Large Intestine Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRG016 MIFTS: 33	Large Intestine Adenocarcinoma Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Large Intestine Adenocarcinoma

MalaCards integrated aliases for Large Intestine Adenocarcinoma:

Name: Large Intestine Adenocarcinoma ¹² ¹⁵

Adenocarcinoma of Large Intestine ⁷²

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Gastrointestinal diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050913

UMLS ⁷² C1319315

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Summaries for Large Intestine Adenocarcinoma

Disease Ontology : ¹² A large intestine cancer that has material basis in epithelial cells of glandular origin.

MalaCards based summary : Large Intestine Adenocarcinoma, also known as adenocarcinoma of large intestine, is related to adenocarcinoma and rare adenocarcinoma of the breast. An important gene associated with Large Intestine Adenocarcinoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include colon and testes, and related phenotypes are behavior/neurological and cardiovascular system

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Related Diseases for Large Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Large Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	29.3	TP53 PIK3CA ERBB2 CTNNB1
2	rare adenocarcinoma of the breast	10.3	TP53 PIK3CA
3	malignant spiradenoma	10.3	TP53 PIK3CA
4	anal squamous cell carcinoma	10.3	TP53 PIK3CA
5	female reproductive endometrioid cancer	10.3	TP53 CTNNB1
6	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	10.2	TP53 PIK3CA
7	esophageal basaloid squamous cell carcinoma	10.2	TP53 CTNNB1
8	embryonal sarcoma	10.2	TP53 CTNNB1
9	tongue disease	10.2	TP53 CTNNB1
10	acinar cell carcinoma	10.2	TP53 CTNNB1
11	prostate transitional cell carcinoma	10.2	PIK3CA CTNNB1
12	gastrointestinal system benign neoplasm	10.2	TP53 CTNNB1
13	intestinal benign neoplasm	10.2	TP53 CTNNB1
14	skin squamous cell carcinoma	10.2	TP53 PIK3CA
15	hemimegalencephaly	10.2	PIK3CA CTNNB1
16	gastric papillary adenocarcinoma	10.2	TP53 ERBB2
17	papillary adenocarcinoma	10.2	TP53 ERBB2
18	infratentorial cancer	10.2	TP53 CTNNB1
19	penile cancer	10.2	TP53 PIK3CA
20	pleomorphic adenoma carcinoma	10.2	TP53 ERBB2
21	pleomorphic adenoma	10.2	TP53 ERBB2
22	ovarian clear cell carcinoma	10.2	TP53 PIK3CA
23	non-proliferative fibrocystic change of the breast	10.2	TP53 ERBB2
24	nasopharyngeal disease	10.2	TP53 CTNNB1
25	microglandular adenosis	10.2	TP53 ERBB2
26	glioma susceptibility 1	10.2	TP53 ERBB2
27	brain stem glioma	10.2	TP53 PIK3CA
28	esophagus adenocarcinoma	10.2	TP53 ERBB2
29	atypical teratoid rhabdoid tumor	10.1	TP53 CTNNB1
30	thoracic benign neoplasm	10.1	TP53 ERBB2
31	breast benign neoplasm	10.1	TP53 ERBB2
32	pharynx cancer	10.1	TP53 CTNNB1
33	epstein-barr virus-associated gastric carcinoma	10.1	PIK3CA CTNNB1
34	hidradenocarcinoma	10.1	TP53 ERBB2
35	granulosa cell tumor of the ovary	10.1	TP53 ERBB2
36	adenosquamous carcinoma	10.1	TP53 PIK3CA
37	mixed cell type cancer	10.1	TP53 ERBB2
38	primary peritoneal carcinoma	10.1	TP53 ERBB2
39	cervix disease	10.1	TP53 CTNNB1
40	tonsil cancer	10.1	TP53 ERBB2
41	pre-malignant neoplasm	10.1	TP53 ERBB2
42	fallopian tube carcinoma	10.1	TP53 ERBB2
43	barrett's adenocarcinoma	10.1	TP53 ERBB2
44	cervical squamous cell carcinoma	10.1	TP53 CTNNB1
45	peutz-jeghers syndrome	10.1	TP53 CTNNB1
46	acneiform dermatitis	10.1	PIK3CA ERBB2
47	in situ carcinoma	10.1	TP53 ERBB2
48	lobular neoplasia	10.1	ERBB2 CTNNB1
49	breast carcinoma in situ	10.1	TP53 ERBB2
50	cell type benign neoplasm	10.1	TP53 CTNNB1

Graphical network of the top 20 diseases related to Large Intestine Adenocarcinoma:

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Symptoms & Phenotypes for Large Intestine Adenocarcinoma

MGI Mouse Phenotypes related to Large Intestine Adenocarcinoma:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.95	CREBBP CTNNB1 ERBB2 PIK3CA TP53
2	cardiovascular system	MP:0005385	9.93	CREBBP CTNNB1 ERBB2 PIK3CA TP53
3	cellular	MP:0005384	9.92	CREBBP CTNNB1 ERBB2 PIK3CA TP53
4	embryo	MP:0005380	9.88	CREBBP CTNNB1 ERBB2 PIK3CA TP53
5	endocrine/exocrine gland	MP:0005379	9.85	CREBBP CTNNB1 ERBB2 PIK3CA TP53
6	growth/size/body region	MP:0005378	9.83	CREBBP CTNNB1 ERBB2 PIK3CA TP53
7	craniofacial	MP:0005382	9.81	CREBBP CTNNB1 ERBB2 TP53
8	digestive/alimentary	MP:0005381	9.8	CREBBP CTNNB1 ERBB2 TP53
9	integument	MP:0010771	9.8	CREBBP CTNNB1 ERBB2 PIK3CA TP53
10	muscle	MP:0005369	9.72	CREBBP CTNNB1 ERBB2 PIK3CA TP53
11	limbs/digits/tail	MP:0005371	9.67	CREBBP CTNNB1 ERBB2 TP53
12	neoplasm	MP:0002006	9.65	CREBBP CTNNB1 ERBB2 PIK3CA TP53
13	nervous system	MP:0003631	9.55	CREBBP CTNNB1 ERBB2 PIK3CA TP53
14	respiratory system	MP:0005388	9.26	CREBBP CTNNB1 ERBB2 TP53
15	skeleton	MP:0005390	9.02	CREBBP CTNNB1 ERBB2 PIK3CA TP53

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Drugs & Therapeutics for Large Intestine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Large Intestine Adenocarcinoma

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Genetic Tests for Large Intestine Adenocarcinoma

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Anatomical Context for Large Intestine Adenocarcinoma

MalaCards organs/tissues related to Large Intestine Adenocarcinoma:

⁴¹

Colon, Testes

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Publications for Large Intestine Adenocarcinoma

Articles related to Large Intestine Adenocarcinoma:

(show all 13)

#	Title	Authors	PMID	Year
1	Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs - clinical, endoscopic, histopathological and immunohistochemical findings. ³⁸	Spuzak J...Nowak M	29166282	2017
2	Small bowel adenocarcinoma (SBA) three years after colonic adenocarcinoma in an elderly patient: Case report in a National Institute of Health and Aging (INRCA) and review of the literature. ³⁸	Coco D...Boccoli G	25460441	2014
3	Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. ³⁸	Sato T...Tamanoi F	20190810	2010
4	[Multiparametric study and cluster-analysis of the transformed cultures of human cells]. ³⁸	Magakian IuA...Ter-Pogosian ZP	19281045	2009
5	[Human large intestine adenocarcinoma cells (CaCo-2) in the process of cultivation]. ³⁸	Karalova EM...Magakian IuA	16841493	2006
6	[Biologically active sphingolipids in transplantable tumors of different histogenesis]. ³⁸	Kandyba AG...Diatlovskaia EV	16523727	2006
7	Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. ³⁸	Dziegiel P...Zabel M	12647790	2003
8	Circadian rhythm of melatonin in patients with colorectal carcinoma. ³⁸	Kos-Kudla B...Staszewicz P	12080285	2002
9	Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. ³⁸	Ramalingam P...Goldblum JR	11473461	2001
10	[Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. ³⁸	Sun B...Zhao X	10072852	1997
11	Results of screening for colorectal carcinoma in the District of Bruntál using the Haemoccult Test in 1985-1988. ³⁸	Zoubek V...Zoubkova H	2245757	1990
12	[Relationship between chronic schistosomiasis japonica and carcinoma in the large intestine.--Studies on 12 cases of adenocarcinoma of large intestine associated with eggs of Schistosoma japonicum (author's transl)]. ³⁸	Inoguchi T...Shinohara M	716804	1978
13	Relationship of schistosomiasis to polyposis and adenocarcinoma of large intestine. ³⁸	DIMMETTE RM...SPROAT HF	13302172	1956

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Genes for Large Intestine Adenocarcinoma

Genes related to Large Intestine Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CTNNB1	Catenin Beta 1	Protein Coding	20.42	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	TP53	Tumor Protein P53	Protein Coding	18.41	GeneCards inferred via : Variants (show sections)
3	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	18.24	GeneCards inferred via : Variants (show sections)
4	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	17.98	GeneCards inferred via : Variants (show sections)
5	CREBBP	CREB Binding Protein	Protein Coding	17.78	GeneCards inferred via : Variants (show sections)

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Variations for Large Intestine Adenocarcinoma

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Expression for Large Intestine Adenocarcinoma

Search GEO for disease gene expression data for Large Intestine Adenocarcinoma.

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Pathways for Large Intestine Adenocarcinoma

Pathways related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.72	TP53 PIK3CA ERBB2 CTNNB1 CREBBP
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.28	TP53 PIK3CA ERBB2 CREBBP
3	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.24	PIK3CA ERBB2 CTNNB1 CREBBP
4	Human cytomegalovirus infection ³⁷ Show member pathways Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	12.72	TP53 PIK3CA CTNNB1 CREBBP
5	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.71	TP53 PIK3CA CTNNB1 CREBBP
6	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.68	PIK3CA ERBB2 CTNNB1
7	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.65	PIK3CA ERBB2 CREBBP
8	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.6	TP53 PIK3CA ERBB2 CTNNB1 CREBBP
9	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.53	TP53 PIK3CA ERBB2
10	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.53	TP53 PIK3CA ERBB2 CTNNB1
11	Glioma ³⁷ Show member pathways Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.49	TP53 PIK3CA ERBB2
12	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.49	TP53 PIK3CA ERBB2 CTNNB1
13	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.46	TP53 PIK3CA ERBB2 CTNNB1 CREBBP
14	Pathways in cancer ³⁷	12.38	TP53 PIK3CA ERBB2 CTNNB1 CREBBP
15	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.34	TP53 PIK3CA ERBB2 CTNNB1
16	ErbB signaling pathway ³⁷ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ EGFR tyrosine kinase inhibitor resistance ³⁷ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.33	TP53 PIK3CA ERBB2 CREBBP
17	mTOR signaling pathway (KEGG) ³⁷ Show member pathways mTOR Signaling Pathway ⁶⁵	12.31	TP53 PIK3CA ERBB2
18	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.29	PIK3CA ERBB2 CREBBP
19	MicroRNAs in cancer ³⁷	12.29	TP53 PIK3CA ERBB2 CREBBP
20	WNT Signaling ⁶⁴	12.23	TP53 CTNNB1 CREBBP
21	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.19	PIK3CA ERBB2 CTNNB1
22	Apoptosis Pathway ⁷¹ Show member pathways Akt Pathway ⁷¹ NF-kappaB Pathway ⁷¹	12.18	TP53 PIK3CA ERBB2 CTNNB1
23	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.14	PIK3CA ERBB2 CREBBP
24	Wnt Signaling Pathway and Pluripotency ¹ Show member pathways Wnt Signaling Pathway ¹	12.11	TP53 CTNNB1 CREBBP
25	Viral carcinogenesis ³⁷	12.11	TP53 PIK3CA CREBBP
26	Human T-cell leukemia virus 1 infection ³⁷	12.07	TP53 PIK3CA CTNNB1 CREBBP
27	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.02	TP53 PIK3CA ERBB2
28	Proteoglycans in cancer ³⁷	12.01	TP53 PIK3CA ERBB2 CTNNB1
29	AKT Signaling Pathway ⁶⁷	11.95	TP53 PIK3CA ERBB2
30	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	11.94	PIK3CA ERBB2 CTNNB1
31	Fluid shear stress and atherosclerosis ³⁷	11.91	TP53 PIK3CA CTNNB1
32	SMAD Signaling Network ⁶⁴	11.86	TP53 CTNNB1 CREBBP
33	MAPK Pathway ⁷¹ Show member pathways Toll-like Receptor Pathway ⁷¹	11.85	TP53 PIK3CA ERBB2
34	Cell cycle Cell cycle (generic schema) ²² Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²² G0 and Early G1 ⁶⁶ G2 Phase ⁶⁶	11.8	TP53 CTNNB1 CREBBP
35	HIF-1 signaling pathway ³⁷	11.79	PIK3CA ERBB2 CREBBP
36	IL-6 signaling pathway ¹ Show member pathways IL6-mediated signaling events ¹	11.67	PIK3CA CREBBP
37	Glucocorticoid receptor regulatory network ¹	11.65	TP53 CREBBP
38	Validated targets of C-MYC transcriptional activation ¹	11.64	TP53 CREBBP
39	Bacterial invasion of epithelial cells ³⁷	11.59	PIK3CA CTNNB1
40	Bladder cancer ³⁷ ¹	11.59	TP53 ERBB2
41	Platinum drug resistance ³⁷	11.59	TP53 PIK3CA ERBB2
42	Development_TGF-beta receptor signaling ²²	11.58	ERBB2 CREBBP
43	Adherens junction ³⁷	11.56	ERBB2 CTNNB1 CREBBP
44	Association Between Physico-Chemical Features and Toxicity Associated Pathways ¹	11.55	ERBB2 CTNNB1
45	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁶ NFG and proNGF binds to p75NTR ⁶⁶	11.54	TP53 PIK3CA
46	Central carbon metabolism in cancer ³⁷	11.54	TP53 PIK3CA ERBB2
47	Thyroid hormone signaling pathway ³⁷	11.53	TP53 PIK3CA CTNNB1 CREBBP
48	Transcription_P53 signaling pathway ²²	11.52	TP53 CTNNB1 CREBBP
49	p53 pathway ¹	11.48	TP53 CREBBP
50	TGF-beta Receptor Signaling (WikiPathways) ¹	11.48	CTNNB1 CREBBP

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GO Terms for Large Intestine Adenocarcinoma

Biological processes related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	viral process	GO:0016032	9.69	TP53 CTNNB1 CREBBP
2	positive regulation of gene expression	GO:0010628	9.65	TP53 ERBB2 CTNNB1
3	negative regulation of apoptotic process	GO:0043066	9.54	TP53 CTNNB1
4	cellular response to growth factor stimulus	GO:0071363	9.52	ERBB2 CTNNB1
5	embryonic digit morphogenesis	GO:0042733	9.49	CTNNB1 CREBBP
6	cellular response to UV	GO:0034644	9.46	TP53 CREBBP
7	cell proliferation	GO:0008283	9.43	TP53 CTNNB1
8	regulation of angiogenesis	GO:0045765	9.4	ERBB2 CTNNB1
9	positive regulation of type I interferon production	GO:0032481	9.37	CTNNB1 CREBBP
10	phosphatidylinositol 3-kinase signaling	GO:0014065	9.32	PIK3CA ERBB2
11	ERBB2 signaling pathway	GO:0038128	9.26	PIK3CA ERBB2
12	beta-catenin-TCF complex assembly	GO:1904837	9.16	CTNNB1 CREBBP
13	regulation of apoptotic process	GO:0042981	9.13	TP53 CTNNB1 CREBBP
14	vasculature development	GO:0001944	8.62	PIK3CA CTNNB1

Molecular functions related to Large Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterodimerization activity	GO:0046982	9.63	TP53 ERBB2 CTNNB1
2	chromatin binding	GO:0003682	9.54	TP53 CTNNB1 CREBBP
3	transcription factor binding	GO:0008134	9.43	TP53 CTNNB1 CREBBP
4	p53 binding	GO:0002039	9.4	TP53 CREBBP
5	RNA polymerase II activating transcription factor binding	GO:0001102	9.32	CTNNB1 CREBBP
6	disordered domain specific binding	GO:0097718	9.16	TP53 CTNNB1
7	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.13	PIK3CA
8	protein phosphatase binding	GO:0019903	9.13	TP53 ERBB2 CTNNB1
9	RNA polymerase II transcription factor binding	GO:0001085	8.8	TP53 CTNNB1 CREBBP

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Sources for Large Intestine Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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¹⁰ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

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²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

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³³ ICD10

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³⁶ IUPHAR

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⁴¹ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

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⁵⁹ Orphanet

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⁶¹ PharmGKB

⁶² PubMed

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

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⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia