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MCID: LRY019
MIFTS: 52

Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases
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Aliases & Classifications for Laryngitis

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MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 11 43 14 71 75
Acute Laryngitis 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:3437
MeSH 43 D007827
NCIt 49 C26811
SNOMED-CT 68 45913009
UMLS 71 C0001327 C0023067
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Summaries for Laryngitis

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Disease Ontology: 11 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary: Laryngitis, also known as acute laryngitis, is related to acute laryngitis and chronic laryngitis, and has symptoms including throat irritation An important gene associated with Laryngitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Racepinephrine and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone marrow and salivary gland, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia: 75 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...
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Related Diseases for Laryngitis

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Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1000)
# Related Disease Score Top Affiliating Genes
1 acute laryngitis 32.6 CRP ATP4A ATP12A
2 chronic laryngitis 32.6 HRH2 ATP4A ATP12A
3 viral laryngitis 32.0 CRP ACE2
4 croup 31.2 IL6 CXCL8 CRP CD4 ACE2
5 peptic esophagitis 31.0 TNF IL6 IL1B HRH2 CXCL8 ATP4A
6 gastroesophageal reflux 30.5 TNF TGFB1 IL6 IL4 IL1B HRH2
7 laryngeal tuberculosis 30.5 ATP4A ATP12A
8 haemophilus influenzae 30.1 TNF IL1B CXCL8
9 angina pectoris 30.1 TNF IL6 CRP
10 diphtheria 30.1 TNF IL4 IL1B
11 hernia, hiatus 30.1 HRH2 CRP ATP4A ATP12A
12 syphilis 30.0 TNF CRP CD4
13 pharyngitis 30.0 TNF IL6 IL1B CXCL8 CRP CD4
14 nutritional deficiency disease 30.0 IL6 CRP ATP4A ATP12A
15 esophageal candidiasis 29.9 CD4 ATP4A ATP12A
16 nasopharyngitis 29.9 TNF IL6 CRP
17 pulmonary tuberculosis 29.9 TNF IL6 IL4 IL1B IL10 CRP
18 cyclic neutropenia 29.9 TNF IL1B CXCL8
19 rhinitis 29.9 TNF IL6 IL4 IL1B IL10 CXCL8
20 zollinger-ellison syndrome 29.8 HRH2 ATP4A ATP12A
21 keratoconjunctivitis 29.8 TNF IL4 IL1A
22 myositis 29.8 TNF IL6 IL1B IL1A
23 erysipelas 29.8 TNF IL6 IL1B CRP
24 amyloidosis 29.7 TNF IL6 IL1B CRP
25 mucositis 29.7 TGFB1 IL1B IL10
26 scarlet fever 29.7 TNF IL6 IL1B CRP CD4
27 eosinophilic gastroenteritis 29.6 IL4 ATP4A ATP12A
28 esophagitis 29.6 TNF TGFB1 IL6 IL4 IL1B IL10
29 otitis externa 29.6 IL6 CRP CD4
30 neutrophilic dermatosis, acute febrile 29.6 TNF IL1B CXCL8 CRP
31 mediastinitis 29.6 IL6 CRP CD4 ATP4A ATP12A
32 esophagitis, eosinophilic, 1 29.6 IL4 ATP4A ATP12A
33 bronchitis 29.6 TNF IL6 IL4 IL1B IL10 CXCL8
34 aortitis 29.5 TNF IL6 IL1B CRP CD4
35 candidiasis 29.5 TNF IL6 IL4 IL1B IL1A IL10
36 chronic kidney disease 29.5 TNF TGFB1 IL6 IL1B CRP
37 blastomycosis 29.5 TNF IL6 CRP CD4
38 cervical adenitis 29.5 TNF IL1B CRP CD4
39 cryptococcosis 29.4 TNF IL4 IL10 CD4
40 occupational asthma 29.4 IL4 CXCL8 CD4
41 lymphadenitis 29.4 TNF IL6 IL1B IL10 CXCL8 CRP
42 endocarditis 29.3 TNF IL6 IL1A IL10 CXCL8 CRP
43 keratoconjunctivitis sicca 29.3 TNF IL4 IL1A CD4
44 acquired immunodeficiency syndrome 29.3 TNF IL6 IL1B IL10 CRP CD4
45 pfeiffer syndrome 29.3 TNF IL10 FGF2 CRP CD4
46 miliary tuberculosis 29.3 TNF IL4 IL10 CRP CD4
47 chronic mucocutaneous candidiasis 29.2 IL6 IL4 IL1B IL10 CD4
48 cellulitis 29.2 TNF IL6 IL1B CXCL8 CRP CD4
49 bell's palsy 29.2 TNF IL6 CRP CD4 ACE2
50 otitis media 29.2 TNF IL6 IL4 IL1B IL1A IL10

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis
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Symptoms & Phenotypes for Laryngitis

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UMLS symptoms related to Laryngitis:


throat irritation

GenomeRNAi Phenotypes related to Laryngitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 CXCL8 IL10 IL1A IL1B TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 CXCL8 IL10 IL1B TGFB1 TNF

MGI Mouse Phenotypes related to Laryngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 ACE2 ATP12A ATP4A CD4 CRP FGF2
2 neoplasm MP:0002006 9.97 ATP4A FGF2 IL10 IL1A IL1B IL6
3 digestive/alimentary MP:0005381 9.96 ACE2 ATP12A ATP4A CD4 HRH2 IL10
4 immune system MP:0005387 9.9 ACE2 ATP4A CD4 CRP IL10 IL1A
5 hematopoietic system MP:0005397 9.7 ACE2 ATP4A CD4 FGF2 IL10 IL1A
6 integument MP:0010771 9.28 ACE2 CD4 IL10 IL1A IL1B IL4
Sources

Drugs & Therapeutics for Laryngitis

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Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
2
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
3
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
4
Nimesulide Approved, Investigational, Withdrawn Phase 4 51803-78-2 4495
5
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6 9578005
10
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
11 Neurotransmitter Agents Phase 4
12 Adrenergic Agents Phase 4
13 Fluticasone-Salmeterol Drug Combination Phase 4
14 Adrenergic beta-Agonists Phase 4
15 Adrenergic Agonists Phase 4
16 Sympathomimetics Phase 4
17
Salmeterol Xinafoate Phase 4 94749-08-3
18 Epinephryl borate Phase 4
19 Adrenergic alpha-Agonists Phase 4
20 Vasoconstrictor Agents Phase 4
21 Mydriatics Phase 4
22 Cyclooxygenase 2 Inhibitors Phase 4
23 Antiemetics Phase 4
24 Proton Pump Inhibitors Phase 4
25 Anti-Ulcer Agents Phase 4
26 Antacids Phase 4
27 Gastrointestinal Agents Phase 4
28
Rabeprazole Approved, Investigational Phase 2, Phase 3 117976-89-3, 117976-90-6 5029
29
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
30
Fluticasone Approved, Experimental Phase 3 90566-53-3 4659387 5311101
31
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
32
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
33
Prednisolone Approved, Vet_approved Phase 3 50-24-8 4894 5755
34
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5 1875
35
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 4159 6741
36
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7 4897
37 Psychotropic Drugs Phase 2, Phase 3
38 Antidepressive Agents, Tricyclic Phase 2, Phase 3
39 Antidepressive Agents Phase 2, Phase 3
40 Bronchodilator Agents Phase 3
41 Anti-Asthmatic Agents Phase 3
42 Hormones Phase 3
43 Anti-Allergic Agents Phase 3
44 Xhance Phase 3
45 Hormone Antagonists Phase 3
46 glucocorticoids Phase 3
47 Respiratory System Agents Phase 3
48 Anti-Inflammatory Agents Phase 3
49 Dermatologic Agents Phase 3
50 Pharmaceutical Solutions Phase 3

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 A Pilot Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID as Assessed by the Development of Laryngitis and Oropharyngeal Candidiasis in Adults With Mild Persistent Asthma Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup Unknown status NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
3 A Multicenter, Double -Blind, Placebo-controlled Study to Evaluate the Effects of Esomeprazole 40mg Bid on the Signs and Symptoms of Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
4 Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
5 Laryngopharyngeal Reflux Health Related Quality of Life (LPR-HRQL) Questionnaire Development and Psychometric Testing in Patients Receiving Omeprazole 20 mg Bid as Treatment for Laryngopharyngeal Reflux. Completed NCT00641264 Phase 4 Omeprazole
6 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
7 A Randomized, Placebo-Controlled Assessment of Lansoprazole 30 mg Bid in the Treatment of Gastroesophageal Reflux Associated With Laryngitis Terminated NCT00369265 Phase 4 Lansoprazole
8 Identification of Molecular Markers of Inflammatory Mediators in Posterior Laryngitis Due to Laryngopharyngeal Reflux and Evolution With PPI Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
9 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline Terminated NCT02552225 Phase 2, Phase 3 Amitriptyline
10 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
11 Multicentre, Randomized, Double-blind, Placebo-controlled, Two-arm Parallel Groups Study Design to Demonstrate the Efficacy and Tolerability of a Single Dose of BDP Suspension for Nebulisation 1600 µg vs Placebo in the Treatment of Children Aged 6 Months to 3 Years With a Clinical Diagnosis of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
12 Management of Recurrent Croup: Comparison Between Inhaled Fluticasone and Oral Prednisolone Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
13 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Some Aromatic Medical Plants. Completed NCT00611390 Phase 1, Phase 2
14 Efficacy of Optimal Versus 'Traditional' Delivery of Humidity in Children With Croup Completed NCT00230841 Phase 2
15 Subglottic Instillation of Flurbiprofen to Prevent Laryngeal Inflammation Resulting From Endotracheal Intubation: Prospective Pilot Study, Randomized, Double Blind, Placebo Controlled. Not yet recruiting NCT04708964 Phase 2 Flurbiprofen;saline solution
16 A Prospective Evaluation of the Utility, Optimal Cutoff and Positive Predictive Value of a Pharyngeal pH Probe for Predicting Proton Pump Inhibitor Response in Treatment Naive Laryngopharyngeal Reflux Unknown status NCT01755221
17 Pilotonderzoek Naar Het Gebruik Van Telemedicine Bij Het Beoordelen Van Het Benauwde Kind in de Huisartsenpraktijk English: The Use of Telemedicine in the General Practitioners Office for a Child With Respiratory Symptoms: a Pilot Study Unknown status NCT04168554
18 Method of Early Diagnosis of Laryngopharyngeal Reflux in an Outpatient Appointment of an Otorhinolaryngologist Completed NCT04771221
19 Inter-rater Reliability of the Reflux Finding Score Based on Endoscopic Laryngeal Findings in the Diagnosis of Laryngopharyngeal Reflux Disease Completed NCT02048449
20 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Rabeprazole 20mg twice daily
21 Non Interventional Study Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
22 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
23 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis: Final Results Completed NCT01389401 omeprazole

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Guaifenesin

Cochrane evidence based reviews: laryngitis

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Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

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Organs/tissues related to Laryngitis:

MalaCards : Trachea, Bone Marrow, Salivary Gland, Lung, Skeletal Muscle, Tonsil, Breast
Sources

Publications for Laryngitis

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Articles related to Laryngitis:

(show top 50) (show all 1867)
# Title Authors PMID Year
1
Iron Pill-Induced Chemical Laryngitis. 62
35100816 2023
2
Safety of office-based flexible endoscopic procedures of the pharynx and larynx under topical anesthesia. 62
35916924 2022
3
Gastroesophageal reflux disease and oral health: A narrative review. 62
35605234 2022
4
Isolated Aspergillus Laryngitis: Spectrum, Management, and Review of Literature. 62
33004228 2022
5
Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-κB to alleviate LPS-induced ALI. 62
36002086 2022
6
Evolution of throat symptoms during the COVID-19 pandemic in the US. 62
35976290 2022
7
Developing an Artificial Intelligence Tool to Predict Vocal Cord Pathology in Primary Care Settings. 62
36226791 2022
8
Changes in Otorhinolaryngologic Disease Incidences before and during the COVID-19 Pandemic in Korea. 62
36293687 2022
9
Collaboration between generalist and ENT physicians in COVID-19 Omicron variant-induced laryngitis. 62
36319505 2022
10
Comparing the efficacy and safety of atomization of traditional Chinese medicine Kai Hou Jian and budesonide suspension in adult acute laryngitis: a randomized control trial. 62
36267766 2022
11
Endoscopic aspects and associated factors in paradoxical vocal fold movement. 62
36113920 2022
12
Social Media Data for Omicron Detection from Unscripted Voice Samples. 62
36172131 2022
13
Hoarseness Among Young Children in Day-Care Centers. 62
36180276 2022
14
COVID-19 Omicron variant-induced laryngitis. 62
36114072 2022
15
Reinke's edema management and voice outcomes. 62
36000026 2022
16
Disseminated Talaromyces marneffei infection mimicking laryngitis tuberculosis. 62
35477051 2022
17
Clinical features and influencing factors of curative effect in children with acute laryngitis and laryngeal obstruction. 62
35792017 2022
18
Congenital laryngeal webs: from diagnosis to surgical outcomes. 62
32855093 2022
19
Laryngeal histoplasmosis: masquerading malignancy. 62
35817484 2022
20
Severe spontaneous pneumomediastinum, pneumothorax and subcutaneous emphysema precipitated by pepper spray-induced acute laryngitis: a case report. 62
35356983 2022
21
Acute odynophagia: A new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden. 62
35170099 2022
22
Probiotics as a biotherapeutics for the management and prevention of respiratory tract diseases. 62
35462444 2022
23
Herpes zoster laryngitis. 62
35482516 2022
24
A comparative and correlational study of the Vocal Fatigue Index (VFI) and the Voice Fatigue Handicap Questionnaire (VFHQ) in individuals with and without voice disorders. 62
35610152 2022
25
[Association of temperament type and mother's emotional state with acute respiratory infection in children]. 62
35673920 2022
26
Fibreoptic Laryngoscopic Assessment of Patients with Hoarseness: A Cross-sectional Analysis. 62
36213796 2022
27
Ethnobotanical and phytochemical aspects of the edible herb Coriandrum sativum L. 62
35279837 2022
28
The healing potential of Draksha-guduchyadi kavala in radiotherapy induced oral mucositis in non-metastatic squamous cell carcinoma of head and neck: A comparative case study. 62
34844841 2022
29
The Effect of the MFCC Frame Length in Automatic Voice Pathology Detection. 62
35490081 2022
30
Fifteen-minute consultation: Guide to paediatric voice disorders. 62
33579744 2022
31
Endoscopic findings of laryngitis caused by SARS-CoV-2/Omicron variant infection. 62
35353332 2022
32
The Effect of Upper Airway Ailments on Teachers' Experience of Vocal Fatigue. 62
32624369 2022
33
Systemic Steroids for Otolaryngology-Head and Neck Surgery Disorders: An Evidence-Based Primer for Clinicians. 62
35349383 2022
34
A review on garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities, and toxicology. 62
34904497 2022
35
Primary fungal laryngitis mimicking recurrent laryngeal carcinoma. 62
35140081 2022
36
Laryngitis after inhalation of liposomal amikacin. 62
35369384 2022
37
Glottic Staphylococcus aureus in a patient with systemic lupus erythematosus: videolaryngostroboscopic characteristics. 62
35228218 2022
38
Inhalative Treatment of Laryngitis Sicca in Patients with Sjögren's Syndrome-A Pilot Study. 62
35207348 2022
39
Chronic Bacterial Laryngitis: A Diagnostic Pitfall for Clinicians. 62
34544943 2022
40
Herpes Zoster of The Larynx: A Narrow Diagnostic and Therapeutic Window. 62
35166603 2022
41
Use of a transnasal flexible laryngoscope tip for laryngeal culturing: A novel in-office technique. 62
35155798 2022
42
Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla. 62
35197772 2022
43
Incidence of Voice Disorders among Private School Teachers in Taiwan: A Nationwide Longitudinal Study. 62
35162161 2022
44
Sensation and Repercussion of the Use of Humid Heat in the Treatment of Dysphonia due to Laryngitis in Singers. 62
35078701 2022
45
[Prolonged ulcerative laryngitis]. 62
34170335 2022
46
Fewer non-COVID-19 respiratory tract infections and gastrointestinal infections during the COVID-19 pandemic. 62
34491581 2022
47
An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection. 62
35818376 2022
48
Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States. 62
35111884 2022
49
Respiratory tract infections and risk factors for infection in a cohort of 330 patients with axial spondyloarthritis or psoriatic arthritis. 62
36389682 2022
50
Seasonal Variations in Public Inquiries into Laryngitis: An Infodemiology Study. 62
32439216 2022
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Variations for Laryngitis

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Expression for Laryngitis

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Search GEO for disease gene expression data for Laryngitis.
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Pathways for Laryngitis

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Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 TNF TGFB1 IL6 IL4 IL1B IL1A
2
ERK Signaling 64
Show member pathways
 13.9 TNF TGFB1 IL6 IL4 IL1B IL1A
3
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.67 CD4 CXCL8 IL10 IL1A IL1B IL4
4
TGF-Beta Pathway 64
Show member pathways
 13.58 TNF TGFB1 IL6 IL4 IL1B IL1A
5
Akt Signaling 64
Show member pathways
 13.45 CD4 CXCL8 FGF2 GNRH2 IL10 IL1A
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.38 CD4 CXCL8 FGF2 IL10 IL1A IL1B
7
PAK Pathway 64
Show member pathways
 13.32 TNF TGFB1 IL6 IL4 IL1B IL1A
8
Toll-like receptor signaling pathway 74
Show member pathways
 12.91 TNF TGFB1 IL6 IL1B IL1A CXCL8
9
NF-KappaB Family Pathway 64
Show member pathways
 12.83 TNF TGFB1 IL6 IL1B IL1A GNRH2
10
Malignant pleural mesothelioma 74
12.73 FGF2 IL10 IL1B IL6 TGFB1
11
Immune response IL-23 signaling pathway 22
Show member pathways
 12.7 TNF IL6 IL1B IL10 FGF2 CD4
12
IL-1 Family Signaling Pathways 65
Show member pathways
 12.67 TNF IL6 IL1B IL1A CXCL8
13
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.64 TNF TGFB1 IL6 IL4 IL1B IL1A
14
NF-kappaB Signaling 3
12.56 TNF IL4 IL1B IL10
15
Bacterial infections in CF airways 22
Show member pathways
 12.56 CXCL8 IL1A IL1B IL4 IL6 TNF
16
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.54 CXCL8 IL1B IL6 TNF
17
MAPK signaling pathway 74
12.49 TNF TGFB1 IL1B IL1A FGF2
18
Toll Comparative Pathway 64
Show member pathways
 12.46 TNF IL6 IL1B IL1A FGF2 CXCL8
19
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.3 CXCL8 IL10 IL1A IL1B IL6 TNF
20
T-cell activation SARS-CoV-2 74
Show member pathways
 12.2 TNF IL4 IL10 CD4
21
Hematopoietic Stem Cells and Lineage-specific Markers 65
12.15 CD4 IL10 IL4 IL6 TNF
22
Senescence and autophagy in cancer 74
12.09 TGFB1 IL6 IL1B IL1A CXCL8
23
Spinal cord injury 74
12.08 CXCL8 IL1A IL1B IL4 IL6 TGFB1
24
CCL18 signaling pathway 74
12.05 TGFB1 IL6 IL10 FGF2 CXCL8
25
IL27-mediated signaling events 61
Show member pathways
 12.05 TNF TGFB1 IL6 IL1B IL10 CD4
26
Th17 Differentiation 65
Show member pathways
 12.02 CD4 IL1B IL4 IL6 TGFB1
27
Neuroinflammation and glutamatergic signaling 74
12 FGF2 IL10 IL1A IL1B IL4 IL6
28
IL12-mediated signaling events 61
Show member pathways
 11.97 IL4 IL1B CD4
29
Innate Lymphoid Cells Differentiation 65
11.96 TNF IL4 IL1B IL10 CD4
30
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.94 IL6 CXCL8 CRP CD4 ACE2
31
Burn wound healing 74
11.92 TNF TGFB1 IL6 IL1B CXCL8
32
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.9 TGFB1 IL6 FGF2
33
Extrafollicular B cell activation by SARS-CoV-2 74
11.9 CRP IL10 IL4 IL6 TNF
34
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.89 TGFB1 IL6 CXCL8
35
Acute viral myocarditis 74
11.88 TGFB1 IL6 IL10 CD4
36
Allograft rejection 74
11.88 TNF TGFB1 IL4 IL1B IL1A IL10
37
Th17 cell differentiation pathway 74
11.87 TGFB1 IL6 IL4 IL1B CD4
38
AP-1 transcription factor network 61
11.87 TGFB1 IL6 IL4 IL10 CXCL8
39
Dendritic Cells Developmental Lineage Pathway 65
11.87 CD4 IL10 IL1B IL6 TGFB1 TNF
40
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.83 TNF IL6 IL1B IL1A CXCL8
41
miRNAs involvement in the immune response in sepsis 74
11.81 TNF IL6 IL1A IL10 CXCL8
42
Glucocorticoid receptor regulatory network 61
11.8 IL6 IL4 CXCL8
43
IL 10 signaling pathway 67
11.8 TNF IL6 IL1B IL1A IL10
44
G-protein signaling_RhoA regulation pathway 22
11.74 TGFB1 IL6 GNRH2 FGF2
45
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.74 TNF IL4 CXCL8
46
Inflammatory bowel disease signaling 74
Show member pathways
 11.74 TNF TGFB1 IL6 IL4 IL1A IL10
47
SARS-CoV-2 innate immunity evasion and cell-specific immune response 74
11.7 TNF TGFB1 IL10 CXCL8 ACE2
48
Hepatitis C and hepatocellular carcinoma 74
11.65 TGFB1 IL6 CXCL8
49
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.65 TNF IL6 IL1B IL1A
50
Netrin-UNC5B signaling pathway 74
11.63 TNF IL1A IL10
Sources

GO Terms for Laryngitis

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Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TNF TGFB1 IL6 IL4 IL1B IL1A
2 extracellular space GO:0005615 9.74 ACE2 ATP4A CRP CXCL8 FGF2 GNRH2

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.59 FGF2 IL10 IL1A IL1B IL4 IL6
2 positive regulation of DNA-templated transcription GO:0045893 10.48 CD4 FGF2 IL10 IL1B IL4 IL6
3 signal transduction GO:0007165 10.39 TNF TGFB1 IL6 IL4 IL1B IL10
4 positive regulation of MAPK cascade GO:0043410 10.32 CD4 FGF2 IL6 TNF
5 inflammatory response GO:0006954 10.32 CRP CXCL8 IL1A IL1B IL6 TGFB1
6 positive regulation of angiogenesis GO:0045766 10.31 CXCL8 FGF2 IL1A IL1B
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.28 TNF TGFB1 IL1A FGF2 CD4
8 positive regulation of protein phosphorylation GO:0001934 10.28 CD4 FGF2 IL1B TGFB1 TNF
9 defense response to Gram-positive bacterium GO:0050830 10.27 TNF IL6 IL1B CRP
10 positive regulation of DNA-binding transcription factor activity GO:0051091 10.26 TNF IL6 IL1B IL10
11 positive regulation of interleukin-6 production GO:0032755 10.24 TNF IL6 IL1B IL1A
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.19 TNF TGFB1 IL6 IL1B
13 positive regulation of epithelial to mesenchymal transition GO:0010718 10.19 TGFB1 IL6 IL1B
14 regulation of insulin secretion GO:0050796 10.18 TNF IL6 IL1B
15 response to activity GO:0014823 10.18 TNF IL6 IL10
16 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.17 TNF IL10 FGF2
17 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.15 IL10 IL6 TNF
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.15 IL1A IL1B TNF
19 positive regulation of MAP kinase activity GO:0043406 10.15 TNF TGFB1 IL1B FGF2
20 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.14 IL4 IL1B IL1A
21 positive regulation of interleukin-2 production GO:0032743 10.14 CD4 IL1A IL1B
22 positive regulation of cytokine production GO:0001819 10.14 TNF IL1B IL1A IL10
23 negative regulation of fat cell differentiation GO:0045599 10.13 TNF TGFB1 IL6
24 T cell activation GO:0042110 10.13 TGFB1 IL4 CD4
25 positive regulation of cell division GO:0051781 10.13 TGFB1 IL1B IL1A FGF2
26 cellular response to organic cyclic compound GO:0071407 10.12 TNF TGFB1 IL1B
27 positive regulation of mitotic nuclear division GO:0045840 10.12 IL1A IL1B TNF
28 negative regulation of neurogenesis GO:0050768 10.11 TNF IL6 IL1B
29 response to lipopolysaccharide GO:0032496 10.1 IL10 IL1A IL1B TNF
30 positive regulation of chemokine production GO:0032722 10.1 TNF IL6 IL1B
31 cellular sodium ion homeostasis GO:0006883 10.09 IL1A ATP4A ATP12A
32 protein kinase B signaling GO:0043491 10.09 TNF TGFB1 IL1B FGF2
33 lipopolysaccharide-mediated signaling pathway GO:0031663 10.08 TNF TGFB1 IL1B
34 positive regulation of glial cell proliferation GO:0060252 10.08 IL1B IL6 TNF
35 positive regulation of miRNA transcription GO:1902895 10.08 FGF2 IL10 TGFB1 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.06 TNF IL1B IL10
37 negative regulation of blood vessel endothelial cell migration GO:0043537 10.04 TNF TGFB1 FGF2
38 positive regulation of smooth muscle cell proliferation GO:0048661 10.04 TNF TGFB1 IL6 FGF2
39 type 2 immune response GO:0042092 10.03 IL4 IL10
40 positive regulation of immature T cell proliferation in thymus GO:0033092 10.01 IL1B IL1A
41 negative regulation of cytokine production involved in immune response GO:0002719 10.01 TNF IL10
42 cellular response to lipopolysaccharide GO:0071222 10 CXCL8 IL10 IL1A IL1B IL6 TNF
43 positive regulation of fever generation GO:0031622 9.99 TNF IL1B
44 positive regulation of neuroinflammatory response GO:0150078 9.99 TNF IL6 IL1B
45 regulation of isotype switching GO:0045191 9.98 IL4 IL10
46 sequestering of triglyceride GO:0030730 9.98 TNF IL1B
47 negative regulation of lipid storage GO:0010888 9.97 TNF IL6 CRP
48 negative regulation of cell population proliferation GO:0008285 9.97 TNF TGFB1 IL6 IL1B IL1A IL10
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.96 TNF IL1B
50 fever generation GO:0001660 9.95 IL1B IL1A

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.65 TGFB1 IL6 IL4 IL10 FGF2
2 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.62 ATP4A ATP12A
3 cytokine activity GO:0005125 9.53 TNF TGFB1 IL6 IL4 IL1B IL1A
4 P-type potassium:proton transporter activity GO:0008900 9.46 ATP4A ATP12A
5 P-type potassium transmembrane transporter activity GO:0008556 9.26 ATP4A ATP12A
Sources

Sources for Laryngitis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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