Laryngostenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Laryngostenosis

MalaCards integrated aliases for Laryngostenosis:

Name: Laryngostenosis ¹² ⁴⁴ ¹⁵ ⁷³

Stenosis of Larynx ¹²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the respiratory system

Other diseases of upper respiratory tract

Diseases of vocal cords and larynx, not elsewhere classified

Stenosis of larynx

External Ids:

Disease Ontology ¹² DOID:11527

ICD10 ³³ J38.6

ICD9CM ³⁵ 478.74

MeSH ⁴⁴ D007829

NCIt ⁵⁰ C79608

SNOMED-CT ⁶⁸ 75547007

UMLS ⁷³ C0023075

Sources

Summaries for Laryngostenosis

MalaCards based summary : Laryngostenosis, also known as stenosis of larynx, is related to diphtheria. An important gene associated with Laryngostenosis is FOXL2 (Forkhead Box L2). The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include trachea.

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Related Diseases for Laryngostenosis

Diseases related to Laryngostenosis via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	diphtheria	9.8

Comorbidity relations with Laryngostenosis via Phenotypic Disease Network (PDN):

Bronchitis	Heart Disease
Hypertension, Essential	Respiratory Failure

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Symptoms & Phenotypes for Laryngostenosis

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Drugs & Therapeutics for Laryngostenosis

Drugs for Laryngostenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cyclophosphamide

Approved, Investigational

Phase 3

6055-19-2, 50-18-0

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CP

CPA

CTX

CY

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Ledoxina

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

2

rituximab

Approved

Phase 3

174722-31-7

10201696

3

Alkylating Agents

Phase 3,Not Applicable

4

Antineoplastic Agents, Alkylating

Phase 3

5

Immunosuppressive Agents

Phase 3

6

Antirheumatic Agents

Phase 3

7

Immunologic Factors

Phase 3

8

Olaparib

Approved

Phase 1

763113-22-0

23725625

Synonyms:

4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one

4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one

4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one

763113-22-0

937799-91-2

Acylpiperazine analogue, 47

AKOS005145764

AZD 2281

AZD2281

AZD-2281

CHEMBL521686

EC-000.2324

EN002690

FT-0083489

KU-0059436

KU-59436

olaparib

Olaparib

Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281

S1060_Selleck

9

Poly(ADP-ribose) Polymerase Inhibitors

Phase 1

10

Temazepam

Approved, Investigational

Not Applicable

846-50-4

5391

Synonyms:

1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

3 Hydroxydiazepam

3-Hydroxydiazepam

5-25-02-00242 (Beilstein Handbook Reference)

7-CHLORO-1,3-DIHYDRO-3-HYDROXY-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE

7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one

846-50-4

AC1L1K92

AHP brand OF temazepam

AHP Brand of Temazepam

Alphapharm brand OF temazepam

Alphapharm Brand of Temazepam

apo Temazepam

Apo Temazepam

apo-Temazepam

Apo-Temazepam

Apotex brand OF temazepam

Apotex Brand of Temazepam

BRN 0759300

CCRIS 1954

Cerepax

CHEMBL967

CID5391

Crisonar

ct Arzneimittel Brand of Temazepam

CT Arzneimittel brand OF temazepam

ct-Arzneimittel Brand of Temazepam

CT-Arzneimittel brand OF temazepam

D00370

D013693

Dasuen

DB00231

DEA No. 2925

Desitin brand OF temazepam

Desitin Brand of Temazepam

DivK1c_000989

EINECS 212-688-1

ER 115

Euhypnos

Euipnos

Gelthix

Gen temazepam

Gen Temazepam

Genopharm brand OF temazepam

Genopharm Brand of Temazepam

Genpharm brand OF temazepam

Genpharm Brand of Temazepam

Gen-temazepam

Gen-Temazepam

HMS503E19

Hydroxydiazepam

ICN brand OF temazepam

ICN Brand of Temazepam

IDI1_000989

K3917

K-3917

Katwijk brand OF temazepam

Katwijk Brand of Temazepam

KBio1_000989

Knoll brand OF temazepam

Knoll Brand of Temazepam

Lenal

Levanxene

Levanxol

Levanzene

LS-7712

Mabertin

Mallinckrodt brand OF temazepam

Mallinckrodt Brand of Temazepam

Methyloxazepam

MolPort-002-051-814

NCGC00159440-02

Neodorm SP

NINDS_000989

N-Methyloxazepam

Nocturne

Nomapam

Norkotral tema

Norkotral Tema

Normison

Normitab

Nortem

Norton brand OF temazepam

Norton Brand of Temazepam

Novartis brand OF temazepam

Novartis Brand of Temazepam

novo Temazepam

Novo Temazepam

Novopharm brand OF temazepam

Novopharm Brand of Temazepam

novo-Temazepam

Novo-Temazepam

NSC 246303

NSC246303

Nu pharm brand OF temazepam

Nu Pharm Brand of Temazepam

Nu temazepam

Nu Temazepam

Nu-pharm brand OF temazepam

Nu-Pharm Brand of Temazepam

Nu-temazepam

Nu-Temazepam

Orion brand OF temazepam

Orion Brand of Temazepam

Oxydiazepam

Perdorm

Pfizer brand 1 OF temazepam

Pfizer Brand 1 of Temazepam

Pfizer brand 2 OF temazepam

Pfizer Brand 2 of Temazepam

Pharmascience brand OF temazepam

Pharmascience Brand of Temazepam

Planum

PMS Temazepam

PMS-Temazepam

Pronervon T

Remestan

Restoril

Restoril (TN)

Ro 5 5345

Ro 5-5345

Ro55345

Ro-5-5345

SaH 47 603

SaH 47603

SaH 47-603

Scheffler brand OF temazepam

Scheffler Brand of Temazepam

Sigma brand OF temazepam

Sigma Brand of Temazepam

Signopam

T8275_FLUKA

T8275_SIGMA

Tema, norkotral

Tema, Norkotral

Temador

Temaz

Temaze

temazep von ct

Temazep von CT

temazepam

Temazepam (USP/INN)

Temazepam [USAN:INN:BAN]

Temazepam, pharmaceutical grade

Temazepamum

Temazepamum [INN-Latin]

Temtabs

Tenox

UNII-CHB1QD2QSS

Uvamin Retard

WLN: T67 GNV JN IHJ CG G1 IQ KR

WY 2917

WY 3917

Wy-3917

WY3917

Wyeth brand OF temazepam

Wyeth Brand of Temazepam

11

Antibiotics, Antitubercular

Not Applicable

12

Anti-Bacterial Agents

Not Applicable

13

Nucleic Acid Synthesis Inhibitors

Not Applicable

14

Mitomycins

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid	Not yet recruiting	NCT03295383	Phase 3	Rituximab 1g IV;Cyclophosphamide 50Mg Oral Tablet;Placebo of Rituximab;Placebo Oral Tablet
2	Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells	Active, not recruiting	NCT03130374	Phase 1, Phase 2
3	Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management	Not yet recruiting	NCT03760354	Phase 2	Methylprednisolone
4	Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants	Withdrawn	NCT01977911	Phase 1, Phase 2
5	Olaparib and Radiotherapy in Head and Neck Cancer	Recruiting	NCT02229656	Phase 1	Olaparib
6	Study of Mitomycin-C Application in Laryngotracheal Stenosis	Unknown status	NCT01523275	Not Applicable	Mitomycin -C
7	Functional Modeling of the Pediatric Airway	Completed	NCT01690078
8	Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence	Recruiting	NCT03423017	Not Applicable
9	Treatment Alternatives in iSGS (NoAAC PR-02 Study)	Active, not recruiting	NCT02481817
10	Laryngeal Allograft Transplantation	Enrolling by invitation	NCT03269396	Not Applicable

Search NIH Clinical Center for Laryngostenosis

Cochrane evidence based reviews: laryngostenosis

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Genetic Tests for Laryngostenosis

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Anatomical Context for Laryngostenosis

MalaCards organs/tissues related to Laryngostenosis:

⁴¹

Trachea

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Publications for Laryngostenosis

Articles related to Laryngostenosis:

#	Title	Authors	Year
1	Severe feeding problems and congenital laryngostenosis in a patient with 3q23 deletion. ( 9266197 )	Chandler K.E....Schrander J.J.	1997
2	Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13363239 )	ERICH JB	1956
3	Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13422506 )	ERICH JB	1956
4	Three cases of congenital laryngostenosis with different etiologies. ( 18885519 )	HAMNE B.	1948
5	Stenosis of Larynx due to Lupus, now being treated by Progressive Dilatation. ( 19988356 )	Howarth W	1931
6	OPERATIVE RELIEF OF LARYNGOSTENOSIS. ( 17865603 )	Schwyzer A.	1927
7	Stenosis of Larynx. ( 19975933 )	Pegler LH	1912
8	Complete Stenosis of Larynx left after Diphtheria and Tracheotomy, in a Boy when aged 1 year and 2 months; completely cured by Repeated Intubations spread over Three Years. ( 19974419 )	Thomson S	1910
9	Stenosis of Larynx in a Child. ( 19973689 )	Faulder TJ	1909

Sources

Genes for Laryngostenosis

Genes related to Laryngostenosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FOXL2	Forkhead Box L2	Protein Coding	15.57	DISEASES inferred ¹⁵
2	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	15.17	DISEASES inferred ¹⁵
3	CTSB	Cathepsin B	Protein Coding	14.84	DISEASES inferred ¹⁵
4	ZBED1	Zinc Finger BED-Type Containing 1	Protein Coding	6.97	DISEASES inferred ¹⁵

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Variations for Laryngostenosis

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Expression for Laryngostenosis

Search GEO for disease gene expression data for Laryngostenosis.

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Pathways for Laryngostenosis

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GO Terms for Laryngostenosis

Molecular functions related to Laryngostenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001077	8.62	FOXL2 ZBED1

Sources

Sources for Laryngostenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia