Laryngeal Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Laryngeal Small Cell Carcinoma

MalaCards integrated aliases for Laryngeal Small Cell Carcinoma:

Name: Laryngeal Small Cell Carcinoma ¹² ¹⁵ ¹⁷ ⁷¹

Small Cell Carcinoma of Larynx ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7144

NCIt ⁵⁰ C6025

EFO ¹⁷ EFO_1000320

UMLS ⁷¹ C1334378

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Summaries for Laryngeal Small Cell Carcinoma

MalaCards based summary : Laryngeal Small Cell Carcinoma, also known as small cell carcinoma of larynx, is related to neuroendocrine carcinoma and small cell carcinoma. An important gene associated with Laryngeal Small Cell Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Pazopanib Pathway, Pharmacokinetics. Related phenotypes are behavior/neurological and digestive/alimentary

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Related Diseases for Laryngeal Small Cell Carcinoma

Diseases related to Laryngeal Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine carcinoma	28.6	SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
2	small cell carcinoma	28.5	SYP PDGFRA NKX2-1 NCAM1 KIT CHGA
3	lung meningioma	10.3	SYP NKX2-1
4	ureteral benign neoplasm	10.2	SYP NKX2-1
5	ovarian germ cell teratoma	10.2	SYP NKX2-1
6	cloacogenic carcinoma	10.2	SYP KRT5
7	chordoid glioma	10.2	SYP NKX2-1
8	ovarian germ cell cancer	10.2	SYP NKX2-1
9	endobronchial lipoma	10.2	SYP KRT5
10	anal neuroendocrine tumor	10.2	SYP NCAM1
11	cystic basal cell carcinoma	10.2	SYP KRT5
12	ureter adenocarcinoma	10.2	NKX2-1 KRT5
13	central epithelioid sarcoma	10.2	SYP KRT5
14	lung combined type small cell carcinoma	10.2	SYP NCAM1
15	vulvar proximal-type epithelioid sarcoma	10.2	SYP KRT5
16	hypoganglionosis	10.2	SYP NCAM1
17	glomangiosarcoma	10.2	SYP NCAM1
18	cerebellopontine angle primitive neuroectodermal tumor	10.2	SYP NCAM1
19	orbital cancer	10.2	SYP NCAM1
20	biliary tract benign neoplasm	10.2	SYP NCAM1
21	cutaneous adenocystic carcinoma	10.2	NKX2-1 KRT5
22	extraosseous ewing sarcoma	10.2	SYP NCAM1
23	mesenchymal chondrosarcoma	10.2	SYP PDGFRA
24	nasal cavity adenocarcinoma	10.1	SYP CDKN2A
25	adult astrocytic tumour	10.1	PDGFRA CDKN2A
26	penile urethral cancer	10.1	KRT5 CDKN2A
27	primary hepatic neuroendocrine carcinoma	10.1	SYP CHGA
28	auditory system cancer	10.1	SYP CHGA
29	adenomatoid tumor	10.1	NKX2-1 KRT5
30	acinar cell cystadenocarcinoma	10.1	SYP CHGA
31	male urethral cancer	10.1	KRT5 CDKN2A
32	inverted transitional papilloma	10.1	KRT5 CDKN2A
33	cauda equina neoplasm	10.1	SYP CHGA
34	gastrointestinal neuroendocrine benign tumor	10.1	SYP CHGA
35	ampulla of vater neoplasm	10.1	SYP CHGA
36	appendix carcinoid tumor	10.1	SYP CHGA
37	mixed ductal-endocrine carcinoma	10.1	SYP CHGA
38	middle ear adenoma	10.1	SYP CHGA
39	duodenal benign neoplasm	10.1	SYP CHGA
40	sweat gland cancer	10.1	SYP KRT5
41	cellular ependymoma	10.1	SYP NCAM1
42	myxopapillary ependymoma	10.1	SYP NCAM1
43	gastric neuroendocrine neoplasm	10.1	SYP CHGA
44	appendix adenocarcinoma	10.1	SYP CHGA
45	supratentorial primitive neuroectodermal tumor	10.1	SYP NCAM1
46	pineocytoma	10.1	SYP CHGA
47	pancreatic gastrinoma	10.1	SYP CHGA
48	cervix small cell carcinoma	10.1	SYP CHGA
49	adrenal neuroblastoma	10.1	SYP CHGA
50	gastrointestinal neuroendocrine tumor	10.1	SYP CHGA

Graphical network of the top 20 diseases related to Laryngeal Small Cell Carcinoma:

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Symptoms & Phenotypes for Laryngeal Small Cell Carcinoma

MGI Mouse Phenotypes related to Laryngeal Small Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.8	CDKN2A KIT KRT5 NCAM1 NKX2-1 PDGFRA
2	digestive/alimentary	MP:0005381	9.55	CDKN2A KIT KRT5 NKX2-1 PDGFRA
3	nervous system	MP:0003631	9.5	CDKN2A CHGA KIT NCAM1 NKX2-1 PDGFRA
4	no phenotypic analysis	MP:0003012	9.02	CDKN2A CHGA KIT NKX2-1 PDGFRA

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Drugs & Therapeutics for Laryngeal Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Laryngeal Small Cell Carcinoma

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Genetic Tests for Laryngeal Small Cell Carcinoma

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Anatomical Context for Laryngeal Small Cell Carcinoma

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Publications for Laryngeal Small Cell Carcinoma

Articles related to Laryngeal Small Cell Carcinoma:

#	Title	Authors	PMID	Year
1	Optimal postoperative treatment for composite laryngeal small cell carcinoma. ⁶¹	Ebisumoto K...Iida M	24159397	2013
2	Primary small cell carcinoma of the larynx: report of a rare tumor. ⁶¹	Singh H...Chauhan A	22606450	2011
3	KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. ⁶¹	Kanazawa T...Iino Y	20537211	2010
4	Primary combined small cell carcinoma of larynx with lateralized histologic components and corresponding side-specific neck nodal metastasis: report of a unique case and review of literature. ⁶¹	Aggarwal G...Sharma S	21228933	2010
5	[Primary laryngeal small cell carcinoma: report of 5 cases]. ⁶¹	Xiao Q...Chen FJ	18510225	2008
6	[Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature]. ⁶¹	Vallejo Valdezate LA...Sanz Santacruz C	12462924	2002
7	Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. ⁶¹	Ferlito A...Pennelli N	3028349	1986
8	Anaplastic small cell carcinoma of larynx. Case report. ⁶¹	Olofsson J...Van Nostrand AW	5027598	1972

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Genes for Laryngeal Small Cell Carcinoma

Genes related to Laryngeal Small Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYP	Synaptophysin	Protein Coding	5.1	DISEASES inferred ¹⁵
2	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	5.08	DISEASES inferred ¹⁵
3	NKX2-1	NK2 Homeobox 1	Protein Coding	4.71	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	4.59	DISEASES inferred ¹⁵
5	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	4.59	DISEASES inferred ¹⁵
6	CHGA	Chromogranin A	Protein Coding	4.5	DISEASES inferred ¹⁵
7	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	4.38	DISEASES inferred ¹⁵
8	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.74	DISEASES inferred ¹⁵

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Variations for Laryngeal Small Cell Carcinoma

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Expression for Laryngeal Small Cell Carcinoma

Search GEO for disease gene expression data for Laryngeal Small Cell Carcinoma.

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Pathways for Laryngeal Small Cell Carcinoma

Pathways related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.03	SYP PDGFRA NCAM1
2	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.69	PDGFRA KIT
3	Cardiac Progenitor Differentiation ¹	10.52	PDGFRA NCAM1 KIT

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GO Terms for Laryngeal Small Cell Carcinoma

Biological processes related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MAPK cascade	GO:0000165	9.61	PDGFRA NCAM1 KIT
2	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.4	PDGFRA KIT
3	mast cell degranulation	GO:0043303	9.37	KIT CHGA
4	positive regulation of phospholipase C activity	GO:0010863	9.32	PDGFRA KIT
5	Leydig cell differentiation	GO:0033327	9.26	PDGFRA NKX2-1
6	somatic stem cell division	GO:0048103	9.16	KIT CDKN2A
7	mast cell chemotaxis	GO:0002551	8.96	KIT CHGA
8	mast cell cytokine production	GO:0032762	8.62	KIT CHGA

Molecular functions related to Laryngeal Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	SH2 domain binding	GO:0042169	8.62	SYP KIT

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Sources for Laryngeal Small Cell Carcinoma

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