MCID: LRY004
MIFTS: 29

Laryngotracheitis

Categories: Respiratory diseases

Aliases & Classifications for Laryngotracheitis

Summaries for Laryngotracheitis

Disease Ontology : 12 An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.

MalaCards based summary : Laryngotracheitis is related to laryngotracheal angioma and myhre syndrome. An important gene associated with Laryngotracheitis is STAG2 (Stromal Antigen 2), and among its related pathways/superpathways is Malaria. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include trachea, kidney and testes.

Related Diseases for Laryngotracheitis

Diseases related to Laryngotracheitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 laryngotracheal angioma 12.2
2 myhre syndrome 11.4
3 laryngeal cleft 11.1
4 newcastle disease 10.3
5 bronchitis 10.3
6 croup 10.3
7 relapsing polychondritis 10.2
8 viral infectious disease 10.2
9 influenza 10.1
10 herpes simplex 10.1
11 chronic laryngitis 10.1
12 avian influenza 10.1
13 pneumonia 10.1
14 hemangioma 10.0
15 aspiration pneumonia 10.0
16 papilloma 10.0
17 tracheal stenosis 10.0
18 epiglottitis 10.0
19 digeorge syndrome 9.9
20 granulomatosis with polyangiitis 9.9
21 tracheomalacia 9.9
22 pharyngitis 9.9
23 rhinitis 9.9
24 amyloidosis 9.9
25 dysphagia 9.9
26 necrotizing gastritis 9.8 ACKR1 GYPC
27 emphysema, congenital lobar 9.8
28 spondyloepiphyseal dysplasia with congenital joint dislocations 9.8
29 thoracolaryngopelvic dysplasia 9.8
30 thyroid cancer, nonmedullary, 1 9.8
31 tracheoesophageal fistula with or without esophageal atresia 9.8
32 chondrosarcoma 9.8
33 acute insulin response 9.8
34 nasopharyngeal carcinoma 9.8
35 hypertrophic scars 9.8
36 pulmonary hypertension 9.8
37 craniosynostosis 9.8
38 keloids 9.8
39 motor neuron disease 9.8
40 withdrawal disorder 9.8
41 esophageal atresia 9.8
42 pertussis 9.8
43 rhinoscleroma 9.8
44 esophagitis 9.8
45 quadriplegia 9.8
46 toxic shock syndrome 9.8
47 squamous cell carcinoma 9.8
48 thyroid cancer 9.8
49 rhinosporidiosis 9.8
50 granular cell tumor 9.8

Graphical network of the top 20 diseases related to Laryngotracheitis:



Diseases related to Laryngotracheitis

Symptoms & Phenotypes for Laryngotracheitis

Drugs & Therapeutics for Laryngotracheitis

Drugs for Laryngotracheitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Fluticasone Approved, Experimental Phase 4,Phase 3 90566-53-3 62924
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 68602 5311068
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
10 Hormones Phase 4,Phase 3,Phase 2
11 BB 1101 Phase 4,Phase 2
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
13 HIV Protease Inhibitors Phase 4,Phase 2
14 Antiemetics Phase 4,Phase 3,Phase 2
15 Hormone Antagonists Phase 4,Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17
protease inhibitors Phase 4,Phase 2
18 glucocorticoids Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 Autonomic Agents Phase 4,Phase 3,Phase 2
21 Sympathomimetics Phase 4
22 Respiratory System Agents Phase 4,Phase 3
23 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
24 Adrenergic beta-Agonists Phase 4
25
Salmeterol xinafoate Phase 4 94749-08-3 56801
26 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
27 Bronchodilator Agents Phase 4,Phase 3
28 Anti-Allergic Agents Phase 4,Phase 3
29 Adrenergic Agents Phase 4,Phase 3
30 Adrenergic Agonists Phase 4,Phase 3
31 Adrenergic beta-2 Receptor Agonists Phase 4
32 Anti-Asthmatic Agents Phase 4,Phase 3
33 Dermatologic Agents Phase 4,Phase 3
34 Vasoconstrictor Agents Phase 4
35 Mydriatics Phase 4
36 Epinephryl borate Phase 4
37 Adrenergic alpha-Agonists Phase 4,Phase 3
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
39 Analgesics, Non-Narcotic Phase 4,Phase 3
40 Analgesics Phase 4,Phase 3
41 Central Nervous System Depressants Phase 4,Phase 3
42 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
43 Hypnotics and Sedatives Phase 4,Phase 3
44
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
45
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
46
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
47
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
48
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
49
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
50
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
2 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4 Salmeterol/fluticasone propionate and fluticasone propionate
3 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
4 Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Recruiting NCT03705273 Phase 4 Dexamethasone IV for PO;Dexamethasone crushed tablets
5 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
6 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
7 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Completed NCT01218308 Phase 3
8 Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy Recruiting NCT03211871 Phase 3 Dexmedetomidine;Normal Saline Flush, 0.9% Injectable Solution_#1
9 Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART) Active, not recruiting NCT00920621 Phase 3
10 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
11 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
12 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
13 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
14 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children Completed NCT00767416 Phase 1, Phase 2
15 Phase IIb Study Evaluating Immunogenic Chemotherapy Combined With Ipilimumab and Nivolumab in Breast Cancer Recruiting NCT03409198 Phase 2 Ipilimumab;Nivolumab;Pegylated liposomal doxorubicin;Cyclophosphamide
16 Aprepitant Triple Therapy Caused Chemotherapy Induced Nausea And Vomiting In Gastrointestinal Tumors Recruiting NCT03674294 Phase 2 Aprepitant;Palonosetron;Dexamethasone;Placebo Oral Tablet
17 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Active, not recruiting NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
18 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
19 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
20 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
21 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Unknown status NCT02517294 Not Applicable
22 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Completed NCT03392363
23 Diagnosing Respiratory Disease in Children Using Cough Sounds Completed NCT02973282
24 A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children Completed NCT00626808 No Intervention
25 Re-evaluation of Blind Intubation Through the Air-Q Intubating Laryngeal Airway Completed NCT03778762 Not Applicable
26 Supplement to Hospital to Home Outcomes Completed NCT03224130 Not Applicable
27 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240 Not Applicable
28 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849 Not Applicable

Search NIH Clinical Center for Laryngotracheitis

Genetic Tests for Laryngotracheitis

Anatomical Context for Laryngotracheitis

MalaCards organs/tissues related to Laryngotracheitis:

41
Trachea, Kidney, Testes, Eye, Lung, Spleen, Thyroid

Publications for Laryngotracheitis

Articles related to Laryngotracheitis:

(show top 50) (show all 469)
# Title Authors Year
1
A double recombinant herpes virus of turkeys for the protection of chickens against Newcastle, infectious laryngotracheitis and Marek's diseases. ( 30404540 )
2019
2
Development of a qPCR for the detection of infectious laryngotracheitis virus (ILTV) based on the gE gene. ( 29798683 )
2018
3
Cytokine genes transcription in trachea, Harderian gland, and trigeminal ganglia of chickens inoculated with virulent infectious laryngotracheitis virus (ILTV) strain. ( 29963906 )
2018
4
Full-Genome Sequence of Infectious Laryngotracheitis Virus (Gallid Alphaherpesvirus 1) Strain VFAR-043, Isolated in Peru. ( 29519822 )
2018
5
Infectious Laryngotracheitis Virus Viral Chemokine-Binding Protein Glycoprotein G Alters Transcription of Key Inflammatory Mediators<i>In Vitro</i>and<i>In Vivo</i>. ( 29070686 )
2018
6
Occurrence of Infectious laryngotracheitis outbreaks in commercial layer hens detected by ELISA. ( 29424631 )
2018
7
Attenuation and Protection Efficacy of a Recombinant Infectious Laryngotracheitis Virus (ILTV) Depleted of Open Reading Frame C (I9ORFC) when Delivered in ovo. ( 29944395 )
2018
8
Analysis of codon usage pattern of infectious laryngotracheitis virus immunogenic glycoproteins and its biological implications. ( 29654923 )
2018
9
In ovo CpG DNA delivery increases innate and adaptive immune cells in respiratory, gastrointestinal and immune systems post-hatch correlating with lower infectious laryngotracheitis virus infection. ( 29513732 )
2018
10
Development of a sensitive and specific xMAP assay for detection of antibodies against infectious laryngotracheitis and bronchitis viruses. ( 30241540 )
2018
11
The therapeutic effect of Yinhuangerchen mixture on Avian infectious laryngotracheitis. ( 29897576 )
2018
12
Establishment and application of real-time fluorescence-based quantitative PCR for detection of infectious laryngotracheitis virus using SYBR Green I. ( 30053171 )
2018
13
Replication-independent reduction in the number and diversity of recombinant progeny viruses in chickens vaccinated with an attenuated infectious laryngotracheitis vaccine. ( 30104116 )
2018
14
Identification and management of cough-induced laryngotracheitis. ( 30123340 )
2018
15
Pyogranulomatous obliterative laryngotracheitis by Rhizopus arrhizus (syn. R. oryzae) in a free-ranging Atlantic spotted dolphin Stenella frontalis. ( 30198490 )
2018
16
Single Nucleotide Polymorphism Genotyping Analysis Shows That Vaccination Can Limit the Number and Diversity of Recombinant Progeny of Infectious Laryngotracheitis Viruses from the United States. ( 30242009 )
2018
17
Detection of infectious laryngotracheitis virus (Gallid herpesvirus-1) from clinically infected chickens in Egypt by different diagnostic methods. ( 30349566 )
2018
18
Development and application of high-resolution melting analysis for the classification of infectious laryngotracheitis virus strains and detection of recombinant progeny. ( 30421085 )
2018
19
Recombinant infectious laryngotracheitis virus expressing Newcastle disease virus F protein protects chickens against infectious laryngotracheitis virus and Newcastle disease virus challenge. ( 30448332 )
2018
20
Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens. ( 30521554 )
2018
21
Molecular Characterization and Cluster Analysis of Field Isolates of Avian Infectious Laryngotracheitis Virus from Argentina. ( 29326949 )
2017
22
The route of inoculation dictates the replication patterns of the infectious laryngotracheitis virus (ILTV) pathogenic strain and chicken embryo origin (CEO) vaccine. ( 28532159 )
2017
23
Development and application of a TaqMan single nucleotide polymorphism genotyping assay to study infectious laryngotracheitis virus recombination in the natural host. ( 28350819 )
2017
24
Presence of DNA extracellular traps but not MUC5AC and MUC5B mucin in mucoid plugs/casts of infectious laryngotracheitis virus (ILTV) infected tracheas of chickens. ( 27756631 )
2017
25
Impairment of infectious laryngotracheitis virus replication by deletion of the UL[-1] gene. ( 28194527 )
2017
26
Newcastle disease virus vectored infectious laryngotracheitis vaccines protect commercial broiler chickens in the presence of maternally derived antibodies. ( 28052812 )
2017
27
Esophagitis and Pharyngitis Associated with Avian Infectious Laryngotracheitis in Backyard Chickens: Two Cases. ( 28665721 )
2017
28
Genetic diversity of infectious laryngotracheitis virus during in vivo co-infection parallels viral replication and arises from recombination 'hot-spots' within the genome. ( 28939604 )
2017
29
Spread of the newly emerging infectious laryngotracheitis viruses in Australia. ( 27223632 )
2016
30
Full Genome Sequence-Based Comparative Study of Wild-Type and Vaccine Strains of Infectious Laryngotracheitis Virus from Italy. ( 26890525 )
2016
31
Early infection with Marek's disease virus can jeopardize protection conferred by laryngotracheitis vaccines: a method to study MDV-induced immunosuppression. ( 27207594 )
2016
32
Evaluation of the transcriptional status of host cytokines and viral genes in the trachea of vaccinated and non-vaccinated chickens after challenge with the infectious laryngotracheitis virus. ( 26926298 )
2016
33
Current and future vaccines and vaccination strategies against infectious laryngotracheitis (ILT) respiratory disease of poultry. ( 28057380 )
2016
34
Attenuation and protection efficacy of open reading frame C (ORF C) gene deleted recombinant of infectious laryngotracheitis virus (ILTV). ( 27283114 )
2016
35
Generation of Newcastle Disease Virus (NDV) Recombinants Expressing the Infectious Laryngotracheitis Virus (ILTV) Glycoprotein gB or gD as Dual Vaccines. ( 27076292 )
2016
36
Infectious laryngotracheitis virus (ILTV) vaccine intake evaluation by detection of virus amplification in feather pulps of vaccinated chickens. ( 26784685 )
2016
37
Sero-epizootiological investigation of infectious laryngotracheitis infection in commercial poultry of Plateau State, north central Nigeria. ( 26918306 )
2016
38
Characterization of field strains of infectious laryngotracheitis virus in China by restriction fragment length polymorphism and sequence analysis. ( 26699520 )
2016
39
Avian infectious laryngotracheitis: A neglected poultry health threat in India. ( 27423384 )
2016
40
Genotyping of infectious laryngotracheitis virus using allelic variations from multiple genomic regions. ( 26956802 )
2016
41
Comparison of the pathogenicity of the USDA challenge virus strain to a field strain of infectious laryngotracheitis virus. ( 26050912 )
2015
42
In ovo delivery of toll-like receptor 2 ligand, lipoteichoic acid induces pro-inflammatory mediators reducing post-hatch infectious laryngotracheitis virus infection. ( 25764942 )
2015
43
Persistence of the tissue culture origin vaccine for infectious laryngotracheitis virus in commercial chicken flocks in Brazil. ( 26500264 )
2015
44
In ovo delivery of CpG DNA reduces avian infectious laryngotracheitis virus induced mortality and morbidity. ( 25856635 )
2015
45
Infection of Broilers with Two Virulent Strains of Infectious Laryngotracheitis Virus: Criteria for Evaluation of Experimental Infections. ( 26478158 )
2015
46
Development and Validation of TaqMan Real-Time Polymerase Chain Reaction Assays for the Quantitative and Differential Detection of Wild-Type Infectious Laryngotracheitis Viruses from a Glycoprotein G-Deficient Candidate Vaccine Strain. ( 26292527 )
2015
47
Evaluation of the Protection Efficacy of a Serotype 1 Marek's Disease Virus-Vectored Bivalent Vaccine Against Infectious Laryngotracheitis and Marek's Disease. ( 26473676 )
2015
48
Growth kinetics and transmission potential of existing and emerging field strains of infectious laryngotracheitis virus. ( 25785629 )
2015
49
Real-time PCR quantification of infectious laryngotracheitis virus in chicken tissues, faeces, isolator-dust and bedding material over 28 days following infection reveals high levels in faeces and dust. ( 26294959 )
2015
50
Genome-wide gene expression analysis identifies the proto-oncogene tyrosine-protein kinase Src as a crucial virulence determinant of the infectious laryngotracheitis virus in chicken cells. ( 26446601 )
2015

Variations for Laryngotracheitis

Expression for Laryngotracheitis

Search GEO for disease gene expression data for Laryngotracheitis.

Pathways for Laryngotracheitis

Pathways related to Laryngotracheitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.31 ACKR1 GYPC

GO Terms for Laryngotracheitis

Sources for Laryngotracheitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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