MCID: LRG014
MIFTS: 40

Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Large Cell Neuroendocrine Carcinoma:

Name: Large Cell Neuroendocrine Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050872
UMLS 73 C1265996

Summaries for Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Large Cell Neuroendocrine Carcinoma is related to pulmonary large cell neuroendocrine carcinoma and ovarian large-cell neuroendocrine carcinoma. An important gene associated with Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and ovary, and related phenotypes are nervous system and normal

Related Diseases for Large Cell Neuroendocrine Carcinoma

Diseases related to Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 pulmonary large cell neuroendocrine carcinoma 34.1 CHGA ENO2 SYP
2 ovarian large-cell neuroendocrine carcinoma 33.7 CHGA KRT20 NCAM1 SYP
3 adenocarcinoma in situ 30.1 KRT20 KRT7
4 mucinous adenocarcinoma 30.0 EGFR KRT20 KRT7 NKX2-1
5 tubular adenocarcinoma 29.9 CHGA KRT20 SYP
6 papillary carcinoma 29.8 KRT20 KRT7 NKX2-1
7 lung cancer susceptibility 3 29.8 EGFR KRT20 KRT7 NKX2-1
8 adenosquamous carcinoma 29.7 EGFR KIT KRT7 NKX2-1
9 teratoma 29.6 ENO2 KIT KRT7 NKX2-1 SYP
10 large cell carcinoma 29.4 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
11 small cell carcinoma 29.4 CHGA EGFR ENO2 KIT KRT20 KRT7
12 gastric squamous cell carcinoma 29.4 CHGA ENO2 KRT7 NCAM1 SYP
13 cystic teratoma 29.4 ENO2 KRT20 KRT7 NKX2-1 SYP
14 lung cancer 28.8 ASCL1 CHGA EGFR ENO2 KIT KRT20
15 small cell cancer of the lung 28.6 ASCL1 CHGA EGFR ENO2 KIT KRT20
16 neuroendocrine tumor 28.4 ASCL1 CHGA ENO2 KRT20 KRT7 NCAM1
17 cervical large cell neuroendocrine carcinoma 12.5
18 lung combined large cell neuroendocrine carcinoma 12.4
19 breast large cell neuroendocrine carcinoma 12.4
20 thymus large cell carcinoma 11.7
21 adenocarcinoma 10.6
22 neuroendocrine carcinoma of the cervix 10.3
23 gastrointestinal neuroendocrine tumor 10.3 CHGA SYP
24 anterior cranial fossa meningioma 10.3 CHGA SYP
25 pleomorphic xanthoastrocytoma 10.3 CHGA SYP
26 peritoneal serous adenocarcinoma 10.3 CHGA SYP
27 cellular ependymoma 10.3 CHGA SYP
28 tanycytic ependymoma 10.3 CHGA SYP
29 pancreatoblastoma 10.3 CHGA SYP
30 non-functioning pancreatic endocrine tumor 10.3 CHGA SYP
31 olfactory groove meningioma 10.3 CHGA SYP
32 chordoid meningioma 10.3 CHGA SYP
33 binswanger's disease 10.3 CHGA SYP
34 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
35 seminal vesicle tumor 10.3 KRT7 SYP
36 fibrolamellar carcinoma 10.3 KRT7 SYP
37 cervical adenosquamous carcinoma 10.3 EGFR KRT7
38 oncocytic breast carcinoma 10.3 EGFR KRT7
39 perivascular epithelioid cell tumor 10.3 KIT SYP
40 mixed type thymoma 10.3 KIT SYP
41 functional colonic disease 10.3 KIT SYP
42 ovarian germ cell cancer 10.3 KRT7 NKX2-1
43 papillary adenoma 10.2 KRT7 NKX2-1
44 squamous cell carcinoma 10.2
45 gastric cardia carcinoma 10.2 CHGA KIT
46 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
47 ureter small cell carcinoma 10.2 CHGA SYP
48 adenomatoid tumor 10.2 KRT7 NKX2-1
49 malignant leydig cell tumor 10.2 KIT KRT7
50 alveoli adenoma 10.2 KRT7 NKX2-1

Graphical network of the top 20 diseases related to Large Cell Neuroendocrine Carcinoma:



Diseases related to Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Large Cell Neuroendocrine Carcinoma

MGI Mouse Phenotypes related to Large Cell Neuroendocrine Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.56 ASCL1 CHGA EGFR ENO2 KIT NCAM1
2 normal MP:0002873 9.1 ASCL1 EGFR KIT NKX2-1 SYP VIL1

Drugs & Therapeutics for Large Cell Neuroendocrine Carcinoma

Drugs for Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Somatostatin Approved, Investigational Phase 1, Phase 2 51110-01-1, 38916-34-6 53481605
5
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
6
Nivolumab Approved Phase 2 946414-94-4
7
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
8 Topoisomerase Inhibitors Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Etoposide phosphate Phase 2
11 Albumin-Bound Paclitaxel Phase 2
12 Antimitotic Agents Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Hormone Antagonists Phase 1, Phase 2
16 Immunologic Factors Phase 2
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Alkylating Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2
21 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Recruiting NCT02755675 Phase 2
3 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
4 Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Recruiting NCT02709889 Phase 1, Phase 2 Rovalpituzumab tesirine
5 Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Recruiting NCT03728361 Phase 2 Temozolomide
6 A GCO Trial Exploring the Efficacy and Safety of Nivolumab Monotherapy or Nivolumab Plus Ipilimumab in Pre-treated Patients With Advanced, Refractory Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Tumors (NECs) Not yet recruiting NCT03591731 Phase 2 Nivolumab;Ipilimumab
7 SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma Terminated NCT02500914 Phase 1 SC-002
8 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Large Cell Neuroendocrine Carcinoma

Genetic Tests for Large Cell Neuroendocrine Carcinoma

Anatomical Context for Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Large Cell Neuroendocrine Carcinoma:

41
Lung, Cervix, Ovary, Thymus, Colon, Prostate, Breast

Publications for Large Cell Neuroendocrine Carcinoma

Articles related to Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 407)
# Title Authors Year
1
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy. ( 29302900 )
2018
2
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
3
Large-cell neuroendocrine carcinoma arising in the endometrium: A case report. ( 29564132 )
2018
4
Esophageal Large-Cell Neuroendocrine Carcinoma with Inconsistent Response to Treatment in the Primary and Metastatic Lesions. ( 29928189 )
2018
5
Large-cell neuroendocrine carcinoma arising from a gastritis cystica polyposa. ( 29305822 )
2018
6
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
7
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
8
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review. ( 29458887 )
2018
9
Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection. ( 29954768 )
2018
10
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. ( 29466852 )
2018
11
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
12
Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status. ( 29581877 )
2018
13
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
14
The role of systemic therapy in the management of stage I large cell neuroendocrine carcinoma of the lung. ( 29391287 )
2018
15
PD-L1 expression in large cell neuroendocrine carcinoma of the lung. ( 29572007 )
2018
16
MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma. ( 29914531 )
2018
17
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2018
18
Primary large cell neuroendocrine carcinoma of the skin: An under-recognized entity and a mimic of metastatic disease. ( 28960456 )
2018
19
Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung. ( 29328464 )
2018
20
A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium. ( 30013803 )
2018
21
"Pure" High-Grade Large Cell Neuroendocrine Carcinoma Arising from Low- and High-Grade Dysplasia of the Gallbladder: Case Report and Review of the Literature. ( 30043226 )
2018
22
Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei. ( 30048995 )
2018
23
Large cell neuroendocrine carcinoma of the lung with atypical evolution and a remarkable response to lutetium Lu 177 dotatate. ( 30051167 )
2018
24
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )
2018
25
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature. ( 30191506 )
2018
26
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. ( 30197480 )
2018
27
Poorly differentiated large-cell neuroendocrine carcinoma of the paranasal sinus. ( 30202133 )
2018
28
Primary large cell neuroendocrine carcinoma of the prostate in a hormone naive patient: A case report from Taiwan. ( 30249904 )
2018
29
A rare case of de novo large cell neuroendocrine carcinoma of the prostate with long-term survival after cystoprostatectomy and androgen deprivation. ( 30263889 )
2018
30
Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy. ( 30333385 )
2018
31
Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms. ( 30374380 )
2018
32
Prognostic significance of PD-L1 expression and tumor infiltrating lymphocytes in large cell neuroendocrine carcinoma of lung. ( 30416665 )
2018
33
Resected thymic large cell neuroendocrine carcinoma: report of a case. ( 30446840 )
2018
34
Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity. ( 30455817 )
2018
35
Smear cytological features of large cell neuroendocrine carcinoma of the uterine cervix in pregnancy: A case report and review of the literature. ( 30461217 )
2018
36
Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report. ( 30483095 )
2018
37
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimen? ( 30485478 )
2018
38
External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? ( 28638669 )
2017
39
Protein induced by vitamin K absence or antagonist II (PIVKA-II) producing large cell neuroendocrine carcinoma (LCNEC) of lung with multiple liver metastases: A case report. ( 28075042 )
2017
40
Large cell neuroendocrine carcinoma of the kidney with cardiac metastasis: a case report. ( 29052535 )
2017
41
Update on large cell neuroendocrine carcinoma. ( 29114469 )
2017
42
Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. ( 29246628 )
2017
43
Pneumocystis Pneumonia Concomitant with Ectopic ACTH Syndrome Caused by a Large Cell Neuroendocrine Carcinoma of the Thymus. ( 28250304 )
2017
44
Amrubicin monotherapy may be an effective second-line treatment for patients with large-cell neuroendocrine carcinoma or high-grade non-small-cell neuroendocrine carcinoma. ( 28529747 )
2017
45
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. ( 28905513 )
2017
46
Histological Transformation to Large Cell Neuroendocrine Carcinoma from Lung Adenocarcinoma Harboring an EGFR Mutation: An Autopsy Case Report. ( 28768973 )
2017
47
Large Cell Neuroendocrine Carcinoma Transformation and EGFR-T790M Mutation as Coexisting Mechanisms of Acquired Resistance to EGFR-TKIs in Lung Cancer. ( 28778263 )
2017
48
Prognostic significance of neutrophil-lymphocyte ratios in large cell neuroendocrine carcinoma. ( 28766133 )
2017
49
Aggressive large-cell neuroendocrine carcinoma of the sigmoid colon in a patient with ulcerative colitis. ( 28790093 )
2017
50
A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission. ( 28560016 )
2017

Variations for Large Cell Neuroendocrine Carcinoma

Expression for Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Large Cell Neuroendocrine Carcinoma.

Pathways for Large Cell Neuroendocrine Carcinoma

Pathways related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 NCAM1 NKX2-1 SYP
2 10.7 ASCL1 NCAM1 SYP
3 10.48 EGFR NCAM1

GO Terms for Large Cell Neuroendocrine Carcinoma

Cellular components related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.62 CHGA KIT

Biological processes related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.61 ASCL1 EGFR KIT
2 oligodendrocyte differentiation GO:0048709 9.48 ASCL1 NKX2-1
3 neuron fate commitment GO:0048663 9.46 ASCL1 NKX2-1
4 mast cell degranulation GO:0043303 9.4 CHGA KIT
5 tongue development GO:0043586 9.37 EGFR KIT
6 cerebral cortex cell migration GO:0021795 9.32 EGFR NKX2-1
7 forebrain neuron differentiation GO:0021879 9.26 ASCL1 NKX2-1
8 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
9 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 ASCL1 NKX2-1
10 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 EGFR KIT NCAM1

Sources for Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....