MCID: LRY013
MIFTS: 29

Laryngeal Neuroendocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor 12 58 15
Neuroendocrine Neoplasm of Larynx 71
Neuroendocrine Tumor of Larynx 12

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:5457
NCIt 49 C6023
Orphanet 58 ORPHA100083
UMLS 71 C1334374

Summaries for Laryngeal Neuroendocrine Tumor

MalaCards based summary : Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to neuroendocrine carcinoma and neuroendocrine tumor. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include thyroid, lung and breast, and related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 29.5 SYP NCAM1 CHGA CALCA
2 neuroendocrine tumor 28.8 SYP RET NCAM1 CHGA CALCA
3 paraganglioma 28.7 SYP RET NCAM1 CHGA CALCA
4 pancreatic cholera 10.2 CHGA CALCA
5 olfactory neuroblastoma 10.2 SYP CHGA
6 endobronchial lipoma 10.2 SYP NUTM1
7 primary hepatic neuroendocrine carcinoma 10.2 SYP CHGA
8 pancreas lymphoma 10.2 SYP CHGA
9 small cell carcinoma of the bladder 10.2 SYP CHGA
10 acinar cell cystadenocarcinoma 10.2 SYP CHGA
11 vulvar eccrine porocarcinoma 10.2 SYP CHGA
12 gastrointestinal neuroendocrine benign tumor 10.2 SYP CHGA
13 appendix carcinoid tumor 10.2 SYP CHGA
14 auditory system cancer 10.2 SYP CHGA
15 mixed ductal-endocrine carcinoma 10.2 SYP CHGA
16 thymus small cell carcinoma 10.2 SYP CHGA
17 breast papillary carcinoma 10.2 SYP CHGA
18 cauda equina neoplasm 10.2 SYP CHGA
19 duodenal benign neoplasm 10.2 SYP CHGA
20 ampulla of vater neoplasm 10.2 SYP CHGA
21 vaginal tubulovillous adenoma 10.2 SYP CHGA
22 vaginal adenoma 10.2 SYP CHGA
23 middle ear adenoma 10.2 SYP CHGA
24 nodular ganglioneuroblastoma 10.2 SYP CHGA
25 somatostatinoma 10.1 CHGA CALCA
26 gastric neuroendocrine neoplasm 10.1 SYP CHGA
27 vaginal benign neoplasm 10.1 SYP CHGA
28 sensory organ benign neoplasm 10.1 SYP CHGA
29 cervical neuroblastoma 10.1 SYP CHGA
30 pineocytoma 10.1 SYP CHGA
31 vipoma 10.1 CHGA CALCA
32 cervix small cell carcinoma 10.1 SYP CHGA
33 pancreatic gastrinoma 10.1 SYP CHGA
34 gastrointestinal neuroendocrine tumor 10.1 SYP CHGA
35 carcinoid tumors, intestinal 10.1 SYP CHGA
36 lung clear cell carcinoma 10.1 SYP CHGA
37 multiple endocrine neoplasia 10.1 RET CALCA
38 colon neuroendocrine neoplasm 10.1 SYP CHGA
39 binswanger's disease 10.1 SYP CHGA
40 pancreatic acinar cell adenocarcinoma 10.1 SYP CHGA
41 small intestine benign neoplasm 10.1 SYP CHGA
42 middle ear carcinoma 10.1 SYP CHGA
43 anal neuroendocrine tumor 10.1 SYP NCAM1
44 multiple mucosal neuroma 10.1 RET CALCA
45 gangliocytoma 10.1 SYP CHGA
46 lung combined type small cell carcinoma 10.1 SYP NCAM1
47 nonencapsulated sclerosing carcinoma 10.1 RET CALCA
48 cerebellopontine angle primitive neuroectodermal 10.1 SYP NCAM1
49 clear cell meningioma 10.1 SYP CHGA
50 pelvic lipomatosis 10.1 SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:



Diseases related to Laryngeal Neuroendocrine Tumor

Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

58 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neuroendocrine neoplasm 58 31 obligate (100%) Obligate (100%) HP:0100634
2 neoplasm of the larynx 58 31 obligate (100%) Obligate (100%) HP:0100605
3 dysphonia 58 31 frequent (33%) Frequent (79-30%) HP:0001618
4 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
5 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
6 chronic fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012432
7 increased serum serotonin 58 31 frequent (33%) Frequent (79-30%) HP:0003144
8 exertional dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002875
9 oral-pharyngeal dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0200136
10 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
11 elevated calcitonin 58 31 frequent (33%) Frequent (79-30%) HP:0003528
12 adrenocorticotropic hormone excess 58 31 very rare (1%) Very rare (<4-1%) HP:0011749
13 elevated carcinoembryonic antigen level 58 31 very rare (1%) Very rare (<4-1%) HP:0031029
14 inappropriate antidiuretic hormone secretion 58 31 very rare (1%) Very rare (<4-1%) HP:0031218

Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Laryngeal Neuroendocrine Tumor

Genetic Tests for Laryngeal Neuroendocrine Tumor

Anatomical Context for Laryngeal Neuroendocrine Tumor

MalaCards organs/tissues related to Laryngeal Neuroendocrine Tumor:

40
Thyroid, Lung, Breast, Ovary, Prostate, Thymus, Cortex

Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

# Title Authors PMID Year
1
Small-Cell Neuroendocrine Tumor of Larynx: A Rare Presentation. 61
31741918 2019
2
Small-cell neuroendocrine tumor of larynx: a rare presentation. 61
18417860 2008
3
Neuroendocrine tumors of the larynx: a clinical report and literature review. 61
16683387 2006
4
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. 61
14724913 2004

Variations for Laryngeal Neuroendocrine Tumor

Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

Pathways for Laryngeal Neuroendocrine Tumor

Pathways related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP RET NCAM1 CALCA

GO Terms for Laryngeal Neuroendocrine Tumor

Cellular components related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.62 SYP CALCA

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.96 CHGA CALCA
2 response to pain GO:0048265 8.62 RET CALCA

Molecular functions related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.62 TP53 SYP

Sources for Laryngeal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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