MCID: LRY005
MIFTS: 26

Laryngeal Small Cell Carcinoma

Categories: Cancer diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngeal Small Cell Carcinoma

MalaCards integrated aliases for Laryngeal Small Cell Carcinoma:

Name: Laryngeal Small Cell Carcinoma 12 15 17 71
Small Cell Carcinoma of Larynx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7144
NCIt 49 C6025
UMLS 71 C1334378

Summaries for Laryngeal Small Cell Carcinoma

MalaCards based summary : Laryngeal Small Cell Carcinoma, also known as small cell carcinoma of larynx, is related to neuroendocrine carcinoma and small cell carcinoma. An important gene associated with Laryngeal Small Cell Carcinoma is CNN1 (Calponin 1), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Neural Stem Cells and Lineage-specific Markers. Related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Laryngeal Small Cell Carcinoma

Diseases related to Laryngeal Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 27.9 SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
2 small cell carcinoma 27.7 SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
3 paranasal sinus lymphoma 10.4 TAGLN CNN1
4 corneal dystrophy, subepithelial mucinous 10.4 TAGLN CNN1
5 lung meningioma 10.3 SYP NKX2-1
6 anal neuroendocrine tumor 10.3 SYP NCAM1
7 ovarian germ cell teratoma 10.3 SYP NKX2-1
8 lung combined type small cell carcinoma 10.3 SYP NCAM1
9 extraskeletal ewing sarcoma 10.3 SYP NKX2-1
10 hypoganglionosis 10.3 SYP NCAM1
11 glomangiosarcoma 10.3 SYP NCAM1
12 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP NCAM1
13 subareolar duct papillomatosis 10.3 KRT5 CNN1
14 nipple benign neoplasm 10.3 KRT5 CNN1
15 chordoid glioma 10.3 SYP NKX2-1
16 orbital cancer 10.3 SYP NCAM1
17 vulva basal cell carcinoma 10.2 SYP KRT5
18 eccrine papillary adenocarcinoma 10.2 SYP KRT5
19 ureter adenocarcinoma 10.2 NKX2-1 KRT5
20 thymus basaloid carcinoma 10.2 NKX2-1 KRT5
21 supratentorial primitive neuroectodermal tumor 10.2 SYP NCAM1
22 endobronchial lipoma 10.2 SYP KRT5
23 myxopapillary ependymoma 10.2 SYP NCAM1
24 central epithelioid sarcoma 10.2 SYP KRT5
25 vulvar proximal-type epithelioid sarcoma 10.2 SYP KRT5
26 breast neuroendocrine neoplasm 10.2 SYP CHGA
27 adult astrocytic tumour 10.2 PDGFRA CDKN2A
28 primary hepatic neuroendocrine carcinoma 10.2 SYP CHGA
29 cystic basal cell carcinoma 10.2 SYP KRT5
30 acinar cell cystadenocarcinoma 10.2 SYP CHGA
31 cervical large cell neuroendocrine carcinoma 10.2 SYP CHGA
32 gastrointestinal neuroendocrine benign tumor 10.2 SYP CHGA
33 appendix carcinoid tumor 10.2 SYP CHGA
34 auditory system cancer 10.2 SYP CHGA
35 mixed ductal-endocrine carcinoma 10.2 SYP CHGA
36 cauda equina neoplasm 10.1 SYP CHGA
37 duodenal benign neoplasm 10.1 SYP CHGA
38 ampulla of vater neoplasm 10.1 SYP CHGA
39 mesenchymal chondrosarcoma 10.1 SYP PDGFRA
40 cutaneous adenocystic carcinoma 10.1 NKX2-1 KRT5
41 gastric neuroendocrine neoplasm 10.1 SYP CHGA
42 pineocytoma 10.1 SYP CHGA
43 appendix adenocarcinoma 10.1 SYP CHGA
44 pancreatic gastrinoma 10.1 SYP CHGA
45 cervix small cell carcinoma 10.1 SYP CHGA
46 gastrointestinal neuroendocrine tumor 10.1 SYP CHGA
47 vaginal adenoma 10.1 SYP CHGA
48 carcinoid syndrome 10.1 SYP CHGA
49 binswanger's disease 10.1 SYP CHGA
50 pancreatic acinar cell adenocarcinoma 10.1 SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Small Cell Carcinoma:



Diseases related to Laryngeal Small Cell Carcinoma

Symptoms & Phenotypes for Laryngeal Small Cell Carcinoma

MGI Mouse Phenotypes related to Laryngeal Small Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 CDKN2A KIT KRT5 NCAM1 NKX2-1 PDGFRA
2 mortality/aging MP:0010768 9.91 CDKN2A CHGA CNN1 KIT KRT5 NCAM1
3 digestive/alimentary MP:0005381 9.8 CDKN2A KIT KRT5 NKX2-1 PDGFRA TAGLN
4 nervous system MP:0003631 9.56 CDKN2A CHGA KIT NCAM1 NKX2-1 PDGFRA
5 neoplasm MP:0002006 9.55 CDKN2A KIT NKX2-1 PDGFRA TAGLN
6 no phenotypic analysis MP:0003012 9.02 CDKN2A CHGA KIT NKX2-1 PDGFRA

Drugs & Therapeutics for Laryngeal Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Laryngeal Small Cell Carcinoma

Genetic Tests for Laryngeal Small Cell Carcinoma

Anatomical Context for Laryngeal Small Cell Carcinoma

Publications for Laryngeal Small Cell Carcinoma

Articles related to Laryngeal Small Cell Carcinoma:

# Title Authors PMID Year
1
Optimal postoperative treatment for composite laryngeal small cell carcinoma. 61
24159397 2013
2
Primary small cell carcinoma of the larynx: report of a rare tumor. 61
22606450 2011
3
Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature. 61
21228933 2010
4
KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. 61
20537211 2010
5
[Primary laryngeal small cell carcinoma: report of 5 cases]. 61
18510225 2008
6
[Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature]. 61
12462924 2002
7
Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. 61
3028349 1986
8
Anaplastic small cell carcinoma of larynx. Case report. 61
5027598 1972

Variations for Laryngeal Small Cell Carcinoma

Expression for Laryngeal Small Cell Carcinoma

Search GEO for disease gene expression data for Laryngeal Small Cell Carcinoma.

Pathways for Laryngeal Small Cell Carcinoma

Pathways related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.31 NCAM1 KIT CNN1
2 11.03 SYP PDGFRA NCAM1
3
Show member pathways
10.79 PDGFRA KIT
4 10.52 PDGFRA NCAM1 KIT

GO Terms for Laryngeal Small Cell Carcinoma

Cellular components related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.62 KIT CHGA

Biological processes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.4 PDGFRA KIT
2 mast cell degranulation GO:0043303 9.37 KIT CHGA
3 positive regulation of phospholipase C activity GO:0010863 9.32 PDGFRA KIT
4 Leydig cell differentiation GO:0033327 9.26 PDGFRA NKX2-1
5 somatic stem cell division GO:0048103 9.16 KIT CDKN2A
6 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
7 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Laryngeal Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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