Large Intestine Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRG016 MIFTS: 36	Large Intestine Adenocarcinoma Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma ¹² ¹⁵

Adenocarcinoma of Large Intestine ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Gastrointestinal diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050913

UMLS ⁷¹ C1319315

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Summaries for Large Intestine Adenocarcinoma

Disease Ontology : ¹² A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and rare head and neck tumor. An important gene associated with Large Intestine Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. Affiliated tissues include colon and testes, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	27.9	TP53 SMAD4 PTEN PIK3CA KRAS HRAS
2	rare head and neck tumor	10.5	TP53 PIK3CA
3	prostate squamous cell carcinoma	10.4	TP53 HRAS
4	adult teratoma	10.4	TP53 HRAS
5	malignant anus melanoma	10.4	NRAS HRAS
6	malignant dermis tumor	10.4	NRAS HRAS
7	malignant skin fibrous histiocytoma	10.4	NRAS HRAS
8	vulvar intraepithelial neoplasia	10.4	TP53 CTNNB1
9	squamous cell papilloma	10.4	TP53 HRAS
10	vulvar melanoma	10.4	NRAS HRAS
11	central nervous system melanocytic neoplasm	10.4	NRAS HRAS
12	adult malignant schwannoma	10.3	TP53 HRAS
13	vulva squamous cell carcinoma	10.3	TP53 PIK3CA
14	glandular cystitis	10.3	TP53 CTNNB1
15	embryonal sarcoma	10.3	TP53 CTNNB1
16	gastric papillary adenocarcinoma	10.3	TP53 ERBB2
17	apocrine adenosis of breast	10.3	TP53 ERBB2
18	uterine adnexa cancer	10.3	TP53 PIK3CA
19	breast juvenile papillomatosis	10.3	PIK3CA ERBB2
20	breast papillary carcinoma	10.3	PIK3CA ERBB2
21	comedo carcinoma	10.3	TP53 ERBB2
22	parotid gland cancer	10.3	TP53 ERBB2
23	breast adenoid cystic carcinoma	10.3	TP53 ERBB2
24	pleomorphic adenoma carcinoma	10.3	TP53 ERBB2
25	autosomal dominant non-syndromic intellectual disability 19	10.3	SMAD4 CTNNB1
26	nephrogenic systemic fibrosis	10.3	SMAD4 PIK3CA
27	hyperplastic polyposis syndrome	10.3	TP53 KRAS
28	myoepithelial carcinoma	10.3	TP53 PIK3CA HRAS
29	localized osteosarcoma	10.3	TP53 ERBB2
30	ovarian benign neoplasm	10.3	TP53 HRAS
31	breast malignant phyllodes tumor	10.3	TP53 ERBB2
32	signet ring basal cell carcinoma	10.2	KRAS HRAS
33	hemimegalencephaly	10.2	PIK3CA CTNNB1
34	spitzoid melanoma	10.2	NRAS HRAS
35	apocrine adenocarcinoma	10.2	TP53 ERBB2
36	trachea carcinoma in situ	10.2	KRAS HRAS
37	cobblestone retinal degeneration	10.2	KRAS HRAS
38	nasal cavity adenocarcinoma	10.2	KRAS HRAS
39	nodular malignant melanoma	10.2	TP53 NRAS HRAS
40	melanocytic nevus syndrome, congenital	10.2	NRAS HRAS
41	liver angiosarcoma	10.2	TP53 KRAS
42	primary peritoneal carcinoma	10.2	TP53 ERBB2
43	ampulla of vater neoplasm	10.2	KRAS HRAS
44	granulosa cell tumor of the ovary	10.2	TP53 ERBB2
45	bone squamous cell carcinoma	10.2	TP53 CTNNB1
46	descending colon cancer	10.2	KRAS HRAS
47	gastric diffuse adenocarcinoma	10.2	TP53 ERBB2
48	periampullary adenoma	10.2	KRAS HRAS
49	melanoma in congenital melanocytic nevus	10.2	TP53 NRAS HRAS
50	clear cell adenocarcinoma	10.2	TP53 SMAD4 PIK3CA

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:

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Symptoms & Phenotypes for Large Intestine Adenocarcinoma

GenomeRNAi Phenotypes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 15)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.46	HRAS KRAS PIK3CA
2	Decreased viability	GR00055-A-2	10.46	HRAS KRAS PIK3CA
3	Decreased viability	GR00055-A-3	10.46	KRAS
4	Decreased viability	GR00106-A-0	10.46	KRAS
5	Decreased viability	GR00221-A-1	10.46	HRAS KRAS NRAS PIK3CA
6	Decreased viability	GR00221-A-2	10.46	HRAS KRAS PIK3CA
7	Decreased viability	GR00221-A-3	10.46	HRAS NRAS
8	Decreased viability	GR00221-A-4	10.46	PIK3CA
9	Decreased viability	GR00301-A	10.46	KRAS
10	Decreased viability	GR00381-A-1	10.46	KRAS
11	Decreased viability	GR00402-S-2	10.46	PIK3CA
12	Decreased cell migration	GR00055-A-3	9.62	HRAS PIK3CA
13	Increased cell death in HCT116 cells	GR00103-A-0	9.13	CTNNB1 FBXW7 PIK3CA
14	Decreased sensitivity to paclitaxel	GR00112-A-0	8.96	PTEN
15	Increased focal adhesion (FA) area, decreased number of small and round FAs, increased peripheral FA formation, increased cell spreading	GR00210-A	8.32	CTNNB1

MGI Mouse Phenotypes related to Large Intestine Adenocarcinoma:

⁴⁵ (show all 26)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.36	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
2	endocrine/exocrine gland	MP:0005379	10.33	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
3	cellular	MP:0005384	10.32	B2M CTNNB1 ERBB2 FBXW7 KRAS NRAS
4	growth/size/body region	MP:0005378	10.32	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
5	homeostasis/metabolism	MP:0005376	10.31	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
6	digestive/alimentary	MP:0005381	10.3	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
7	embryo	MP:0005380	10.3	B2M CTNNB1 ERBB2 FBXW7 KRAS NRAS
8	integument	MP:0010771	10.29	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
9	behavior/neurological	MP:0005386	10.28	CTNNB1 ERBB2 HRAS KRAS NRAS PIK3CA
10	mortality/aging	MP:0010768	10.25	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
11	neoplasm	MP:0002006	10.22	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
12	craniofacial	MP:0005382	10.21	CTNNB1 ERBB2 FBXW7 HRAS KRAS NRAS
13	immune system	MP:0005387	10.21	B2M CTNNB1 FBXW7 KRAS NRAS PIK3CA
14	hematopoietic system	MP:0005397	10.18	B2M CTNNB1 FBXW7 KRAS NRAS PTEN
15	nervous system	MP:0003631	10.16	B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
16	liver/biliary system	MP:0005370	10.13	B2M CTNNB1 FBXW7 KRAS NRAS PTEN
17	limbs/digits/tail	MP:0005371	10.08	CTNNB1 ERBB2 KRAS NRAS PTEN SMAD4
18	normal	MP:0002873	10.06	CTNNB1 ERBB2 FBXW7 HRAS KRAS NRAS
19	muscle	MP:0005369	10.04	CTNNB1 ERBB2 KRAS PIK3CA PTEN SMAD4
20	no phenotypic analysis	MP:0003012	9.91	CTNNB1 HRAS KRAS NRAS PIK3CA TP53
21	reproductive system	MP:0005389	9.86	B2M CTNNB1 ERBB2 KRAS PIK3CA PTEN
22	renal/urinary system	MP:0005367	9.8	CTNNB1 HRAS KRAS PTEN SMAD4 TP53
23	pigmentation	MP:0001186	9.77	CTNNB1 KRAS NRAS PTEN TP53
24	respiratory system	MP:0005388	9.7	CTNNB1 ERBB2 FBXW7 HRAS KRAS PTEN
25	skeleton	MP:0005390	9.61	CTNNB1 ERBB2 HRAS KRAS NRAS PIK3CA
26	vision/eye	MP:0005391	9.17	CTNNB1 FBXW7 KRAS NRAS PIK3CA PTEN

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Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

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Genetic Tests for Large Intestine Adenocarcinoma

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Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

⁴⁰

Colon, Testes

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Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 14)

#	Title	Authors	PMID	Year
1	In silico identification of putative roles of food-derived xeno-mirs on diet-associated cancer. ⁶¹	Pirim D...Dogan B	31584297	2020
2	Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. ⁶¹	Spuzak J...Nowak M	29166282	2017
3	Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. ⁶¹	Coco D...Boccoli G	25460441	2014
4	Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. ⁶¹	Sato T...Tamanoi F	20190810	2010
5	[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. ⁶¹	Magakian IuA...Ter-Pogosian ZP	19281045	2009
6	[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. ⁶¹	Karalova EM...Magakian IuA	16841493	2006
7	[Biologically active sphingolipids in transplantable tumors of different histogenesis]. ⁶¹	Kandyba AG...Diatlovskaia EV	16523727	2006
8	Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. ⁶¹	Dziegiel P...Zabel M	12647790	2003
9	Circadian rhythm of melatonin in patients with colorectal carcinoma. ⁶¹	Kos-Kudla B...Staszewicz P	12080285	2002
10	Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. ⁶¹	Ramalingam P...Goldblum JR	11473461	2001
11	[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. ⁶¹	Sun B...Zhao X	10072852	1997
12	Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. ⁶¹	Zoubek V...Zoubkova H	2245757	1990
13	[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. ⁶¹	Inoguchi T...Shinohara M	716804	1978
14	Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. ⁶¹	DIMMETTE RM...SPROAT HF	13302172	1956

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Genes for Large Intestine Adenocarcinoma

Genes related to Large Intestine Adenocarcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	13.84	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	12.65	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
3	SMAD4	SMAD Family Member 4	Protein Coding	12.19	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
4	CTNNB1	Catenin Beta 1	Protein Coding	12.09	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	11.96	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
6	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	11.85	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
7	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	8.75	GeneCards inferred via : Variants (show sections)
8	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	8.56	GeneCards inferred via : Variants (show sections)
9	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	8.37	GeneCards inferred via : Variants (show sections)
10	LRRC56	Leucine Rich Repeat Containing 56	Protein Coding	8.37	GeneCards inferred via : Variants (show sections)
11	B2M	Beta-2-Microglobulin	Protein Coding	8.08	GeneCards inferred via : Variants (show sections)
12	PTEN	Phosphatase And Tensin Homolog	Protein Coding	8.08	GeneCards inferred via : Variants (show sections)

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Variations for Large Intestine Adenocarcinoma

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Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

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Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 148)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	14.17	TP53 SMAD4 PTEN PIK3CA NRAS KRAS
2	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.03	TP53 PTEN PIK3CA NRAS KRAS HRAS
3	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.85	TP53 SMAD4 PTEN NRAS KRAS HRAS
4	HIV Life Cycle ⁶⁵ Show member pathways 2-LTR circle formation ⁶⁵ APOBEC3G mediated resistance to HIV-1 infection ⁶⁵ Assembly Of The HIV Virion ⁶⁵ Binding and entry of HIV virion ⁶⁵ Disease ⁶⁵ Diseases of signal transduction ⁶⁵ Early Phase of HIV Life Cycle ⁶⁵ HIV Infection ⁶⁵ Host Interactions of HIV factors ⁶⁵ Infectious disease ⁶⁵ Integration of provirus ⁶⁵ Late Phase of HIV Life Cycle ⁶⁵	13.74	SMAD4 PIK3CA NRAS KRAS HRAS FBXW7
5	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.57	TP53 SMAD4 PIK3CA NRAS KRAS HRAS
6	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.53	SMAD4 PIK3CA NRAS KRAS HRAS ERBB2
7	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.49	TP53 PTEN PIK3CA NRAS KRAS HRAS
8	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.43	TP53 PTEN NRAS KRAS HRAS ERBB2
9	Integrin Pathway ⁶³ Show member pathways FAK1 Signaling ⁶³ GnRH Signaling ⁶³ Inhibition of Angiogenesis by TSP1 ⁶³ Transendothelial Migration of Leukocytes ⁶³ UPA-UPAR Pathway ⁶³	13.42	PTEN PIK3CA NRAS KRAS HRAS CTNNB1
10	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.41	TP53 PIK3CA NRAS KRAS HRAS ERBB2
11	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.35	SMAD4 PTEN NRAS KRAS HRAS ERBB2
12	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.25	TP53 PTEN NRAS KRAS HRAS ERBB2
13	Parkinson disease ³⁶ Show member pathways Alzheimer disease ³⁶ Huntington disease ³⁶	13.22	TP53 PIK3CA NRAS KRAS HRAS CTNNB1
14	TNFR1 Pathway ⁶³ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶³ Apoptotic Pathways Triggered By HIV1 ⁶³ Death Receptor Signaling ⁶⁶ DR3 Signaling ⁶³ Fas Signaling ⁶³ GITR Pathway ⁶³ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁵ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶³ TNF Signaling ⁶⁶ TRAIL Pathway ⁶³ TWEAK Pathway ⁶³	13.13	TP53 PTEN PIK3CA NRAS KRAS HRAS
15	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.12	TP53 SMAD4 PIK3CA NRAS KRAS HRAS
16	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	13.09	TP53 PTEN NRAS KRAS HRAS
17	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.07	TP53 PTEN PIK3CA NRAS KRAS HRAS
18	fMLP Pathway ⁶³ Show member pathways Alpha-Adrenergic Signaling ⁶³ CCR3 Pathway in Eosinophils ⁶³ CXCR4 Pathway ⁶³ Huntington's Disease Pathway ⁶³ Internalin Pathway ⁶³ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶³	13.04	TP53 NRAS KRAS HRAS CTNNB1
19	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13.02	TP53 PIK3CA NRAS KRAS HRAS CTNNB1
20	Sertoli-Sertoli Cell Junction Dynamics ⁶³ Show member pathways Epithelial Tight Junctions ⁶³ Germ Cell-Sertoli Cell Junction Dynamics ⁶³	12.98	PTEN NRAS KRAS HRAS CTNNB1
21	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁶ IRS activation ⁶⁵ Signal attenuation ⁶⁵ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.98	PTEN PIK3CA NRAS KRAS HRAS ERBB2
22	Focal Adhesion ³⁶ ¹ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.98	PTEN PIK3CA NRAS KRAS HRAS ERBB2
23	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.94	PTEN PIK3CA NRAS KRAS HRAS ERBB2
24	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.87	PIK3CA NRAS KRAS HRAS
25	MAPK signaling pathway ³⁶ ¹	12.83	TP53 NRAS KRAS HRAS ERBB2
26	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.83	TP53 PTEN PIK3CA NRAS KRAS HRAS
27	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.83	TP53 SMAD4 PTEN PIK3CA NRAS KRAS
28	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.81	PIK3CA NRAS KRAS HRAS CTNNB1
29	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipocytokines and Insulin Signaling ⁶⁴ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²²	12.79	PTEN PIK3CA KRAS HRAS
30	Circadian entrainment ³⁶ Show member pathways Cholinergic synapse ³⁶ Dopaminergic synapse ³⁶ Glutamatergic synapse ³⁶ Synaptic Neurotransmission: Glutamatergic Excitation ⁶⁴	12.78	PIK3CA NRAS KRAS HRAS
31	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.78	TP53 PIK3CA NRAS KRAS HRAS
32	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.78	TP53 PTEN PIK3CA NRAS KRAS HRAS
33	Pathways in cancer ³⁶	12.78	TP53 SMAD4 PTEN PIK3CA NRAS KRAS
34	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.74	TP53 PTEN PIK3CA NRAS KRAS HRAS
35	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.73	TP53 PTEN PIK3CA NRAS KRAS HRAS
36	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.72	PIK3CA NRAS KRAS HRAS CTNNB1
37	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.7	PIK3CA NRAS KRAS HRAS
38	nNOS Signaling in Skeletal Muscle ⁶³ Show member pathways BMP Pathway ⁶³ Calpain Protease Regulates Cellular Mechanics ⁶³ Caspase Cascade ⁶³ Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels ⁶⁵ DREAM Repression and Dynorphin Expression ⁶³ TOB in Osteoblast Signaling ⁶³	12.7	SMAD4 NRAS KRAS HRAS
39	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.7	TP53 NRAS KRAS HRAS
40	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.7	TP53 PIK3CA NRAS KRAS HRAS ERBB2
41	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.69	PTEN PIK3CA NRAS KRAS HRAS
42	Regulation of actin cytoskeleton ³⁶ ¹	12.67	PIK3CA NRAS KRAS HRAS
43	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁶	12.67	PTEN PIK3CA NRAS KRAS HRAS
44	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.64	TP53 SMAD4 PTEN PIK3CA NRAS KRAS
45	MicroRNAs in cancer ³⁶	12.63	TP53 PTEN PIK3CA NRAS KRAS HRAS
46	Negative regulation of FGFR3 signaling ⁶⁵ Show member pathways FGFR1 ligand binding and activation ⁶⁵ FGFR1c ligand binding and activation ⁶⁵ FGFRL1 modulation of FGFR1 signaling ⁶⁵ Negative regulation of FGFR1 signaling ⁶⁵ Negative regulation of FGFR2 signaling ⁶⁵ Negative regulation of FGFR4 signaling ⁶⁵ Signaling by activated point mutants of FGFR1 ⁶⁵ Signaling by FGFR1 ⁶⁵ Signaling by FGFR3 ⁶⁵ Signaling by FGFR4 ⁶⁵ Spry regulation of FGF signaling ⁶⁵	12.61	PIK3CA NRAS KRAS HRAS
47	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.59	PTEN PIK3CA NRAS KRAS HRAS ERBB2
48	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling ⁶⁴	12.58	TP53 PTEN PIK3CA NRAS KRAS HRAS
49	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁶	12.57	PIK3CA NRAS KRAS HRAS
50	MET promotes cell motility ⁶⁵ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁵ MET activates PTK2 signaling ⁶⁵ MET activates RAP1 and RAC1 ⁶⁵ MET activates RAS signaling ⁶⁵ MET interacts with TNS proteins ⁶⁵ MET Receptor Activation ⁶⁵ MET receptor recycling ⁶⁵ Non-integrin membrane-ECM interactions ⁶⁵ Signaling by MET ⁶⁵ Syndecan interactions ⁶⁵	12.55	PIK3CA NRAS KRAS HRAS

Sources

GO Terms for Large Intestine Adenocarcinoma

Cellular components related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.32	TP53 SMAD4 PTEN PIK3CA KRAS HRAS

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.84	TP53 PTEN CTNNB1 B2M
2	negative regulation of gene expression	GO:0010629	9.83	TP53 HRAS FBXW7 CTNNB1
3	MAPK cascade	GO:0000165	9.8	NRAS KRAS HRAS ERBB2
4	positive regulation of cell proliferation	GO:0008284	9.8	PTEN KRAS HRAS ERBB2 CTNNB1
5	negative regulation of neuron apoptotic process	GO:0043524	9.79	PIK3CA KRAS HRAS
6	negative regulation of cell proliferation	GO:0008285	9.77	TP53 SMAD4 PTEN HRAS CTNNB1
7	heart development	GO:0007507	9.76	TP53 PTEN ERBB2 CTNNB1
8	positive regulation of MAPK cascade	GO:0043410	9.74	HRAS ERBB2 CTNNB1
9	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.72	NRAS KRAS HRAS
10	liver development	GO:0001889	9.69	PIK3CA KRAS HRAS
11	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.62	KRAS HRAS
12	positive regulation of cellular senescence	GO:2000774	9.61	KRAS B2M
13	positive regulation of ubiquitin-dependent protein catabolic process	GO:2000060	9.61	PTEN FBXW7
14	positive regulation of MAP kinase activity	GO:0043406	9.61	KRAS HRAS ERBB2
15	positive regulation of cardiac muscle cell apoptotic process	GO:0010666	9.6	TP53 PTEN
16	gastrulation with mouth forming second	GO:0001702	9.59	SMAD4 CTNNB1
17	epithelial tube branching involved in lung morphogenesis	GO:0060441	9.58	KRAS CTNNB1
18	positive regulation of histone H3-K4 methylation	GO:0051571	9.58	SMAD4 CTNNB1
19	regulation of synaptic transmission, GABAergic	GO:0032228	9.56	PTEN KRAS
20	phosphatidylinositol 3-kinase signaling	GO:0014065	9.5	PTEN PIK3CA ERBB2
21	response to isolation stress	GO:0035900	9.48	KRAS HRAS
22	T cell differentiation in thymus	GO:0033077	9.43	TP53 CTNNB1 B2M
23	positive regulation of gene expression	GO:0010628	9.43	TP53 PTEN KRAS HRAS ERBB2 CTNNB1
24	vasculature development	GO:0001944	9.33	PIK3CA FBXW7 CTNNB1
25	Ras protein signal transduction	GO:0007265	8.92	TP53 NRAS KRAS HRAS

Molecular functions related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.15	TP53 SMAD4 PTEN PIK3CA NRAS LRRC56
2	identical protein binding	GO:0042802	9.8	TP53 SMAD4 PTEN FBXW7 ERBB2 B2M
3	protein phosphatase binding	GO:0019903	9.33	TP53 ERBB2 CTNNB1
4	I-SMAD binding	GO:0070411	9.26	SMAD4 CTNNB1
5	GDP binding	GO:0019003	9.13	NRAS KRAS HRAS
6	RNA polymerase II transcription factor binding	GO:0001085	8.8	TP53 SMAD4 CTNNB1

Sources

Sources for Large Intestine Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia