MCID: LRY026
MIFTS: 25

Laryngeal Cleft

Categories: Rare diseases

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Name: Laryngeal Cleft 53 29 6
Anterior Submucous Laryngeal Cleft 53
Laryngotracheoesophageal Cleft 53
Posterior Laryngeal Cleft 53
Laryngotracheal Cleft 53

Classifications:



Summaries for Laryngeal Cleft

NIH Rare Diseases : 53 A laryngeal cleft is a rare malformation involving the larynx (known as the voice box) and the esophagus (known as the food pipe). Normally, when the larynx develops, it is completely separate from the esophagus so that swallowed foods travel directly through the esophagus into the stomach. A laryngeal cleft occurs when these structures do not develop normally in an embryo, and there is an opening connecting the larynx (and sometimes trachea) and the esophagus. This enables food and liquid that is swallowed to pass through the opening to the larynx, and into the lungs. Signs and symptoms may appear in the first few months of life and may include feeding problems, trouble swallowing, failure to thrive, reflux, coughing, wheezing, stridor, aspiration, respiratory distress, and recurrent lung infections. There are several different types of laryngeal clefts (types I through IV), which are classified based on the specific location and extent (severity) of the cleft. A cleft can occur as an isolated abnormality, as part of an underlying syndrome or condition (such as Opitz-Frias, VACTERL, Pallister-Hall, CHARGE), or with other associated malformations. Treatment depends on the location and severity of the cleft and symptoms. For example, small clefts can sometimes be managed with medications to control symptoms such as reflux or aspiration, while some smaller clefts and larger clefts may need to be treated with endoscopic procedures or surgery.

MalaCards based summary : Laryngeal Cleft, also known as anterior submucous laryngeal cleft, is related to laryngotracheoesophageal cleft type 0 and laryngotracheoesophageal cleft type 4. An important gene associated with Laryngeal Cleft is MID1 (Midline 1). The drug Carboxymethylcellulose Sodium has been mentioned in the context of this disorder. Affiliated tissues include trachea and lung.

Wikipedia : 76 A laryngeal cleft or laryngotracheoesophageal cleft is a rare congenital abnormality in the posterior... more...

Related Diseases for Laryngeal Cleft

Graphical network of the top 20 diseases related to Laryngeal Cleft:



Diseases related to Laryngeal Cleft

Symptoms & Phenotypes for Laryngeal Cleft

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft Completed NCT01507207 Phase 4
2 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881

Search NIH Clinical Center for Laryngeal Cleft

Genetic Tests for Laryngeal Cleft

Genetic tests related to Laryngeal Cleft:

# Genetic test Affiliating Genes
1 Laryngeal Cleft 29

Anatomical Context for Laryngeal Cleft

MalaCards organs/tissues related to Laryngeal Cleft:

41
Trachea, Lung

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

(show top 50) (show all 82)
# Title Authors Year
1
A rare case of laryngeal cleft in association with VACTERL and malrotation. ( 30546815 )
2019
2
Short-term swallowing outcomes following type 1 laryngeal cleft injection. ( 30554689 )
2019
3
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. ( 29673563 )
2018
4
Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )
2018
5
Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )
2018
6
Laryngeal cleft type IV: One pathology, two different presentations. ( 29728171 )
2018
7
Development and validation of a quality of life instrument for patients with laryngeal cleft. ( 29605344 )
2018
8
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )
2018
9
Novel deletion of 6p21.31p21.1 associated with laryngeal cleft, developmental delay, dysmorphic features and vascular anomaly. ( 30142436 )
2018
10
Type 1 Laryngeal Cleft and feeding and swallowing difficulties in infants and toddlers: A Review. ( 30188606 )
2018
11
Transoral approach to type 1 laryngeal cleft repair: A novel, non-endoscopic technique. ( 30262376 )
2018
12
Implementing a Pediatric Perioperative Surgical Home Integrated Care Coordination Pathway for Laryngeal Cleft Repair. ( 30300182 )
2018
13
Standardizing Laryngeal Cleft Evaluations: Reliability of the Interarytenoid Assessment Protocol. ( 30322357 )
2018
14
Outcomes and swallowing evaluations after injection laryngoplasty for type I laryngeal cleft: Does age matter? ( 30368367 )
2018
15
Mucocele formation following laryngeal cleft injection. ( 30450589 )
2018
16
Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. ( 28910519 )
2017
17
Assessment of the feeding Swallowing Impact Survey as a quality of life measure in children with laryngeal cleft before and after repair. ( 28688569 )
2017
18
Neurologic Evaluation in Children With Laryngeal Cleft. ( 28384788 )
2017
19
A case of adult congenital laryngeal cleft asymptomatic until hypopharynx cancer treatment. ( 28943051 )
2017
20
A Mild Laryngeal Cleft Causes Severe Symptoms. ( 29232350 )
2017
21
Images in Anesthesiology: Laryngeal Cleft. ( 28098610 )
2017
22
Radiation exposure from videofluoroscopic swallow studies in children with a type 1 laryngeal cleft and pharyngeal dysphagia: A retrospective review. ( 27619036 )
2016
23
Outcomes and predictors of surgical management in type 1 laryngeal cleft swallowing dysfunction. ( 27172174 )
2016
24
Laryngeal Cleft. ( 27575446 )
2016
25
Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration? ( 26857313 )
2016
26
Modified Best-Practice Algorithm to Reduce the Number of Postoperative Videofluoroscopic Swallow Studies in Patients With Type 1 Laryngeal Cleft Repair. ( 27356238 )
2016
27
Early surgical intervention in type I laryngeal cleft. ( 27729141 )
2016
28
The varying presentations of type I laryngeal cleft: illustrative cases in a set of triplets. ( 25661006 )
2015
29
Delayed presentation of a large congenital laryngeal cleft in an adult. ( 25519258 )
2015
30
Low inter-arytenoid height: a subclassification of type 1 laryngeal cleft diagnosis and management. ( 25481333 )
2015
31
Type I-II laryngeal cleft: clinical course and outcome. ( 26040049 )
2015
32
Laryngeal cleft: evaluation and management. ( 24735606 )
2014
33
Swallowing function after laryngeal cleft repair: more than just fixing the cleft. ( 25098751 )
2014
34
Type 1 laryngeal cleft: a multidimensional management algorithm. ( 24263209 )
2014
35
Adult presentation of laryngeal cleft: Utility of the modified barium swallow study in diagnosis and management. ( 25531847 )
2014
36
Laryngeal cleft type I in neonate: case report. ( 25388077 )
2014
37
Surgical management of type I and II laryngeal cleft in the pediatric population. ( 25465448 )
2014
38
Transoral robotic-assisted laryngeal cleft repair in the pediatric patient. ( 24648210 )
2014
39
Postoperative Observation of Children after Endoscopic Type 1 Posterior Laryngeal Cleft Repair. ( 25378373 )
2014
40
Laryngeal cleft: Diagnosis and endoscopic surgical treatment. Report of 2 cases. ( 24930855 )
2014
41
The association between laryngeal cleft and tracheoesophageal fistula: Myth or reality? ( 24964996 )
2014
42
Minimally invasive approach to laryngeal cleft. ( 22865688 )
2013
43
Type III laryngeal cleft in an infant. ( 24060360 )
2013
44
Repair of long type IV posterior laryngeal cleft through a cervical approach using cricotracheal separation. ( 23297095 )
2013
45
Laryngeal cleft repair: the anesthetic perspective. ( 23368883 )
2013
46
An unusual case of anterior and posterior laryngeal cleft together: combined cleft of larynx. ( 21968633 )
2012
47
Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. ( 22302106 )
2012
48
Laryngeal cleft. ( 22472237 )
2012
49
Injection laryngoplasty for type 1 laryngeal cleft in children. ( 21493369 )
2011
50
Chest radiographic and CT evaluation of lung abnormalities in pediatric patients with laryngeal cleft. ( 21618719 )
2011

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LMBR1; RNF32 GRCh37/hg19 7q36.3(chr7: 156333296-156556779) copy number gain Uncertain significance GRCh37 Chromosome 7, 156333296: 156556779
2 LMBR1; MNX1; NOM1 GRCh37/hg19 7q36.3(chr7: 156656444-156866708) copy number gain Uncertain significance GRCh37 Chromosome 7, 156656444: 156866708

Expression for Laryngeal Cleft

Search GEO for disease gene expression data for Laryngeal Cleft.

Pathways for Laryngeal Cleft

GO Terms for Laryngeal Cleft

Sources for Laryngeal Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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