MCID: LRY002
MIFTS: 37

Laryngostenosis

Categories: Oral diseases, Respiratory diseases
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Aliases & Classifications for Laryngostenosis

MalaCards integrated aliases for Laryngostenosis:

Name: Laryngostenosis 11 43 14 71 33
Stenosis of Larynx 11 31 33
Laryngeal Stricture 33
Laryngeal Stenosis 33
Larynx Stricture 33
Larynx Narrowing 33
Larynx Stenosis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:11527
ICD9CM 34 478.74
MeSH 43 D007829
NCIt 49 C79608
SNOMED-CT 68 195864007
ICD10 31 J38.6
ICD11 33 803766116
UMLS 71 C0023075

Summaries for Laryngostenosis

MalaCards based summary: Laryngostenosis, also known as stenosis of larynx, is related to epidermolysis bullosa dystrophica and granulomatosis with polyangiitis. An important gene associated with Laryngostenosis is FREM1 (FRAS1 Related Extracellular Matrix 1), and among its related pathways/superpathways are C-MYB transcription factor network and Development of ureteric collection system. The drugs Ixekizumab and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include trachea, adrenal cortex and thyroid, and related phenotype is Synthetic lethal with Ras.

Related Diseases for Laryngostenosis

Diseases related to Laryngostenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa dystrophica 29.8 FREM2 FREM1
2 granulomatosis with polyangiitis 29.5 PRTN3 MPO
3 polyarteritis nodosa 29.4 PRTN3 MPO
4 exanthem 29.4 PRTN3 MPO
5 thoracolaryngopelvic dysplasia 11.2
6 epidermolysis bullosa 10.2
7 pemphigoid 10.2
8 cicatricial pemphigoid 10.2
9 tracheal stenosis 10.2
10 bullous pemphigoid 10.2
11 microphthalmia, syndromic 12 10.1 FREM2 FREM1
12 diaphragm disease 10.1 FREM2 FREM1
13 dacryocystocele 10.1 FREM2 FRAS1
14 chronic inflammation of lacrimal passage 10.1 FREM2 FRAS1
15 congenital symblepharon 10.1 FREM2 FRAS1
16 zygodactyly 1 10.1 FREM2 FRAS1
17 acrorenal syndrome 10.1 FREM2 FRAS1
18 larynx cancer 10.1
19 laryngeal benign neoplasm 10.1
20 gastroesophageal reflux 10.0
21 congenital subglottic stenosis 10.0
22 congenital anomalies of kidney and urinary tract 2 10.0 FREM2 FRAS1
23 papillorenal syndrome 10.0 FREM2 FRAS1
24 anus, imperforate 10.0 FREM2 FRAS1
25 townes-brocks syndrome 10.0 FREM2 FRAS1
26 oligohydramnios 10.0 FREM2 FRAS1
27 skin disease 10.0
28 epidermolysis bullosa acquisita 10.0
29 chromosomal duplication syndrome 9.9 FREM2 FRAS1
30 vesicoureteral reflux 9.9 FREM2 FRAS1
31 blepharophimosis, ptosis, and epicanthus inversus 9.9
32 epicanthus 9.9
33 telecanthus 9.9
34 ptosis 9.9
35 blepharophimosis 9.9
36 microcephaly 9.9
37 hemangioma 9.9
38 papilloma 9.9
39 posttransplant acute limbic encephalitis 9.9
40 diphtheria 9.9
41 acquired tear duct stenosis 9.9 PRTN3 MPO
42 stenosis of lacrimal passage 9.9 PRTN3 MPO
43 allergic cutaneous vasculitis 9.9 PRTN3 MPO
44 pelvic inflammatory disease 9.9 MPO CTSB
45 middle ear cholesterol granuloma 9.9 PRTN3 MPO
46 orbital granuloma 9.9 PRTN3 MPO
47 clivus meningioma 9.9 PRTN3 MPO
48 multiple cranial nerve palsy 9.9 PRTN3 MPO
49 cranial nerve palsy 9.9 PRTN3 MPO
50 posterior scleritis 9.9 PRTN3 MPO

Comorbidity relations with Laryngostenosis via Phenotypic Disease Network (PDN):


Bronchitis Heart Disease
Hypertension, Essential Respiratory Failure

Graphical network of the top 20 diseases related to Laryngostenosis:



Diseases related to Laryngostenosis

Symptoms & Phenotypes for Laryngostenosis

GenomeRNAi Phenotypes related to Laryngostenosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with Ras GR00018-A-0 8.92 CTSB FREM1 MPO PRTN3

Drugs & Therapeutics for Laryngostenosis

Drugs for Laryngostenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ixekizumab Approved, Investigational Phase 2 1143503-69-8
2 Dermatologic Agents Phase 2
3
Mitomycin Approved 50-07-7 5746
4 Anti-Bacterial Agents
5 Alkylating Agents
6 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells Completed NCT03130374 Phase 1, Phase 2
2 Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells Enrolling by invitation NCT05535803 Phase 2
3 Effects of IL-17A Inhibition on Idiopathic Subglottic Stenosis Not yet recruiting NCT05309616 Phase 2 Taltz
4 Phase I/IIa Clinical Trial of Stem Cell Based Tissue Engineered Partial Laryngeal Implants in 10 Adult Patients With End-stage Laryngeal Stenosis With 24 Months Follow-up. Withdrawn NCT01977911 Phase 1, Phase 2
5 The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis Recruiting NCT04734483
6 A Prospective Nonrandomized Study of Laryngeal Allograft Transplantation Clinical Investigation Enrolling by invitation NCT03269396
7 A Randomized Study of Mitomycin-C Application in the Endoscopic Surgical Treatment of Patients With Laryngotracheal Stenosis Terminated NCT01523275 Mitomycin -C

Search NIH Clinical Center for Laryngostenosis

Cochrane evidence based reviews: laryngostenosis

Genetic Tests for Laryngostenosis

Anatomical Context for Laryngostenosis

Organs/tissues related to Laryngostenosis:

MalaCards : Trachea, Adrenal Cortex, Thyroid, Lung, Bone, Cortex, Skin

Publications for Laryngostenosis

Articles related to Laryngostenosis:

(show top 50) (show all 620)
# Title Authors PMID Year
1
Laryngeal function-preserving of frontolateral vertical partial laryngectomy (FLVPL) for selected T4a glottic cancer with thyroid cartilage invasion adherence to the anterior commissure: an innovative attempt. 62
35680654 2022
2
COVID-19 Omicron variant-induced laryngitis. 62
36114072 2022
3
Supraglottic Localization of IgG4-Related Disease-Rare and Challenging Equity. 62
36013172 2022
4
Surgical Tracheostomy in a COVID-19 Positive Patient: A Case Study. 62
35951234 2022
5
Chronic care handoffs in otolaryngology: Pediatric to Adult Care Providers. 62
35489229 2022
6
Possibilities of coblation in otorhinolaryngology: analytical review. 62
34482444 2022
7
What are the Soft Tissue Risk Factors for Obstructive Sleep Apnea in Patients with Down's Syndrome? 62
35306875 2022
8
Fetoscopic Balloon Dilation and Stent Placement of Congenital High Airway Obstruction Syndrome Leading to Successful Cesarean Delivery. 62
34999582 2022
9
[A non-standard approach in the treatment of post-traumatic multifocal cicatricial tracheal stenosis with atresia of subglottic larynx, involvement of vocal cords and 33-year cannulation]. 62
36107191 2022
10
[Cochlear implant and surgical intervention for CHARGE syndrome with laryngeal airway lesions]. 62
34886607 2021
11
Use of monopolar microelectrodes and radiofrequency in the treatment of arytenoid edema after partial horizontal laryngectomy and radiotherapy. 62
34309107 2021
12
The natural history of laryngo-onycho-cutaneous syndrome: A case series of six pediatric patients and literature review. 62
34514630 2021
13
Endoscopic Posterior Cricoid Split and Rib Graft Without Tracheostomy: Case and Literature Review. 62
33595125 2021
14
Balloon dilation laryngoplasty for acquired subglottic stenosis at a tertiary center in India. 62
34471614 2021
15
[Feasibility and efficacy of a thyroid cartilage window technique for transoral CO₂ laser resection of early glottic cancer involving the anterior commissure]. 62
34304530 2021
16
Decreasing tracheostomy placement in hospitalized pediatric patients with subglottic stenosis - Kids' Inpatient Database (KID) analysis. 62
33992971 2021
17
Airway Fire during Laser Surgery of the Vocal Cords in Children: A Case Report. 62
35110148 2021
18
Acute laryngeal lesions following endotracheal intubation: Risk factors, classification and treatment. 62
34172219 2021
19
[Analyses of diagnosis and treatment of laryngeal stenosis caused by explosion and corrosion in children]. 62
34304475 2021
20
Awake Laser Laryngeal Stenosis Surgery. 62
33264421 2021
21
Radiotherapy versus partial laryngectomy in the management of early glottic cancer with anterior commissure involvement: A propensity score matched study with 256 patients. 62
33647869 2021
22
[Analysis of related factors of postoperative complications of Juvenile-onset recurrent respiratory papillomatosis]. 62
33794627 2021
23
Subglottic Stenosis Position Affects Work of Breathing. 62
33280109 2021
24
[Diagnosis and endoscopic treatment of blunt laryngeal trauma with arytenoid injury]. 62
33730809 2021
25
Endoscopic Z-plasty for Treatment of Supraglottic Stenosis: Experience on Nine Patients. 62
32533778 2021
26
Laryngotracheobronchial amyloidosis: A case report. 62
33747762 2021
27
The Incidence of Pediatric Tracheostomy and Its Association Among Black Children. 62
32777978 2021
28
Transoral management of adult benign laryngeal stenosis. 62
32705360 2021
29
[Laryngeal cysts in children]. 62
34964331 2021
30
The Role of Cytokines in Modulating Vocal Fold Fibrosis: A Contemporary Review. 62
32293731 2021
31
A series of unfortunate events: Mind the windpipe. 62
33362930 2021
32
Acquired subglottic cysts in children: A rare and challenging clinical entity. A systematic review. 62
33261859 2021
33
[Efficacy of acellular dermis matrix combined with cervical strap muscle as a composite tissue flap for the treatment of laryngeal cancer]. 62
33342128 2020
34
Novel application of AIRVO™ 2 for the management of postoperative hypoxemia due to severe laryngeal stenosis. 62
32464477 2020
35
Outcomes of balloon dilation for paediatric laryngeal stenosis. 62
33299226 2020
36
Laryngeal Tuberculosis in a Patient on Avelumab for Metastatic Nasopharyngeal Carcinoma. 62
32780576 2020
37
30-Day readmission rates, diagnoses, and risk factors following pediatric airway surgery. 62
32554136 2020
38
["Point line anterograde dissection" for the safe preparation of supraclavicular flap]. 62
32911887 2020
39
Management of mucous membrane pemphigoid in a joint oral medicine-dermatology clinic. 62
32003042 2020
40
Laryngeal stenosis associated with epidermolysis bullosa simplex. 62
32395601 2020
41
Congenital Laryngeal Stenosis and Concomitant Birth Defects in a Term Newborn: A Case Report. 62
32884930 2020
42
Isolated stridor without any other sleeping breathing disorder diagnosed using drug-induced sleep endoscopy in a patient with multiple system atrophy: A case report. 62
32311969 2020
43
Laryngeal stent for acute and chronic respiratory distress in seven dogs with laryngeal paralysis. 62
32426250 2020
44
Is a voice-specific instrument more indicative of stroboscopy results than common clinical queries? 62
31418872 2020
45
Respiratory scleroma: A clinicopathologic study of 51 cases from Guatemala. 62
31869492 2020
46
Salvage open partial horizontal laryngectomy after failed radiotherapy: A multicentric study. 62
31046149 2020
47
The Antiproliferative and Antifibrotic Effects of Cisplatin on Primary Human Vocal Fold Fibroblasts. 62
32268330 2020
48
Laryngeal Diffuse Large B-Cell Lymphoma Presenting as Laryngeal Stenosis. 62
31882486 2020
49
Ongoing Laryngeal Stenosis: Conservative Management and Alternatives to Tracheostomy. 62
32351919 2020
50
[Congenital laryngeal paralysis in children]. 62
32241985 2020

Variations for Laryngostenosis

Expression for Laryngostenosis

Search GEO for disease gene expression data for Laryngostenosis.

Pathways for Laryngostenosis

Pathways related to Laryngostenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 PRTN3 MPO
2 10.28 FREM1 FRAS1
3 10.23 FREM2 FREM1 FRAS1

GO Terms for Laryngostenosis

Cellular components related to Laryngostenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 9.43 FREM2 FREM1 FRAS1
2 collagen-containing extracellular matrix GO:0062023 9.32 PRTN3 FREM2 FREM1 FRAS1 CTSB

Biological processes related to Laryngostenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.56 PRTN3 CTSB
2 morphogenesis of an epithelium GO:0002009 9.46 FREM2 FRAS1
3 anatomical structure morphogenesis GO:0009653 9.43 FREM2 FREM1 FRAS1
4 cell communication GO:0007154 9.1 FREM2 FREM1 FRAS1

Sources for Laryngostenosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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