Laryngeal Neuroendocrine Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Laryngeal Neuroendocrine Tumor

MalaCards integrated aliases for Laryngeal Neuroendocrine Tumor:

Name: Laryngeal Neuroendocrine Tumor ¹² ⁵⁸ ¹⁵

Neuroendocrine Neoplasm of Larynx ⁷¹

Laryngeal Neuroendocrine Tumour ¹²

Neuroendocrine Tumour of Larynx ¹²

Neuroendocrine Tumor of Larynx ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Respiratory diseases Neuronal diseases Oral diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare endocrine diseases

External Ids:

Disease Ontology ¹² DOID:5457

NCIt ⁴⁹ C6023

SNOMED-CT ⁶⁷ 707625001

Orphanet ⁵⁸ ORPHA100083

SNOMED-CT via HPO ⁶⁸ 126692004 128928004 161832001 more

UMLS ⁷¹ C1334374

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Summaries for Laryngeal Neuroendocrine Tumor

MalaCards based summary : Laryngeal Neuroendocrine Tumor, also known as neuroendocrine neoplasm of larynx, is related to neuroendocrine tumor and neuroendocrine carcinoma. An important gene associated with Laryngeal Neuroendocrine Tumor is NUTM1 (NUT Midline Carcinoma Family Member 1). Related phenotypes are neuroendocrine neoplasm and neoplasm of the larynx

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Related Diseases for Laryngeal Neuroendocrine Tumor

Diseases related to Laryngeal Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine tumor	29.8	SYP NCAM1 CHGA CALCA
2	neuroendocrine carcinoma	29.8	SYP NCAM1 CHGA CALCA
3	paraganglioma	29.4	SYP NCAM1 CHGA CALCA
4	olfactory neuroblastoma	10.3	SYP CHGA
5	breast neuroendocrine neoplasm	10.3	SYP CHGA
6	pancreatic cholera	10.3	CHGA CALCA
7	primary hepatic neuroendocrine carcinoma	10.3	SYP CHGA
8	small cell carcinoma of the bladder	10.3	SYP CHGA
9	endocrine pancreas disease	10.3	CHGA CALCA
10	acinar cell cystadenocarcinoma	10.3	SYP CHGA
11	vulvar eccrine porocarcinoma	10.3	SYP CHGA
12	cervical large cell neuroendocrine carcinoma	10.3	SYP CHGA
13	gastrointestinal neuroendocrine benign tumor	10.3	SYP CHGA
14	appendix carcinoid tumor	10.3	SYP CHGA
15	auditory system cancer	10.3	SYP CHGA
16	mixed ductal-endocrine carcinoma	10.3	SYP CHGA
17	cauda equina neoplasm	10.3	SYP CHGA
18	duodenal benign neoplasm	10.3	SYP CHGA
19	ampulla of vater neoplasm	10.3	SYP CHGA
20	vaginal tubulovillous adenoma	10.3	SYP CHGA
21	breast papillary carcinoma	10.3	SYP CHGA
22	middle ear adenoma	10.3	SYP CHGA
23	gastric neuroendocrine neoplasm	10.3	SYP CHGA
24	pineocytoma	10.3	SYP CHGA
25	appendix adenocarcinoma	10.3	SYP CHGA
26	pancreatic gastrinoma	10.3	SYP CHGA
27	gastrinoma	10.3	SYP CHGA
28	cervix small cell carcinoma	10.3	SYP CHGA
29	gastrointestinal neuroendocrine tumor	10.3	SYP CHGA
30	carcinoid tumors, intestinal	10.3	SYP CHGA
31	vaginal adenoma	10.3	SYP CHGA
32	endobronchial lipoma	10.3	SYP NUTM1
33	binswanger's disease	10.3	SYP CHGA
34	pancreatic acinar cell adenocarcinoma	10.3	SYP CHGA
35	vaginal benign neoplasm	10.3	SYP CHGA
36	extra-adrenal pheochromocytoma	10.3	SYP CHGA
37	small intestine benign neoplasm	10.3	SYP CHGA
38	horseshoe kidney	10.3	SYP CHGA
39	uterus leiomyosarcoma	10.2	SYP CALCA
40	epithelioid malignant peripheral nerve sheath tumor	10.2	SMARCB1 CHGA
41	adrenal medulla cancer	10.2	SYP CHGA
42	microcystic adenoma	10.2	SYP CHGA
43	pineal region teratoma	10.2	SYP SMARCB1
44	ureter transitional cell carcinoma	10.2	NCAM1 CHGA
45	pulmonary sclerosing hemangioma	10.2	SYP CHGA
46	pancreatoblastoma	10.2	SYP CHGA
47	optic nerve astrocytoma	10.2	SYP SMARCB1
48	somatostatinoma	10.2	CHGA CALCA
49	isthmus cancer	10.2	NCAM1 CALCA
50	solid adenocarcinoma with mucin production	10.2	NCAM1 CHGA

Graphical network of the top 20 diseases related to Laryngeal Neuroendocrine Tumor:

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Symptoms & Phenotypes for Laryngeal Neuroendocrine Tumor

Human phenotypes related to Laryngeal Neuroendocrine Tumor:

⁵⁸ ³¹ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	neuroendocrine neoplasm ⁵⁸ ³¹	obligate (100%)	Obligate (100%)	HP:0100634
2	neoplasm of the larynx ⁵⁸ ³¹	obligate (100%)	Obligate (100%)	HP:0100605
3	weight loss ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001824
4	anorexia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002039
5	chronic fatigue ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0012432
6	dysphonia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001618
7	exertional dyspnea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002875
8	oral-pharyngeal dysphagia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0200136
9	elevated calcitonin ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003528
10	chronic noninfectious lymphadenopathy ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002730
11	increased serum serotonin ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003144
12	adrenocorticotropic hormone excess ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0011749
13	elevated carcinoembryonic antigen level ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0031029
14	inappropriate antidiuretic hormone secretion ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0031218

GenomeRNAi Phenotypes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	SMARCB1 TP53

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Drugs & Therapeutics for Laryngeal Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Laryngeal Neuroendocrine Tumor

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Genetic Tests for Laryngeal Neuroendocrine Tumor

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Anatomical Context for Laryngeal Neuroendocrine Tumor

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Publications for Laryngeal Neuroendocrine Tumor

Articles related to Laryngeal Neuroendocrine Tumor:

#	Title	Authors	PMID	Year
1	Neuroendocrine tumors of the larynx: a clinical report and literature review. ⁶¹	Procopio G...Bajetta E	16683387	2006
2	Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. ⁶¹	Del Gaudio JM...Muller S	14724913	2004

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Genes for Laryngeal Neuroendocrine Tumor

Genes related to Laryngeal Neuroendocrine Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	6.2	DISEASES inferred ¹⁵
2	CHGA	Chromogranin A	Protein Coding	5.49	DISEASES inferred ¹⁵
3	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	4.78	DISEASES inferred ¹⁵
4	SYP	Synaptophysin	Protein Coding	4.42	DISEASES inferred ¹⁵
5	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.22	DISEASES inferred ¹⁵
6	PTCH1	Patched 1	Protein Coding	3.92	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	3.78	DISEASES inferred ¹⁵
8	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	3.69	DISEASES inferred ¹⁵
9	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.43	DISEASES inferred ¹⁵

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Variations for Laryngeal Neuroendocrine Tumor

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Expression for Laryngeal Neuroendocrine Tumor

Search GEO for disease gene expression data for Laryngeal Neuroendocrine Tumor.

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Pathways for Laryngeal Neuroendocrine Tumor

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GO Terms for Laryngeal Neuroendocrine Tumor

Biological processes related to Laryngeal Neuroendocrine Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	commissural neuron axon guidance	GO:0071679	8.62	PTCH1 NCAM1

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