MCID: LRG016
MIFTS: 33

Large Intestine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma 12 15
Adenocarcinoma of Large Intestine 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050913
UMLS 72 C1319315

Summaries for Large Intestine Adenocarcinoma

Disease Ontology : 12 A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and rare adenocarcinoma of the breast. An important gene associated with Large Intestine Adenocarcinoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include colon and testes, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.3 TP53 PIK3CA ERBB2 CTNNB1
2 rare adenocarcinoma of the breast 10.3 TP53 PIK3CA
3 malignant spiradenoma 10.3 TP53 PIK3CA
4 anal squamous cell carcinoma 10.3 TP53 PIK3CA
5 female reproductive endometrioid cancer 10.3 TP53 CTNNB1
6 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.2 TP53 PIK3CA
7 esophageal basaloid squamous cell carcinoma 10.2 TP53 CTNNB1
8 embryonal sarcoma 10.2 TP53 CTNNB1
9 tongue disease 10.2 TP53 CTNNB1
10 acinar cell carcinoma 10.2 TP53 CTNNB1
11 prostate transitional cell carcinoma 10.2 PIK3CA CTNNB1
12 gastrointestinal system benign neoplasm 10.2 TP53 CTNNB1
13 intestinal benign neoplasm 10.2 TP53 CTNNB1
14 skin squamous cell carcinoma 10.2 TP53 PIK3CA
15 hemimegalencephaly 10.2 PIK3CA CTNNB1
16 gastric papillary adenocarcinoma 10.2 TP53 ERBB2
17 papillary adenocarcinoma 10.2 TP53 ERBB2
18 infratentorial cancer 10.2 TP53 CTNNB1
19 penile cancer 10.2 TP53 PIK3CA
20 pleomorphic adenoma carcinoma 10.2 TP53 ERBB2
21 pleomorphic adenoma 10.2 TP53 ERBB2
22 ovarian clear cell carcinoma 10.2 TP53 PIK3CA
23 non-proliferative fibrocystic change of the breast 10.2 TP53 ERBB2
24 nasopharyngeal disease 10.2 TP53 CTNNB1
25 microglandular adenosis 10.2 TP53 ERBB2
26 glioma susceptibility 1 10.2 TP53 ERBB2
27 brain stem glioma 10.2 TP53 PIK3CA
28 esophagus adenocarcinoma 10.2 TP53 ERBB2
29 atypical teratoid rhabdoid tumor 10.1 TP53 CTNNB1
30 thoracic benign neoplasm 10.1 TP53 ERBB2
31 breast benign neoplasm 10.1 TP53 ERBB2
32 pharynx cancer 10.1 TP53 CTNNB1
33 epstein-barr virus-associated gastric carcinoma 10.1 PIK3CA CTNNB1
34 hidradenocarcinoma 10.1 TP53 ERBB2
35 granulosa cell tumor of the ovary 10.1 TP53 ERBB2
36 adenosquamous carcinoma 10.1 TP53 PIK3CA
37 mixed cell type cancer 10.1 TP53 ERBB2
38 primary peritoneal carcinoma 10.1 TP53 ERBB2
39 cervix disease 10.1 TP53 CTNNB1
40 tonsil cancer 10.1 TP53 ERBB2
41 pre-malignant neoplasm 10.1 TP53 ERBB2
42 fallopian tube carcinoma 10.1 TP53 ERBB2
43 barrett's adenocarcinoma 10.1 TP53 ERBB2
44 cervical squamous cell carcinoma 10.1 TP53 CTNNB1
45 peutz-jeghers syndrome 10.1 TP53 CTNNB1
46 acneiform dermatitis 10.1 PIK3CA ERBB2
47 in situ carcinoma 10.1 TP53 ERBB2
48 lobular neoplasia 10.1 ERBB2 CTNNB1
49 breast carcinoma in situ 10.1 TP53 ERBB2
50 cell type benign neoplasm 10.1 TP53 CTNNB1

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:



Diseases related to Large Intestine Adenocarcinoma

Symptoms & Phenotypes for Large Intestine Adenocarcinoma

MGI Mouse Phenotypes related to Large Intestine Adenocarcinoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 CREBBP CTNNB1 ERBB2 PIK3CA TP53
2 cardiovascular system MP:0005385 9.93 CREBBP CTNNB1 ERBB2 PIK3CA TP53
3 cellular MP:0005384 9.92 CREBBP CTNNB1 ERBB2 PIK3CA TP53
4 embryo MP:0005380 9.88 CREBBP CTNNB1 ERBB2 PIK3CA TP53
5 endocrine/exocrine gland MP:0005379 9.85 CREBBP CTNNB1 ERBB2 PIK3CA TP53
6 growth/size/body region MP:0005378 9.83 CREBBP CTNNB1 ERBB2 PIK3CA TP53
7 craniofacial MP:0005382 9.81 CREBBP CTNNB1 ERBB2 TP53
8 digestive/alimentary MP:0005381 9.8 CREBBP CTNNB1 ERBB2 TP53
9 integument MP:0010771 9.8 CREBBP CTNNB1 ERBB2 PIK3CA TP53
10 muscle MP:0005369 9.72 CREBBP CTNNB1 ERBB2 PIK3CA TP53
11 limbs/digits/tail MP:0005371 9.67 CREBBP CTNNB1 ERBB2 TP53
12 neoplasm MP:0002006 9.65 CREBBP CTNNB1 ERBB2 PIK3CA TP53
13 nervous system MP:0003631 9.55 CREBBP CTNNB1 ERBB2 PIK3CA TP53
14 respiratory system MP:0005388 9.26 CREBBP CTNNB1 ERBB2 TP53
15 skeleton MP:0005390 9.02 CREBBP CTNNB1 ERBB2 PIK3CA TP53

Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

Genetic Tests for Large Intestine Adenocarcinoma

Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

41
Colon, Testes

Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 13)
# Title Authors PMID Year
1
Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. 38
29166282 2017
2
Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. 38
25460441 2014
3
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. 38
20190810 2010
4
[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. 38
19281045 2009
5
[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. 38
16841493 2006
6
[Biologically active sphingolipids in transplantable tumors of different histogenesis]. 38
16523727 2006
7
Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. 38
12647790 2003
8
Circadian rhythm of melatonin in patients with colorectal carcinoma. 38
12080285 2002
9
Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. 38
11473461 2001
10
[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. 38
10072852 1997
11
Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. 38
2245757 1990
12
[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. 38
716804 1978
13
Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. 38
13302172 1956

Variations for Large Intestine Adenocarcinoma

Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TP53 PIK3CA ERBB2 CTNNB1 CREBBP
2
Show member pathways
13.28 TP53 PIK3CA ERBB2 CREBBP
3
Show member pathways
13.24 PIK3CA ERBB2 CTNNB1 CREBBP
4
Show member pathways
12.72 TP53 PIK3CA CTNNB1 CREBBP
5
Show member pathways
12.71 TP53 PIK3CA CTNNB1 CREBBP
6
Show member pathways
12.68 PIK3CA ERBB2 CTNNB1
7
Show member pathways
12.65 PIK3CA ERBB2 CREBBP
8
Show member pathways
12.6 TP53 PIK3CA ERBB2 CTNNB1 CREBBP
9
Show member pathways
12.53 TP53 PIK3CA ERBB2
10
Show member pathways
12.53 TP53 PIK3CA ERBB2 CTNNB1
11
Show member pathways
12.49 TP53 PIK3CA ERBB2
12
Show member pathways
12.49 TP53 PIK3CA ERBB2 CTNNB1
13
Show member pathways
12.46 TP53 PIK3CA ERBB2 CTNNB1 CREBBP
14 12.38 TP53 PIK3CA ERBB2 CTNNB1 CREBBP
15
Show member pathways
12.34 TP53 PIK3CA ERBB2 CTNNB1
16
Show member pathways
12.33 TP53 PIK3CA ERBB2 CREBBP
17
Show member pathways
12.31 TP53 PIK3CA ERBB2
18
Show member pathways
12.29 PIK3CA ERBB2 CREBBP
19 12.29 TP53 PIK3CA ERBB2 CREBBP
20 12.23 TP53 CTNNB1 CREBBP
21
Show member pathways
12.19 PIK3CA ERBB2 CTNNB1
22
Show member pathways
12.18 TP53 PIK3CA ERBB2 CTNNB1
23
Show member pathways
12.14 PIK3CA ERBB2 CREBBP
24
Show member pathways
12.11 TP53 CTNNB1 CREBBP
25 12.11 TP53 PIK3CA CREBBP
26 12.07 TP53 PIK3CA CTNNB1 CREBBP
27
Show member pathways
12.02 TP53 PIK3CA ERBB2
28 12.01 TP53 PIK3CA ERBB2 CTNNB1
29 11.95 TP53 PIK3CA ERBB2
30
Show member pathways
11.94 PIK3CA ERBB2 CTNNB1
31 11.91 TP53 PIK3CA CTNNB1
32 11.86 TP53 CTNNB1 CREBBP
33
Show member pathways
11.85 TP53 PIK3CA ERBB2
34
Show member pathways
11.8 TP53 CTNNB1 CREBBP
35 11.79 PIK3CA ERBB2 CREBBP
36
Show member pathways
11.67 PIK3CA CREBBP
37 11.65 TP53 CREBBP
38 11.64 TP53 CREBBP
39 11.59 PIK3CA CTNNB1
40 11.59 TP53 ERBB2
41 11.59 TP53 PIK3CA ERBB2
42 11.58 ERBB2 CREBBP
43 11.56 ERBB2 CTNNB1 CREBBP
44 11.55 ERBB2 CTNNB1
45
Show member pathways
11.54 TP53 PIK3CA
46 11.54 TP53 PIK3CA ERBB2
47 11.53 TP53 PIK3CA CTNNB1 CREBBP
48 11.52 TP53 CTNNB1 CREBBP
49 11.48 TP53 CREBBP
50 11.48 CTNNB1 CREBBP

GO Terms for Large Intestine Adenocarcinoma

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.69 TP53 CTNNB1 CREBBP
2 positive regulation of gene expression GO:0010628 9.65 TP53 ERBB2 CTNNB1
3 negative regulation of apoptotic process GO:0043066 9.54 TP53 CTNNB1
4 cellular response to growth factor stimulus GO:0071363 9.52 ERBB2 CTNNB1
5 embryonic digit morphogenesis GO:0042733 9.49 CTNNB1 CREBBP
6 cellular response to UV GO:0034644 9.46 TP53 CREBBP
7 cell proliferation GO:0008283 9.43 TP53 CTNNB1
8 regulation of angiogenesis GO:0045765 9.4 ERBB2 CTNNB1
9 positive regulation of type I interferon production GO:0032481 9.37 CTNNB1 CREBBP
10 phosphatidylinositol 3-kinase signaling GO:0014065 9.32 PIK3CA ERBB2
11 ERBB2 signaling pathway GO:0038128 9.26 PIK3CA ERBB2
12 beta-catenin-TCF complex assembly GO:1904837 9.16 CTNNB1 CREBBP
13 regulation of apoptotic process GO:0042981 9.13 TP53 CTNNB1 CREBBP
14 vasculature development GO:0001944 8.62 PIK3CA CTNNB1

Molecular functions related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.63 TP53 ERBB2 CTNNB1
2 chromatin binding GO:0003682 9.54 TP53 CTNNB1 CREBBP
3 transcription factor binding GO:0008134 9.43 TP53 CTNNB1 CREBBP
4 p53 binding GO:0002039 9.4 TP53 CREBBP
5 RNA polymerase II activating transcription factor binding GO:0001102 9.32 CTNNB1 CREBBP
6 disordered domain specific binding GO:0097718 9.16 TP53 CTNNB1
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 PIK3CA
8 protein phosphatase binding GO:0019903 9.13 TP53 ERBB2 CTNNB1
9 RNA polymerase II transcription factor binding GO:0001085 8.8 TP53 CTNNB1 CREBBP

Sources for Large Intestine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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