Large Intestine Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma ¹² ¹⁵

Adenocarcinoma of Large Intestine ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Gastrointestinal diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050913

UMLS ⁷¹ C1319315

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Summaries for Large Intestine Adenocarcinoma

Disease Ontology : ¹² A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and gastric papillary adenocarcinoma. An important gene associated with Large Intestine Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include colon and testes.

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Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	30.4	TP53 SMAD4 RHOA ERBB2
2	gastric papillary adenocarcinoma	10.4	TP53 ERBB2
3	apocrine adenosis of breast	10.4	TP53 ERBB2
4	parotid gland cancer	10.4	TP53 ERBB2
5	tumor of exocrine pancreas	10.4	TP53 SMAD4
6	comedo carcinoma	10.4	TP53 ERBB2
7	pleomorphic adenoma carcinoma	10.4	TP53 ERBB2
8	breast malignant phyllodes tumor	10.4	TP53 ERBB2
9	breast sarcoma	10.4	TP53 ERBB2
10	ovarian carcinosarcoma	10.4	TP53 ERBB2
11	primary peritoneal carcinoma	10.4	TP53 ERBB2
12	urethra clear cell adenocarcinoma	10.4	TP53 SMAD4
13	biliary tract cancer	10.4	SMAD4 ERBB2
14	granulosa cell tumor of the ovary	10.4	TP53 ERBB2
15	gastric diffuse adenocarcinoma	10.3	TP53 ERBB2
16	intraductal breast neoplasm	10.3	TP53 ERBB2
17	rare carcinoma of pancreas	10.3	TP53 SMAD4
18	uterine corpus serous adenocarcinoma	10.3	TP53 ERBB2
19	sweat gland neoplasm	10.3	TP53 ERBB2
20	microglandular adenosis	10.3	TP53 ERBB2
21	vulvar disease	10.3	TP53 ERBB2
22	hypertrophy of breast	10.3	TP53 ERBB2
23	peritoneum cancer	10.3	TP53 ERBB2
24	xanthogranulomatous cholecystitis	10.3	TP53 CDO1
25	female reproductive endometrioid cancer	10.3	TP53 ERBB2
26	uterine body mixed cancer	10.2	TP53 ERBB2
27	adenosarcoma	10.2	TP53 ERBB2
28	ovarian cystadenocarcinoma	10.2	TP53 SMAD4 ERBB2
29	pancreatic ductal carcinoma	10.2	TP53 SMAD4 ERBB2
30	mature teratoma	10.2	TP53 ERBB2
31	small intestine cancer	10.2	TP53 SMAD4 ERBB2
32	ovary adenocarcinoma	10.2	TP53 SMAD4 ERBB2
33	duodenum disease	10.2	TP53 SMAD4
34	intrahepatic cholangiocarcinoma	10.2	TP53 SMAD4 ERBB2
35	cholangiocarcinoma	10.2	TP53 SMAD4 ERBB2
36	breast squamous cell carcinoma	10.2	TP53 RHOA ERBB2
37	ovarian serous cystadenocarcinoma	10.2	TP53 SMAD4 ERBB2
38	cowden syndrome	10.2	TP53 SMAD4 ERBB2
39	breast ductal carcinoma	10.1	TP53 SMAD4 ERBB2
40	barrett esophagus	10.1	TP53 SMAD4 ERBB2
41	contractures, pterygia, and variable skeletal fusions syndrome 1a	10.1	TP53 SMAD4 PTPN11
42	suppression of tumorigenicity 12	10.1	TP53 SMAD4 ERBB2
43	esophagus adenocarcinoma	10.1	TP53 ERBB2 CDO1
44	pigmented villonodular synovitis	10.1	TP53 PTPN11
45	gallbladder disease	10.0	TP53 ERBB2 CDO1
46	paget disease, extramammary	10.0	ERBB2 EBAG9
47	glioma susceptibility 1	10.0	TP53 PTPN11 ERBB2
48	sebaceous adenocarcinoma	10.0	TP53 ERBB2
49	squamous cell carcinoma	10.0	TP53 SMAD4 RHOA ERBB2
50	cervical adenocarcinoma	9.9	TP53 ERBB2 EBAG9

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:

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Symptoms & Phenotypes for Large Intestine Adenocarcinoma

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Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

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Genetic Tests for Large Intestine Adenocarcinoma

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Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

⁴⁰

Colon, Testes

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Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 14)

#	Title	Authors	PMID	Year
1	In silico identification of putative roles of food-derived xeno-mirs on diet-associated cancer. ⁶¹	Pirim D...Dogan B	31584297	2019
2	Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. ⁶¹	Spuzak J...Nowak M	29166282	2017
3	Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. ⁶¹	Coco D...Boccoli G	25460441	2014
4	Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. ⁶¹	Sato T...Tamanoi F	20190810	2010
5	[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. ⁶¹	Magakian IuA...Ter-Pogosian ZP	19281045	2009
6	[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. ⁶¹	Karalova EM...Magakian IuA	16841493	2006
7	[Biologically active sphingolipids in transplantable tumors of different histogenesis]. ⁶¹	Kandyba AG...Diatlovskaia EV	16523727	2006
8	Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. ⁶¹	Dziegiel P...Zabel M	12647790	2003
9	Circadian rhythm of melatonin in patients with colorectal carcinoma. ⁶¹	Kos-Kudla B...Staszewicz P	12080285	2002
10	Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. ⁶¹	Ramalingam P...Goldblum JR	11473461	2001
11	[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. ⁶¹	Sun B...Zhao X	10072852	1997
12	Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. ⁶¹	Zoubek V...Zoubkova H	2245757	1990
13	[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. ⁶¹	Inoguchi T...Shinohara M	716804	1978
14	Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. ⁶¹	DIMMETTE RM...SPROAT HF	13302172	1956

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Genes for Large Intestine Adenocarcinoma

Genes related to Large Intestine Adenocarcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	12.28	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	SMAD4	SMAD Family Member 4	Protein Coding	11.95	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
3	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	7.93	GeneCards inferred via : Variants (show sections)
4	RHOA	Ras Homolog Family Member A	Protein Coding	7.93	GeneCards inferred via : Variants (show sections)
5	XPO1	Exportin 1	Protein Coding	7.93	GeneCards inferred via : Variants (show sections)
6	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	7.38	GeneCards inferred via : Variants (show sections)
7	ANKRD18B	Ankyrin Repeat Domain 18B	Protein Coding	5.63	DISEASES inferred ¹⁵
8	CDO1	Cysteine Dioxygenase Type 1	Protein Coding	5.48	DISEASES inferred ¹⁵
9	TTC9	Tetratricopeptide Repeat Domain 9	Protein Coding	5.48	DISEASES inferred ¹⁵
10	EBAG9	Estrogen Receptor Binding Site Associated Antigen 9	Protein Coding	5.27	DISEASES inferred ¹⁵
11	DIPK2B	Divergent Protein Kinase Domain 2B	Protein Coding	5.12	DISEASES inferred ¹⁵
12	GPR52	G Protein-Coupled Receptor 52	Protein Coding	5.11	DISEASES inferred ¹⁵

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Variations for Large Intestine Adenocarcinoma

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Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

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Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.5	TP53 SMAD4 RHOA ERBB2
2	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.4	TP53 SMAD4 RHOA PTPN11 ERBB2
3	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.34	TP53 RHOA PTPN11 ERBB2
4	Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer ⁶⁵ Show member pathways Downregulation of SMAD2/3-SMAD4 transcriptional activity ⁶⁵ Interactions of Tat with host cellular proteins ⁶⁵ Signaling by TGF-beta Receptor Complex ⁶⁵ SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription ⁶⁵ TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) ⁶⁵	11.99	XPO1 SMAD4 RHOA
5	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	11.79	RHOA PTPN11 ERBB2
6	Proteoglycans in cancer ³⁶	11.77	TP53 RHOA PTPN11 ERBB2
7	TGF-beta Signaling Pathway (WikiPathways) ¹	11.67	TP53 SMAD4 RHOA
8	Transcription_P53 signaling pathway ²²	11.37	XPO1 TP53 SMAD4
9	Adherens junction ³⁶	11.35	SMAD4 RHOA ERBB2
10	DNA Damage Response (only ATM dependent) ¹	10.98	TP53 SMAD4 RHOA ERBB2
11	Extracellular vesicle-mediated signaling in recipient cells ¹	10.97	SMAD4 ERBB2
12	Hepatitis C and Hepatocellular Carcinoma ¹	10.84	TP53 SMAD4 PTPN11

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GO Terms for Large Intestine Adenocarcinoma

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.56	XPO1 TP53 RHOA GPR52
2	response to ethanol	GO:0045471	9.54	TP53 RHOA CDO1
3	transforming growth factor beta receptor signaling pathway	GO:0007179	9.5	TP53 SMAD4 RHOA
4	regulation of cell motility	GO:2000145	9.43	RHOA ERBB2
5	interleukin-6-mediated signaling pathway	GO:0070102	9.4	SMAD4 PTPN11
6	regulation of protein export from nucleus	GO:0046825	9.16	XPO1 PTPN11
7	atrioventricular canal development	GO:0036302	8.96	SMAD4 PTPN11
8	response to amino acid	GO:0043200	8.8	TP53 RHOA CDO1

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Sources for Large Intestine Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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³⁵ IUPHAR

³⁶ KEGG

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⁴⁰ MalaCards

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

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⁶⁷ SNOMED-CT

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⁶⁹ TGDB

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⁷⁴ Wikipedia