Laryngitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRY019 MIFTS: 54	Laryngitis Categories: Infectious diseases, Oral diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis ¹² ⁴⁴ ¹⁵ ⁷³

Acute Laryngitis ⁷³

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3437

MeSH ⁴⁴ D007827

NCIt ⁵⁰ C26811

SNOMED-CT ⁶⁸ 45913009

UMLS ⁷³ C0023067 C0001327

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Summaries for Laryngitis

Disease Ontology : ¹² A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and laryngeal disease, and has symptoms including throat irritation An important gene associated with Laryngitis is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and TGF-Beta Pathway. The drugs Fluticasone and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and lung, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : ⁷⁶ Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

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Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis	Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 909)

#	Related Disease	Score	Top Affiliating Genes
1	acute laryngitis	33.5	ATP12A ATP4A
2	laryngeal disease	33.5	ATP12A ATP4A
3	chronic laryngitis	33.3	ATP12A ATP4A HRH2
4	laryngeal tuberculosis	33.3	ATP12A ATP4A
5	lateral medullary syndrome	31.4	ATP12A ATP4A
6	pneumonia	30.1	IL1B IL6 TNF
7	sudden infant death syndrome	30.0	IL1B IL6 TNF
8	aspiration pneumonia	29.9	ATP12A ATP4A
9	viral infectious disease	29.9	IL1B IL6 TNF
10	acquired immunodeficiency syndrome	29.9	IL1B IL6 TNF
11	apnea, obstructive sleep	29.8	IL6 TNF
12	arthritis	29.8	IL1B IL6 TGFB1 TNF
13	paraneoplastic syndromes	29.8	IL1B IL6
14	sleep apnea	29.8	IL1B IL6 TNF
15	leishmaniasis	29.7	IL1B IL6 TGFB1 TNF
16	rheumatoid arthritis	29.6	IL1B IL6 TGFB1 TNF
17	hematopoietic stem cell transplantation	29.6	IL6 TNF
18	pertussis	29.6	IL1B IL6 TNF
19	burns	29.6	IL1B TNF
20	myeloma, multiple	29.5	FGF2 IL6 TNF
21	esophagitis	29.5	HRH2 IL1B IL6 TGFB1
22	myelitis	29.5	IL6 TNF
23	aphthous stomatitis	29.5	IL1B IL6 TNF
24	gastroenteritis	29.5	IL1B IL6 TNF
25	spinal cord injury	29.3	IL6 TGFB1 TNF
26	lung disease	29.3	IL1B IL6 TGFB1 TNF
27	pulmonary disease, chronic obstructive	29.3	IL6 TGFB1 TNF
28	silicosis	29.3	IL1B TGFB1 TNF
29	esophagitis, eosinophilic, 1	29.3	ATP12A ATP4A
30	adult-onset still's disease	29.3	IL1B IL6 TNF
31	aspiration pneumonitis	29.3	ATP12A ATP4A HRH2
32	acute respiratory distress syndrome	29.3	IL1B IL6 TNF
33	pericarditis	29.2	IL1B IL6 TNF
34	tonsillitis	29.2	IL1B IL6 TNF
35	lyme disease	29.2	IL1B IL6 TNF
36	graft-versus-host disease	29.2	IL1B IL6 TNF
37	cerebral palsy	29.2	IL1B IL6 TNF
38	inflammatory bowel disease	29.1	IL1B IL6 TGFB1 TNF
39	hernia, hiatus	29.1	ATP12A ATP4A
40	asthma	29.1	HRH2 IL1B IL6 TGFB1 TNF
41	peptic esophagitis	28.6	ATP12A ATP4A HRH2 IL1B
42	laryngeal papillomatosis	12.5
43	laryngeal cleft	12.4
44	laryngeal web, familial	12.4
45	laryngeal squamous cell carcinoma	12.4
46	viral laryngitis	12.3
47	congenital laryngeal palsy	12.2
48	larynx cancer	12.2
49	laryngeal cartilage cancer	12.1
50	laryngeal abductor paralysis	12.1

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Bronchitis
Deficiency Anemia	Esophagitis
Heart Disease	Hypertension, Essential
Ischemic Heart Disease	Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:

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Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

throat irritation

MGI Mouse Phenotypes related to Laryngitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.63	ATP12A ATP4A HRH2 IL6 TGFB1 TNF
2	homeostasis/metabolism	MP:0005376	9.56	ATP12A ATP4A FGF2 HRH2 IL1B IL6
3	neoplasm	MP:0002006	9.1	ATP4A FGF2 IL1B IL6 TGFB1 TNF

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Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fluticasone

Approved, Experimental

Phase 4,Phase 3

90566-53-3

62924

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

73590-58-6

4594

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

50-02-2

5743

Racepinephrine

Approved

Phase 4,Not Applicable

329-65-7

838

Epinephrine

Approved, Vet_approved

Phase 4,Not Applicable

51-43-4

5816

Esomeprazole

Approved, Investigational

Phase 4

161796-78-7, 119141-88-7

4594 9579578

Meloxicam

Approved, Vet_approved

Phase 4

71125-38-7

54677470 5281106

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Dexlansoprazole

Approved, Investigational

Phase 4

103577-45-3, 138530-94-6

9578005

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Hormone Antagonists

Phase 4,Phase 3,Not Applicable

glucocorticoids

Phase 4,Phase 3,Not Applicable

Salmeterol xinafoate

Phase 4

94749-08-3

56801

Adrenergic beta-Agonists

Phase 4

Fluticasone Propionate, Salmeterol Xinafoate Drug Combination

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3

Adrenergic Agents

Phase 4,Phase 2,Phase 3

Autonomic Agents

Phase 4,Phase 3,Not Applicable

Hormones

Phase 4,Phase 2,Phase 3,Not Applicable

Anti-Allergic Agents

Phase 4,Phase 3

Respiratory System Agents

Phase 4,Phase 3,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 3,Not Applicable

Dermatologic Agents

Phase 4,Phase 3

Bronchodilator Agents

Phase 4,Phase 3,Not Applicable

Sympathomimetics

Phase 4

Adrenergic beta-2 Receptor Agonists

Phase 4

Adrenergic Agonists

Phase 4

Proton Pump Inhibitors

Phase 4,Phase 2,Phase 3,Not Applicable

Gastrointestinal Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Not Applicable

BB 1101

Phase 4,Not Applicable

HIV Protease Inhibitors

Phase 4,Not Applicable

Antiemetics

Phase 4,Phase 3,Not Applicable

protease inhibitors

Phase 4,Not Applicable

Epinephryl borate

Phase 4,Not Applicable

Anti-Ulcer Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Antacids

Phase 4,Phase 2,Phase 3,Not Applicable

Analgesics

Phase 4,Phase 2,Phase 3

Analgesics, Non-Narcotic

Phase 4,Phase 2,Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Antirheumatic Agents

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Vasoconstrictor Agents

Phase 4

Mydriatics

Phase 4

Adrenergic alpha-Agonists

Phase 4

Interventional clinical trials:

(show all 39)

#	Name	Status	NCT ID	Phase	Drugs
1	Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID	Unknown status	NCT00235053	Phase 4	fluticasone/salmeterol DISKUS 250/50
2	Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux	Completed	NCT00628667	Phase 4	Esomeprazole;Placebo
3	Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis	Completed	NCT02229747	Phase 4	Meloxicam;Diclofenac;Nimesulide
4	Quality of Life Validation in Laryngitis	Completed	NCT00641264	Phase 4	Omeprazole
5	Community Care for Croup (RCT)	Completed	NCT01042145	Phase 4	Prednisone;Dexamethasone
6	The Effect and Safety of Low Dose Nebulized Epinephrine in Croup	Recruiting	NCT01664507	Phase 4	conventional dose epinephrine;low dose epinephrine
7	Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup	Recruiting	NCT03705273	Phase 4	Dexamethasone IV for PO;Dexamethasone crushed tablets
8	Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux	Terminated	NCT00369265	Phase 4	Lansoprazole
9	Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias	Unknown status	NCT01408108	Phase 3
10	Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh	Unknown status	NCT01780285	Phase 3
11	Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants	Unknown status	NCT01249911	Phase 3
12	Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment	Completed	NCT00204698	Phase 2, Phase 3	Aciphex
13	CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study	Completed	NCT01948856	Phase 3	J022X ST;Placebo
14	Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial	Completed	NCT01304927	Phase 2, Phase 3	Cholecalciferol and calcium
15	E. Coli Nissle 1917 - Suspension for Infection Prophylaxis	Active, not recruiting	NCT02802059	Phase 3	EcN-Suspension;Placebo
16	Treatment of Chronic Laryngitis With Amitriptyline	Suspended	NCT02552225	Phase 2, Phase 3	Amitriptyline
17	Trial of the Treatment of Chronic Laryngitis With Amitryptiline	Terminated	NCT02434523	Phase 2, Phase 3	Amitriptyline
18	Management of Recurrent Croup	Terminated	NCT01748162	Phase 3	Fluticasone;Prednisolone IF needed
19	Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup	Terminated	NCT00938353	Phase 3	beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
20	Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants	Completed	NCT00611390	Phase 1, Phase 2
21	Comparing Different Ways of Delivering Humidity to Children With Croup	Completed	NCT00230841	Phase 2
22	A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants	Completed	NCT00686075	Phase 1, Phase 2
23	A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children	Completed	NCT00767416	Phase 1, Phase 2
24	Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age	Completed	NCT00493285	Phase 1
25	Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR	Unknown status	NCT01755221	Not Applicable
26	Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children	Unknown status	NCT02056379	Not Applicable	Budesonide;Dexamethasone
27	Intestinal Microbiota Composition After Antibiotic Treatment in Early Life	Unknown status	NCT02536560
28	Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis	Completed	NCT01806220	Not Applicable
29	Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis	Completed	NCT01389401		omeprazole
30	Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients	Completed	NCT00517114	Not Applicable	Rabeprazole 20mg twice daily
31	Non Interventional Study (NIS) Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis	Completed	NCT02160912
32	Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists	Completed	NCT02048449
33	Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)	Completed	NCT01406275		Amoxicillin and clavulanate
34	Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments	Completed	NCT01767064	Not Applicable
35	The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold	Completed	NCT03309995	Not Applicable
36	A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children	Completed	NCT00626808		No Intervention
37	Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children.	Completed	NCT01861548
38	Repeated Versus Varied Simulation Scenarios to Teach Medical Students the Management of a Pediatric Asthma Exacerbation	Completed	NCT02754310	Not Applicable
39	A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup	Terminated	NCT00147849	Not Applicable

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

guaifenesin

Cochrane evidence based reviews: laryngitis

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Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

⁴¹

Testes, Heart, Lung, Skin, Bone, Thyroid, Myeloid

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Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 422)

#	Title	Authors	Year
1	Sweet's syndrome with laryngoparalysis due to laryngitis. ( 29696681 )	Miyamura T....Ihn H.	2018
2	Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )	Ban M.J....Park J.H.	2018
3	Use of a national identification database to determine the lifetime prognosis in cattle with necrotic laryngitis and the predictive value of venous pCO<sub>2</sub>. ( 29968934 )		2018
4	SWALLOWING IN PATIENTS WITH LARYNGITIS. ( 29561977 )		2018
5	Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease? ( 30297197 )	Su?rez-D?az S...Caminal-Montero L	2018
6	Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )	Cho JH...Joo YH	2018
7	Herpes simplex laryngitis presenting as airway obstruction in a stroke patient. ( 30186766 )	Pradeep T...Zhang J	2018
8	Characteristics and Voice Outcomes of Ulcerative Laryngitis. ( 30170913 )	Young VN...Rosen CA	2018
9	Acute infectious laryngitis: A case series. ( 30273430 )	Jaworek AJ...Sataloff RT	2018
10	Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study. ( 30535974 )	Lou Z...Jiang JJ	2018
11	Factors Associated With Infectious Laryngitis: A Retrospective Review of 15 Cases. ( 28397557 )	Thomas C.M....Clary M.S.	2017
12	There is no correlation between signs of reflux laryngitis and reflux oesophagitis in patients with gastro-oesophageal reflux disease symptoms. ( 29165435 )	Zelenik K....Kominek P.	2017
13	TNF-I+ inhibitor as a cause of refractory suppurative laryngitis and rhinosinusitis. ( 28931201 )	Akbulut S....Rosen C.A.	2017
14	<i>Saccharomyces cerevisiae</i> Laryngitis and Oral Lesions in a Patient with Laryngeal Carcinoma. ( 29318065 )	Algazaq J.N....Bharti A.R.	2017
15	MRSA chronic bacterial laryngitis: A growing problem. ( 29086424 )	Carpenter P.S....Kendall K.A.	2017
16	Allergic laryngitis: unraveling the myths. ( 28266945 )		2017
17	Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction: A Case Report and Literature Review. ( 28397560 )		2017
18	Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )	Yang Y....Zhou J.	2016
19	Pulsed dye laser treatment of primary cryptococcal laryngitis: A novel approach to an uncommon disease. ( 27654751 )	Ihenachor E.J....Chhetri D.	2016
20	Herpes zoster laryngitis in a patient treated with fingolimod. ( 27553068 )	Hagiya H....Tomono K.	2016
21	Laryngitis obscuring an anterior glottic mass. ( 26829678 )		2016
22	Finnish guidelines for the treatment of laryngitis, wheezing bronchitis and bronchiolitis in children. ( 26295564 )	Tapiainen T...Korppi M	2016
23	Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial. ( 27126336 )	M?ller D...M?sges R	2016
24	What Role Does Allergy Play in Chronic Ear Disease and Laryngitis? ( 27783318 )	Platt MP...Krouse JH	2016
25	Subglottic laryngitis--Changes in therapy approach over the past 20 years. ( 25921270 )	PeneziA8 A....Baudoin T.	2015
26	Viral laryngitis: a mimic and a monster - range, presentation, management. ( 26397458 )	Dominguez L.M....Simpson C.B.	2015
27	Utility of Allergy Testing in Patients with Chronic Laryngopharyngeal Symptoms: Is It Allergic Laryngitis? ( 26428475 )	Brook C.D....Noordzij J.P.	2015
28	The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )	Kinnari T.J.	2015
29	Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )	Kim C.S....Joo Y.H.	2015
30	Ramsay Hunt syndrome and zoster laryngitis with multiple cranial nerve involvement. ( 26793453 )	Shinha T....Krishna P.	2015
31	Idiopathic Ulcerative Laryngitis: An uncommon disease. ( 26748984 )	Valls M....Vilaseca I.	2015
32	Eosinophilic Laryngitis in Children with Aerodigestive Dysfunction. ( 25820587 )		2015
33	Antibiotics for acute laryngitis in adults. ( 26002823 )		2015
34	1263: A CASE OF LARYNGITIS CAUSED BY AN UNUSUAL SUSPECT. ( 26570924 )		2015
35	Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )		2015
36	Proliferative laryngitis with airway obstruction in an adult: Consider herpes. ( 26297873 )		2015
37	Candida laryngitis appearing as carcinoma. ( 26644902 )		2015
38	Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model. ( 26197967 )		2015
39	Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )		2015
40	Cryptococcal laryngitis: An uncommon presentation of a common pathogen. ( 26636155 )		2015
41	Reflux Laryngitis: Correlation between the Symptoms Findings and Indirect Laryngoscopy. ( 26157498 )	Silva CE...Portinho F	2015
42	Salivary transforming growth factor alpha in patients with SjAPgren's syndrome and reflux laryngitis. ( 25457064 )	Corvo M.A....Bussoloti Filho I.	2014
43	Human laryngitis caused by Clinostomum complanatum. ( 25130004 )	Hara H....Yamashita H.	2014
44	Severe candida laryngitis in a patient with rheumatoid arthritis treated with adalimumab. ( 27708907 )	Kobak A.9....A9A9retmen Z.	2014
45	Fungal laryngitis in immunocompetent patients. ( 24533421 )	Ravikumar A....Sudhir B.	2014
46	Current perspectives on reflux laryngitis. ( 25491904 )	Asaoka D....Watanabe S.	2014
47	Laryngitis. ( 25300640 )	Wood J.M....Allen J.	2014
48	Effects of reflux laryngitis on non-nutritive swallowing in newborn lambs. ( 24893350 )	Brisebois S....Praud J.P.	2014
49	Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study. ( 23613090 )	Marinho R.R....Thomazzi S.M.	2014
50	Detection of Chronic Laryngitis due to Laryngopharyngeal Reflux Using Color and Texture Analysis of Laryngoscopic Images. ( 24314831 )		2014

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Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HRH2	Histamine Receptor H2	Protein Coding	19.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	19.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	IL1B	Interleukin 1 Beta	Protein Coding	19.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	18.02	DISEASES inferred ¹⁵
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	18.02	DISEASES inferred ¹⁵
6	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	16.77	GeneCards inferred via : Publications (show sections)
7	IL6	Interleukin 6	Protein Coding	16.77	GeneCards inferred via : Publications (show sections)
8	FGF2	Fibroblast Growth Factor 2	Protein Coding	16.56	GeneCards inferred via : Publications (show sections)

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Variations for Laryngitis

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Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

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Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Super pathways	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ³⁷ Oxidative phosphorylation ¹ Parkinson disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.4	ATP12A ATP4A IL1B IL6 TGFB1 TNF
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.38	FGF2 IL1B IL6 TGFB1 TNF
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.27	FGF2 IL1B IL6 TGFB1 TNF
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.22	FGF2 IL1B IL6 TGFB1 TNF
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.16	FGF2 IL1B IL6 TGFB1 TNF
6	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	12.92	FGF2 IL1B IL6 TGFB1 TNF
7	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.89	IL1B IL6 TGFB1 TNF
8	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.77	IL1B IL6 TGFB1 TNF
9	MAPK signaling pathway ³⁷ ¹	12.65	FGF2 IL1B TGFB1 TNF
10	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.54	FGF2 IL1B IL6 TGFB1 TNF
11	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.49	IL1B IL6 TGFB1 TNF
12	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.48	FGF2 IL1B IL6 TNF
13	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.34	IL1B IL6 TGFB1 TNF
14	Human T-cell leukemia virus 1 infection ³⁷	12.32	IL6 TGFB1 TNF
15	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.24	IL1B IL6 TNF
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.24	IL1B IL6 TNF
17	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.22	FGF2 IL1B IL6 TNF
18	Proteoglycans in cancer ³⁷	12.21	FGF2 TGFB1 TNF
19	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.17	IL1B TGFB1 TNF
20	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.14	IL1B IL6 TNF
21	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.13	IL1B IL6 TNF
22	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.13	IL6 TGFB1 TNF
23	Tuberculosis ³⁷	12.13	IL1B IL6 TGFB1 TNF
24	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.1	IL1B IL6 TNF
25	Colorectal Cancer Metastasis ⁶⁴	12.1	IL6 TGFB1 TNF
26	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.09	IL1B IL6 TNF
27	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	12.08	FGF2 TGFB1 TNF
28	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.08	FGF2 IL1B IL6 TGFB1 TNF
29	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.99	FGF2 IL6 TGFB1
30	Adipogenesis ¹	11.98	IL6 TGFB1 TNF
31	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.97	FGF2 IL1B IL6 TGFB1
32	Osteoclast differentiation ³⁷	11.96	IL1B TGFB1 TNF
33	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	11.95	IL1B IL6 TNF
34	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.93	IL1B IL6 TGFB1 TNF
35	TNF signaling pathway ³⁷	11.89	IL1B IL6 TNF
36	Senescence and Autophagy in Cancer ¹	11.87	IL1B IL6 TGFB1
37	Spinal Cord Injury ¹	11.87	IL1B IL6 TGFB1 TNF
38	Hematopoietic cell lineage ³⁷	11.83	IL1B IL6 TNF
39	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.75	IL1B IL6 TGFB1 TNF
40	Amoebiasis ³⁷	11.72	IL1B IL6 TGFB1 TNF
41	Pertussis ³⁷	11.7	IL1B IL6 TNF
42	Rheumatoid arthritis ³⁷	11.66	IL1B IL6 TGFB1 TNF
43	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.61	IL1B IL6 TNF
44	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.54	IL1B IL6 TGFB1 TNF
45	Legionellosis ³⁷	11.53	IL1B IL6 TNF
46	Interleukin-10 signaling ⁶⁶	11.48	IL1B IL6 TNF
47	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.47	IL1B IL6 TGFB1 TNF
48	Aryl Hydrocarbon Receptor Pathway ¹	11.46	IL1B TGFB1 TNF
49	Differentiation Pathway ¹	11.46	FGF2 IL6 TGFB1
50	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.42	IL1B IL6 TNF

Sources

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.1	ATP4A FGF2 IL1B IL6 TGFB1 TNF

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.99	FGF2 IL1B IL6 TGFB1
2	immune response	GO:0006955	9.97	HRH2 IL1B IL6 TNF
3	positive regulation of gene expression	GO:0010628	9.95	IL1B IL6 TGFB1 TNF
4	inflammatory response	GO:0006954	9.93	IL1B IL6 TGFB1 TNF
5	positive regulation of transcription, DNA-templated	GO:0045893	9.93	FGF2 IL1B IL6 TGFB1 TNF
6	leukocyte migration	GO:0050900	9.89	IL1B TGFB1 TNF
7	positive regulation of protein phosphorylation	GO:0001934	9.88	IL1B TGFB1 TNF
8	positive regulation of protein kinase B signaling	GO:0051897	9.87	FGF2 TGFB1 TNF
9	cellular response to lipopolysaccharide	GO:0071222	9.87	IL1B IL6 TNF
10	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.85	FGF2 IL1B TGFB1 TNF
11	activation of MAPK activity	GO:0000187	9.83	FGF2 IL1B TNF
12	MAPK cascade	GO:0000165	9.83	FGF2 IL1B TGFB1 TNF
13	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.82	IL1B IL6 TNF
14	wound healing	GO:0042060	9.8	FGF2 IL1B TGFB1
15	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.79	IL6 TGFB1 TNF
16	cellular response to organic cyclic compound	GO:0071407	9.78	IL1B TGFB1 TNF
17	response to glucocorticoid	GO:0051384	9.77	IL1B IL6 TNF
18	regulation of signaling receptor activity	GO:0010469	9.77	FGF2 IL1B IL6 TGFB1 TNF
19	positive regulation of MAP kinase activity	GO:0043406	9.76	FGF2 TGFB1 TNF
20	positive regulation of interleukin-6 production	GO:0032755	9.75	IL1B IL6 TNF
21	negative regulation of blood vessel endothelial cell migration	GO:0043537	9.74	FGF2 TGFB1
22	positive regulation of JUN kinase activity	GO:0043507	9.74	IL1B TNF
23	potassium ion import across plasma membrane	GO:1990573	9.74	ATP12A ATP4A
24	positive regulation of phagocytosis	GO:0050766	9.74	IL1B TNF
25	potassium ion import	GO:0010107	9.73	ATP12A ATP4A
26	regulation of angiogenesis	GO:0045765	9.73	FGF2 IL6
27	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.73	IL1B TNF
28	negative regulation of mitotic cell cycle	GO:0045930	9.73	TGFB1 TNF
29	digestive tract development	GO:0048565	9.73	HRH2 TGFB1
30	osteoclast differentiation	GO:0030316	9.73	TGFB1 TNF
31	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.72	FGF2 TGFB1
32	ATP hydrolysis coupled proton transport	GO:0015991	9.72	ATP12A ATP4A
33	positive regulation of interleukin-8 production	GO:0032757	9.72	IL1B TNF
34	positive regulation of vascular endothelial growth factor production	GO:0010575	9.72	IL1B TGFB1
35	negative regulation of myoblast differentiation	GO:0045662	9.72	TGFB1 TNF
36	positive regulation of protein complex assembly	GO:0031334	9.71	TGFB1 TNF
37	response to immobilization stress	GO:0035902	9.71	IL1B TGFB1
38	protein import into nucleus, translocation	GO:0000060	9.71	TGFB1 TNF
39	positive regulation of chemokine production	GO:0032722	9.7	IL6 TNF
40	response to vitamin D	GO:0033280	9.7	IL1B TGFB1
41	positive regulation of histone acetylation	GO:0035066	9.7	IL1B TGFB1
42	cellular sodium ion homeostasis	GO:0006883	9.69	ATP12A ATP4A
43	negative regulation of lipid catabolic process	GO:0050995	9.68	IL1B TNF
44	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.68	IL1B TNF
45	hyaluronan catabolic process	GO:0030214	9.68	FGF2 TGFB1
46	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.68	IL1B TNF
47	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.67	ATP12A ATP4A
48	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.67	IL1B TNF
49	cellular potassium ion homeostasis	GO:0030007	9.66	ATP12A ATP4A
50	sodium ion export across plasma membrane	GO:0036376	9.65	ATP12A ATP4A

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.43	FGF2 IL6 TGFB1
2	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP12A ATP4A
3	cytokine activity	GO:0005125	9.02	FGF2 IL1B IL6 TGFB1 TNF
4	potassium:proton exchanging ATPase activity	GO:0008900	8.96	ATP12A ATP4A

Sources

Sources for Laryngitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Laryngitis

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Classifications:

External Ids:

Summaries for Laryngitis

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Laryngitis:

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

MGI Mouse Phenotypes related to Laryngitis:

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

Publications for Laryngitis

Articles related to Laryngitis:

Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

Variations for Laryngitis

Expression for Laryngitis

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

Sources for Laryngitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :