MCID: LRY019
MIFTS: 56

Laryngitis

Categories: Respiratory diseases, Infectious diseases

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 12 44 15 73
Acute Laryngitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3437
MeSH 44 D007827
NCIt 50 C26811
SNOMED-CT 68 45913009
UMLS 73 C0023067

Summaries for Laryngitis

Disease Ontology : 12 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and laryngeal disease, and has symptoms including throat irritation An important gene associated with Laryngitis is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and TGF-Beta Pathway. The drugs Omeprazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thyroid and lung, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 76 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 783)
# Related Disease Score Top Affiliating Genes
1 acute laryngitis 33.4 ATP12A ATP4A
2 laryngeal disease 33.0 ATP12A ATP4A
3 laryngeal tuberculosis 33.0 ATP12A ATP4A
4 chronic laryngitis 32.4 ATP12A ATP4A HRH2
5 burns 30.0 IL1B TNF
6 pneumonia 30.0 IL1B IL6 TNF
7 apnea, obstructive sleep 29.9 IL6 TNF
8 esophagitis 29.9 HRH2 IL1B IL6
9 myelitis 29.9 IL6 TNF
10 acquired immunodeficiency syndrome 29.7 IL1B IL6 TNF
11 sudden infant death syndrome 29.7 IL1B IL6 TNF
12 aspiration pneumonia 29.6 ATP12A ATP4A
13 pertussis 29.6 IL1B IL6 TNF
14 arthritis 29.6 IL1B IL6 TNF
15 spinal cord injury 29.5 IL6 TGFB1 TNF
16 paracoccidioidomycosis 29.5 IL6 TNF
17 tonsillitis 29.5 IL1B IL6 TNF
18 gastroenteritis 29.5 IL1B IL6 TNF
19 pulmonary disease, chronic obstructive 29.4 IL6 TGFB1 TNF
20 lung disease 29.3 IL1B TGFB1 TNF
21 duodenitis 29.3 ATP12A ATP4A
22 aphthous stomatitis 29.3 IL1B IL6 TNF
23 pericarditis 29.2 IL1B IL6 TNF
24 gingivitis 29.2 IL1B IL6 TNF
25 peritonitis 29.2 IL1B IL6 TNF
26 graft-versus-host disease 29.2 IL1B IL6 TNF
27 silicosis 29.2 IL1B TGFB1 TNF
28 prostatitis 29.1 IL1B IL6 TGFB1 TNF
29 hernia, hiatus 29.0 ATP12A ATP4A
30 rheumatoid arthritis 29.0 IL1B IL6 TGFB1 TNF
31 esophagitis, eosinophilic, 1 28.8 ATP12A ATP4A
32 aspiration pneumonitis 28.4 ATP12A ATP4A HRH2
33 paine syndrome 28.2 ATP12A ATP4A IL1B
34 asthma 27.7 HRH2 IL1B IL6 TGFB1 TNF
35 laryngeal papillomatosis 12.3
36 laryngeal cleft 12.3
37 laryngeal web, familial 12.2
38 viral laryngitis 12.1
39 congenital laryngeal palsy 12.1
40 larynx cancer 12.1
41 laryngeal cartilage cancer 12.0
42 laryngeal abductor paralysis 12.0
43 laryngeal small cell carcinoma 12.0
44 supraglottic laryngeal cancer 11.9
45 laryngeal adenoid cystic carcinoma 11.9
46 laryngeal mucoepidermoid carcinoma 11.9
47 laryngeal adductor paralysis 11.9
48 congenital laryngeal cyst 11.9
49 laryngeal atresia, encephalocele, and limb deformities 11.9
50 hirschsprung disease with heart defects, laryngeal anomalies, and preaxial polydactyly 11.8

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Ischemic Heart Disease Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:


throat irritation

MGI Mouse Phenotypes related to Laryngitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 ATP12A ATP4A HRH2 IL6 TGFB1 TNF
2 homeostasis/metabolism MP:0005376 9.56 ATP12A ATP4A FGF2 HRH2 IL1B IL6
3 neoplasm MP:0002006 9.02 FGF2 IL1B IL6 TGFB1 TNF

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
3
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
4
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3 90566-53-3 62924
5
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
6
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
7
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
8
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
11
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
12
Salmeterol xinafoate Phase 4 94749-08-3 56801
13 Dexamethasone acetate Phase 4,Not Applicable 1177-87-3
14 glucocorticoids Phase 4,Phase 3,Not Applicable
15
protease inhibitors Phase 4,Not Applicable
16 Respiratory System Agents Phase 4,Phase 3,Not Applicable
17 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
18 Adrenergic Agents Phase 4,Phase 2,Phase 3
19 Adrenergic Agonists Phase 4
20 Adrenergic beta-2 Receptor Agonists Phase 4
21 Adrenergic beta-Agonists Phase 4
22 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
24 HIV Protease Inhibitors Phase 4,Not Applicable
25 Hormone Antagonists Phase 4,Phase 3,Not Applicable
26 Dermatologic Agents Phase 4,Phase 3
27 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
28 Anti-Allergic Agents Phase 4,Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
30 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
32 Epinephryl borate Phase 4,Not Applicable
33 Antiemetics Phase 4,Phase 3,Not Applicable
34 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
35 Proton Pump Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
36 BB 1101 Phase 4,Not Applicable
37 Autonomic Agents Phase 4,Phase 3,Not Applicable
38 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
39 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
40 Analgesics Phase 4,Phase 2,Phase 3
41 Cyclooxygenase Inhibitors Phase 4
42 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
43 Antacids Phase 4,Phase 2,Phase 3,Not Applicable
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Not Applicable
46 Antirheumatic Agents Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Mydriatics Phase 4
49 Vasoconstrictor Agents Phase 4
50
Silicon Approved, Investigational Phase 3 7440-21-3 4082203

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
3 Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
4 Quality of Life Validation in Laryngitis Completed NCT00641264 Phase 4 Omeprazole
5 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
6 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
7 Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux Terminated NCT00369265 Phase 4 Lansoprazole
8 Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias Unknown status NCT01408108 Phase 3
9 Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh Unknown status NCT01780285 Phase 3
10 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
11 Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
12 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
13 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
14 E. Coli Nissle 1917 - Suspension for Infection Prophylaxis Recruiting NCT02802059 Phase 3 EcN-Suspension;Placebo
15 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
16 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
17 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
18 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
19 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants Completed NCT00611390 Phase 1, Phase 2
20 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
21 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
22 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children Completed NCT00767416 Phase 1, Phase 2
23 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
24 Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR Unknown status NCT01755221 Not Applicable
25 Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children Unknown status NCT02056379 Not Applicable Budesonide;Dexamethasone
26 Intestinal Microbiota Composition After Antibiotic Treatment in Early Life Unknown status NCT02536560
27 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220 Not Applicable
28 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole
29 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Not Applicable Rabeprazole 20mg twice daily
30 Non Interventional Study (NIS) Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
31 Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists Completed NCT02048449
32 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
33 Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments Completed NCT01767064 Not Applicable
34 A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children Completed NCT00626808 No Intervention
35 Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children. Completed NCT01861548
36 Repeated Versus Varied Simulation Scenarios to Teach Medical Students the Management of a Pediatric Asthma Exacerbation Completed NCT02754310 Not Applicable
37 The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold Enrolling by invitation NCT03309995 Not Applicable
38 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849 Not Applicable

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

41
Lymph Node, Thyroid, Lung, Endothelial, Bone, T Cells, Tongue

Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 3636)
# Title Authors Year
1
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities. ( 29673563 )
2018
2
Laryngeal Chondrosarcoma: A rare cause of critical upper airway obstruction. ( 29869857 )
2018
3
Sweet's syndrome with laryngoparalysis due to laryngitis. ( 29696681 )
2018
4
Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )
2018
5
Spread of dystonia in patients with idiopathic adult-onset laryngeal dystonia. ( 29935029 )
2018
6
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
7
Severe angioedema of laryngeal inlet in a woman receiving telmisartan therapy undergoing breast conservation surgery. ( 29910501 )
2018
8
Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery. ( 29682274 )
2018
9
Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )
2018
10
Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor. ( 29423509 )
2018
11
Correlation between bulbar functionality and laryngeal penetration and/or laryngotracheal aspiration on motor neuron disease. ( 29513871 )
2018
12
Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )
2018
13
Laryngeal cleft type IV: One pathology, two different presentations. ( 29728171 )
2018
14
Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany. ( 29725537 )
2018
15
Eosinophilic granulomatosis with polyangiitis and laryngeal involvement: review of the literature and a cross-sectional prospective experience. ( 29888684 )
2018
16
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
17
Simple laryngeal suspension procedure by suturing the digastric muscle to the periosteum of the mandible in neck dissection for tongue cancer. ( 29395281 )
2018
18
Laryngeal ultrasound for the diagnosis of laryngomalacia in infants. ( 29405660 )
2018
19
Air- Q intubating laryngeal airway guided intubation in Morquio syndrome. ( 29962532 )
2018
20
Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population-based study. ( 29412495 )
2018
21
Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. ( 29443735 )
2018
22
Tumor suppression effect of targeting periostin with siRNA in a nude mouse model of human laryngeal squamous cell carcinoma. ( 29978598 )
2018
23
Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. ( 29869750 )
2018
24
Use of a national identification database to determine the lifetime prognosis in cattle with necrotic laryngitis and the predictive value of venous pCO<sub>2</sub>. ( 29968934 )
2018
25
Development and validation of a quality of life instrument for patients with laryngeal cleft. ( 29605344 )
2018
26
Classifying and Diagnosing Laryngeal Dystonia-Are We Artists or Are We Scientists? ( 29931264 )
2018
27
Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. ( 29598944 )
2018
28
Fibroblast growth factor receptor 1 amplification in laryngeal squamous cell carcinoma. ( 29351293 )
2018
29
Laryngeal papillomatosis in Senegal: A ten-year experience. ( 29396224 )
2018
30
Primary Laryngeal Tuberculosis: Our Experiences at a Tertiary Care Teaching Hospital in Eastern India. ( 29773323 )
2018
31
Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. ( 29017739 )
2018
32
Pulmonary melioidosis with laryngeal involvement: an unusual site of infection. ( 29374089 )
2018
33
SWALLOWING IN PATIENTS WITH LARYNGITIS. ( 29561977 )
2018
34
Laryngeal tuberculosis: a rare cause of critical airway obstruction. ( 29348284 )
2018
35
Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression. ( 29930164 )
2018
36
Laryngeal Tuberculosis Mimicking Laryngeal Carcinoma on <sup>18</sup>F-FDG PET/CT Imaging. ( 29889030 )
2018
37
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )
2018
38
Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )
2018
39
CCL20/CCR6 promotes cell proliferation and metastasis in laryngeal cancer by activating p38 pathway. ( 27916417 )
2017
40
A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )
2017
41
[Pediatric laryngeal clefts: an experience in the diagnosis and management of 13 cases]. ( 28910893 )
2017
42
The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone. ( 28475003 )
2017
43
Factors Associated With Infectious Laryngitis: A Retrospective Review of 15 Cases. ( 28397557 )
2017
44
Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6. ( 28466560 )
2017
45
Downregulation of miRNA-26b inhibits cancer proliferation of laryngeal carcinoma through autophagy by targeting ULK2 and inactivation of the PTEN/AKT pathway. ( 28713931 )
2017
46
Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma. ( 28225775 )
2017
47
There is no correlation between signs of reflux laryngitis and reflux oesophagitis in patients with gastro-oesophageal reflux disease symptoms. ( 29165435 )
2017
48
WRAP53I^, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer. ( 28849066 )
2017
49
Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. ( 28910519 )
2017
50
Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. ( 28102032 )
2017

Variations for Laryngitis

Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 ATP12A ATP4A IL1B IL6 TGFB1 TNF
2
Show member pathways
13.36 FGF2 IL1B IL6 TGFB1 TNF
3
Show member pathways
13.26 FGF2 IL1B IL6 TGFB1 TNF
4
Show member pathways
13.21 FGF2 IL1B IL6 TGFB1 TNF
5
Show member pathways
13.14 FGF2 IL1B IL6 TGFB1 TNF
6
Show member pathways
12.88 IL1B IL6 TGFB1 TNF
7
Show member pathways
12.76 IL1B IL6 TGFB1 TNF
8 12.63 FGF2 IL1B TGFB1 TNF
9
Show member pathways
12.49 FGF2 IL1B IL6 TGFB1 TNF
10
Show member pathways
12.47 FGF2 IL1B IL6 TNF
11
Show member pathways
12.45 FGF2 IL6 TGFB1 TNF
12
Show member pathways
12.33 IL1B IL6 TGFB1 TNF
13 12.31 IL6 TGFB1 TNF
14
Show member pathways
12.31 IL1B IL6 TGFB1 TNF
15
Show member pathways
12.24 IL1B IL6 TNF
16
Show member pathways
12.23 IL1B IL6 TNF
17 12.2 FGF2 TGFB1 TNF
18
Show member pathways
12.17 IL1B IL6 TNF
19
Show member pathways
12.16 IL1B TGFB1 TNF
20
Show member pathways
12.13 IL1B IL6 TNF
21
Show member pathways
12.13 IL1B IL6 TGFB1 TNF
22
Show member pathways
12.12 IL1B IL6 TNF
23
Show member pathways
12.12 IL6 TGFB1 TNF
24 12.1 IL1B IL6 TGFB1 TNF
25
Show member pathways
12.09 IL1B IL6 TNF
26 12.08 IL6 TGFB1 TNF
27 12.08 IL1B IL6 TNF
28
Show member pathways
12.06 FGF2 TGFB1 TNF
29 11.97 FGF2 IL6 TGFB1
30 11.97 IL6 TGFB1 TNF
31
Show member pathways
11.96 FGF2 IL1B IL6 TGFB1
32 11.95 IL1B TGFB1 TNF
33 11.87 IL1B IL6 TNF
34 11.86 IL1B IL6 TGFB1
35 11.84 IL1B IL6 TGFB1 TNF
36 11.81 IL1B IL6 TNF
37 11.73 IL1B IL6 TGFB1 TNF
38 11.69 IL1B IL6 TGFB1 TNF
39 11.68 IL1B IL6 TNF
40 11.62 IL1B IL6 TGFB1 TNF
41
Show member pathways
11.59 IL1B IL6 TNF
42 11.51 IL1B IL6 TNF
43 11.49 IL1B IL6 TGFB1 TNF
44 11.46 IL1B IL6 TNF
45 11.44 IL1B TGFB1 TNF
46 11.43 FGF2 IL6 TGFB1
47 11.41 FGF2 IL1B IL6 TGFB1 TNF
48 11.4 IL1B IL6 TNF
49 11.27 IL1B IL6
50 11.26 IL1B IL6 TNF

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ATP4A FGF2 IL1B IL6 TGFB1 TNF

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 FGF2 IL1B IL6 TGFB1
2 immune response GO:0006955 9.95 HRH2 IL1B IL6 TNF
3 inflammatory response GO:0006954 9.91 IL1B IL6 TGFB1 TNF
4 positive regulation of gene expression GO:0010628 9.9 IL1B IL6 TGFB1 TNF
5 positive regulation of transcription, DNA-templated GO:0045893 9.89 FGF2 IL1B IL6 TGFB1 TNF
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 FGF2 TGFB1 TNF
7 leukocyte migration GO:0050900 9.87 IL1B TGFB1 TNF
8 positive regulation of protein phosphorylation GO:0001934 9.85 IL1B TGFB1 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.84 FGF2 TGFB1 TNF
10 MAPK cascade GO:0000165 9.84 FGF2 IL1B TGFB1 TNF
11 activation of MAPK activity GO:0000187 9.79 FGF2 IL1B TNF
12 positive regulation of DNA binding transcription factor activity GO:0051091 9.79 IL1B IL6 TNF
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.74 IL6 TGFB1 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IL1B TNF
15 cellular response to organic cyclic compound GO:0071407 9.73 IL1B TGFB1 TNF
16 digestive tract development GO:0048565 9.72 HRH2 TGFB1
17 negative regulation of blood vessel endothelial cell migration GO:0043537 9.72 FGF2 TGFB1
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.72 FGF2 TNF
19 potassium ion import GO:0010107 9.72 ATP12A ATP4A
20 regulation of angiogenesis GO:0045765 9.72 FGF2 IL6
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 IL1B TNF
22 positive regulation of phagocytosis GO:0050766 9.71 IL1B TNF
23 negative regulation of mitotic cell cycle GO:0045930 9.71 TGFB1 TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
25 osteoclast differentiation GO:0030316 9.7 TGFB1 TNF
26 ATP hydrolysis coupled proton transport GO:0015991 9.7 ATP12A ATP4A
27 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.7 FGF2 TGFB1
28 protein import into nucleus, translocation GO:0000060 9.7 TGFB1 TNF
29 positive regulation of MAP kinase activity GO:0043406 9.7 FGF2 TGFB1 TNF
30 positive regulation of interleukin-8 production GO:0032757 9.69 IL1B TNF
31 positive regulation of vascular endothelial growth factor production GO:0010575 9.69 IL1B TGFB1
32 positive regulation of protein complex assembly GO:0031334 9.68 TGFB1 TNF
33 negative regulation of myoblast differentiation GO:0045662 9.68 TGFB1 TNF
34 positive regulation of chemokine production GO:0032722 9.68 IL6 TNF
35 positive regulation of histone acetylation GO:0035066 9.68 IL1B TGFB1
36 cellular sodium ion homeostasis GO:0006883 9.67 ATP12A ATP4A
37 negative regulation of lipid catabolic process GO:0050995 9.66 IL1B TNF
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
39 hyaluronan catabolic process GO:0030214 9.65 FGF2 TGFB1
40 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
41 cellular potassium ion homeostasis GO:0030007 9.64 ATP12A ATP4A
42 sodium ion export across plasma membrane GO:0036376 9.64 ATP12A ATP4A
43 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.63 ATP12A ATP4A
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
45 negative regulation of lipid storage GO:0010888 9.59 IL6 TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
47 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
48 positive regulation of cell division GO:0051781 9.58 FGF2 IL1B TGFB1
49 positive regulation of fever generation GO:0031622 9.55 IL1B TNF
50 regulation of signaling receptor activity GO:0010469 9.55 FGF2 IL1B IL6 TGFB1 TNF

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 FGF2 IL6 TGFB1
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 cytokine activity GO:0005125 9.02 FGF2 IL1B IL6 TGFB1 TNF
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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