Large Intestine Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Intestine Adenoma

MalaCards integrated aliases for Large Intestine Adenoma:

Name: Large Intestine Adenoma ¹¹ ¹⁴

Adenoma of Large Intestine ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050914

UMLS ⁷¹ C1302401

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Summaries for Large Intestine Adenoma

Disease Ontology: ¹¹ An intestinal benign neoplasm that has material basis in epithelial tissue with glandular origin and is located in the large intestine.

MalaCards based summary: Large Intestine Adenoma, also known as adenoma of large intestine, is related to anismus and alveolar echinococcosis. An important gene associated with Large Intestine Adenoma is GUCA2A (Guanylate Cyclase Activator 2A), and among its related pathways/superpathways are Breast cancer pathway and Neural crest differentiation. The drugs Levoleucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include large intestine, and related phenotype is hearing/vestibular/ear.

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Related Diseases for Large Intestine Adenoma

Diseases related to Large Intestine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	anismus	10.0	GUCY2C GUCA2A
2	alveolar echinococcosis	9.9	CES2 CES1
3	taeniasis	9.9	CES2 CES1
4	cystic echinococcosis	9.9	CES2 CES1
5	secretory diarrhea	9.9	GUCY2C GUCA2A
6	cysticercosis	9.9	CES2 CES1
7	parasitic helminthiasis infectious disease	9.7	CES2 CES1
8	alagille syndrome 1	9.5	HES5 DLL3

Graphical network of the top 20 diseases related to Large Intestine Adenoma:

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Symptoms & Phenotypes for Large Intestine Adenoma

MGI Mouse Phenotypes related to Large Intestine Adenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear	MP:0005377	8.92	APC CES1 DLL3 HES5

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Drugs & Therapeutics for Large Intestine Adenoma

Drugs for Large Intestine Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Levoleucovorin

Approved, Experimental, Investigational

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Synonyms:

(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate

(6R)-Leucovorin

(6R,2'S)-Folinic acid

(6R,S)-5-Formyltetrahydrofolate

(6S)-5-Formyl-5,6,7,8-tetrahydrofolate

(6S)-5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID

(6S)-5-Formyltetrahydrofolate

(6S)-5-FORMYLTETRAHYDROFOLIC ACID

(6S)-Folinate

(6S)-FOLINIC ACID

(6S)-LEUCOVORIN

(S)-LEUCOVORIN

[6R]-5-formyl-5,6,7,8-tetrahydrofolate

10-Formyl-7,8-dihydrofolate

10-Formyl-7,8-dihydrofolic acid

5 Formyltetrahydrofolate

5 Formyltetrahydropteroylglutamate

5-Formlyl-5,6,7,8-tetrahydrofolate,calcium salt

5-Formyl-(6S)-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydrofolate

5-Formyl-5,6,7,8-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid

5-Formyltetrahydrofolate

5-Formyltetrahydrofolic acid

5-Formyltetrahydropteroylglutamate

5-Formyltetrahydropteroylglutamic acid

5-formylTHF

6 S Leucovorin

6R-Leucovorin

6S Leucovorin

6S-Leucovorin

6-S-Leucovorin

Acid, folinic

Acide folinique

Acido folinico

ácido levofolínico

Calcium citrovorum factor

Calcium folinate

Calcium leucovorin

CF

Citrovorum factor

Dextrofolinic acid

Factor, citrovorum

Folinate

Folinate, calcium

Folinic acid

Folinic acid calcium salt

Folinic acid calcium salt USP27

Folinic acid SF

Folinic acid-SF

FUSILEV

KHAPZORY

Kunyrin

L(-)-5-Formyl-5,6,7,8-tetrahydrofolate

L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid

Leucal

Leucoverin

Leucovorin

Leucovorin calcium

Leucovorin folinic acid

Leucovorin, (D)-isomer

Leucovorin, (DL)-isomer

Leucovorin, (R)-isomer

Leucovorin, (S)-isomer

Leucovorin, calcium

Leucovorin, calcium (1:1) salt

Leucovorin, calcium (1:1) salt, (DL)-isomer

Leucovorin, calcium (1:1) salt, (S)-isomer

Leucovorin, calcium (1:1) salt, pentahydrate

Leucovorin, monopotassium salt, (S)-isomer

Leucovorin, monosodium salt

Leucovorin, monosodium salt, (S)-isomer

Leucovorinum

Leukovorin

Leukovorum

Levo leucovorin

LEVOFOLENE

Levofolinate

LEVOFOLINIC ACID

Levoleucovorin

Levo-leucovorin

L-Folinate

L-FOLINIC ACID

LFP-754

L-Leucovorin

L-N-[P-[[(2-amino-5-Formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid

Monosodium salt leucovorin

N(5)-Formyltetrahydrofolate

N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid

N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamate

N-[4-({[(6S)-2-AMINO-5-FORMYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID

N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid

N5-Formyl-5,6,7,8-tetrahydrofolate

N5-Formyl-5,6,7,8-tetrahydrofolic acid

N5-Formyltetrahydrofolate

N5-Formyltetrahydrofolic acid

N5-Formyl-THF

Pteroyl-D-glutamate

Rescuvolin

S Leucovorin

S-Leucovorin

Welcovorin

Wellcovorin

2

Folic acid

Approved, Nutraceutical, Vet_approved

59-30-3

6037

3

Vitamins

4

Folate

5

Vitamin B9

6

Trace Elements

7

Vitamin B Complex

8

Hematinics

9

Micronutrients

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Versus Only Withdrawal of Colonoscopy: a Randomized, Controlled Trial	Completed	NCT01925833
2	The Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) Folic Acid Prevention Trial	Completed	NCT00512850

Search NIH Clinical Center for Large Intestine Adenoma

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Genetic Tests for Large Intestine Adenoma

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Anatomical Context for Large Intestine Adenoma

Organs/tissues related to Large Intestine Adenoma:

FMA: Large Intestine

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Publications for Large Intestine Adenoma

Articles related to Large Intestine Adenoma:

#	Title	Authors	PMID	Year
1	Does human papilloma virus participate in colorectal carcinogenesis? ⁶²	Snietura M...Muc-Wierzgon M	23241125	2012
2	[Colonoscopy monitoring intervals after polypectomy of adenomas of the large intestine in patients younger than 40 years of age]. ⁶²	Batovsky M...Slugen I	7812850	1994

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Genes for Large Intestine Adenoma

Genes related to Large Intestine Adenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GUCA2A	Guanylate Cyclase Activator 2A	Protein Coding	5.36	DISEASES inferred ¹⁴
2	CES2	Carboxylesterase 2	Protein Coding	5.09	DISEASES inferred ¹⁴
3	GUCY2C	Guanylate Cyclase 2C	Protein Coding	4.96	DISEASES inferred ¹⁴
4	CES1	Carboxylesterase 1	Protein Coding	4.78	DISEASES inferred ¹⁴
5	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	4.76	DISEASES inferred ¹⁴
6	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	4.62	DISEASES inferred ¹⁴
7	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	4.56	DISEASES inferred ¹⁴

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Variations for Large Intestine Adenoma

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Expression for Large Intestine Adenoma

Search GEO for disease gene expression data for Large Intestine Adenoma.

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Pathways for Large Intestine Adenoma

Pathways related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	11.56	HES5 DLL3 APC
2	Neural crest differentiation ⁷⁴	11.41	HES5 DLL3
3	Overlap between signal transduction pathways contributing to LMNA laminopathies ⁷⁴ Show member pathways Influence of laminopathies on Wnt signaling ⁷⁴	11.34	HES5 APC
4	Digestion and absorption ⁶⁶ Show member pathways Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) ⁶⁶ Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) ⁶⁶ Digestion ⁶⁶ Digestion of dietary carbohydrate ⁶⁶ Digestion of dietary lipid ⁶⁶ Intestinal absorption ⁶⁶ Intestinal hexose absorption ⁶⁶ Intestinal lipid absorption ⁶⁶ Intestinal saccharidase deficiencies ⁶⁶	11.22	GUCY2C GUCA2A
5	Fluoropyrimidine activity ⁷⁴ Show member pathways Fluoropyrimidine Pathway, Pharmacodynamics ⁶⁰ Fluoropyrimidine Pathway, Pharmacokinetics ⁶⁰ superpathway of pyrimidine ribonucleosides degradation ⁶¹	11.12	CES2 CES1
6	Notch signaling (WikiPathways) ⁷⁴	10.81	HES5 DLL3
7	Phase I biotransformations, non P450 ⁷⁴ Show member pathways Heroin metabolism ⁷⁴ Methylphenidate Pathway, Pharmacokinetics ⁶⁰	9.66	CES2 CES1

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GO Terms for Large Intestine Adenoma

Biological processes related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cell differentiation	GO:0045595	8.92	HES5 APC

Molecular functions related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	carboxylic ester hydrolase activity	GO:0052689	9.46	CES2 CES1
2	methylumbelliferyl-acetate deacetylase activity	GO:0047374	9.26	CES2 CES1
3	methyl indole-3-acetate esterase activity	GO:0080030	8.62	CES2 CES1

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Sources for Large Intestine Adenoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRG015 MIFTS: 22	Large Intestine Adenoma Categories: Cancer diseases, Gastrointestinal diseases	Data Licensing For inquiries, contact: [email protected]
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