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MCID: LRY005
MIFTS: 27

Laryngeal Small Cell Carcinoma

Categories: Cancer diseases, Oral diseases, Respiratory diseases
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Aliases & Classifications for Laryngeal Small Cell Carcinoma

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MalaCards integrated aliases for Laryngeal Small Cell Carcinoma:

Name: Laryngeal Small Cell Carcinoma 11 14 16 71
Small Cell Carcinoma of Larynx 11

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:7144
NCIt 49 C6025
UMLS 71 C1334378
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Summaries for Laryngeal Small Cell Carcinoma

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MalaCards based summary: Laryngeal Small Cell Carcinoma, also known as small cell carcinoma of larynx, is related to small cell carcinoma and angioedema. An important gene associated with Laryngeal Small Cell Carcinoma is SERPING1 (Serpin Family G Member 1), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cells and Lineage-specific Markers. Related phenotypes are neoplasm and pigmentation
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Related Diseases for Laryngeal Small Cell Carcinoma

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Diseases related to Laryngeal Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.4 SYP NKX2-1 NCAM1 KRT5 CHGA
2 angioedema 30.4 SERPING1 KNG1 C1S
3 angioedema, hereditary, 1 30.4 SERPING1 KNG1 C1S
4 hereditary angioedema 30.3 SERPING1 KNG1 C1S
5 neuroendocrine carcinoma 29.8 SYP NKX2-1 NCAM1 KIT CHGA
6 bladder small cell carcinoma 10.4 SYP NCAM1
7 ovarian mucinous cystadenofibroma 10.4 SYP NCAM1
8 ovarian mucinous adenofibroma 10.4 SYP NCAM1
9 mucinous adenofibroma 10.4 SYP NCAM1
10 anal neuroendocrine tumor 10.4 SYP NCAM1
11 louse-borne relapsing fever 10.4 SERPING1 C1S
12 cerebellopontine angle primitive neuroectodermal tumor 10.4 SYP NCAM1
13 cerebral neuroblastoma 10.4 SYP CHGA
14 thymus small cell carcinoma 10.4 SYP CHGA
15 breast neuroendocrine neoplasm 10.4 SYP CHGA
16 pancreas lymphoma 10.4 SYP CHGA
17 vaginal tubulovillous adenoma 10.3 SYP CHGA
18 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
19 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
20 cauda equina neoplasm 10.3 SYP CHGA
21 colon neuroendocrine neoplasm 10.3 SYP CHGA
22 duodenal benign neoplasm 10.3 SYP CHGA
23 ampulla of vater benign neoplasm 10.3 SYP CHGA
24 acinar cell cystadenocarcinoma 10.3 SYP CHGA
25 pineal region choriocarcinoma 10.3 SYP CHGA
26 auditory system cancer 10.3 SYP CHGA
27 gastric gastrinoma 10.3 SYP CHGA
28 nodular ganglioneuroblastoma 10.3 SYP CHGA
29 pineocytoma 10.3 SYP CHGA
30 appendix carcinoid tumor 10.3 SYP CHGA
31 allergic urticaria 10.3 SERPING1 KNG1
32 lung meningioma 10.3 SYP NKX2-1
33 ectopic cushing syndrome 10.3 SYP CHGA
34 binswanger's disease 10.3 SYP CHGA
35 sternum lymphoma 10.3 NKX2-1 NCAM1
36 sternum cancer 10.3 NKX2-1 NCAM1
37 duodenal gastrinoma 10.3 SYP CHGA
38 chronic inducible urticaria 10.3 SERPING1 KNG1
39 extra-adrenal pheochromocytoma 10.3 SYP CHGA
40 dermatographia 10.3 SERPING1 KNG1
41 carcinoid syndrome 10.3 SYP CHGA
42 lung combined large cell neuroendocrine carcinoma 10.3 SYP CHGA
43 adrenal neuroblastoma 10.3 SYP CHGA
44 pancreatic gastrinoma 10.3 SYP CHGA
45 orbital cancer 10.3 SYP NCAM1
46 cholinergic urticaria 10.3 SERPING1 KNG1
47 benign ileal neoplasm 10.3 SYP CHGA
48 prostatic urethral cancer 10.3 NCAM1 KRT5
49 cloacogenic carcinoma 10.3 SYP KRT5
50 rectum squamous cell carcinoma 10.3 SYP KRT5

Graphical network of the top 20 diseases related to Laryngeal Small Cell Carcinoma:



Diseases related to Laryngeal Small Cell Carcinoma
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Symptoms & Phenotypes for Laryngeal Small Cell Carcinoma

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GenomeRNAi Phenotypes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 C1S CDKN2A CHGA KIT KITLG KNG1
2 no effect GR00402-S-2 10.17 C1S CDKN2A CHGA KIT KITLG KNG1

MGI Mouse Phenotypes related to Laryngeal Small Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.76 CDKN2A KIT KITLG KRT14 NKX2-1 PDGFRA
2 pigmentation MP:0001186 9.73 CDKN2A KIT KITLG KRT14 MLANA PDGFRA
3 endocrine/exocrine gland MP:0005379 9.61 CDKN2A CHGA KIT KITLG KRT14 NKX2-1
4 digestive/alimentary MP:0005381 9.23 CDKN2A KIT KITLG KRT14 KRT5 NKX2-1
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Drugs & Therapeutics for Laryngeal Small Cell Carcinoma

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Search Clinical Trials, NIH Clinical Center for Laryngeal Small Cell Carcinoma

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Genetic Tests for Laryngeal Small Cell Carcinoma

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Anatomical Context for Laryngeal Small Cell Carcinoma

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Publications for Laryngeal Small Cell Carcinoma

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Articles related to Laryngeal Small Cell Carcinoma:

# Title Authors PMID Year
1
Sore Throat: Can It Be Primary Laryngeal Small Cell Carcinoma? 62
35464591 2022
2
Concurrent Paraneoplastic Dermatomyositis and Acquired C1 Esterase Inhibitor Deficiency in Primary Laryngeal Small Cell Carcinoma. 62
35111013 2021
3
Optimal postoperative treatment for composite laryngeal small cell carcinoma. 62
24159397 2013
4
Primary small cell carcinoma of the larynx: report of a rare tumor. 62
22606450 2011
5
KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. 62
20537211 2010
6
Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature. 62
21228933 2010
7
[Primary laryngeal small cell carcinoma: report of 5 cases]. 62
18510225 2008
8
[Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature]. 62
12462924 2002
9
Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. 62
3028349 1986
10
Anaplastic small cell carcinoma of larynx. Case report. 62
5027598 1972
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Variations for Laryngeal Small Cell Carcinoma

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Expression for Laryngeal Small Cell Carcinoma

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Search GEO for disease gene expression data for Laryngeal Small Cell Carcinoma.
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Pathways for Laryngeal Small Cell Carcinoma

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Pathways related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 3
12.27 SYP PSIP1 NKX2-1 NCAM1
2
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.64 NCAM1 KITLG KIT
3
Gastrin signaling pathway 74
11.59 KIT CHGA CDKN2A
4
NF-kappaB Signaling 3
11.54 PSIP1 NCAM1 MLANA KITLG KIT
5
C-MYB transcription factor network 61
11.4 KITLG KIT CDKN2A
6
Neural Stem Cells and Lineage-specific Markers 65
11.33 SYP PDGFRA NCAM1
7
Cardiac progenitor differentiation 74
11.06 PDGFRA NCAM1 KIT
8
Validated transcriptional targets of deltaNp63 isoforms 61
10.8 KRT5 KRT14 CDKN2A
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GO Terms for Laryngeal Small Cell Carcinoma

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Biological processes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mast cell proliferation GO:0070668 9.56 KITLG KIT
2 mast cell proliferation GO:0070662 9.46 KITLG KIT
3 mast cell chemotaxis GO:0002551 9.26 KIT CHGA
4 melanocyte migration GO:0097324 8.92 KITLG KIT
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Sources for Laryngeal Small Cell Carcinoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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