Large Intestine Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Large Intestine Cancer

MalaCards integrated aliases for Large Intestine Cancer:

Name: Large Intestine Cancer 12 15
Colorectal Neoplasms 43
Colorectal Neoplasm 17


External Ids:

Disease Ontology 12 DOID:5672
MeSH 43 D015179
SNOMED-CT 67 93854002
ICD10 32 C18.9
UMLS 71 C0009402 C0346629 C1319315

Summaries for Large Intestine Cancer

Disease Ontology : 12 An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.

MalaCards based summary : Large Intestine Cancer, also known as colorectal neoplasms, is related to colorectal cancer and colorectal adenoma. An important gene associated with Large Intestine Cancer is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Parkinsons Disease Pathway. The drugs Phylloquinone and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes.

Related Diseases for Large Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ
Rare Carcinoma of Small Intestine

Diseases related to Large Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 33.5 MIR9-1 MIR34A MIR31 MIR30A MIR21 MIR200A
2 colorectal adenoma 32.1 MIR21 MIR17 APC
3 non-alcoholic fatty liver disease 31.6 MIR34A MIR31 MIR30A MIR21 MIR200A MIR17
4 arteries, anomalies of 31.4 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
5 coronary artery anomaly 31.3 MIR21 MIR199A1 MIR145 MIR126
6 colonic disease 31.3 MIR9-1 MIR34A MIR31 MIR30A MIR21 MIR200A
7 intestinal disease 31.3 MIR9-1 MIR518A1 MIR34A MIR31 MIR30A MIR21
8 in situ carcinoma 31.2 MIR30A MIR17 MIR143 MIR142 MIR139 H2AC18
9 body mass index quantitative trait locus 11 31.2 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR18A
10 gastric cancer 31.1 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR196A1
11 rectum cancer 31.0 MIR518A1 MIR31 MIR21 MIR200A MIR196A1 MIR17
12 vascular disease 30.9 MIR21 MIR199A1 MIR145 MIR143 MIR126 MIR125A
13 gastrointestinal system cancer 30.9 MIR9-1 MIR518A1 MIR34A MIR31 MIR30A MIR21
14 diabetes mellitus, noninsulin-dependent 30.9 MIR30A MIR21 MIR199A1 MIR196A1 MIR17 MIR142
15 coronary heart disease 1 30.6 MIR17 MIR145 MIR126
16 lynch syndrome 11.9
17 large intestine adenocarcinoma 11.2
18 anus cancer 11.2
19 tongue disease 10.9 MIR30A MIR21 MIR199A1 MIR196A1 MIR18A MIR17
20 intestinal benign neoplasm 10.9 MIR31 MIR21 MIR199A1 MIR18A MIR17 MIR143
21 ovary epithelial cancer 10.9 MIR30A MIR21 MIR200A MIR199A1 MIR196A1 MIR17
22 laryngeal disease 10.9 MIR34A MIR21 MIR196A1 MIR17 MIR143 MIR142
23 malignant ovarian surface epithelial-stromal neoplasm 10.9 MIR30A MIR21 MIR200A MIR199A1 MIR196A1 MIR17
24 gastrointestinal system benign neoplasm 10.9 MIR31 MIR21 MIR199A1 MIR196A1 MIR18A MIR17
25 mouth disease 10.9 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
26 bile duct adenocarcinoma 10.9 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR17
27 autosomal genetic disease 10.9 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR17 MIR142
28 disease of mental health 10.9 MIR9-1 MIR30A MIR21 MIR199A1 MIR17 MIR142
29 bone inflammation disease 10.9 MIR34A MIR30A MIR21 MIR199A1 MIR196A1 MIR17
30 connective tissue cancer 10.9 MIR9-1 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
31 glucose metabolism disease 10.9 MIR9-1 MIR30A MIR21 MIR199A1 MIR196A1 MIR17
32 thyroid gland disease 10.9 MIR9-1 MIR30A MIR21 MIR199A1 MIR196A1 MIR17
33 ovarian serous carcinoma 10.9 MIR21 MIR200A MIR199A1 MIR145 MIR143 MIR125A
34 oral squamous cell carcinoma 10.9 MIR9-1 MIR34A MIR31 MIR21 MIR199A1 MIR17
35 endocrine organ benign neoplasm 10.9 MIR21 MIR199A1 MIR196A1 MIR17 MIR142 MIR139
36 pancreatic ductal adenocarcinoma 10.9 MIR31 MIR21 MIR199A1 MIR196A1 MIR18A MIR145
37 upper respiratory tract disease 10.9 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
38 nasopharyngeal disease 10.9 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
39 oral cavity cancer 10.9 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
40 biliary tract disease 10.9 MIR9-1 MIR31 MIR30A MIR200A MIR199A1 MIR196A1
41 diffuse large b-cell lymphoma 10.9 MIR21 MIR199A1 MIR18A MIR17 MIR145 MIR143
42 bile duct disease 10.9 MIR9-1 MIR31 MIR30A MIR200A MIR199A1 MIR196A1
43 pharynx cancer 10.9 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
44 cardiovascular system disease 10.9 MIR34A MIR21 MIR199A1 MIR17 MIR145 MIR143
45 larynx cancer 10.9 MIR34A MIR31 MIR21 MIR196A1 MIR17 MIR143
46 overnutrition 10.9 MIR9-1 MIR34A MIR21 MIR199A1 MIR196A1 MIR18A
47 inherited metabolic disorder 10.9 MIR9-1 MIR21 MIR199A1 MIR17 MIR142 MIR126
48 bone marrow cancer 10.9 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
49 central nervous system cancer 10.9 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
50 cell type benign neoplasm 10.9 MIR31 MIR21 MIR200A MIR199A1 MIR196A1 MIR18A

Graphical network of the top 20 diseases related to Large Intestine Cancer:

Diseases related to Large Intestine Cancer

Symptoms & Phenotypes for Large Intestine Cancer

Drugs & Therapeutics for Large Intestine Cancer

Drugs for Large Intestine Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 669)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Phylloquinone Approved, Investigational Phase 4 84-80-0
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
Sodium citrate Approved, Investigational Phase 4 68-04-2
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
Magnesium citrate Approved Phase 4 3344-18-1
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Darbepoetin alfa Approved, Investigational Phase 4 209810-58-2, 11096-26-7
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Ferrous fumarate Approved Phase 4 141-01-5
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
Colistin Approved Phase 4 1066-17-7, 1264-72-8 5311054
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
23 Menaquinone Investigational Phase 4 1182-68-9
24 Ferric Oxide, Saccharated Phase 4
25 Vitamin K Phase 4
26 Vitamin K 1 Phase 4
27 naphthoquinone Phase 4
28 Erythromycin Ethylsuccinate Phase 4
29 Erythromycin Estolate Phase 4
30 Erythromycin stearate Phase 4
31 silymarin Phase 4
32 Pharmaceutical Solutions Phase 4
33 Iron Supplement Phase 4
34 Hepcidins Phase 4
35 Ferric Compounds Phase 4
36 Omega 3 Fatty Acid Phase 4
37 Citrate Phase 4
38 Defensins Phase 4
39 glutamine Phase 4
40 Triamcinolone diacetate Phase 4
41 Triamcinolone hexacetonide Phase 4
42 triamcinolone acetonide Phase 4
43 calcium heparin Phase 4
44 Epoetin alfa Phase 4 113427-24-0
45 Nutrients Phase 4
46 Trace Elements Phase 4
47 Micronutrients Phase 4
48 Pirinitramide Phase 4
49 Polyethylene glycol 3350 Phase 4
50 Coagulants Phase 4

Interventional clinical trials:

(show top 50) (show all 3144)
# Name Status NCT ID Phase Drugs
1 Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Study of New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
3 A Prospective,Randomized Control Trial of Intraoperative Intraportal Chemotherapy (5-FU and Oxaliplatin) Combined With Adjuvant Chemotherapy to Prevent Liver Metastasis in Patients Receiving Curative Colorectal Cancer Resection. Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
4 Phase 4 of Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
5 Preoperative Assessment of Colon Tumor: A Prospective, Blinded Study. Unknown status NCT00114829 Phase 4
6 Raltitrexed and Oxaliplatin and Lipiodol Transcatheter Arterial Chemoembolization for Advanced Colorectal Cancer Unknown status NCT01959061 Phase 4 Raltitrexed;Oxaliplatin;lipiodol
7 TAC vs TACE Plus folfox4 as the Treatment of Unresectalbe Liver Metastasis of Colorectal Cancer With Resection of the Primary Tumor: a Prospective, Randomized, Control Trial Unknown status NCT00868569 Phase 4
8 Preoperative Transhepatic Arterial Chemotherapy in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
9 Study of Cetuximab in Combination With Chemotherapy for the First Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
10 NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
11 Maintenance Treatment With Capecitabine Metronomic Chemotherapy and Chinese Traditional Medicine in Metastatic Colorectal Cancer Unknown status NCT02575378 Phase 4 Metronimic chemotherapy plus Chinese Traditional Medicine;Metronimic chemotherapy
12 The Efficacy of Silymarin as Adjuvant Therapy on Colorectal Cancer Patients Undergoing FOLFIRI Treatment Unknown status NCT03130634 Phase 4 Silymarin
13 A Randomized Study Of Continuous FOLFOX4 vs. FOLFOX4 in a Stop-and-Go Fashion in 1st Line Advanced Colorectal Cancer Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
14 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Continuing or Discontinuing on Aspirin: a Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Trial Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
15 Non-randomized Phase-IV-study to Investigate the Efficacy of FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
16 Assessment of the Participation Rate and the Diagnostic Accuracy of a Colorectal Cancer Screening Program: CT Colonography Versus Flexible Sigmoidoscopy. Evaluation of a New Model Based on Telediagnosis Unknown status NCT01739608 Phase 4
17 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-protocol is Identical to Study No. 0519-10-TLV- Minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
18 Erythromycin as a Novel Therapy Against Familial Adenomatous Polyposis and Sporadic Colorectal Cancer by APC Nonsense Mutation Readthrough. Unknown status NCT02175914 Phase 4 Erythromycin
19 The Impact of Treatment of Anaemia With Intravenous Iron on Haematological Values for Patients After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
20 An Open Label Study of Intravenous Iron (FERINJECT) in Colorectal Adenocarcinoma Related Anaemia to Identify Potential Biomarkers of Responsiveness to Intravenous Iron Completed NCT02057471 Phase 4 Intravenous ferric carboxymaltose
21 Pharmacogenomics Blood Sampling Protocol For Irinotecan/Fluorouracil/Leucovorin(CPT-11/FU/LV). Completed NCT00140036 Phase 4
22 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
23 Assessment the Effect of Medium-Calorie TPN on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
24 A Multi-centre, Randomised, Investigator-blinded Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate) Completed NCT01689792 Phase 4 MOVIPREP;CitraFleet
25 Contribution to the Study of Inflammatory Response in Laparoscopic vs Open Colon Cancer Surgery Completed NCT00942461 Phase 4
26 Study of the Oxidative Stress in Patients With Colorectal Cancer. Open vs Laparoscopic Approach Completed NCT00928928 Phase 4
27 MR Colonography With Fecal Tagging: A Prospective, Randomized Study Completed NCT00114842 Phase 4
28 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥75 Years) Completed NCT00812864 Phase 4 Capecitabine
29 Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions Completed NCT00473980 Phase 4 Indomethacin, celecoxib, esomeprazole
30 An Open-label Study of the Safety, Tolerability, and Response Rate of Xeloda in Treatment-naïve Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
31 Multi-center, Randomized Comparison Study to eVALUatE Outcomes and Resource Needs of Imaging and Treatment Following Primovist-enhanced MRI of the Liver in Comparison to Extracellular Contrast Media (ECCM)-Enhanced MRI and Contrast-enhanced Computed Tomography (CT) in Patients With a History of Colorectal Cancer and Known or Suspected Metachronous Liver Metastases. Completed NCT00764621 Phase 4
32 Pilot Study: Randomized Controlled Trial on the Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors Completed NCT00168987 Phase 4 oral nutritional supplement rich in eicosapentanoic acid
33 Study of Avastin in Combination With Chemotherapy for the First Line Treatment of RAS Mutant Unresectable Colorectal Liver-limited Metastases Completed NCT01972490 Phase 4 avastin;mFOLFOX6
34 Protocole Evaluant Chez Des Patients Porteurs de Cancers Colorectaux Metastatiques l'Interet Des Determinants Genotypiques Pour l'Optimisation de l'Efficacite et de la Tolerance de la Chimiotherapie Par Irinotecan et 5-fluorouracile Completed NCT00138060 Phase 4 irinotecan;5 fluorouracil
35 Phase 4 Study to Evaluate Correlation of Overall Response According to RECIST-conventional Imaging Techniques, Morphologic Response by CT, & Histopathologic Response in Patients With Hepatic Metastasis Secondary to Colorectal Cancer With Bevacizumab in Combination With XELOX Completed NCT01493713 Phase 4
36 Effectiveness of Colon Capsule Endoscopy as Colorectal Cancer Method of Screening in The Familiar-Risk Population Completed NCT01557101 Phase 4
37 Phase IV Clinical Study of Safety and Tolerability of Oral Xeloda (Capecitabine) in Adjuvant Treatment of Resected Cancer of the Colon Completed NCT02581423 Phase 4 Capecitabine
38 Preoperative Assessment for Synchronous Carcinoma or Polyps With MR Colonography in Patients With Obstructing Cancer. A Prospective Study. Completed NCT00300547 Phase 4
39 MR Colonography With Fecal Tagging. Barium vs. BariumFerumoxsil Completed NCT00332943 Phase 4
40 The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib in Patients With Metastatic Colorectal Cancer (mCRC) or Gastrointestinal Stromal Tumour (GIST) Completed NCT02800330 Phase 4 Esomeprazole 40mg concomitantly;Esomeprazole 40mg before;Regorafenib 160mg or 120mg
41 Increasing CRC Screening in Health Plan Members Completed NCT00134589 Phase 4
42 An Australian Translational Study to Evaluate the Prognostic Role of Inflammatory Markers in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab (Avastin™) Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
43 Phase 4 Study to Characterize and Evaluate Markers of Chemoresistance in Patients With Metastatic Colorectal Cancer Completed NCT00559676 Phase 4 capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
44 A Multi-Center, Single-Arm, Pilot Study of 5-FU Based Doublet Chemotherapy Plus Bevacizumab as Neoadjuvant Therapy for Patients With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
45 The Effect of Darbepoetin Alfa Treatment Upon the Rehabilitation Following Planned Surgery for Colorectal Cancer Completed NCT00122720 Phase 4 Darbepoetin Alfa
46 Postoperative folfox4 Only vs folfox4 Plus TAC in the Treatment Unresectable Liver Metastasis of Colorectal Cancer: a Randomized,Prospective,Control Trial Completed NCT00869271 Phase 4
47 A Prospective, Randomized, Control Trial of Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles vs 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
48 Does Hemodynamic Optimization During and After Colorectal Surgery Result in Improved Intestinal Perfusion, Sustained Intestinal Barrier and Improved Postoperative Recovery? Completed NCT01175317 Phase 4
49 Impact of Probiotics on the Intestinal Microbiota and Its Association With Postoperative Outcome After Colorectal Surgery Completed NCT01609660 Phase 4
50 Comparative Efficacy of Water & Indigo Carmine vs Water or Air Method Completed NCT01607255 Phase 4 Indigo carmine

Search NIH Clinical Center for Large Intestine Cancer

Cochrane evidence based reviews: colorectal neoplasms

Genetic Tests for Large Intestine Cancer

Anatomical Context for Large Intestine Cancer

MalaCards organs/tissues related to Large Intestine Cancer:

Liver, Colon, Testes, Lung, Breast, Skin, Lymph Node

Publications for Large Intestine Cancer

Articles related to Large Intestine Cancer:

(show top 50) (show all 1236)
# Title Authors PMID Year
The location of premalignant colorectal polyps under age 50: a further rationale for screening sigmoidoscopy. 61
31930456 2020
Plausibility of an extensive use of stool DNA test for screening advanced colorectal neoplasia. 61
31816287 2020
Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas. 61
31028155 2020
Performance of individual and joint risk stratification by an environmental risk score and a genetic risk score in a colorectal cancer screening setting. 61
30868574 2020
Optimal Surveillance Frequency After CRS/HIPEC for Appendiceal and Colorectal Neoplasms: A Multi-institutional Analysis of the US HIPEC Collaborative. 61
31243668 2020
Single dose aspirin affects fecal immunohistochemical test sensitivity in detecting advanced colorectal neoplasms: Truth or expectation? 61
32009620 2020
A Call for a Reconsideration of the Use of Fecal Occult Blood Testing in Emergency Medicine. 61
31926780 2020
Appendix Tumor Microenvironment. 61
32030678 2020
Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection. 61
31887810 2020
GMrepo: a database of curated and consistently annotated human gut metagenomes. 61
31504765 2020
Multiplex quantitation of 270 plasma protein markers to identify a signature for early detection of colorectal cancer. 61
31972396 2020
How to identify patients who are less likely to have metachronous neoplasms after a colon cancer: a predictive model. 61
31858510 2019
[Morphomolecular characterization of colorectal neoplasms]. 61
31705232 2019
A risk-prediction model for en bloc resection failure or perforation during endoscopic submucosal dissection of colorectal neoplasms. 61
31883411 2019
Endoscopic submucosal dissection for colorectal laterally spreading tumors with the Dual knife only. 61
31908694 2019
No evidence for increased prevalence of colorectal carcinoma in 399 Dutch patients with Birt-Hogg-Dubé syndrome. 61
31857718 2019
Discrimination between Human Colorectal Neoplasms with a Dual-Recognitive Two-Photon Probe. 61
31650833 2019
Efficacy of Difluoromethylornithine and Aspirin for Treatment of Adenomas and Aberrant Crypt Foci in Patients with Prior Advanced Colorectal Neoplasms. 61
31484660 2019
Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma. 61
31209633 2019
Relationship between Barrett's esophagus and colonic diseases: a role for colonoscopy in Barrett's surveillance. 61
31240437 2019
High-Yield Methylation Markers for Stool-Based Detection of Colorectal Cancer. 61
31720923 2019
Identification and Validation of MicroRNA Profiles in Fecal Samples for Detection of Colorectal Cancer. 61
31622624 2019
Endoscopic Assessment of the Malignant Potential of the Nonpolypoid (Flat and Depressed) Colorectal Neoplasms: Thinking Fast, and Slow. 61
31445686 2019
A novel panel of stool-based DNA biomarkers for early screening of colorectal neoplasms in a Chinese population. 61
31456088 2019
Endoscopic submucosal dissection of colorectal neoplasms: an audit of its safety and efficacy in a single tertiary centre in Singapore. 61
30773601 2019
Developments in the study of gastrointestinal microbiome disorders affected by FGF19 in the occurrence and development of colorectal neoplasms. 61
31637718 2019
Can Advanced Endoscopic Imaging Help Us Avoid Surgery for Endoscopically Resectable Colorectal Neoplasms? A Proof-of-Concept Study. 61
31630341 2019
Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy. 61
31594962 2019
Outcomes following colonic stenting for malignant left-sided bowel obstruction: a systematic review of randomised controlled trials. 61
31475316 2019
Perioperative and long-term outcomes of laparoscopic liver resections for non-colorectal liver metastases. 61
31586246 2019
Use of Phosphodiesterase 5 Inhibitors Is Associated With Lower Risk of Colorectal Cancer in Men With Benign Colorectal Neoplasms. 61
31103628 2019
Usefulness of "Nelaton Attachment" for endoscopic submucosal dissection of colorectal neoplasms. 61
31475238 2019
Head-to-Head Comparison of the Performance of 17 Risk Models for Predicting Presence of Advanced Neoplasms in Colorectal Cancer Screening. 61
31464746 2019
Randomized clinical trial of accelerated enhanced recovery after minimally invasive colorectal cancer surgery (RecoverMI trial). 61
31216065 2019
Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms. 61
31525512 2019
The effect of anticoagulants on delayed bleeding after colorectal endoscopic submucosal dissection. 61
31482349 2019
Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study. 61
31592060 2019
Participation and yield of a population-based colorectal cancer screening programme in China. 61
30377193 2019
An enrichment model using regular health examination data for early detection of colorectal cancer. 61
31564811 2019
Saline-pocket endoscopic submucosal dissection for superficial colorectal neoplasms: a randomized controlled trial (with video). 61
30930074 2019
Aspirin before fecal immunochemical testing did not increase sensitivity for detecting advanced colorectal neoplasms. 61
31426063 2019
Reliability of Japan Narrow-Band Imaging Expert Team Classification for the Diagnosis of Colorectal Neoplasms: A Pilot Study. 61
31394529 2019
Diagnostic yield of the Japan NBI Expert Team (JNET) classification for endoscopic diagnosis of superficial colorectal neoplasms in a large-scale clinical practice database. 61
31428416 2019
The Diagnostic Performance for Colorectal Neoplasms Using Magnified Endoscopy Differs between Experts and Novice Endoscopists: A Post Hoc Analysis. 61
31311019 2019
Prevalence of Colorectal Neoplasms and Mortality in New Users of Low-Dose Aspirin With Lower Gastrointestinal Bleeding. 61
31356342 2019
Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway. 61
31358825 2019
Assessment of beta-catenin expression by immunohistochemistry in colorectal neoplasms and its role as an additional prognostic marker in colorectal adenocarcinoma. 61
31460505 2019
Efficacy of linked colour imaging in magnifying chromoendoscopy with crystal violet staining: a pilot study. 61
31168654 2019
Whole-blood DNA Methylation Markers for Risk Stratification in Colorectal Cancer Screening: A Systematic Review. 61
31261771 2019
[Progress in construction and verification of colorectal cancer risk prediction models: a systematic review]. 61
31177758 2019

Variations for Large Intestine Cancer

Expression for Large Intestine Cancer

Search GEO for disease gene expression data for Large Intestine Cancer.

Pathways for Large Intestine Cancer

Pathways related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.96 MIR9-1 MIR34A MIR31 MIR30A MIR21 MIR200A
2 11.06 MIR30A MIR18A MIR17
3 10.27 MIR199A1 MIR145

GO Terms for Large Intestine Cancer

Cellular components related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 MIR31 MIR30A MIR21 MIR199A1 MIR18A MIR17

Biological processes related to Large Intestine Cancer according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.83 MIR21 MIR199A1 MIR143 MIR126
2 positive regulation of angiogenesis GO:0045766 9.73 MIR31 MIR30A MIR21 MIR199A1 MIR143 MIR126
3 negative regulation of angiogenesis GO:0016525 9.72 MIR34A MIR21 MIR145 MIR143 MIR125A
4 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.65 MIR21 MIR199A1 MIR145
5 negative regulation of sprouting angiogenesis GO:1903671 9.63 MIR34A MIR18A MIR17
6 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.61 MIR21 MIR17
7 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.61 MIR34A MIR17
8 negative regulation of cardiac muscle hypertrophy GO:0010614 9.6 MIR21 MIR145
9 regulation of smooth muscle contraction GO:0006940 9.59 MIR145 MIR143
10 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.58 MIR199A1 MIR17
11 positive regulation of connective tissue replacement GO:1905205 9.58 MIR34A MIR199A1
12 positive regulation of sprouting angiogenesis GO:1903672 9.58 MIR31 MIR126 MIR125A
13 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.57 MIR199A1 MIR17
14 positive regulation of metalloendopeptidase activity GO:1904685 9.56 MIR21 MIR17
15 angiotensin-activated signaling pathway GO:0038166 9.55 MIR145 MIR143
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.55 MIR31 MIR30A MIR200A MIR143 MIR126
17 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.54 MIR21 MIR17
18 aorta smooth muscle tissue morphogenesis GO:0060414 9.51 MIR145 MIR143
19 gene silencing by miRNA GO:0035195 9.5 MIR9-1 MIR518A1 MIR34A MIR31 MIR30A MIR21
20 regulation of phenotypic switching GO:1900239 9.49 MIR145 MIR143
21 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.43 MIR17 MIR143
22 miRNA mediated inhibition of translation GO:0035278 9.43 MIR9-1 MIR31 MIR30A MIR21 MIR17 MIR145
23 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.37 MIR145 MIR143

Molecular functions related to Large Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.5 MIR9-1 MIR518A1 MIR34A MIR31 MIR30A MIR21
2 RNA polymerase II complex binding GO:0000993 9.26 MIR145 MIR139 MIR126 MIR125A

Sources for Large Intestine Cancer

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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