MCID: LRY002
MIFTS: 15

Laryngostenosis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngostenosis

MalaCards integrated aliases for Laryngostenosis:

Name: Laryngostenosis 12 44 15 73
Stenosis of Larynx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11527
ICD10 33 J38.6
ICD9CM 35 478.74
MeSH 44 D007829
NCIt 50 C79608
SNOMED-CT 68 75547007
UMLS 73 C0023075

Summaries for Laryngostenosis

MalaCards based summary : Laryngostenosis, also known as stenosis of larynx, is related to diphtheria. An important gene associated with Laryngostenosis is FOXL2 (Forkhead Box L2). The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include trachea.

Related Diseases for Laryngostenosis

Diseases related to Laryngostenosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diphtheria 9.8

Comorbidity relations with Laryngostenosis via Phenotypic Disease Network (PDN):


Bronchitis Heart Disease
Hypertension, Essential Respiratory Failure

Symptoms & Phenotypes for Laryngostenosis

Drugs & Therapeutics for Laryngostenosis

Drugs for Laryngostenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
2
rituximab Approved Phase 3 174722-31-7 10201696
3 Alkylating Agents Phase 3,Not Applicable
4 Antineoplastic Agents, Alkylating Phase 3
5 Immunosuppressive Agents Phase 3
6 Antirheumatic Agents Phase 3
7 Immunologic Factors Phase 3
8
Olaparib Approved Phase 1 763113-22-0 23725625
9 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
10
Temazepam Approved, Investigational Not Applicable 846-50-4 5391
11 Antibiotics, Antitubercular Not Applicable
12 Anti-Bacterial Agents Not Applicable
13 Nucleic Acid Synthesis Inhibitors Not Applicable
14 Mitomycins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid Not yet recruiting NCT03295383 Phase 3 Rituximab 1g IV;Cyclophosphamide 50Mg Oral Tablet;Placebo of Rituximab;Placebo Oral Tablet
2 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Active, not recruiting NCT03130374 Phase 1, Phase 2
3 Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management Not yet recruiting NCT03760354 Phase 2 Methylprednisolone
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Withdrawn NCT01977911 Phase 1, Phase 2
5 Olaparib and Radiotherapy in Head and Neck Cancer Recruiting NCT02229656 Phase 1 Olaparib
6 Study of Mitomycin-C Application in Laryngotracheal Stenosis Unknown status NCT01523275 Not Applicable Mitomycin -C
7 Functional Modeling of the Pediatric Airway Completed NCT01690078
8 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
9 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Active, not recruiting NCT02481817
10 Laryngeal Allograft Transplantation Enrolling by invitation NCT03269396 Not Applicable

Search NIH Clinical Center for Laryngostenosis

Cochrane evidence based reviews: laryngostenosis

Genetic Tests for Laryngostenosis

Anatomical Context for Laryngostenosis

MalaCards organs/tissues related to Laryngostenosis:

41
Trachea

Publications for Laryngostenosis

Articles related to Laryngostenosis:

# Title Authors Year
1
Severe feeding problems and congenital laryngostenosis in a patient with 3q23 deletion. ( 9266197 )
1997
2
Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13363239 )
1956
3
Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13422506 )
1956
4
Three cases of congenital laryngostenosis with different etiologies. ( 18885519 )
1948
5
Stenosis of Larynx due to Lupus, now being treated by Progressive Dilatation. ( 19988356 )
1931
6
OPERATIVE RELIEF OF LARYNGOSTENOSIS. ( 17865603 )
1927
7
Stenosis of Larynx. ( 19975933 )
1912
8
Complete Stenosis of Larynx left after Diphtheria and Tracheotomy, in a Boy when aged 1 year and 2 months; completely cured by Repeated Intubations spread over Three Years. ( 19974419 )
1910
9
Stenosis of Larynx in a Child. ( 19973689 )
1909

Variations for Laryngostenosis

Expression for Laryngostenosis

Search GEO for disease gene expression data for Laryngostenosis.

Pathways for Laryngostenosis

GO Terms for Laryngostenosis

Molecular functions related to Laryngostenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 8.62 FOXL2 ZBED1

Sources for Laryngostenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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