MCID: LRY013
MIFTS: 30

Laryngeal Neuroendocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor 12 58 15
Neuroendocrine Neoplasm of Larynx 70
Laryngeal Neuroendocrine Tumour 12
Neuroendocrine Tumour of Larynx 12
Neuroendocrine Tumor of Larynx 12

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:5457
NCIt 50 C6023
SNOMED-CT 67 707625001
Orphanet 58 ORPHA100083
UMLS 70 C1334374

Summaries for Laryngeal Neuroendocrine Tumor

MalaCards based summary : Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to thyroid carcinoma, familial medullary and thyroid gland medullary carcinoma. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1). Affiliated tissues include thyroid, lung and breast, and related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma, familial medullary 29.9 SST CHGA CALCA
2 thyroid gland medullary carcinoma 29.7 SYP SST CHGA CALCA
3 neuroendocrine carcinoma 29.1 SYP SST NCAM1 CHGA CALCA
4 paraganglioma 29.0 SYP SST NCAM1 CHGA CALCA
5 neuroendocrine tumor 29.0 SYP SST NCAM1 CHGA CALCA
6 olfactory neuroblastoma 10.3 SYP CHGA
7 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
8 auditory system benign neoplasm 10.3 SYP CHGA
9 auditory system cancer 10.3 SYP CHGA
10 acinar cell cystadenocarcinoma 10.3 SYP CHGA
11 vulvar eccrine porocarcinoma 10.3 SYP CHGA
12 cauda equina neoplasm 10.3 SYP CHGA
13 appendix carcinoid tumor 10.3 SYP CHGA
14 endobronchial lipoma 10.3 SYP NUTM1
15 vaginal tubulovillous adenoma 10.3 SYP CHGA
16 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
17 middle ear adenoma 10.3 SYP CHGA
18 breast papillary carcinoma 10.3 SYP CHGA
19 appendix adenocarcinoma 10.3 SYP CHGA
20 pineocytoma 10.3 SYP CHGA
21 cervix small cell carcinoma 10.2 SYP CHGA
22 adrenal neuroblastoma 10.2 SYP CHGA
23 vaginal adenoma 10.2 SYP CHGA
24 vaginal benign neoplasm 10.2 SYP CHGA
25 pancreatic acinar cell adenocarcinoma 10.2 SYP CHGA
26 optic nerve astrocytoma 10.2 SYP SMARCB1
27 extra-adrenal pheochromocytoma 10.2 SYP CHGA
28 pineal region teratoma 10.2 SYP SMARCB1
29 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 CHGA
30 kidney rhabdoid cancer 10.2 SYP SMARCB1
31 horseshoe kidney 10.2 SYP CHGA
32 microcystic adenoma 10.2 SYP CHGA
33 pulmonary sclerosing hemangioma 10.2 SYP CHGA
34 rhabdoid meningioma 10.2 SYP SMARCB1
35 pineal gland cancer 10.2 SYP SMARCB1
36 eccrine sweat gland cancer 10.2 TP53 NUTM1
37 melanotic medulloblastoma 10.2 SMARCB1 PTCH1
38 central epithelioid sarcoma 10.2 SYP SMARCB1
39 vulvar proximal-type epithelioid sarcoma 10.2 SYP SMARCB1
40 pancreatic somatostatinoma 10.2 SST CALCA
41 adult teratoma 10.2 TP53 CHGA
42 ependymoblastoma 10.2 SYP SMARCB1
43 non-functioning pancreatic endocrine tumor 10.2 SST CHGA
44 extraosseous chondrosarcoma 10.2 SYP SMARCB1
45 ovarian small cell carcinoma 10.2 SYP SMARCB1
46 duodenal gastrinoma 10.2 SST CHGA
47 cecal disease 10.2 SYP CHGA
48 appendix lymphoma 10.2 SST CHGA
49 cerebellar medulloblastoma 10.2 SYP PTCH1
50 sarcomatoid transitional cell carcinoma 10.2 TP53 SYP

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:



Diseases related to Laryngeal Neuroendocrine Tumor

Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

58 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neuroendocrine neoplasm 58 31 obligate (100%) Obligate (100%) HP:0100634
2 neoplasm of the larynx 58 31 obligate (100%) Obligate (100%) HP:0100605
3 dysphonia 58 31 frequent (33%) Frequent (79-30%) HP:0001618
4 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
5 chronic fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012432
6 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
7 exertional dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002875
8 oral-pharyngeal dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0200136
9 elevated calcitonin 58 31 frequent (33%) Frequent (79-30%) HP:0003528
10 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
11 increased serum serotonin 58 31 frequent (33%) Frequent (79-30%) HP:0003144
12 adrenocorticotropic hormone excess 58 31 very rare (1%) Very rare (<4-1%) HP:0011749
13 elevated carcinoembryonic antigen level 58 31 very rare (1%) Very rare (<4-1%) HP:0031029
14 inappropriate antidiuretic hormone secretion 58 31 very rare (1%) Very rare (<4-1%) HP:0031218

GenomeRNAi Phenotypes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Laryngeal Neuroendocrine Tumor

Genetic Tests for Laryngeal Neuroendocrine Tumor

Anatomical Context for Laryngeal Neuroendocrine Tumor

MalaCards organs/tissues related to Laryngeal Neuroendocrine Tumor:

40
Thyroid, Lung, Breast, Appendix, Bone, Brain, Kidney

Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

# Title Authors PMID Year
1
Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature. 61
32765421 2020
2
Neuroendocrine tumors of the larynx: a clinical report and literature review. 61
16683387 2006
3
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. 61
14724913 2004

Variations for Laryngeal Neuroendocrine Tumor

Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

Pathways for Laryngeal Neuroendocrine Tumor

GO Terms for Laryngeal Neuroendocrine Tumor

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.26 TP53 SST SMARCB1 PTCH1
2 response to steroid hormone GO:0048545 9.16 SST IDH1
3 commissural neuron axon guidance GO:0071679 8.62 PTCH1 NCAM1

Sources for Laryngeal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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