MCID: LRY013
MIFTS: 21

Laryngeal Neuroendocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor 12 59 15
Neuroendocrine Neoplasm of Larynx 72
Neuroendocrine Tumor of Larynx 12

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:5457
NCIt 50 C6023
Orphanet 59 ORPHA100083
UMLS 72 C1334374

Summaries for Laryngeal Neuroendocrine Tumor

MalaCards based summary : Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to neuroendocrine tumor and paraganglioma. An important gene associated with Laryngeal Neuroendocrine Tumor is CHGA (Chromogranin A). Related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 29.7 CHGA CALCA
2 paraganglioma 10.1
3 neuroendocrine carcinoma 10.1
4 lung oat cell carcinoma 10.1 CHGA CALCA
5 acute thyroiditis 10.0 CHGA CALCA
6 somatostatinoma 10.0 CHGA CALCA
7 carcinoid syndrome 10.0 CHGA CALCA
8 extragonadal seminoma 10.0 NUTM1 CALCA
9 diffuse pulmonary fibrosis 10.0 CHGA CALCA
10 malignant pheochromocytoma 10.0 CHGA CALCA
11 islet cell tumor 10.0 CHGA CALCA
12 endocrine organ benign neoplasm 10.0 CHGA CALCA
13 multiple endocrine neoplasia 10.0 CHGA CALCA
14 parathyroid adenoma 9.9 CHGA CALCA
15 cellular ependymoma 9.9 TP53 CHGA
16 fibroepithelial basal cell carcinoma 9.9 TP53 CHGA
17 olfactory groove meningioma 9.9 TP53 CHGA
18 mucoepidermoid carcinoma 9.9 CHGA CALCA
19 anterior cranial fossa meningioma 9.9 TP53 CHGA
20 pleomorphic xanthoastrocytoma 9.9 TP53 CHGA
21 pulmonary blastoma 9.9 TP53 CHGA
22 primary hyperparathyroidism 9.8 CHGA CALCA
23 cervix small cell carcinoma 9.8 TP53 CHGA
24 cerebellar liponeurocytoma 9.8 TP53 CHGA
25 hyperparathyroidism 9.8 CHGA CALCA
26 granulosa cell tumor of the ovary 9.8 TP53 CHGA
27 dyskeratosis congenita 9.8 TP53 NUTM1
28 dyskeratosis congenita autosomal recessive 9.8 TP53 NUTM1
29 acinar cell carcinoma 9.8 TP53 CHGA
30 gastrointestinal system benign neoplasm 9.8 TP53 CHGA
31 ganglioglioma 9.8 TP53 CHGA
32 lung benign neoplasm 9.8 TP53 CHGA
33 prolactin producing pituitary tumor 9.8 TP53 CALCA
34 thyroid carcinoma, familial medullary 9.8 CHGA CALCA
35 atrophic gastritis 9.8 TP53 CHGA
36 cell type benign neoplasm 9.7 TP53 CHGA
37 merkel cell carcinoma 9.7 TP53 CHGA
38 male reproductive organ cancer 9.7 TP53 CHGA
39 male reproductive system disease 9.7 TP53 CHGA
40 suppression of tumorigenicity 12 9.6 TP53 CHGA
41 adrenocortical carcinoma, hereditary 9.5 TP53 CHGA
42 gastrointestinal stromal tumor 9.5 TP53 CHGA
43 thyroid cancer, nonmedullary, 2 9.4 CHGA CALCA
44 atypical follicular adenoma 9.3 TP53 CHGA CALCA
45 small cell carcinoma 9.3 TP53 CHGA CALCA
46 endocrine gland cancer 9.3 TP53 CHGA CALCA
47 small cell cancer of the lung 9.3 TP53 CHGA CALCA
48 breast adenocarcinoma 9.3 TP53 CALCA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:



Diseases related to Laryngeal Neuroendocrine Tumor

Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

59 32 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neuroendocrine neoplasm 59 32 obligate (100%) Obligate (100%) HP:0100634
2 neoplasm of the larynx 59 32 obligate (100%) Obligate (100%) HP:0100605
3 dysphonia 59 32 frequent (33%) Frequent (79-30%) HP:0001618
4 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
5 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
6 chronic fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012432
7 increased serum serotonin 59 32 frequent (33%) Frequent (79-30%) HP:0003144
8 exertional dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002875
9 oral-pharyngeal dysphagia 59 32 frequent (33%) Frequent (79-30%) HP:0200136
10 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
11 elevated calcitonin 59 32 frequent (33%) Frequent (79-30%) HP:0003528
12 adrenocorticotropic hormone excess 59 32 very rare (1%) Very rare (<4-1%) HP:0011749
13 elevated carcinoembryonic antigen level 59 32 very rare (1%) Very rare (<4-1%) HP:0031029
14 inappropriate antidiuretic hormone secretion 59 32 very rare (1%) Very rare (<4-1%) HP:0031218

Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Laryngeal Neuroendocrine Tumor

Genetic Tests for Laryngeal Neuroendocrine Tumor

Anatomical Context for Laryngeal Neuroendocrine Tumor

Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

# Title Authors PMID Year
1
Small-cell neuroendocrine tumor of larynx: a rare presentation. 38
18417860 2008
2
Neuroendocrine tumors of the larynx: a clinical report and literature review. 38
16683387 2006
3
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. 38
14724913 2004

Variations for Laryngeal Neuroendocrine Tumor

Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

Pathways for Laryngeal Neuroendocrine Tumor

GO Terms for Laryngeal Neuroendocrine Tumor

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.62 CHGA CALCA

Sources for Laryngeal Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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