MCID: LRY007
MIFTS: 34

Laryngeal Tuberculosis

Categories: Respiratory diseases

Aliases & Classifications for Laryngeal Tuberculosis

MalaCards integrated aliases for Laryngeal Tuberculosis:

Name: Laryngeal Tuberculosis 12 15
Tuberculosis, Laryngeal 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1583
ICD10 33 A15.5
ICD9CM 35 012.3
MeSH 44 D014387
NCIt 50 C26895
SNOMED-CT 68 70341005
UMLS 73 C0041315

Summaries for Laryngeal Tuberculosis

Disease Ontology : 12 A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

MalaCards based summary : Laryngeal Tuberculosis, also known as tuberculosis, laryngeal, is related to laryngitis and fungal esophagitis. An important gene associated with Laryngeal Tuberculosis is SLC25A46 (Solute Carrier Family 25 Member 46). The drugs Isoniazid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include trachea, tongue and lung, and related phenotypes are Increased viability with TRAIL and renal/urinary system

Related Diseases for Laryngeal Tuberculosis

Diseases related to Laryngeal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 laryngitis 31.7 ATP12A ATP4A
2 fungal esophagitis 10.5 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.5 ATP12A ATP4A
4 microscopic colitis 10.5 ATP12A LYZ
5 neonatal candidiasis 10.5 ATP12A ATP4A
6 photoallergic dermatitis 10.5 ATP12A ATP4A
7 squamous papillomatosis 10.5 ATP12A ATP4A
8 acute laryngitis 10.5 ATP12A ATP4A
9 gastroduodenal crohn's disease 10.5 ATP12A ATP4A
10 gastric neuroendocrine neoplasm 10.5 ATP12A ATP4A
11 toxic megacolon 10.5 ATP12A ATP4A
12 aspiration pneumonitis 10.5 ATP12A ATP4A
13 postsurgical hypothyroidism 10.5 ATP12A ATP4A
14 gastric antral vascular ectasia 10.5 ATP12A ATP4A
15 suprasellar meningioma 10.5 CDK9 POMC
16 esophageal candidiasis 10.5 ATP12A ATP4A
17 duodenitis 10.5 ATP12A ATP4A
18 rumination disorder 10.5 ATP12A ATP4A
19 bile reflux 10.5 ATP12A ATP4A
20 granulomatous gastritis 10.5 ATP12A ATP4A
21 active peptic ulcer disease 10.5 ATP12A ATP4A
22 ischemic neuropathy 10.5 ATP12A ATP4A
23 capillary disease 10.5 ATP12A ATP4A
24 peptic esophagitis 10.5 ATP12A ATP4A
25 duodenal disease 10.5 ATP12A ATP4A
26 dyskinesia of esophagus 10.5 ATP12A ATP4A
27 hernia, hiatus 10.5 ATP12A ATP4A
28 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.4 ATP12A ATP4A
30 lymphocytic colitis 10.4 ATP12A ATP4A
31 clostridium difficile colitis 10.4 ATP12A ATP4A
32 lower urinary tract calculus 10.4 ATP12A ATP4A
33 aspiration pneumonia 10.4 ATP12A ATP4A
34 diarrhea 1, secretory chloride, congenital 10.4 ATP12A ATP4A
35 eosinophilic gastritis 10.4 ATP12A ATP4A
36 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP12A ATP4A
37 esophageal varix 10.4 ATP12A ATP4A
38 esophagus adenocarcinoma 10.4 ATP12A ATP4A
39 cutaneous solitary mastocytoma 10.4 LYZ POMC
40 gastric lymphoma 10.4 ATP12A ATP4A
41 pancreatic steatorrhea 10.4 ATP12A ATP4A
42 pneumatosis cystoides intestinalis 10.4 ATP12A ATP4A
43 superior mesenteric artery syndrome 10.4 ATP12A ATP4A
44 jejunoileitis 10.4 ATP12A ATP4A
45 functional gastric disease 10.3 ATP12A ATP4A
46 functional colonic disease 10.3 CD59 KANTR
47 paine syndrome 10.3 ATP12A ATP4A
48 esophagitis, eosinophilic, 1 10.3 ATP12A ATP4A
49 central nervous system vasculitis 10.3 CDK9 SMUG1
50 granulomatous myositis 10.3 LYZ SMUG1

Graphical network of the top 20 diseases related to Laryngeal Tuberculosis:



Diseases related to Laryngeal Tuberculosis

Symptoms & Phenotypes for Laryngeal Tuberculosis

GenomeRNAi Phenotypes related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with TRAIL GR00154-A 8.62 CDK9 GNE

MGI Mouse Phenotypes related to Laryngeal Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 ATP12A CD59 GNE LYZ POMC

Drugs & Therapeutics for Laryngeal Tuberculosis

Drugs for Laryngeal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Antimetabolites Phase 4
5 Antitubercular Agents Phase 4
6 Hypolipidemic Agents Phase 4
7 Interferon-gamma Phase 4
8 interferons Phase 4
9 Lipid Regulating Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 QuantiFERON®-TB Gold In-Tube for the Diagnosis of Tuberculosis Infection in Contact Tracing Study. Completed NCT01223534 Phase 4 Preventive treatment with Isoniazid.;Preventive treatment with Isoniazid

Search NIH Clinical Center for Laryngeal Tuberculosis

Cochrane evidence based reviews: tuberculosis, laryngeal

Genetic Tests for Laryngeal Tuberculosis

Anatomical Context for Laryngeal Tuberculosis

MalaCards organs/tissues related to Laryngeal Tuberculosis:

41
Trachea, Tongue, Lung

Publications for Laryngeal Tuberculosis

Articles related to Laryngeal Tuberculosis:

(show top 50) (show all 152)
# Title Authors Year
1
Primary Laryngeal Tuberculosis: Our Experiences at a Tertiary Care Teaching Hospital in Eastern India. ( 29773323 )
2018
2
Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. ( 29017739 )
2018
3
Laryngeal tuberculosis: a rare cause of critical airway obstruction. ( 29348284 )
2018
4
Laryngeal Tuberculosis Mimicking Laryngeal Carcinoma on <sup>18</sup>F-FDG PET/CT Imaging. ( 29889030 )
2018
5
Laryngeal tuberculosis: a forgotten disease. ( 28383648 )
2017
6
'A most malignant malady': a rare case of laryngeal tuberculosis in epidermal growth factor receptor mutant lung adenocarcinoma. ( 28994257 )
2017
7
Rigid laryngoscope manifestations of 61 cases of modern laryngeal tuberculosis. ( 29201220 )
2017
8
Tracheobronchopathia osteochondroplastica following laryngeal tuberculosis. ( 28869241 )
2017
9
Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis. ( 27077734 )
2016
10
Dysphonia - the single symptom of rifampicin resistant laryngeal tuberculosis. ( 28352769 )
2016
11
Palatopharyngoplasty for treatment of nasopharyngeal stenosis secondary to extra-laryngeal tuberculosis. ( 27448412 )
2016
12
Secondary laryngeal tuberculosis revisited. ( 26628760 )
2015
13
Laryngeal tuberculosis: A public health concern. ( 26535835 )
2015
14
Laryngeal tuberculosis: A report of 17 cases. ( 25748515 )
2015
15
Laryngeal tuberculosis diagnosed by stool sample cultures: a case report. ( 25886183 )
2015
16
Evaluation of voice disorders in patients with active laryngeal tuberculosis. ( 26009888 )
2015
17
Laryngeal tuberculosis: use of videostroboscopy in diagnosis. ( 24526475 )
2014
18
Laryngeal tuberculosis: A diagnosis not to be overlooked. ( 25284447 )
2014
19
Primary laryngeal tuberculosis: An unusual cause of hoarseness. ( 25397382 )
2014
20
Laryngeal tuberculosis in the United States of America: a forgotten disease. ( 24628484 )
2014
21
Interferon-I^ release assay in the diagnosis of laryngeal tuberculosis. ( 24256035 )
2013
22
Clinical features of laryngeal tuberculosis in iran. ( 24338196 )
2013
23
Laryngeal tuberculosis: a diagnosis that should be remembered. ( 23037489 )
2012
24
Atypical presentation of laryngeal tuberculosis in a pediatric patient. ( 22398120 )
2012
25
Laryngeal tuberculosis: A case of a non-healing laryngeal lesion. ( 22952563 )
2012
26
Laryngeal tuberculosis without pulmonary involvement. ( 26557293 )
2012
27
Laryngeal tuberculosis presenting as laryngeal carcinoma. ( 22755382 )
2012
28
Primary laryngeal tuberculosis. ( 22248835 )
2011
29
Primary laryngeal tuberculosis--a rare entity. ( 21043358 )
2010
30
Vocal quality of patients treated for laryngeal tuberculosis, before and after speech therapy. ( 20843405 )
2010
31
Primary laryngeal tuberculosis mimicking laryngeal carcinoma: CT scan features. ( 20351985 )
2010
32
Changing trends in the clinical features of laryngeal tuberculosis: a report of 19 cases. ( 19647463 )
2010
33
The infectiousness of laryngeal tuberculosis: appropriate public health action based on false premises. ( 19105872 )
2009
34
Laryngeal tuberculosis: a diagnosis not to be missed. ( 21686402 )
2009
35
Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature. ( 20062778 )
2009
36
The infectiousness of laryngeal tuberculosis. ( 19383206 )
2009
37
Effects of antituberculosis treatment on self assessment, perceptual analysis and acoustic analysis of voice quality in laryngeal tuberculosis patients. ( 17592656 )
2008
38
Laryngeal tuberculosis: a review of 26 cases. ( 17903574 )
2007
39
Laryngeal tuberculosis following laryngeal carcinoma. ( 16359157 )
2006
40
Laryngeal tuberculosis: an important issue. ( 16479029 )
2006
41
Laryngeal tuberculosis: not the usual suspect. ( 16681322 )
2006
42
Current clinical propensity of laryngeal tuberculosis: review of 60 cases. ( 16835742 )
2006
43
Laryngeal tuberculosis presenting as supraglottic carcinoma: case report and literature review. ( 16910293 )
2006
44
Radiology quiz case 3: laryngeal tuberculosis. ( 16103315 )
2005
45
Effects of laryngeal tuberculosis on vocal fold functions: case report. ( 16749607 )
2005
46
Laryngeal tuberculosis. ( 14720571 )
2004
47
Laryngeal tuberculosis: an often forgotten diagnosis. ( 12839714 )
2003
48
Pseudo tumoral laryngeal tuberculosis. ( 12554919 )
2003
49
Contact investigation of a case of pulmonary and laryngeal tuberculosis. ( 12762133 )
2003
50
A case report of difficult diagnosis in the patient with advanced laryngeal tuberculosis. ( 12543178 )
2003

Variations for Laryngeal Tuberculosis

Expression for Laryngeal Tuberculosis

Search GEO for disease gene expression data for Laryngeal Tuberculosis.

Pathways for Laryngeal Tuberculosis

GO Terms for Laryngeal Tuberculosis

Biological processes related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.37 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Laryngeal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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