MCID: LRY013
MIFTS: 32

Laryngeal Neuroendocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor 11 58 14
Neuroendocrine Neoplasm of Larynx 71
Laryngeal Neuroendocrine Tumour 11
Neuroendocrine Tumour of Larynx 11
Neuroendocrine Tumor of Larynx 11

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Disease Ontology 11 DOID:5457
NCIt 49 C6023
SNOMED-CT 68 707625001
Orphanet 58 ORPHA100083
UMLS 71 C1334374

Summaries for Laryngeal Neuroendocrine Tumor

Orphanet: 58 A rare head and neck tumor characterized by an epithelial neoplasm with evidence of neuroendocrine differentiation, typically located in the supraglottic larynx. The tumor can be well, moderately, or poorly differentiated, the latter group being subdivided into small cell or large cell neuroendocrine carcinomas. There is a strong association with tobacco use. Patients present with hoarseness, dysphagia, sore throat, airway obstruction, hemoptysis, and rarely a paraneoplastic syndrome due to aberrant hormone production. Poorly differentiated tumors are highly aggressive with high rates of regional and distant metastasis.

MalaCards based summary: Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to thyroid carcinoma, familial medullary and thyroid gland medullary carcinoma. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways are Neuroscience and GDNF signaling. Related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma, familial medullary 29.8 RET NKX2-1 CHGA CALCA
2 thyroid gland medullary carcinoma 29.3 SYP RET PAX8 NKX2-1 CHGA CALCA
3 neuroendocrine carcinoma 28.8 SYP NKX2-1 NCAM1 KRT19 ENO2 CHGA
4 paraganglioma 28.5 SYP RET NKX2-1 NCAM1 KRT19 ENO2
5 neuroendocrine tumor 28.1 SYP RET PAX8 NKX2-1 NCAM1 KRT19
6 pancreas lymphoma 10.3 SYP CHGA
7 pancreatic cholera 10.3 CHGA CALCA
8 vaginal tubulovillous adenoma 10.3 SYP CHGA
9 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
10 vulvar eccrine porocarcinoma 10.3 SYP CHGA
11 substernal goiter 10.3 RET CALCA
12 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
13 duodenal benign neoplasm 10.3 SYP CHGA
14 nonsyndromic paraganglioma 10.3 RET CHGA
15 endocrine pancreas disease 10.3 CHGA CALCA
16 multiple mucosal neuroma 10.3 RET CALCA
17 breast papillary carcinoma 10.3 SYP CHGA
18 gastric gastrinoma 10.3 SYP CHGA
19 nonencapsulated sclerosing carcinoma 10.3 RET CALCA
20 binswanger's disease 10.3 SYP CHGA
21 benign perivascular tumor 10.3 SYP CHGA
22 duodenal gastrinoma 10.3 SYP CHGA
23 glomangioma 10.3 SYP CHGA
24 pancreatic gastrinoma 10.3 SYP CHGA
25 benign ileal neoplasm 10.3 SYP CHGA
26 ovarian mucinous cystadenofibroma 10.3 SYP NCAM1
27 ovarian mucinous adenofibroma 10.3 SYP NCAM1
28 isthmus cancer 10.3 NCAM1 CALCA
29 mucinous adenofibroma 10.3 SYP NCAM1
30 thyroid gland hurthle cell carcinoma 10.3 SYP CHGA
31 thyroid angiosarcoma 10.3 PAX8 CALCA
32 thyroid lymphoma 10.3 RET CALCA
33 vaginal adenoma 10.3 SYP CHGA
34 cauda equina syndrome 10.2 SYP CALCA
35 vaginal benign neoplasm 10.2 SYP CHGA
36 mucinous cystadenofibroma 10.2 SYP PAX8
37 glycogen-rich clear cell breast carcinoma 10.2 SYP PAX8
38 bilateral hypoactive labyrinth 10.2 SYP NCAM1
39 spindle epithelial tumor with thymus-like differentiation tumor 10.2 NKX2-1 CALCA
40 gastric hemangioma 10.2 NCAM1 CHGA
41 papillary thyroid microcarcinoma 10.2 NKX2-1 CALCA
42 prostatic acinar adenocarcinoma 10.2 SYP PAX8
43 prostate stromal sarcoma 10.2 SYP NCAM1
44 krukenberg carcinoma 10.2 SYP PAX8
45 lung meningioma 10.2 SYP NKX2-1
46 internal auditory canal lipoma 10.2 PTCH1 NUTM1
47 rete testis adenoma 10.2 PAX8 NCAM1
48 endemic goiter 10.2 PAX8 CALCA
49 ectopic thymus 10.2 NKX2-1 CALCA
50 pancreatic endocrine carcinoma 10.2 SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:



Diseases related to Laryngeal Neuroendocrine Tumor

Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

58 30 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neuroendocrine neoplasm 58 30 Obligate (100%) Obligate (100%)
HP:0100634
2 neoplasm of the larynx 58 30 Obligate (100%) Obligate (100%)
HP:0100605
3 dysphonia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001618
4 anorexia 58 30 Frequent (33%) Frequent (79-30%)
HP:0002039
5 chronic fatigue 58 30 Frequent (33%) Frequent (79-30%)
HP:0012432
6 weight loss 58 30 Frequent (33%) Frequent (79-30%)
HP:0001824
7 exertional dyspnea 58 30 Frequent (33%) Frequent (79-30%)
HP:0002875
8 oral-pharyngeal dysphagia 58 30 Frequent (33%) Frequent (79-30%)
HP:0200136
9 elevated calcitonin 58 30 Frequent (33%) Frequent (79-30%)
HP:0003528
10 chronic noninfectious lymphadenopathy 58 30 Frequent (33%) Frequent (79-30%)
HP:0002730
11 increased serum serotonin 58 30 Frequent (33%) Frequent (79-30%)
HP:0003144
12 adrenocorticotropic hormone excess 58 30 Very rare (1%) Very rare (<4-1%)
HP:0011749
13 elevated carcinoembryonic antigen level 58 30 Very rare (1%) Very rare (<4-1%)
HP:0031029
14 inappropriate antidiuretic hormone secretion 58 30 Very rare (1%) Very rare (<4-1%)
HP:0031218

MGI Mouse Phenotypes related to Laryngeal Neuroendocrine Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.14 CALCA CHGA ENO2 KRT19 NCAM1 NKX2-1
2 normal MP:0002873 10.06 CALCA KRT19 NKX2-1 PAX8 PTCH1 RET
3 no phenotypic analysis MP:0003012 9.98 CHGA KRT19 NKX2-1 PAX8 PTCH1 RET
4 endocrine/exocrine gland MP:0005379 9.97 CHGA KRT19 NKX2-1 NUTM1 PAX8 PTCH1
5 cellular MP:0005384 9.97 ENO2 KRT19 NCAM1 NKX2-1 NUTM1 PAX8
6 neoplasm MP:0002006 9.95 CALCA KRT19 NKX2-1 PTCH1 RET TP53
7 cardiovascular system MP:0005385 9.86 CALCA CHGA KRT19 NKX2-1 PAX8 PTCH1
8 behavior/neurological MP:0005386 9.81 CALCA ENO2 NCAM1 NKX2-1 PAX8 PTCH1
9 respiratory system MP:0005388 9.5 CALCA ENO2 KRT19 NKX2-1 PTCH1 RET
10 reproductive system MP:0005389 9.23 CHGA KRT19 NKX2-1 NUTM1 PAX8 PTCH1

Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials, NIH Clinical Center for Laryngeal Neuroendocrine Tumor

Genetic Tests for Laryngeal Neuroendocrine Tumor

Anatomical Context for Laryngeal Neuroendocrine Tumor

Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

# Title Authors PMID Year
1
Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature. 62
32765421 2020
2
Small-Cell Neuroendocrine Tumor of Larynx: A Rare Presentation. 62
31741918 2019
3
Small-cell neuroendocrine tumor of larynx: a rare presentation. 62
18417860 2008
4
Neuroendocrine tumors of the larynx: a clinical report and literature review. 62
16683387 2006
5
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. 62
14724913 2004
6
Laryngeal neuroendocrine tumour with features of a paraganglioma, intracytoplasmic lumina and acinar formation. 62
2579884 1985

Variations for Laryngeal Neuroendocrine Tumor

Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

Pathways for Laryngeal Neuroendocrine Tumor

Pathways related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 SYP RET NKX2-1 NCAM1 ENO2 CALCA
2 11.25 SYP RET NCAM1
3 10.55 PTCH1 NCAM1

GO Terms for Laryngeal Neuroendocrine Tumor

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to xenobiotic stimulus GO:0009410 9.5 TP53 RET PTCH1 ENO2
2 commissural neuron axon guidance GO:0071679 8.92 PTCH1 NCAM1

Sources for Laryngeal Neuroendocrine Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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