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MCID: LRY004
MIFTS: 33

Laryngotracheitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Laryngotracheitis

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MalaCards integrated aliases for Laryngotracheitis:

Name: Laryngotracheitis 12 15 70

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050148
ICD9CM 34 464 476.1
SNOMED-CT 67 276443001 83271005
ICD10 32 J04 J37.1
UMLS 70 C0023076 C0155811 C0155837
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Summaries for Laryngotracheitis

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Disease Ontology : 12 An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.

MalaCards based summary : Laryngotracheitis is related to newcastle disease and croup. An important gene associated with Laryngotracheitis is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are Lysosome and Malaria. The drugs Anesthetics and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include trachea, kidney and eye.

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Related Diseases for Laryngotracheitis

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Diseases related to Laryngotracheitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 newcastle disease 10.5
2 croup 10.5
3 bronchitis 10.5
4 conjunctivitis 10.4
5 tracheitis 10.4
6 upper respiratory tract disease 10.3
7 avian influenza 10.3
8 laryngitis 10.2
9 chickenpox 10.2
10 herpes simplex 10.2
11 skin hemangioma 10.1 FUCA2 FUCA1
12 mannosidosis, alpha b, lysosomal 10.1 FUCA2 FUCA1
13 reticuloendotheliosis, x-linked 10.1
14 epiglottitis 10.1
15 angiokeratoma 10.1 FUCA2 FUCA1
16 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 1 10.1 GYPC ACKR1
17 genital herpes 10.1 GYPC ACKR1
18 pharyngitis 10.0
19 plague 10.0
20 rhinitis 10.0
21 acute laryngitis 10.0
22 glycoproteinosis 10.0 GLB1 FUCA2
23 mucolipidosis iii alpha/beta 10.0 FUCA2 FUCA1
24 hereditary elliptocytosis 10.0 GYPC ACKR1
25 asthma 10.0
26 disease by infectious agent 10.0
27 tonsillitis 10.0
28 pre-eclampsia 10.0
29 asphyxia neonatorum 10.0
30 pertussis 10.0
31 diphtheria 10.0
32 48,xyyy 10.0
33 autoimmune gastrointestinal dysmotility 10.0
34 cytokine deficiency 10.0
35 chronic laryngitis 9.9
36 fucosidosis 9.9 GLB1 FUCA2 FUCA1
37 hurler syndrome 9.9 GLB1 FUCA2 FUCA1
38 scheie syndrome 9.9 GLB1 FUCA2 FUCA1
39 mucopolysaccharidosis-plus syndrome 9.9 GLB1 FUCA2 FUCA1
40 inclusion body myopathy with paget disease of bone and frontotemporal dementia 9.9 GYPC ACKR1
41 pfeiffer syndrome 9.8
42 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.8
43 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
44 cyanosis, transient neonatal 9.8
45 ifap syndrome 2 9.8
46 lymphoma 9.8
47 b-lymphoblastic leukemia/lymphoma 9.8
48 human cytomegalovirus infection 9.8
49 gastric ulcer 9.8
50 laryngostenosis 9.8

Graphical network of the top 20 diseases related to Laryngotracheitis:



Diseases related to Laryngotracheitis
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Symptoms & Phenotypes for Laryngotracheitis

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Drugs & Therapeutics for Laryngotracheitis

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Drugs for Laryngotracheitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics
2 Antibiotics, Antitubercular
3 Mitomycins
4 Alkylating Agents
5 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells Completed NCT03130374 Phase 1, Phase 2
2 Dynamic Laryngotracheal Separation for Aspiration. Prevention of Silent Aspiration Pneumonia During Swallowing by an Implanted Stimulator Suspended NCT00580346 Phase 1
3 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326
4 Thulium Contact Laser in the Treatment of Tumorous and Non-tumorous Laryngotracheal Stenosis Completed NCT02587546
5 Assessment of Primary Oxygenation and Airflow Measurement for Endoscopic Laryngeal Surgery Recruiting NCT03222869
6 Return of Aspiration-Free Swallow After Laryngotracheal Anesthesia (LTA) Recruiting NCT04575870
7 A Randomized Study of Mitomycin-C Application in the Endoscopic Surgical Treatment of Patients With Laryngotracheal Stenosis Terminated NCT01523275 Mitomycin -C

Search NIH Clinical Center for Laryngotracheitis

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Genetic Tests for Laryngotracheitis

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Anatomical Context for Laryngotracheitis

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MalaCards organs/tissues related to Laryngotracheitis:

40
Trachea, Kidney, Eye, Liver, Bone Marrow, Spleen, Cortex
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Publications for Laryngotracheitis

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Articles related to Laryngotracheitis:

(show top 50) (show all 881)
# Title Authors PMID Year
1
Research Note: Simultaneous detection of infectious laryngotracheitis virus, fowlpox virus, and reticuloendotheliosis virus in chicken specimens. 61
33647723 2021
2
Pathogenic and Transmission Potential of Wildtype and Chicken Embryo Origin (CEO) Vaccine Revertant Infectious Laryngotracheitis Virus. 61
33805117 2021
3
Recombinase-aided amplification-lateral flow dipstick assay-a specific and sensitive method for visual detection of avian infectious laryngotracheitis virus. 61
33518305 2021
4
Control, Elimination, and Monitoring of Infectious Laryngotracheitis in a Multiage Commercial Layer Pullet Farm in Canada. 61
33647967 2021
5
Metagenomic Analysis of the Respiratory Microbiome of a Broiler Flock from Hatching to Processing. 61
33807233 2021
6
Health surveillance of a potential bridge host: pathogen exposure risks posed to avian populations augmented with captive-bred pheasants. 61
33711203 2021
7
Two stage, nested isothermal amplification in a single tube. 61
33367323 2021
8
Indicators and risk factors of infectious laryngotracheitis in layer hen flocks in Algeria. 61
33642803 2021
9
Detection of infectious laryngotracheitis virus (ILTV) in tissues and blood fractions from experimentally infected chickens using PCR and immunostaining analyses. 61
33310555 2021
10
A Curious Case of Croup: Laryngotracheitis Caused by COVID-19. 61
32913132 2021
11
Marked differences in virulence of three Australian field isolates of infectious laryngotracheitis virus in meat and layer chickens. 61
32720515 2020
12
Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control - a comprehensive review. 61
32315579 2020
13
Genomic Stability for PCR Detection of Infectious Laryngotracheitis Virus and Infectious Bronchitis Virus in Poultry Dust Samples Stored Under Different Conditions. 61
33647150 2020
14
Application of recombinase polymerase amplification method for rapid detection of infectious laryngotracheitis virus. 61
32758643 2020
15
Assessment of A20 infectious laryngotracheitis vaccine take in meat chickens using swab and dust samples following mass vaccination in drinking water. 61
33176212 2020
16
Air sampling for detection of infectious laryngotracheitis (ILT) in commercial poultry flocks. 61
33298179 2020
17
Probiotics in the add-on treatment of laryngotracheitis: a clinical experience. 61
33426864 2020
18
Superinfection and recombination of infectious laryngotracheitis virus vaccines in the natural host. 61
33012604 2020
19
Analysis of Whole-Genome Sequences of Infectious laryngotracheitis Virus Isolates from Poultry Flocks in Canada: Evidence of Recombination. 61
33198373 2020
20
Seroprevalence of infectious laryngotracheitis disease in backyard chickens in villages of Ada'a district, Oromia, Ethiopia: first report. 61
32583205 2020
21
Molecular detection and genetic characterization of infectious laryngotracheitis virus in poultry in Myanmar. 61
33228640 2020
22
Probiotics for the management of upper respiratory diseases. 61
33426859 2020
23
Glycoprotein-C-gene-deleted recombinant infectious laryngotracheitis virus expressing a genotype VII Newcastle disease virus fusion protein protects against virulent infectious laryngotracheitis virus and Newcastle disease virus. 61
33011664 2020
24
Isolation, identification and chemical inactivation of infectious laryngotracheitis virus for use as a vaccine candidate. 61
33112636 2020
25
Research Note: Rapid detection of avian infectious laryngotracheitis virus with real-time fluorescence-based recombinase-aided amplification. 61
32988516 2020
26
Recombinant Fowlpox Virus Expressing gB Gene from Predominantly Epidemic Infectious Larygnotracheitis Virus Strain Demonstrates Better Immune Protection in SPF Chickens. 61
33105740 2020
27
Genotyping of Infectious Laryngotracheitis Virus (ILTV) Isolates from Western Canadian Provinces of Alberta and British Columbia Based on Partial Open Reading Frame (ORF) a and b. 61
32932922 2020
28
Optimization and application of a high-resolution melting protocol in the characterization of avian infectious laryngotracheitis virus. 61
32921516 2020
29
Infectious laryngotracheitis: an update on current approaches for prevention of an old disease. 61
32810247 2020
30
Ocular exposure to infectious laryngotracheitis virus alters leukocyte subsets in the head-associated lymphoid tissues and trachea of 6-week-old White Leghorn chickens. 61
32301627 2020
31
Latency characteristics in specific pathogen-free chickens 21 and 35 days after intra-tracheal inoculation with vaccine or field strains of infectious laryngotracheitis virus. 61
32352307 2020
32
Establishment of a Simple and Efficient Reverse Genetics System for Canine Adenoviruses Using Bacterial Artificial Chromosomes. 61
32708703 2020
33
Development of indirect ELISA for the detection of canine adenovirus type 2 antibodies in dog sera. 61
32735100 2020
34
Development and application of a colloidal gold test strip for the rapid detection of the infectious laryngotracheitis virus. 61
32359575 2020
35
Pathogenesis and tissue tropism of natural field recombinants of infectious laryngotracheitis virus. 61
32273014 2020
36
A modified loop-mediated isothermal amplification method for detecting avian infectious laryngotracheitis virus. 61
32324091 2020
37
Full genomic characterisation of an emerging infectious laryngotracheitis virus class 7b from Australia linked to a vaccine strain revealed its identity. 61
31678646 2020
38
Molecular characterization and genetic diversity of the infectious laryngotracheitis virus strains circulating in Egypt during the outbreaks of 2018 and 2019. 61
31938839 2020
39
Development and application of a combined molecular and tissue culture-based approach to detect latent infectious laryngotracheitis virus (ILTV) in chickens. 61
31821819 2020
40
A practical method for assessing infectious laryngotracheitis vaccine take in broilers following mass administration in water: Spatial and temporal variation in viral genome content of poultry dust after vaccination. 61
31928697 2020
41
Retraction for Kanabagatte Basavarajappa et al., "Glycoprotein-Based Enzyme-Linked Immunosorbent Assays for Serodiagnosis of Infectious Laryngotracheitis". 61
32094121 2020
42
Genetic stability of a Newcastle disease virus vectored infectious laryngotracheitis virus vaccine after serial passages in chicken embryos. 61
31703935 2020
43
Genomic recombination between infectious laryngotracheitis vaccine strains occurs under a broad range of infection conditions in vitro and in ovo. 61
32119681 2020
44
Methods to prevent PCR amplification of DNA from non-viable virus were not successful for infectious laryngotracheitis virus. 61
32442180 2020
45
Health status of free-ranging ring-necked pheasant chicks (Phasianus colchicus) in North-Western Germany. 61
32544211 2020
46
A Melanin bleaching method to prevent non-specific immunostaining of chicken feathers. 61
32612940 2020
47
[The effectiveness of local therapy of acute inflammatory diseases of the upper respiratory tract]. 61
32241993 2020
48
Inhibitory Activity of Illicium verum Extracts against Avian Viruses. 61
32411246 2020
49
Appearance and management of COVID-19 laryngo-tracheitis: two case reports. 61
32724561 2020
50
Multilocus analysis of Gallid herpesvirus 1 in layer chickens in Iraq. 61
32158168 2020
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Variations for Laryngotracheitis

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Expression for Laryngotracheitis

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Search GEO for disease gene expression data for Laryngotracheitis.
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Pathways for Laryngotracheitis

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Pathways related to Laryngotracheitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 36
11.24 GLB1 FUCA2 FUCA1
2
Malaria 36
10.85 GYPC ACKR1
3
Other glycan degradation 36
10.05 GLB1 FUCA2 FUCA1
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GO Terms for Laryngotracheitis

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Cellular components related to Laryngotracheitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.8 GLB1 FUCA2 FUCA1

Biological processes related to Laryngotracheitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.5 GLB1 FUCA2 FUCA1
2 metabolic process GO:0008152 9.43 GLB1 FUCA2 FUCA1
3 glycosaminoglycan catabolic process GO:0006027 9.16 GLB1 FUCA1
4 fucose metabolic process GO:0006004 8.96 FUCA2 FUCA1
5 glycoside catabolic process GO:0016139 8.62 FUCA2 FUCA1

Molecular functions related to Laryngotracheitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.13 GLB1 FUCA2 FUCA1
2 alpha-L-fucosidase activity GO:0004560 8.62 FUCA2 FUCA1
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Sources for Laryngotracheitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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