Laryngeal Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Laryngeal Small Cell Carcinoma

MalaCards integrated aliases for Laryngeal Small Cell Carcinoma:

Name: Laryngeal Small Cell Carcinoma ¹² ¹⁵ ¹⁷ ⁷¹

Small Cell Carcinoma of Larynx ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7144

NCIt ⁴⁹ C6025

EFO ¹⁷ EFO_1000320

UMLS ⁷¹ C1334378

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Summaries for Laryngeal Small Cell Carcinoma

MalaCards based summary : Laryngeal Small Cell Carcinoma, also known as small cell carcinoma of larynx, is related to neuroendocrine carcinoma and small cell carcinoma. An important gene associated with Laryngeal Small Cell Carcinoma is CNN1 (Calponin 1), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Neural Stem Cells and Lineage-specific Markers. Related phenotypes are behavior/neurological and mortality/aging

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Related Diseases for Laryngeal Small Cell Carcinoma

Diseases related to Laryngeal Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine carcinoma	27.9	SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
2	small cell carcinoma	27.7	SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
3	paranasal sinus lymphoma	10.4	TAGLN CNN1
4	corneal dystrophy, subepithelial mucinous	10.4	TAGLN CNN1
5	lung meningioma	10.3	SYP NKX2-1
6	anal neuroendocrine tumor	10.3	SYP NCAM1
7	ovarian germ cell teratoma	10.3	SYP NKX2-1
8	lung combined type small cell carcinoma	10.3	SYP NCAM1
9	extraskeletal ewing sarcoma	10.3	SYP NKX2-1
10	hypoganglionosis	10.3	SYP NCAM1
11	glomangiosarcoma	10.3	SYP NCAM1
12	cerebellopontine angle primitive neuroectodermal tumor	10.3	SYP NCAM1
13	subareolar duct papillomatosis	10.3	KRT5 CNN1
14	nipple benign neoplasm	10.3	KRT5 CNN1
15	chordoid glioma	10.3	SYP NKX2-1
16	orbital cancer	10.3	SYP NCAM1
17	vulva basal cell carcinoma	10.2	SYP KRT5
18	eccrine papillary adenocarcinoma	10.2	SYP KRT5
19	ureter adenocarcinoma	10.2	NKX2-1 KRT5
20	thymus basaloid carcinoma	10.2	NKX2-1 KRT5
21	supratentorial primitive neuroectodermal tumor	10.2	SYP NCAM1
22	endobronchial lipoma	10.2	SYP KRT5
23	myxopapillary ependymoma	10.2	SYP NCAM1
24	central epithelioid sarcoma	10.2	SYP KRT5
25	vulvar proximal-type epithelioid sarcoma	10.2	SYP KRT5
26	breast neuroendocrine neoplasm	10.2	SYP CHGA
27	adult astrocytic tumour	10.2	PDGFRA CDKN2A
28	primary hepatic neuroendocrine carcinoma	10.2	SYP CHGA
29	cystic basal cell carcinoma	10.2	SYP KRT5
30	acinar cell cystadenocarcinoma	10.2	SYP CHGA
31	cervical large cell neuroendocrine carcinoma	10.2	SYP CHGA
32	gastrointestinal neuroendocrine benign tumor	10.2	SYP CHGA
33	appendix carcinoid tumor	10.2	SYP CHGA
34	auditory system cancer	10.2	SYP CHGA
35	mixed ductal-endocrine carcinoma	10.2	SYP CHGA
36	cauda equina neoplasm	10.1	SYP CHGA
37	duodenal benign neoplasm	10.1	SYP CHGA
38	ampulla of vater neoplasm	10.1	SYP CHGA
39	mesenchymal chondrosarcoma	10.1	SYP PDGFRA
40	cutaneous adenocystic carcinoma	10.1	NKX2-1 KRT5
41	gastric neuroendocrine neoplasm	10.1	SYP CHGA
42	pineocytoma	10.1	SYP CHGA
43	appendix adenocarcinoma	10.1	SYP CHGA
44	pancreatic gastrinoma	10.1	SYP CHGA
45	cervix small cell carcinoma	10.1	SYP CHGA
46	gastrointestinal neuroendocrine tumor	10.1	SYP CHGA
47	vaginal adenoma	10.1	SYP CHGA
48	carcinoid syndrome	10.1	SYP CHGA
49	binswanger's disease	10.1	SYP CHGA
50	pancreatic acinar cell adenocarcinoma	10.1	SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Small Cell Carcinoma:

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Symptoms & Phenotypes for Laryngeal Small Cell Carcinoma

MGI Mouse Phenotypes related to Laryngeal Small Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.97	CDKN2A KIT KRT5 NCAM1 NKX2-1 PDGFRA
2	mortality/aging	MP:0010768	9.91	CDKN2A CHGA CNN1 KIT KRT5 NCAM1
3	digestive/alimentary	MP:0005381	9.8	CDKN2A KIT KRT5 NKX2-1 PDGFRA TAGLN
4	nervous system	MP:0003631	9.56	CDKN2A CHGA KIT NCAM1 NKX2-1 PDGFRA
5	neoplasm	MP:0002006	9.55	CDKN2A KIT NKX2-1 PDGFRA TAGLN
6	no phenotypic analysis	MP:0003012	9.02	CDKN2A CHGA KIT NKX2-1 PDGFRA

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Drugs & Therapeutics for Laryngeal Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Laryngeal Small Cell Carcinoma

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Genetic Tests for Laryngeal Small Cell Carcinoma

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Anatomical Context for Laryngeal Small Cell Carcinoma

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Publications for Laryngeal Small Cell Carcinoma

Articles related to Laryngeal Small Cell Carcinoma:

#	Title	Authors	PMID	Year
1	Optimal postoperative treatment for composite laryngeal small cell carcinoma. ⁶¹	Ebisumoto K...Iida M	24159397	2013
2	Primary small cell carcinoma of the larynx: report of a rare tumor. ⁶¹	Singh H...Chauhan A	22606450	2011
3	Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature. ⁶¹	Aggarwal G...Sharma S	21228933	2010
4	KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. ⁶¹	Kanazawa T...Iino Y	20537211	2010
5	[Primary laryngeal small cell carcinoma: report of 5 cases]. ⁶¹	Xiao Q...Chen FJ	18510225	2008
6	[Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature]. ⁶¹	Vallejo Valdezate LA...Sanz Santacruz C	12462924	2002
7	Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. ⁶¹	Ferlito A...Pennelli N	3028349	1986
8	Anaplastic small cell carcinoma of larynx. Case report. ⁶¹	Olofsson J...Van Nostrand AW	5027598	1972

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Genes for Laryngeal Small Cell Carcinoma

Genes related to Laryngeal Small Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CNN1	Calponin 1	Protein Coding	6.11	DISEASES inferred ¹⁵
2	TAGLN	Transgelin	Protein Coding	5.64	DISEASES inferred ¹⁵
3	SYP	Synaptophysin	Protein Coding	5.07	DISEASES inferred ¹⁵
4	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	5.06	DISEASES inferred ¹⁵
5	NKX2-1	NK2 Homeobox 1	Protein Coding	4.68	DISEASES inferred ¹⁵
6	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	4.56	DISEASES inferred ¹⁵
7	KRT5	Keratin 5	Protein Coding	4.56	DISEASES inferred ¹⁵
8	CHGA	Chromogranin A	Protein Coding	4.46	DISEASES inferred ¹⁵
9	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	4.33	DISEASES inferred ¹⁵
10	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.7	DISEASES inferred ¹⁵

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Variations for Laryngeal Small Cell Carcinoma

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Expression for Laryngeal Small Cell Carcinoma

Search GEO for disease gene expression data for Laryngeal Small Cell Carcinoma.

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Pathways for Laryngeal Small Cell Carcinoma

Pathways related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.31	NCAM1 KIT CNN1
2	Neural Stem Cells and Lineage-specific Markers ⁶⁴	11.03	SYP PDGFRA NCAM1
3	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	PDGFRA KIT
4	Cardiac Progenitor Differentiation ¹	10.52	PDGFRA NCAM1 KIT

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GO Terms for Laryngeal Small Cell Carcinoma

Cellular components related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mast cell granule	GO:0042629	8.62	KIT CHGA

Biological processes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.4	PDGFRA KIT
2	mast cell degranulation	GO:0043303	9.37	KIT CHGA
3	positive regulation of phospholipase C activity	GO:0010863	9.32	PDGFRA KIT
4	Leydig cell differentiation	GO:0033327	9.26	PDGFRA NKX2-1
5	somatic stem cell division	GO:0048103	9.16	KIT CDKN2A
6	mast cell chemotaxis	GO:0002551	8.96	KIT CHGA
7	mast cell cytokine production	GO:0032762	8.62	KIT CHGA

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Sources for Laryngeal Small Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²⁰ GeneAnalytics

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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³³ ICD10 via Orphanet

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³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

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⁴⁷ NCBI Bookshelf

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⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

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⁶¹ PubMed

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⁶⁹ TGDB

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia