MCID: LRY015
MIFTS: 28

Laryngeal Benign Neoplasm

Categories: Cancer diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Benign Neoplasm

MalaCards integrated aliases for Laryngeal Benign Neoplasm:

Name: Laryngeal Benign Neoplasm 12 15
Neoplasm of Larynx 12
Laryngeal Tumor 12
Larynx Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2598
MeSH 44 D007822
NCIt 50 C3156
SNOMED-CT 67 126692004
UMLS 71 C0023055

Summaries for Laryngeal Benign Neoplasm

MalaCards based summary : Laryngeal Benign Neoplasm, also known as neoplasm of larynx, is related to squamous cell papilloma and supraglottis cancer. An important gene associated with Laryngeal Benign Neoplasm is MIR106B (MicroRNA 106b), and among its related pathways/superpathways are DNA Damage Response and Proteoglycans in cancer. The drug Cisplatin has been mentioned in the context of this disorder. Related phenotype is neoplasm.

Related Diseases for Laryngeal Benign Neoplasm

Diseases related to Laryngeal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.4 TP53 CDKN2A
2 supraglottis cancer 30.3 TP53 PDPN EGFR CDKN2A
3 hypopharynx cancer 30.0 TP53 EGFR CDKN2A
4 larynx cancer 30.0 TP53 MIR21 MIR106B EGFR CDKN2A CCND1
5 papilloma 30.0 TP53 EGFR CDKN2A CCND1
6 laryngeal squamous cell carcinoma 29.9 TP53 MIR21 EGFR CDKN2A CCND1
7 laryngeal disease 29.5 TP53 PDPN MIR21 MIR106B CDKN2A CCND1
8 larynx leiomyoma 11.2
9 laryngeal neuroendocrine tumor 11.1
10 vulvar intraepithelial neoplasia 10.4 TP53 CDKN2A
11 ovarian seromucinous carcinoma 10.4 TP53 CDKN2A
12 human papillomavirus infectious disease 10.4 TP53 CDKN2A
13 malignant peritoneal mesothelioma 10.4 EGFR CDKN2A
14 spitz nevus 10.4 TP53 CDKN2A
15 orbital lymphangioma 10.4 PDPN EGFR
16 epiglottis cancer 10.4 PDPN CAGE1
17 esophageal basaloid squamous cell carcinoma 10.4 TP53 EGFR
18 papillary squamous carcinoma 10.4 EGFR CDKN2A
19 esophageal leukoplakia 10.4 TP53 CCND1
20 bizarre leiomyoma 10.3 TP53 CDKN2A
21 frontal lobe neoplasm 10.3 TP53 EGFR
22 gallbladder adenoma 10.3 PDPN CDKN2A
23 adult malignant schwannoma 10.3 TP53 CDKN2A
24 bowenoid papulosis 10.3 CDKN2A CCND1
25 pancreatic foamy gland adenocarcinoma 10.3 TP53 CCND1
26 suppressor of tumorigenicity 3 10.3 TP53 CDKN2A
27 spinal cord oligodendroglioma 10.3 TP53 EGFR
28 soft tissue sarcoma 10.3 TP53 EGFR
29 atypical neurofibroma 10.3 PDPN CDKN2A
30 localized osteosarcoma 10.3 TP53 CDKN2A
31 breast malignant phyllodes tumor 10.3 TP53 EGFR
32 xanthogranulomatous cholecystitis 10.3 TP53 PDPN
33 malignant exocrine pancreas neoplasm 10.3 TP53 CDKN2A
34 chronic cervicitis 10.3 TP53 CDKN2A
35 conjunctival squamous cell carcinoma 10.3 TP53 PDPN
36 thyroid lymphoma 10.3 TP53 CDKN2A
37 tonsil squamous cell carcinoma 10.3 CDKN2A CCND1
38 keratinizing squamous cell carcinoma 10.3 TP53 EGFR CDKN2A
39 vulva squamous cell carcinoma 10.3 TP53 EGFR CDKN2A
40 vulvar disease 10.3 TP53 EGFR CDKN2A
41 penile benign neoplasm 10.3 TP53 PDPN CDKN2A
42 peritoneum cancer 10.3 TP53 EGFR CDKN2A
43 bladder clear cell adenocarcinoma 10.3 TP53 CDKN2A
44 supratentorial cancer 10.3 TP53 EGFR CDKN2A
45 gliomatosis cerebri 10.3 TP53 EGFR CDKN2A
46 basaloid squamous cell carcinoma 10.3 TP53 EGFR CDKN2A
47 penile disease 10.3 TP53 EGFR CDKN2A
48 inverted papilloma 10.3 TP53 EGFR CDKN2A
49 lip and oral cavity cancer 10.3 TP53 EGFR CDKN2A
50 lung adenoma 10.3 TP53 EGFR CDKN2A

Graphical network of the top 20 diseases related to Laryngeal Benign Neoplasm:



Diseases related to Laryngeal Benign Neoplasm

Symptoms & Phenotypes for Laryngeal Benign Neoplasm

MGI Mouse Phenotypes related to Laryngeal Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 ASAP1 CCND1 CDKN2A EGFR PROM1 TP53

Drugs & Therapeutics for Laryngeal Benign Neoplasm

Drugs for Laryngeal Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized Clinical Trial to Compare Results of Concurrent Chemo-radiation With Surgery and Postoperative Radiotherapy/Chemoradiotherapy in Advanced Laryngeal and Hypopharyngeal Cancers Terminated NCT00128817 Phase 3
2 Clinical Evaluation of Confocal Microscopy in Head and Neck Cancer Completed NCT01626638

Search NIH Clinical Center for Laryngeal Benign Neoplasm

Genetic Tests for Laryngeal Benign Neoplasm

Anatomical Context for Laryngeal Benign Neoplasm

Publications for Laryngeal Benign Neoplasm

Articles related to Laryngeal Benign Neoplasm:

# Title Authors PMID Year
1
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. 61
27074766 2016
2
Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. 61
24968910 2014
3
Moderately differentiated neuroendocrine carcinoma of the larynx. 61
19434271 2008
4
[Influence executed of occupation on self-evaluation disorders of voice]. 61
18552035 2007
5
[Mortality of men with occupational lead poisoning in Poland]. 61
9695059 1998
6
Neoplasm of Larynx. 61
19988475 1931
7
Case of ? Neoplasm of Larynx. 61
20905449 1920
8
Case of ? Neoplasm of Larynx. 61
19981052 1920

Variations for Laryngeal Benign Neoplasm

Expression for Laryngeal Benign Neoplasm

Search GEO for disease gene expression data for Laryngeal Benign Neoplasm.

Pathways for Laryngeal Benign Neoplasm

GO Terms for Laryngeal Benign Neoplasm

Biological processes related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.26 TP53 CDKN2A
2 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.16 TP53 EGFR
3 mitotic G1 DNA damage checkpoint GO:0031571 8.96 TP53 CCND1
4 response to UV-A GO:0070141 8.62 EGFR CCND1

Molecular functions related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
2 p53 binding GO:0002039 8.8 TP53 CDKN2A BCL2L12

Sources for Laryngeal Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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