MCID: LRY026
MIFTS: 26

Laryngeal Cleft

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Name: Laryngeal Cleft 53 29 6
Anterior Submucous Laryngeal Cleft 53
Congenital Laryngeal Clefts 53
Posterior Laryngeal Cleft 53
Cleft, Larynx Posterior 53
Type 1a 53

Classifications:



Summaries for Laryngeal Cleft

NIH Rare Diseases : 53 A laryngeal cleft is a rare abnormality of the separation between the larynx, or voice box, and the esophagus. Normally, when the larynx develops, it is completely separate from the esophagus so swallowed foods go directly into the stomach. When a laryngeal cleft occurs, there is an opening between the larynx and the esophagus so food and liquid can pass through the larynx into the lungs. There are several different types of laryngeal clefts (Types I through IV), classified based on the extent of the clefting.

MalaCards based summary : Laryngeal Cleft, also known as anterior submucous laryngeal cleft, is related to muscular dystrophy, limb-girdle, type 1a and charcot-marie-tooth disease, demyelinating, type 1a. An important gene associated with Laryngeal Cleft is MID1 (Midline 1). The drug Carboxymethylcellulose Sodium has been mentioned in the context of this disorder. Affiliated tissues include lung and trachea.

Wikipedia : 76 A laryngeal cleft or laryngotracheoesophageal cleft is a rare congenital abnormality in the posterior... more...

Related Diseases for Laryngeal Cleft

Diseases related to Laryngeal Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 muscular dystrophy, limb-girdle, type 1a 12.4
2 charcot-marie-tooth disease, demyelinating, type 1a 12.3
3 congenital muscular dystrophy type 1a 12.2
4 cleft larynx, posterior 12.2
5 night blindness, congenital stationary, type 1a 12.2
6 vitamin d hydroxylation-deficient rickets, type 1a 12.1
7 pontocerebellar hypoplasia, type 1a 12.0
8 arthrogryposis, distal, type 1a 11.9
9 glaucoma, hereditary adult type 1a 11.8
10 glycogen storage disease ia 11.7
11 achondrogenesis, type ia 11.6
12 albright's hereditary osteodystrophy 11.5
13 albinism, oculocutaneous, type ia 11.5
14 pseudohypoparathyroidism, type ia 11.4
15 facioscapulohumeral muscular dystrophy 1 11.4
16 achondrogenesis 11.3
17 novak syndrome 11.2
18 rickets 11.2
19 pseudopseudohypoparathyroidism 11.1
20 schwartz-jampel syndrome, type 1 11.1
21 neuropathy, hereditary sensory and autonomic, type ia 11.1
22 zygodactyly 1 11.1
23 progressive familial heart block, type ia 11.1
24 maple syrup urine disease 11.1
25 congenital disorder of glycosylation, type ia 11.0
26 achondrogenesis, type ii 11.0
27 achondrogenesis, type ib 11.0
28 autoimmune lymphoproliferative syndrome 10.9
29 syngnathia 10.8
30 hyperlipoproteinemia, type v 10.8
31 roussy-levy hereditary areflexic dystasia 10.8
32 vitamin d-dependent rickets, type 2a 10.8
33 vitamin d-dependent rickets, type 2b, with normal vitamin d receptor 10.8
34 pseudohypoparathyroidism, type ic 10.8
35 yuan-harel-lupski syndrome 10.8
36 amelogenesis imperfecta, type ia 10.8
37 cardiomyopathy, dilated, 1a 10.8
38 glaucoma 1, open angle, a 10.8
39 palmoplantar keratoderma, punctate type ia 10.8
40 peroxisome biogenesis disorder 1a 10.8
41 deafness, autosomal recessive 1a 10.8
42 hyperlipoproteinemia, type i 10.8
43 myasthenic syndrome, congenital, 6, presynaptic 10.8
44 myoclonic epilepsy of unverricht and lundborg 10.8
45 isolated growth hormone deficiency, type ia 10.8
46 usher syndrome, type i 10.8
47 myasthenic syndrome, congenital, 1a, slow-channel 10.8
48 muscular dystrophy, congenital merosin-deficient, 1a 10.8
49 congenital disorder of glycosylation, type ie 10.8
50 lama2-related muscular dystrophy 10.8

Graphical network of the top 20 diseases related to Laryngeal Cleft:



Diseases related to Laryngeal Cleft

Symptoms & Phenotypes for Laryngeal Cleft

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft Completed NCT01507207 Phase 4
2 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881

Search NIH Clinical Center for Laryngeal Cleft

Genetic Tests for Laryngeal Cleft

Genetic tests related to Laryngeal Cleft:

# Genetic test Affiliating Genes
1 Laryngeal Cleft 29

Anatomical Context for Laryngeal Cleft

MalaCards organs/tissues related to Laryngeal Cleft:

41
Lung, Trachea

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

(show top 50) (show all 75)
# Title Authors Year
1
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. ( 29673563 )
2018
2
Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )
2018
3
Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )
2018
4
Laryngeal cleft type IV: One pathology, two different presentations. ( 29728171 )
2018
5
Development and validation of a quality of life instrument for patients with laryngeal cleft. ( 29605344 )
2018
6
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )
2018
7
[Pediatric laryngeal clefts: an experience in the diagnosis and management of 13 cases]. ( 28910893 )
2017
8
Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. ( 28910519 )
2017
9
Assessment of the feeding Swallowing Impact Survey as a quality of life measure in children with laryngeal cleft before and after repair. ( 28688569 )
2017
10
Neurologic Evaluation in Children With Laryngeal Cleft. ( 28384788 )
2017
11
A case of adult congenital laryngeal cleft asymptomatic until hypopharynx cancer treatment. ( 28943051 )
2017
12
A Mild Laryngeal Cleft Causes Severe Symptoms. ( 29232350 )
2017
13
Images in Anesthesiology: Laryngeal Cleft. ( 28098610 )
2017
14
Radiation exposure from videofluoroscopic swallow studies in children with a type 1 laryngeal cleft and pharyngeal dysphagia: A retrospective review. ( 27619036 )
2016
15
Outcomes and predictors of surgical management in type 1 laryngeal cleft swallowing dysfunction. ( 27172174 )
2016
16
Laryngeal Cleft. ( 27575446 )
2016
17
Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration? ( 26857313 )
2016
18
Modified Best-Practice Algorithm to Reduce the Number of Postoperative Videofluoroscopic Swallow Studies in Patients With Type 1 Laryngeal Cleft Repair. ( 27356238 )
2016
19
Early surgical intervention in type I laryngeal cleft. ( 27729141 )
2016
20
The varying presentations of type I laryngeal cleft: illustrative cases in a set of triplets. ( 25661006 )
2015
21
Delayed presentation of a large congenital laryngeal cleft in an adult. ( 25519258 )
2015
22
Low inter-arytenoid height: a subclassification of type 1 laryngeal cleft diagnosis and management. ( 25481333 )
2015
23
Type I-II laryngeal cleft: clinical course and outcome. ( 26040049 )
2015
24
Laryngeal cleft: evaluation and management. ( 24735606 )
2014
25
Swallowing function after laryngeal cleft repair: more than just fixing the cleft. ( 25098751 )
2014
26
Type 1 laryngeal cleft: a multidimensional management algorithm. ( 24263209 )
2014
27
Adult presentation of laryngeal cleft: Utility of the modified barium swallow study in diagnosis and management. ( 25531847 )
2014
28
Laryngeal cleft type I in neonate: case report. ( 25388077 )
2014
29
Surgical management of type I and II laryngeal cleft in the pediatric population. ( 25465448 )
2014
30
Transoral robotic-assisted laryngeal cleft repair in the pediatric patient. ( 24648210 )
2014
31
Postoperative Observation of Children after Endoscopic Type 1 Posterior Laryngeal Cleft Repair. ( 25378373 )
2014
32
Laryngeal cleft: Diagnosis and endoscopic surgical treatment. Report of 2 cases. ( 24930855 )
2014
33
The association between laryngeal cleft and tracheoesophageal fistula: Myth or reality? ( 24964996 )
2014
34
Minimally invasive approach to laryngeal cleft. ( 22865688 )
2013
35
Type III laryngeal cleft in an infant. ( 24060360 )
2013
36
Repair of long type IV posterior laryngeal cleft through a cervical approach using cricotracheal separation. ( 23297095 )
2013
37
Laryngeal cleft repair: the anesthetic perspective. ( 23368883 )
2013
38
Injection augmentation of type I laryngeal clefts. ( 22261489 )
2012
39
Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. ( 22302106 )
2012
40
An unusual case of anterior and posterior laryngeal cleft together: combined cleft of larynx. ( 21968633 )
2012
41
Laryngeal cleft. ( 22472237 )
2012
42
Injection laryngoplasty for type 1 laryngeal cleft in children. ( 21493369 )
2011
43
Chest radiographic and CT evaluation of lung abnormalities in pediatric patients with laryngeal cleft. ( 21618719 )
2011
44
Exomphalos and type IV laryngeal cleft: a surgical challenge. ( 19212936 )
2009
45
Endoscopic repair of laryngeal cleft type I and type II: when and why? ( 19554639 )
2009
46
Left tracheal bronchus in an infant with laryngeal cleft. ( 23168471 )
2009
47
Control of salivary secretions in esophageal atresia with laryngeal cleft using Botulinum toxin Type A. ( 18479756 )
2008
48
Laryngeal cleft. ( 18775342 )
2008
49
The presentation and management of laryngeal cleft: a 10-year experience. ( 17178945 )
2006
50
Type 1 laryngeal cleft: establishing a functional diagnostic and management algorithm. ( 16959329 )
2006

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LMBR1; RNF32 GRCh37/hg19 7q36.3(chr7: 156333296-156556779) copy number gain Uncertain significance GRCh37 Chromosome 7, 156333296: 156556779
2 LMBR1; MNX1; NOM1 GRCh37/hg19 7q36.3(chr7: 156656444-156866708) copy number gain Uncertain significance GRCh37 Chromosome 7, 156656444: 156866708

Expression for Laryngeal Cleft

Search GEO for disease gene expression data for Laryngeal Cleft.

Pathways for Laryngeal Cleft

GO Terms for Laryngeal Cleft

Sources for Laryngeal Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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