Laryngeal Neuroendocrine Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor ¹² ⁵⁸ ¹⁵

Neuroendocrine Neoplasm of Larynx ⁷¹

Neuroendocrine Tumor of Larynx ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Respiratory diseases Neuronal diseases Oral diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare endocrine diseases

External Ids:

Disease Ontology ¹² DOID:5457

NCIt ⁴⁹ C6023

Orphanet ⁵⁸ ORPHA100083

SNOMED-CT via HPO ⁶⁸ 126692004 128928004 161832001 more

UMLS ⁷¹ C1334374

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Summaries for Laryngeal Neuroendocrine Tumor

MalaCards based summary : Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to neuroendocrine carcinoma and neuroendocrine tumor. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include thyroid, lung and breast, and related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

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Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine carcinoma	29.5	SYP NCAM1 CHGA CALCA
2	neuroendocrine tumor	28.8	SYP RET NCAM1 CHGA CALCA
3	paraganglioma	28.7	SYP RET NCAM1 CHGA CALCA
4	pancreatic cholera	10.2	CHGA CALCA
5	olfactory neuroblastoma	10.2	SYP CHGA
6	endobronchial lipoma	10.2	SYP NUTM1
7	primary hepatic neuroendocrine carcinoma	10.2	SYP CHGA
8	pancreas lymphoma	10.2	SYP CHGA
9	small cell carcinoma of the bladder	10.2	SYP CHGA
10	acinar cell cystadenocarcinoma	10.2	SYP CHGA
11	vulvar eccrine porocarcinoma	10.2	SYP CHGA
12	gastrointestinal neuroendocrine benign tumor	10.2	SYP CHGA
13	appendix carcinoid tumor	10.2	SYP CHGA
14	auditory system cancer	10.2	SYP CHGA
15	mixed ductal-endocrine carcinoma	10.2	SYP CHGA
16	thymus small cell carcinoma	10.2	SYP CHGA
17	breast papillary carcinoma	10.2	SYP CHGA
18	cauda equina neoplasm	10.2	SYP CHGA
19	duodenal benign neoplasm	10.2	SYP CHGA
20	ampulla of vater neoplasm	10.2	SYP CHGA
21	vaginal tubulovillous adenoma	10.2	SYP CHGA
22	vaginal adenoma	10.2	SYP CHGA
23	middle ear adenoma	10.2	SYP CHGA
24	nodular ganglioneuroblastoma	10.2	SYP CHGA
25	somatostatinoma	10.1	CHGA CALCA
26	gastric neuroendocrine neoplasm	10.1	SYP CHGA
27	vaginal benign neoplasm	10.1	SYP CHGA
28	sensory organ benign neoplasm	10.1	SYP CHGA
29	cervical neuroblastoma	10.1	SYP CHGA
30	pineocytoma	10.1	SYP CHGA
31	vipoma	10.1	CHGA CALCA
32	cervix small cell carcinoma	10.1	SYP CHGA
33	pancreatic gastrinoma	10.1	SYP CHGA
34	gastrointestinal neuroendocrine tumor	10.1	SYP CHGA
35	carcinoid tumors, intestinal	10.1	SYP CHGA
36	lung clear cell carcinoma	10.1	SYP CHGA
37	multiple endocrine neoplasia	10.1	RET CALCA
38	colon neuroendocrine neoplasm	10.1	SYP CHGA
39	binswanger's disease	10.1	SYP CHGA
40	pancreatic acinar cell adenocarcinoma	10.1	SYP CHGA
41	small intestine benign neoplasm	10.1	SYP CHGA
42	middle ear carcinoma	10.1	SYP CHGA
43	anal neuroendocrine tumor	10.1	SYP NCAM1
44	multiple mucosal neuroma	10.1	RET CALCA
45	gangliocytoma	10.1	SYP CHGA
46	lung combined type small cell carcinoma	10.1	SYP NCAM1
47	nonencapsulated sclerosing carcinoma	10.1	RET CALCA
48	cerebellopontine angle primitive neuroectodermal	10.1	SYP NCAM1
49	clear cell meningioma	10.1	SYP CHGA
50	pelvic lipomatosis	10.1	SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:

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Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

⁵⁸ ³¹ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	neuroendocrine neoplasm ⁵⁸ ³¹	obligate (100%)	Obligate (100%)	HP:0100634
2	neoplasm of the larynx ⁵⁸ ³¹	obligate (100%)	Obligate (100%)	HP:0100605
3	dysphonia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001618
4	weight loss ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001824
5	anorexia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002039
6	chronic fatigue ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0012432
7	increased serum serotonin ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003144
8	exertional dyspnea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002875
9	oral-pharyngeal dysphagia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0200136
10	chronic noninfectious lymphadenopathy ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002730
11	elevated calcitonin ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003528
12	adrenocorticotropic hormone excess ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0011749
13	elevated carcinoembryonic antigen level ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0031029
14	inappropriate antidiuretic hormone secretion ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0031218

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Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Laryngeal Neuroendocrine Tumor

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Genetic Tests for Laryngeal Neuroendocrine Tumor

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Anatomical Context for Laryngeal Neuroendocrine Tumor

MalaCards organs/tissues related to Laryngeal Neuroendocrine Tumor:

⁴⁰

Thyroid, Lung, Breast, Ovary, Prostate, Thymus, Cortex

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Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

#	Title	Authors	PMID	Year
1	Small-Cell Neuroendocrine Tumor of Larynx: A Rare Presentation. ⁶¹	Pavan Kumar L...Triveni B	31741918	2019
2	Small-cell neuroendocrine tumor of larynx: a rare presentation. ⁶¹	Dhingra M...Singh SN	18417860	2008
3	Neuroendocrine tumors of the larynx: a clinical report and literature review. ⁶¹	Procopio G...Bajetta E	16683387	2006
4	Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. ⁶¹	Del Gaudio JM...Muller S	14724913	2004

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Genes for Laryngeal Neuroendocrine Tumor

Genes related to Laryngeal Neuroendocrine Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	6.17	DISEASES inferred ¹⁵
2	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.49	DISEASES inferred ¹⁵
3	CHGA	Chromogranin A	Protein Coding	5.37	DISEASES inferred ¹⁵
4	SYP	Synaptophysin	Protein Coding	4.81	DISEASES inferred ¹⁵
5	RET	Ret Proto-Oncogene	Protein Coding	4.8	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	3.68	DISEASES inferred ¹⁵
7	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.34	DISEASES inferred ¹⁵

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Variations for Laryngeal Neuroendocrine Tumor

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Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

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Pathways for Laryngeal Neuroendocrine Tumor

Pathways related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.46	SYP RET NCAM1 CALCA

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GO Terms for Laryngeal Neuroendocrine Tumor

Cellular components related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	terminal bouton	GO:0043195	8.62	SYP CALCA

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:0008217	8.96	CHGA CALCA
2	response to pain	GO:0048265	8.62	RET CALCA

Molecular functions related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein self-association	GO:0043621	8.62	TP53 SYP

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Sources for Laryngeal Neuroendocrine Tumor

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⁷⁴ Wikipedia