Larynx Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Larynx Sarcoma

MalaCards integrated aliases for Larynx Sarcoma:

Name: Larynx Sarcoma ¹¹ ¹⁴

Sarcoma of Larynx ¹¹

Laryngeal Sarcoma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:2877

NCIt ⁴⁹ C6020

UMLS ⁷¹ C1334377

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Summaries for Larynx Sarcoma

Disease Ontology: ¹¹ A larynx cancer that has material basis in abnormally proliferating cells derives from embryonic mesoderm.

MalaCards based summary: Larynx Sarcoma, also known as sarcoma of larynx, is related to larynx leiomyosarcoma and sarcoma. An important gene associated with Larynx Sarcoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Adhesion. Related phenotype is digestive/alimentary.

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Related Diseases for Larynx Sarcoma

Diseases related to Larynx Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Related Disease	Score	Top Affiliating Genes
1	larynx leiomyosarcoma	11.1
2	sarcoma	10.2
3	larynx cancer	10.1
4	ureter adenocarcinoma	10.0	NKX2-1 CEACAM5
5	aortic malignant tumor	10.0	NKX2-1 CEACAM5
6	ovarian cystic teratoma	10.0	NKX2-1 CEACAM5
7	cystic teratoma	10.0	NKX2-1 CEACAM5
8	teratoma	10.0	NKX2-1 CEACAM5
9	lymphohistiocytoid mesothelioma	10.0	NKX2-1 CEACAM5
10	ovarian germ cell teratoma	10.0	NKX2-1 CEACAM5
11	nasal cavity olfactory neuroblastoma	10.0	NKX2-1 CEACAM5
12	lymphangitis	10.0	NKX2-1 CEACAM5
13	pleomorphic carcinoma	10.0	NKX2-1 CEACAM5
14	papillary adenoma	10.0	NKX2-1 CEACAM5
15	thyroid dyshormonogenesis 2a	10.0	NKX2-1 CEACAM5
16	retinal melanoma	9.9	NKX2-1 CEACAM5
17	trachea carcinoma	9.9	NKX2-1 CEACAM5
18	mediastinal cancer	9.9	NKX2-1 CEACAM5
19	keratinizing squamous cell carcinoma	9.9	NKX2-1 CEACAM5
20	ovarian germ cell cancer	9.9	NKX2-1 CEACAM5
21	adenocarcinoma in situ	9.9	NKX2-1 CEACAM5
22	benign mesothelioma	9.9	NKX2-1 CEACAM5
23	mucinous adenocarcinoma	9.9	NKX2-1 CEACAM5
24	thyroid gland medullary carcinoma	9.9	NKX2-1 CEACAM5
25	sex cord-gonadal stromal tumor	9.9	NKX2-1 CEACAM5
26	bronchiolo-alveolar adenocarcinoma	9.9	NKX2-1 CEACAM5
27	papillary adenocarcinoma	9.9	NKX2-1 CEACAM5
28	leukemia, acute myeloid	9.9
29	ewing sarcoma	9.9
30	myxofibrosarcoma	9.9
31	adult respiratory distress syndrome	9.9
32	supraglottis cancer	9.9
33	spindle cell sarcoma	9.9
34	carcinosarcoma	9.9
35	myeloid sarcoma	9.9
36	acute myeloid leukemia with recurrent genetic anomaly	9.9
37	soft tissue sarcoma	9.9
38	benign teratoma	9.9	NKX2-1 CEACAM5
39	small cell carcinoma	9.9	NKX2-1 CEACAM5
40	adenosquamous carcinoma	9.9	NKX2-1 CEACAM5
41	thyroid carcinoma, familial medullary	9.9	NKX2-1 CEACAM5
42	salivary gland carcinoma	9.9	NKX2-1 CEACAM5
43	large cell carcinoma	9.9	NKX2-1 CEACAM5
44	rectum signet ring adenocarcinoma	9.9	EPCAM CEACAM5
45	vulva basal cell carcinoma	9.9	EPCAM CEACAM5
46	small cell cancer of the lung	9.9	NKX2-1 CEACAM5
47	cholangiolocellular carcinoma	9.9	EPCAM CEACAM5
48	squamous papillomatosis	9.9	EPCAM CEACAM5
49	thyroid gland disease	9.9	NKX2-1 CEACAM5
50	benign peritoneal mesothelioma	9.8	EPCAM CEACAM5

Graphical network of the top 20 diseases related to Larynx Sarcoma:

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Symptoms & Phenotypes for Larynx Sarcoma

MGI Mouse Phenotypes related to Larynx Sarcoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.8	CEACAM5 EPCAM NKX2-1

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Drugs & Therapeutics for Larynx Sarcoma

Search Clinical Trials, NIH Clinical Center for Larynx Sarcoma

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Genetic Tests for Larynx Sarcoma

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Anatomical Context for Larynx Sarcoma

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Publications for Larynx Sarcoma

Articles related to Larynx Sarcoma:

#	Title	Authors	PMID	Year
1	Ewing Sarcoma of Larynx: A Rare Case in a 5-Year-Old Boy. ⁶²	Pasha HA...Din NU	32313899	2020
2	[Soft tissue sarcoma of larynx: a case report]. ⁶²	Cai YX...Huang JZ	29871078	2016
3	Primary granulocytic sarcoma of larynx. ⁶²	Kim LY...Newman JG	24953995	2015
4	Synovial sarcomna of larynx-a rare site. ⁶²	Sridhar Reddy D...Lenin A	23120386	2007
5	Spindle cell sarcoma of larynx. ⁶²	Samdhani S...Srivastava SP	23120325	2006
6	[Sarcoma neurogenes of the larynx]. ⁶²	Szmeja Z...Majewski P	9591428	1998
7	[Rare tumors of the larynx]. ⁶²	Malec M	9454199	1995
8	Multiple primary tumors in patients with head and neck cancer. ⁶²	Miyahara H...Sato T	3836649	1985
9	Sarcoma of larynx; report of two cases. ⁶²	DIEGL KL	13007253	1953

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Genes for Larynx Sarcoma

Genes related to Larynx Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NKX2-1	NK2 Homeobox 1	Protein Coding	4.43	DISEASES inferred ¹⁴
2	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	3.96	DISEASES inferred ¹⁴
3	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	3.65	DISEASES inferred ¹⁴

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Variations for Larynx Sarcoma

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Expression for Larynx Sarcoma

Search GEO for disease gene expression data for Larynx Sarcoma.

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Pathways for Larynx Sarcoma

Pathways related to Larynx Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	11.19	EPCAM CEACAM5
2	Adhesion ³	10.71	EPCAM CEACAM5

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GO Terms for Larynx Sarcoma

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Sources for Larynx Sarcoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRY020 MIFTS: 18	Larynx Sarcoma Categories: Cancer diseases, Oral diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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