MCID: LRG003
MIFTS: 34

Large Cell Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Large Cell Medulloblastoma

MalaCards integrated aliases for Large Cell Medulloblastoma:

Name: Large Cell Medulloblastoma 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3857
NCIt 50 C6904
SNOMED-CT 67 128790006
UMLS 70 C1266180

Summaries for Large Cell Medulloblastoma

Disease Ontology : 12 A medulloblastoma that is characterized by cells that are larger than would be normally expected.

MalaCards based summary : Large Cell Medulloblastoma is related to anaplastic/large cell medulloblastoma and melanotic neuroectodermal tumor, and has symptoms including vomiting, headache and gait ataxia. An important gene associated with Large Cell Medulloblastoma is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are ERK Signaling and Gastric cancer. Affiliated tissues include thyroid, lung and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Large Cell Medulloblastoma

Diseases related to Large Cell Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 anaplastic/large cell medulloblastoma 32.6 BRCA2 ALK
2 melanotic neuroectodermal tumor 30.1 VIM SYP
3 hepatoblastoma 29.8 MYC MET HGF
4 medulloblastoma 27.9 VIM SYP SUFU SHH PAX6 MYC
5 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.3 BRCA2 ALK
6 sarcomatoid transitional cell carcinoma 10.3 SYP ALK
7 vulva basal cell carcinoma 10.3 SYP MYC
8 frontal lobe neoplasm 10.3 SYP MYC
9 pediatric lymphoma 10.3 MYC ALK
10 pax6-related aniridia 10.3 PAX6 BRCA2
11 pulmonary large cell neuroendocrine carcinoma 10.3 SYP ALK
12 occipital lobe neoplasm 10.3 MET ALK
13 adult lymphoma 10.3 MYC ALK
14 alk-negative anaplastic large cell lymphoma 10.3 MYC ALK
15 chronic erosive gastritis 10.3 MET HGF
16 doxorubicin induced cardiomyopathy 10.2 MET HGF
17 autonomic nervous system benign neoplasm 10.2 SYP ALK
18 pediatric hepatocellular carcinoma 10.2 MET HGF
19 heart lymphoma 10.2 VIM ALK
20 peripheral nervous system benign neoplasm 10.2 SYP ALK
21 familial renal papillary carcinoma 10.2 MET HGF
22 primary hepatic neuroendocrine carcinoma 10.2 VIM SYP
23 glomangiomyoma 10.2 VIM SYP
24 papillary tumor of the pineal region 10.2 VIM SYP
25 deafness, autosomal recessive 97 10.2 MET HGF
26 papillary thyroid microcarcinoma 10.2 MET HGF
27 esophageal adenoid cystic carcinoma 10.2 VIM SYP
28 angiocentric glioma 10.2 VIM SYP
29 glomangioma 10.2 VIM SYP
30 chordoid meningioma 10.2 VIM SYP
31 anaplastic ependymoma 10.2 VIM SYP
32 rhabdoid meningioma 10.2 VIM SYP
33 b-lymphoblastic leukemia/lymphoma 10.2 MYC BRCA2 ALK
34 small cell carcinoma 10.2 SYP BRCA2 ALK
35 muscle cancer 10.2 SYP MYC ALK
36 clear cell ependymoma 10.2 VIM SYP
37 papillary adenoma 10.2 VIM SYP
38 hereditary renal cell carcinoma 10.2 MET HGF
39 granulosa cell tumor of the ovary 10.2 VIM SYP
40 central epithelioid sarcoma 10.2 VIM SYP
41 breast carcinoma in situ 10.2 MYC MET BRCA2
42 vulvar proximal-type epithelioid sarcoma 10.2 VIM SYP
43 cerebellum cancer 10.1 SYP SHH
44 clear cell meningioma 10.1 VIM SYP
45 cerebellar medulloblastoma 10.1 SYP SHH
46 autonomic nervous system neoplasm 10.1 SYP MYC ALK
47 thyroid gland follicular carcinoma 10.1 MYC MET ALK
48 central nervous system primitive neuroectodermal neoplasm 10.1 SYP SHH
49 peripheral nervous system neoplasm 10.1 SYP MYC ALK
50 cellular ependymoma 10.1 VIM SYP

Graphical network of the top 20 diseases related to Large Cell Medulloblastoma:



Diseases related to Large Cell Medulloblastoma

Symptoms & Phenotypes for Large Cell Medulloblastoma

UMLS symptoms related to Large Cell Medulloblastoma:


vomiting; headache; gait ataxia

GenomeRNAi Phenotypes related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.77 ALK HGF MYC NME2
2 Decreased viability GR00221-A-2 9.77 HGF NME2
3 Decreased viability GR00221-A-3 9.77 MYC
4 Decreased viability GR00221-A-4 9.77 ALK HGF
5 Decreased viability GR00249-S 9.77 ALK MYC
6 Decreased viability GR00402-S-2 9.77 MYC NME2
7 Misorientated spindle GR00256-A 8.62 ALK NME2

MGI Mouse Phenotypes related to Large Cell Medulloblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 ALK BRCA2 HGF MET MYC PAX6
2 embryo MP:0005380 9.97 BRCA2 HGF MET MYC PAX6 SHH
3 nervous system MP:0003631 9.96 ALK BRCA2 HGF MET MYC PAX6
4 digestive/alimentary MP:0005381 9.95 BRCA2 MET MYC NME2 PAX6 SHH
5 neoplasm MP:0002006 9.87 ALK BRCA2 MET MYC PAX6 SHH
6 normal MP:0002873 9.81 ALK BRCA2 MET MYC PAX6 SHH
7 pigmentation MP:0001186 9.35 ALK HGF MYC PAX6 SUFU
8 respiratory system MP:0005388 9.1 ALK MET PAX6 SHH SUFU VIM

Drugs & Therapeutics for Large Cell Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Large Cell Medulloblastoma

Genetic Tests for Large Cell Medulloblastoma

Anatomical Context for Large Cell Medulloblastoma

MalaCards organs/tissues related to Large Cell Medulloblastoma:

40
Thyroid, Lung, Breast, Skin, Brain, Cerebellum, Heart

Publications for Large Cell Medulloblastoma

Articles related to Large Cell Medulloblastoma:

(show all 26)
# Title Authors PMID Year
1
Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update. 61
33340509 2021
2
Surgical management of posterior fossa medulloblastoma in children: The Lyon experience. 61
33482236 2021
3
5ALA in pediatric brain tumors is not routinely beneficial. 61
28293736 2017
4
Demographics, patterns of care, and survival in pediatric medulloblastoma. 61
28290003 2017
5
The gut or the brain?--Gastrointestinal misdiagnoses of infantile brain tumors. 61
24535228 2014
6
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators. 61
22693015 2013
7
Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead state. 61
21533576 2011
8
Magnetic resonance imaging spectrum of medulloblastoma. 61
21279509 2011
9
Diffuse postoperative cerebellar swelling in medulloblastoma: report of two cases. 61
21103880 2011
10
PARP1 expression in pediatric central nervous system tumors. 61
19533660 2009
11
Occult leptomeningeal large cell medulloblastoma in an adult. 61
19537136 2009
12
Histologic features and prognosis in pediatric medulloblastoma. 61
18201118 2008
13
Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis. 61
18317693 2008
14
Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. 61
18059365 2008
15
Morphophenotype of medulloblastoma in children and adults. The size of nuclei. 61
17007445 2006
16
Three-dimensional (3D) reconstruction and quantitative analysis of the microvasculature in medulloblastoma and ependymoma subtypes. 61
17109194 2006
17
Anaplasia is rare and does not influence prognosis in adult medulloblastoma. 61
16215458 2005
18
Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence. 61
15759130 2005
19
Large-cell medulloblastoma in Aicardi syndrome. Case report and literature review. 61
15534766 2004
20
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. 61
12800201 2003
21
Large-cell medulloblastoma with arrestin-like protein expression. 61
12617187 2003
22
[The new WHO classification of tumors of the nervous system 2000. Pathology and genetics]. 61
12185780 2002
23
The WHO classification of tumors of the nervous system. 61
11895036 2002
24
Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma. 61
10940769 2000
25
2000 World Health Organization classification of tumors of the nervous system. 61
11247393 2000
26
Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. 61
1530108 1992

Variations for Large Cell Medulloblastoma

Expression for Large Cell Medulloblastoma

Search GEO for disease gene expression data for Large Cell Medulloblastoma.

Pathways for Large Cell Medulloblastoma

Pathways related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 VIM SUFU PAX6 MYC MET HGF
2
Show member pathways
12.39 SHH MYC MET HGF BRCA2
3
Show member pathways
12.38 MET HGF BRCA2 ALK
4 12.22 SUFU SHH MYC MET HGF BRCA2
5
Show member pathways
12.13 PAX6 MET HGF ALK
6 11.98 SHH MYC MET HGF
7 11.84 SHH PAX6 MYC
8 11.67 VIM MYC HGF
9 11.35 VIM SYP SHH PAX6
10 11.22 VIM SHH PAX6 MYC MET HGF
11 11.11 SHH HGF ALK
12 11.02 MET HGF
13
Show member pathways
10.77 SUFU SHH
14 10.69 MET HGF
15
Show member pathways
10.45 MET HGF

GO Terms for Large Cell Medulloblastoma

Biological processes related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.87 VIM SHH PAX6 MYC
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 SHH PAX6 NME2 MYC MET HGF
3 positive regulation of transcription, DNA-templated GO:0045893 9.83 SHH PAX6 NME2 MYC BRCA2
4 chromosome organization GO:0051276 9.58 MYC BRCA2
5 neuron fate commitment GO:0048663 9.56 SHH PAX6
6 pancreas development GO:0031016 9.55 SHH MET
7 branching morphogenesis of an epithelial tube GO:0048754 9.54 SHH MET
8 response to gamma radiation GO:0010332 9.52 MYC BRCA2
9 positive regulation of neuroblast proliferation GO:0002052 9.51 SHH PAX6
10 positive regulation of mesenchymal cell proliferation GO:0002053 9.49 SHH MYC
11 intermediate filament organization GO:0045109 9.48 VIM SHH
12 positive regulation of DNA biosynthetic process GO:2000573 9.46 MYC HGF
13 hepatocyte growth factor receptor signaling pathway GO:0048012 9.4 MET HGF
14 smoothened signaling pathway GO:0007224 9.33 SUFU SHH PAX6
15 Bergmann glial cell differentiation GO:0060020 9.32 VIM SHH
16 telencephalon regionalization GO:0021978 9.26 SHH PAX6
17 spinal cord dorsal/ventral patterning GO:0021513 8.96 SUFU SHH
18 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 8.62 MET HGF

Molecular functions related to Large Cell Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 VIM SYP NME2 MET HGF BRCA2

Sources for Large Cell Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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