Laryngeal Cleft disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Name: Laryngeal Cleft ¹⁹ ⁷⁵ ⁵

Laryngo-Tracheo-Esophageal Diastema ¹⁹ ⁵⁸

Laryngo-Tracheo-Esophageal Cleft ¹⁹ ⁵⁸

Laryngotracheoesophageal Cleft ¹⁹ ⁵⁸

Ltec ¹⁹ ⁵⁸

Lc ¹⁹ ⁵⁸

Anterior Submucous Laryngeal Cleft ¹⁹

Posterior Laryngeal Cleft ¹⁹

Laryngotracheal Cleft ¹⁹

Characteristics:

Inheritance:

Laryngotracheoesophageal Cleft: Autosomal dominant ⁵⁸

Prevelance:

Laryngotracheoesophageal Cleft: 1-9/100000 (Europe) ⁵⁸

Age Of Onset:

Laryngotracheoesophageal Cleft: Antenatal,Neonatal ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Oral diseases Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the respiratory system

Congenital malformations of trachea and bronchus

Other congenital malformations of trachea

Orphanet: ⁵⁸

Rare otorhinolaryngological diseases

Rare respiratory diseases

Developmental anomalies during embryogenesis

External Ids:

ICD10 via Orphanet ³² Q32.1

Orphanet ⁵⁸ ORPHA2004

SNOMED-CT via HPO ⁶⁹ 119419001 230145002 232461002 more

Sources

Summaries for Laryngeal Cleft

GARD: ¹⁹ A Laryngeal cleft is a rare malformation involving the larynx (known as the voice box) and the esophagus (known as the food pipe). Normally, when the larynx develops, it is completely separate from the esophagus so that swallowed foods travel directly through the esophagus into the stomach. A Laryngeal cleft occurs when these structures do not develop normally in an embryo, and there is an opening connecting the larynx (and sometimes trachea) and the esophagus. This enables food and liquid that is swallowed to pass through the opening to the larynx, and into the lungs. Signs and symptoms may appear in the first few months of life and may include feeding problems, trouble swallowing, failure to thrive, reflux, coughing, wheezing, stridor, aspiration, respiratory distress, and recurrent lung infections. There are several different types of Laryngeal clefts (types I through IV), which are classified based on the specific location and extent (severity) of the cleft. A cleft can occur as an isolated abnormality, as part of an underlying syndrome or condition (such as Opitz-Frias, VACTERL, Pallister-Hall, CHARGE), or with other associated malformations.

MalaCards based summary: Laryngeal Cleft, also known as laryngo-tracheo-esophageal diastema, is related to laryngotracheoesophageal cleft type 0 and opitz gbbb syndrome. An important gene associated with Laryngeal Cleft is MID1 (Midline 1). The drug Carboxymethylcellulose Sodium has been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and lymph node, and related phenotypes are laryngeal cleft and recurrent respiratory infections

Orphanet: ⁵⁸ A laryngo-tracheo-esophageal cleft (LC) is a congenital malformation characterized by an abnormal, posterior, sagittal communication between the larynx and the pharynx, possibly extending downward between the trachea and the esophagus.

Wikipedia: ⁷⁵ A laryngeal cleft or laryngotracheoesophageal cleft is a rare congenital abnormality in the posterior... more...

Sources

Related Diseases for Laryngeal Cleft

Diseases related to Laryngeal Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Related Disease	Score
1	laryngotracheoesophageal cleft type 0	11.8
2	opitz gbbb syndrome	11.1
3	laryngotracheoesophageal cleft type 4	11.0
4	laryngotracheoesophageal cleft type 2	11.0
5	laryngotracheoesophageal cleft type 1	11.0
6	esophageal atresia	10.4
7	isolated tracheoesophageal fistula	10.3
8	situs inversus	10.2
9	dextrocardia with situs inversus	10.2
10	esophageal malformation	10.2
11	diaphragmatic hernia, congenital	10.2
12	pulmonary hypoplasia, primary	10.2
13	enterocele	10.2
14	double outlet right ventricle	10.2
15	polyhydramnios	10.2
16	swallowing disorders	10.1
17	gastroesophageal reflux	10.1
18	teebi hypertelorism syndrome 1	10.1
19	hypertelorism	10.0
20	tetralogy of fallot	10.0
21	williams-campbell syndrome	10.0
22	conotruncal heart malformations	10.0
23	cystic fibrosis	10.0
24	transposition of the great arteries, dextro-looped	10.0
25	frias syndrome	10.0
26	bronchopneumonia	10.0
27	biliary atresia	10.0
28	ventricular septal defect	10.0
29	heart septal defect	10.0
30	aspiration pneumonitis	10.0
31	pulmonary sequestration	10.0
32	cleft lip/palate	10.0
33	vater/vacterl association	10.0
34	anus, imperforate	10.0
35	aspiration pneumonia	10.0
36	respiratory failure	10.0
37	tracheobronchomalacia	10.0
38	craniofacial microsomia	10.0
39	eating disorder	10.0
40	emphysema, congenital lobar	9.9
41	pulmonary hypertension	9.9
42	48,xyyy	9.9
43	cleft palate, isolated	9.8
44	coarctation of aorta	9.8
45	pallister-hall syndrome	9.8
46	laryngomalacia	9.8
47	feingold syndrome 1	9.8
48	polydactyly, postaxial, type a1	9.8
49	renal hypodysplasia/aplasia 1	9.8
50	charge syndrome	9.8

Graphical network of the top 20 diseases related to Laryngeal Cleft:

Sources

Symptoms & Phenotypes for Laryngeal Cleft

Human phenotypes related to Laryngeal Cleft:

⁵⁸ ³⁰ (show all 13)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	laryngeal cleft ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0008751
2	recurrent respiratory infections ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002205
3	dyspnea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002094
4	laryngomalacia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001601
5	cough ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012735
6	cyanosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000961
7	stridor ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010307
8	hoarse cry ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001615
9	aspiration ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002835
10	choking episodes ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030842
11	impaired oropharyngeal swallow response ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031162
12	neonatal respiratory distress ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002643
13	abnormality of the voice ⁵⁸		Frequent (79-30%)

Sources

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Carboxymethylcellulose Sodium		Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft	Completed	NCT01507207	Phase 4
2	Comprehensive Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients	Recruiting	NCT03455881

Search NIH Clinical Center for Laryngeal Cleft

Sources

Genetic Tests for Laryngeal Cleft

Sources

Anatomical Context for Laryngeal Cleft

Organs/tissues related to Laryngeal Cleft:

MalaCards : Trachea, Lung, Lymph Node, Tongue

Sources

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

(show top 50) (show all 351)

#	Title	Authors	PMID	Year
1	Pediatric laryngeal cleft repair with coblation: Functional comparison of a novel technique with traditional methods. ⁶²	Shah HP...Valika T	36371939	2022
2	Spectrum of swallowing abnormalities in children with Type I laryngeal cleft. ⁶²	Liao K...Ulualp SO	36379096	2022
3	Management of Symptomatic Grade I and II Laryngeal Cleft: Experience of a Tertiary Care Center and Review of Literature. ⁶²	Nayak A...Vinusree K	36452777	2022
4	Transfixing Anterior Laryngeal Cleft in a Malformed Stillborn at Term: Case Report. ⁶²	Veronica MC...Jorge A FZ	36190915	2022
5	Endoscopic Repair of Laryngeal Clefts: 8 Years' Experience. ⁶²	Emmanuel R...Shivnani D	36213473	2022
6	Endoscopic Posterior Costochondral Graft with Cricoid Sutures for a Recurrent Type 3 Laryngeal Cleft. ⁶²	Richardson C...Johnson K	36149911	2022
7	Type-1 Laryngeal Cleft and Pathogenic Bacterial Growth in the Lower Airway in Children. ⁶²	Ha TN...Das S	35084780	2022
8	Early detection of laryngeal cleft in infants by novel technique of flexible endoscopy with sustained pharyngeal inflation. ⁶²	Soong WJ...Soong YH	35596199	2022
9	Beyond Laryngeal Clefts: Interarytenoid Injection Augmentation to Predict Success of Suture Augmentation in Children. ⁶²	Jauregui EJ...Johnson K	36069277	2022
10	A Validated 3D Printed Laryngeal Suturing Simulator for Endoscopic Laryngeal Cleft Repair. ⁶²	Richardson CM...Johnson KE	35932231	2022
11	Combined laryngeal cleft injection laryngoplasty and salivary botulinum toxin for saliva aspiration. ⁶²	Nguyen J...Lambert EM	36000049	2022
12	Postoperative respiratory adverse events in children after endoscopic laryngeal cleft repair. ⁶²	Yalamanchili R...Hochstim C	35024957	2022
13	Type 2 laryngeal cleft associated with OpitzG/BBB syndrome. ⁶²	Garcia-Muro C...Navazo-Eguia A	35577436	2022
14	The changing face of paediatric airway endoscopic surgery: An 8-year single surgeon review. ⁶²	Zubair A...Bajaj Y	35334239	2022
15	Surgical Treatment of Type III Laryngotracheoesophageal Clefts: Techniques and Outcomes. ⁶²	Kou YF...de Alarcon A	34533209	2022
16	Does the History of Tracheoesophageal Fistula Repair Alter Outcomes of Laryngeal Cleft Repair? ⁶²	Nebor I...de Alarcon A	35536656	2022
17	A multi-disciplinary approach to chronic cough in children. ⁶²	Mukerji SS...Bedwell JR	35434349	2022
18	Neuroimaging appearance of hypothalamic hamartomas in monozygotic twins with Pallister-Hall syndrome: case report and review of the literature. ⁶²	Consales A...Fumagalli M	35331151	2022
19	Not Just for Kids: A Rare Case of Congenital Laryngeal Cleft in an Adult. ⁶²	Xiao CC...Jiang N	32593610	2022
20	Injection laryngoplasty for laryngeal cleft type I in an 8-week-old infant. ⁶²	van Stigt MJB...Bittermann AJN	35236684	2022
21	Multidisciplinary management of a neonate in respiratory distress with undiagnosed type IV laryngeal cleft. ⁶²	Chang DR...Barnett N	34695750	2022
22	Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control. ⁶²	Masip J...Rull A	35514981	2022
23	Simultaneous anterior cervical repair of type IV laryngeal cleft and tracheo-oesophageal fistula. ⁶²	Pandey G...Butler C	35039336	2022
24	The clinical application of flexible bronchoscopy in a neonatal intensive care unit. ⁶²	Ke LQ...Tang LF	36299699	2022
25	A Network of Anomalies Prompting VACTERL Workup in a Trisomy 21 Newborn. ⁶²	Reinicke T...Griggs C	35186552	2022
26	Clinical predictors of laryngotracheoesophageal clefts and tracheoesophageal fistulae in children with dysphagia. ⁶²	Mattos C...Piccione J	34387933	2021
27	Laryngeal cleft: A literature review. ⁶²	Martha VV...Sataloff RT	33957543	2021
28	Optimal timing and technique for endoscopic management of dysphagia in pediatric aerodigestive patients. ⁶²	Wineski RE...Smith N	34392101	2021
29	Esophageal Atresia and Respiratory Morbidity. ⁶²	Lejeune S...Gottrand F	34413249	2021
30	[Clinical diagnosis and treatments of type Ⅱ-Ⅳ congenital laryngotracheoesophageal cleft in 8 children]. ⁶²	Zhao J...Ni X	34666447	2021
31	Developmental basis of trachea-esophageal birth defects. ⁶²	Edwards NA...Zorn AM	34023332	2021
32	Type 2 laryngeal cleft associated with OpitzG/BBB syndrome. ⁶²	Garcia-Muro C...Navazo-Eguia A	34404523	2021
33	Congenital airway anomalies. ⁶²	Varela P...Schweiger C	34172206	2021
34	Tracheal anomalies associated with Down syndrome: A systematic review. ⁶²	Fockens MM...Dikkers FG	33434377	2021
35	Postoperative dysphagia immediately following pediatric endoscopic laryngeal cleft repair. ⁶²	Kiessling P...Balakrishnan K	33454453	2021
36	Type 3/4 laryngeal cleft. ⁶²	Field-Lucas E...Valsamakis T	32788392	2021
37	[Laryngotracheoesophageal cleft: Clinical presentation and surgical treatment]. ⁶²	Costa-Roig A...Gutierrez San Roman C	33423954	2021
38	Comorbidity and long-term clinical outcome of laryngotracheal clefts types III and IV: Systematic analysis of new cases. ⁶²	Seidl E...Reiter K	33095514	2021
39	Gross morphological, histological and scanning electron specifications of the oropharyngeal cavity of the hooded crow (Corvus cornix pallescens). ⁶²	Gewaily MS...Abumandour MMA	32794280	2021
40	Inter-rater reliability in diagnosis and treatment of type one laryngeal cleft: A blinded observational study. ⁶²	Newberry CI...Meier J	33130466	2020
41	Multidisciplinary approach to paediatric aerodigestive disorders: A single-centre longitudinal observational study. ⁶²	Fuladi A...Kapur N	32886957	2020
42	Current management of type III and IV laryngotracheoesophageal clefts: the case for a revised cleft classification. ⁶²	Jauregui EJ...Johnson K	33109943	2020
43	Prenatal diagnosis of laryngo-tracheo-esophageal anomalies in fetuses with congenital diaphragmatic hernia by ultrasound evaluation of the vocal cords and fetal laryngoesophagoscopy. ⁶²	Cruz-Martinez R...Favela-Heredia C	32743809	2020
44	Prematurity and associated future paediatric airway pathology: experience from a single tertiary paediatric ENT centre. ⁶²	Vakharia N...Hall A	32556789	2020
45	Presentation and management of type 1 laryngeal clefts: A systematic review and meta-analysis. ⁶²	Reddy P...White DR	33152963	2020
46	Familial and genetic factors in laryngeal cleft: Have we learned anything? ⁶²	Dombrowski ND...Rahbar R	32771712	2020
47	Fiber optic CO2-laser induced emphysema of the supraglottis. ⁶²	Arnold L...Gov-Ari E	32810687	2020
48	Purification of Lumbricus terrestris Mega-Hemoglobin for Diverse Oxygen Therapeutic Applications. ⁶²	Savla C...Palmer AF	33313397	2020
49	A Very Rare Complication of Hyaluronic Acid Injection for Medialization Laryngoplasty: A Case With Laryngeal Abscess. ⁶²	Enver N...Gurol E	31005447	2020
50	Purification of Lumbricus terrestris erythrocruorin (LtEc) with anion exchange chromatography. ⁶²	Timm B...Elmer J	32505113	2020

Sources

Genes for Laryngeal Cleft

Genes related to Laryngeal Cleft (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MID1	Midline 1	Protein Coding	8.09	GeneCards inferred via : Summaries (show sections)

Sources

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	overlap with 2 genes	GRCh37/hg19 7q36.3(chr7:156333296-156556779)	CN GAIN	Uncertain Significance	523286		GRCh37: 7:156333296-156556779 GRCh38:
2	overlap with 3 genes	GRCh37/hg19 7q36.3(chr7:156656444-156866708)	CN GAIN	Uncertain Significance	523287		GRCh37: 7:156656444-156866708 GRCh38:

Sources

Expression for Laryngeal Cleft

Search GEO for disease gene expression data for Laryngeal Cleft.

Sources

Pathways for Laryngeal Cleft

Sources

GO Terms for Laryngeal Cleft

Sources

Sources for Laryngeal Cleft

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

LC MCID: LRY026 MIFTS: 34	Laryngeal Cleft (LC) Categories: Fetal diseases, Oral diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Laryngeal Cleft (LC)

Aliases & Classifications for Laryngeal Cleft

MalaCards integrated aliases for Laryngeal Cleft:

Characteristics:

Inheritance:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Laryngeal Cleft

Related Diseases for Laryngeal Cleft

Diseases related to Laryngeal Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Laryngeal Cleft:

Symptoms & Phenotypes for Laryngeal Cleft

Human phenotypes related to Laryngeal Cleft:

Drugs & Therapeutics for Laryngeal Cleft

Drugs for Laryngeal Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Laryngeal Cleft

Anatomical Context for Laryngeal Cleft

Organs/tissues related to Laryngeal Cleft:

Publications for Laryngeal Cleft

Articles related to Laryngeal Cleft:

Genes for Laryngeal Cleft

Genes related to Laryngeal Cleft (0 elite genes):

Variations for Laryngeal Cleft

ClinVar genetic disease variations for Laryngeal Cleft:

Expression for Laryngeal Cleft

Pathways for Laryngeal Cleft

GO Terms for Laryngeal Cleft

Sources for Laryngeal Cleft