP 16-213

VP-16

VP-16-213

ZINC03830818

ZINC03938684

Zuyeyidal

2

Antineoplastic Agents, Phytogenic

Phase 2

3

Etoposide phosphate

Phase 2

4

Topoisomerase Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult Medulloblastomas	Recruiting	NCT01857453	Phase 2	carboplatine;Etoposide

Search NIH Clinical Center for Large Cell Medulloblastoma

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Genetic Tests for Large Cell Medulloblastoma

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Anatomical Context for Large Cell Medulloblastoma

MalaCards organs/tissues related to Large Cell Medulloblastoma:

⁴¹

Brain

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Publications for Large Cell Medulloblastoma

Articles related to Large Cell Medulloblastoma:

#	Title	Authors	Year
1	Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead state. ( 21533576 )	Miwa T....Ida H.	2011
2	Occult leptomeningeal large cell medulloblastoma in an adult. ( 19537136 )	Rushing E.J....Azumi N.	2009
3	Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis. ( 18317693 )	Polydorides A.D....Edgar M.A.	2008
4	Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. ( 18059365 )	Li Y....Abounader R.	2008
5	Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence. ( 15759130 )	Donner L.R.	2005
6	Large-cell medulloblastoma in Aicardi syndrome. Case report and literature review. ( 15534766 )	PalmAcr L....Kyllerman M.	2004
7	Large-cell medulloblastoma with arrestin-like protein expression. ( 12617187 )	Vincent S....Ruchoux M.M.	2003
8	Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma. ( 10940769 )	Reardon D.A....Kun L.K.	2000

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Genes for Large Cell Medulloblastoma

Genes related to Large Cell Medulloblastoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYP	Synaptophysin	Protein Coding	21.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	21.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	PAX6	Paired Box 6	Protein Coding	20.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HGF	Hepatocyte Growth Factor	Protein Coding	20.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	20.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	PRDM13	PR/SET Domain 13	Protein Coding	17.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Large Cell Medulloblastoma

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Expression for Large Cell Medulloblastoma

Search GEO for disease gene expression data for Large Cell Medulloblastoma.

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Pathways for Large Cell Medulloblastoma

Pathways related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.47	HGF MET MYC
2	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.39	HGF MET MYC
3	MAPK signaling pathway ¹ ³⁷	12.38	HGF MET MYC
4	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	11.94	HGF MET MYC
5	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	11.74	MET MYC
6	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.68	HGF MET MYC
7	Proteoglycans in cancer ³⁷	11.64	HGF MET MYC
8	Listeria monocytogenes entry into host cells ⁶⁶ Show member pathways E-cadherin signaling events ¹ EGFR downregulation ⁶⁶ InlA-mediated entry of Listeria monocytogenes into host cells ⁶⁶ InlB-mediated entry of Listeria monocytogenes into host cell ⁶⁶ Negative regulation of MET activity ⁶⁶	11.55	HGF MET
9	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.46	PAX6 SYP
10	Central carbon metabolism in cancer ³⁷	11.34	MET MYC
11	P38 MAPK Signaling Pathway (sino) ⁶⁷	11.3	MYC PAX6
12	Malaria ³⁷	11.17	HGF MET
13	FGF signaling pathway ¹	11.13	HGF MET
14	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁶	11.06	HGF MET
15	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.05	HGF MET MYC PAX6
16	Stabilization and expansion of the E-cadherin adherens junction ¹	11.01	HGF MET
17	Arf6 signaling events ¹	10.9	HGF MET
18	Extracellular vesicle-mediated signaling in recipient cells ¹	10.73	HGF MET
19	Syndecan-1-mediated signaling events ¹	10.19	HGF MET

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GO Terms for Large Cell Medulloblastoma

Biological processes related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.71	HGF MET MYC PAX6
2	negative regulation of apoptotic process	GO:0043066	9.67	HGF MET MYC
3	cell proliferation	GO:0008283	9.61	HGF MET MYC
4	phosphatidylinositol phosphorylation	GO:0046854	9.51	HGF MET
5	liver development	GO:0001889	9.48	HGF MET
6	response to wounding	GO:0009611	9.46	MYC PAX6
7	MAPK cascade	GO:0000165	9.43	HGF MET MYC
8	negative regulation of autophagy	GO:0010507	9.37	HGF MET
9	positive chemotaxis	GO:0050918	9.32	HGF MET
10	positive regulation of DNA biosynthetic process	GO:2000573	9.16	HGF MYC
11	hepatocyte growth factor receptor signaling pathway	GO:0048012	8.96	HGF MET
12	negative regulation of hydrogen peroxide-mediated programmed cell death	GO:1901299	8.62	HGF MET

Molecular functions related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	8.62	HGF MET

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Sources for Large Cell Medulloblastoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia