MCID: LRG016
MIFTS: 36

Large Intestine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma 12 15
Adenocarcinoma of Large Intestine 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050913
UMLS 71 C1319315

Summaries for Large Intestine Adenocarcinoma

Disease Ontology : 12 A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and rare head and neck tumor. An important gene associated with Large Intestine Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. Affiliated tissues include colon and testes, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 27.9 TP53 SMAD4 PTEN PIK3CA KRAS HRAS
2 rare head and neck tumor 10.5 TP53 PIK3CA
3 prostate squamous cell carcinoma 10.4 TP53 HRAS
4 adult teratoma 10.4 TP53 HRAS
5 malignant anus melanoma 10.4 NRAS HRAS
6 malignant dermis tumor 10.4 NRAS HRAS
7 malignant skin fibrous histiocytoma 10.4 NRAS HRAS
8 vulvar intraepithelial neoplasia 10.4 TP53 CTNNB1
9 squamous cell papilloma 10.4 TP53 HRAS
10 vulvar melanoma 10.4 NRAS HRAS
11 central nervous system melanocytic neoplasm 10.4 NRAS HRAS
12 adult malignant schwannoma 10.3 TP53 HRAS
13 vulva squamous cell carcinoma 10.3 TP53 PIK3CA
14 glandular cystitis 10.3 TP53 CTNNB1
15 embryonal sarcoma 10.3 TP53 CTNNB1
16 gastric papillary adenocarcinoma 10.3 TP53 ERBB2
17 apocrine adenosis of breast 10.3 TP53 ERBB2
18 uterine adnexa cancer 10.3 TP53 PIK3CA
19 breast juvenile papillomatosis 10.3 PIK3CA ERBB2
20 breast papillary carcinoma 10.3 PIK3CA ERBB2
21 comedo carcinoma 10.3 TP53 ERBB2
22 parotid gland cancer 10.3 TP53 ERBB2
23 breast adenoid cystic carcinoma 10.3 TP53 ERBB2
24 pleomorphic adenoma carcinoma 10.3 TP53 ERBB2
25 autosomal dominant non-syndromic intellectual disability 19 10.3 SMAD4 CTNNB1
26 nephrogenic systemic fibrosis 10.3 SMAD4 PIK3CA
27 hyperplastic polyposis syndrome 10.3 TP53 KRAS
28 myoepithelial carcinoma 10.3 TP53 PIK3CA HRAS
29 localized osteosarcoma 10.3 TP53 ERBB2
30 ovarian benign neoplasm 10.3 TP53 HRAS
31 breast malignant phyllodes tumor 10.3 TP53 ERBB2
32 signet ring basal cell carcinoma 10.2 KRAS HRAS
33 hemimegalencephaly 10.2 PIK3CA CTNNB1
34 spitzoid melanoma 10.2 NRAS HRAS
35 apocrine adenocarcinoma 10.2 TP53 ERBB2
36 trachea carcinoma in situ 10.2 KRAS HRAS
37 cobblestone retinal degeneration 10.2 KRAS HRAS
38 nasal cavity adenocarcinoma 10.2 KRAS HRAS
39 nodular malignant melanoma 10.2 TP53 NRAS HRAS
40 melanocytic nevus syndrome, congenital 10.2 NRAS HRAS
41 liver angiosarcoma 10.2 TP53 KRAS
42 primary peritoneal carcinoma 10.2 TP53 ERBB2
43 ampulla of vater neoplasm 10.2 KRAS HRAS
44 granulosa cell tumor of the ovary 10.2 TP53 ERBB2
45 bone squamous cell carcinoma 10.2 TP53 CTNNB1
46 descending colon cancer 10.2 KRAS HRAS
47 gastric diffuse adenocarcinoma 10.2 TP53 ERBB2
48 periampullary adenoma 10.2 KRAS HRAS
49 melanoma in congenital melanocytic nevus 10.2 TP53 NRAS HRAS
50 clear cell adenocarcinoma 10.2 TP53 SMAD4 PIK3CA

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:



Diseases related to Large Intestine Adenocarcinoma

Symptoms & Phenotypes for Large Intestine Adenocarcinoma

GenomeRNAi Phenotypes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.46 HRAS KRAS PIK3CA
2 Decreased viability GR00055-A-2 10.46 HRAS KRAS PIK3CA
3 Decreased viability GR00055-A-3 10.46 KRAS
4 Decreased viability GR00106-A-0 10.46 KRAS
5 Decreased viability GR00221-A-1 10.46 HRAS KRAS NRAS PIK3CA
6 Decreased viability GR00221-A-2 10.46 HRAS KRAS PIK3CA
7 Decreased viability GR00221-A-3 10.46 HRAS NRAS
8 Decreased viability GR00221-A-4 10.46 PIK3CA
9 Decreased viability GR00301-A 10.46 KRAS
10 Decreased viability GR00381-A-1 10.46 KRAS
11 Decreased viability GR00402-S-2 10.46 PIK3CA
12 Decreased cell migration GR00055-A-3 9.62 HRAS PIK3CA
13 Increased cell death in HCT116 cells GR00103-A-0 9.13 CTNNB1 FBXW7 PIK3CA
14 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 PTEN
15 Increased focal adhesion (FA) area, decreased number of small and round FAs, increased peripheral FA formation, increased cell spreading GR00210-A 8.32 CTNNB1

MGI Mouse Phenotypes related to Large Intestine Adenocarcinoma:

45 (show all 26)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
2 endocrine/exocrine gland MP:0005379 10.33 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
3 cellular MP:0005384 10.32 B2M CTNNB1 ERBB2 FBXW7 KRAS NRAS
4 growth/size/body region MP:0005378 10.32 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
5 homeostasis/metabolism MP:0005376 10.31 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
6 digestive/alimentary MP:0005381 10.3 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
7 embryo MP:0005380 10.3 B2M CTNNB1 ERBB2 FBXW7 KRAS NRAS
8 integument MP:0010771 10.29 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
9 behavior/neurological MP:0005386 10.28 CTNNB1 ERBB2 HRAS KRAS NRAS PIK3CA
10 mortality/aging MP:0010768 10.25 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
11 neoplasm MP:0002006 10.22 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
12 craniofacial MP:0005382 10.21 CTNNB1 ERBB2 FBXW7 HRAS KRAS NRAS
13 immune system MP:0005387 10.21 B2M CTNNB1 FBXW7 KRAS NRAS PIK3CA
14 hematopoietic system MP:0005397 10.18 B2M CTNNB1 FBXW7 KRAS NRAS PTEN
15 nervous system MP:0003631 10.16 B2M CTNNB1 ERBB2 FBXW7 HRAS KRAS
16 liver/biliary system MP:0005370 10.13 B2M CTNNB1 FBXW7 KRAS NRAS PTEN
17 limbs/digits/tail MP:0005371 10.08 CTNNB1 ERBB2 KRAS NRAS PTEN SMAD4
18 normal MP:0002873 10.06 CTNNB1 ERBB2 FBXW7 HRAS KRAS NRAS
19 muscle MP:0005369 10.04 CTNNB1 ERBB2 KRAS PIK3CA PTEN SMAD4
20 no phenotypic analysis MP:0003012 9.91 CTNNB1 HRAS KRAS NRAS PIK3CA TP53
21 reproductive system MP:0005389 9.86 B2M CTNNB1 ERBB2 KRAS PIK3CA PTEN
22 renal/urinary system MP:0005367 9.8 CTNNB1 HRAS KRAS PTEN SMAD4 TP53
23 pigmentation MP:0001186 9.77 CTNNB1 KRAS NRAS PTEN TP53
24 respiratory system MP:0005388 9.7 CTNNB1 ERBB2 FBXW7 HRAS KRAS PTEN
25 skeleton MP:0005390 9.61 CTNNB1 ERBB2 HRAS KRAS NRAS PIK3CA
26 vision/eye MP:0005391 9.17 CTNNB1 FBXW7 KRAS NRAS PIK3CA PTEN

Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

Genetic Tests for Large Intestine Adenocarcinoma

Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

40
Colon, Testes

Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 14)
# Title Authors PMID Year
1
In silico identification of putative roles of food-derived xeno-mirs on diet-associated cancer. 61
31584297 2020
2
Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. 61
29166282 2017
3
Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. 61
25460441 2014
4
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. 61
20190810 2010
5
[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. 61
19281045 2009
6
[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. 61
16841493 2006
7
[Biologically active sphingolipids in transplantable tumors of different histogenesis]. 61
16523727 2006
8
Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. 61
12647790 2003
9
Circadian rhythm of melatonin in patients with colorectal carcinoma. 61
12080285 2002
10
Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. 61
11473461 2001
11
[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. 61
10072852 1997
12
Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. 61
2245757 1990
13
[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. 61
716804 1978
14
Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. 61
13302172 1956

Variations for Large Intestine Adenocarcinoma

Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 TP53 SMAD4 PTEN PIK3CA NRAS KRAS
2
Show member pathways
14.03 TP53 PTEN PIK3CA NRAS KRAS HRAS
3
Show member pathways
13.85 TP53 SMAD4 PTEN NRAS KRAS HRAS
4
Show member pathways
13.74 SMAD4 PIK3CA NRAS KRAS HRAS FBXW7
5
Show member pathways
13.57 TP53 SMAD4 PIK3CA NRAS KRAS HRAS
6
Show member pathways
13.53 SMAD4 PIK3CA NRAS KRAS HRAS ERBB2
7
Show member pathways
13.49 TP53 PTEN PIK3CA NRAS KRAS HRAS
8
Show member pathways
13.43 TP53 PTEN NRAS KRAS HRAS ERBB2
9
Show member pathways
13.42 PTEN PIK3CA NRAS KRAS HRAS CTNNB1
10
Show member pathways
13.41 TP53 PIK3CA NRAS KRAS HRAS ERBB2
11
Show member pathways
13.35 SMAD4 PTEN NRAS KRAS HRAS ERBB2
12
Show member pathways
13.25 TP53 PTEN NRAS KRAS HRAS ERBB2
13
Show member pathways
13.22 TP53 PIK3CA NRAS KRAS HRAS CTNNB1
14
Show member pathways
13.13 TP53 PTEN PIK3CA NRAS KRAS HRAS
15
Show member pathways
13.12 TP53 SMAD4 PIK3CA NRAS KRAS HRAS
16
Show member pathways
13.09 TP53 PTEN NRAS KRAS HRAS
17
Show member pathways
13.07 TP53 PTEN PIK3CA NRAS KRAS HRAS
18
Show member pathways
13.04 TP53 NRAS KRAS HRAS CTNNB1
19
Show member pathways
13.02 TP53 PIK3CA NRAS KRAS HRAS CTNNB1
20
Show member pathways
12.98 PTEN NRAS KRAS HRAS CTNNB1
21
Show member pathways
12.98 PTEN PIK3CA NRAS KRAS HRAS ERBB2
22
Show member pathways
12.98 PTEN PIK3CA NRAS KRAS HRAS ERBB2
23
Show member pathways
12.94 PTEN PIK3CA NRAS KRAS HRAS ERBB2
24
Show member pathways
12.87 PIK3CA NRAS KRAS HRAS
25 12.83 TP53 NRAS KRAS HRAS ERBB2
26
Show member pathways
12.83 TP53 PTEN PIK3CA NRAS KRAS HRAS
27
Show member pathways
12.83 TP53 SMAD4 PTEN PIK3CA NRAS KRAS
28
Show member pathways
12.81 PIK3CA NRAS KRAS HRAS CTNNB1
29
Show member pathways
12.79 PTEN PIK3CA KRAS HRAS
30
Show member pathways
12.78 PIK3CA NRAS KRAS HRAS
31
Show member pathways
12.78 TP53 PIK3CA NRAS KRAS HRAS
32
Show member pathways
12.78 TP53 PTEN PIK3CA NRAS KRAS HRAS
33 12.78 TP53 SMAD4 PTEN PIK3CA NRAS KRAS
34
Show member pathways
12.74 TP53 PTEN PIK3CA NRAS KRAS HRAS
35
Show member pathways
12.73 TP53 PTEN PIK3CA NRAS KRAS HRAS
36
Show member pathways
12.72 PIK3CA NRAS KRAS HRAS CTNNB1
37
Show member pathways
12.7 PIK3CA NRAS KRAS HRAS
38
Show member pathways
12.7 SMAD4 NRAS KRAS HRAS
39
Show member pathways
12.7 TP53 NRAS KRAS HRAS
40
Show member pathways
12.7 TP53 PIK3CA NRAS KRAS HRAS ERBB2
41
Show member pathways
12.69 PTEN PIK3CA NRAS KRAS HRAS
42 12.67 PIK3CA NRAS KRAS HRAS
43
Show member pathways
12.67 PTEN PIK3CA NRAS KRAS HRAS
44
Show member pathways
12.64 TP53 SMAD4 PTEN PIK3CA NRAS KRAS
45 12.63 TP53 PTEN PIK3CA NRAS KRAS HRAS
46
Show member pathways
12.61 PIK3CA NRAS KRAS HRAS
47
Show member pathways
12.59 PTEN PIK3CA NRAS KRAS HRAS ERBB2
48
Show member pathways
12.58 TP53 PTEN PIK3CA NRAS KRAS HRAS
49
Show member pathways
12.57 PIK3CA NRAS KRAS HRAS
50
Show member pathways
12.55 PIK3CA NRAS KRAS HRAS

GO Terms for Large Intestine Adenocarcinoma

Cellular components related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.32 TP53 SMAD4 PTEN PIK3CA KRAS HRAS

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.84 TP53 PTEN CTNNB1 B2M
2 negative regulation of gene expression GO:0010629 9.83 TP53 HRAS FBXW7 CTNNB1
3 MAPK cascade GO:0000165 9.8 NRAS KRAS HRAS ERBB2
4 positive regulation of cell proliferation GO:0008284 9.8 PTEN KRAS HRAS ERBB2 CTNNB1
5 negative regulation of neuron apoptotic process GO:0043524 9.79 PIK3CA KRAS HRAS
6 negative regulation of cell proliferation GO:0008285 9.77 TP53 SMAD4 PTEN HRAS CTNNB1
7 heart development GO:0007507 9.76 TP53 PTEN ERBB2 CTNNB1
8 positive regulation of MAPK cascade GO:0043410 9.74 HRAS ERBB2 CTNNB1
9 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.72 NRAS KRAS HRAS
10 liver development GO:0001889 9.69 PIK3CA KRAS HRAS
11 regulation of long-term neuronal synaptic plasticity GO:0048169 9.62 KRAS HRAS
12 positive regulation of cellular senescence GO:2000774 9.61 KRAS B2M
13 positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 9.61 PTEN FBXW7
14 positive regulation of MAP kinase activity GO:0043406 9.61 KRAS HRAS ERBB2
15 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.6 TP53 PTEN
16 gastrulation with mouth forming second GO:0001702 9.59 SMAD4 CTNNB1
17 epithelial tube branching involved in lung morphogenesis GO:0060441 9.58 KRAS CTNNB1
18 positive regulation of histone H3-K4 methylation GO:0051571 9.58 SMAD4 CTNNB1
19 regulation of synaptic transmission, GABAergic GO:0032228 9.56 PTEN KRAS
20 phosphatidylinositol 3-kinase signaling GO:0014065 9.5 PTEN PIK3CA ERBB2
21 response to isolation stress GO:0035900 9.48 KRAS HRAS
22 T cell differentiation in thymus GO:0033077 9.43 TP53 CTNNB1 B2M
23 positive regulation of gene expression GO:0010628 9.43 TP53 PTEN KRAS HRAS ERBB2 CTNNB1
24 vasculature development GO:0001944 9.33 PIK3CA FBXW7 CTNNB1
25 Ras protein signal transduction GO:0007265 8.92 TP53 NRAS KRAS HRAS

Molecular functions related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.15 TP53 SMAD4 PTEN PIK3CA NRAS LRRC56
2 identical protein binding GO:0042802 9.8 TP53 SMAD4 PTEN FBXW7 ERBB2 B2M
3 protein phosphatase binding GO:0019903 9.33 TP53 ERBB2 CTNNB1
4 I-SMAD binding GO:0070411 9.26 SMAD4 CTNNB1
5 GDP binding GO:0019003 9.13 NRAS KRAS HRAS
6 RNA polymerase II transcription factor binding GO:0001085 8.8 TP53 SMAD4 CTNNB1

Sources for Large Intestine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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