MCID: LRY005
MIFTS: 26

Laryngeal Small Cell Carcinoma

Categories: Cancer diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Small Cell Carcinoma

MalaCards integrated aliases for Laryngeal Small Cell Carcinoma:

Name: Laryngeal Small Cell Carcinoma 12 15 17 71
Small Cell Carcinoma of Larynx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7144
NCIt 50 C6025
UMLS 71 C1334378

Summaries for Laryngeal Small Cell Carcinoma

MalaCards based summary : Laryngeal Small Cell Carcinoma, also known as small cell carcinoma of larynx, is related to neuroendocrine carcinoma and small cell carcinoma. An important gene associated with Laryngeal Small Cell Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Pazopanib Pathway, Pharmacokinetics. Related phenotypes are behavior/neurological and digestive/alimentary

Related Diseases for Laryngeal Small Cell Carcinoma

Diseases related to Laryngeal Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 28.6 SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
2 small cell carcinoma 28.5 SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
3 lung meningioma 10.3 SYP NKX2-1
4 ureteral benign neoplasm 10.2 SYP NKX2-1
5 ovarian germ cell teratoma 10.2 SYP NKX2-1
6 cloacogenic carcinoma 10.2 SYP KRT5
7 chordoid glioma 10.2 SYP NKX2-1
8 ovarian germ cell cancer 10.2 SYP NKX2-1
9 endobronchial lipoma 10.2 SYP KRT5
10 anal neuroendocrine tumor 10.2 SYP NCAM1
11 cystic basal cell carcinoma 10.2 SYP KRT5
12 ureter adenocarcinoma 10.2 NKX2-1 KRT5
13 central epithelioid sarcoma 10.2 SYP KRT5
14 lung combined type small cell carcinoma 10.2 SYP NCAM1
15 vulvar proximal-type epithelioid sarcoma 10.2 SYP KRT5
16 hypoganglionosis 10.2 SYP NCAM1
17 glomangiosarcoma 10.2 SYP NCAM1
18 cerebellopontine angle primitive neuroectodermal tumor 10.2 SYP NCAM1
19 orbital cancer 10.2 SYP NCAM1
20 biliary tract benign neoplasm 10.2 SYP NCAM1
21 cutaneous adenocystic carcinoma 10.2 NKX2-1 KRT5
22 extraosseous ewing sarcoma 10.2 SYP NCAM1
23 mesenchymal chondrosarcoma 10.2 SYP PDGFRA
24 nasal cavity adenocarcinoma 10.1 SYP CDKN2A
25 adult astrocytic tumour 10.1 PDGFRA CDKN2A
26 penile urethral cancer 10.1 KRT5 CDKN2A
27 primary hepatic neuroendocrine carcinoma 10.1 SYP CHGA
28 auditory system cancer 10.1 SYP CHGA
29 adenomatoid tumor 10.1 NKX2-1 KRT5
30 acinar cell cystadenocarcinoma 10.1 SYP CHGA
31 male urethral cancer 10.1 KRT5 CDKN2A
32 inverted transitional papilloma 10.1 KRT5 CDKN2A
33 cauda equina neoplasm 10.1 SYP CHGA
34 gastrointestinal neuroendocrine benign tumor 10.1 SYP CHGA
35 ampulla of vater neoplasm 10.1 SYP CHGA
36 appendix carcinoid tumor 10.1 SYP CHGA
37 mixed ductal-endocrine carcinoma 10.1 SYP CHGA
38 middle ear adenoma 10.1 SYP CHGA
39 duodenal benign neoplasm 10.1 SYP CHGA
40 sweat gland cancer 10.1 SYP KRT5
41 cellular ependymoma 10.1 SYP NCAM1
42 myxopapillary ependymoma 10.1 SYP NCAM1
43 gastric neuroendocrine neoplasm 10.1 SYP CHGA
44 appendix adenocarcinoma 10.1 SYP CHGA
45 supratentorial primitive neuroectodermal tumor 10.1 SYP NCAM1
46 pineocytoma 10.1 SYP CHGA
47 pancreatic gastrinoma 10.1 SYP CHGA
48 cervix small cell carcinoma 10.1 SYP CHGA
49 adrenal neuroblastoma 10.1 SYP CHGA
50 gastrointestinal neuroendocrine tumor 10.1 SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Small Cell Carcinoma:



Diseases related to Laryngeal Small Cell Carcinoma

Symptoms & Phenotypes for Laryngeal Small Cell Carcinoma

MGI Mouse Phenotypes related to Laryngeal Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CDKN2A KIT KRT5 NCAM1 NKX2-1 PDGFRA
2 digestive/alimentary MP:0005381 9.55 CDKN2A KIT KRT5 NKX2-1 PDGFRA
3 nervous system MP:0003631 9.5 CDKN2A CHGA KIT NCAM1 NKX2-1 PDGFRA
4 no phenotypic analysis MP:0003012 9.02 CDKN2A CHGA KIT NKX2-1 PDGFRA

Drugs & Therapeutics for Laryngeal Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Laryngeal Small Cell Carcinoma

Genetic Tests for Laryngeal Small Cell Carcinoma

Anatomical Context for Laryngeal Small Cell Carcinoma

Publications for Laryngeal Small Cell Carcinoma

Articles related to Laryngeal Small Cell Carcinoma:

# Title Authors PMID Year
1
Optimal postoperative treatment for composite laryngeal small cell carcinoma. 61
24159397 2013
2
Primary small cell carcinoma of the larynx: report of a rare tumor. 61
22606450 2011
3
KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. 61
20537211 2010
4
Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature. 61
21228933 2010
5
[Primary laryngeal small cell carcinoma: report of 5 cases]. 61
18510225 2008
6
[Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature]. 61
12462924 2002
7
Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. 61
3028349 1986
8
Anaplastic small cell carcinoma of larynx. Case report. 61
5027598 1972

Variations for Laryngeal Small Cell Carcinoma

Expression for Laryngeal Small Cell Carcinoma

Search GEO for disease gene expression data for Laryngeal Small Cell Carcinoma.

Pathways for Laryngeal Small Cell Carcinoma

Pathways related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 SYP PDGFRA NCAM1
2
Show member pathways
10.69 PDGFRA KIT
3 10.52 PDGFRA NCAM1 KIT

GO Terms for Laryngeal Small Cell Carcinoma

Biological processes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.61 PDGFRA NCAM1 KIT
2 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.4 PDGFRA KIT
3 mast cell degranulation GO:0043303 9.37 KIT CHGA
4 positive regulation of phospholipase C activity GO:0010863 9.32 PDGFRA KIT
5 Leydig cell differentiation GO:0033327 9.26 PDGFRA NKX2-1
6 somatic stem cell division GO:0048103 9.16 KIT CDKN2A
7 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
8 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Molecular functions related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SH2 domain binding GO:0042169 8.62 SYP KIT

Sources for Laryngeal Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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