MCID: LRG014
MIFTS: 43

Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Large Cell Neuroendocrine Carcinoma:

Name: Large Cell Neuroendocrine Carcinoma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050872
UMLS 74 C1265996

Summaries for Large Cell Neuroendocrine Carcinoma

Disease Ontology : 12 A lung large cell carcinoma that derives from neuroendocrine cells.

MalaCards based summary : Large Cell Neuroendocrine Carcinoma is related to pulmonary large cell neuroendocrine carcinoma and ovarian large-cell neuroendocrine carcinoma. An important gene associated with Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Developmental Biology and Neuroscience. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and ovary, and related phenotypes are cellular and nervous system

Related Diseases for Large Cell Neuroendocrine Carcinoma

Diseases related to Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 pulmonary large cell neuroendocrine carcinoma 34.3 CHGA ENO2 SYP
2 ovarian large-cell neuroendocrine carcinoma 33.8 CHGA KRT20 NCAM1 SYP
3 mucinous adenocarcinoma 30.1 EGFR KRT20 KRT7 NKX2-1
4 tubular adenocarcinoma 30.0 CHGA KRT20 SYP
5 adenosquamous carcinoma 30.0 EGFR KIT KRT7 NKX2-1
6 papillary carcinoma 29.9 KRT20 KRT7 NKX2-1
7 lung cancer susceptibility 3 29.6 EGFR KRT20 KRT7 NKX2-1
8 teratoma 29.6 ENO2 KIT KRT7 NKX2-1 SYP
9 gastric squamous cell carcinoma 29.4 CHGA ENO2 KRT7 NCAM1 SYP
10 cystic teratoma 29.3 ENO2 KRT20 KRT7 NKX2-1 SYP
11 large cell carcinoma 29.3 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
12 small cell carcinoma 29.1 CHGA EGFR ENO2 KIT KRT20 KRT7
13 lung cancer 28.3 ASCL1 CHGA EGFR ENO2 KIT KRT20
14 neuroendocrine tumor 28.2 ASCL1 CHGA ENO2 KRT20 KRT7 NCAM1
15 small cell cancer of the lung 28.1 ASCL1 CHGA EGFR ENO2 KIT KRT20
16 cervical large cell neuroendocrine carcinoma 12.6
17 lung combined large cell neuroendocrine carcinoma 12.4
18 breast large cell neuroendocrine carcinoma 12.4
19 thymus large cell carcinoma 11.7
20 neuroendocrine carcinoma 11.2
21 adenocarcinoma 10.6
22 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
23 anterior cranial fossa meningioma 10.5 CHGA SYP
24 pleomorphic xanthoastrocytoma 10.5 CHGA SYP
25 peritoneal serous adenocarcinoma 10.5 CHGA SYP
26 cellular ependymoma 10.5 CHGA SYP
27 tanycytic ependymoma 10.5 CHGA SYP
28 pancreatoblastoma 10.5 CHGA SYP
29 olfactory groove meningioma 10.5 CHGA SYP
30 non-functioning pancreatic endocrine tumor 10.5 CHGA SYP
31 chordoid meningioma 10.5 CHGA SYP
32 binswanger's disease 10.5 CHGA SYP
33 primary hepatic neuroendocrine carcinoma 10.5 CHGA SYP
34 seminal vesicle tumor 10.4 KRT7 SYP
35 perivascular epithelioid cell tumor 10.4 KIT SYP
36 mixed type thymoma 10.4 KIT SYP
37 oncocytic breast carcinoma 10.4 EGFR KRT7
38 functional colonic disease 10.4 KIT SYP
39 ovarian germ cell cancer 10.4 KRT7 NKX2-1
40 solid adenocarcinoma with mucin production 10.4 KRT7 NKX2-1
41 papillary adenoma 10.4 KRT7 NKX2-1
42 gastric cardia carcinoma 10.4 CHGA KIT
43 malignant leydig cell tumor 10.4 KIT KRT7
44 ovarian germ cell teratoma 10.4 KRT7 NKX2-1
45 alveoli adenoma 10.4 KRT7 NKX2-1
46 fibroepithelial basal cell carcinoma 10.4 CHGA KRT20
47 adenoid basal cell carcinoma 10.4 KIT KRT7
48 ureter small cell carcinoma 10.4 CHGA SYP
49 cribriform carcinoma 10.4 KIT KRT7
50 spermatocele 10.4 NCAM1 SYP

Graphical network of the top 20 diseases related to Large Cell Neuroendocrine Carcinoma:



Diseases related to Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Large Cell Neuroendocrine Carcinoma

MGI Mouse Phenotypes related to Large Cell Neuroendocrine Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 ASCL1 EGFR ENO2 KIT KRT7 NCAM1
2 nervous system MP:0003631 9.61 ASCL1 CHGA EGFR ENO2 KIT NCAM1
3 respiratory system MP:0005388 9.1 ASCL1 EGFR ENO2 KIT NEUROD1 NKX2-1

Drugs & Therapeutics for Large Cell Neuroendocrine Carcinoma

Drugs for Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Somatostatin Approved, Investigational Phase 1, Phase 2 38916-34-6, 51110-01-1 53481605
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
8 Etoposide phosphate Phase 2
9 Topoisomerase Inhibitors Phase 2
10 Albumin-Bound Paclitaxel Phase 2
11 Antimitotic Agents Phase 2
12 Antineoplastic Agents, Phytogenic Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
14 Hormone Antagonists Phase 1, Phase 2
15 Hormones Phase 1, Phase 2
16 Antineoplastic Agents, Immunological Phase 2
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Immunoglobulins Phase 2
20 Immunoconjugates Phase 1, Phase 2
21 Immunologic Factors Phase 1, Phase 2
22 Alkylating Agents Phase 2
23 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Recruiting NCT02755675 Phase 2
3 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
4 Pembrolizumab With Chemotherapy in Metastatic or Unresectable High Grade Gastroenteropancreatic or Lung Neuroendocrine Carcinoma Not yet recruiting NCT03901378 Phase 2 Pembrolizumab
5 A GCO Trial Exploring the Efficacy and Safety of Nivolumab Monotherapy or Nivolumab Plus Ipilimumab in Pre-treated Patients With Advanced, Refractory Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Tumors (NECs) Recruiting NCT03591731 Phase 2 Nivolumab;Ipilimumab
6 Cabozantinib S-Malate, Nivolumab, and Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Not yet recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate
7 Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Active, not recruiting NCT02709889 Phase 1, Phase 2 Rovalpituzumab tesirine
8 Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Recruiting NCT03728361 Phase 2 Temozolomide
9 SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma Terminated NCT02500914 Phase 1 SC-002
10 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Large Cell Neuroendocrine Carcinoma

Genetic Tests for Large Cell Neuroendocrine Carcinoma

Anatomical Context for Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Large Cell Neuroendocrine Carcinoma:

42
Lung, Cervix, Ovary, Colon, Prostate, Breast, Brain

Publications for Large Cell Neuroendocrine Carcinoma

Articles related to Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 422)
# Title Authors Year
1
Transformation of epidermal growth factor receptor T790M mutation-positive adenosquamous carcinoma of the lung to small cell carcinoma and large-cell neuroendocrine carcinoma following osimertinib therapy: an autopsy case report. ( 30828454 )
2019
2
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )
2019
3
Smear cytological features of large cell neuroendocrine carcinoma of the uterine cervix in pregnancy: A case report and review of the literature. ( 30461217 )
2019
4
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. ( 30591488 )
2019
5
Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab. ( 30642453 )
2019
6
Large cell neuroendocrine carcinoma of the uterine cervix. ( 30642849 )
2019
7
Pure large cell neuroendocrine carcinoma of ovary: A rare clinical entity. ( 30658028 )
2019
8
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. ( 30675274 )
2019
9
Management of brain metastases from large cell neuroendocrine carcinoma of the lung: improved outcomes with radiosurgery. ( 30732516 )
2019
10
Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. ( 30734490 )
2019
11
Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma. ( 30793508 )
2019
12
Large Cell Neuroendocrine Carcinoma Shares Similarity with Small Cell Carcinoma on the Basis of Clinical and Pathological Features. ( 30818166 )
2019
13
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. ( 30863102 )
2019
14
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC). ( 30885341 )
2019
15
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy. ( 29302900 )
2018
16
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
17
Large-cell neuroendocrine carcinoma arising in the endometrium: A case report. ( 29564132 )
2018
18
Esophageal Large-Cell Neuroendocrine Carcinoma with Inconsistent Response to Treatment in the Primary and Metastatic Lesions. ( 29928189 )
2018
19
Large-cell neuroendocrine carcinoma arising from a gastritis cystica polyposa. ( 29305822 )
2018
20
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
21
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
22
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review. ( 29458887 )
2018
23
Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection. ( 29954768 )
2018
24
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. ( 29466852 )
2018
25
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
26
Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status. ( 29581877 )
2018
27
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
28
The role of systemic therapy in the management of stage I large cell neuroendocrine carcinoma of the lung. ( 29391287 )
2018
29
PD-L1 expression in large cell neuroendocrine carcinoma of the lung. ( 29572007 )
2018
30
MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma. ( 29914531 )
2018
31
Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung. ( 29328464 )
2018
32
Primary large cell neuroendocrine carcinoma of the skin: An under-recognized entity and a mimic of metastatic disease. ( 28960456 )
2018
33
A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium. ( 30013803 )
2018
34
"Pure" High-Grade Large Cell Neuroendocrine Carcinoma Arising from Low- and High-Grade Dysplasia of the Gallbladder: Case Report and Review of the Literature. ( 30043226 )
2018
35
Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei. ( 30048995 )
2018
36
Large cell neuroendocrine carcinoma of the lung with atypical evolution and a remarkable response to lutetium Lu 177 dotatate. ( 30051167 )
2018
37
Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature. ( 30191506 )
2018
38
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. ( 30197480 )
2018
39
Poorly differentiated large-cell neuroendocrine carcinoma of the paranasal sinus. ( 30202133 )
2018
40
Primary large cell neuroendocrine carcinoma of the prostate in a hormone naive patient: A case report from Taiwan. ( 30249904 )
2018
41
A rare case of de novo large cell neuroendocrine carcinoma of the prostate with long-term survival after cystoprostatectomy and androgen deprivation. ( 30263889 )
2018
42
Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy. ( 30333385 )
2018
43
Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms. ( 30374380 )
2018
44
Prognostic significance of PD-L1 expression and tumor infiltrating lymphocytes in large cell neuroendocrine carcinoma of lung. ( 30416665 )
2018
45
Resected thymic large cell neuroendocrine carcinoma: report of a case. ( 30446840 )
2018
46
Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity. ( 30455817 )
2018
47
Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report. ( 30483095 )
2018
48
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? ( 30485478 )
2018
49
Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report. ( 30572435 )
2018
50
Large Cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct. ( 30642152 )
2018

Variations for Large Cell Neuroendocrine Carcinoma

Expression for Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Large Cell Neuroendocrine Carcinoma.

Pathways for Large Cell Neuroendocrine Carcinoma

Pathways related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 EGFR KIT KRT20 KRT7 NCAM1 NEUROD1
2 11.89 ENO2 NCAM1 NEUROD1 NKX2-1 SYP
3 11.46 ASCL1 NCAM1 NEUROD1
4 10.82 ASCL1 NCAM1 NEUROD1 SYP
5 10.64 EGFR NCAM1

GO Terms for Large Cell Neuroendocrine Carcinoma

Cellular components related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.62 CHGA KIT

Biological processes related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.61 ASCL1 EGFR KIT
2 neuron fate commitment GO:0048663 9.46 ASCL1 NKX2-1
3 mast cell degranulation GO:0043303 9.4 CHGA KIT
4 tongue development GO:0043586 9.37 EGFR KIT
5 cerebral cortex cell migration GO:0021795 9.32 EGFR NKX2-1
6 forebrain neuron differentiation GO:0021879 9.26 ASCL1 NKX2-1
7 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
8 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 ASCL1 NKX2-1
9 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.13 ASCL1 EGFR NEUROD1
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 EGFR KIT NCAM1

Sources for Large Cell Neuroendocrine Carcinoma

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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