MCID: LRG017
MIFTS: 31

Large Intestine Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Large Intestine Cancer

MalaCards integrated aliases for Large Intestine Cancer:

Name: Large Intestine Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5672
NCIt 50 C4978
SNOMED-CT 67 93854002
ICD10 32 C18.9
UMLS 70 C0346629

Summaries for Large Intestine Cancer

Disease Ontology : 12 An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.

MalaCards based summary : Large Intestine Cancer is related to colorectal cancer and large intestine adenocarcinoma. An important gene associated with Large Intestine Cancer is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. Affiliated tissues include colon, small intestine and spleen.

Related Diseases for Large Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ
Rare Carcinoma of Small Intestine

Diseases related to Large Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 32.5 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
2 large intestine adenocarcinoma 11.1
3 anus cancer 11.1
4 intestinal benign neoplasm 10.7 MIR21 MIR199A1 MIR196A1 MIR18A MIR17 MIR145
5 gastrointestinal system benign neoplasm 10.7 MIR21 MIR199A1 MIR196A1 MIR18A MIR17 MIR143
6 tongue disease 10.7 MIR31 MIR21 MIR199A1 MIR196A1 MIR193A MIR18A
7 bile duct adenocarcinoma 10.7 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
8 autoimmune disease of musculoskeletal system 10.7 MIR34A MIR21 MIR199A1 MIR196A1 MIR17 MIR126
9 bile duct disease 10.7 MIR9-1 MIR199A1 MIR196A1 MIR17 MIR145 MIR139
10 bone inflammation disease 10.7 MIR34A MIR21 MIR199A1 MIR196A1 MIR17 MIR149
11 oral cavity cancer 10.7 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR193A
12 integumentary system disease 10.7 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
13 nasopharyngeal disease 10.7 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR193A
14 rectum cancer 10.7 MIR31 MIR21 MIR200A MIR193A MIR17 MIR145
15 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR17 MIR139
16 autosomal genetic disease 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR193A MIR17
17 sensory system disease 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR193A MIR17
18 hematologic cancer 10.7 MIR9-1 MIR518A1 MIR34A MIR31 MIR21 MIR199A1
19 central nervous system disease 10.7 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR18A
20 uterine anomalies 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
21 lymphatic system cancer 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR196A1
22 inherited metabolic disorder 10.7 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR17
23 bone marrow cancer 10.7 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR17
24 bone cancer 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR193A MIR17
25 gallbladder disease 10.7 MIR199A1 MIR196A1 MIR17 MIR145 MIR143 MIR126
26 laryngeal disease 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR196A1 MIR17
27 oral squamous cell carcinoma 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR196A1
28 squamous cell carcinoma, head and neck 10.7 MIR9-1 MIR31 MIR21 MIR200A MIR199A1 MIR196A1
29 arteries, anomalies of 10.7 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR17
30 overnutrition 10.7 MIR34A MIR21 MIR199A1 MIR196A1 MIR17 MIR126
31 cardiovascular system disease 10.7 MIR9-1 MIR34A MIR21 MIR199A1 MIR17 MIR145
32 leukocyte disease 10.7 MIR21 MIR199A1 MIR196A1 MIR17 MIR126 MIR125A
33 spinal disease 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR193A MIR17
34 bile duct cancer 10.7 MIR9-1 MIR31 MIR21 MIR199A1 MIR17 MIR145
35 bladder disease 10.7 MIR31 MIR21 MIR200A MIR199A1 MIR196A1 MIR193A
36 cervix disease 10.7 MIR9-1 MIR518A1 MIR34A MIR31 MIR21 MIR200A
37 leukemia, chronic lymphocytic 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR196A1
38 nervous system cancer 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
39 respiratory system cancer 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
40 renal cell carcinoma, nonpapillary 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
41 ovary epithelial cancer 10.7 MIR9-1 MIR21 MIR200A MIR199A1 MIR196A1 MIR193A
42 malignant ovarian surface epithelial-stromal neoplasm 10.7 MIR9-1 MIR21 MIR200A MIR199A1 MIR196A1 MIR193A
43 male reproductive system disease 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR196A1
44 nervous system disease 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
45 acquired metabolic disease 10.7 MIR9-1 MIR34A MIR21 MIR200A MIR199A1 MIR196A1
46 pancreatic ductal adenocarcinoma 10.7 MIR31 MIR21 MIR199A1 MIR196A1 MIR18A MIR145
47 colonic disease 10.7 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
48 thoracic cancer 10.6 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
49 chromosomal disease 10.6 MIR9-1 MIR31 MIR21 MIR196A1 MIR17 MIR126
50 immune system disease 10.6 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1

Graphical network of the top 20 diseases related to Large Intestine Cancer:



Diseases related to Large Intestine Cancer

Symptoms & Phenotypes for Large Intestine Cancer

Drugs & Therapeutics for Large Intestine Cancer

Search Clinical Trials , NIH Clinical Center for Large Intestine Cancer

Genetic Tests for Large Intestine Cancer

Anatomical Context for Large Intestine Cancer

MalaCards organs/tissues related to Large Intestine Cancer:

40
Colon, Small Intestine, Spleen

Publications for Large Intestine Cancer

Articles related to Large Intestine Cancer:

(show all 50)
# Title Authors PMID Year
1
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. 61
33202274 2021
2
LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3β/β-catenin pathway. 61
32749739 2020
3
Cohort study of occupational cosmic radiation dose and cancer mortality in German aircrew, 1960-2014. 61
32075886 2020
4
Neoplastic sigmoid-uterine fistula. An exceptional complication of large intestine cancer. 61
28460202 2017
5
Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. 61
27642112 2016
6
Concentrations of cadmium and selected essential elements in malignant large intestine tissue. 61
27110307 2016
7
[Efficacy evaluation of heat-sensitive moxibustion for chemotherapy symptoms of large intestine cancer]. 61
26790207 2015
8
[The possibilities of laparoscopic technology in surgical treatment of large intestine cancer]. 61
24640763 2013
9
Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. 61
23612677 2013
10
Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location. 61
23788900 2012
11
[Optimal methods of rehabilitation of patients after a left-side colostomy]. 61
19801720 2009
12
[Quantified diagnositic standard for large intestinal cancer of spleen qi deficiency syndrome.]. 61
19747434 2009
13
[Coronary artery disease attack caused by cytotoxic chemotherapy]. 61
19517869 2009
14
Test for obscure bleeding vs colonoscopy in the prevention of colorectal cancer. 61
18822943 2008
15
[Restorative surgery in large intestine cancer]. 61
18410013 2007
16
[Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy]. 61
16620711 2006
17
The diversity expression of p62 in digestive system cancers. 61
15886058 2005
18
Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. 61
15655830 2005
19
In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy. 61
15637737 2005
20
[Effect of palliative chemotherapy with topoisomerase inhibitor on the quality of life and survival of patients with advanced colorectal carcinoma]. 61
15754631 2004
21
[Mortality rate in reconstructive plastic surgery in patients with cardiorespiratory diseases]. 61
15318828 2004
22
Antioxidative activity of animal and vegetable dietary fibers. 61
15630221 2004
23
[Correlation between family and age of manifestation of lung and colon cancer]. 61
14964840 2003
24
Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases. 61
12679948 2003
25
[Variations of cellular membrane phospholipids with genesis and hepatic metastasis of large intestine cancer]. 61
12417063 2002
26
[The role of Fas/Fas ligand in tumorgenesis, immune escape, and counterattack in colonic cancer]. 61
12137598 2002
27
[Preparation and in vitro killing effect of adriamycin-loaded immunonanosphere against hepatoma led by F (ab')2 Fragment of monoclonal antibodies]. 61
12599415 2002
28
[Efficacy of lidocaine cream in protecting against thermal stress during hyperthermia]. 61
11201383 2001
29
[Effect of chang'ai kangfu decoction on immunity in postoperational patients with large intestine cancer]. 61
11789186 2000
30
Mortality of workers at two asbestos-cement plants in Poland. 61
10967842 2000
31
[N-acetyltransferase genetic polymorphism and its role in the development of neoplastic disease]. 61
11002474 2000
32
[Does fecal occult blood screening result in decreased mortality from large intestine cancer?]. 61
9340935 1997
33
Cohort study on cancer mortality among workers in the pulp and paper industry in Catalonia, Spain. 61
8837689 1996
34
Proportionate mortality study of golf course superintendents. 61
8732923 1996
35
[Mortality among workers of the rubber industry. III. Results of further observation of the male cohort]. 61
7476145 1995
36
[Epidemiological data on precancerous conditions and neoplasms among workers in the petroleum-refining industry]. 61
2139624 1990
37
[Geographical correlation analysis between schistosomiasis and large intestine cancer]. 61
3147814 1988
38
[Early clinical diagnosis of stomach and large intestine cancer]. 61
3617781 1987
39
[Surgery of stomach and large intestine cancer in the elderly]. 61
2437711 1987
40
[Quadruple metachronous large intestine cancer]. 61
4013539 1985
41
[Plasma retinol, beta-carotene and ascorbic acid levels and functional activity of lymphocytes in patients with large intestine cancer]. 61
6332421 1984
42
[Our experience with emergency surgery in cancer of the large intestine]. 61
6680883 1983
43
Surgery in 932 cases of large intestine cancer. 61
6414771 1983
44
[Possibilities of surgical treatment of large intestine cancer in patients over 70]. 61
6857961 1983
45
Mortality among rubber workers: V. processing workers. 61
7119914 1982
46
[Parenteral feeding in the prevention and treatment of postoperative complications in stomach and large intestine cancer]. 61
6767322 1980
47
Variations in serum copper and ceruloplasmin levels in advanced gastrointestinal cancer treated with polychemotherapy. 61
462583 1979
48
[Possibilities of early diagnosis of large intestine cancer]. 61
1021900 1976
49
Symptoms of large-intestine cancer. 61
4176883 1968
50
[Early diagnosis of large intestine cancer]. 61
5598241 1967

Variations for Large Intestine Cancer

Expression for Large Intestine Cancer

Search GEO for disease gene expression data for Large Intestine Cancer.

Pathways for Large Intestine Cancer

Pathways related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.93 MIR9-1 MIR34A MIR31 MIR21 MIR200A MIR199A1
2 11.43 MIR9-1 MIR21 MIR139 MIR125A
3 10.27 MIR199A1 MIR145

GO Terms for Large Intestine Cancer

Cellular components related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 MIR31 MIR21 MIR199A1 MIR18A MIR17 MIR143
2 extracellular vesicle GO:1903561 9.1 MIR34A MIR21 MIR193A MIR17 MIR126 MIR125A

Biological processes related to Large Intestine Cancer according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.95 MIR34A MIR21 MIR17 MIR125A
2 positive regulation of protein kinase B signaling GO:0051897 9.88 MIR21 MIR199A1 MIR143 MIR126
3 negative regulation of inflammatory response GO:0050728 9.84 MIR31 MIR149 MIR145 MIR126
4 positive regulation of angiogenesis GO:0045766 9.83 MIR31 MIR21 MIR199A1 MIR143 MIR126
5 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.77 MIR21 MIR193A APC
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.72 MIR21 MIR199A1 MIR145
7 miRNA mediated inhibition of translation GO:0035278 9.72 MIR9-1 MIR31 MIR21 MIR17 MIR145
8 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.71 MIR199A1 MIR196A1 MIR193A MIR149
9 negative regulation of sprouting angiogenesis GO:1903671 9.7 MIR34A MIR18A MIR17
10 positive regulation of sprouting angiogenesis GO:1903672 9.69 MIR31 MIR126 MIR125A
11 negative regulation of vascular endothelial cell proliferation GO:1905563 9.67 MIR34A MIR193A MIR126
12 positive regulation of blood vessel endothelial cell migration GO:0043536 9.67 MIR31 MIR200A MIR143 MIR126
13 negative regulation of cardiac muscle hypertrophy GO:0010614 9.66 MIR21 MIR145
14 regulation of smooth muscle contraction GO:0006940 9.65 MIR145 MIR143
15 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.65 MIR34A MIR17
16 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.64 MIR199A1 MIR17
17 positive regulation of connective tissue replacement GO:1905205 9.64 MIR34A MIR199A1
18 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.63 MIR21 MIR125A
19 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR199A1 MIR17
20 negative regulation of cell migration GO:0030336 9.63 MIR9-1 MIR34A MIR21 MIR149 MIR145 MIR126
21 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.62 MIR31 MIR125A
22 positive regulation of metalloendopeptidase activity GO:1904685 9.62 MIR21 MIR17
23 angiotensin-activated signaling pathway GO:0038166 9.61 MIR145 MIR143
24 negative regulation of STAT cascade GO:1904893 9.61 MIR149 MIR125A
25 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.59 MIR21 MIR17
26 aorta smooth muscle tissue morphogenesis GO:0060414 9.58 MIR145 MIR143
27 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.57 MIR17 MIR143
28 regulation of phenotypic switching GO:1900239 9.56 MIR145 MIR143
29 negative regulation of vascular endothelial growth factor production GO:1904046 9.56 MIR34A MIR199A1 MIR17 MIR125A
30 gene silencing by miRNA GO:0035195 9.55 MIR9-1 MIR518A1 MIR34A MIR31 MIR21 MIR200A
31 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.48 MIR145 MIR143
32 negative regulation of interleukin-16 production GO:0032699 9.46 MIR145 MIR125A
33 negative regulation of angiogenesis GO:0016525 9.43 MIR34A MIR21 MIR193A MIR145 MIR143 MIR125A

Molecular functions related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.7 MIR9-1 MIR34A MIR31 MIR21 MIR193A MIR17
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.55 MIR9-1 MIR518A1 MIR34A MIR31 MIR21 MIR200A
3 RNA polymerase II complex binding GO:0000993 9.46 MIR145 MIR139 MIR126 MIR125A

Sources for Large Intestine Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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