MCID: LRG015
MIFTS: 22

Large Intestine Adenoma

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Large Intestine Adenoma

MalaCards integrated aliases for Large Intestine Adenoma:

Name: Large Intestine Adenoma 11 14
Adenoma of Large Intestine 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0050914
UMLS 71 C1302401

Summaries for Large Intestine Adenoma

Disease Ontology: 11 An intestinal benign neoplasm that has material basis in epithelial tissue with glandular origin and is located in the large intestine.

MalaCards based summary: Large Intestine Adenoma, also known as adenoma of large intestine, is related to anismus and alveolar echinococcosis. An important gene associated with Large Intestine Adenoma is GUCA2A (Guanylate Cyclase Activator 2A), and among its related pathways/superpathways are Breast cancer pathway and Neural crest differentiation. The drugs Levoleucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include large intestine, and related phenotype is hearing/vestibular/ear.

Related Diseases for Large Intestine Adenoma

Diseases related to Large Intestine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 anismus 10.0 GUCY2C GUCA2A
2 alveolar echinococcosis 9.9 CES2 CES1
3 taeniasis 9.9 CES2 CES1
4 cystic echinococcosis 9.9 CES2 CES1
5 secretory diarrhea 9.9 GUCY2C GUCA2A
6 cysticercosis 9.9 CES2 CES1
7 parasitic helminthiasis infectious disease 9.7 CES2 CES1
8 alagille syndrome 1 9.5 HES5 DLL3

Graphical network of the top 20 diseases related to Large Intestine Adenoma:



Diseases related to Large Intestine Adenoma

Symptoms & Phenotypes for Large Intestine Adenoma

MGI Mouse Phenotypes related to Large Intestine Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 8.92 APC CES1 DLL3 HES5

Drugs & Therapeutics for Large Intestine Adenoma

Drugs for Large Intestine Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Experimental, Investigational 68538-85-2, 58-05-9, 73951-54-9 149436 6006
2
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
3 Vitamins
4 Folate
5 Vitamin B9
6 Trace Elements
7 Vitamin B Complex
8 Hematinics
9 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Versus Only Withdrawal of Colonoscopy: a Randomized, Controlled Trial Completed NCT01925833
2 The Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) Folic Acid Prevention Trial Completed NCT00512850

Search NIH Clinical Center for Large Intestine Adenoma

Genetic Tests for Large Intestine Adenoma

Anatomical Context for Large Intestine Adenoma

Organs/tissues related to Large Intestine Adenoma:

FMA: Large Intestine

Publications for Large Intestine Adenoma

Articles related to Large Intestine Adenoma:

# Title Authors PMID Year
1
Does human papilloma virus participate in colorectal carcinogenesis? 62
23241125 2012
2
[Colonoscopy monitoring intervals after polypectomy of adenomas of the large intestine in patients younger than 40 years of age]. 62
7812850 1994

Variations for Large Intestine Adenoma

Expression for Large Intestine Adenoma

Search GEO for disease gene expression data for Large Intestine Adenoma.

Pathways for Large Intestine Adenoma

GO Terms for Large Intestine Adenoma

Biological processes related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell differentiation GO:0045595 8.92 HES5 APC

Molecular functions related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic ester hydrolase activity GO:0052689 9.46 CES2 CES1
2 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.26 CES2 CES1
3 methyl indole-3-acetate esterase activity GO:0080030 8.62 CES2 CES1

Sources for Large Intestine Adenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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