MCID: LRY015
MIFTS: 30

Laryngeal Benign Neoplasm

Categories: Cancer diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Benign Neoplasm

MalaCards integrated aliases for Laryngeal Benign Neoplasm:

Name: Laryngeal Benign Neoplasm 12 15
Neoplasm of Larynx 12
Laryngeal Tumor 12
Larynx Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2598
MeSH 43 D007822
NCIt 49 C3156
UMLS 71 C0023055

Summaries for Laryngeal Benign Neoplasm

MalaCards based summary : Laryngeal Benign Neoplasm, also known as neoplasm of larynx, is related to supraglottis cancer and papilloma. An important gene associated with Laryngeal Benign Neoplasm is MIR106B (MicroRNA 106b), and among its related pathways/superpathways are DNA Damage Response and Proteoglycans in cancer. Affiliated tissues include breast, lung and skin, and related phenotype is neoplasm.

Related Diseases for Laryngeal Benign Neoplasm

Diseases related to Laryngeal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 supraglottis cancer 30.5 SERPINB3 PDPN MMP8 EGFR CDKN2A
2 papilloma 30.1 TP53 EGFR CDKN2A CCND1
3 hypopharynx cancer 29.9 TP53 SERPINB3 MMP8 EGFR CDKN2A
4 laryngeal squamous cell carcinoma 29.9 TP53 MIR21 EGFR CDKN2A CCND1
5 larynx cancer 29.8 TP53 SERPINB3 MIR21 MIR106B EGFR CDKN2A
6 mucoepidermoid carcinoma 29.5 TP53 EGFR CDKN2A CCND1
7 squamous cell carcinoma 28.7 TP53 SERPINB3 PDPN EGFR CDKN2A CCND1
8 bladder cancer 28.7 TP53 MIR21 MIR106B EGFR CDKN2A CCND1
9 laryngeal disease 28.4 TP53 SERPINB3 PDPN MMP8 MIR21 MIR106B
10 larynx leiomyoma 11.4
11 laryngeal neuroendocrine tumor 11.3
12 laryngeal adenoid cystic carcinoma 10.6 SERPINB3 MMP8
13 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
14 anal carcinoma in situ 10.5 TP53 SERPINB3
15 malignant peritoneal mesothelioma 10.5 EGFR CDKN2A
16 subglottis neoplasm 10.5 SERPINB3 PDPN
17 ovarian seromucinous carcinoma 10.5 TP53 CDKN2A
18 orbital lymphangioma 10.5 PDPN EGFR
19 spitz nevus 10.5 TP53 CDKN2A
20 parotid gland cancer 10.5 TP53 SERPINB3
21 esophageal basaloid squamous cell carcinoma 10.5 TP53 EGFR
22 frontal lobe neoplasm 10.4 TP53 EGFR
23 gallbladder adenoma 10.4 PDPN CDKN2A
24 xanthogranulomatous cholecystitis 10.4 TP53 PDPN
25 soft tissue sarcoma 10.4 TP53 EGFR
26 keratinizing squamous cell carcinoma 10.4 TP53 EGFR CDKN2A
27 rectal disease 10.4 TP53 SERPINB3 CDKN2A
28 adenocarcinoma in situ 10.4 MIR21 EGFR CDKN2A
29 supraglottis neoplasm 10.4 SERPINB3 PDPN MMP8
30 papillary squamous carcinoma 10.4 EGFR CDKN2A
31 atypical neurofibroma 10.4 PDPN CDKN2A
32 vulvar disease 10.4 TP53 EGFR CDKN2A
33 peritoneum cancer 10.4 TP53 EGFR CDKN2A
34 suppressor of tumorigenicity 3 10.4 TP53 CDKN2A
35 supratentorial cancer 10.4 TP53 EGFR CDKN2A
36 gliomatosis cerebri 10.4 TP53 EGFR CDKN2A
37 basaloid squamous cell carcinoma 10.4 TP53 EGFR CDKN2A
38 epiglottis cancer 10.4 PDPN MMP8
39 fibrillary astrocytoma 10.4 TP53 EGFR CDKN2A
40 breast malignant phyllodes tumor 10.4 TP53 EGFR
41 microinvasive gastric cancer 10.4 TP53 SERPINB3 PDPN
42 luminal breast carcinoma 10.4 TP53 MIR21 EGFR
43 lung adenoma 10.4 TP53 EGFR CDKN2A
44 chronic cervicitis 10.4 TP53 CDKN2A
45 signet ring cell adenocarcinoma 10.4 TP53 SERPINB3 PDPN
46 lip cancer 10.4 TP53 PDPN MMP8
47 uterine corpus cancer 10.4 TP53 EGFR CDKN2A
48 ovarian cystadenocarcinoma 10.4 TP53 EGFR CDKN2A
49 pancreatic ductal carcinoma 10.4 TP53 EGFR CDKN2A
50 endocrine organ benign neoplasm 10.3 TP53 MIR21 MIR106B

Graphical network of the top 20 diseases related to Laryngeal Benign Neoplasm:



Diseases related to Laryngeal Benign Neoplasm

Symptoms & Phenotypes for Laryngeal Benign Neoplasm

MGI Mouse Phenotypes related to Laryngeal Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 ASAP1 CCND1 CDKN2A EGFR MMP8 TP53

Drugs & Therapeutics for Laryngeal Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quality of Life After Laser Cordectomy in Early Glottic Cancer Unknown status NCT02184403
2 Comparison of Video-Laryngoscope Versus a Combination of a Video-Laryngoscope and Disposable Bronchoscope for Predicted Difficult Airway Intubation of Anesthetized Patients for Oral Cavity, Pharynx or Larynx Surgery Recruiting NCT03080896
3 CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions Not yet recruiting NCT03214835
4 Role of Ultrasound in Diagnosis of Laryngeal Lesions Not yet recruiting NCT03450694

Search NIH Clinical Center for Laryngeal Benign Neoplasm

Genetic Tests for Laryngeal Benign Neoplasm

Anatomical Context for Laryngeal Benign Neoplasm

MalaCards organs/tissues related to Laryngeal Benign Neoplasm:

40
Breast, Lung, Skin, Tongue, Bone, Thyroid, Colon

Publications for Laryngeal Benign Neoplasm

Articles related to Laryngeal Benign Neoplasm:

# Title Authors PMID Year
1
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. 61
27074766 2016
2
Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. 61
24968910 2014
3
Moderately differentiated neuroendocrine carcinoma of the larynx. 61
19434271 2008
4
[Influence executed of occupation on self-evaluation disorders of voice]. 61
18552035 2007
5
[Mortality of men with occupational lead poisoning in Poland]. 61
9695059 1998
6
Neoplasm of Larynx. 61
19988475 1931
7
Case of ? Neoplasm of Larynx. 61
19981052 1920
8
Case of ? Neoplasm of Larynx. 61
20905449 1920

Variations for Laryngeal Benign Neoplasm

Expression for Laryngeal Benign Neoplasm

Search GEO for disease gene expression data for Laryngeal Benign Neoplasm.

Pathways for Laryngeal Benign Neoplasm

GO Terms for Laryngeal Benign Neoplasm

Biological processes related to Laryngeal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.62 SERPINB3 PDPN MIR21 EGFR
2 replicative senescence GO:0090399 9.37 TP53 CDKN2A
3 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.26 TP53 EGFR
4 mitotic G1 DNA damage checkpoint GO:0031571 9.16 TP53 CCND1
5 positive regulation of epithelial to mesenchymal transition GO:0010718 9.13 SERPINB3 PDPN MIR21
6 response to UV-A GO:0070141 8.62 EGFR CCND1

Sources for Laryngeal Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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