Laryngeal Neuroendocrine Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor ¹¹ ⁵⁸ ¹⁴

Neuroendocrine Neoplasm of Larynx ⁷¹

Laryngeal Neuroendocrine Tumour ¹¹

Neuroendocrine Tumour of Larynx ¹¹

Neuroendocrine Tumor of Larynx ¹¹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Respiratory diseases Neuronal diseases Oral diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare endocrine diseases

External Ids:

Disease Ontology ¹¹ DOID:5457

NCIt ⁴⁹ C6023

SNOMED-CT ⁶⁸ 707625001

Orphanet ⁵⁸ ORPHA100083

SNOMED-CT via HPO ⁶⁹ 126692004 128928004 161832001 more

UMLS ⁷¹ C1334374

Sources

Summaries for Laryngeal Neuroendocrine Tumor

Orphanet: ⁵⁸ A rare head and neck tumor characterized by an epithelial neoplasm with evidence of neuroendocrine differentiation, typically located in the supraglottic larynx. The tumor can be well, moderately, or poorly differentiated, the latter group being subdivided into small cell or large cell neuroendocrine carcinomas. There is a strong association with tobacco use. Patients present with hoarseness, dysphagia, sore throat, airway obstruction, hemoptysis, and rarely a paraneoplastic syndrome due to aberrant hormone production. Poorly differentiated tumors are highly aggressive with high rates of regional and distant metastasis.

MalaCards based summary: Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to thyroid carcinoma, familial medullary and thyroid gland medullary carcinoma. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways are Neuroscience and GDNF signaling. Related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

Sources

Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)

#	Related Disease	Score	Top Affiliating Genes
1	thyroid carcinoma, familial medullary	29.8	RET NKX2-1 CHGA CALCA
2	thyroid gland medullary carcinoma	29.3	SYP RET PAX8 NKX2-1 CHGA CALCA
3	neuroendocrine carcinoma	28.8	SYP NKX2-1 NCAM1 KRT19 ENO2 CHGA
4	paraganglioma	28.5	SYP RET NKX2-1 NCAM1 KRT19 ENO2
5	neuroendocrine tumor	28.1	SYP RET PAX8 NKX2-1 NCAM1 KRT19
6	pancreas lymphoma	10.3	SYP CHGA
7	pancreatic cholera	10.3	CHGA CALCA
8	vaginal tubulovillous adenoma	10.3	SYP CHGA
9	mixed ductal-endocrine carcinoma	10.3	SYP CHGA
10	vulvar eccrine porocarcinoma	10.3	SYP CHGA
11	substernal goiter	10.3	RET CALCA
12	cervical large cell neuroendocrine carcinoma	10.3	SYP CHGA
13	duodenal benign neoplasm	10.3	SYP CHGA
14	nonsyndromic paraganglioma	10.3	RET CHGA
15	endocrine pancreas disease	10.3	CHGA CALCA
16	multiple mucosal neuroma	10.3	RET CALCA
17	breast papillary carcinoma	10.3	SYP CHGA
18	gastric gastrinoma	10.3	SYP CHGA
19	nonencapsulated sclerosing carcinoma	10.3	RET CALCA
20	binswanger's disease	10.3	SYP CHGA
21	benign perivascular tumor	10.3	SYP CHGA
22	duodenal gastrinoma	10.3	SYP CHGA
23	glomangioma	10.3	SYP CHGA
24	pancreatic gastrinoma	10.3	SYP CHGA
25	benign ileal neoplasm	10.3	SYP CHGA
26	ovarian mucinous cystadenofibroma	10.3	SYP NCAM1
27	ovarian mucinous adenofibroma	10.3	SYP NCAM1
28	isthmus cancer	10.3	NCAM1 CALCA
29	mucinous adenofibroma	10.3	SYP NCAM1
30	thyroid gland hurthle cell carcinoma	10.3	SYP CHGA
31	thyroid angiosarcoma	10.3	PAX8 CALCA
32	thyroid lymphoma	10.3	RET CALCA
33	vaginal adenoma	10.3	SYP CHGA
34	cauda equina syndrome	10.2	SYP CALCA
35	vaginal benign neoplasm	10.2	SYP CHGA
36	mucinous cystadenofibroma	10.2	SYP PAX8
37	glycogen-rich clear cell breast carcinoma	10.2	SYP PAX8
38	bilateral hypoactive labyrinth	10.2	SYP NCAM1
39	spindle epithelial tumor with thymus-like differentiation tumor	10.2	NKX2-1 CALCA
40	gastric hemangioma	10.2	NCAM1 CHGA
41	papillary thyroid microcarcinoma	10.2	NKX2-1 CALCA
42	prostatic acinar adenocarcinoma	10.2	SYP PAX8
43	prostate stromal sarcoma	10.2	SYP NCAM1
44	krukenberg carcinoma	10.2	SYP PAX8
45	lung meningioma	10.2	SYP NKX2-1
46	internal auditory canal lipoma	10.2	PTCH1 NUTM1
47	rete testis adenoma	10.2	PAX8 NCAM1
48	endemic goiter	10.2	PAX8 CALCA
49	ectopic thymus	10.2	NKX2-1 CALCA
50	pancreatic endocrine carcinoma	10.2	SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:

Sources

Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

⁵⁸ ³⁰ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	neuroendocrine neoplasm ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0100634
2	neoplasm of the larynx ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0100605
3	dysphonia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001618
4	anorexia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002039
5	chronic fatigue ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012432
6	weight loss ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001824
7	exertional dyspnea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002875
8	oral-pharyngeal dysphagia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0200136
9	elevated calcitonin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003528
10	chronic noninfectious lymphadenopathy ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002730
11	increased serum serotonin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003144
12	adrenocorticotropic hormone excess ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0011749
13	elevated carcinoembryonic antigen level ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0031029
14	inappropriate antidiuretic hormone secretion ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0031218

MGI Mouse Phenotypes related to Laryngeal Neuroendocrine Tumor:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.14	CALCA CHGA ENO2 KRT19 NCAM1 NKX2-1
2	normal	MP:0002873	10.06	CALCA KRT19 NKX2-1 PAX8 PTCH1 RET
3	no phenotypic analysis	MP:0003012	9.98	CHGA KRT19 NKX2-1 PAX8 PTCH1 RET
4	endocrine/exocrine gland	MP:0005379	9.97	CHGA KRT19 NKX2-1 NUTM1 PAX8 PTCH1
5	cellular	MP:0005384	9.97	ENO2 KRT19 NCAM1 NKX2-1 NUTM1 PAX8
6	neoplasm	MP:0002006	9.95	CALCA KRT19 NKX2-1 PTCH1 RET TP53
7	cardiovascular system	MP:0005385	9.86	CALCA CHGA KRT19 NKX2-1 PAX8 PTCH1
8	behavior/neurological	MP:0005386	9.81	CALCA ENO2 NCAM1 NKX2-1 PAX8 PTCH1
9	respiratory system	MP:0005388	9.5	CALCA ENO2 KRT19 NKX2-1 PTCH1 RET
10	reproductive system	MP:0005389	9.23	CHGA KRT19 NKX2-1 NUTM1 PAX8 PTCH1

Sources

Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials, NIH Clinical Center for Laryngeal Neuroendocrine Tumor

Sources

Genetic Tests for Laryngeal Neuroendocrine Tumor

Sources

Anatomical Context for Laryngeal Neuroendocrine Tumor

Sources

Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

#	Title	Authors	PMID	Year
1	Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature. ⁶²	Feola T...Giannetta E	32765421	2020
2	Small-Cell Neuroendocrine Tumor of Larynx: A Rare Presentation. ⁶²	Pavan Kumar L...Triveni B	31741918	2019
3	Small-cell neuroendocrine tumor of larynx: a rare presentation. ⁶²	Dhingra M...Singh SN	18417860	2008
4	Neuroendocrine tumors of the larynx: a clinical report and literature review. ⁶²	Procopio G...Bajetta E	16683387	2006
5	Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. ⁶²	Del Gaudio JM...Muller S	14724913	2004
6	Laryngeal neuroendocrine tumour with features of a paraganglioma, intracytoplasmic lumina and acinar formation. ⁶²	Spagnolo DV...Paradinas FJ	2579884	1985

Sources

Genes for Laryngeal Neuroendocrine Tumor

Genes related to Laryngeal Neuroendocrine Tumor (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	5.47	DISEASES inferred ¹⁴
2	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.38	DISEASES inferred ¹⁴
3	CHGA	Chromogranin A	Protein Coding	4.97	DISEASES inferred ¹⁴
4	SYP	Synaptophysin	Protein Coding	4.44	DISEASES inferred ¹⁴
5	RET	Ret Proto-Oncogene	Protein Coding	4.42	DISEASES inferred ¹⁴
6	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.37	DISEASES inferred ¹⁴
7	PAX8	Paired Box 8	Protein Coding	3.28	DISEASES inferred ¹⁴
8	NKX2-1	NK2 Homeobox 1	Protein Coding	3.16	DISEASES inferred ¹⁴
9	PTCH1	Patched 1	Protein Coding	3.05	DISEASES inferred ¹⁴
10	KRT19	Keratin 19	Protein Coding	2.94	DISEASES inferred ¹⁴
11	TP53	Tumor Protein P53	Protein Coding	2.88	DISEASES inferred ¹⁴
12	ENO2	Enolase 2	Protein Coding	2.8	DISEASES inferred ¹⁴

Sources

Variations for Laryngeal Neuroendocrine Tumor

Sources

Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

Sources

Pathways for Laryngeal Neuroendocrine Tumor

Pathways related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	11.63	SYP RET NKX2-1 NCAM1 ENO2 CALCA
2	GDNF signaling ⁷⁴	11.25	SYP RET NCAM1
3	Hair follicle development: organogenesis - part 2 of 3 ⁷⁴	10.55	PTCH1 NCAM1

Sources

GO Terms for Laryngeal Neuroendocrine Tumor

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to xenobiotic stimulus	GO:0009410	9.5	TP53 RET PTCH1 ENO2
2	commissural neuron axon guidance	GO:0071679	8.92	PTCH1 NCAM1

Sources

Sources for Laryngeal Neuroendocrine Tumor

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRY013 MIFTS: 32	Laryngeal Neuroendocrine Tumor Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Publications Symptoms & Phenotypes Expand all tables