MCID: LRY026
MIFTS: 22

Laryngeal Cleft

Categories: Rare diseases

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Name: Laryngeal Cleft 54 6
Anterior Submucous Laryngeal Cleft 54
Laryngotracheoesophageal Cleft 54
Posterior Laryngeal Cleft 54
Laryngotracheal Cleft 54

Classifications:



Summaries for Laryngeal Cleft

NIH Rare Diseases : 54 A laryngeal cleft is a rare malformation involving the larynx (known as the voice box) and the esophagus (known as the food pipe). Normally, when the larynx develops, it is completely separate from the esophagus so that swallowed foods travel directly through the esophagus into the stomach. A laryngeal cleft occurs when these structures do not develop normally in an embryo, and there is an opening connecting the larynx (and sometimes trachea) and the esophagus. This enables food and liquid that is swallowed to pass through the opening to the larynx, and into the lungs. Signs and symptoms may appear in the first few months of life and may include feeding problems, trouble swallowing, failure to thrive, reflux, coughing, wheezing, stridor, aspiration, respiratory distress, and recurrent lung infections. There are several different types of laryngeal clefts (types I through IV), which are classified based on the specific location and extent (severity) of the cleft. A cleft can occur as an isolated abnormality, as part of an underlying syndrome or condition (such as Opitz-Frias, VACTERL, Pallister-Hall, CHARGE), or with other associated malformations. Treatment depends on the location and severity of the cleft and symptoms. For example, small clefts can sometimes be managed with medications to control symptoms such as reflux or aspiration, while some smaller clefts and larger clefts may need to be treated with endoscopic procedures or surgery.

MalaCards based summary : Laryngeal Cleft, also known as anterior submucous laryngeal cleft, is related to laryngotracheoesophageal cleft type 0 and laryngotracheoesophageal cleft type 4. An important gene associated with Laryngeal Cleft is MID1 (Midline 1). The drug Carboxymethylcellulose Sodium has been mentioned in the context of this disorder. Affiliated tissues include trachea and lung.

Wikipedia : 77 A laryngeal cleft or laryngotracheoesophageal cleft is a rare congenital abnormality in the posterior... more...

Related Diseases for Laryngeal Cleft

Graphical network of the top 20 diseases related to Laryngeal Cleft:



Diseases related to Laryngeal Cleft

Symptoms & Phenotypes for Laryngeal Cleft

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft Completed NCT01507207 Phase 4
2 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881

Search NIH Clinical Center for Laryngeal Cleft

Genetic Tests for Laryngeal Cleft

Anatomical Context for Laryngeal Cleft

MalaCards organs/tissues related to Laryngeal Cleft:

42
Trachea, Lung

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

(show top 50) (show all 81)
# Title Authors Year
1
A Mild Laryngeal Cleft Causes Severe Symptoms. ( 29232350 )
2019
2
Type 1 Laryngeal Cleft and feeding and swallowing difficulties in infants and toddlers: A Review. ( 30188606 )
2019
3
Standardizing Laryngeal Cleft Evaluations: Reliability of the Interarytenoid Assessment Protocol. ( 30322357 )
2019
4
A rare case of laryngeal cleft in association with VACTERL and malrotation. ( 30546815 )
2019
5
Short-term swallowing outcomes following type 1 laryngeal cleft injection. ( 30554689 )
2019
6
Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )
2018
7
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )
2018
8
A case of adult congenital laryngeal cleft asymptomatic until hypopharynx cancer treatment. ( 28943051 )
2018
9
Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. ( 28910519 )
2018
10
Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )
2018
11
Development and validation of a quality of life instrument for patients with laryngeal cleft. ( 29605344 )
2018
12
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. ( 29673563 )
2018
13
Laryngeal cleft type IV: One pathology, two different presentations. ( 29728171 )
2018
14
Novel deletion of 6p21.31p21.1 associated with laryngeal cleft, developmental delay, dysmorphic features and vascular anomaly. ( 30142436 )
2018
15
Transoral approach to type 1 laryngeal cleft repair: A novel, non-endoscopic technique. ( 30262376 )
2018
16
Implementing a Pediatric Perioperative Surgical Home Integrated Care Coordination Pathway for Laryngeal Cleft Repair. ( 30300182 )
2018
17
Outcomes and swallowing evaluations after injection laryngoplasty for type I laryngeal cleft: Does age matter? ( 30368367 )
2018
18
Mucocele formation following laryngeal cleft injection. ( 30450589 )
2018
19
Images in Anesthesiology: Laryngeal Cleft. ( 28098610 )
2017
20
Neurologic Evaluation in Children With Laryngeal Cleft. ( 28384788 )
2017
21
Assessment of the feeding Swallowing Impact Survey as a quality of life measure in children with laryngeal cleft before and after repair. ( 28688569 )
2017
22
Radiation exposure from videofluoroscopic swallow studies in children with a type 1 laryngeal cleft and pharyngeal dysphagia: A retrospective review. ( 27619036 )
2016
23
Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration? ( 26857313 )
2016
24
Outcomes and predictors of surgical management in type 1 laryngeal cleft swallowing dysfunction. ( 27172174 )
2016
25
Modified Best-Practice Algorithm to Reduce the Number of Postoperative Videofluoroscopic Swallow Studies in Patients With Type 1 Laryngeal Cleft Repair. ( 27356238 )
2016
26
Early surgical intervention in type I laryngeal cleft. ( 27729141 )
2016
27
Laryngeal cleft: Diagnosis and endoscopic surgical treatment. Report of 2 cases. ( 24930855 )
2015
28
The association between laryngeal cleft and tracheoesophageal fistula: myth or reality? ( 24964996 )
2015
29
Postoperative observation of children after endoscopic type 1 posterior laryngeal cleft repair. ( 25378373 )
2015
30
Low inter-arytenoid height: a subclassification of type 1 laryngeal cleft diagnosis and management. ( 25481333 )
2015
31
Delayed presentation of a large congenital laryngeal cleft in an adult. ( 25519258 )
2015
32
The varying presentations of type I laryngeal cleft: illustrative cases in a set of triplets. ( 25661006 )
2015
33
Type I-II laryngeal cleft: clinical course and outcome. ( 26040049 )
2015
34
[Type III laryngeal cleft in an infant]. ( 24060360 )
2015
35
Type 1 laryngeal cleft: a multidimensional management algorithm. ( 24263209 )
2014
36
Transoral robotic-assisted laryngeal cleft repair in the pediatric patient. ( 24648210 )
2014
37
Laryngeal cleft: evaluation and management. ( 24735606 )
2014
38
Swallowing function after laryngeal cleft repair: more than just fixing the cleft. ( 25098751 )
2014
39
Laryngeal cleft type I in neonate: case report. ( 25388077 )
2014
40
Surgical management of type I and II laryngeal cleft in the pediatric population. ( 25465448 )
2014
41
Adult presentation of laryngeal cleft: Utility of the modified barium swallow study in diagnosis and management. ( 25531847 )
2014
42
Minimally invasive approach to laryngeal cleft. ( 22865688 )
2013
43
Repair of long type IV posterior laryngeal cleft through a cervical approach using cricotracheal separation. ( 23297095 )
2013
44
Laryngeal cleft repair: the anesthetic perspective. ( 23368883 )
2013
45
An unusual case of anterior and posterior laryngeal cleft together: combined cleft of larynx. ( 21968633 )
2012
46
Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. ( 22302106 )
2012
47
Laryngeal cleft. ( 22472237 )
2012
48
Injection laryngoplasty for type 1 laryngeal cleft in children. ( 21493369 )
2011
49
Chest radiographic and CT evaluation of lung abnormalities in pediatric patients with laryngeal cleft. ( 21618719 )
2011
50
Exomphalos and type IV laryngeal cleft: a surgical challenge. ( 19212936 )
2009

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LMBR1; RNF32 GRCh37/hg19 7q36.3(chr7: 156333296-156556779) copy number gain Uncertain significance GRCh37 Chromosome 7, 156333296: 156556779
2 LMBR1; MNX1; NOM1 GRCh37/hg19 7q36.3(chr7: 156656444-156866708) copy number gain Uncertain significance GRCh37 Chromosome 7, 156656444: 156866708

Expression for Laryngeal Cleft

Search GEO for disease gene expression data for Laryngeal Cleft.

Pathways for Laryngeal Cleft

GO Terms for Laryngeal Cleft

Sources for Laryngeal Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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