MCID: LRY007
MIFTS: 34

Laryngeal Tuberculosis

Categories: Respiratory diseases

Aliases & Classifications for Laryngeal Tuberculosis

MalaCards integrated aliases for Laryngeal Tuberculosis:

Name: Laryngeal Tuberculosis 12 15 17
Tuberculosis, Laryngeal 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1583
ICD9CM 36 012.3
MeSH 45 D014387
NCIt 51 C26895
SNOMED-CT 69 70341005
ICD10 34 A15.5
UMLS 74 C0041315

Summaries for Laryngeal Tuberculosis

Disease Ontology : 12 A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

MalaCards based summary : Laryngeal Tuberculosis, also known as tuberculosis, laryngeal, is related to fungal esophagitis and diclofenac allergy. An important gene associated with Laryngeal Tuberculosis is GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase). The drugs Isoniazid and Interferon-gamma have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and trachea, and related phenotypes are Reduced mammosphere formation and renal/urinary system

Related Diseases for Laryngeal Tuberculosis

Diseases related to Laryngeal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.2 ATP12A ATP4A
2 diclofenac allergy 10.2 ATP12A ATP4A
3 gastroduodenal crohn's disease 10.2 ATP12A ATP4A
4 neonatal candidiasis 10.2 ATP12A ATP4A
5 photoallergic dermatitis 10.2 ATP12A ATP4A
6 squamous papillomatosis 10.2 ATP12A ATP4A
7 toxic megacolon 10.2 ATP12A ATP4A
8 aspiration pneumonitis 10.2 ATP12A ATP4A
9 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
10 gastric antral vascular ectasia 10.2 ATP12A ATP4A
11 granulomatous gastritis 10.2 ATP12A ATP4A
12 esophageal candidiasis 10.2 ATP12A ATP4A
13 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
14 larynx cancer 10.2
15 acute laryngitis 10.2 ATP12A ATP4A
16 laryngitis 10.1 ATP12A ATP4A
17 duodenitis 10.1 ATP12A ATP4A
18 rumination disorder 10.1 ATP12A ATP4A
19 active peptic ulcer disease 10.1 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
21 bladder calculus 10.1 ATP12A ATP4A
22 ischemic neuropathy 10.1 ATP12A ATP4A
23 bile reflux 10.1 ATP12A ATP4A
24 capillary disease 10.1 ATP12A ATP4A
25 peptic esophagitis 10.1 ATP12A ATP4A
26 dyskinesia of esophagus 10.1 ATP12A ATP4A
27 hernia, hiatus 10.1 ATP12A ATP4A
28 postsurgical hypothyroidism 10.1 ATP12A ATP4A
29 lymphocytic colitis 10.1 ATP12A ATP4A
30 esophageal atresia/tracheoesophageal fistula 10.1 ATP12A ATP4A
31 clostridium difficile colitis 10.1 ATP12A ATP4A
32 diarrhea 1, secretory chloride, congenital 10.1 ATP12A ATP4A
33 esophagitis, eosinophilic, 1 10.1 ATP12A ATP4A
34 microscopic colitis 10.1 ATP12A ATP4A
35 chronic laryngitis 10.1 ATP12A ATP4A
36 eosinophilic gastritis 10.1 ATP12A ATP4A
37 functional colonic disease 10.1 CD59 KANTR
38 esophagus adenocarcinoma 10.1 ATP12A ATP4A
39 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ATP12A ATP4A
40 jejunoileitis 10.1 ATP12A ATP4A
41 pancreatic steatorrhea 10.1 ATP12A ATP4A
42 esophageal varix 10.1 ATP12A ATP4A
43 superior mesenteric artery syndrome 10.1 ATP12A ATP4A
44 gastric lymphoma 10.1 ATP12A ATP4A
45 lower urinary tract calculus 10.1 ATP12A ATP4A
46 aspiration pneumonia 10.1 ATP12A ATP4A
47 blind loop syndrome 10.1 ATP12A ATP4A
48 functional gastric disease 10.1 ATP12A ATP4A
49 pneumatosis cystoides intestinalis 10.1 ATP12A ATP4A
50 microinvasive gastric cancer 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Laryngeal Tuberculosis:



Diseases related to Laryngeal Tuberculosis

Symptoms & Phenotypes for Laryngeal Tuberculosis

GenomeRNAi Phenotypes related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 ATP4A CD59 GNE POMC

MGI Mouse Phenotypes related to Laryngeal Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 ATP12A CD59 GNE POMC

Drugs & Therapeutics for Laryngeal Tuberculosis

Drugs for Laryngeal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
2 Interferon-gamma Phase 4
3 interferons Phase 4
4 Anti-Bacterial Agents Phase 4
5 Antimetabolites Phase 4
6 Anti-Infective Agents Phase 4
7 Hypolipidemic Agents Phase 4
8 Antitubercular Agents Phase 4
9 Lipid Regulating Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 QuantiFERON®-TB Gold In-Tube for the Diagnosis of Tuberculosis Infection in Contact Tracing Study. Completed NCT01223534 Phase 4 Preventive treatment with Isoniazid.;Preventive treatment with Isoniazid

Search NIH Clinical Center for Laryngeal Tuberculosis

Cochrane evidence based reviews: tuberculosis, laryngeal

Genetic Tests for Laryngeal Tuberculosis

Anatomical Context for Laryngeal Tuberculosis

MalaCards organs/tissues related to Laryngeal Tuberculosis:

42
Lung, Colon, Trachea, Tongue, Skin, Pituitary, Thyroid

Publications for Laryngeal Tuberculosis

Articles related to Laryngeal Tuberculosis:

(show top 50) (show all 162)
# Title Authors Year
1
Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. ( 29017739 )
2018
2
Laryngeal tuberculosis: a rare cause of critical airway obstruction. ( 29348284 )
2018
3
Primary Laryngeal Tuberculosis: Our Experiences at a Tertiary Care Teaching Hospital in Eastern India. ( 29773323 )
2018
4
Laryngeal Tuberculosis Mimicking Laryngeal Carcinoma on 18F-FDG PET/CT Imaging. ( 29889030 )
2018
5
Primary Laryngeal Tuberculosis: A Series of 15 Cases. ( 30251032 )
2018
6
Laryngeal Tuberculosis in Pregnant Women: A Case Report and Review of the Literature. ( 30648077 )
2018
7
Laryngeal tuberculosis: a forgotten disease. ( 28383648 )
2017
8
Tracheobronchopathia osteochondroplastica following laryngeal tuberculosis. ( 28869241 )
2017
9
'A most malignant malady': a rare case of laryngeal tuberculosis in epidermal growth factor receptor mutant lung adenocarcinoma. ( 28994257 )
2017
10
Rigid laryngoscope manifestations of 61 cases of modern laryngeal tuberculosis. ( 29201220 )
2017
11
Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis. ( 27077734 )
2016
12
Palatopharyngoplasty for treatment of nasopharyngeal stenosis secondary to extra-laryngeal tuberculosis. ( 27448412 )
2016
13
Dysphonia - the single symptom of rifampicin resistant laryngeal tuberculosis. ( 28352769 )
2016
14
Laryngeal tuberculosis: A report of 17 cases. ( 25748515 )
2015
15
Laryngeal tuberculosis diagnosed by stool sample cultures: a case report. ( 25886183 )
2015
16
Evaluation of voice disorders in patients with active laryngeal tuberculosis. ( 26009888 )
2015
17
Laryngeal tuberculosis: A public health concern. ( 26535835 )
2015
18
Secondary laryngeal tuberculosis revisited. ( 26628760 )
2015
19
Interferon-γ release assay in the diagnosis of laryngeal tuberculosis. ( 24256035 )
2014
20
Laryngeal tuberculosis: use of videostroboscopy in diagnosis. ( 24526475 )
2014
21
Laryngeal tuberculosis in the United States of America: a forgotten disease. ( 24628484 )
2014
22
Laryngeal tuberculosis: a diagnosis not to be overlooked. ( 25284447 )
2014
23
Primary laryngeal tuberculosis: An unusual cause of hoarseness. ( 25397382 )
2014
24
Clinical features of laryngeal tuberculosis in Iran. ( 24338196 )
2013
25
Atypical presentation of laryngeal tuberculosis in a pediatric patient. ( 22398120 )
2012
26
Laryngeal tuberculosis presenting as laryngeal carcinoma. ( 22755382 )
2012
27
Laryngeal tuberculosis: A case of a non-healing laryngeal lesion. ( 22952563 )
2012
28
Laryngeal tuberculosis: a diagnosis that should be remembered. ( 23037489 )
2012
29
Laryngeal tuberculosis without pulmonary involvement. ( 26557293 )
2012
30
Primary laryngeal tuberculosis. ( 22248835 )
2011
31
Changing trends in the clinical features of laryngeal tuberculosis: a report of 19 cases. ( 19647463 )
2010
32
Primary laryngeal tuberculosis mimicking laryngeal carcinoma: CT scan features. ( 20351985 )
2010
33
Vocal quality of patients treated for laryngeal tuberculosis, before and after speech therapy. ( 20843405 )
2010
34
Primary laryngeal tuberculosis--a rare entity. ( 21043358 )
2010
35
The infectiousness of laryngeal tuberculosis: appropriate public health action based on false premises. ( 19105872 )
2009
36
The infectiousness of laryngeal tuberculosis. ( 19383206 )
2009
37
Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature. ( 20062778 )
2009
38
Laryngeal tuberculosis: a diagnosis not to be missed. ( 21686402 )
2009
39
Effects of antituberculosis treatment on self assessment, perceptual analysis and acoustic analysis of voice quality in laryngeal tuberculosis patients. ( 17592656 )
2008
40
Laryngeal tuberculosis: a review of 26 cases. ( 17903574 )
2007
41
Laryngeal tuberculosis following laryngeal carcinoma. ( 16359157 )
2006
42
Laryngeal tuberculosis: an important issue. ( 16479029 )
2006
43
Laryngeal tuberculosis: not the usual suspect. ( 16681322 )
2006
44
Current clinical propensity of laryngeal tuberculosis: review of 60 cases. ( 16835742 )
2006
45
Laryngeal tuberculosis presenting as supraglottic carcinoma: case report and literature review. ( 16910293 )
2006
46
Radiology quiz case 3: laryngeal tuberculosis. ( 16103315 )
2005
47
Effects of laryngeal tuberculosis on vocal fold functions: case report. ( 16749607 )
2005
48
Laryngeal tuberculosis. ( 14720571 )
2004
49
A case report of difficult diagnosis in the patient with advanced laryngeal tuberculosis. ( 12543178 )
2003
50
Pseudo tumoral laryngeal tuberculosis. ( 12554919 )
2003

Variations for Laryngeal Tuberculosis

Expression for Laryngeal Tuberculosis

Search GEO for disease gene expression data for Laryngeal Tuberculosis.

Pathways for Laryngeal Tuberculosis

GO Terms for Laryngeal Tuberculosis

Biological processes related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.37 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Laryngeal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Laryngeal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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