MCID: LRY019
MIFTS: 51

Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 12 43 15 71
Acute Laryngitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3437
MeSH 43 D007827
NCIt 49 C26811
SNOMED-CT 67 45913009
UMLS 71 C0001327 C0023067

Summaries for Laryngitis

Disease Ontology : 12 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and chronic laryngitis, and has symptoms including throat irritation An important gene associated with Laryngitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Fluticasone and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia : 74 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1654)
# Related Disease Score Top Affiliating Genes
1 acute laryngitis 34.4 ATP4A ATP12A
2 chronic laryngitis 33.9 LVRN HRH2 ATP4A ATP12A
3 gastroesophageal reflux 31.4 TNF TGFB1 IL6 IL1B HRH2 GABBR1
4 pulmonary tuberculosis 31.1 TNF IL6 CRP
5 sudden infant death syndrome 30.8 TNF IL6 IL1B IL1A
6 esophagitis 30.6 TNF TGFB1 IL6 IL1B HRH2
7 amyloidosis 30.5 TNF IL6 CRP CD40LG
8 ankylosis 30.5 TNF TGFB1 CRP
9 neuroma 30.5 TGFB1 IL6 FGF2
10 neuritis 30.5 TNF IL6 IL1B
11 pulmonary edema 30.4 TNF IL1B CRP
12 sleep apnea 30.4 TNF IL6 IL1B CRP
13 candidiasis 30.4 TNF IL6 IL1B CD40LG
14 aspergillosis 30.3 TNF IL6 IL1B
15 respiratory failure 30.3 TNF IL6 IL1B CRP
16 cerebral palsy 30.3 TNF IL6 IL1B
17 spondylitis 30.3 TNF IL6 CRP
18 gout 30.3 TNF IL6 IL1B
19 fibrosarcoma 30.2 TNF TGFB1 IL1A FGF2
20 varicose veins 30.2 TNF IL6 FGF2
21 myositis 30.2 TNF IL6 IL1B IL1A
22 extrapulmonary tuberculosis 30.2 TNF IL1B CRP
23 endocarditis 30.2 TNF IL6 CRP
24 angioedema 30.1 IL6 CRP CD40LG
25 leptin deficiency or dysfunction 30.1 TNF IL6 CRP
26 tonsillitis 30.1 TNF IL6 IL1B IL1A
27 post-transplant lymphoproliferative disease 30.1 TNF IL6 IL1A
28 paracoccidioidomycosis 30.1 TNF IL6 CD40LG
29 herpes zoster 30.1 TNF CRP CD40LG
30 measles 30.1 TNF IL6 IL1B CD40LG
31 cytomegalovirus infection 30.1 TNF IL6 IL1B
32 gastrointestinal ulceration, recurrent, with dysfunctional platelets 30.0 HRH2 FGF2
33 visceral leishmaniasis 30.0 TNF IL1B CRP
34 osteomyelitis 30.0 TNF IL6 IL1B IL1A
35 lymphadenitis 30.0 TNF IL1B CRP
36 aspiration pneumonia 30.0 IL6 CRP CD40LG ATP4A ATP12A
37 sarcoidosis 1 30.0 TNF IL1B IL1A CRP CD40LG
38 chickenpox 30.0 TNF IL6 CRP CD40LG
39 pertussis 30.0 TNF IL6 IL1B IL1A
40 influenza 30.0 TNF IL6 IL1B IL1A
41 mononeuropathy 30.0 TNF CRP CD40LG
42 mediastinitis 30.0 CRP ATP4A ATP12A
43 mumps 30.0 TNF IL6 CD40LG
44 bone disease 29.9 TNF IL6 IL1B IL1A
45 leishmaniasis 29.9 TNF TGFB1 IL6 IL1B IL1A CRP
46 vasculitis 29.9 TNF IL6 CRP CD40LG
47 gingivitis 29.9 TNF IL6 IL1B IL1A
48 peptic esophagitis 29.9 IL6 IL1B HRH2 ATP4A ATP12A
49 esophageal cancer 29.9 TNF TGFB1 IL6 IL1B FGF2 CRP
50 miliary tuberculosis 29.9 TNF CRP CD40LG

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:


throat irritation

MGI Mouse Phenotypes related to Laryngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ATP12A ATP4A CD40LG CRP FGF2 GABBR1
2 neoplasm MP:0002006 9.17 ATP4A FGF2 IL1A IL1B IL6 TGFB1

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
4
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
5
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
6
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
7 Neurotransmitter Agents Phase 4
8 Adrenergic Agents Phase 4
9 Sympathomimetics Phase 4
10 Adrenergic beta-Agonists Phase 4
11
Salmeterol xinafoate Phase 4 94749-08-3 56801
12 Anti-Asthmatic Agents Phase 4
13 Hormone Antagonists Phase 4
14 Fluticasone-Salmeterol Drug Combination Phase 4
15 Respiratory System Agents Phase 4
16 Autonomic Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Bronchodilator Agents Phase 4
19 Anti-Allergic Agents Phase 4
20 glucocorticoids Phase 4
21 Hormones Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Anti-Inflammatory Agents, Non-Steroidal Phase 4
24 Cyclooxygenase Inhibitors Phase 4
25 Cyclooxygenase 2 Inhibitors Phase 4
26 Antirheumatic Agents Phase 4
27
Rabeprazole Approved, Investigational Phase 2, Phase 3 117976-89-3 5029
28
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
29
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
30 Tranquilizing Agents Phase 2, Phase 3
31 Antipsychotic Agents Phase 2, Phase 3
32 Analgesics, Non-Narcotic Phase 2, Phase 3
33 Psychotropic Drugs Phase 2, Phase 3
34 Amitriptyline, perphenazine drug combination Phase 2, Phase 3
35 Antidepressive Agents Phase 2, Phase 3
36 Central Nervous System Depressants Phase 2, Phase 3
37 Analgesics Phase 2, Phase 3
38 Antidepressive Agents, Tricyclic Phase 2, Phase 3
39
Peppermint Approved Phase 1, Phase 2
40 Oregano Approved Phase 1, Phase 2
41
Rosemary Experimental Phase 1, Phase 2
42 Eucalyptus Phase 1, Phase 2
43
Nitric Oxide Approved Phase 1 10102-43-9 145068
44 8-epi-prostaglandin F2alpha Phase 1
45 Vasodilator Agents Phase 1
46 Free Radical Scavengers Phase 1
47 Antioxidants Phase 1
48 Protective Agents Phase 1
49
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
50
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 A Pilot Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID as Assessed by the Development of Laryngitis and Oropharyngeal Candidiasis in Adults With Mild Persistent Asthma Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 A Multicenter, Double -Blind, Placebo-controlled Study to Evaluate the Effects of Esomeprazole 40mg Bid on the Signs and Symptoms of Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
3 Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
4 Laryngopharyngeal Reflux Health Related Quality of Life (LPR-HRQL) Questionnaire Development and Psychometric Testing in Patients Receiving Omeprazole 20 mg Bid as Treatment for Laryngopharyngeal Reflux. Completed NCT00641264 Phase 4 Omeprazole
5 Do Laryngeal Biopsy Findings Predict Treatment Response in Suspected Laryngopharyngeal Reflux Completed NCT00444145 Phase 4 Prevacid
6 Role of Esophageal and Laryngeal Biopsies in Suspected Laryngopharyngeal Reflux Completed NCT00373997 Phase 4
7 A Randomized, Placebo-Controlled Assessment of Lansoprazole 30 mg Bid in the Treatment of Gastroesophageal Reflux Associated With Laryngitis Terminated NCT00369265 Phase 4 Lansoprazole
8 A New Nasopharyngeal pH Probe for Diagnosis of Laryngopharyngeal Reflux Withdrawn NCT01308502 Phase 4
9 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
10 A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Alginos Oral Suspension (Sodium Alginate 50 mg/ml) for the Treatment of Patients With Laryngopharyngeal Reflux (LPR) Completed NCT01450748 Phase 3 Sodium alginate;Placebo
11 Identification of Molecular Markers of Inflammatory Mediators in Posterior Laryngitis Due to Laryngopharyngeal Reflux and Evolution With PPI Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
12 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline Enrolling by invitation NCT02552225 Phase 2, Phase 3 Amitriptyline
13 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
14 Effect of Aggressive Acid Suppression With Esomeprazole on Vocal Cord Granulomas: Randomized Placebo-Controlled Trial Withdrawn NCT00567658 Phase 3 Esomeprazole
15 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Some Aromatic Medical Plants. Completed NCT00611390 Phase 1, Phase 2
16 Post-nasal Drainage as an Extraesophageal Manifestation of Reflux Completed NCT00199953 Phase 2 Rabeprazole 20 mg twice a day for 90-day period treatment
17 Comparison of GERD and the Effects of Anti-Reflux Therapy on Pulmonary Function Between Able-Bodied and SCI Individuals Unknown status NCT02584751 Phase 1 Omeprazole
18 A Prospective Evaluation of the Utility, Optimal Cutoff and Positive Predictive Value of a Pharyngeal pH Probe for Predicting Proton Pump Inhibitor Response in Treatment Naive Laryngopharyngeal Reflux Unknown status NCT01755221
19 Comparison Between Inhaled Budesonide and Intravenous Dexamethasone Treatments for Postextubation Stridor in Children Unknown status NCT02056379 Budesonide;Dexamethasone
20 Non Interventional Study Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
21 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Rabeprazole 20mg twice daily
22 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis: Final Results Completed NCT01389401 omeprazole
23 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
24 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
25 Inter-rater Reliability of the Reflux Finding Score Based on Endoscopic Laryngeal Findings in the Diagnosis of Laryngopharyngeal Reflux Disease Completed NCT02048449
26 ADHERE Study: Application of Dx-pH Catheter for Extra-esophageal Reflux Evaluation Completed NCT00388453
27 The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold: a Randomized Trial Completed NCT03309995
28 ELVIS (Esophagitis-Laparoscopy Versus Inhibitors of Secretion) A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication (LNF) Versus Omeprazole for Treatment of Patients With Chronic Gastro-Esophageal Reflux Disease (GERD) Completed NCT00182260 Proton Pump Inhibitors
29 DUAL BRAVO PH MONITORING: A Feasibility Trial Completed NCT00378898
30 Polish Mother and Child Cohort Study (REPRO_PL).Follow up of the Children. Completed NCT01861548
31 The Diagnostics of Extraesophageal Reflux With the Restech System in Patients With Chronic Rhinosinusitis Completed NCT01819454
32 Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit Recruiting NCT04165356
33 Impact of Chronic Rhinosinusitis on the Laryngeal Mucosa and Voice Quality in Children Aged From 6- to 18- Years Old Not yet recruiting NCT03696693
34 Role of Ultrasound in Diagnosis of Laryngeal Lesions Not yet recruiting NCT03450694
35 Does Gastric Reflux Induce Sinonasal Symptoms? Not yet recruiting NCT04105894 medical treatment of GERD t

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Guaifenesin

Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

40
Thyroid, Heart, Bone, Lung, Skin, T Cells, Brain

Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 1712)
# Title Authors PMID Year
1
Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. 61
32024037 2020
2
Scrophularia koraiensis Nakai Attenuates Allergic Airway Inflammation via Suppression of NF-κB and Enhancement of Nrf2/HO-1 Signaling. 61
31991647 2020
3
Characteristics and Voice Outcomes of Ulcerative Laryngitis. 61
30170913 2020
4
Effects of Particle Size of Inhaled Corticosteroid on the Voice. 61
31902681 2020
5
Determinants of successful tracheostomy decannulation in children: a multicentric cohort study. 61
31910909 2020
6
Aspects concerning patient adherence to anti-TNFα therapy in psoriasis: A decade of clinical experience. 61
31798720 2019
7
Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study. 61
31567786 2019
8
A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis. 61
31805893 2019
9
Vocal Characteristics of School-Aged Children With and Without Attention Deficit Hyperactivity Disorder. 61
30115579 2019
10
Leukoplakia or LPR: The Misdiagnosis of Laryngeal Tuberculosis. 61
31779475 2019
11
Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis. 61
31120608 2019
12
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. 61
30912581 2019
13
Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom Index. 61
31586513 2019
14
Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review. 61
31670624 2019
15
Herpes Zoster Laryngitis with Disseminated Cutaneous Lesions. 61
31243199 2019
16
Vocal Characteristics of Patients With Morbid Obesity. 61
31648859 2019
17
Isolated Laryngeal Leishmaniasis: A Diagnostic Dilemma. 61
31742085 2019
18
A Comprehensive Analysis of Benign Vocal Fold Lesions Causing Hoarseness of Voice and Our Experience with Cold Knife Endolaryngeal Surgery in a Tertiary Healthcare Centre. 61
31742013 2019
19
The Role of Allergy in Phonation. 61
30145066 2019
20
The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. 61
31533753 2019
21
Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria. 61
31546651 2019
22
Updates in the field of non-esophageal gastroesophageal reflux disorder. 61
31322443 2019
23
Association of voice and mental health diagnoses with differences in voice-related care utilization. 61
31508825 2019
24
Characteristics of swallowing disorders in patients with dysphonia. 61
32022701 2019
25
Reaction to Clindamycin Causing Laryngitis and Esophagitis. 61
31569974 2019
26
A review for the neuroprotective effects of andrographolide in the central nervous system. 61
31181444 2019
27
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology. 61
29884508 2019
28
Acute supraglottic laryngitis complicated by vocal fold immobility: prognosis and management. 61
31214824 2019
29
Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults. 61
31415057 2019
30
Identification and Management of Chronic Laryngitis. 61
31101358 2019
31
Can the Reflux Finding Score and Reflux Symptom Index Be Used to Evaluate the Severity of Esophagitis in Children? 61
31447186 2019
32
A Novel ALK-THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. 61
31368077 2019
33
Characteristics of a Treatment-seeking Population in a Private Practice Community Voice Clinic: An Epidemiologic Study. 61
29310885 2019
34
Allergic laryngitis: chronic laryngitis and allergic sensitization. 61
30898484 2019
35
Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity. 61
30678486 2019
36
Airflow Patterns of Running Speech in Patients With Voice Disorders. 61
30057271 2019
37
A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx. 61
31104410 2019
38
A comparative and correlative study of the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) for voice-related quality of life among teachers with and without voice disorders. 61
30817565 2019
39
[Influence of TNF-α on the immunomodulatory property of laryngeal mucosa mesenchymal stromal cells']. 61
30909341 2019
40
Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan. 61
30928919 2019
41
Intralesional Cidofovir for Treatment of Acyclovir-Resistant Laryngeal Herpes Manifesting as Supraglottic Mass. 61
30556399 2019
42
[Antibiotic Prescribing in Ambulatory Care of Pediatric Patients with Respiratory Infections]. 61
30896390 2019
43
Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population. 61
30281866 2019
44
Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review. 61
31534961 2019
45
Acute subglottic laryngitis. Etiology, epidemiology, pathogenesis and clinical picture. 61
31680234 2019
46
[Acute and chronic laryngitis in the subjects engaged in the voice and speech professions]. 61
30938347 2019
47
Lung function parameters in patients with gastroesophageal reflux without respiratory symptoms: a case-control study. 61
31749916 2019
48
[Features of microsurgery of the vestibular larynx using CO and a diode laser]. 61
31198217 2019
49
Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study. 61
30535974 2019
50
[Upper respiratory tract infections (sinusitis, otitis, laryngitis ect.)]. 61
30671826 2019

Variations for Laryngitis

Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 TNF TGFB1 IL6 IL1B IL1A GNRH2
2
Show member pathways
13.39 TNF TGFB1 IL6 IL1B IL1A GNRH2
3
Show member pathways
13.34 TNF TGFB1 IL6 IL1B IL1A FGF2
4
Show member pathways
13.27 TNF TGFB1 IL6 IL1B IL1A GNRH2
5
Show member pathways
12.84 TNF TGFB1 IL6 IL1B IL1A CD40LG
6 12.76 TNF TGFB1 IL1B IL1A FGF2
7
Show member pathways
12.6 TNF TGFB1 IL6 IL1B IL1A
8
Show member pathways
12.57 TNF TGFB1 IL6 IL1B IL1A CD40LG
9
Show member pathways
12.33 TNF IL6 IL1B CRP
10
Show member pathways
12.31 TNF IL6 IL1B IL1A FGF2
11
Show member pathways
12.24 TNF TGFB1 IL1B IL1A CD40LG
12
Show member pathways
12.23 TNF IL6 IL1B IL1A
13 12.21 TNF TGFB1 IL6 IL1B IL1A
14
Show member pathways
12.19 TNF TGFB1 IL6 IL1B IL1A GNRH2
15 12.18 TNF IL6 IL1B IL1A
16
Show member pathways
12.18 TNF TGFB1 IL6 IL1B IL1A GNRH2
17
Show member pathways
12.07 TNF TGFB1 IL6 IL1B
18 12.06 TNF TGFB1 IL1B IL1A
19 11.99 TNF TGFB1 IL6 IL1B IL1A
20 11.96 TGFB1 IL6 IL1B IL1A
21 11.94 TNF TGFB1 IL6 IL1B
22 11.91 TNF IL6 IL1B IL1A
23 11.89 TNF IL1B CD40LG
24 11.88 TNF TGFB1 IL6 IL1B IL1A
25 11.82 TNF TGFB1 IL6 IL1B IL1A
26 11.78 IL6 IL1B IL1A
27 11.77 TNF IL6 IL1B IL1A
28 11.75 TNF TGFB1 IL6 IL1B
29 11.73 TNF TGFB1 IL6 IL1B
30 11.7 TGFB1 IL6 GNRH2 FGF2
31 11.69 TNF TGFB1 IL6 IL1B IL1A FGF2
32 11.62 TNF IL6 IL1B
33
Show member pathways
11.57 TNF IL6 IL1B IL1A CD40LG
34 11.54 IL6 IL1B IL1A
35 11.53 TGFB1 IL6 FGF2
36 11.53 TNF TGFB1 IL1B
37 11.53 TNF IL6 IL1B IL1A
38 11.52 TNF TGFB1 IL6 IL1B FGF2
39 11.48 TNF IL6 IL1B IL1A
40 11.41 TNF IL6 IL1B
41 11.38 IL6 IL1B IL1A
42 11.35 TNF TGFB1 IL6 IL1B CD40LG
43 11.34 TNF IL6 IL1B IL1A
44 11.33 TNF IL6 IL1B
45 11.31 TNF IL6 IL1B
46 11.06 TNF IL6 CRP
47 10.91 TNF TGFB1 IL6 IL1B IL1A GNRH2
48 10.85 TNF TGFB1
49 10.54 IL1B IL1A
50 10.48 TNF TGFB1 IL6 IL1B IL1A

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TTLL1 TNF TGFB1 IL6 IL1B IL1A
2 extracellular space GO:0005615 9.36 TNF TGFB1 MIR500A IL6 IL1B IL1A

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 TGFB1 IL6 IL1B HRH2 GNRH2 GABBR1
2 positive regulation of transcription, DNA-templated GO:0045893 10.07 TNF TGFB1 IL6 IL1B FGF2
3 immune response GO:0006955 9.97 TNF IL6 IL1B IL1A HRH2 CD40LG
4 MAPK cascade GO:0000165 9.96 TNF TGFB1 IL1B FGF2
5 positive regulation of gene expression GO:0010628 9.95 TNF TGFB1 IL6 IL1B IL1A CRP
6 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B IL1A
7 defense response to Gram-positive bacterium GO:0050830 9.86 TNF IL6 CRP
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 TNF TGFB1 IL6
9 positive regulation of JNK cascade GO:0046330 9.83 TNF IL1B IL1A
10 cellular response to organic cyclic compound GO:0071407 9.82 TNF TGFB1 IL1B
11 positive regulation of MAP kinase activity GO:0043406 9.81 TNF TGFB1 FGF2
12 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL1B CD40LG
13 negative regulation of fat cell differentiation GO:0045599 9.77 TNF TGFB1 IL6
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 TNF TGFB1 IL6 IL1B CD40LG
15 positive regulation of epithelial to mesenchymal transition GO:0010718 9.76 TGFB1 IL6 IL1B
16 protein kinase B signaling GO:0043491 9.74 TNF TGFB1 IL1B
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 TNF IL1B IL1A
18 positive regulation of interleukin-6 production GO:0032755 9.73 TNF IL6 IL1B IL1A
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TNF TGFB1 IL1B
20 negative regulation of neurogenesis GO:0050768 9.69 TNF IL6 IL1B
21 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 IL1B IL1A
22 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.68 ATP4A ATP12A
23 sodium ion export across plasma membrane GO:0036376 9.67 ATP4A ATP12A
24 cellular potassium ion homeostasis GO:0030007 9.67 ATP4A ATP12A
25 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IL1B
26 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
27 ectopic germ cell programmed cell death GO:0035234 9.64 IL1B IL1A
28 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
29 cytokine-mediated signaling pathway GO:0019221 9.63 TNF TGFB1 IL6 IL1B IL1A FGF2
30 positive regulation of mononuclear cell migration GO:0071677 9.62 TNF TGFB1
31 regulation of immunoglobulin secretion GO:0051023 9.62 TNF CD40LG
32 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
33 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.61 TGFB1 IL1A
34 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
36 positive regulation of cell division GO:0051781 9.56 TGFB1 IL1B IL1A FGF2
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 TNF IL1B
38 fever generation GO:0001660 9.54 IL1B IL1A
39 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
40 positive regulation of vascular endothelial growth factor production GO:0010575 9.26 TGFB1 IL6 IL1B IL1A
41 inflammatory response GO:0006954 9.17 TNF TGFB1 IL6 IL1B IL1A CRP

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.32 IL1B IL1A
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
3 cytokine activity GO:0005125 9.17 TNF TGFB1 IL6 IL1B IL1A FGF2
4 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A

Sources for Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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45 MGI
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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