Large Intestine Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.

MalaCards based summary: Large Intestine Cancer is related to colorectal cancer and colonic benign neoplasm. An important gene associated with Large Intestine Cancer is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. Affiliated tissues include colon, small intestine and spleen.

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Related Diseases for Large Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer	Intestine Carcinoma in Situ
Rare Carcinoma of Small Intestine

Diseases related to Large Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)

#	Related Disease	Score	Top Affiliating Genes
1	colorectal cancer	32.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
2	colonic benign neoplasm	31.0	MIR21 MIR199A1 MIR18A MIR145 MIR143 H2AC18
3	gastric cancer	30.8	MIR34A MIR30A MIR21 MIR199A1 MIR196A1 MIR17
4	anal canal carcinoma	11.1
5	large intestine adenocarcinoma	11.1
6	anus cancer	11.1
7	cecum carcinoma	11.1
8	nervous system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
9	bladder disease	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
10	lung cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
11	reproductive system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
12	gastrointestinal system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
13	stomach disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
14	lymphatic system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
15	connective tissue disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
16	intestinal disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
17	thoracic cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
18	male reproductive organ cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
19	breast disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
20	central nervous system cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
21	gastrointestinal system cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
22	endocrine system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
23	immune system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
24	pancreas disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
25	hematologic cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
26	cervix disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
27	female reproductive system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
28	connective tissue cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
29	urinary system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
30	respiratory system disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
31	colonic disease	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
32	endocrine gland cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
33	male reproductive system disease	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
34	lymphatic system cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
35	malignant exocrine pancreas neoplasm	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
36	spinal disease	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
37	lymphoma, non-hodgkin, familial	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
38	respiratory system cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
39	uterine anomalies	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
40	hepatocellular carcinoma	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
41	malignant astrocytoma	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
42	cell type benign neoplasm	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
43	biliary tract disease	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
44	oral cavity cancer	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
45	pancreatic ductal adenocarcinoma	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
46	bile duct adenocarcinoma	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
47	head and neck cancer	10.7	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR196A1
48	bone cancer	10.7	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1
49	lung cancer susceptibility 3	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
50	biliary tract cancer	10.7	MIR31 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A

Graphical network of the top 20 diseases related to Large Intestine Cancer:

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Symptoms & Phenotypes for Large Intestine Cancer

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Drugs & Therapeutics for Large Intestine Cancer

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes	Recruiting	NCT04907643	Phase 2
2	GI 1549: PROGRAMS TO SUPPORT YOU DURING CHEMOTHERAPY (PRO-YOU) A Randomized Controlled Pilot Study of Yoga Compared to an Attention Control in Patients Receiving Chemotherapy	Completed	NCT02489422

Search NIH Clinical Center for Large Intestine Cancer

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Genetic Tests for Large Intestine Cancer

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Anatomical Context for Large Intestine Cancer

Organs/tissues related to Large Intestine Cancer:

MalaCards : Colon, Small Intestine, Spleen, Lung

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Publications for Large Intestine Cancer

Articles related to Large Intestine Cancer:

(show top 50) (show all 51)

#	Title	Authors	PMID	Year
1	Subsequent Primary Cancers of the Digestive System Among Childhood and Adolescent Cancer Survivors From 1975 to 2015 in the United States. ⁶²	Liu JJ...Wu CY	33929381	2021
2	Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ⁶²	Ferreira-Lazarte A...Villamiel M	33202274	2021
3	LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3β/β-catenin pathway. ⁶²	Zuo Z...Han J	32749739	2020
4	Cohort study of occupational cosmic radiation dose and cancer mortality in German aircrew, 1960-2014. ⁶²	Dreger S...Zeeb H	32075886	2020
5	Neoplastic sigmoid-uterine fistula. An exceptional complication of large intestine cancer. ⁶²	Zanghi G...Leanza G	28460202	2017
6	Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. ⁶²	Patel NJ...Cohen M	27642112	2016
7	Concentrations of cadmium and selected essential elements in malignant large intestine tissue. ⁶²	Klimczak M...Darago A	27110307	2016
8	[Efficacy evaluation of heat-sensitive moxibustion for chemotherapy symptoms of large intestine cancer]. ⁶²	Li Z...Xie D	26790207	2015
9	[The possibilities of laparoscopic technology in surgical treatment of large intestine cancer]. ⁶²	Aliev SA...Zeinalov BM	24640763	2013
10	Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. ⁶²	Zareba K...Kedra B	23612677	2013
11	Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location. ⁶²	Waniczek D...Lange D	23788900	2012
12	[Optimal methods of rehabilitation of patients after a left-side colostomy]. ⁶²	Ivanishvili TK...Moistsrapishvili MR	19801720	2009
13	[Quantified diagnositic standard for large intestinal cancer of spleen qi deficiency syndrome.]. ⁶²	Hou FG...Yin XL	19747434	2009
14	[Coronary artery disease attack caused by cytotoxic chemotherapy]. ⁶²	Ilveskoski E...Eskola M	19517869	2009
15	Test for obscure bleeding vs colonoscopy in the prevention of colorectal cancer. ⁶²	Mesihovic R...Gribajcevic M	18822943	2008
16	[Restorative surgery in large intestine cancer]. ⁶²	Bondarenko NV...Verchenko IaV	18410013	2007
17	[Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy]. ⁶²	Zhang AP...Luo DL	16620711	2006
18	The diversity expression of p62 in digestive system cancers. ⁶²	Su Y...Peng X	15886058	2005
19	Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. ⁶²	Mao JD...Xu GQ	15655830	2005
20	In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy. ⁶²	Li QB...Wu JG	15637737	2005
21	[Effect of palliative chemotherapy with topoisomerase inhibitor on the quality of life and survival of patients with advanced colorectal carcinoma]. ⁶²	Bucior J...Kempinski M	15754631	2004
22	[Mortality rate in reconstructive plastic surgery in patients with cardiorespiratory diseases]. ⁶²	Bondarenko MV	15318828	2004
23	Antioxidative activity of animal and vegetable dietary fibers. ⁶²	Suzuki N...Yoda B	15630221	2004
24	[Correlation between family and age of manifestation of lung and colon cancer]. ⁶²	Atramentova LA...Beliaeva LV	14964840	2003
25	Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases. ⁶²	Yao GY...Chen PH	12679948	2003
26	[Variations of cellular membrane phospholipids with genesis and hepatic metastasis of large intestine cancer]. ⁶²	Li S...Cai H	12417063	2002
27	[The role of Fas/Fas ligand in tumorgenesis, immune escape, and counterattack in colonic cancer]. ⁶²	Zhu Q...Deng C	12137598	2002
28	[Preparation and in vitro killing effect of adriamycin-loaded immunonanosphere against hepatoma led by F (ab')2 Fragment of monoclonal antibodies]. ⁶²	Li Y...Liang Z	12599415	2002
29	[Efficacy of lidocaine cream in protecting against thermal stress during hyperthermia]. ⁶²	Kobayashi M...Arii K	11201383	2001
30	[Effect of chang'ai kangfu decoction on immunity in postoperational patients with large intestine cancer]. ⁶²	Li H...Tang Z	11789186	2000
31	[N-acetyltransferase genetic polymorphism and its role in the development of neoplastic disease]. ⁶²	Lutz W	11002474	2000
32	Mortality of workers at two asbestos-cement plants in Poland. ⁶²	Szeszenia-Dabrowska N...Szymczak W	10967842	2000
33	[Does fecal occult blood screening result in decreased mortality from large intestine cancer?]. ⁶²	Porschen R...Haack G	9340935	1997
34	Cohort study on cancer mortality among workers in the pulp and paper industry in Catalonia, Spain. ⁶²	Sala-Serra M...Anto JM	8837689	1996
35	Proportionate mortality study of golf course superintendents. ⁶²	Kross BC...Fu CM	8732923	1996
36	[Mortality among workers of the rubber industry. III. Results of further observation of the male cohort]. ⁶²	Szeszenia-Dabrowska N...Sobala W	7476145	1995
37	[Epidemiological data on precancerous conditions and neoplasms among workers in the petroleum-refining industry]. ⁶²	Saprykina AG	2139624	1990
38	[Geographical correlation analysis between schistosomiasis and large intestine cancer]. ⁶²	Li Y	3147814	1988
39	[Early clinical diagnosis of stomach and large intestine cancer]. ⁶²	Peschl L...Munda W	3617781	1987
40	[Surgery of stomach and large intestine cancer in the elderly]. ⁶²	Dinstl K	2437711	1987
41	[Quadruple metachronous large intestine cancer]. ⁶²	Hermann W...Stenzl W	4013539	1985
42	[Plasma retinol, beta-carotene and ascorbic acid levels and functional activity of lymphocytes in patients with large intestine cancer]. ⁶²	Sergeev AV	6332421	1984
43	[Our experience with emergency surgery in cancer of the large intestine]. ⁶²	Di Natale I	6680883	1983
44	Surgery in 932 cases of large intestine cancer. ⁶²	Zhao ES...Zhen BC	6414771	1983
45	[Possibilities of surgical treatment of large intestine cancer in patients over 70]. ⁶²	Mel'nikov RA...Pravosudov IV	6857961	1983
46	Mortality among rubber workers: V. processing workers. ⁶²	Delzell E...Monson RR	7119914	1982
47	[Parenteral feeding in the prevention and treatment of postoperative complications in stomach and large intestine cancer]. ⁶²	Biletov BV	6767322	1980
48	Variations in serum copper and ceruloplasmin levels in advanced gastrointestinal cancer treated with polychemotherapy. ⁶²	Scanni A...Curtarelli G	462583	1979
49	[Possibilities of early diagnosis of large intestine cancer]. ⁶²	Zaitsev VN...Stefanenko IuF	1021900	1976
50	Symptoms of large-intestine cancer. ⁶²	Ginsburg GP	4176883	1968

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Genes for Large Intestine Cancer

Genes related to Large Intestine Cancer (0 elite genes):

(show top 50) (show all 120)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR199A1	MicroRNA 199a-1	RNA Gene	16.6	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
2	MIR21	MicroRNA 21	RNA Gene	13.5	DISEASES inferred ¹⁴ ¹⁴
3	MIR17	MicroRNA 17	RNA Gene	13.41	DISEASES inferred ¹⁴ ¹⁴
4	MIR145	MicroRNA 145	RNA Gene	12.96	DISEASES inferred ¹⁴ ¹⁴
5	MIR143	MicroRNA 143	RNA Gene	12.88	DISEASES inferred ¹⁴ ¹⁴
6	MIR31	MicroRNA 31	RNA Gene	12.81	DISEASES inferred ¹⁴ ¹⁴
7	H2AC18	H2A Clustered Histone 18	Protein Coding	12.57	DISEASES inferred ¹⁴ ¹⁴
8	MIR518A1	MicroRNA 518a-1	RNA Gene	12.5	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
9	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	12.48	DISEASES inferred ¹⁴ ¹⁴
10	MIR193A	MicroRNA 193a	RNA Gene	12.27	DISEASES inferred ¹⁴ ¹⁴
11	MIR139	MicroRNA 139	RNA Gene	12.18	DISEASES inferred ¹⁴ ¹⁴
12	MIR126	MicroRNA 126	RNA Gene	12.14	DISEASES inferred ¹⁴ ¹⁴
13	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	12.13	DISEASES inferred ¹⁴ ¹⁴
14	MIR196A1	MicroRNA 196a-1	RNA Gene	12.06	DISEASES inferred ¹⁴ ¹⁴
15	MIR142	MicroRNA 142	RNA Gene	12.03	DISEASES inferred ¹⁴ ¹⁴
16	MIR34A	MicroRNA 34a	RNA Gene	11.97	DISEASES inferred ¹⁴ ¹⁴
17	MIR125A	MicroRNA 125a	RNA Gene	11.93	DISEASES inferred ¹⁴ ¹⁴
18	MIR18A	MicroRNA 18a	RNA Gene	11.93	DISEASES inferred ¹⁴ ¹⁴
19	MIR149	MicroRNA 149	RNA Gene	11.85	DISEASES inferred ¹⁴ ¹⁴
20	MIR30A	MicroRNA 30a	RNA Gene	11.83	DISEASES inferred ¹⁴ ¹⁴
21	MIR140	MicroRNA 140	RNA Gene	11.81	DISEASES inferred ¹⁴ ¹⁴
22	MIR204	MicroRNA 204	RNA Gene	11.76	DISEASES inferred ¹⁴ ¹⁴
23	MIR221	MicroRNA 221	RNA Gene	11.74	DISEASES inferred ¹⁴ ¹⁴
24	MIR9-1	MicroRNA 9-1	RNA Gene	11.73	DISEASES inferred ¹⁴ ¹⁴
25	MIR155	MicroRNA 155	RNA Gene	11.69	DISEASES inferred ¹⁴ ¹⁴
26	MIR200A	MicroRNA 200a	RNA Gene	11.64	DISEASES inferred ¹⁴ ¹⁴
27	MIR499A	MicroRNA 499a	RNA Gene	11.64	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
28	MIR338	MicroRNA 338	RNA Gene	11.63	DISEASES inferred ¹⁴ ¹⁴
29	MIR150	MicroRNA 150	RNA Gene	11.62	DISEASES inferred ¹⁴ ¹⁴
30	MIR214	MicroRNA 214	RNA Gene	11.57	DISEASES inferred ¹⁴ ¹⁴
31	MIR144	MicroRNA 144	RNA Gene	11.47	DISEASES inferred ¹⁴ ¹⁴
32	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	11.44	DISEASES inferred ¹⁴ ¹⁴
33	MIR92A1	MicroRNA 92a-1	RNA Gene	11.4	DISEASES inferred ¹⁴ ¹⁴
34	MIR29A	MicroRNA 29a	RNA Gene	11.39	DISEASES inferred ¹⁴ ¹⁴
35	MIR141	MicroRNA 141	RNA Gene	11.38	DISEASES inferred ¹⁴ ¹⁴
36	MIR27A	MicroRNA 27a	RNA Gene	11.33	DISEASES inferred ¹⁴ ¹⁴
37	MIR330	MicroRNA 330	RNA Gene	11.31	DISEASES inferred ¹⁴ ¹⁴
38	MIR185	MicroRNA 185	RNA Gene	11.3	DISEASES inferred ¹⁴ ¹⁴
39	MIR590	MicroRNA 590	RNA Gene	11.24	DISEASES inferred ¹⁴ ¹⁴
40	MIR25	MicroRNA 25	RNA Gene	11.16	DISEASES inferred ¹⁴ ¹⁴
41	MIR124-1	MicroRNA 124-1	RNA Gene	11.12	DISEASES inferred ¹⁴ ¹⁴
42	MIR200C	MicroRNA 200c	RNA Gene	11.12	DISEASES inferred ¹⁴ ¹⁴
43	MIR106A	MicroRNA 106a	RNA Gene	11.1	DISEASES inferred ¹⁴ ¹⁴
44	MIR195	MicroRNA 195	RNA Gene	11.1	DISEASES inferred ¹⁴ ¹⁴
45	MIR20A	MicroRNA 20a	RNA Gene	11.08	DISEASES inferred ¹⁴ ¹⁴
46	MIR486-1	MicroRNA 486-1	RNA Gene	11.08	DISEASES inferred ¹⁴ ¹⁴
47	MIR483	MicroRNA 483	RNA Gene	11.08	DISEASES inferred ¹⁴ ¹⁴
48	MIR455	MicroRNA 455	RNA Gene	11.03	DISEASES inferred ¹⁴ ¹⁴
49	MIR106B	MicroRNA 106b	RNA Gene	11.03	DISEASES inferred ¹⁴ ¹⁴
50	MIR423	MicroRNA 423	RNA Gene	11.03	DISEASES inferred ¹⁴ ¹⁴

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Variations for Large Intestine Cancer

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Expression for Large Intestine Cancer

Search GEO for disease gene expression data for Large Intestine Cancer.

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Pathways for Large Intestine Cancer

Pathways related to Large Intestine Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.35	MIR199A1 MIR17 MIR145 MIR143
2	miRNAs involved in DNA damage response ⁷⁴	11.18	MIR21 MIR18A MIR17 MIR145 MIR143
3	miRNAs involvement in the immune response in sepsis ⁷⁴	10.81	MIR21 MIR199A1 MIR149 MIR145 MIR126

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GO Terms for Large Intestine Cancer

Cellular components related to Large Intestine Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.9	MIR31 MIR30A MIR21 MIR199A1 MIR18A MIR17
2	RISC complex	GO:0016442	9.75	MIR125A MIR126 MIR139 MIR142 MIR143 MIR145
3	extracellular vesicle	GO:1903561	9.5	MIR34A MIR30A MIR21 MIR193A MIR17 MIR126

Biological processes related to Large Intestine Cancer according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	10.03	MIR34A MIR21 MIR199A1 MIR17 MIR125A
2	positive regulation of protein kinase B signaling	GO:0051897	9.89	MIR21 MIR199A1 MIR143 MIR126
3	negative regulation of cell migration	GO:0030336	9.88	MIR126 MIR145 MIR149 MIR21 MIR31 MIR34A
4	positive regulation of angiogenesis	GO:0045766	9.85	MIR31 MIR30A MIR21 MIR199A1 MIR143 MIR126
5	miRNA-mediated gene silencing	GO:0035195	9.8	MIR125A MIR126 MIR139 MIR142 MIR143 MIR145
6	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.76	MIR31 MIR30A MIR143 MIR126
7	negative regulation of cardiac muscle cell apoptotic process	GO:0010667	9.75	MIR21 MIR199A1 MIR145
8	positive regulation of sprouting angiogenesis	GO:1903672	9.73	MIR31 MIR126 MIR125A
9	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.73	MIR199A1 MIR196A1 MIR193A MIR149
10	negative regulation of inflammatory response	GO:0050728	9.73	MIR31 MIR199A1 MIR149 MIR145 MIR142 MIR126
11	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.72	MIR31 MIR21 MIR17 MIR145 MIR126
12	negative regulation of sprouting angiogenesis	GO:1903671	9.7	MIR34A MIR18A MIR17
13	negative regulation of vascular endothelial cell proliferation	GO:1905563	9.69	MIR34A MIR193A MIR126
14	angiotensin-activated signaling pathway	GO:0038166	9.64	MIR145 MIR143
15	positive regulation of connective tissue replacement	GO:1905205	9.63	MIR34A MIR199A1
16	negative regulation of angiogenesis	GO:0016525	9.63	MIR125A MIR143 MIR145 MIR193A MIR21 MIR34A
17	negative regulation of receptor signaling pathway via STAT	GO:1904893	9.62	MIR149 MIR125A
18	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.62	MIR199A1 MIR17
19	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.61	MIR21 MIR17
20	aorta smooth muscle tissue morphogenesis	GO:0060414	9.61	MIR145 MIR143
21	positive regulation of metalloendopeptidase activity	GO:1904685	9.6	MIR21 MIR17
22	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.58	MIR31 MIR125A
23	regulation of phenotypic switching	GO:1900239	9.57	MIR143 MIR145
24	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.55	MIR17 MIR143
25	positive regulation of cellular response to hypoxia	GO:1900039	9.54	MIR21 MIR145
26	establishment or maintenance of cell type involved in phenotypic switching	GO:0044663	9.49	MIR145 MIR143
27	negative regulation of interleukin-16 production	GO:0032699	9.48	MIR145 MIR125A
28	negative regulation of vascular endothelial growth factor production	GO:1904046	9.26	MIR34A MIR199A1 MIR17 MIR125A

Molecular functions related to Large Intestine Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.77	MIR34A MIR31 MIR30A MIR21 MIR199A1 MIR193A
2	mRNA base-pairing translational repressor activity	GO:1903231	9.55	MIR518A1 MIR34A MIR31 MIR30A MIR21 MIR199A1

Sources

Sources for Large Intestine Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

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¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRG017 MIFTS: 33	Large Intestine Cancer Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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