MCID: LRG016
MIFTS: 26

Large Intestine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma 12 15
Adenocarcinoma of Large Intestine 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050913
UMLS 71 C1319315

Summaries for Large Intestine Adenocarcinoma

Disease Ontology : 12 A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and gastric papillary adenocarcinoma. An important gene associated with Large Intestine Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include colon and testes.

Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.4 TP53 SMAD4 RHOA ERBB2
2 gastric papillary adenocarcinoma 10.4 TP53 ERBB2
3 apocrine adenosis of breast 10.4 TP53 ERBB2
4 parotid gland cancer 10.4 TP53 ERBB2
5 tumor of exocrine pancreas 10.4 TP53 SMAD4
6 comedo carcinoma 10.4 TP53 ERBB2
7 pleomorphic adenoma carcinoma 10.4 TP53 ERBB2
8 breast malignant phyllodes tumor 10.4 TP53 ERBB2
9 breast sarcoma 10.4 TP53 ERBB2
10 ovarian carcinosarcoma 10.4 TP53 ERBB2
11 primary peritoneal carcinoma 10.4 TP53 ERBB2
12 urethra clear cell adenocarcinoma 10.4 TP53 SMAD4
13 biliary tract cancer 10.4 SMAD4 ERBB2
14 granulosa cell tumor of the ovary 10.4 TP53 ERBB2
15 gastric diffuse adenocarcinoma 10.3 TP53 ERBB2
16 intraductal breast neoplasm 10.3 TP53 ERBB2
17 rare carcinoma of pancreas 10.3 TP53 SMAD4
18 uterine corpus serous adenocarcinoma 10.3 TP53 ERBB2
19 sweat gland neoplasm 10.3 TP53 ERBB2
20 microglandular adenosis 10.3 TP53 ERBB2
21 vulvar disease 10.3 TP53 ERBB2
22 hypertrophy of breast 10.3 TP53 ERBB2
23 peritoneum cancer 10.3 TP53 ERBB2
24 xanthogranulomatous cholecystitis 10.3 TP53 CDO1
25 female reproductive endometrioid cancer 10.3 TP53 ERBB2
26 uterine body mixed cancer 10.2 TP53 ERBB2
27 adenosarcoma 10.2 TP53 ERBB2
28 ovarian cystadenocarcinoma 10.2 TP53 SMAD4 ERBB2
29 pancreatic ductal carcinoma 10.2 TP53 SMAD4 ERBB2
30 mature teratoma 10.2 TP53 ERBB2
31 small intestine cancer 10.2 TP53 SMAD4 ERBB2
32 ovary adenocarcinoma 10.2 TP53 SMAD4 ERBB2
33 duodenum disease 10.2 TP53 SMAD4
34 intrahepatic cholangiocarcinoma 10.2 TP53 SMAD4 ERBB2
35 cholangiocarcinoma 10.2 TP53 SMAD4 ERBB2
36 breast squamous cell carcinoma 10.2 TP53 RHOA ERBB2
37 ovarian serous cystadenocarcinoma 10.2 TP53 SMAD4 ERBB2
38 cowden syndrome 10.2 TP53 SMAD4 ERBB2
39 breast ductal carcinoma 10.1 TP53 SMAD4 ERBB2
40 barrett esophagus 10.1 TP53 SMAD4 ERBB2
41 contractures, pterygia, and variable skeletal fusions syndrome 1a 10.1 TP53 SMAD4 PTPN11
42 suppression of tumorigenicity 12 10.1 TP53 SMAD4 ERBB2
43 esophagus adenocarcinoma 10.1 TP53 ERBB2 CDO1
44 pigmented villonodular synovitis 10.1 TP53 PTPN11
45 gallbladder disease 10.0 TP53 ERBB2 CDO1
46 paget disease, extramammary 10.0 ERBB2 EBAG9
47 glioma susceptibility 1 10.0 TP53 PTPN11 ERBB2
48 sebaceous adenocarcinoma 10.0 TP53 ERBB2
49 squamous cell carcinoma 10.0 TP53 SMAD4 RHOA ERBB2
50 cervical adenocarcinoma 9.9 TP53 ERBB2 EBAG9

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:



Diseases related to Large Intestine Adenocarcinoma

Symptoms & Phenotypes for Large Intestine Adenocarcinoma

Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

Genetic Tests for Large Intestine Adenocarcinoma

Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

40
Colon, Testes

Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 14)
# Title Authors PMID Year
1
In silico identification of putative roles of food-derived xeno-mirs on diet-associated cancer. 61
31584297 2019
2
Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. 61
29166282 2017
3
Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. 61
25460441 2014
4
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. 61
20190810 2010
5
[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. 61
19281045 2009
6
[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. 61
16841493 2006
7
[Biologically active sphingolipids in transplantable tumors of different histogenesis]. 61
16523727 2006
8
Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. 61
12647790 2003
9
Circadian rhythm of melatonin in patients with colorectal carcinoma. 61
12080285 2002
10
Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. 61
11473461 2001
11
[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. 61
10072852 1997
12
Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. 61
2245757 1990
13
[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. 61
716804 1978
14
Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. 61
13302172 1956

Variations for Large Intestine Adenocarcinoma

Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.5 TP53 SMAD4 RHOA ERBB2
2
Show member pathways
12.4 TP53 SMAD4 RHOA PTPN11 ERBB2
3
Show member pathways
12.34 TP53 RHOA PTPN11 ERBB2
4
Show member pathways
11.99 XPO1 SMAD4 RHOA
5
Show member pathways
11.79 RHOA PTPN11 ERBB2
6 11.77 TP53 RHOA PTPN11 ERBB2
7 11.67 TP53 SMAD4 RHOA
8 11.37 XPO1 TP53 SMAD4
9 11.35 SMAD4 RHOA ERBB2
10 10.98 TP53 SMAD4 RHOA ERBB2
11 10.97 SMAD4 ERBB2
12 10.84 TP53 SMAD4 PTPN11

GO Terms for Large Intestine Adenocarcinoma

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.56 XPO1 TP53 RHOA GPR52
2 response to ethanol GO:0045471 9.54 TP53 RHOA CDO1
3 transforming growth factor beta receptor signaling pathway GO:0007179 9.5 TP53 SMAD4 RHOA
4 regulation of cell motility GO:2000145 9.43 RHOA ERBB2
5 interleukin-6-mediated signaling pathway GO:0070102 9.4 SMAD4 PTPN11
6 regulation of protein export from nucleus GO:0046825 9.16 XPO1 PTPN11
7 atrioventricular canal development GO:0036302 8.96 SMAD4 PTPN11
8 response to amino acid GO:0043200 8.8 TP53 RHOA CDO1

Sources for Large Intestine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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