Laryngeal Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Laryngeal Benign Neoplasm

MalaCards integrated aliases for Laryngeal Benign Neoplasm:

Name: Laryngeal Benign Neoplasm ¹² ¹⁵

Neoplasm of Larynx ¹²

Laryngeal Tumor ¹²

Larynx Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2598

MeSH ⁴⁴ D007822

NCIt ⁵⁰ C3156

SNOMED-CT ⁶⁷ 126692004

UMLS ⁷¹ C0023055

Sources

Summaries for Laryngeal Benign Neoplasm

MalaCards based summary : Laryngeal Benign Neoplasm, also known as neoplasm of larynx, is related to squamous cell papilloma and supraglottis cancer. An important gene associated with Laryngeal Benign Neoplasm is MIR106B (MicroRNA 106b), and among its related pathways/superpathways are DNA Damage Response and Proteoglycans in cancer. The drug Cisplatin has been mentioned in the context of this disorder. Related phenotype is neoplasm.

Sources

Related Diseases for Laryngeal Benign Neoplasm

Diseases related to Laryngeal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)

#	Related Disease	Score	Top Affiliating Genes
1	squamous cell papilloma	30.4	TP53 CDKN2A
2	supraglottis cancer	30.3	TP53 PDPN EGFR CDKN2A
3	hypopharynx cancer	30.0	TP53 EGFR CDKN2A
4	larynx cancer	30.0	TP53 MIR21 MIR106B EGFR CDKN2A CCND1
5	papilloma	30.0	TP53 EGFR CDKN2A CCND1
6	laryngeal squamous cell carcinoma	29.9	TP53 MIR21 EGFR CDKN2A CCND1
7	laryngeal disease	29.5	TP53 PDPN MIR21 MIR106B CDKN2A CCND1
8	larynx leiomyoma	11.2
9	laryngeal neuroendocrine tumor	11.1
10	vulvar intraepithelial neoplasia	10.4	TP53 CDKN2A
11	ovarian seromucinous carcinoma	10.4	TP53 CDKN2A
12	human papillomavirus infectious disease	10.4	TP53 CDKN2A
13	malignant peritoneal mesothelioma	10.4	EGFR CDKN2A
14	spitz nevus	10.4	TP53 CDKN2A
15	orbital lymphangioma	10.4	PDPN EGFR
16	epiglottis cancer	10.4	PDPN CAGE1
17	esophageal basaloid squamous cell carcinoma	10.4	TP53 EGFR
18	papillary squamous carcinoma	10.4	EGFR CDKN2A
19	esophageal leukoplakia	10.4	TP53 CCND1
20	bizarre leiomyoma	10.3	TP53 CDKN2A
21	frontal lobe neoplasm	10.3	TP53 EGFR
22	gallbladder adenoma	10.3	PDPN CDKN2A
23	adult malignant schwannoma	10.3	TP53 CDKN2A
24	bowenoid papulosis	10.3	CDKN2A CCND1
25	pancreatic foamy gland adenocarcinoma	10.3	TP53 CCND1
26	suppressor of tumorigenicity 3	10.3	TP53 CDKN2A
27	spinal cord oligodendroglioma	10.3	TP53 EGFR
28	soft tissue sarcoma	10.3	TP53 EGFR
29	atypical neurofibroma	10.3	PDPN CDKN2A
30	localized osteosarcoma	10.3	TP53 CDKN2A
31	breast malignant phyllodes tumor	10.3	TP53 EGFR
32	xanthogranulomatous cholecystitis	10.3	TP53 PDPN
33	malignant exocrine pancreas neoplasm	10.3	TP53 CDKN2A
34	chronic cervicitis	10.3	TP53 CDKN2A
35	conjunctival squamous cell carcinoma	10.3	TP53 PDPN
36	thyroid lymphoma	10.3	TP53 CDKN2A
37	tonsil squamous cell carcinoma	10.3	CDKN2A CCND1
38	keratinizing squamous cell carcinoma	10.3	TP53 EGFR CDKN2A
39	vulva squamous cell carcinoma	10.3	TP53 EGFR CDKN2A
40	vulvar disease	10.3	TP53 EGFR CDKN2A
41	penile benign neoplasm	10.3	TP53 PDPN CDKN2A
42	peritoneum cancer	10.3	TP53 EGFR CDKN2A
43	bladder clear cell adenocarcinoma	10.3	TP53 CDKN2A
44	supratentorial cancer	10.3	TP53 EGFR CDKN2A
45	gliomatosis cerebri	10.3	TP53 EGFR CDKN2A
46	basaloid squamous cell carcinoma	10.3	TP53 EGFR CDKN2A
47	penile disease	10.3	TP53 EGFR CDKN2A
48	inverted papilloma	10.3	TP53 EGFR CDKN2A
49	lip and oral cavity cancer	10.3	TP53 EGFR CDKN2A
50	lung adenoma	10.3	TP53 EGFR CDKN2A

Graphical network of the top 20 diseases related to Laryngeal Benign Neoplasm:

Sources

Symptoms & Phenotypes for Laryngeal Benign Neoplasm

MGI Mouse Phenotypes related to Laryngeal Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.17	ASAP1 CCND1 CDKN2A EGFR PROM1 TP53

Sources

Drugs & Therapeutics for Laryngeal Benign Neoplasm

Drugs for Laryngeal Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cisplatin

Approved

Phase 3

15663-27-1

84093 441203 2767

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatin

Cisplatine

cisplatino

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase III Randomized Clinical Trial to Compare Results of Concurrent Chemo-radiation With Surgery and Postoperative Radiotherapy/Chemoradiotherapy in Advanced Laryngeal and Hypopharyngeal Cancers	Terminated	NCT00128817	Phase 3
2	Clinical Evaluation of Confocal Microscopy in Head and Neck Cancer	Completed	NCT01626638

Search NIH Clinical Center for Laryngeal Benign Neoplasm

Sources

Genetic Tests for Laryngeal Benign Neoplasm

Sources

Anatomical Context for Laryngeal Benign Neoplasm

Sources

Publications for Laryngeal Benign Neoplasm

Articles related to Laryngeal Benign Neoplasm:

#	Title	Authors	PMID	Year
1	Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ⁶¹	Novakovic D...Brotherton JM	27074766	2016
2	Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. ⁶¹	Conti S...Cernigliaro A	24968910	2014
3	Moderately differentiated neuroendocrine carcinoma of the larynx. ⁶¹	Chung EJ...Jung KY	19434271	2008
4	[Influence executed of occupation on self-evaluation disorders of voice]. ⁶¹	Ratajczak J...Jurkiewicz D	18552035	2007
5	[Mortality of men with occupational lead poisoning in Poland]. ⁶¹	Wilczynska U...Sobala W	9695059	1998
6	Neoplasm of Larynx. ⁶¹	Howarth W...Mill WA	19988475	1931
7	Case of ? Neoplasm of Larynx. ⁶¹	Mollison WM	20905449	1920
8	Case of ? Neoplasm of Larynx. ⁶¹	Mollison WM	19981052	1920

Sources

Genes for Laryngeal Benign Neoplasm

Genes related to Laryngeal Benign Neoplasm (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR106B	MicroRNA 106b	RNA Gene	7.1	DISEASES inferred ¹⁵ ¹⁵
2	MIR21	MicroRNA 21	RNA Gene	6.81	DISEASES inferred ¹⁵ ¹⁵
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.1	DISEASES inferred ¹⁵
4	CAGE1	Cancer Antigen 1	Protein Coding	5.77	DISEASES inferred ¹⁵
5	TP53	Tumor Protein P53	Protein Coding	5.73	DISEASES inferred ¹⁵
6	TREX2	Three Prime Repair Exonuclease 2	Protein Coding	5.69	DISEASES inferred ¹⁵
7	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.52	DISEASES inferred ¹⁵
8	PDPN	Podoplanin	Protein Coding	5.44	DISEASES inferred ¹⁵
9	MYHAS	Myosin Heavy Chain Gene Cluster Antisense RNA	RNA Gene	5.4	DISEASES inferred ¹⁵
10	PCAT19	Prostate Cancer Associated Transcript 19	RNA Gene	5.16	DISEASES inferred ¹⁵
11	CCND1	Cyclin D1	Protein Coding	5.09	DISEASES inferred ¹⁵
12	ASAP1	ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	5.06	DISEASES inferred ¹⁵
13	SLC22A23	Solute Carrier Family 22 Member 23	Protein Coding	5.04	DISEASES inferred ¹⁵
14	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	5.01	DISEASES inferred ¹⁵
15	PROM1	Prominin 1	Protein Coding	5	DISEASES inferred ¹⁵
16	LINC01281	Long Intergenic Non-Protein Coding RNA 1281	RNA Gene	5	DISEASES inferred ¹⁵
17	CAMSAP1	Calmodulin Regulated Spectrin Associated Protein 1	Protein Coding	5	DISEASES inferred ¹⁵
18	BCL2L12	BCL2 Like 12	Protein Coding	5	DISEASES inferred ¹⁵
19	C5orf66-AS1	C5orf66 Antisense RNA 1	RNA Gene	4.98	DISEASES inferred ¹⁵

Sources

Variations for Laryngeal Benign Neoplasm

Sources

Expression for Laryngeal Benign Neoplasm

Search GEO for disease gene expression data for Laryngeal Benign Neoplasm.

Sources

Pathways for Laryngeal Benign Neoplasm

Pathways related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.08	TP53 MIR106B CDKN2A CCND1
2	Proteoglycans in cancer ³⁶	11.98	TP53 MIR21 EGFR CCND1
3	MicroRNAs in cancer ³⁶	11.66	TP53 MIR21 MIR106B EGFR CDKN2A CCND1
4	Senescence and Autophagy in Cancer ¹	11.63	TP53 CDKN2A BMI1
5	Glioblastoma Multiforme ⁶³	11.6	TP53 EGFR CDKN2A CCND1
6	Bladder cancer ³⁶ ¹	11.32	TP53 EGFR CDKN2A CCND1
7	miRNAs involved in DNA damage response ¹	11.2	TP53 MIR106B CCND1
8	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.96	TP53 EGFR CDKN2A CCND1

Sources

GO Terms for Laryngeal Benign Neoplasm

Biological processes related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	replicative senescence	GO:0090399	9.26	TP53 CDKN2A
2	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.16	TP53 EGFR
3	mitotic G1 DNA damage checkpoint	GO:0031571	8.96	TP53 CCND1
4	response to UV-A	GO:0070141	8.62	EGFR CCND1

Molecular functions related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MDM2/MDM4 family protein binding	GO:0097371	8.96	TP53 CDKN2A
2	p53 binding	GO:0002039	8.8	TP53 CDKN2A BCL2L12

Sources

Sources for Laryngeal Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia