Large Intestine Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Large Intestine Adenoma

MalaCards integrated aliases for Large Intestine Adenoma:

Name: Large Intestine Adenoma ¹² ¹⁵

Adenoma of Large Intestine ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050914

UMLS ⁷¹ C1302401

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Summaries for Large Intestine Adenoma

Disease Ontology : ¹² An intestinal benign neoplasm that has material basis in epithelial tissue with glandular origin and is located in the large intestine.

MalaCards based summary : Large Intestine Adenoma, also known as adenoma of large intestine, is related to adenoma and polycystic echinococcosis. An important gene associated with Large Intestine Adenoma is GUCA2A (Guanylate Cyclase Activator 2A), and among its related pathways/superpathways are NRF2 pathway and Neural Crest Differentiation. The drugs leucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include large intestine.

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Related Diseases for Large Intestine Adenoma

Diseases related to Large Intestine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	adenoma	10.2
2	polycystic echinococcosis	9.8	CES2 CES1
3	cystic echinococcosis	9.8	CES2 CES1
4	echinococcosis	9.7	CES2 CES1
5	cataract 1, multiple types	9.7	CES2 CES1
6	taeniasis	9.7	CES2 CES1
7	alveolar echinococcosis	9.7	CES2 CES1
8	secretory diarrhea	9.6	GUCY2C GUCA2A
9	parasitic helminthiasis infectious disease	9.4	CES2 CES1
10	diarrhea	8.9	GUCY2C CES2 CES1

Graphical network of the top 20 diseases related to Large Intestine Adenoma:

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Symptoms & Phenotypes for Large Intestine Adenoma

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Drugs & Therapeutics for Large Intestine Adenoma

Drugs for Large Intestine Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

leucovorin

Approved

58-05-9

6006 143

Synonyms:

(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate

(6R,S)-5-Formyltetrahydrofolate

10-Formyl-7,8-dihydrofolate

10-Formyl-7,8-dihydrofolic acid

5 Formyltetrahydrofolate

5 Formyltetrahydropteroylglutamate

5-Formyl-5,6,7,8-tetrahydrofolate

5-Formyl-5,6,7,8-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid

5-formyltetrahydrofolate

5-Formyltetrahydrofolate

5-formyltetrahydrofolic acid

5-Formyltetrahydrofolic acid

5-Formyltetrahydropteroylglutamate

5-Formyltetrahydropteroylglutamic acid

5-formylTHF

Acid, folinic

Acide folinique

Acido folinico

Calcium citrovorum factor

Calcium folinate

Calcium leucovorin

Citrovorum factor

Factor, citrovorum

Folinate

Folinate, calcium

Folinic acid

Folinic acid calcium salt

Folinic acid calcium salt USP27

Folinic acid SF

Folinic acid-SF

L(-)-5-Formyl-5,6,7,8-tetrahydrofolate

L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid

Leucal

Leucovorin

Leucovorin calcium

Leucovorin folinic acid

Leucovorin, (D)-isomer

Leucovorin, (DL)-isomer

Leucovorin, (R)-isomer

Leucovorin, calcium

Leucovorin, calcium (1:1) salt

Leucovorin, calcium (1:1) salt, (DL)-isomer

Leucovorin, calcium (1:1) salt, pentahydrate

Leucovorin, monosodium salt

Leucovorinum

Leukovorin

Leukovorum

Levoleucovorin

L-leucovorin

L-Leucovorin

L-N-[P-[[(2-amino-5-Formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid

Monosodium salt leucovorin

N(5)-Formyltetrahydrofolate

N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid

N5-Formyl-5,6,7,8-tetrahydrofolate

N5-Formyl-5,6,7,8-tetrahydrofolic acid

N5-Formyltetrahydrofolate

N5-Formyltetrahydrofolic acid

Rescuvolin

Welcovorin

Wellcovorin

2

Folic acid

Approved, Nutraceutical, Vet_approved

59-30-3

6037

Synonyms:

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

01769_FLUKA

2d0k

33609-88-0

36653-55-1 (mono-potassium salt)

59-30-3

6484-89-5 (mono-hydrochloride salt)

AC-11682

AC1L1LNX

Acfol (Spain)

Acide folique

Acide folique [INN-French]

Acido folico

ácido fólico

Acido folico [INN-Spanish]

Acidum folicum

Acidum folicum [INN-Latin]

Acifolic

AI3-26387

AKOS000503224

Antianemia factor

Apo-Folic

ARONIS014410

b9, Vitamin

BIDD:ER0563

BIDD:GT0641

BIF0608

bmse000299

BPBio1_000654

BSPBio_000594

BSPBio_002338

C00504

C20H20N6O6

CAS-59-30-3

CCRIS 666

CHEBI:27470

CHEMBL1622

CID6037

CPD000471860

Cytofol

D00070

DB00158

DivK1c_000494

Dosfolat b activ

Dosfolat B activ

EINECS 200-419-0

F0043

F7876_SIAL

F7876_SIGMA

F8758_SIGMA

F8798_SIAL

F8890_SIGMA

Facid

Factor U

FOL

Folacid

Folacin

Folaemin

Folaemin [Netherlands]

Folan

Folasic (Australia)

Folate

Folbal

Folcidin

Folcidin (VAN)

Folcysteine

Foldine

Foldine [France]

Folettes

Foliamin

Folic

folic acid

Folic acid

Folic acid (JP15/USP/INN)

Folic acid (TN)

Folic acid [BAN:INN:JAN]

Folic acid [INN:BAN:JAN]

Folic acid dihydrate

Folic acid, (D)-isomer

Folic acid, (DL)-isomer

Folic acid, calcium salt (1:1)

Folic acid, monopotassium salt

Folic acid, monosodium salt

Folic acid, potassium salt

Folic acid, sodium salt

Folicet

Folicet (TN)

Folico

Folico (Italy)

Folina

Folina (Italy)

Folipac

Folsaeure

Folsan

Folsaure

Folsäure

Folsav

Folvite

Folvron

Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L

HMS1921D20

HMS2092N17

HMS501I16

HSDB 2002

IDI1_000494

Incafolic

InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s

KBio1_000494

KBio2_001861

KBio2_004429

KBio2_006997

KBio3_001558

KBioGR_002222

KBioSS_001861

Kyselina listova

Kyselina listova [Czech]

Liver lactobacillus casei factor

Liver Lactobacillus casei factor

LS-2157

Millafol

Mission prenatal

Mittafol

MLS001304016

MLS001335861

MolPort-004-285-551

N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid

N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid

N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-Pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

NCGC00016265-01

NCGC00142391-01

nchembio.108-comp10

Nifolin

Nifolin [Denmark]

NINDS_000494

Novofolacid

Novofolacid [Canada]

N-Pteroyl-L-glutamate

N-pteroyl-L-glutamic acid

N-Pteroyl-L-glutamic acid

NSC 3073

PGA

PGA (VAN)

Prestwick_230

Prestwick3_000627

PteGlu

Pteroylglutamate

Pteroylglutamic acid

Pteroyl-L-glutamate

Pteroyl-L-glutamic acid

Pteroyl-L-monoglutamate

Pteroyl-L-monoglutamic acid

Pteroylmonoglutamate

Pteroylmonoglutamic acid

SAM002264616

SDCCGMLS-0066738.P001

Serum Folate Level

SMP2_000137

SMR000471860

SPBio_001357

Spectrum_001381

SPECTRUM1502020

Spectrum2_001459

Spectrum3_000749

Spectrum4_001751

Spectrum5_000602

UNII-935E97BOY8

Usaf cb-13

Vitamin B11

Vitamin b9

Vitamin B9

Vitamin Bc

Vitamin BC

Vitamin be

Vitamin Be

Vitamin m

Vitamin M

3

Micronutrients

4

Trace Elements

5

Vitamins

6

Vitamin B Complex

7

Hematinics

8

Nutrients

9

Folate

10

Vitamin B9

Interventional clinical trials:

#	Name	Status	NCT ID
1	Comparison of Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Versus Only Withdrawal of Colonoscopy: a Randomized, Controlled Trial	Completed	NCT01925833
2	The Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) Folic Acid Prevention Trial	Completed	NCT00512850
3	Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine	Completed	NCT03551379

Search NIH Clinical Center for Large Intestine Adenoma

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Genetic Tests for Large Intestine Adenoma

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Anatomical Context for Large Intestine Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Large Intestine Adenoma:

¹⁹

Large Intestine

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Publications for Large Intestine Adenoma

Articles related to Large Intestine Adenoma:

#	Title	Authors	PMID	Year
1	Does human papilloma virus participate in colorectal carcinogenesis? ⁶¹	Snietura M...Muc-Wierzgon M	23241125	2012
2	[Serrated adenoma of large intestine: report of 7 cases]. ⁶¹	Liu SD...Wan TM	12390795	2002
3	[A clinicopathological study of 3 dimensional structure in adenoma of large intestine]. ⁶¹	Zhang Y...Takahashi T	8732093	1995
4	[Colonoscopy monitoring intervals after polypectomy of adenomas of the large intestine in patients younger than 40 years of age]. ⁶¹	Batovsky M...Slugen I	7812850	1994

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Genes for Large Intestine Adenoma

Genes related to Large Intestine Adenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GUCA2A	Guanylate Cyclase Activator 2A	Protein Coding	5.78	DISEASES inferred ¹⁵
2	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	5.27	DISEASES inferred ¹⁵
3	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	5.24	DISEASES inferred ¹⁵
4	CES2	Carboxylesterase 2	Protein Coding	5.21	DISEASES inferred ¹⁵
5	GUCY2C	Guanylate Cyclase 2C	Protein Coding	5.14	DISEASES inferred ¹⁵
6	CES1	Carboxylesterase 1	Protein Coding	5.11	DISEASES inferred ¹⁵

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Variations for Large Intestine Adenoma

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Expression for Large Intestine Adenoma

Search GEO for disease gene expression data for Large Intestine Adenoma.

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Pathways for Large Intestine Adenoma

Pathways related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NRF2 pathway ¹	11.59	CES2 CES1
2	Neural Crest Differentiation ¹	11.41	HES5 DLL3
3	Fluoropyrimidine Activity ¹ Show member pathways Fluoropyrimidine Pathway, Pharmacodynamics ⁶⁰ Fluoropyrimidine Pathway, Pharmacokinetics ⁶⁰ glutamate removal from folates ¹ pyrimidine ribonucleosides degradation ¹	11.24	CES2 CES1
4	E2F transcription factor network ¹	11.18	CES2 CES1
5	Irinotecan Pathway, Pharmacokinetics ⁶⁰ Show member pathways Irinotecan Pathway ¹ Irinotecan Pathway, Pharmacodynamics ⁶⁰ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.03	CES2 CES1
6	the visual cycle I (vertebrates) ¹ Show member pathways retinol biosynthesis ¹ The canonical retinoid cycle in rods (twilight vision) ⁶⁵	10.9	CES2 CES1
7	Phase I biotransformations, non P450 ¹	9.86	CES2 CES1
8	Miscellaneous digestion events ⁶⁵	9.23	GUCY2C GUCA2A

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GO Terms for Large Intestine Adenoma

Biological processes related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid catabolic process	GO:0016042	9.32	CES2 CES1
2	Notch signaling pathway	GO:0007219	9.26	HES5 DLL3
3	response to toxic substance	GO:0009636	9.16	GUCY2C CES1
4	xenobiotic metabolic process	GO:0006805	8.96	CES2 CES1
5	digestion	GO:0007586	8.62	GUCY2C GUCA2A

Molecular functions related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	carboxylic ester hydrolase activity	GO:0052689	9.32	CES2 CES1
2	triglyceride lipase activity	GO:0004806	9.26	CES2 CES1
3	sterol esterase activity	GO:0004771	9.16	CES2 CES1
4	methyl indole-3-acetate esterase activity	GO:0080030	8.96	CES2 CES1
5	methylumbelliferyl-acetate deacetylase activity	GO:0047374	8.62	CES2 CES1

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Sources for Large Intestine Adenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia