MCID: LRG014
MIFTS: 37

Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Large Cell Neuroendocrine Carcinoma:

Name: Large Cell Neuroendocrine Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050872

Summaries for Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Large Cell Neuroendocrine Carcinoma is related to pulmonary large cell neuroendocrine carcinoma and ovarian large-cell neuroendocrine carcinoma. An important gene associated with Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Somatostatin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and colon, and related phenotype is normal.

Related Diseases for Large Cell Neuroendocrine Carcinoma

Diseases related to Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 pulmonary large cell neuroendocrine carcinoma 33.9 CHGA ENO2 SYP
2 ovarian large-cell neuroendocrine carcinoma 32.7 CHGA KRT20 KRT7 NCAM1 SYP
3 adenosquamous carcinoma 30.2 EGFR KRT7 NKX2-1
4 tubular adenocarcinoma 30.1 CHGA EGFR KRT20
5 spindle cell carcinoma 30.0 ENO2 KRT7 SYP
6 mucinous adenocarcinoma 29.8 EGFR KRT20 KRT7 NKX2-1
7 adenocarcinoma in situ 29.7 KRT20 KRT7
8 lung cancer susceptibility 3 29.6 EGFR KRT20 KRT7 NKX2-1
9 gastric squamous cell carcinoma 29.0 CHGA ENO2 NCAM1 SYP
10 teratoma 28.7 ENO2 KIT KRT7 NKX2-1 SYP
11 cystic teratoma 28.4 ENO2 KRT20 KRT7 NKX2-1 SYP
12 large cell carcinoma 27.5 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
13 lung cancer 25.6 ASCL1 CHGA EGFR ENO2 KIT KRT7
14 neuroendocrine tumor 25.5 ASCL1 CHGA ENO2 KRT20 KRT7 NCAM1
15 small cell carcinoma 25.1 ASCL1 CHGA EGFR ENO2 KIT KRT20
16 small cell cancer of the lung 24.5 ASCL1 CHGA EGFR ENO2 KIT KRT20
17 cervical large cell neuroendocrine carcinoma 12.3
18 lung combined large cell neuroendocrine carcinoma 12.3
19 breast large cell neuroendocrine carcinoma 12.2
20 thymus large cell carcinoma 11.5
21 acinar cell cystadenocarcinoma 10.9 CHGA SYP
22 peritoneal serous adenocarcinoma 10.9 CHGA SYP
23 cellular ependymoma 10.9 CHGA SYP
24 primary hepatic neuroendocrine carcinoma 10.9 CHGA SYP
25 gastrointestinal neuroendocrine tumor 10.9 CHGA SYP
26 chordoid meningioma 10.9 CHGA SYP
27 ovary neuroendocrine neoplasm 10.9 KRT7 SYP
28 mucinous adenofibroma 10.8 KRT7 SYP
29 benign breast adenomyoepithelioma 10.8 EGFR KRT7
30 pancreatoblastoma 10.8 CHGA SYP
31 embryoma 10.8 NKX2-1 SYP
32 ureter, cancer of 10.8 CHGA SYP
33 oncocytic breast carcinoma 10.8 EGFR KRT7
34 solid adenocarcinoma with mucin production 10.7 KRT7 NKX2-1
35 seminal vesicle tumor 10.7 KRT7 SYP
36 mixed type thymoma 10.7 KIT SYP
37 tanycytic ependymoma 10.7 CHGA SYP
38 non-functioning pancreatic endocrine tumor 10.7 CHGA SYP
39 ovarian germ cell teratoma 10.7 KRT7 NKX2-1
40 pleomorphic xanthoastrocytoma 10.7 CHGA SYP
41 ovarian germ cell cancer 10.7 KRT7 NKX2-1
42 papillary adenoma 10.7 KRT7 NKX2-1
43 fibrolamellar carcinoma 10.7 KRT7 SYP
44 jejunal cancer 10.7 KIT KRT7
45 pancreatic cystadenocarcinoma 10.7 CHGA SYP
46 cribriform carcinoma 10.7 KIT KRT7
47 perivascular epithelioid cell tumor 10.7 KIT SYP
48 malignant mixed mullerian tumor 10.7 KIT KRT7
49 binswanger's disease 10.7 CHGA SYP
50 cystic basal cell carcinoma 10.6 KRT20 KRT7

Graphical network of the top 20 diseases related to Large Cell Neuroendocrine Carcinoma:



Diseases related to Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Large Cell Neuroendocrine Carcinoma

MGI Mouse Phenotypes related to Large Cell Neuroendocrine Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 ASCL1 EGFR KIT NKX2-1 SYP VIL1

Drugs & Therapeutics for Large Cell Neuroendocrine Carcinoma

Drugs for Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1, Phase 2 38916-34-6, 51110-01-1 53481605
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5 Hormone Antagonists Phase 1, Phase 2
6 Hormones Phase 1, Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Antimitotic Agents Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2
11 Etoposide phosphate Phase 2
12 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Recruiting NCT02755675 Phase 2
2 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
3 Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Recruiting NCT02709889 Phase 1, Phase 2 Rovalpituzumab tesirine
4 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Not yet recruiting NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
5 SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma Recruiting NCT02500914 Phase 1 SC-002
6 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Large Cell Neuroendocrine Carcinoma

Genetic Tests for Large Cell Neuroendocrine Carcinoma

Anatomical Context for Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Large Cell Neuroendocrine Carcinoma:

41
Lung, Cervix, Colon, Ovary, Prostate, Thymus, Skin

Publications for Large Cell Neuroendocrine Carcinoma

Articles related to Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 315)
# Title Authors Year
1
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy. ( 29302900 )
2018
2
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
3
Large-cell neuroendocrine carcinoma arising in the endometrium: A case report. ( 29564132 )
2018
4
Esophageal Large-Cell Neuroendocrine Carcinoma with Inconsistent Response to Treatment in the Primary and Metastatic Lesions. ( 29928189 )
2018
5
Large-cell neuroendocrine carcinoma arising from a gastritis cystica polyposa. ( 29305822 )
2018
6
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
7
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
8
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review. ( 29458887 )
2018
9
Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection. ( 29954768 )
2018
10
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. ( 29466852 )
2018
11
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
12
Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status. ( 29581877 )
2018
13
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
14
The role of systemic therapy in the management of stage I large cell neuroendocrine carcinoma of the lung. ( 29391287 )
2018
15
PD-L1 expression in large cell neuroendocrine carcinoma of the lung. ( 29572007 )
2018
16
MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma. ( 29914531 )
2018
17
Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung. ( 29328464 )
2018
18
Primary large cell neuroendocrine carcinoma of the skin: An under-recognized entity and a mimic of metastatic disease. ( 28960456 )
2018
19
External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? ( 28638669 )
2017
20
Protein induced by vitamin K absence or antagonist II (PIVKA-II) producing large cell neuroendocrine carcinoma (LCNEC) of lung with multiple liver metastases: A case report. ( 28075042 )
2017
21
Large cell neuroendocrine carcinoma of the kidney with cardiac metastasis: a case report. ( 29052535 )
2017
22
Update on large cell neuroendocrine carcinoma. ( 29114469 )
2017
23
Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. ( 29246628 )
2017
24
Pneumocystis Pneumonia Concomitant with Ectopic ACTH Syndrome Caused by a Large Cell Neuroendocrine Carcinoma of the Thymus. ( 28250304 )
2017
25
Amrubicin monotherapy may be an effective second-line treatment for patients with large-cell neuroendocrine carcinoma or high-grade non-small-cell neuroendocrine carcinoma. ( 28529747 )
2017
26
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. ( 28905513 )
2017
27
Histological Transformation to Large Cell Neuroendocrine Carcinoma from Lung Adenocarcinoma Harboring an EGFR Mutation: An Autopsy Case Report. ( 28768973 )
2017
28
Large Cell Neuroendocrine Carcinoma Transformation and EGFR-T790M Mutation as Coexisting Mechanisms of Acquired Resistance to EGFR-TKIs in Lung Cancer. ( 28778263 )
2017
29
Prognostic significance of neutrophil-lymphocyte ratios in large cell neuroendocrine carcinoma. ( 28766133 )
2017
30
Aggressive large-cell neuroendocrine carcinoma of the sigmoid colon in a patient with ulcerative colitis. ( 28790093 )
2017
31
A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission. ( 28560016 )
2017
32
Therapeutic strategies and genetic profile comparisons in small cell carcinoma and large cell neuroendocrine carcinoma of the lung using next-generation sequencing. ( 29312580 )
2017
33
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
34
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
35
Thymic large cell neuroendocrine carcinoma - a rare and aggressive tumor: a case report. ( 28602157 )
2017
36
Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder. ( 28994275 )
2017
37
A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test. ( 29259654 )
2017
38
A Case of Large Cell Neuroendocrine Carcinoma Harboring an ALK Rearrangement with Response to Alectinib. ( 29151522 )
2017
39
Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are. ( 29074547 )
2017
40
Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. ( 28588782 )
2017
41
Report of two cases of large cell neuroendocrine carcinoma of duodenal ampulla with contrasting outcomes following pancreaticoduodenectomy according to the use of adjuvant chemotherapy. ( 28160741 )
2017
42
Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. ( 28566585 )
2017
43
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2017
44
Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden. ( 28923100 )
2017
45
A case of large cell neuroendocrine carcinoma of the stomach with multiple liver metastases. ( 27498936 )
2016
46
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
47
Large Cell Neuroendocrine Carcinoma of the Head and Neck: A Clinicopathologic Series of 10 Cases With an Emphasis on HPV Status. ( 26735857 )
2016
48
Treatment of lung large cell neuroendocrine carcinoma. ( 26943800 )
2016
49
Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon. ( 27034803 )
2016
50
Paranuclear dot-like pancytokeratin positivity and MLH1/PMS2 loss in large cell neuroendocrine carcinoma of the endometrium. ( 27780606 )
2016

Variations for Large Cell Neuroendocrine Carcinoma

Expression for Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Large Cell Neuroendocrine Carcinoma.

Pathways for Large Cell Neuroendocrine Carcinoma

Pathways related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 NCAM1 NKX2-1 SYP
2 10.7 ASCL1 NCAM1 SYP
3 10.48 EGFR NCAM1

GO Terms for Large Cell Neuroendocrine Carcinoma

Cellular components related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.62 CHGA KIT

Biological processes related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligodendrocyte differentiation GO:0048709 9.46 ASCL1 NKX2-1
2 neuron fate commitment GO:0048663 9.43 ASCL1 NKX2-1
3 mast cell degranulation GO:0043303 9.4 CHGA KIT
4 cerebral cortex cell migration GO:0021795 9.37 EGFR NKX2-1
5 tongue development GO:0043586 9.32 EGFR KIT
6 forebrain neuron differentiation GO:0021879 9.26 ASCL1 NKX2-1
7 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
8 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 ASCL1 NKX2-1
9 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 EGFR KIT NCAM1
2 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.62 EGFR KIT

Sources for Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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