MCID: LRG015
MIFTS: 26

Large Intestine Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Large Intestine Adenoma

MalaCards integrated aliases for Large Intestine Adenoma:

Name: Large Intestine Adenoma 12 15
Adenoma of Large Intestine 72

Classifications:



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Disease Ontology 12 DOID:0050914
UMLS 72 C1302401

Summaries for Large Intestine Adenoma

Disease Ontology : 12 An intestinal benign neoplasm that has material basis in epithelial tissue with glandular origin and is located in the large intestine.

MalaCards based summary : Large Intestine Adenoma, also known as adenoma of large intestine, is related to adenoma and cystic echinococcosis. An important gene associated with Large Intestine Adenoma is CES2 (Carboxylesterase 2), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs leucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include large intestine.

Related Diseases for Large Intestine Adenoma

Graphical network of the top 20 diseases related to Large Intestine Adenoma:



Diseases related to Large Intestine Adenoma

Symptoms & Phenotypes for Large Intestine Adenoma

Drugs & Therapeutics for Large Intestine Adenoma

Drugs for Large Intestine Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved 58-05-9 143 6006
2
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
3 Micronutrients
4 Hematinics
5 Trace Elements
6 Vitamins
7 Folate
8 Vitamin B9
9 Vitamin B Complex
10 Nutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Versus Only Withdrawal of Colonoscopy: a Randomized, Controlled Trial Completed NCT01925833
2 The Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) Folic Acid Prevention Trial Completed NCT00512850
3 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379

Search NIH Clinical Center for Large Intestine Adenoma

Genetic Tests for Large Intestine Adenoma

Anatomical Context for Large Intestine Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Large Intestine Adenoma:

19
Large Intestine

Publications for Large Intestine Adenoma

Articles related to Large Intestine Adenoma:

# Title Authors PMID Year
1
Does human papilloma virus participate in colorectal carcinogenesis? 38
23241125 2012
2
[Serrated adenoma of large intestine: report of 7 cases]. 38
12390795 2002
3
[A clinicopathological study of 3 dimensional structure in adenoma of large intestine]. 38
8732093 1995
4
[Colonoscopy monitoring intervals after polypectomy of adenomas of the large intestine in patients younger than 40 years of age]. 38
7812850 1994

Variations for Large Intestine Adenoma

Expression for Large Intestine Adenoma

Search GEO for disease gene expression data for Large Intestine Adenoma.

Pathways for Large Intestine Adenoma

Pathways related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 UGT1A8 UGT1A6 UGT1A1 GUSB CES2 CES1
2
Show member pathways
12.77 UGT1A8 UGT1A6 UGT1A1 CES2 CES1
3 12.16 UGT1A8 UGT1A6 UGT1A1
4
Show member pathways
11.91 UGT1A8 UGT1A6 UGT1A1 GUSB
5
Show member pathways
11.83 UGT1A8 UGT1A6 UGT1A1 GUSB CES2 CES1
6
Show member pathways
11.48 UGT1A8 UGT1A6 UGT1A1
7 11.42 UGT1A6 UGT1A1 CES2 CES1
8 11.41 CES2 CES1
9
Show member pathways
11.34 UGT1A6 UGT1A1
10
Show member pathways
11.32 UGT1A8 UGT1A6 UGT1A1
11
Show member pathways
11.26 CES2 CES1
12 11.19 UGT1A6 UGT1A1
13 10.98 UGT1A6 UGT1A1
14
Show member pathways
10.86 UGT1A8 UGT1A6 UGT1A1
15 10.34 CES2 CES1

GO Terms for Large Intestine Adenoma

Cellular components related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.26 UGT1A8 UGT1A6 UGT1A1 GUSB
2 endoplasmic reticulum GO:0005783 9.02 UGT1A8 UGT1A6 UGT1A1 CES2 CES1

Biological processes related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.5 UGT1A6 CES2 CES1
2 steroid metabolic process GO:0008202 9.46 UGT1A8 UGT1A1
3 negative regulation of catalytic activity GO:0043086 9.43 UGT1A8 UGT1A1
4 retinoic acid metabolic process GO:0042573 9.4 UGT1A8 UGT1A1
5 cellular glucuronidation GO:0052695 9.37 UGT1A6 UGT1A1
6 flavone metabolic process GO:0051552 9.26 UGT1A8 UGT1A1
7 negative regulation of steroid metabolic process GO:0045939 9.16 UGT1A8 UGT1A1
8 xenobiotic glucuronidation GO:0052697 9.13 UGT1A8 UGT1A6 UGT1A1
9 flavonoid glucuronidation GO:0052696 8.8 UGT1A8 UGT1A6 UGT1A1

Molecular functions related to Large Intestine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.65 UGT1A8 UGT1A6 UGT1A1
2 transferase activity, transferring glycosyl groups GO:0016757 9.54 UGT1A8 UGT1A6 UGT1A1
3 carboxylic ester hydrolase activity GO:0052689 9.46 CES2 CES1
4 enzyme inhibitor activity GO:0004857 9.43 UGT1A8 UGT1A1
5 transferase activity, transferring hexosyl groups GO:0016758 9.43 UGT1A8 UGT1A6 UGT1A1
6 steroid binding GO:0005496 9.4 UGT1A8 UGT1A1
7 glucuronosyltransferase activity GO:0015020 9.33 UGT1A8 UGT1A6 UGT1A1
8 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.32 CES2 CES1
9 retinoic acid binding GO:0001972 9.13 UGT1A8 UGT1A6 UGT1A1
10 UDP-glycosyltransferase activity GO:0008194 8.8 UGT1A8 UGT1A6 UGT1A1

Sources for Large Intestine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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