Laryngitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRY019 MIFTS: 56	Laryngitis Categories: Respiratory diseases, Infectious diseases
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Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis ¹² ⁴⁴ ¹⁵ ⁷³

Acute Laryngitis ⁷³

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3437

MeSH ⁴⁴ D007827

NCIt ⁵⁰ C26811

SNOMED-CT ⁶⁸ 45913009

UMLS ⁷³ C0023067

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Summaries for Laryngitis

Disease Ontology : ¹² A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and laryngeal disease, and has symptoms including throat irritation An important gene associated with Laryngitis is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and TGF-Beta Pathway. The drugs Omeprazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thyroid and lung, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : ⁷⁶ Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

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Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis	Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 783)

#	Related Disease	Score	Top Affiliating Genes
1	acute laryngitis	33.4	ATP12A ATP4A
2	laryngeal disease	33.0	ATP12A ATP4A
3	laryngeal tuberculosis	33.0	ATP12A ATP4A
4	chronic laryngitis	32.4	ATP12A ATP4A HRH2
5	burns	30.0	IL1B TNF
6	pneumonia	30.0	IL1B IL6 TNF
7	apnea, obstructive sleep	29.9	IL6 TNF
8	esophagitis	29.9	HRH2 IL1B IL6
9	myelitis	29.9	IL6 TNF
10	acquired immunodeficiency syndrome	29.7	IL1B IL6 TNF
11	sudden infant death syndrome	29.7	IL1B IL6 TNF
12	aspiration pneumonia	29.6	ATP12A ATP4A
13	pertussis	29.6	IL1B IL6 TNF
14	arthritis	29.6	IL1B IL6 TNF
15	spinal cord injury	29.5	IL6 TGFB1 TNF
16	paracoccidioidomycosis	29.5	IL6 TNF
17	tonsillitis	29.5	IL1B IL6 TNF
18	gastroenteritis	29.5	IL1B IL6 TNF
19	pulmonary disease, chronic obstructive	29.4	IL6 TGFB1 TNF
20	lung disease	29.3	IL1B TGFB1 TNF
21	duodenitis	29.3	ATP12A ATP4A
22	aphthous stomatitis	29.3	IL1B IL6 TNF
23	pericarditis	29.2	IL1B IL6 TNF
24	gingivitis	29.2	IL1B IL6 TNF
25	peritonitis	29.2	IL1B IL6 TNF
26	graft-versus-host disease	29.2	IL1B IL6 TNF
27	silicosis	29.2	IL1B TGFB1 TNF
28	prostatitis	29.1	IL1B IL6 TGFB1 TNF
29	hernia, hiatus	29.0	ATP12A ATP4A
30	rheumatoid arthritis	29.0	IL1B IL6 TGFB1 TNF
31	esophagitis, eosinophilic, 1	28.8	ATP12A ATP4A
32	aspiration pneumonitis	28.4	ATP12A ATP4A HRH2
33	paine syndrome	28.2	ATP12A ATP4A IL1B
34	asthma	27.7	HRH2 IL1B IL6 TGFB1 TNF
35	laryngeal papillomatosis	12.3
36	laryngeal cleft	12.3
37	laryngeal web, familial	12.2
38	viral laryngitis	12.1
39	congenital laryngeal palsy	12.1
40	larynx cancer	12.1
41	laryngeal cartilage cancer	12.0
42	laryngeal abductor paralysis	12.0
43	laryngeal small cell carcinoma	12.0
44	supraglottic laryngeal cancer	11.9
45	laryngeal adenoid cystic carcinoma	11.9
46	laryngeal mucoepidermoid carcinoma	11.9
47	laryngeal adductor paralysis	11.9
48	congenital laryngeal cyst	11.9
49	laryngeal atresia, encephalocele, and limb deformities	11.9
50	hirschsprung disease with heart defects, laryngeal anomalies, and preaxial polydactyly	11.8

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Bronchitis
Deficiency Anemia	Esophagitis
Heart Disease	Hypertension, Essential
Ischemic Heart Disease	Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:

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Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

throat irritation

MGI Mouse Phenotypes related to Laryngitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.63	ATP12A ATP4A HRH2 IL6 TGFB1 TNF
2	homeostasis/metabolism	MP:0005376	9.56	ATP12A ATP4A FGF2 HRH2 IL1B IL6
3	neoplasm	MP:0002006	9.02	FGF2 IL1B IL6 TGFB1 TNF

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Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

73590-58-6

4594

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

50-02-2

5743

Epinephrine

Approved, Vet_approved

Phase 4,Not Applicable

51-43-4

5816

Fluticasone

Approved, Experimental, Investigational

Phase 4,Phase 3

90566-53-3

62924

Racepinephrine

Approved

Phase 4,Not Applicable

329-65-7

838

Esomeprazole

Approved, Investigational

Phase 4

161796-78-7, 119141-88-7

4594 9579578

Meloxicam

Approved, Vet_approved

Phase 4

71125-38-7

5281106 54677470

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Dexlansoprazole

Approved, Investigational

Phase 4

138530-94-6, 103577-45-3

9578005

Salmeterol xinafoate

Phase 4

94749-08-3

56801

Dexamethasone acetate

Phase 4,Not Applicable

1177-87-3

glucocorticoids

Phase 4,Phase 3,Not Applicable

protease inhibitors

Phase 4,Not Applicable

Respiratory System Agents

Phase 4,Phase 3,Not Applicable

Fluticasone Propionate, Salmeterol Xinafoate Drug Combination

Phase 4

Adrenergic Agents

Phase 4,Phase 2,Phase 3

Adrenergic Agonists

Phase 4

Adrenergic beta-2 Receptor Agonists

Phase 4

Adrenergic beta-Agonists

Phase 4

Gastrointestinal Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3

HIV Protease Inhibitors

Phase 4,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Not Applicable

Dermatologic Agents

Phase 4,Phase 3

Hormones

Phase 4,Phase 2,Phase 3,Not Applicable

Anti-Allergic Agents

Phase 4,Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Epinephryl borate

Phase 4,Not Applicable

Antiemetics

Phase 4,Phase 3,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Not Applicable

Proton Pump Inhibitors

Phase 4,Phase 2,Phase 3,Not Applicable

BB 1101

Phase 4,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Not Applicable

Bronchodilator Agents

Phase 4,Phase 3,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Not Applicable

Analgesics

Phase 4,Phase 2,Phase 3

Cyclooxygenase Inhibitors

Phase 4

Analgesics, Non-Narcotic

Phase 4,Phase 2,Phase 3

Antacids

Phase 4,Phase 2,Phase 3,Not Applicable

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Anti-Ulcer Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Antirheumatic Agents

Phase 4

Adrenergic alpha-Agonists

Phase 4

Mydriatics

Phase 4

Vasoconstrictor Agents

Phase 4

Silicon

Approved, Investigational

Phase 3

7440-21-3

4082203

Interventional clinical trials:

(show all 38)

#	Name	Status	NCT ID	Phase	Drugs
1	Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID	Unknown status	NCT00235053	Phase 4	fluticasone/salmeterol DISKUS 250/50
2	Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux	Completed	NCT00628667	Phase 4	Esomeprazole;Placebo
3	Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis	Completed	NCT02229747	Phase 4	Meloxicam;Diclofenac;Nimesulide
4	Quality of Life Validation in Laryngitis	Completed	NCT00641264	Phase 4	Omeprazole
5	Community Care for Croup (RCT)	Completed	NCT01042145	Phase 4	Prednisone;Dexamethasone
6	The Effect and Safety of Low Dose Nebulized Epinephrine in Croup	Recruiting	NCT01664507	Phase 4	conventional dose epinephrine;low dose epinephrine
7	Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux	Terminated	NCT00369265	Phase 4	Lansoprazole
8	Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias	Unknown status	NCT01408108	Phase 3
9	Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh	Unknown status	NCT01780285	Phase 3
10	Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants	Unknown status	NCT01249911	Phase 3
11	Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment	Completed	NCT00204698	Phase 2, Phase 3	Aciphex
12	CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study	Completed	NCT01948856	Phase 3	J022X ST;Placebo
13	Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial	Completed	NCT01304927	Phase 2, Phase 3	Cholecalciferol and calcium
14	E. Coli Nissle 1917 - Suspension for Infection Prophylaxis	Recruiting	NCT02802059	Phase 3	EcN-Suspension;Placebo
15	Treatment of Chronic Laryngitis With Amitriptyline	Suspended	NCT02552225	Phase 2, Phase 3	Amitriptyline
16	Trial of the Treatment of Chronic Laryngitis With Amitryptiline	Terminated	NCT02434523	Phase 2, Phase 3	Amitriptyline
17	Management of Recurrent Croup	Terminated	NCT01748162	Phase 3	Fluticasone;Prednisolone IF needed
18	Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup	Terminated	NCT00938353	Phase 3	beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
19	Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants	Completed	NCT00611390	Phase 1, Phase 2
20	Comparing Different Ways of Delivering Humidity to Children With Croup	Completed	NCT00230841	Phase 2
21	A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants	Completed	NCT00686075	Phase 1, Phase 2
22	A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children	Completed	NCT00767416	Phase 1, Phase 2
23	Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age	Completed	NCT00493285	Phase 1
24	Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR	Unknown status	NCT01755221	Not Applicable
25	Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children	Unknown status	NCT02056379	Not Applicable	Budesonide;Dexamethasone
26	Intestinal Microbiota Composition After Antibiotic Treatment in Early Life	Unknown status	NCT02536560
27	Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis	Completed	NCT01806220	Not Applicable
28	Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis	Completed	NCT01389401		omeprazole
29	Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients	Completed	NCT00517114	Not Applicable	Rabeprazole 20mg twice daily
30	Non Interventional Study (NIS) Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis	Completed	NCT02160912
31	Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists	Completed	NCT02048449
32	Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)	Completed	NCT01406275		Amoxicillin and clavulanate
33	Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments	Completed	NCT01767064	Not Applicable
34	A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children	Completed	NCT00626808		No Intervention
35	Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children.	Completed	NCT01861548
36	Repeated Versus Varied Simulation Scenarios to Teach Medical Students the Management of a Pediatric Asthma Exacerbation	Completed	NCT02754310	Not Applicable
37	The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold	Enrolling by invitation	NCT03309995	Not Applicable
38	A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup	Terminated	NCT00147849	Not Applicable

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

guaifenesin

Cochrane evidence based reviews: laryngitis

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Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

⁴¹

Lymph Node, Thyroid, Lung, Endothelial, Bone, T Cells, Tongue

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Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 3636)

#	Title	Authors	Year
1	Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. ( 29673563 )	Ueha R....Yamasoba T.	2018
2	Laryngeal Chondrosarcoma: A rare cause of critical upper airway obstruction. ( 29869857 )	Tuite K....Kinsella J.B.	2018
3	Sweet's syndrome with laryngoparalysis due to laryngitis. ( 29696681 )	Miyamura T....Ihn H.	2018
4	Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )	Wertz A....Zopf D.A.	2018
5	Spread of dystonia in patients with idiopathic adult-onset laryngeal dystonia. ( 29935029 )	Esposito M....Defazio G.	2018
6	Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )	Dunn A....Shalin S.C.	2018
7	Severe angioedema of laryngeal inlet in a woman receiving telmisartan therapy undergoing breast conservation surgery. ( 29910501 )	Behera B.K....Kar M.	2018
8	Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery. ( 29682274 )	Gurleyik E....Ipor A.	2018
9	Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )	Orita Y....Sato Y.	2018
10	Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor. ( 29423509 )	Patel P.N....Francis D.O.	2018
11	Correlation between bulbar functionality and laryngeal penetration and/or laryngotracheal aspiration on motor neuron disease. ( 29513871 )	BrandALo B.C....Silva R.G.D.	2018
12	Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )	Berzofsky C.E....Woodson G.	2018
13	Laryngeal cleft type IV: One pathology, two different presentations. ( 29728171 )	HernA!ndez G....GonzA!lez-Aquino C.	2018
14	Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany. ( 29725537 )	Kostev K....Seidel D.U.	2018
15	Eosinophilic granulomatosis with polyangiitis and laryngeal involvement: review of the literature and a cross-sectional prospective experience. ( 29888684 )	Seccia V....Baldini C.	2018
16	Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )	Ban M.J....Park J.H.	2018
17	Simple laryngeal suspension procedure by suturing the digastric muscle to the periosteum of the mandible in neck dissection for tongue cancer. ( 29395281 )	Ohkoshi A....Katori Y.	2018
18	Laryngeal ultrasound for the diagnosis of laryngomalacia in infants. ( 29405660 )	Friedman S....Sivan Y.	2018
19	Air- Q intubating laryngeal airway guided intubation in Morquio syndrome. ( 29962532 )	Mohammed S....Chouhan R.S.	2018
20	Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population-based study. ( 29412495 )	Hall S.F....Griffiths R.J.	2018
21	Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. ( 29443735 )	Yang C.W....Liu J.X.	2018
22	Tumor suppression effect of targeting periostin with siRNA in a nude mouse model of human laryngeal squamous cell carcinoma. ( 29978598 )	Ye D....Shen Z.	2018
23	Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. ( 29869750 )	Pandiar D....Babu S.	2018
24	Use of a national identification database to determine the lifetime prognosis in cattle with necrotic laryngitis and the predictive value of venous pCO<sub>2</sub>. ( 29968934 )	Pardon B....Deprez P.	2018
25	Development and validation of a quality of life instrument for patients with laryngeal cleft. ( 29605344 )	Irace A.L....Rahbar R.	2018
26	Classifying and Diagnosing Laryngeal Dystonia-Are We Artists or Are We Scientists? ( 29931264 )	Hillel A.D.	2018
27	Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. ( 29598944 )	Kamal M....Rosenthal D.I.	2018
28	Fibroblast growth factor receptor 1 amplification in laryngeal squamous cell carcinoma. ( 29351293 )	Monico J....Sullivan D.C.	2018
29	Laryngeal papillomatosis in Senegal: A ten-year experience. ( 29396224 )	MaA^ga S....Diouf R.	2018
30	Primary Laryngeal Tuberculosis: Our Experiences at a Tertiary Care Teaching Hospital in Eastern India. ( 29773323 )	Swain S.K....Sahu M.C.	2018
31	Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. ( 29017739 )	Geier J....Orlando B.	2018
32	Pulmonary melioidosis with laryngeal involvement: an unusual site of infection. ( 29374089 )	Ng C.L....Lee P.	2018
33	SWALLOWING IN PATIENTS WITH LARYNGITIS. ( 29561977 )	Moda I....Dantas R.O.	2018
34	Laryngeal tuberculosis: a rare cause of critical airway obstruction. ( 29348284 )	Cole A.E....Chekairi A.	2018
35	Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression. ( 29930164 )	Triplett J....Lucas M.	2018
36	Laryngeal Tuberculosis Mimicking Laryngeal Carcinoma on <sup>18</sup>F-FDG PET/CT Imaging. ( 29889030 )	Cengiz A....YA1rekli Y.	2018
37	Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )	Londahl M....Rahbar R.	2018
38	Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )	Cho J.H....Joo Y.H.	2018
39	CCL20/CCR6 promotes cell proliferation and metastasis in laryngeal cancer by activating p38 pathway. ( 27916417 )	Lu E....Wang Y.	2017
40	A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )	Qiu Y....Lei Y.	2017
41	[Pediatric laryngeal clefts: an experience in the diagnosis and management of 13 cases]. ( 28910893 )	Wu Z.B....Ma X.Y.	2017
42	The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone. ( 28475003 )	Wang M....Fan G.K.	2017
43	Factors Associated With Infectious Laryngitis: A Retrospective Review of 15 Cases. ( 28397557 )	Thomas C.M....Clary M.S.	2017
44	Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6. ( 28466560 )	Li S....Yang X.	2017
45	Downregulation of miRNA-26b inhibits cancer proliferation of laryngeal carcinoma through autophagy by targeting ULK2 and inactivation of the PTEN/AKT pathway. ( 28713931 )	Wang S....Li C.	2017
46	Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma. ( 28225775 )	Zhou J....Lu L.M.	2017
47	There is no correlation between signs of reflux laryngitis and reflux oesophagitis in patients with gastro-oesophageal reflux disease symptoms. ( 29165435 )	Zelenik K....Kominek P.	2017
48	WRAP53I^, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer. ( 28849066 )	TiefenbAPck-Hansson K....Roberg K.	2017
49	Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. ( 28910519 )	Boesch R.P....Balakrishnan K.	2017
50	Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. ( 28102032 )	Ben-Dayan M.M....Schlecht N.F.	2017

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Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HRH2	Histamine Receptor H2	Protein Coding	19.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	19.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	IL1B	Interleukin 1 Beta	Protein Coding	19.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	18.05	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	18.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	IL6	Interleukin 6	Protein Coding	16.85	GeneCards inferred via : Publications (show sections)
7	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	16.85	GeneCards inferred via : Publications (show sections)
8	FGF2	Fibroblast Growth Factor 2	Protein Coding	16.65	GeneCards inferred via : Publications (show sections)

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Variations for Laryngitis

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Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

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Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Super pathways	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer's disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington's disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ³⁷ Oxidative phosphorylation ¹ Parkinson's disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.38	ATP12A ATP4A IL1B IL6 TGFB1 TNF
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.36	FGF2 IL1B IL6 TGFB1 TNF
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.26	FGF2 IL1B IL6 TGFB1 TNF
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.21	FGF2 IL1B IL6 TGFB1 TNF
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.14	FGF2 IL1B IL6 TGFB1 TNF
6	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.88	IL1B IL6 TGFB1 TNF
7	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.76	IL1B IL6 TGFB1 TNF
8	MAPK signaling pathway ¹ ³⁷	12.63	FGF2 IL1B TGFB1 TNF
9	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.49	FGF2 IL1B IL6 TGFB1 TNF
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.47	FGF2 IL1B IL6 TNF
11	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.45	FGF2 IL6 TGFB1 TNF
12	Th17 cell differentiation ³⁷ Show member pathways Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.33	IL1B IL6 TGFB1 TNF
13	HTLV-I infection ³⁷	12.31	IL6 TGFB1 TNF
14	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.31	IL1B IL6 TGFB1 TNF
15	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.24	IL1B IL6 TNF
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.23	IL1B IL6 TNF
17	Proteoglycans in cancer ³⁷	12.2	FGF2 TGFB1 TNF
18	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.17	IL1B IL6 TNF
19	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.16	IL1B TGFB1 TNF
20	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.13	IL1B IL6 TNF
21	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 family signaling ⁶⁶ Interleukin-6 signaling ⁶⁶ Th17 Differentiation Pathway ⁶⁵	12.13	IL1B IL6 TGFB1 TNF
22	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.12	IL1B IL6 TNF
23	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.12	IL6 TGFB1 TNF
24	Tuberculosis ³⁷	12.1	IL1B IL6 TGFB1 TNF
25	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.09	IL1B IL6 TNF
26	Colorectal Cancer Metastasis ⁶⁴	12.08	IL6 TGFB1 TNF
27	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.08	IL1B IL6 TNF
28	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	12.06	FGF2 TGFB1 TNF
29	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.97	FGF2 IL6 TGFB1
30	Adipogenesis ¹	11.97	IL6 TGFB1 TNF
31	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.96	FGF2 IL1B IL6 TGFB1
32	Osteoclast differentiation ³⁷	11.95	IL1B TGFB1 TNF
33	TNF signaling pathway ³⁷	11.87	IL1B IL6 TNF
34	Senescence and Autophagy in Cancer ¹	11.86	IL1B IL6 TGFB1
35	Spinal Cord Injury ¹	11.84	IL1B IL6 TGFB1 TNF
36	Hematopoietic cell lineage ³⁷	11.81	IL1B IL6 TNF
37	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.73	IL1B IL6 TGFB1 TNF
38	Amoebiasis ³⁷	11.69	IL1B IL6 TGFB1 TNF
39	Pertussis ³⁷	11.68	IL1B IL6 TNF
40	Rheumatoid arthritis ³⁷	11.62	IL1B IL6 TGFB1 TNF
41	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.59	IL1B IL6 TNF
42	Legionellosis ³⁷	11.51	IL1B IL6 TNF
43	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.49	IL1B IL6 TGFB1 TNF
44	Interleukin-10 signaling ⁶⁶	11.46	IL1B IL6 TNF
45	Aryl Hydrocarbon Receptor Pathway ¹	11.44	IL1B TGFB1 TNF
46	Differentiation Pathway ¹	11.43	FGF2 IL6 TGFB1
47	Interleukin-4 and 13 signaling ⁶⁶	11.41	FGF2 IL1B IL6 TGFB1 TNF
48	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.4	IL1B IL6 TNF
49	Prion diseases ³⁷	11.27	IL1B IL6
50	African trypanosomiasis ³⁷	11.26	IL1B IL6 TNF

Sources

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.1	ATP4A FGF2 IL1B IL6 TGFB1 TNF

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.96	FGF2 IL1B IL6 TGFB1
2	immune response	GO:0006955	9.95	HRH2 IL1B IL6 TNF
3	inflammatory response	GO:0006954	9.91	IL1B IL6 TGFB1 TNF
4	positive regulation of gene expression	GO:0010628	9.9	IL1B IL6 TGFB1 TNF
5	positive regulation of transcription, DNA-templated	GO:0045893	9.89	FGF2 IL1B IL6 TGFB1 TNF
6	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.88	FGF2 TGFB1 TNF
7	leukocyte migration	GO:0050900	9.87	IL1B TGFB1 TNF
8	positive regulation of protein phosphorylation	GO:0001934	9.85	IL1B TGFB1 TNF
9	positive regulation of protein kinase B signaling	GO:0051897	9.84	FGF2 TGFB1 TNF
10	MAPK cascade	GO:0000165	9.84	FGF2 IL1B TGFB1 TNF
11	activation of MAPK activity	GO:0000187	9.79	FGF2 IL1B TNF
12	positive regulation of DNA binding transcription factor activity	GO:0051091	9.79	IL1B IL6 TNF
13	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.74	IL6 TGFB1 TNF
14	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.73	IL1B TNF
15	cellular response to organic cyclic compound	GO:0071407	9.73	IL1B TGFB1 TNF
16	digestive tract development	GO:0048565	9.72	HRH2 TGFB1
17	negative regulation of blood vessel endothelial cell migration	GO:0043537	9.72	FGF2 TGFB1
18	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	9.72	FGF2 TNF
19	potassium ion import	GO:0010107	9.72	ATP12A ATP4A
20	regulation of angiogenesis	GO:0045765	9.72	FGF2 IL6
21	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.71	IL1B TNF
22	positive regulation of phagocytosis	GO:0050766	9.71	IL1B TNF
23	negative regulation of mitotic cell cycle	GO:0045930	9.71	TGFB1 TNF
24	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.71	IL1B TNF
25	osteoclast differentiation	GO:0030316	9.7	TGFB1 TNF
26	ATP hydrolysis coupled proton transport	GO:0015991	9.7	ATP12A ATP4A
27	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.7	FGF2 TGFB1
28	protein import into nucleus, translocation	GO:0000060	9.7	TGFB1 TNF
29	positive regulation of MAP kinase activity	GO:0043406	9.7	FGF2 TGFB1 TNF
30	positive regulation of interleukin-8 production	GO:0032757	9.69	IL1B TNF
31	positive regulation of vascular endothelial growth factor production	GO:0010575	9.69	IL1B TGFB1
32	positive regulation of protein complex assembly	GO:0031334	9.68	TGFB1 TNF
33	negative regulation of myoblast differentiation	GO:0045662	9.68	TGFB1 TNF
34	positive regulation of chemokine production	GO:0032722	9.68	IL6 TNF
35	positive regulation of histone acetylation	GO:0035066	9.68	IL1B TGFB1
36	cellular sodium ion homeostasis	GO:0006883	9.67	ATP12A ATP4A
37	negative regulation of lipid catabolic process	GO:0050995	9.66	IL1B TNF
38	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.65	IL1B TNF
39	hyaluronan catabolic process	GO:0030214	9.65	FGF2 TGFB1
40	positive regulation of interleukin-6 production	GO:0032755	9.65	IL1B IL6 TNF
41	cellular potassium ion homeostasis	GO:0030007	9.64	ATP12A ATP4A
42	sodium ion export across plasma membrane	GO:0036376	9.64	ATP12A ATP4A
43	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.63	ATP12A ATP4A
44	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.62	IL1B TNF
45	negative regulation of lipid storage	GO:0010888	9.59	IL6 TNF
46	positive regulation of chemokine biosynthetic process	GO:0045080	9.58	IL1B TNF
47	regulation of establishment of endothelial barrier	GO:1903140	9.58	IL1B TNF
48	positive regulation of cell division	GO:0051781	9.58	FGF2 IL1B TGFB1
49	positive regulation of fever generation	GO:0031622	9.55	IL1B TNF
50	regulation of signaling receptor activity	GO:0010469	9.55	FGF2 IL1B IL6 TGFB1 TNF

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.43	FGF2 IL6 TGFB1
2	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP12A ATP4A
3	cytokine activity	GO:0005125	9.02	FGF2 IL1B IL6 TGFB1 TNF
4	potassium:proton exchanging ATPase activity	GO:0008900	8.96	ATP12A ATP4A

Sources

Sources for Laryngitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Laryngitis

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Classifications:

External Ids:

Summaries for Laryngitis

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Laryngitis:

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

MGI Mouse Phenotypes related to Laryngitis:

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

Publications for Laryngitis

Articles related to Laryngitis:

Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

Variations for Laryngitis

Expression for Laryngitis

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

Sources for Laryngitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :