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MCID: LRY019
MIFTS: 52

Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Laryngitis

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MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 12 43 15 71
Acute Laryngitis 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3437
MeSH 43 D007827
NCIt 49 C26811
SNOMED-CT 67 45913009
UMLS 71 C0001327 C0023067
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Summaries for Laryngitis

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Disease Ontology : 12 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and laryngeal tuberculosis, and has symptoms including throat irritation An important gene associated with Laryngitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Fluticasone and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

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Related Diseases for Laryngitis

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Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1723)
# Related Disease Score Top Affiliating Genes
1 acute laryngitis 34.4 ATP4A ATP12A
2 laryngeal tuberculosis 34.1 ATP4A ATP12A
3 chronic laryngitis 33.8 LVRN HRH2 ATP4A ATP12A
4 viral laryngitis 33.6 CRP CD40LG ATP12A
5 gastroesophageal reflux 31.6 TNF TGFB1 IL6 IL1B HRH2 ATP4A
6 tracheitis 31.6 TNF IL6 CRP
7 pulmonary tuberculosis 31.0 TNF IL6 IL1B CRP
8 sudden infant death syndrome 30.8 TNF IL6 IL1B IL1A
9 ankylosis 30.6 TNF TGFB1 CRP
10 sleep apnea 30.6 TNF IL6 IL1B CRP
11 esophagitis 30.6 TNF TGFB1 IL6 IL1B HRH2
12 neuritis 30.6 TNF IL6 IL1B
13 pulmonary edema 30.6 TNF IL1B CRP
14 blastomycosis 30.5 TNF IL6 CD40LG
15 neuroma 30.5 TGFB1 IL6 FGF2
16 diphtheria 30.4 TNF IL1B CD40LG
17 aspergillosis 30.4 TNF IL6 IL1B IL1A
18 spondylitis 30.4 TNF IL6 CRP
19 candidiasis 30.3 TNF IL6 IL1B CD40LG
20 amyloidosis 30.3 TNF IL6 IL1B CRP CD40LG
21 fibrosarcoma 30.2 TNF TGFB1 IL1A FGF2
22 varicose veins 30.2 TNF IL6 FGF2
23 myositis 30.2 TNF IL6 IL1B IL1A
24 gout 30.2 TNF IL6 IL1B
25 dermatitis 30.2 TNF IL6 IL1B IL1A
26 pemphigus 30.2 TNF IL6 CD40LG
27 lymphadenitis 30.1 TNF IL1B CRP
28 visceral leishmaniasis 30.1 TNF IL1B CRP
29 herpes zoster 30.1 TNF CRP CD40LG
30 tonsillitis 30.1 TNF IL6 IL1B IL1A
31 mediastinitis 30.1 CRP ATP4A ATP12A
32 post-transplant lymphoproliferative disease 30.1 TNF IL6 IL1A
33 extrapulmonary tuberculosis 30.1 TNF IL1B IL1A CRP
34 leishmaniasis 30.1 TNF TGFB1 IL6 IL1B IL1A CRP
35 cytomegalovirus infection 30.0 TNF IL6 IL1B
36 fasciitis 30.0 TNF IL6 CRP
37 aspiration pneumonia 30.0 IL6 CRP CD40LG ATP4A ATP12A
38 osteomyelitis 30.0 TNF IL6 IL1B IL1A
39 chickenpox 30.0 TNF IL6 CRP CD40LG
40 sarcoidosis 1 30.0 TNF IL1B IL1A CRP CD40LG
41 syphilis 30.0 TNF IL6 CRP CD40LG
42 arteriovenous malformation 30.0 TNF IL6 IL1B
43 endocarditis 30.0 TNF IL6 IL1A CRP
44 cutaneous leishmaniasis 30.0 TNF IL6 IL1B
45 arthritis 30.0 TNF TGFB1 IL6 IL1B IL1A CRP
46 pertussis 30.0 TNF IL6 IL1B IL1A
47 esophageal cancer 30.0 TNF TGFB1 IL6 IL1B FGF2 CRP
48 mononeuropathy 30.0 TNF CRP CD40LG
49 paracoccidioidomycosis 30.0 TNF IL6 CD40LG
50 vasculitis 29.9 TNF IL6 CRP CD40LG

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis
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Symptoms & Phenotypes for Laryngitis

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UMLS symptoms related to Laryngitis:


throat irritation

GenomeRNAi Phenotypes related to Laryngitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD40LG DNASE1 IL1A IL1B TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 DNASE1 IL1B TGFB1 TNF

MGI Mouse Phenotypes related to Laryngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ATP12A ATP4A CD40LG CRP DNASE1 FGF2
2 cardiovascular system MP:0005385 9.91 CD40LG CRP DNASE1 FGF2 IL1A IL1B
3 immune system MP:0005387 9.65 ATP4A CD40LG CRP DNASE1 IL1A IL1B
4 neoplasm MP:0002006 9.17 ATP4A FGF2 IL1A IL1B IL6 TGFB1
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Drugs & Therapeutics for Laryngitis

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Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
4
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
5
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
6
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
7 Adrenergic Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 Respiratory System Agents Phase 4
10
Salmeterol xinafoate Phase 4 94749-08-3 56801
11 Adrenergic beta-Agonists Phase 4
12 Anti-Allergic Agents Phase 4
13 Hormones Phase 4
14 Fluticasone-Salmeterol Drug Combination Phase 4
15 Hormone Antagonists Phase 4
16 Dermatologic Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Anti-Asthmatic Agents Phase 4
19 glucocorticoids Phase 4
20 Sympathomimetics Phase 4
21 Bronchodilator Agents Phase 4
22 Cyclooxygenase 2 Inhibitors Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Anti-Inflammatory Agents Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Antirheumatic Agents Phase 4
27
Rabeprazole Approved, Investigational Phase 2, Phase 3 117976-89-3 5029
28
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
29
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
30 Antidepressive Agents Phase 2, Phase 3
31 Psychotropic Drugs Phase 2, Phase 3
32 Analgesics, Non-Narcotic Phase 2, Phase 3
33 Analgesics Phase 2, Phase 3
34 Antipsychotic Agents Phase 2, Phase 3
35 Antidepressive Agents, Tricyclic Phase 2, Phase 3
36 Amitriptyline, perphenazine drug combination Phase 2, Phase 3
37
Peppermint Approved Phase 1, Phase 2
38 Oregano Approved Phase 1, Phase 2
39
Rosemary Experimental Phase 1, Phase 2
40 Eucalyptus Phase 1, Phase 2
41 Narcotics Phase 2
42
Nitric Oxide Approved Phase 1 10102-43-9 145068
43 Antioxidants Phase 1
44 Endothelium-Dependent Relaxing Factors Phase 1
45 Vasodilator Agents Phase 1
46 Protective Agents Phase 1
47
Epinephrine Approved, Vet_approved 51-43-4 5816
48
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
49
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
50
Racepinephrine Approved 329-65-7 838

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Pilot Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID as Assessed by the Development of Laryngitis and Oropharyngeal Candidiasis in Adults With Mild Persistent Asthma Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 A Multicenter, Double -Blind, Placebo-controlled Study to Evaluate the Effects of Esomeprazole 40mg Bid on the Signs and Symptoms of Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
3 Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
4 Laryngopharyngeal Reflux Health Related Quality of Life (LPR-HRQL) Questionnaire Development and Psychometric Testing in Patients Receiving Omeprazole 20 mg Bid as Treatment for Laryngopharyngeal Reflux. Completed NCT00641264 Phase 4 Omeprazole
5 Do Laryngeal Biopsy Findings Predict Treatment Response in Suspected Laryngopharyngeal Reflux Completed NCT00444145 Phase 4 Prevacid
6 Role of Esophageal and Laryngeal Biopsies in Suspected Laryngopharyngeal Reflux Completed NCT00373997 Phase 4
7 A Randomized, Placebo-Controlled Assessment of Lansoprazole 30 mg Bid in the Treatment of Gastroesophageal Reflux Associated With Laryngitis Terminated NCT00369265 Phase 4 Lansoprazole
8 A New Nasopharyngeal pH Probe for Diagnosis of Laryngopharyngeal Reflux Withdrawn NCT01308502 Phase 4
9 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
10 A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Alginos Oral Suspension (Sodium Alginate 50 mg/ml) for the Treatment of Patients With Laryngopharyngeal Reflux (LPR) Completed NCT01450748 Phase 3 Sodium alginate;Placebo
11 Identification of Molecular Markers of Inflammatory Mediators in Posterior Laryngitis Due to Laryngopharyngeal Reflux and Evolution With PPI Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
12 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
13 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
14 Effect of Aggressive Acid Suppression With Esomeprazole on Vocal Cord Granulomas: Randomized Placebo-Controlled Trial Withdrawn NCT00567658 Phase 3 Esomeprazole
15 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Some Aromatic Medical Plants. Completed NCT00611390 Phase 1, Phase 2
16 Post-nasal Drainage as an Extraesophageal Manifestation of Reflux Completed NCT00199953 Phase 2 Rabeprazole 20 mg twice a day for 90-day period treatment
17 Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases Recruiting NCT04218617 Phase 2
18 Comparison of GERD and the Effects of Anti-Reflux Therapy on Pulmonary Function Between Able-Bodied and SCI Individuals Unknown status NCT02584751 Phase 1 Omeprazole
19 A Prospective Evaluation of the Utility, Optimal Cutoff and Positive Predictive Value of a Pharyngeal pH Probe for Predicting Proton Pump Inhibitor Response in Treatment Naive Laryngopharyngeal Reflux Unknown status NCT01755221
20 Role of Ultrasound in Diagnosis of Laryngeal Lesions Unknown status NCT03450694
21 Comparison Between Inhaled Budesonide and Intravenous Dexamethasone Treatments for Postextubation Stridor in Children Unknown status NCT02056379 Budesonide;Dexamethasone
22 Non Interventional Study Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
23 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Rabeprazole 20mg twice daily
24 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis: Final Results Completed NCT01389401 omeprazole
25 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
26 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
27 Inter-rater Reliability of the Reflux Finding Score Based on Endoscopic Laryngeal Findings in the Diagnosis of Laryngopharyngeal Reflux Disease Completed NCT02048449
28 ADHERE Study: Application of Dx-pH Catheter for Extra-esophageal Reflux Evaluation Completed NCT00388453
29 DUAL BRAVO PH MONITORING: A Feasibility Trial Completed NCT00378898
30 ELVIS (Esophagitis-Laparoscopy Versus Inhibitors of Secretion) A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication (LNF) Versus Omeprazole for Treatment of Patients With Chronic Gastro-Esophageal Reflux Disease (GERD) Completed NCT00182260 Proton Pump Inhibitors
31 The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold: a Randomized Trial Completed NCT03309995
32 Polish Mother and Child Cohort Study (REPRO_PL).Follow up of the Children. Completed NCT01861548
33 The Diagnostics of Extraesophageal Reflux With the Restech System in Patients With Chronic Rhinosinusitis Completed NCT01819454
34 Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit Recruiting NCT04165356
35 Impact of Chronic Rhinosinusitis on the Laryngeal Mucosa and Voice Quality in Children Aged From 6- to 18- Years Old Not yet recruiting NCT03696693
36 Does Gastric Reflux Induce Sinonasal Symptoms? Not yet recruiting NCT04105894 medical treatment of GERD t

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Guaifenesin

Cochrane evidence based reviews: laryngitis

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Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

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MalaCards organs/tissues related to Laryngitis:

40
Testes, Lung, Brain, Tonsil, Trachea, Heart, Colon
Sources

Publications for Laryngitis

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Articles related to Laryngitis:

(show top 50) (show all 1722)
# Title Authors PMID Year
1
Dual-time-point PET/CT study protocol can improve the larynx cancer diagnosis. 61
32477019 2020
2
Association of voice and mental health diagnoses with differences in voice-related care utilization. 61
31508825 2020
3
Clinical characteristics of herpes zoster laryngitis. 61
32506144 2020
4
A Novel ALK-THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. 61
31368077 2020
5
Screening of BHK-21 cellular proteins that interact with outer membrane protein 43K OMP of Fusobacterium necrophorum. 61
32247918 2020
6
An up-to-date review on bio-resource therapeutics effective against bacterial species frequently associated with chronic sinusitis and tonsillitis. 61
32368971 2020
7
Extranasal Manifestations of Allergy in the Head and Neck. 61
32430587 2020
8
Usefulness of Pep-Test for Laryngo-Pharyngeal Reflux: A Pilot Study in Primary Care. 61
32460472 2020
9
Seasonal Variations in Public Inquiries into Laryngitis: An Infodemiology Study. 61
32439216 2020
10
Idiopathic Ulcerative Laryngitis: A National Survey of Academic Laryngologists. 61
32345504 2020
11
Laryngeal chondritis as a differential for upper airway diseases in German sheep. 61
32131871 2020
12
Validation of the Brazilian Portuguese Version of the Reflux Finding Score. 61
32057613 2020
13
Scrophularia koraiensis Nakai Attenuates Allergic Airway Inflammation via Suppression of NF-κB and Enhancement of Nrf2/HO-1 Signaling. 61
31991647 2020
14
Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. 61
32024037 2020
15
Characteristics and Voice Outcomes of Ulcerative Laryngitis. 61
30170913 2020
16
Determinants of successful tracheostomy decannulation in children: a multicentric cohort study. 61
31910909 2020
17
Effects of Particle Size of Inhaled Corticosteroid on the Voice. 61
31902681 2020
18
Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study. 61
31567786 2019
19
Aspects concerning patient adherence to anti-TNFα therapy in psoriasis: A decade of clinical experience. 61
31798720 2019
20
A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis. 61
31805893 2019
21
Vocal Characteristics of School-Aged Children With and Without Attention Deficit Hyperactivity Disorder. 61
30115579 2019
22
Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis. 61
31120608 2019
23
Leukoplakia or LPR: The Misdiagnosis of Laryngeal Tuberculosis. 61
31779475 2019
24
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. 61
30912581 2019
25
Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom Index. 61
31586513 2019
26
Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review. 61
31670624 2019
27
Herpes Zoster Laryngitis with Disseminated Cutaneous Lesions. 61
31243199 2019
28
Vocal Characteristics of Patients With Morbid Obesity. 61
31648859 2019
29
Isolated Laryngeal Leishmaniasis: A Diagnostic Dilemma. 61
31742085 2019
30
A Comprehensive Analysis of Benign Vocal Fold Lesions Causing Hoarseness of Voice and Our Experience with Cold Knife Endolaryngeal Surgery in a Tertiary Healthcare Centre. 61
31742013 2019
31
The Role of Allergy in Phonation. 61
30145066 2019
32
The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. 61
31533753 2019
33
Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria. 61
31546651 2019
34
Updates in the field of non-esophageal gastroesophageal reflux disorder. 61
31322443 2019
35
Characteristics of swallowing disorders in patients with dysphonia. 61
32022701 2019
36
Reaction to Clindamycin Causing Laryngitis and Esophagitis. 61
31569974 2019
37
A review for the neuroprotective effects of andrographolide in the central nervous system. 61
31181444 2019
38
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology. 61
29884508 2019
39
Acute supraglottic laryngitis complicated by vocal fold immobility: prognosis and management. 61
31214824 2019
40
Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults. 61
31415057 2019
41
Identification and Management of Chronic Laryngitis. 61
31101358 2019
42
Can the Reflux Finding Score and Reflux Symptom Index Be Used to Evaluate the Severity of Esophagitis in Children? 61
31447186 2019
43
Characteristics of a Treatment-seeking Population in a Private Practice Community Voice Clinic: An Epidemiologic Study. 61
29310885 2019
44
Allergic laryngitis: chronic laryngitis and allergic sensitization. 61
30898484 2019
45
Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity. 61
30678486 2019
46
Airflow Patterns of Running Speech in Patients With Voice Disorders. 61
30057271 2019
47
A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx. 61
31104410 2019
48
A comparative and correlative study of the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) for voice-related quality of life among teachers with and without voice disorders. 61
30817565 2019
49
[Influence of TNF-α on the immunomodulatory property of laryngeal mucosa mesenchymal stromal cells']. 61
30909341 2019
50
Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan. 61
30928919 2019
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Variations for Laryngitis

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Expression for Laryngitis

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Search GEO for disease gene expression data for Laryngitis.
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Pathways for Laryngitis

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Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 13.39 TNF TGFB1 IL6 IL1B IL1A FGF2
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.34 TNF TGFB1 IL6 IL1B IL1A FGF2
3
PAK Pathway 63
Show member pathways
 13.28 TNF TGFB1 IL6 IL1B IL1A FGF2
4
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13.27 TNF TGFB1 IL6 IL1B IL1A ATP4A
5
Allograft rejection 1 36
Show member pathways
 12.83 TNF TGFB1 IL6 IL1B IL1A CD40LG
6
MAPK signaling pathway 36 1
12.75 TNF TGFB1 IL1B IL1A FGF2
7
Th17 cell differentiation 36
Show member pathways
 12.59 TNF TGFB1 IL6 IL1B IL1A
8
T cell receptor signaling pathway 36
Show member pathways
 12.57 TNF TGFB1 IL6 IL1B IL1A CD40LG
9
NF-KappaB Family Pathway 63
Show member pathways
 12.57 TNF TGFB1 IL6 IL1B IL1A FGF2
10
Folate Metabolism 1
Show member pathways
 12.33 TNF IL6 IL1B CRP
11
Toll Comparative Pathway 63
Show member pathways
 12.31 TNF IL6 IL1B IL1A FGF2
12
Toxoplasmosis 36
Show member pathways
 12.25 TNF TGFB1 IL1B IL1A CD40LG
13
Tuberculosis 36
12.22 TNF TGFB1 IL6 IL1B IL1A
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.22 TNF TGFB1 IL6 IL1B IL1A FGF2
15
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 TNF IL6 IL1B IL1A
16
Osteoclast differentiation 36
12.05 TNF TGFB1 IL1B IL1A
17
Senescence and Autophagy in Cancer 1
11.96 TGFB1 IL6 IL1B IL1A
18
IL27-mediated signaling events 1
Show member pathways
 11.95 TNF TGFB1 IL6 IL1B
19
Spinal Cord Injury 1
11.95 TNF TGFB1 IL6 IL1B IL1A
20
Amoebiasis 36
11.93 TNF TGFB1 IL6 IL1B
21
NF-kappa B signaling pathway 36
11.9 TNF IL1B CD40LG
22
Hematopoietic cell lineage 36
11.9 TNF IL6 IL1B IL1A
23
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.86 TGFB1 IL6 FGF2
24
Th17 Differentiation 64
Show member pathways
 11.84 TGFB1 IL6 IL1B
25
AGE-RAGE signaling pathway in diabetic complications 36
11.83 TNF TGFB1 IL6 IL1B IL1A
26
Pertussis 36
11.77 TNF IL6 IL1B IL1A
27
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF TGFB1 IL6 IL1B
28
Rheumatoid arthritis 36
11.73 TNF TGFB1 IL6 IL1B IL1A
29
Legionellosis 36
11.62 TNF IL6 IL1B
30
Hematopoietic Stem Cell Differentiation 1
11.54 IL6 IL1B IL1A
31
Differentiation Pathway 1
11.53 TGFB1 IL6 FGF2
32
Aryl Hydrocarbon Receptor Pathway 1
11.53 TNF TGFB1 IL1B
33
Interleukin-10 signaling 65
11.52 TNF IL6 IL1B IL1A
34
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.52 TNF IL6 IL1B IL1A CD40LG
35
Interleukin-4 and 13 signaling 65
11.49 TNF TGFB1 IL6 IL1B IL1A FGF2
36
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.45 TNF IL6 IL1B IL1A
37
Lung fibrosis 1
11.45 TNF TGFB1 IL6 IL1B FGF2
38
African trypanosomiasis 36
11.4 TNF IL6 IL1B
39
Prion diseases 36
11.37 IL6 IL1B IL1A
40
Development and heterogeneity of the ILC family 1
11.33 TNF IL6 IL1B
41
Antifolate resistance 36
11.31 TNF IL6 IL1B
42
IL-10 Pathway 63
11.3 TNF IL6 IL1B IL1A
43
Malaria 36
11.25 TNF TGFB1 IL6 IL1B CD40LG
44
Overview of nanoparticle effects 1
11.05 TNF IL6 CRP
45
G-protein signaling_Rap2B regulation pathway 22
10.96 TNF TGFB1 IL6 IL1B IL1A FGF2
46
RXR and RAR heterodimerization with other nuclear receptor 1
10.85 TNF TGFB1
47
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.81 TGFB1 IL6 IL1B
48
Interleukin-1 processing 65
10.54 IL1B IL1A
49
Cytokines and Inflammatory Response 1
10.48 TNF TGFB1 IL6 IL1B IL1A
50
Secretion of Hydrochloric Acid in Parietal Cells 1
10.38 HRH2 ATP4A
Sources

GO Terms for Laryngitis

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Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TTLL1 TNF TGFB1 IL6 IL1B IL1A
2 extracellular space GO:0005615 9.32 TNF TGFB1 MIR500A IL6 IL1B IL1A

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.08 TNF TGFB1 IL6 IL1B FGF2
2 MAPK cascade GO:0000165 9.97 TNF TGFB1 IL1B FGF2
3 immune response GO:0006955 9.95 TNF IL6 IL1B IL1A HRH2 CD40LG
4 positive regulation of gene expression GO:0010628 9.93 TNF TGFB1 IL6 IL1B IL1A CRP
5 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL6 IL1B IL1A
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 TNF TGFB1 IL6
7 cellular response to organic cyclic compound GO:0071407 9.83 TNF TGFB1 IL1B
8 positive regulation of MAP kinase activity GO:0043406 9.83 TNF TGFB1 FGF2
9 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL1B CD40LG
10 positive regulation of interleukin-6 production GO:0032755 9.81 TNF IL6 IL1B
11 negative regulation of fat cell differentiation GO:0045599 9.79 TNF TGFB1 IL6
12 negative regulation of blood vessel endothelial cell migration GO:0043537 9.78 TNF TGFB1 FGF2
13 positive regulation of epithelial to mesenchymal transition GO:0010718 9.77 TGFB1 IL6 IL1B
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 TNF TGFB1 IL6 IL1B CD40LG
15 positive regulation of interleukin-6 secretion GO:2000778 9.75 TNF IL1B IL1A
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.74 TNF TGFB1 FGF2
17 protein kinase B signaling GO:0043491 9.73 TNF TGFB1 IL1B
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.7 TNF IL1B IL1A
19 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.69 IL1B IL1A
20 sodium ion export across plasma membrane GO:0036376 9.69 ATP4A ATP12A
21 cellular potassium ion homeostasis GO:0030007 9.69 ATP4A ATP12A
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TNF TGFB1 IL1B
23 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.68 ATP4A ATP12A
24 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF IL1B
25 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.67 TGFB1 IL6
26 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.67 TNF TGFB1
27 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
28 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
29 ectopic germ cell programmed cell death GO:0035234 9.65 IL1B IL1A
30 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF TGFB1
31 regulation of immunoglobulin secretion GO:0051023 9.63 TNF CD40LG
32 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
33 cytokine-mediated signaling pathway GO:0019221 9.63 TNF TGFB1 IL6 IL1B IL1A FGF2
34 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.62 TGFB1 IL1A
35 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
36 positive regulation of immature T cell proliferation in thymus GO:0033092 9.59 IL1B IL1A
37 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
38 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
39 positive regulation of cell division GO:0051781 9.56 TGFB1 IL1B IL1A FGF2
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 TNF IL1B
41 fever generation GO:0001660 9.54 IL1B IL1A
42 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
43 positive regulation of vascular endothelial growth factor production GO:0010575 9.26 TGFB1 IL6 IL1B IL1A
44 inflammatory response GO:0006954 9.17 TNF TGFB1 IL6 IL1B IL1A CRP

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 cytokine activity GO:0005125 9.17 TNF TGFB1 IL6 IL1B IL1A FGF2
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
Sources

Sources for Laryngitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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