Laryngeal Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Laryngeal Benign Neoplasm

MalaCards integrated aliases for Laryngeal Benign Neoplasm:

Name: Laryngeal Benign Neoplasm ¹² ¹⁵

Neoplasm of Larynx ¹²

Laryngeal Tumor ¹²

Larynx Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2598

MeSH ⁴³ D007822

NCIt ⁴⁹ C3156

UMLS ⁷¹ C0023055

Sources

Summaries for Laryngeal Benign Neoplasm

MalaCards based summary : Laryngeal Benign Neoplasm, also known as neoplasm of larynx, is related to supraglottis cancer and papilloma. An important gene associated with Laryngeal Benign Neoplasm is MIR106B (MicroRNA 106b), and among its related pathways/superpathways are DNA Damage Response and Proteoglycans in cancer. Affiliated tissues include breast, lung and skin, and related phenotype is neoplasm.

Sources

Related Diseases for Laryngeal Benign Neoplasm

Diseases related to Laryngeal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)

#	Related Disease	Score	Top Affiliating Genes
1	supraglottis cancer	30.5	SERPINB3 PDPN MMP8 EGFR CDKN2A
2	papilloma	30.1	TP53 EGFR CDKN2A CCND1
3	hypopharynx cancer	29.9	TP53 SERPINB3 MMP8 EGFR CDKN2A
4	laryngeal squamous cell carcinoma	29.9	TP53 MIR21 EGFR CDKN2A CCND1
5	larynx cancer	29.8	TP53 SERPINB3 MIR21 MIR106B EGFR CDKN2A
6	mucoepidermoid carcinoma	29.5	TP53 EGFR CDKN2A CCND1
7	squamous cell carcinoma	28.7	TP53 SERPINB3 PDPN EGFR CDKN2A CCND1
8	bladder cancer	28.7	TP53 MIR21 MIR106B EGFR CDKN2A CCND1
9	laryngeal disease	28.4	TP53 SERPINB3 PDPN MMP8 MIR21 MIR106B
10	larynx leiomyoma	11.4
11	laryngeal neuroendocrine tumor	11.3
12	laryngeal adenoid cystic carcinoma	10.6	SERPINB3 MMP8
13	vulvar intraepithelial neoplasia	10.5	TP53 CDKN2A
14	anal carcinoma in situ	10.5	TP53 SERPINB3
15	malignant peritoneal mesothelioma	10.5	EGFR CDKN2A
16	subglottis neoplasm	10.5	SERPINB3 PDPN
17	ovarian seromucinous carcinoma	10.5	TP53 CDKN2A
18	orbital lymphangioma	10.5	PDPN EGFR
19	spitz nevus	10.5	TP53 CDKN2A
20	parotid gland cancer	10.5	TP53 SERPINB3
21	esophageal basaloid squamous cell carcinoma	10.5	TP53 EGFR
22	frontal lobe neoplasm	10.4	TP53 EGFR
23	gallbladder adenoma	10.4	PDPN CDKN2A
24	xanthogranulomatous cholecystitis	10.4	TP53 PDPN
25	soft tissue sarcoma	10.4	TP53 EGFR
26	keratinizing squamous cell carcinoma	10.4	TP53 EGFR CDKN2A
27	rectal disease	10.4	TP53 SERPINB3 CDKN2A
28	adenocarcinoma in situ	10.4	MIR21 EGFR CDKN2A
29	supraglottis neoplasm	10.4	SERPINB3 PDPN MMP8
30	papillary squamous carcinoma	10.4	EGFR CDKN2A
31	atypical neurofibroma	10.4	PDPN CDKN2A
32	vulvar disease	10.4	TP53 EGFR CDKN2A
33	peritoneum cancer	10.4	TP53 EGFR CDKN2A
34	suppressor of tumorigenicity 3	10.4	TP53 CDKN2A
35	supratentorial cancer	10.4	TP53 EGFR CDKN2A
36	gliomatosis cerebri	10.4	TP53 EGFR CDKN2A
37	basaloid squamous cell carcinoma	10.4	TP53 EGFR CDKN2A
38	epiglottis cancer	10.4	PDPN MMP8
39	fibrillary astrocytoma	10.4	TP53 EGFR CDKN2A
40	breast malignant phyllodes tumor	10.4	TP53 EGFR
41	microinvasive gastric cancer	10.4	TP53 SERPINB3 PDPN
42	luminal breast carcinoma	10.4	TP53 MIR21 EGFR
43	lung adenoma	10.4	TP53 EGFR CDKN2A
44	chronic cervicitis	10.4	TP53 CDKN2A
45	signet ring cell adenocarcinoma	10.4	TP53 SERPINB3 PDPN
46	lip cancer	10.4	TP53 PDPN MMP8
47	uterine corpus cancer	10.4	TP53 EGFR CDKN2A
48	ovarian cystadenocarcinoma	10.4	TP53 EGFR CDKN2A
49	pancreatic ductal carcinoma	10.4	TP53 EGFR CDKN2A
50	endocrine organ benign neoplasm	10.3	TP53 MIR21 MIR106B

Graphical network of the top 20 diseases related to Laryngeal Benign Neoplasm:

Sources

Symptoms & Phenotypes for Laryngeal Benign Neoplasm

MGI Mouse Phenotypes related to Laryngeal Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.17	ASAP1 CCND1 CDKN2A EGFR MMP8 TP53

Sources

Drugs & Therapeutics for Laryngeal Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID
1	Quality of Life After Laser Cordectomy in Early Glottic Cancer	Unknown status	NCT02184403
2	Comparison of Video-Laryngoscope Versus a Combination of a Video-Laryngoscope and Disposable Bronchoscope for Predicted Difficult Airway Intubation of Anesthetized Patients for Oral Cavity, Pharynx or Larynx Surgery	Recruiting	NCT03080896
3	CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions	Not yet recruiting	NCT03214835
4	Role of Ultrasound in Diagnosis of Laryngeal Lesions	Not yet recruiting	NCT03450694

Search NIH Clinical Center for Laryngeal Benign Neoplasm

Sources

Genetic Tests for Laryngeal Benign Neoplasm

Sources

Anatomical Context for Laryngeal Benign Neoplasm

MalaCards organs/tissues related to Laryngeal Benign Neoplasm:

⁴⁰

Breast, Lung, Skin, Tongue, Bone, Thyroid, Colon

Sources

Publications for Laryngeal Benign Neoplasm

Articles related to Laryngeal Benign Neoplasm:

#	Title	Authors	PMID	Year
1	Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ⁶¹	Novakovic D...Brotherton JM	27074766	2016
2	Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. ⁶¹	Conti S...Cernigliaro A	24968910	2014
3	Moderately differentiated neuroendocrine carcinoma of the larynx. ⁶¹	Chung EJ...Jung KY	19434271	2008
4	[Influence executed of occupation on self-evaluation disorders of voice]. ⁶¹	Ratajczak J...Jurkiewicz D	18552035	2007
5	[Mortality of men with occupational lead poisoning in Poland]. ⁶¹	Wilczynska U...Sobala W	9695059	1998
6	Neoplasm of Larynx. ⁶¹	Howarth W...Mill WA	19988475	1931
7	Case of ? Neoplasm of Larynx. ⁶¹	Mollison WM	19981052	1920
8	Case of ? Neoplasm of Larynx. ⁶¹	Mollison WM	20905449	1920

Sources

Genes for Laryngeal Benign Neoplasm

Genes related to Laryngeal Benign Neoplasm (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR106B	MicroRNA 106b	RNA Gene	7.05	DISEASES inferred ¹⁵ ¹⁵
2	MIR21	MicroRNA 21	RNA Gene	6.7	DISEASES inferred ¹⁵ ¹⁵
3	SERPINB3	Serpin Family B Member 3	Protein Coding	6.27	DISEASES inferred ¹⁵
4	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.06	DISEASES inferred ¹⁵
5	TREX2	Three Prime Repair Exonuclease 2	Protein Coding	5.84	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	5.78	DISEASES inferred ¹⁵
7	MMP8	Matrix Metallopeptidase 8	Protein Coding	5.7	DISEASES inferred ¹⁵
8	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.6	DISEASES inferred ¹⁵
9	PDPN	Podoplanin	Protein Coding	5.57	DISEASES inferred ¹⁵
10	PCAT19	Prostate Cancer Associated Transcript 19	RNA Gene	5.52	DISEASES inferred ¹⁵
11	SMR3A	Submaxillary Gland Androgen Regulated Protein 3A	Protein Coding	5.24	DISEASES inferred ¹⁵
12	C5orf66-AS1	C5orf66 Antisense RNA 1	RNA Gene	5.2	DISEASES inferred ¹⁵
13	ENSG00000288380		Protein Coding	5.18	DISEASES inferred ¹⁵
14	ASAP1	ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	5.14	DISEASES inferred ¹⁵
15	BCL2L12	BCL2 Like 12	Protein Coding	5.11	DISEASES inferred ¹⁵
16	SLC22A23	Solute Carrier Family 22 Member 23	Protein Coding	5.1	DISEASES inferred ¹⁵
17	CAMSAP1	Calmodulin Regulated Spectrin Associated Protein 1	Protein Coding	5.07	DISEASES inferred ¹⁵
18	CCND1	Cyclin D1	Protein Coding	5.01	DISEASES inferred ¹⁵
19	ZNF536	Zinc Finger Protein 536	Protein Coding	5.01	DISEASES inferred ¹⁵
20	MIR519B	MicroRNA 519b	RNA Gene	5.01	DISEASES inferred ¹⁵
21	RIMS2	Regulating Synaptic Membrane Exocytosis 2	Protein Coding	5	DISEASES inferred ¹⁵

Sources

Variations for Laryngeal Benign Neoplasm

Sources

Expression for Laryngeal Benign Neoplasm

Search GEO for disease gene expression data for Laryngeal Benign Neoplasm.

Sources

Pathways for Laryngeal Benign Neoplasm

Pathways related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.07	TP53 MIR106B CDKN2A CCND1
2	Proteoglycans in cancer ³⁶	11.98	TP53 MIR21 EGFR CCND1
3	MicroRNAs in cancer ³⁶	11.92	TP53 MIR21 MIR106B EGFR CDKN2A CCND1
4	Glioblastoma Multiforme ⁶³	11.6	TP53 EGFR CDKN2A CCND1
5	Bladder cancer ³⁶ ¹	11.32	TP53 EGFR CDKN2A CCND1
6	miRNAs involved in DNA damage response ¹	11.2	TP53 MIR106B CCND1
7	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.63	TP53 EGFR CDKN2A CCND1

Sources

GO Terms for Laryngeal Benign Neoplasm

Biological processes related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell migration	GO:0030335	9.62	SERPINB3 PDPN MIR21 EGFR
2	replicative senescence	GO:0090399	9.37	TP53 CDKN2A
3	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.26	TP53 EGFR
4	mitotic G1 DNA damage checkpoint	GO:0031571	9.16	TP53 CCND1
5	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.13	SERPINB3 PDPN MIR21
6	response to UV-A	GO:0070141	8.62	EGFR CCND1

Sources

Sources for Laryngeal Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia