MCID: LRG015
MIFTS: 24

Large Intestine Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Large Intestine Adenoma

MalaCards integrated aliases for Large Intestine Adenoma:

Name: Large Intestine Adenoma 12 15
Adenoma of Large Intestine 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050914
UMLS 71 C1302401

Summaries for Large Intestine Adenoma

Disease Ontology : 12 An intestinal benign neoplasm that has material basis in epithelial tissue with glandular origin and is located in the large intestine.

MalaCards based summary : Large Intestine Adenoma, also known as adenoma of large intestine, is related to adenoma and anismus. An important gene associated with Large Intestine Adenoma is GUCA2A (Guanylate Cyclase Activator 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs leucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include large intestine.

Related Diseases for Large Intestine Adenoma

Diseases related to Large Intestine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 adenoma 10.2
2 anismus 9.9 GUCY2C GUCA2A
3 large intestine cancer 9.8
4 secretory diarrhea 9.7 GUCY2C GUCA2A
5 cataract 1, multiple types 9.6 CES2 CES1
6 polycystic echinococcosis 9.6 CES2 CES1
7 cystic echinococcosis 9.6 CES2 CES1
8 echinococcosis 9.6 CES2 CES1
9 taeniasis 9.5 CES2 CES1
10 alveolar echinococcosis 9.5 CES2 CES1
11 parasitic helminthiasis infectious disease 9.2 CES2 CES1

Graphical network of the top 20 diseases related to Large Intestine Adenoma:



Diseases related to Large Intestine Adenoma

Symptoms & Phenotypes for Large Intestine Adenoma

Drugs & Therapeutics for Large Intestine Adenoma

Drugs for Large Intestine Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved 58-05-9 6006 143
2
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
3 Micronutrients
4 Vitamins
5 Trace Elements
6 Hematinics
7 Vitamin B Complex
8 Vitamin B9
9 Nutrients
10 Folate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Versus Only Withdrawal of Colonoscopy: a Randomized, Controlled Trial Completed NCT01925833
2 The Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) Folic Acid Prevention Trial Completed NCT00512850
3 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379

Search NIH Clinical Center for Large Intestine Adenoma

Genetic Tests for Large Intestine Adenoma

Anatomical Context for Large Intestine Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Large Intestine Adenoma:

19
Large Intestine

Publications for Large Intestine Adenoma

Articles related to Large Intestine Adenoma:

# Title Authors PMID Year
1
Does human papilloma virus participate in colorectal carcinogenesis? 61
23241125 2012
2
[Serrated adenoma of large intestine: report of 7 cases]. 61
12390795 2002
3
[A clinicopathological study of 3 dimensional structure in adenoma of large intestine]. 61
8732093 1995
4
[Colonoscopy monitoring intervals after polypectomy of adenomas of the large intestine in patients younger than 40 years of age]. 61
7812850 1994

Variations for Large Intestine Adenoma

Expression for Large Intestine Adenoma

Search GEO for disease gene expression data for Large Intestine Adenoma.

Pathways for Large Intestine Adenoma

GO Terms for Large Intestine Adenoma

Biological processes related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex assembly GO:0065003 9.37 HES5 APC
2 Notch signaling pathway GO:0007219 9.32 HES5 DLL3
3 response to toxic substance GO:0009636 9.26 GUCY2C CES1
4 xenobiotic metabolic process GO:0006805 9.16 CES2 CES1
5 regulation of cell differentiation GO:0045595 8.96 HES5 APC
6 digestion GO:0007586 8.62 GUCY2C GUCA2A

Molecular functions related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic ester hydrolase activity GO:0052689 9.16 CES2 CES1
2 methyl indole-3-acetate esterase activity GO:0080030 8.96 CES2 CES1
3 methylumbelliferyl-acetate deacetylase activity GO:0047374 8.62 CES2 CES1

Sources for Large Intestine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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