MCID: LRY019
MIFTS: 54

Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 12 45 15 74
Acute Laryngitis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3437
MeSH 45 D007827
NCIt 51 C26811
SNOMED-CT 69 45913009

Summaries for Laryngitis

Disease Ontology : 12 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to laryngeal disease and acute laryngitis, and has symptoms including throat irritation An important gene associated with Laryngitis is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and TGF-Beta Pathway. The drugs Fluticasone and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and tonsil, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 77 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 975)
# Related Disease Score Top Affiliating Genes
1 laryngeal disease 33.6 ATP12A ATP4A
2 acute laryngitis 33.5 ATP12A ATP4A
3 laryngeal tuberculosis 33.4 ATP12A ATP4A
4 chronic laryngitis 33.1 ATP12A ATP4A HRH2
5 lateral medullary syndrome 31.4 ATP12A ATP4A
6 sudden infant death syndrome 30.2 IL1B IL6 TNF
7 apnea, obstructive sleep 30.2 IL6 TNF
8 pneumonia 30.1 IL1B IL6 TNF
9 spinal cord injury 30.0 IL6 TGFB1 TNF
10 burns 30.0 IL1B TNF
11 aspiration pneumonia 30.0 ATP12A ATP4A
12 acquired immunodeficiency syndrome 29.9 IL1B IL6 TNF
13 sleep apnea 29.8 IL1B IL6 TNF
14 hematopoietic stem cell transplantation 29.8 IL6 TNF
15 myeloma, multiple 29.8 FGF2 IL6 TNF
16 arthritis 29.7 IL1B IL6 TGFB1 TNF
17 myelitis 29.7 IL6 TNF
18 cysticercosis 29.7 IL1B IL6
19 pertussis 29.7 IL1B IL6 TNF
20 rheumatoid arthritis 29.6 IL1B IL6 TGFB1 TNF
21 aphthous stomatitis 29.5 IL1B IL6 TNF
22 autoimmune disease 29.5 IL1B IL6 TNF
23 gastroenteritis 29.5 IL1B IL6 TNF
24 chronic mucocutaneous candidiasis 29.5 IL1B IL6 TNF
25 esophagitis 29.5 HRH2 IL1B IL6 TGFB1
26 otitis media 29.5 IL1B IL6 TNF
27 rheumatic heart disease 29.4 IL6 TGFB1 TNF
28 asthma 29.4 HRH2 IL1B IL6 TNF
29 pulmonary disease, chronic obstructive 29.3 IL6 TGFB1 TNF
30 adult-onset still's disease 29.3 IL1B IL6 TNF
31 acute respiratory distress syndrome 29.3 IL1B IL6 TNF
32 pericarditis 29.3 IL1B IL6 TNF
33 esophagitis, eosinophilic, 1 29.3 ATP12A ATP4A
34 typhoid fever 29.3 IL1B IL6 TNF
35 tonsillitis 29.3 IL1B IL6 TNF
36 lyme disease 29.3 IL1B IL6 TNF
37 meningitis 29.3 IL1B IL6 TNF
38 toxic shock syndrome 29.3 IL1B IL6 TNF
39 silicosis 29.2 IL1B TGFB1 TNF
40 graft-versus-host disease 29.2 IL1B IL6 TNF
41 cerebral palsy 29.2 IL1B IL6 TNF
42 trypanosomiasis 29.2 IL1B IL6 TNF
43 haemophilus influenzae 29.2 IL1B TNF
44 lung disease 29.2 IL1B IL6 TGFB1 TNF
45 aspiration pneumonitis 29.1 ATP12A ATP4A HRH2
46 chagas disease 29.0 IL1B IL6 TGFB1 TNF
47 inflammatory bowel disease 29.0 IL1B IL6 TGFB1 TNF
48 hernia, hiatus 28.9 ATP12A ATP4A
49 peptic esophagitis 28.3 ATP12A ATP4A HRH2 IL1B
50 laryngeal papillomatosis 12.5

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Ischemic Heart Disease Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:


throat irritation

MGI Mouse Phenotypes related to Laryngitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 ATP12A ATP4A HRH2 IL6 TGFB1 TNF
2 homeostasis/metabolism MP:0005376 9.56 ATP12A ATP4A FGF2 HRH2 IL1B IL6
3 neoplasm MP:0002006 9.1 ATP4A FGF2 IL1B IL6 TGFB1 TNF

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4,Phase 3 90566-53-3 62924
2
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
5
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
7
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
8
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
9
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
12
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
13 Fluticasone-Salmeterol Drug Combination Phase 4
14 Adrenergic beta-Agonists Phase 4
15 Anti-Allergic Agents Phase 4,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
17 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
18 Adrenergic Agonists Phase 4
19 Adrenergic beta-2 Receptor Agonists Phase 4
20 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
21 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
22 Autonomic Agents Phase 4,Phase 3,Not Applicable
23 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
24 Sympathomimetics Phase 4
25 Hormone Antagonists Phase 4,Phase 3,Not Applicable
26 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
27 Adrenergic Agents Phase 4,Phase 2,Phase 3
28 Respiratory System Agents Phase 4,Phase 3,Not Applicable
29 Dermatologic Agents Phase 4,Phase 3
30
Salmeterol xinafoate Phase 4 94749-08-3 56801
31 glucocorticoids Phase 4,Phase 3,Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
33 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
34 Proton Pump Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
35 BB 1101 Phase 4,Not Applicable
36
protease inhibitors Phase 4,Not Applicable
37 HIV Protease Inhibitors Phase 4,Not Applicable
38 Antiemetics Phase 4,Phase 3,Not Applicable
39 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
40 Epinephryl borate Phase 4,Not Applicable
41 Antacids Phase 4,Phase 2,Phase 3,Not Applicable
42 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Not Applicable
43 Cyclooxygenase Inhibitors Phase 4
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Cyclooxygenase 2 Inhibitors Phase 4
46 Antirheumatic Agents Phase 4
47 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
48 Analgesics Phase 4,Phase 2,Phase 3
49 Adrenergic alpha-Agonists Phase 4
50 Mydriatics Phase 4

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
3 Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
4 Quality of Life Validation in Laryngitis Completed NCT00641264 Phase 4 Omeprazole
5 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
6 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
7 Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Recruiting NCT03705273 Phase 4 Dexamethasone IV for PO;Dexamethasone crushed tablets
8 Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux Terminated NCT00369265 Phase 4 Lansoprazole
9 Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias Unknown status NCT01408108 Phase 3
10 Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh Unknown status NCT01780285 Phase 3
11 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
12 Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
13 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
14 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
15 E. Coli Nissle 1917 - Suspension for Infection Prophylaxis Active, not recruiting NCT02802059 Phase 3 EcN-Suspension;Placebo
16 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
17 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
18 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
19 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
20 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants Completed NCT00611390 Phase 1, Phase 2
21 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
22 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
23 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children Completed NCT00767416 Phase 1, Phase 2
24 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
25 Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR Unknown status NCT01755221 Not Applicable
26 Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children Unknown status NCT02056379 Not Applicable Budesonide;Dexamethasone
27 Intestinal Microbiota Composition After Antibiotic Treatment in Early Life Unknown status NCT02536560
28 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220 Not Applicable
29 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole
30 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Not Applicable Rabeprazole 20mg twice daily
31 Non Interventional Study (NIS) Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
32 Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists Completed NCT02048449
33 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
34 Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments Completed NCT01767064 Not Applicable
35 The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold Completed NCT03309995 Not Applicable
36 A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children Completed NCT00626808 No Intervention
37 Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children. Completed NCT01861548
38 Repeated Versus Varied Simulation Scenarios to Teach Medical Students the Management of a Pediatric Asthma Exacerbation Completed NCT02754310 Not Applicable
39 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849 Not Applicable

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

42
Bone, Testes, Tonsil, Heart, Trachea, Lung, Colon

Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 425)
# Title Authors Year
1
Allergic laryngitis: chronic laryngitis and allergic sensitization. ( 30898484 )
2019
2
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. ( 30912581 )
2019
3
Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study. ( 30535974 )
2019
4
Sweet's syndrome with laryngoparalysis due to laryngitis. ( 29696681 )
2018
5
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
6
Use of a national identification database to determine the lifetime prognosis in cattle with necrotic laryngitis and the predictive value of venous pCO<sub>2</sub>. ( 29968934 )
2018
7
SWALLOWING IN PATIENTS WITH LARYNGITIS. ( 29561977 )
2018
8
Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )
2018
9
Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease? ( 30297197 )
2018
10
Herpes simplex laryngitis presenting as airway obstruction in a stroke patient. ( 30186766 )
2018
11
Characteristics and Voice Outcomes of Ulcerative Laryngitis. ( 30170913 )
2018
12
Acute infectious laryngitis: A case series. ( 30273430 )
2018
13
Factors Associated With Infectious Laryngitis: A Retrospective Review of 15 Cases. ( 28397557 )
2017
14
There is no correlation between signs of reflux laryngitis and reflux oesophagitis in patients with gastro-oesophageal reflux disease symptoms. ( 29165435 )
2017
15
TNF-I+ inhibitor as a cause of refractory suppurative laryngitis and rhinosinusitis. ( 28931201 )
2017
16
<i>Saccharomyces cerevisiae</i> Laryngitis and Oral Lesions in a Patient with Laryngeal Carcinoma. ( 29318065 )
2017
17
MRSA chronic bacterial laryngitis: A growing problem. ( 29086424 )
2017
18
Allergic laryngitis: unraveling the myths. ( 28266945 )
2017
19
Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction: A Case Report and Literature Review. ( 28397560 )
2017
20
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
21
Pulsed dye laser treatment of primary cryptococcal laryngitis: A novel approach to an uncommon disease. ( 27654751 )
2016
22
Herpes zoster laryngitis in a patient treated with fingolimod. ( 27553068 )
2016
23
Laryngitis obscuring an anterior glottic mass. ( 26829678 )
2016
24
Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial. ( 27126336 )
2016
25
What Role Does Allergy Play in Chronic Ear Disease and Laryngitis? ( 27783318 )
2016
26
Subglottic laryngitis--Changes in therapy approach over the past 20 years. ( 25921270 )
2015
27
Viral laryngitis: a mimic and a monster - range, presentation, management. ( 26397458 )
2015
28
Utility of Allergy Testing in Patients with Chronic Laryngopharyngeal Symptoms: Is It Allergic Laryngitis? ( 26428475 )
2015
29
The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )
2015
30
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )
2015
31
Ramsay Hunt syndrome and zoster laryngitis with multiple cranial nerve involvement. ( 26793453 )
2015
32
Idiopathic Ulcerative Laryngitis: An uncommon disease. ( 26748984 )
2015
33
Eosinophilic Laryngitis in Children with Aerodigestive Dysfunction. ( 25820587 )
2015
34
Antibiotics for acute laryngitis in adults. ( 26002823 )
2015
35
1263: A CASE OF LARYNGITIS CAUSED BY AN UNUSUAL SUSPECT. ( 26570924 )
2015
36
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )
2015
37
Proliferative laryngitis with airway obstruction in an adult: Consider herpes. ( 26297873 )
2015
38
Candida laryngitis appearing as carcinoma. ( 26644902 )
2015
39
Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model. ( 26197967 )
2015
40
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )
2015
41
Cryptococcal laryngitis: An uncommon presentation of a common pathogen. ( 26636155 )
2015
42
Finnish guidelines for the treatment of laryngitis, wheezing bronchitis and bronchiolitis in children. ( 26295564 )
2015
43
Reflux Laryngitis: Correlation between the Symptoms Findings and Indirect Laryngoscopy. ( 26157498 )
2015
44
Salivary transforming growth factor alpha in patients with SjAPgren's syndrome and reflux laryngitis. ( 25457064 )
2014
45
Human laryngitis caused by Clinostomum complanatum. ( 25130004 )
2014
46
Severe candida laryngitis in a patient with rheumatoid arthritis treated with adalimumab. ( 27708907 )
2014
47
Fungal laryngitis in immunocompetent patients. ( 24533421 )
2014
48
Current perspectives on reflux laryngitis. ( 25491904 )
2014
49
Laryngitis. ( 25300640 )
2014
50
Effects of reflux laryngitis on non-nutritive swallowing in newborn lambs. ( 24893350 )
2014

Variations for Laryngitis

Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ATP12A ATP4A IL1B IL6 TGFB1 TNF
2
Show member pathways
13.38 FGF2 IL1B IL6 TGFB1 TNF
3
Show member pathways
13.27 FGF2 IL1B IL6 TGFB1 TNF
4
Show member pathways
13.22 FGF2 IL1B IL6 TGFB1 TNF
5
Show member pathways
13.16 FGF2 IL1B IL6 TGFB1 TNF
6
Show member pathways
13.06 IL1B IL6 TGFB1 TNF
7
Show member pathways
12.83 FGF2 IL1B IL6 TGFB1 TNF
8
Show member pathways
12.77 IL1B IL6 TGFB1 TNF
9 12.65 FGF2 IL1B TGFB1 TNF
10
Show member pathways
12.54 FGF2 IL1B IL6 TGFB1 TNF
11
Show member pathways
12.49 IL1B IL6 TGFB1 TNF
12
Show member pathways
12.48 FGF2 IL1B IL6 TNF
13
Show member pathways
12.34 IL1B IL6 TGFB1 TNF
14 12.26 IL6 TGFB1 TNF
15
Show member pathways
12.24 IL1B IL6 TNF
16
Show member pathways
12.24 IL1B IL6 TNF
17
Show member pathways
12.22 FGF2 IL1B IL6 TNF
18 12.21 FGF2 TGFB1 TNF
19
Show member pathways
12.17 IL1B TGFB1 TNF
20
Show member pathways
12.14 IL1B IL6 TNF
21
Show member pathways
12.13 IL1B IL6 TNF
22
Show member pathways
12.13 IL6 TGFB1 TNF
23 12.13 IL1B IL6 TGFB1 TNF
24
Show member pathways
12.1 IL1B IL6 TNF
25 12.1 IL6 TGFB1 TNF
26 12.09 IL1B IL6 TNF
27
Show member pathways
12.08 FGF2 TGFB1 TNF
28
Show member pathways
12.08 FGF2 IL1B IL6 TGFB1 TNF
29 11.99 FGF2 IL6 TGFB1
30 11.98 IL6 TGFB1 TNF
31
Show member pathways
11.97 FGF2 IL1B IL6 TGFB1
32 11.96 IL1B TGFB1 TNF
33
Show member pathways
11.95 IL1B IL6 TNF
34
Show member pathways
11.93 IL1B IL6 TGFB1 TNF
35 11.89 IL1B IL6 TNF
36 11.87 IL1B IL6 TGFB1
37 11.87 IL1B IL6 TGFB1 TNF
38 11.83 IL1B IL6 TNF
39 11.76 IL1B IL6 TGFB1 TNF
40 11.72 IL1B IL6 TGFB1 TNF
41 11.7 IL1B IL6 TNF
42 11.66 IL1B IL6 TGFB1 TNF
43
Show member pathways
11.61 IL1B IL6 TNF
44 11.54 IL1B IL6 TGFB1 TNF
45 11.53 IL1B IL6 TNF
46 11.48 IL1B IL6 TNF
47 11.47 IL1B IL6 TGFB1 TNF
48 11.46 IL1B TGFB1 TNF
49 11.46 FGF2 IL6 TGFB1
50 11.42 IL1B IL6 TNF

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ATP4A FGF2 IL1B IL6 TGFB1 TNF

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 FGF2 IL1B IL6 TGFB1
2 immune response GO:0006955 9.97 HRH2 IL1B IL6 TNF
3 positive regulation of gene expression GO:0010628 9.95 IL1B IL6 TGFB1 TNF
4 inflammatory response GO:0006954 9.93 IL1B IL6 TGFB1 TNF
5 positive regulation of transcription, DNA-templated GO:0045893 9.93 FGF2 IL1B IL6 TGFB1 TNF
6 leukocyte migration GO:0050900 9.88 IL1B TGFB1 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.88 IL1B TGFB1 TNF
8 positive regulation of protein kinase B signaling GO:0051897 9.87 FGF2 TGFB1 TNF
9 cellular response to lipopolysaccharide GO:0071222 9.87 IL1B IL6 TNF
10 activation of MAPK activity GO:0000187 9.83 FGF2 IL1B TNF
11 MAPK cascade GO:0000165 9.83 FGF2 IL1B TGFB1 TNF
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 IL1B IL6 TNF
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 IL6 TGFB1 TNF
14 cellular response to organic cyclic compound GO:0071407 9.78 IL1B TGFB1 TNF
15 regulation of signaling receptor activity GO:0010469 9.77 FGF2 IL1B IL6 TGFB1 TNF
16 positive regulation of MAP kinase activity GO:0043406 9.76 FGF2 TGFB1 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.75 IL1B IL6 TNF
18 negative regulation of blood vessel endothelial cell migration GO:0043537 9.74 FGF2 TGFB1
19 potassium ion import across plasma membrane GO:1990573 9.73 ATP12A ATP4A
20 positive regulation of phagocytosis GO:0050766 9.73 IL1B TNF
21 regulation of angiogenesis GO:0045765 9.73 FGF2 IL6
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 IL1B TNF
23 negative regulation of mitotic cell cycle GO:0045930 9.73 TGFB1 TNF
24 digestive tract development GO:0048565 9.73 HRH2 TGFB1
25 osteoclast differentiation GO:0030316 9.72 TGFB1 TNF
26 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.72 FGF2 TGFB1
27 ATP hydrolysis coupled proton transport GO:0015991 9.72 ATP12A ATP4A
28 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TNF
29 positive regulation of vascular endothelial growth factor production GO:0010575 9.72 IL1B TGFB1
30 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.72 FGF2 TGFB1 TNF
31 negative regulation of myoblast differentiation GO:0045662 9.71 TGFB1 TNF
32 positive regulation of protein complex assembly GO:0031334 9.71 TGFB1 TNF
33 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
34 positive regulation of histone acetylation GO:0035066 9.7 IL1B TGFB1
35 cellular sodium ion homeostasis GO:0006883 9.69 ATP12A ATP4A
36 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
37 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
38 hyaluronan catabolic process GO:0030214 9.68 FGF2 TGFB1
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
40 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.67 ATP12A ATP4A
41 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
42 cellular potassium ion homeostasis GO:0030007 9.66 ATP12A ATP4A
43 sodium ion export across plasma membrane GO:0036376 9.65 ATP12A ATP4A
44 negative regulation of fat cell differentiation GO:0045599 9.65 IL6 TGFB1 TNF
45 negative regulation of lipid storage GO:0010888 9.64 IL6 TNF
46 wound healing GO:0042060 9.63 FGF2 TGFB1
47 positive regulation of cell division GO:0051781 9.63 FGF2 IL1B TGFB1
48 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
49 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
50 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.62 IL1B IL6 TGFB1 TNF

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 FGF2 IL6 TGFB1
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 cytokine activity GO:0005125 9.02 FGF2 IL1B IL6 TGFB1 TNF
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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