MCID: LRG014
MIFTS: 43

Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Large Cell Neuroendocrine Carcinoma:

Name: Large Cell Neuroendocrine Carcinoma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050872
UMLS 74 C1265996

Summaries for Large Cell Neuroendocrine Carcinoma

Disease Ontology : 12 A lung large cell carcinoma that derives from neuroendocrine cells.

MalaCards based summary : Large Cell Neuroendocrine Carcinoma is related to pulmonary large cell neuroendocrine carcinoma and ovarian large-cell neuroendocrine carcinoma. An important gene associated with Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Developmental Biology and Neuroscience. The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and breast, and related phenotypes are cellular and nervous system

Related Diseases for Large Cell Neuroendocrine Carcinoma

Diseases related to Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 pulmonary large cell neuroendocrine carcinoma 34.3 CHGA ENO2 SYP
2 ovarian large-cell neuroendocrine carcinoma 33.8 CHGA KRT20 NCAM1 SYP
3 appendix adenocarcinoma 30.4 KRT20 KRT7
4 mucinous adenocarcinoma 30.1 EGFR KRT20 KRT7 NKX2-1
5 tubular adenocarcinoma 30.0 CHGA KRT20 SYP
6 adenosquamous carcinoma 30.0 EGFR KIT KRT7 NKX2-1
7 papillary carcinoma 29.9 KRT20 KRT7 NKX2-1
8 lung cancer susceptibility 3 29.6 EGFR KRT20 KRT7 NKX2-1
9 teratoma 29.6 ENO2 KIT KRT7 NKX2-1 SYP
10 gastric squamous cell carcinoma 29.4 CHGA ENO2 KRT7 NCAM1 SYP
11 cystic teratoma 29.3 ENO2 KRT20 KRT7 NKX2-1 SYP
12 large cell carcinoma 29.3 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
13 small cell carcinoma 29.1 CHGA EGFR ENO2 KIT KRT20 KRT7
14 lung cancer 28.3 ASCL1 CHGA EGFR ENO2 KIT KRT20
15 neuroendocrine tumor 28.2 ASCL1 CHGA ENO2 KRT20 KRT7 NCAM1
16 small cell cancer of the lung 28.0 ASCL1 CHGA EGFR ENO2 KIT KRT20
17 cervical large cell neuroendocrine carcinoma 12.6
18 lung combined large cell neuroendocrine carcinoma 12.5
19 breast large cell neuroendocrine carcinoma 12.4
20 thymus large cell carcinoma 11.7
21 neuroendocrine carcinoma 11.2
22 adenocarcinoma 10.6
23 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
24 anterior cranial fossa meningioma 10.5 CHGA SYP
25 pleomorphic xanthoastrocytoma 10.5 CHGA SYP
26 peritoneal serous adenocarcinoma 10.5 CHGA SYP
27 cellular ependymoma 10.5 CHGA SYP
28 tanycytic ependymoma 10.5 CHGA SYP
29 pancreatoblastoma 10.5 CHGA SYP
30 olfactory groove meningioma 10.5 CHGA SYP
31 non-functioning pancreatic endocrine tumor 10.5 CHGA SYP
32 chordoid meningioma 10.5 CHGA SYP
33 binswanger's disease 10.5 CHGA SYP
34 primary hepatic neuroendocrine carcinoma 10.5 CHGA SYP
35 seminal vesicle tumor 10.5 KRT7 SYP
36 perivascular epithelioid cell tumor 10.4 KIT SYP
37 mixed type thymoma 10.4 KIT SYP
38 oncocytic breast carcinoma 10.4 EGFR KRT7
39 functional colonic disease 10.4 KIT SYP
40 ovarian germ cell cancer 10.4 KRT7 NKX2-1
41 solid adenocarcinoma with mucin production 10.4 KRT7 NKX2-1
42 papillary adenoma 10.4 KRT7 NKX2-1
43 gastric cardia carcinoma 10.4 CHGA KIT
44 malignant leydig cell tumor 10.4 KIT KRT7
45 ovarian germ cell teratoma 10.4 KRT7 NKX2-1
46 alveoli adenoma 10.4 KRT7 NKX2-1
47 fibroepithelial basal cell carcinoma 10.4 CHGA KRT20
48 adenoid basal cell carcinoma 10.4 KIT KRT7
49 ureter small cell carcinoma 10.4 CHGA SYP
50 cribriform carcinoma 10.4 KIT KRT7

Graphical network of the top 20 diseases related to Large Cell Neuroendocrine Carcinoma:



Diseases related to Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Large Cell Neuroendocrine Carcinoma

MGI Mouse Phenotypes related to Large Cell Neuroendocrine Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 ASCL1 EGFR ENO2 KIT KRT7 NCAM1
2 nervous system MP:0003631 9.61 ASCL1 CHGA EGFR ENO2 KIT NCAM1
3 respiratory system MP:0005388 9.1 ASCL1 EGFR ENO2 KIT NEUROD1 NKX2-1

Drugs & Therapeutics for Large Cell Neuroendocrine Carcinoma

Drugs for Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
4
Somatostatin Approved, Investigational Phase 1, Phase 2 38916-34-6, 51110-01-1 53481605
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
8
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
9
Pembrolizumab Approved Phase 2 1374853-91-4
10 Etoposide phosphate Phase 2
11 Albumin-Bound Paclitaxel Phase 2
12 Topoisomerase Inhibitors Phase 2
13 Antimitotic Agents Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2
15 Hormones Phase 1, Phase 2
16 Hormone Antagonists Phase 1, Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Antibodies Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunoglobulins Phase 2
22 Alkylating Agents Phase 2
23 Antineoplastic Agents, Alkylating Phase 2
24 Immunologic Factors Phase 1, Phase 2
25 Immunoconjugates Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Recruiting NCT02755675 Phase 2
3 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
4 A GCO Trial Exploring the Efficacy and Safety of Nivolumab Monotherapy or Nivolumab Plus Ipilimumab in Pre-treated Patients With Advanced, Refractory Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Tumors (NECs) Recruiting NCT03591731 Phase 2 Nivolumab;Ipilimumab
5 Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors Recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate
6 Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Recruiting NCT03728361 Phase 2 Temozolomide
7 Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Active, not recruiting NCT02709889 Phase 1, Phase 2 Rovalpituzumab tesirine
8 Pembrolizumab With Chemotherapy in Metastatic or Unresectable High Grade Gastroenteropancreatic or Lung Neuroendocrine Carcinoma Not yet recruiting NCT03901378 Phase 2 Pembrolizumab
9 SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma Terminated NCT02500914 Phase 1 SC-002
10 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Large Cell Neuroendocrine Carcinoma

Genetic Tests for Large Cell Neuroendocrine Carcinoma

Anatomical Context for Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Large Cell Neuroendocrine Carcinoma:

42
Lung, Cervix, Breast, Prostate, Ovary, Colon, Thymus

Publications for Large Cell Neuroendocrine Carcinoma

Articles related to Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 429)
# Title Authors Year
1
Transformation of epidermal growth factor receptor T790M mutation-positive adenosquamous carcinoma of the lung to small cell carcinoma and large-cell neuroendocrine carcinoma following osimertinib therapy: an autopsy case report. ( 30828454 )
2019
2
Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma. ( 30793508 )
2019
3
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. ( 30863102 )
2019
4
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC). ( 30885341 )
2019
5
Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study. ( 30944773 )
2019
6
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis. ( 30965328 )
2019
7
Large cell neuroendocrine carcinoma of the endometrium: a report and review of the literature. ( 30976646 )
2019
8
Colorectal Large Cell Neuroendocrine Carcinoma with lymphoid stroma: further evidence confirming a unique sub-type associated with MLH-1/PMS2 protein loss, BRAF mutation, EBV-negativity and possible better prognosis. ( 30990915 )
2019
9
The demographic and treatment options for patients with large cell neuroendocrine carcinoma of the lung. ( 31087628 )
2019
10
Lung Large Cell Neuroendocrine Carcinoma: An Analysis of Patients from the Surveillance, Epidemiology, and End-Results (SEER) Database. ( 31095532 )
2019
11
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. ( 29466852 )
2019
12
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )
2019
13
Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy. ( 30333385 )
2019
14
Smear cytological features of large cell neuroendocrine carcinoma of the uterine cervix in pregnancy: A case report and review of the literature. ( 30461217 )
2019
15
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? ( 30485478 )
2019
16
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. ( 30591488 )
2019
17
Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab. ( 30642453 )
2019
18
Large cell neuroendocrine carcinoma of the uterine cervix. ( 30642849 )
2019
19
Pure large cell neuroendocrine carcinoma of ovary: A rare clinical entity. ( 30658028 )
2019
20
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. ( 30675274 )
2019
21
Management of brain metastases from large cell neuroendocrine carcinoma of the lung: improved outcomes with radiosurgery. ( 30732516 )
2019
22
Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. ( 30734490 )
2019
23
Large Cell Neuroendocrine Carcinoma Shares Similarity with Small Cell Carcinoma on the Basis of Clinical and Pathological Features. ( 30818166 )
2019
24
Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection. ( 29954768 )
2018
25
Large-cell neuroendocrine carcinoma arising from a gastritis cystica polyposa. ( 29305822 )
2018
26
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2018
27
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. ( 28905513 )
2018
28
Primary large cell neuroendocrine carcinoma of the skin: An under-recognized entity and a mimic of metastatic disease. ( 28960456 )
2018
29
Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder. ( 28994275 )
2018
30
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
31
Large Cell Neuroendocrine Carcinoma Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement with Response to Alectinib. ( 29151522 )
2018
32
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
33
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
34
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy. ( 29302900 )
2018
35
Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung. ( 29328464 )
2018
36
The Role of Systemic Therapy in the Management of Stage I Large Cell Neuroendocrine Carcinoma of the Lung. ( 29391287 )
2018
37
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
38
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review. ( 29458887 )
2018
39
Large-cell neuroendocrine carcinoma arising in the endometrium: A case report. ( 29564132 )
2018
40
PD-L1 expression in large cell neuroendocrine carcinoma of the lung. ( 29572007 )
2018
41
Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status. ( 29581877 )
2018
42
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
43
MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma. ( 29914531 )
2018
44
Esophageal Large-Cell Neuroendocrine Carcinoma with Inconsistent Response to Treatment in the Primary and Metastatic Lesions. ( 29928189 )
2018
45
A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium. ( 30013803 )
2018
46
"Pure" High-Grade Large Cell Neuroendocrine Carcinoma Arising from Low- and High-Grade Dysplasia of the Gallbladder: Case Report and Review of the Literature. ( 30043226 )
2018
47
Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei. ( 30048995 )
2018
48
Large cell neuroendocrine carcinoma of the lung with atypical evolution and a remarkable response to lutetium Lu 177 dotatate. ( 30051167 )
2018
49
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature. ( 30191506 )
2018
50
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. ( 30197480 )
2018

Variations for Large Cell Neuroendocrine Carcinoma

Expression for Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Large Cell Neuroendocrine Carcinoma.

Pathways for Large Cell Neuroendocrine Carcinoma

Pathways related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 EGFR KIT KRT20 KRT7 NCAM1 NEUROD1
2 11.89 ENO2 NCAM1 NEUROD1 NKX2-1 SYP
3 11.46 ASCL1 NCAM1 NEUROD1
4 10.82 ASCL1 NCAM1 NEUROD1 SYP
5 10.64 EGFR NCAM1

GO Terms for Large Cell Neuroendocrine Carcinoma

Cellular components related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.62 CHGA KIT

Biological processes related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.61 ASCL1 EGFR KIT
2 neuron fate commitment GO:0048663 9.46 ASCL1 NKX2-1
3 mast cell degranulation GO:0043303 9.4 CHGA KIT
4 tongue development GO:0043586 9.37 EGFR KIT
5 cerebral cortex cell migration GO:0021795 9.32 EGFR NKX2-1
6 forebrain neuron differentiation GO:0021879 9.26 ASCL1 NKX2-1
7 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
8 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 ASCL1 NKX2-1
9 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.8 ASCL1 EGFR NEUROD1

Sources for Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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