MCID: LRG017
MIFTS: 33

Large Intestine Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases
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Aliases & Classifications for Large Intestine Cancer

MalaCards integrated aliases for Large Intestine Cancer:

Name: Large Intestine Cancer 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:5672
NCIt 49 C4978
SNOMED-CT 68 93854002
ICD10 31 C18.9
UMLS 71 C0346629

Summaries for Large Intestine Cancer

Disease Ontology: 11 An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.

MalaCards based summary: Large Intestine Cancer is related to colorectal cancer and colonic benign neoplasm. An important gene associated with Large Intestine Cancer is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. Affiliated tissues include colon, small intestine and spleen.

Related Diseases for Large Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ
Rare Carcinoma of Small Intestine

Diseases related to Large Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 32.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
2 colonic benign neoplasm 31.0 MIR21 MIR199A1 MIR18A MIR145 MIR143 H2AC18
3 gastric cancer 30.8 MIR34A MIR30A MIR21 MIR199A1 MIR196A1 MIR17
4 anal canal carcinoma 11.1
5 large intestine adenocarcinoma 11.1
6 anus cancer 11.1
7 cecum carcinoma 11.1
8 nervous system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
9 bladder disease 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
10 lung cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
11 reproductive system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
12 gastrointestinal system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
13 stomach disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
14 lymphatic system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
15 connective tissue disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
16 intestinal disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
17 thoracic cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
18 male reproductive organ cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
19 breast disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
20 central nervous system cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
21 gastrointestinal system cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
22 endocrine system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
23 immune system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
24 pancreas disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
25 hematologic cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
26 cervix disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
27 female reproductive system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
28 connective tissue cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
29 urinary system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
30 respiratory system disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
31 colonic disease 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
32 endocrine gland cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
33 male reproductive system disease 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
34 lymphatic system cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
35 malignant exocrine pancreas neoplasm 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
36 spinal disease 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
37 lymphoma, non-hodgkin, familial 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
38 respiratory system cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
39 uterine anomalies 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
40 hepatocellular carcinoma 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
41 malignant astrocytoma 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
42 cell type benign neoplasm 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
43 biliary tract disease 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
44 oral cavity cancer 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
45 pancreatic ductal adenocarcinoma 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
46 bile duct adenocarcinoma 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
47 head and neck cancer 10.7 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
48 bone cancer 10.7 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
49 lung cancer susceptibility 3 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
50 biliary tract cancer 10.7 MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A

Graphical network of the top 20 diseases related to Large Intestine Cancer:



Diseases related to Large Intestine Cancer

Symptoms & Phenotypes for Large Intestine Cancer

Drugs & Therapeutics for Large Intestine Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes Recruiting NCT04907643 Phase 2
2 GI 1549: PROGRAMS TO SUPPORT YOU DURING CHEMOTHERAPY (PRO-YOU) A Randomized Controlled Pilot Study of Yoga Compared to an Attention Control in Patients Receiving Chemotherapy Completed NCT02489422

Search NIH Clinical Center for Large Intestine Cancer

Genetic Tests for Large Intestine Cancer

Anatomical Context for Large Intestine Cancer

Organs/tissues related to Large Intestine Cancer:

MalaCards : Colon, Small Intestine, Spleen, Lung

Publications for Large Intestine Cancer

Articles related to Large Intestine Cancer:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Subsequent Primary Cancers of the Digestive System Among Childhood and Adolescent Cancer Survivors From 1975 to 2015 in the United States. 62
33929381 2021
2
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. 62
33202274 2021
3
LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3β/β-catenin pathway. 62
32749739 2020
4
Cohort study of occupational cosmic radiation dose and cancer mortality in German aircrew, 1960-2014. 62
32075886 2020
5
Neoplastic sigmoid-uterine fistula. An exceptional complication of large intestine cancer. 62
28460202 2017
6
Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. 62
27642112 2016
7
Concentrations of cadmium and selected essential elements in malignant large intestine tissue. 62
27110307 2016
8
[Efficacy evaluation of heat-sensitive moxibustion for chemotherapy symptoms of large intestine cancer]. 62
26790207 2015
9
[The possibilities of laparoscopic technology in surgical treatment of large intestine cancer]. 62
24640763 2013
10
Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. 62
23612677 2013
11
Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location. 62
23788900 2012
12
[Optimal methods of rehabilitation of patients after a left-side colostomy]. 62
19801720 2009
13
[Quantified diagnositic standard for large intestinal cancer of spleen qi deficiency syndrome.]. 62
19747434 2009
14
[Coronary artery disease attack caused by cytotoxic chemotherapy]. 62
19517869 2009
15
Test for obscure bleeding vs colonoscopy in the prevention of colorectal cancer. 62
18822943 2008
16
[Restorative surgery in large intestine cancer]. 62
18410013 2007
17
[Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy]. 62
16620711 2006
18
The diversity expression of p62 in digestive system cancers. 62
15886058 2005
19
Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. 62
15655830 2005
20
In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy. 62
15637737 2005
21
[Effect of palliative chemotherapy with topoisomerase inhibitor on the quality of life and survival of patients with advanced colorectal carcinoma]. 62
15754631 2004
22
[Mortality rate in reconstructive plastic surgery in patients with cardiorespiratory diseases]. 62
15318828 2004
23
Antioxidative activity of animal and vegetable dietary fibers. 62
15630221 2004
24
[Correlation between family and age of manifestation of lung and colon cancer]. 62
14964840 2003
25
Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases. 62
12679948 2003
26
[Variations of cellular membrane phospholipids with genesis and hepatic metastasis of large intestine cancer]. 62
12417063 2002
27
[The role of Fas/Fas ligand in tumorgenesis, immune escape, and counterattack in colonic cancer]. 62
12137598 2002
28
[Preparation and in vitro killing effect of adriamycin-loaded immunonanosphere against hepatoma led by F (ab')2 Fragment of monoclonal antibodies]. 62
12599415 2002
29
[Efficacy of lidocaine cream in protecting against thermal stress during hyperthermia]. 62
11201383 2001
30
[Effect of chang'ai kangfu decoction on immunity in postoperational patients with large intestine cancer]. 62
11789186 2000
31
[N-acetyltransferase genetic polymorphism and its role in the development of neoplastic disease]. 62
11002474 2000
32
Mortality of workers at two asbestos-cement plants in Poland. 62
10967842 2000
33
[Does fecal occult blood screening result in decreased mortality from large intestine cancer?]. 62
9340935 1997
34
Cohort study on cancer mortality among workers in the pulp and paper industry in Catalonia, Spain. 62
8837689 1996
35
Proportionate mortality study of golf course superintendents. 62
8732923 1996
36
[Mortality among workers of the rubber industry. III. Results of further observation of the male cohort]. 62
7476145 1995
37
[Epidemiological data on precancerous conditions and neoplasms among workers in the petroleum-refining industry]. 62
2139624 1990
38
[Geographical correlation analysis between schistosomiasis and large intestine cancer]. 62
3147814 1988
39
[Early clinical diagnosis of stomach and large intestine cancer]. 62
3617781 1987
40
[Surgery of stomach and large intestine cancer in the elderly]. 62
2437711 1987
41
[Quadruple metachronous large intestine cancer]. 62
4013539 1985
42
[Plasma retinol, beta-carotene and ascorbic acid levels and functional activity of lymphocytes in patients with large intestine cancer]. 62
6332421 1984
43
[Our experience with emergency surgery in cancer of the large intestine]. 62
6680883 1983
44
Surgery in 932 cases of large intestine cancer. 62
6414771 1983
45
[Possibilities of surgical treatment of large intestine cancer in patients over 70]. 62
6857961 1983
46
Mortality among rubber workers: V. processing workers. 62
7119914 1982
47
[Parenteral feeding in the prevention and treatment of postoperative complications in stomach and large intestine cancer]. 62
6767322 1980
48
Variations in serum copper and ceruloplasmin levels in advanced gastrointestinal cancer treated with polychemotherapy. 62
462583 1979
49
[Possibilities of early diagnosis of large intestine cancer]. 62
1021900 1976
50
Symptoms of large-intestine cancer. 62
4176883 1968

Variations for Large Intestine Cancer

Expression for Large Intestine Cancer

Search GEO for disease gene expression data for Large Intestine Cancer.

Pathways for Large Intestine Cancer

Pathways related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 MIR199A1 MIR17 MIR145 MIR143
2 11.18 MIR21 MIR18A MIR17 MIR145 MIR143
3 10.81 MIR21 MIR199A1 MIR149 MIR145 MIR126

GO Terms for Large Intestine Cancer

Cellular components related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 MIR31 MIR30A MIR21 MIR199A1 MIR18A MIR17
2 RISC complex GO:0016442 9.75 MIR125A MIR126 MIR139 MIR142 MIR143 MIR145
3 extracellular vesicle GO:1903561 9.5 MIR34A MIR30A MIR21 MIR193A MIR17 MIR126

Biological processes related to Large Intestine Cancer according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 10.03 MIR34A MIR21 MIR199A1 MIR17 MIR125A
2 positive regulation of protein kinase B signaling GO:0051897 9.89 MIR21 MIR199A1 MIR143 MIR126
3 negative regulation of cell migration GO:0030336 9.88 MIR126 MIR145 MIR149 MIR21 MIR31 MIR34A
4 positive regulation of angiogenesis GO:0045766 9.85 MIR31 MIR30A MIR21 MIR199A1 MIR143 MIR126
5 miRNA-mediated gene silencing GO:0035195 9.8 MIR125A MIR126 MIR139 MIR142 MIR143 MIR145
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.76 MIR31 MIR30A MIR143 MIR126
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.75 MIR21 MIR199A1 MIR145
8 positive regulation of sprouting angiogenesis GO:1903672 9.73 MIR31 MIR126 MIR125A
9 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.73 MIR199A1 MIR196A1 MIR193A MIR149
10 negative regulation of inflammatory response GO:0050728 9.73 MIR31 MIR199A1 MIR149 MIR145 MIR142 MIR126
11 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.72 MIR31 MIR21 MIR17 MIR145 MIR126
12 negative regulation of sprouting angiogenesis GO:1903671 9.7 MIR34A MIR18A MIR17
13 negative regulation of vascular endothelial cell proliferation GO:1905563 9.69 MIR34A MIR193A MIR126
14 angiotensin-activated signaling pathway GO:0038166 9.64 MIR145 MIR143
15 positive regulation of connective tissue replacement GO:1905205 9.63 MIR34A MIR199A1
16 negative regulation of angiogenesis GO:0016525 9.63 MIR125A MIR143 MIR145 MIR193A MIR21 MIR34A
17 negative regulation of receptor signaling pathway via STAT GO:1904893 9.62 MIR149 MIR125A
18 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR199A1 MIR17
19 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
20 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 MIR145 MIR143
21 positive regulation of metalloendopeptidase activity GO:1904685 9.6 MIR21 MIR17
22 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.58 MIR31 MIR125A
23 regulation of phenotypic switching GO:1900239 9.57 MIR143 MIR145
24 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.55 MIR17 MIR143
25 positive regulation of cellular response to hypoxia GO:1900039 9.54 MIR21 MIR145
26 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.49 MIR145 MIR143
27 negative regulation of interleukin-16 production GO:0032699 9.48 MIR145 MIR125A
28 negative regulation of vascular endothelial growth factor production GO:1904046 9.26 MIR34A MIR199A1 MIR17 MIR125A

Molecular functions related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.77 MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR193A
2 mRNA base-pairing translational repressor activity GO:1903231 9.55 MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1

Sources for Large Intestine Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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