Laryngitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LRY019 MIFTS: 51	Laryngitis Categories: Infectious diseases, Oral diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis ¹² ⁴³ ¹⁵ ⁷¹

Acute Laryngitis ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3437

MeSH ⁴³ D007827

NCIt ⁴⁹ C26811

SNOMED-CT ⁶⁷ 45913009

UMLS ⁷¹ C0001327 C0023067

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Summaries for Laryngitis

Disease Ontology : ¹² A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and chronic laryngitis, and has symptoms including throat irritation An important gene associated with Laryngitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Fluticasone and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia : ⁷⁴ Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

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Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis	Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1654)

#	Related Disease	Score	Top Affiliating Genes
1	acute laryngitis	34.4	ATP4A ATP12A
2	chronic laryngitis	33.9	LVRN HRH2 ATP4A ATP12A
3	gastroesophageal reflux	31.4	TNF TGFB1 IL6 IL1B HRH2 GABBR1
4	pulmonary tuberculosis	31.1	TNF IL6 CRP
5	sudden infant death syndrome	30.8	TNF IL6 IL1B IL1A
6	esophagitis	30.6	TNF TGFB1 IL6 IL1B HRH2
7	amyloidosis	30.5	TNF IL6 CRP CD40LG
8	ankylosis	30.5	TNF TGFB1 CRP
9	neuroma	30.5	TGFB1 IL6 FGF2
10	neuritis	30.5	TNF IL6 IL1B
11	pulmonary edema	30.4	TNF IL1B CRP
12	sleep apnea	30.4	TNF IL6 IL1B CRP
13	candidiasis	30.4	TNF IL6 IL1B CD40LG
14	aspergillosis	30.3	TNF IL6 IL1B
15	respiratory failure	30.3	TNF IL6 IL1B CRP
16	cerebral palsy	30.3	TNF IL6 IL1B
17	spondylitis	30.3	TNF IL6 CRP
18	gout	30.3	TNF IL6 IL1B
19	fibrosarcoma	30.2	TNF TGFB1 IL1A FGF2
20	varicose veins	30.2	TNF IL6 FGF2
21	myositis	30.2	TNF IL6 IL1B IL1A
22	extrapulmonary tuberculosis	30.2	TNF IL1B CRP
23	endocarditis	30.2	TNF IL6 CRP
24	angioedema	30.1	IL6 CRP CD40LG
25	leptin deficiency or dysfunction	30.1	TNF IL6 CRP
26	tonsillitis	30.1	TNF IL6 IL1B IL1A
27	post-transplant lymphoproliferative disease	30.1	TNF IL6 IL1A
28	paracoccidioidomycosis	30.1	TNF IL6 CD40LG
29	herpes zoster	30.1	TNF CRP CD40LG
30	measles	30.1	TNF IL6 IL1B CD40LG
31	cytomegalovirus infection	30.1	TNF IL6 IL1B
32	gastrointestinal ulceration, recurrent, with dysfunctional platelets	30.0	HRH2 FGF2
33	visceral leishmaniasis	30.0	TNF IL1B CRP
34	osteomyelitis	30.0	TNF IL6 IL1B IL1A
35	lymphadenitis	30.0	TNF IL1B CRP
36	aspiration pneumonia	30.0	IL6 CRP CD40LG ATP4A ATP12A
37	sarcoidosis 1	30.0	TNF IL1B IL1A CRP CD40LG
38	chickenpox	30.0	TNF IL6 CRP CD40LG
39	pertussis	30.0	TNF IL6 IL1B IL1A
40	influenza	30.0	TNF IL6 IL1B IL1A
41	mononeuropathy	30.0	TNF CRP CD40LG
42	mediastinitis	30.0	CRP ATP4A ATP12A
43	mumps	30.0	TNF IL6 CD40LG
44	bone disease	29.9	TNF IL6 IL1B IL1A
45	leishmaniasis	29.9	TNF TGFB1 IL6 IL1B IL1A CRP
46	vasculitis	29.9	TNF IL6 CRP CD40LG
47	gingivitis	29.9	TNF IL6 IL1B IL1A
48	peptic esophagitis	29.9	IL6 IL1B HRH2 ATP4A ATP12A
49	esophageal cancer	29.9	TNF TGFB1 IL6 IL1B FGF2 CRP
50	miliary tuberculosis	29.9	TNF CRP CD40LG

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Bronchitis
Deficiency Anemia	Esophagitis
Heart Disease	Hypertension, Essential
Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:

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Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

throat irritation

MGI Mouse Phenotypes related to Laryngitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.73	ATP12A ATP4A CD40LG CRP FGF2 GABBR1
2	neoplasm	MP:0002006	9.17	ATP4A FGF2 IL1A IL1B IL6 TGFB1

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Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Meloxicam

Approved, Vet_approved

Phase 4

71125-38-7

5281106 54677470

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Dexlansoprazole

Approved, Investigational

Phase 4

138530-94-6, 103577-45-3

9578005

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Neurotransmitter Agents

Phase 4

Adrenergic Agents

Phase 4

Sympathomimetics

Phase 4

Adrenergic beta-Agonists

Phase 4

Salmeterol xinafoate

Phase 4

94749-08-3

56801

Anti-Asthmatic Agents

Phase 4

Hormone Antagonists

Phase 4

Fluticasone-Salmeterol Drug Combination

Phase 4

Respiratory System Agents

Phase 4

Autonomic Agents

Phase 4

Adrenergic Agonists

Phase 4

Bronchodilator Agents

Phase 4

Anti-Allergic Agents

Phase 4

glucocorticoids

Phase 4

Hormones

Phase 4

Anti-Inflammatory Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Cyclooxygenase 2 Inhibitors

Phase 4

Antirheumatic Agents

Phase 4

Rabeprazole

Approved, Investigational

Phase 2, Phase 3

117976-89-3

5029

Perphenazine

Approved

Phase 2, Phase 3

58-39-9

4748

Amitriptyline

Approved

Phase 2, Phase 3

50-48-6

2160

Tranquilizing Agents

Phase 2, Phase 3

Antipsychotic Agents

Phase 2, Phase 3

Analgesics, Non-Narcotic

Phase 2, Phase 3

Psychotropic Drugs

Phase 2, Phase 3

Amitriptyline, perphenazine drug combination

Phase 2, Phase 3

Antidepressive Agents

Phase 2, Phase 3

Central Nervous System Depressants

Phase 2, Phase 3

Analgesics

Phase 2, Phase 3

Antidepressive Agents, Tricyclic

Phase 2, Phase 3

Peppermint

Approved

Phase 1, Phase 2

Oregano

Approved

Phase 1, Phase 2

Rosemary

Experimental

Phase 1, Phase 2

Eucalyptus

Phase 1, Phase 2

Nitric Oxide

Approved

Phase 1

10102-43-9

145068

8-epi-prostaglandin F2alpha

Phase 1

Vasodilator Agents

Phase 1

Free Radical Scavengers

Phase 1

Antioxidants

Phase 1

Protective Agents

Phase 1

Dexamethasone acetate

Approved, Investigational, Vet_approved

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

50-02-2

5743

Interventional clinical trials:

(show all 35)

#	Name	Status	NCT ID	Phase	Drugs
1	A Pilot Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID as Assessed by the Development of Laryngitis and Oropharyngeal Candidiasis in Adults With Mild Persistent Asthma	Unknown status	NCT00235053	Phase 4	fluticasone/salmeterol DISKUS 250/50
2	A Multicenter, Double -Blind, Placebo-controlled Study to Evaluate the Effects of Esomeprazole 40mg Bid on the Signs and Symptoms of Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux	Completed	NCT00628667	Phase 4	Esomeprazole;Placebo
3	Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis	Completed	NCT02229747	Phase 4	Meloxicam;Diclofenac;Nimesulide
4	Laryngopharyngeal Reflux Health Related Quality of Life (LPR-HRQL) Questionnaire Development and Psychometric Testing in Patients Receiving Omeprazole 20 mg Bid as Treatment for Laryngopharyngeal Reflux.	Completed	NCT00641264	Phase 4	Omeprazole
5	Do Laryngeal Biopsy Findings Predict Treatment Response in Suspected Laryngopharyngeal Reflux	Completed	NCT00444145	Phase 4	Prevacid
6	Role of Esophageal and Laryngeal Biopsies in Suspected Laryngopharyngeal Reflux	Completed	NCT00373997	Phase 4
7	A Randomized, Placebo-Controlled Assessment of Lansoprazole 30 mg Bid in the Treatment of Gastroesophageal Reflux Associated With Laryngitis	Terminated	NCT00369265	Phase 4	Lansoprazole
8	A New Nasopharyngeal pH Probe for Diagnosis of Laryngopharyngeal Reflux	Withdrawn	NCT01308502	Phase 4
9	CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study	Completed	NCT01948856	Phase 3	J022X ST;Placebo
10	A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Alginos Oral Suspension (Sodium Alginate 50 mg/ml) for the Treatment of Patients With Laryngopharyngeal Reflux (LPR)	Completed	NCT01450748	Phase 3	Sodium alginate;Placebo
11	Identification of Molecular Markers of Inflammatory Mediators in Posterior Laryngitis Due to Laryngopharyngeal Reflux and Evolution With PPI Treatment	Completed	NCT00204698	Phase 2, Phase 3	Aciphex
12	Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline	Enrolling by invitation	NCT02552225	Phase 2, Phase 3	Amitriptyline
13	Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline	Terminated	NCT02434523	Phase 2, Phase 3	Amitriptyline
14	Effect of Aggressive Acid Suppression With Esomeprazole on Vocal Cord Granulomas: Randomized Placebo-Controlled Trial	Withdrawn	NCT00567658	Phase 3	Esomeprazole
15	Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Some Aromatic Medical Plants.	Completed	NCT00611390	Phase 1, Phase 2
16	Post-nasal Drainage as an Extraesophageal Manifestation of Reflux	Completed	NCT00199953	Phase 2	Rabeprazole 20 mg twice a day for 90-day period treatment
17	Comparison of GERD and the Effects of Anti-Reflux Therapy on Pulmonary Function Between Able-Bodied and SCI Individuals	Unknown status	NCT02584751	Phase 1	Omeprazole
18	A Prospective Evaluation of the Utility, Optimal Cutoff and Positive Predictive Value of a Pharyngeal pH Probe for Predicting Proton Pump Inhibitor Response in Treatment Naive Laryngopharyngeal Reflux	Unknown status	NCT01755221
19	Comparison Between Inhaled Budesonide and Intravenous Dexamethasone Treatments for Postextubation Stridor in Children	Unknown status	NCT02056379		Budesonide;Dexamethasone
20	Non Interventional Study Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis	Completed	NCT02160912
21	Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients	Completed	NCT00517114		Rabeprazole 20mg twice daily
22	Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis: Final Results	Completed	NCT01389401		omeprazole
23	Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis	Completed	NCT01806220
24	Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)	Completed	NCT01406275		Amoxicillin and clavulanate
25	Inter-rater Reliability of the Reflux Finding Score Based on Endoscopic Laryngeal Findings in the Diagnosis of Laryngopharyngeal Reflux Disease	Completed	NCT02048449
26	ADHERE Study: Application of Dx-pH Catheter for Extra-esophageal Reflux Evaluation	Completed	NCT00388453
27	The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold: a Randomized Trial	Completed	NCT03309995
28	ELVIS (Esophagitis-Laparoscopy Versus Inhibitors of Secretion) A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication (LNF) Versus Omeprazole for Treatment of Patients With Chronic Gastro-Esophageal Reflux Disease (GERD)	Completed	NCT00182260		Proton Pump Inhibitors
29	DUAL BRAVO PH MONITORING: A Feasibility Trial	Completed	NCT00378898
30	Polish Mother and Child Cohort Study (REPRO_PL).Follow up of the Children.	Completed	NCT01861548
31	The Diagnostics of Extraesophageal Reflux With the Restech System in Patients With Chronic Rhinosinusitis	Completed	NCT01819454
32	Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit	Recruiting	NCT04165356
33	Impact of Chronic Rhinosinusitis on the Laryngeal Mucosa and Voice Quality in Children Aged From 6- to 18- Years Old	Not yet recruiting	NCT03696693
34	Role of Ultrasound in Diagnosis of Laryngeal Lesions	Not yet recruiting	NCT03450694
35	Does Gastric Reflux Induce Sinonasal Symptoms?	Not yet recruiting	NCT04105894		medical treatment of GERD t

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Guaifenesin

Cochrane evidence based reviews: laryngitis

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Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

⁴⁰

Thyroid, Heart, Bone, Lung, Skin, T Cells, Brain

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Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 1712)

#	Title	Authors	PMID	Year
1	Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. ⁶¹	Malagon-Rojas JN...Szajewska H	32024037	2020
2	Scrophularia koraiensis Nakai Attenuates Allergic Airway Inflammation via Suppression of NF-κB and Enhancement of Nrf2/HO-1 Signaling. ⁶¹	Jung TY...Kim JS	31991647	2020
3	Characteristics and Voice Outcomes of Ulcerative Laryngitis. ⁶¹	Young VN...Rosen CA	30170913	2020
4	Effects of Particle Size of Inhaled Corticosteroid on the Voice. ⁶¹	Vance D...Sataloff RT	31902681	2020
5	Determinants of successful tracheostomy decannulation in children: a multicentric cohort study. ⁶¹	Schweiger C...Gomes Avelino M	31910909	2020
6	Aspects concerning patient adherence to anti-TNFα therapy in psoriasis: A decade of clinical experience. ⁶¹	Mocanu M...Taranu T	31798720	2019
7	Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study. ⁶¹	Arnell H...Pontes-Arruda A	31567786	2019
8	A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis. ⁶¹	Wongkamhla T...Jitmuang A	31805893	2019
9	Vocal Characteristics of School-Aged Children With and Without Attention Deficit Hyperactivity Disorder. ⁶¹	Moodley DT...van der Linde J	30115579	2019
10	Leukoplakia or LPR: The Misdiagnosis of Laryngeal Tuberculosis. ⁶¹	Lou ZC...Li X	31779475	2019
11	Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis. ⁶¹	Cates DJ...Smith LJ	31120608	2019
12	Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. ⁶¹	Lehman B...Benninger MS	30912581	2019
13	Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom Index. ⁶¹	Eckley CA...Tangerina R	31586513	2019
14	Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review. ⁶¹	Sobhani Z...Sahebkar A	31670624	2019
15	Herpes Zoster Laryngitis with Disseminated Cutaneous Lesions. ⁶¹	Kuroda H...Hase R	31243199	2019
16	Vocal Characteristics of Patients With Morbid Obesity. ⁶¹	Bosso JR...Naresse LE	31648859	2019
17	Isolated Laryngeal Leishmaniasis: A Diagnostic Dilemma. ⁶¹	Aggarwal K...Kumar R	31742085	2019
18	A Comprehensive Analysis of Benign Vocal Fold Lesions Causing Hoarseness of Voice and Our Experience with Cold Knife Endolaryngeal Surgery in a Tertiary Healthcare Centre. ⁶¹	Upadhyay A...Mundra RK	31742013	2019
19	The Role of Allergy in Phonation. ⁶¹	Spantideas N...Assimakopoulos D	30145066	2019
20	The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. ⁶¹	Frank NM...TEDDY Study Group	31533753	2019
21	Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria. ⁶¹	Stefani T...Camacho-Corona MDR	31546651	2019
22	Updates in the field of non-esophageal gastroesophageal reflux disorder. ⁶¹	Ghisa M...Savarino E	31322443	2019
23	Association of voice and mental health diagnoses with differences in voice-related care utilization. ⁶¹	Jordan VA...Misono S	31508825	2019
24	Characteristics of swallowing disorders in patients with dysphonia. ⁶¹	Krasnodebska P...Miaskiewicz B	32022701	2019
25	Reaction to Clindamycin Causing Laryngitis and Esophagitis. ⁶¹	Rutt AL...Wang CE	31569974	2019
26	A review for the neuroprotective effects of andrographolide in the central nervous system. ⁶¹	Lu J...Huang C	31181444	2019
27	Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology. ⁶¹	Hamdan AL...El Hage A	29884508	2019
28	Acute supraglottic laryngitis complicated by vocal fold immobility: prognosis and management. ⁶¹	Ringel B...Oestreicher-Kedem Y	31214824	2019
29	Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults. ⁶¹	Lee K...Kim TH	31415057	2019
30	Identification and Management of Chronic Laryngitis. ⁶¹	Zhukhovitskaya A...Verma SP	31101358	2019
31	Can the Reflux Finding Score and Reflux Symptom Index Be Used to Evaluate the Severity of Esophagitis in Children? ⁶¹	Ugras MK...Ozkan F	31447186	2019
32	A Novel ALK-THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. ⁶¹	Elktaibi A...Costes Martineau V	31368077	2019
33	Characteristics of a Treatment-seeking Population in a Private Practice Community Voice Clinic: An Epidemiologic Study. ⁶¹	Watts CR...Knickerbocker K	29310885	2019
34	Allergic laryngitis: chronic laryngitis and allergic sensitization. ⁶¹	Campagnolo A...Benninger MS	30898484	2019
35	Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity. ⁶¹	Worrall DM...Woo P	30678486	2019
36	Airflow Patterns of Running Speech in Patients With Voice Disorders. ⁶¹	Gilman M...Hapner ER	30057271	2019
37	A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx. ⁶¹	Kim H...Byeon HK	31104410	2019
38	A comparative and correlative study of the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) for voice-related quality of life among teachers with and without voice disorders. ⁶¹	Yu L...Hu J	30817565	2019
39	[Influence of TNF-α on the immunomodulatory property of laryngeal mucosa mesenchymal stromal cells']. ⁶¹	Liu H...Jin Y	30909341	2019
40	Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan. ⁶¹	Warsi I...Khurshid Z	30928919	2019
41	Intralesional Cidofovir for Treatment of Acyclovir-Resistant Laryngeal Herpes Manifesting as Supraglottic Mass. ⁶¹	Yang CQ...Dhillon VK	30556399	2019
42	[Antibiotic Prescribing in Ambulatory Care of Pediatric Patients with Respiratory Infections]. ⁶¹	Andrade JV...Camurca T	30896390	2019
43	Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population. ⁶¹	Okamoto Y...Masuyama K	30281866	2019
44	Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review. ⁶¹	Casale M...Rinaldi V	31534961	2019
45	Acute subglottic laryngitis. Etiology, epidemiology, pathogenesis and clinical picture. ⁶¹	Mazurek H...Zielnik-Jurkiewicz B	31680234	2019
46	[Acute and chronic laryngitis in the subjects engaged in the voice and speech professions]. ⁶¹	Stepanova YE...Mal'tseva GS	30938347	2019
47	Lung function parameters in patients with gastroesophageal reflux without respiratory symptoms: a case-control study. ⁶¹	Nazemiyeh M...Sharifi A	31749916	2019
48	[Features of microsurgery of the vestibular larynx using CO and a diode laser]. ⁶¹	Vavin VV...Dobretsov KG	31198217	2019
49	Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study. ⁶¹	Lou Z...Jiang JJ	30535974	2019
50	[Upper respiratory tract infections (sinusitis, otitis, laryngitis ect.)]. ⁶¹	Zengel P	30671826	2019

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Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNF	Tumor Necrosis Factor	Protein Coding	11.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	IL6	Interleukin 6	Protein Coding	11.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	HRH2	Histamine Receptor H2	Protein Coding	11.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	IL1B	Interleukin 1 Beta	Protein Coding	10.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL1A	Interleukin 1 Alpha	Protein Coding	9.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	8.3	DISEASES inferred ¹⁵
7	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	8.3	DISEASES inferred ¹⁵
8	MIR500A	MicroRNA 500a	RNA Gene	7.18	DISEASES inferred ¹⁵ ¹⁵
9	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	6.73	GeneCards inferred via : Publications (show sections)
10	FGF2	Fibroblast Growth Factor 2	Protein Coding	6.53	GeneCards inferred via : Publications (show sections)
11	LVRN	Laeverin	Protein Coding	5.36	DISEASES inferred ¹⁵
12	GNRH2	Gonadotropin Releasing Hormone 2	Protein Coding	5.32	DISEASES inferred ¹⁵
13	CRP	C-Reactive Protein	Protein Coding	5.31	DISEASES inferred ¹⁵
14	TTLL1	Tubulin Tyrosine Ligase Like 1	Protein Coding	5.16	DISEASES inferred ¹⁵
15	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	5.16	DISEASES inferred ¹⁵
16	CD40LG	CD40 Ligand	Protein Coding	5.07	DISEASES inferred ¹⁵

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Variations for Laryngitis

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Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

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Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.78	TNF TGFB1 IL6 IL1B IL1A GNRH2
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.39	TNF TGFB1 IL6 IL1B IL1A GNRH2
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.34	TNF TGFB1 IL6 IL1B IL1A FGF2
4	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.27	TNF TGFB1 IL6 IL1B IL1A GNRH2
5	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.84	TNF TGFB1 IL6 IL1B IL1A CD40LG
6	MAPK signaling pathway ³⁶ ¹	12.76	TNF TGFB1 IL1B IL1A FGF2
7	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.6	TNF TGFB1 IL6 IL1B IL1A
8	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.57	TNF TGFB1 IL6 IL1B IL1A CD40LG
9	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.33	TNF IL6 IL1B CRP
10	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.31	TNF IL6 IL1B IL1A FGF2
11	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.24	TNF TGFB1 IL1B IL1A CD40LG
12	IL-1 Family Signaling Pathways ⁶⁴ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.23	TNF IL6 IL1B IL1A
13	Tuberculosis ³⁶	12.21	TNF TGFB1 IL6 IL1B IL1A
14	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.19	TNF TGFB1 IL6 IL1B IL1A GNRH2
15	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.18	TNF IL6 IL1B IL1A
16	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.18	TNF TGFB1 IL6 IL1B IL1A GNRH2
17	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁴	12.07	TNF TGFB1 IL6 IL1B
18	Osteoclast differentiation ³⁶	12.06	TNF TGFB1 IL1B IL1A
19	Spinal Cord Injury ¹	11.99	TNF TGFB1 IL6 IL1B IL1A
20	Senescence and Autophagy in Cancer ¹	11.96	TGFB1 IL6 IL1B IL1A
21	Amoebiasis ³⁶	11.94	TNF TGFB1 IL6 IL1B
22	Hematopoietic cell lineage ³⁶	11.91	TNF IL6 IL1B IL1A
23	NF-kappa B signaling pathway ³⁶	11.89	TNF IL1B CD40LG
24	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.88	TNF TGFB1 IL6 IL1B IL1A
25	Rheumatoid arthritis ³⁶	11.82	TNF TGFB1 IL6 IL1B IL1A
26	Salmonella infection (KEGG) ³⁶	11.78	IL6 IL1B IL1A
27	Pertussis ³⁶	11.77	TNF IL6 IL1B IL1A
28	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.75	TNF TGFB1 IL6 IL1B
29	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁴	11.73	TNF TGFB1 IL6 IL1B
30	G-protein signaling_RhoA regulation pathway ²²	11.7	TGFB1 IL6 GNRH2 FGF2
31	Interleukin-4 and 13 signaling ⁶⁵	11.69	TNF TGFB1 IL6 IL1B IL1A FGF2
32	Legionellosis ³⁶	11.62	TNF IL6 IL1B
33	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.57	TNF IL6 IL1B IL1A CD40LG
34	Hematopoietic Stem Cell Differentiation ¹	11.54	IL6 IL1B IL1A
35	Differentiation Pathway ¹	11.53	TGFB1 IL6 FGF2
36	Aryl Hydrocarbon Receptor Pathway ¹	11.53	TNF TGFB1 IL1B
37	Interleukin-10 signaling ⁶⁵	11.53	TNF IL6 IL1B IL1A
38	Lung fibrosis ¹	11.52	TNF TGFB1 IL6 IL1B FGF2
39	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.48	TNF IL6 IL1B IL1A
40	African trypanosomiasis ³⁶	11.41	TNF IL6 IL1B
41	Prion diseases ³⁶	11.38	IL6 IL1B IL1A
42	Malaria ³⁶	11.35	TNF TGFB1 IL6 IL1B CD40LG
43	IL-10 Pathway ⁶³	11.34	TNF IL6 IL1B IL1A
44	Development and heterogeneity of the ILC family ¹	11.33	TNF IL6 IL1B
45	Antifolate resistance ³⁶	11.31	TNF IL6 IL1B
46	Overview of nanoparticle effects ¹	11.06	TNF IL6 CRP
47	G-protein signaling_Rap2B regulation pathway ²²	10.91	TNF TGFB1 IL6 IL1B IL1A GNRH2
48	RXR and RAR heterodimerization with other nuclear receptor ¹	10.85	TNF TGFB1
49	Interleukin-1 processing ⁶⁵	10.54	IL1B IL1A
50	Cytokines and Inflammatory Response ¹	10.48	TNF TGFB1 IL6 IL1B IL1A

Sources

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	TTLL1 TNF TGFB1 IL6 IL1B IL1A
2	extracellular space	GO:0005615	9.36	TNF TGFB1 MIR500A IL6 IL1B IL1A

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.25	TGFB1 IL6 IL1B HRH2 GNRH2 GABBR1
2	positive regulation of transcription, DNA-templated	GO:0045893	10.07	TNF TGFB1 IL6 IL1B FGF2
3	immune response	GO:0006955	9.97	TNF IL6 IL1B IL1A HRH2 CD40LG
4	MAPK cascade	GO:0000165	9.96	TNF TGFB1 IL1B FGF2
5	positive regulation of gene expression	GO:0010628	9.95	TNF TGFB1 IL6 IL1B IL1A CRP
6	cellular response to lipopolysaccharide	GO:0071222	9.89	TNF IL6 IL1B IL1A
7	defense response to Gram-positive bacterium	GO:0050830	9.86	TNF IL6 CRP
8	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.84	TNF TGFB1 IL6
9	positive regulation of JNK cascade	GO:0046330	9.83	TNF IL1B IL1A
10	cellular response to organic cyclic compound	GO:0071407	9.82	TNF TGFB1 IL1B
11	positive regulation of MAP kinase activity	GO:0043406	9.81	TNF TGFB1 FGF2
12	positive regulation of T cell proliferation	GO:0042102	9.8	IL6 IL1B CD40LG
13	negative regulation of fat cell differentiation	GO:0045599	9.77	TNF TGFB1 IL6
14	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.77	TNF TGFB1 IL6 IL1B CD40LG
15	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.76	TGFB1 IL6 IL1B
16	protein kinase B signaling	GO:0043491	9.74	TNF TGFB1 IL1B
17	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.73	TNF IL1B IL1A
18	positive regulation of interleukin-6 production	GO:0032755	9.73	TNF IL6 IL1B IL1A
19	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.7	TNF TGFB1 IL1B
20	negative regulation of neurogenesis	GO:0050768	9.69	TNF IL6 IL1B
21	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.68	IL1B IL1A
22	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.68	ATP4A ATP12A
23	sodium ion export across plasma membrane	GO:0036376	9.67	ATP4A ATP12A
24	cellular potassium ion homeostasis	GO:0030007	9.67	ATP4A ATP12A
25	positive regulation of chemokine biosynthetic process	GO:0045080	9.67	TNF IL1B
26	regulation of establishment of endothelial barrier	GO:1903140	9.64	TNF IL1B
27	ectopic germ cell programmed cell death	GO:0035234	9.64	IL1B IL1A
28	positive regulation of glial cell proliferation	GO:0060252	9.63	TNF IL6 IL1B
29	cytokine-mediated signaling pathway	GO:0019221	9.63	TNF TGFB1 IL6 IL1B IL1A FGF2
30	positive regulation of mononuclear cell migration	GO:0071677	9.62	TNF TGFB1
31	regulation of immunoglobulin secretion	GO:0051023	9.62	TNF CD40LG
32	positive regulation of fever generation	GO:0031622	9.61	TNF IL1B
33	connective tissue replacement involved in inflammatory response wound healing	GO:0002248	9.61	TGFB1 IL1A
34	sequestering of triglyceride	GO:0030730	9.58	TNF IL1B
35	positive regulation of neuroinflammatory response	GO:0150078	9.58	TNF IL6 IL1B
36	positive regulation of cell division	GO:0051781	9.56	TGFB1 IL1B IL1A FGF2
37	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.55	TNF IL1B
38	fever generation	GO:0001660	9.54	IL1B IL1A
39	negative regulation of lipid storage	GO:0010888	9.5	TNF IL6 CRP
40	positive regulation of vascular endothelial growth factor production	GO:0010575	9.26	TGFB1 IL6 IL1B IL1A
41	inflammatory response	GO:0006954	9.17	TNF TGFB1 IL6 IL1B IL1A CRP

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor binding	GO:0005149	9.32	IL1B IL1A
2	sodium:potassium-exchanging ATPase activity	GO:0005391	9.26	ATP4A ATP12A
3	cytokine activity	GO:0005125	9.17	TNF TGFB1 IL6 IL1B IL1A FGF2
4	potassium-transporting ATPase activity	GO:0008556	9.16	ATP4A ATP12A
5	potassium:proton exchanging ATPase activity	GO:0008900	8.96	ATP4A ATP12A

Sources

Sources for Laryngitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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¹⁰ dbSNP

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²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Laryngitis

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Classifications:

External Ids:

Summaries for Laryngitis

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Laryngitis:

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:

MGI Mouse Phenotypes related to Laryngitis:

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

Publications for Laryngitis

Articles related to Laryngitis:

Genes for Laryngitis

Genes related to Laryngitis (0 elite genes):

Variations for Laryngitis

Expression for Laryngitis

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

Sources for Laryngitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :