LC
MCID: LRY026
MIFTS: 28

Laryngeal Cleft (LC)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Name: Laryngeal Cleft 20 6
Laryngo-Tracheo-Esophageal Diastema 20
Anterior Submucous Laryngeal Cleft 20
Laryngo-Tracheo-Esophageal Cleft 20
Laryngotracheoesophageal Cleft 20
Posterior Laryngeal Cleft 20
Laryngotracheal Cleft 20
Ltec 20
Lc 20

Classifications:



Summaries for Laryngeal Cleft

GARD : 20 A laryngeal cleft is a rare malformation involving the larynx (known as the voice box) and the esophagus (known as the food pipe). Normally, when the larynx develops, it is completely separate from the esophagus so that swallowed foods travel directly through the esophagus into the stomach. A laryngeal cleft occurs when these structures do not develop normally in an embryo, and there is an opening connecting the larynx (and sometimes trachea) and the esophagus. This enables food and liquid that is swallowed to pass through the opening to the larynx, and into the lungs. Signs and symptoms may appear in the first few months of life and may include feeding problems, trouble swallowing, failure to thrive, reflux, coughing, wheezing, stridor, aspiration, respiratory distress, and recurrent lung infections. There are several different types of laryngeal clefts (types I through IV), which are classified based on the specific location and extent (severity) of the cleft. A cleft can occur as an isolated abnormality, as part of an underlying syndrome or condition (such as Opitz-Frias, VACTERL, Pallister-Hall, CHARGE ), or with other associated malformations. Treatment depends on the location and severity of the cleft and symptoms. For example, small clefts can sometimes be managed with medications to control symptoms such as reflux or aspiration, while some smaller clefts and larger clefts may need to be treated with endoscopic procedures or surgery.

MalaCards based summary : Laryngeal Cleft, also known as laryngo-tracheo-esophageal diastema, is related to laryngotracheoesophageal cleft type 0 and laryngotracheoesophageal cleft type 4. An important gene associated with Laryngeal Cleft is MID1 (Midline 1). The drug Carboxymethylcellulose Sodium has been mentioned in the context of this disorder. Affiliated tissues include trachea and tongue, and related phenotypes are laryngeal cleft and recurrent respiratory infections

Wikipedia : 73 A laryngeal cleft or laryngotracheoesophageal cleft is a rare congenital abnormality in the posterior... more...

Related Diseases for Laryngeal Cleft

Diseases related to Laryngeal Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 laryngotracheoesophageal cleft type 0 11.5
2 laryngotracheoesophageal cleft type 4 11.5
3 laryngotracheoesophageal cleft type 2 11.5
4 laryngotracheoesophageal cleft type 1 11.5
5 opitz gbbb syndrome, type ii 11.1
6 opitz-gbbb syndrome 11.0
7 dysphagia 10.4
8 tracheoesophageal fistula with or without esophageal atresia 10.3
9 isolated tracheoesophageal fistula 10.2
10 situs inversus 10.2
11 dextrocardia with situs inversus 10.2
12 esophageal malformation 10.2
13 esophageal atresia 10.2
14 diaphragmatic hernia, congenital 10.2
15 polyhydramnios 10.2
16 swallowing disorders 10.1
17 hypertelorism 10.0
18 hemifacial microsomia 10.0
19 tetralogy of fallot 10.0
20 bronchomalacia 10.0
21 pulmonary hypoplasia, primary 10.0
22 frias syndrome 10.0
23 biliary atresia 10.0
24 ventricular septal defect 10.0
25 heart septal defect 10.0
26 aspiration pneumonitis 10.0
27 double outlet right ventricle 10.0
28 eating disorder 10.0
29 craniofacial microsomia 10.0
30 pulmonary sequestration 10.0
31 cleft lip/palate 10.0
32 gastroesophageal reflux 10.0
33 anus, imperforate 10.0
34 cyanosis, transient neonatal 10.0
35 aspiration pneumonia 10.0
36 tracheobronchomalacia 10.0
37 emphysema, congenital lobar 9.9
38 pulmonary hypertension 9.9
39 48,xyyy 9.9
40 cleft palate, isolated 9.8
41 pallister-hall syndrome 9.8
42 laryngomalacia 9.8
43 feingold syndrome 1 9.8
44 charge syndrome 9.8
45 cleft larynx, posterior 9.8
46 pseudovaginal perineoscrotal hypospadias 9.8
47 opitz gbbb syndrome, type i 9.8
48 tracheobronchial stenosis, congenital 9.8
49 polydactyly 9.8
50 tracheomalacia 9.8

Graphical network of the top 20 diseases related to Laryngeal Cleft:



Diseases related to Laryngeal Cleft

Symptoms & Phenotypes for Laryngeal Cleft

Human phenotypes related to Laryngeal Cleft:

31 (show all 12)
# Description HPO Frequency HPO Source Accession
1 laryngeal cleft 31 obligate (100%) HP:0008751
2 recurrent respiratory infections 31 frequent (33%) HP:0002205
3 dyspnea 31 frequent (33%) HP:0002094
4 laryngomalacia 31 frequent (33%) HP:0001601
5 cough 31 frequent (33%) HP:0012735
6 cyanosis 31 frequent (33%) HP:0000961
7 stridor 31 frequent (33%) HP:0010307
8 hoarse cry 31 frequent (33%) HP:0001615
9 aspiration 31 frequent (33%) HP:0002835
10 choking episodes 31 frequent (33%) HP:0030842
11 impaired oropharyngeal swallow response 31 frequent (33%) HP:0031162
12 neonatal respiratory distress 31 occasional (7.5%) HP:0002643

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft Completed NCT01507207 Phase 4

Search NIH Clinical Center for Laryngeal Cleft

Genetic Tests for Laryngeal Cleft

Anatomical Context for Laryngeal Cleft

MalaCards organs/tissues related to Laryngeal Cleft:

40
Trachea, Tongue

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

(show top 50) (show all 186)
# Title Authors PMID Year
1
Laryngeal cleft: evaluation and management. 61 20
24735606 2014
2
Postoperative dysphagia immediately following pediatric endoscopic laryngeal cleft repair. 61
33454453 2021
3
Gross morphological, histological and scanning electron specifications of the oropharyngeal cavity of the hooded crow (Corvus cornix pallescens). 61
32794280 2021
4
Type 3/4 laryngeal cleft. 61
32788392 2021
5
Inter-rater reliability in diagnosis and treatment of type one laryngeal cleft: A blinded observational study. 61
33130466 2020
6
Multidisciplinary approach to paediatric aerodigestive disorders: A single-centre longitudinal observational study. 61
32886957 2020
7
Presentation and management of type 1 laryngeal clefts: A systematic review and meta-analysis. 61
33152963 2020
8
Prematurity and associated future paediatric airway pathology: experience from a single tertiary paediatric ENT centre. 61
32556789 2020
9
Fiber optic CO2-laser induced emphysema of the supraglottis. 61
32810687 2020
10
Familial and genetic factors in laryngeal cleft: Have we learned anything? 61
32771712 2020
11
A Very Rare Complication of Hyaluronic Acid Injection for Medialization Laryngoplasty: A Case With Laryngeal Abscess. 61
31005447 2020
12
Injection augmentation and endoscopic repair of type 1 laryngeal clefts: development of a management algorithm. 61
32664993 2020
13
Pediatric airway surgery under spontaneous respiration using high-flow nasal oxygen. 61
32302883 2020
14
Not Just for Kids: A Rare Case of Congenital Laryngeal Cleft in an Adult. 61
32593610 2020
15
Postoperative respiratory complications and disposition in patients with type 1 laryngeal clefts undergoing injection or repair - A single institution experience. 61
31901483 2020
16
Laryngeal cleft: Diagnosis and treatment of an unusual presentation in an adult. 61
31530375 2020
17
Genetic factors in isolated and syndromic laryngeal cleft. 61
31734186 2020
18
Pediatric flexible laryngoscopy: Trends in diagnostic abilities throughout training. 61
31707186 2020
19
Innovative management of severe tracheobronchomalacia using anterior and posterior tracheobronchopexy. 61
30908672 2020
20
Long-term swallowing outcomes following type 1 laryngeal cleft injection. 61
31648159 2020
21
Oral aspiration, type 1 laryngeal cleft, and respiratory tract infections in canadian inuit children. 61
31313533 2019
22
Pediatric dysphagia: Is interarytenoid mucosal height significant? 61
30671968 2019
23
Airway anomalies in patients with craniosynostosis. 61
30456762 2019
24
Implementing a Pediatric Perioperative Surgical Home Integrated Care Coordination Pathway for Laryngeal Cleft Repair. 61
30300182 2019
25
Flexible Fiberoptic Bronchoscopy Directed Interventions in Neonatal Intensive Care Unit. 61
31333210 2019
26
Mucocele formation following laryngeal cleft injection. 61
30450589 2019
27
Novel deletion of 6p21.31p21.1 associated with laryngeal cleft, developmental delay, dysmorphic features and vascular anomaly. 61
30142436 2019
28
A Mild Laryngeal Cleft Causes Severe Symptoms. 61
29232350 2019
29
Type 1 Laryngeal Cleft and feeding and swallowing difficulties in infants and toddlers: A Review. 61
30188606 2019
30
Standardizing Laryngeal Cleft Evaluations: Reliability of the Interarytenoid Assessment Protocol. 61
30322357 2019
31
Prevalence of voice disturbances in pediatric airway patients: Are we missing anything? 61
30583194 2019
32
A rare case of laryngeal cleft in association with VACTERL and malrotation. 61
30546815 2019
33
Evaluation of Aspiration in Infants With Laryngomalacia and Recurrent Respiratory and Feeding Difficulties. 61
30589926 2019
34
Short-term swallowing outcomes following type 1 laryngeal cleft injection. 61
30554689 2019
35
Ocular findings in a patient with oculofaciocardiodental (OFCD) syndrome and a novel BCOR pathogenic variant. 61
29058245 2018
36
Outcomes and swallowing evaluations after injection laryngoplasty for type I laryngeal cleft: Does age matter? 61
30368367 2018
37
Laryngotracheoesophageal cleft, a rare differential diagnosis of esophageal atresia. 61
30232040 2018
38
Influence of preoperative voice assessment on treatment plan prior to airway surgery. 61
30208199 2018
39
Airway Anomalies. 61
30396407 2018
40
Transoral approach to type 1 laryngeal cleft repair: A novel, non-endoscopic technique. 61
30262376 2018
41
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. 61
29673563 2018
42
Silent aspiration: Who is at risk? 61
29280496 2018
43
Airway Anomalies in Patients With 22q11.2 Deletion Syndrome: A 5-Year Review. 61
29732908 2018
44
Laryngeal cleft type IV: One pathology, two different presentations. 61
29728171 2018
45
Surface ultrastructural (SEM) characteristics of oropharyngeal cavity of house sparrow (Passer domesticus). 61
29270912 2018
46
A case of adult congenital laryngeal cleft asymptomatic until hypopharynx cancer treatment. 61
28943051 2018
47
Development and validation of a quality of life instrument for patients with laryngeal cleft. 61
29605344 2018
48
Indications for Surgical Repair of Type 1 Laryngeal Cleft. 61
29338291 2018
49
Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. 61
28910519 2018
50
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. 61
29270628 2018

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 2 genes GRCh37/hg19 7q36.3(chr7:156333296-156556779) copy number gain Uncertain significance 523286 GRCh37: 7:156333296-156556779
GRCh38:
2 overlap with 3 genes GRCh37/hg19 7q36.3(chr7:156656444-156866708) copy number gain Uncertain significance 523287 GRCh37: 7:156656444-156866708
GRCh38:

Expression for Laryngeal Cleft

Search GEO for disease gene expression data for Laryngeal Cleft.

Pathways for Laryngeal Cleft

GO Terms for Laryngeal Cleft

Sources for Laryngeal Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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