MCID: LRY002
MIFTS: 20

Laryngostenosis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Laryngostenosis

MalaCards integrated aliases for Laryngostenosis:

Name: Laryngostenosis 12 45 15 74
Stenosis of Larynx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11527
ICD9CM 36 478.74
MeSH 45 D007829
NCIt 51 C79608
SNOMED-CT 69 75547007
ICD10 34 J38.6
UMLS 74 C0023075

Summaries for Laryngostenosis

MalaCards based summary : Laryngostenosis, also known as stenosis of larynx, is related to diphtheria. An important gene associated with Laryngostenosis is FOXL2 (Forkhead Box L2). The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include trachea.

Related Diseases for Laryngostenosis

Diseases related to Laryngostenosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diphtheria 9.8

Comorbidity relations with Laryngostenosis via Phenotypic Disease Network (PDN):


Bronchitis Heart Disease
Hypertension, Essential Respiratory Failure

Symptoms & Phenotypes for Laryngostenosis

Drugs & Therapeutics for Laryngostenosis

Drugs for Laryngostenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
2
rituximab Approved Phase 3 174722-31-7 10201696
3 Alkylating Agents Phase 3,Not Applicable
4 Antineoplastic Agents, Alkylating Phase 3
5 Antineoplastic Agents, Immunological Phase 3
6 Immunosuppressive Agents Phase 3
7 Immunologic Factors Phase 3
8 Antirheumatic Agents Phase 3
9
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
10
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
11
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
12
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
13
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
14 Gastrointestinal Agents Phase 2
15 glucocorticoids Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Protective Agents Phase 2
18 Neuroprotective Agents Phase 2
19 Antiemetics Phase 2
20 Methylprednisolone Acetate Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22 Hormone Antagonists Phase 2
23 Hormones Phase 2
24 Autonomic Agents Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Prednisolone acetate Phase 2
28
Olaparib Approved Phase 1 763113-22-0 23725625
29 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
30
Temazepam Approved, Investigational Not Applicable 846-50-4 5391
31 Nucleic Acid Synthesis Inhibitors Not Applicable
32 Antibiotics, Antitubercular Not Applicable
33 Anti-Bacterial Agents Not Applicable
34 Mitomycins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid Not yet recruiting NCT03295383 Phase 3 Rituximab 1g IV;Cyclophosphamide 50Mg Oral Tablet;Placebo of Rituximab;Placebo Oral Tablet
2 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Active, not recruiting NCT03130374 Phase 1, Phase 2
3 Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management Not yet recruiting NCT03760354 Phase 2 Methylprednisolone
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Withdrawn NCT01977911 Phase 1, Phase 2
5 Olaparib and Radiotherapy in Head and Neck Cancer Recruiting NCT02229656 Phase 1 Olaparib
6 Study of Mitomycin-C Application in Laryngotracheal Stenosis Unknown status NCT01523275 Not Applicable Mitomycin -C
7 Functional Modeling of the Pediatric Airway Completed NCT01690078
8 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
9 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Active, not recruiting NCT02481817
10 Laryngeal Allograft Transplantation Enrolling by invitation NCT03269396 Not Applicable

Search NIH Clinical Center for Laryngostenosis

Cochrane evidence based reviews: laryngostenosis

Genetic Tests for Laryngostenosis

Anatomical Context for Laryngostenosis

MalaCards organs/tissues related to Laryngostenosis:

42
Trachea

Publications for Laryngostenosis

Articles related to Laryngostenosis:

# Title Authors Year
1
Severe feeding problems and congenital laryngostenosis in a patient with 3q23 deletion. ( 9266197 )
1997
2
Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13363239 )
1956
3
Mechanical appliance for cicatricial stenosis of larynx and upper part of trachea; report of case. ( 13422506 )
1956
4
Three cases of congenital laryngostenosis with different etiologies. ( 18885519 )
1948
5
Stenosis of Larynx due to Lupus, now being treated by Progressive Dilatation. ( 19988356 )
1931
6
OPERATIVE RELIEF OF LARYNGOSTENOSIS. ( 17865603 )
1927
7
Stenosis of Larynx. ( 19975933 )
1912
8
Complete Stenosis of Larynx left after Diphtheria and Tracheotomy, in a Boy when aged 1 year and 2 months; completely cured by Repeated Intubations spread over Three Years. ( 19974419 )
1910
9
Stenosis of Larynx in a Child. ( 19973689 )
1909

Variations for Laryngostenosis

Expression for Laryngostenosis

Search GEO for disease gene expression data for Laryngostenosis.

Pathways for Laryngostenosis

GO Terms for Laryngostenosis

Sources for Laryngostenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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