MCID: LRY020
MIFTS: 18

Larynx Sarcoma

Categories: Cancer diseases, Oral diseases, Respiratory diseases
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Aliases & Classifications for Larynx Sarcoma

MalaCards integrated aliases for Larynx Sarcoma:

Name: Larynx Sarcoma 11 14
Sarcoma of Larynx 11
Laryngeal Sarcoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:2877
NCIt 49 C6020
UMLS 71 C1334377

Summaries for Larynx Sarcoma

Disease Ontology: 11 A larynx cancer that has material basis in abnormally proliferating cells derives from embryonic mesoderm.

MalaCards based summary: Larynx Sarcoma, also known as sarcoma of larynx, is related to larynx leiomyosarcoma and sarcoma. An important gene associated with Larynx Sarcoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Adhesion. Related phenotype is digestive/alimentary.

Related Diseases for Larynx Sarcoma

Diseases related to Larynx Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 larynx leiomyosarcoma 11.1
2 sarcoma 10.2
3 larynx cancer 10.1
4 ureter adenocarcinoma 10.0 NKX2-1 CEACAM5
5 aortic malignant tumor 10.0 NKX2-1 CEACAM5
6 ovarian cystic teratoma 10.0 NKX2-1 CEACAM5
7 cystic teratoma 10.0 NKX2-1 CEACAM5
8 teratoma 10.0 NKX2-1 CEACAM5
9 lymphohistiocytoid mesothelioma 10.0 NKX2-1 CEACAM5
10 ovarian germ cell teratoma 10.0 NKX2-1 CEACAM5
11 nasal cavity olfactory neuroblastoma 10.0 NKX2-1 CEACAM5
12 lymphangitis 10.0 NKX2-1 CEACAM5
13 pleomorphic carcinoma 10.0 NKX2-1 CEACAM5
14 papillary adenoma 10.0 NKX2-1 CEACAM5
15 thyroid dyshormonogenesis 2a 10.0 NKX2-1 CEACAM5
16 retinal melanoma 9.9 NKX2-1 CEACAM5
17 trachea carcinoma 9.9 NKX2-1 CEACAM5
18 mediastinal cancer 9.9 NKX2-1 CEACAM5
19 keratinizing squamous cell carcinoma 9.9 NKX2-1 CEACAM5
20 ovarian germ cell cancer 9.9 NKX2-1 CEACAM5
21 adenocarcinoma in situ 9.9 NKX2-1 CEACAM5
22 benign mesothelioma 9.9 NKX2-1 CEACAM5
23 mucinous adenocarcinoma 9.9 NKX2-1 CEACAM5
24 thyroid gland medullary carcinoma 9.9 NKX2-1 CEACAM5
25 sex cord-gonadal stromal tumor 9.9 NKX2-1 CEACAM5
26 bronchiolo-alveolar adenocarcinoma 9.9 NKX2-1 CEACAM5
27 papillary adenocarcinoma 9.9 NKX2-1 CEACAM5
28 leukemia, acute myeloid 9.9
29 ewing sarcoma 9.9
30 myxofibrosarcoma 9.9
31 adult respiratory distress syndrome 9.9
32 supraglottis cancer 9.9
33 spindle cell sarcoma 9.9
34 carcinosarcoma 9.9
35 myeloid sarcoma 9.9
36 acute myeloid leukemia with recurrent genetic anomaly 9.9
37 soft tissue sarcoma 9.9
38 benign teratoma 9.9 NKX2-1 CEACAM5
39 small cell carcinoma 9.9 NKX2-1 CEACAM5
40 adenosquamous carcinoma 9.9 NKX2-1 CEACAM5
41 thyroid carcinoma, familial medullary 9.9 NKX2-1 CEACAM5
42 salivary gland carcinoma 9.9 NKX2-1 CEACAM5
43 large cell carcinoma 9.9 NKX2-1 CEACAM5
44 rectum signet ring adenocarcinoma 9.9 EPCAM CEACAM5
45 vulva basal cell carcinoma 9.9 EPCAM CEACAM5
46 small cell cancer of the lung 9.9 NKX2-1 CEACAM5
47 cholangiolocellular carcinoma 9.9 EPCAM CEACAM5
48 squamous papillomatosis 9.9 EPCAM CEACAM5
49 thyroid gland disease 9.9 NKX2-1 CEACAM5
50 benign peritoneal mesothelioma 9.8 EPCAM CEACAM5

Graphical network of the top 20 diseases related to Larynx Sarcoma:



Diseases related to Larynx Sarcoma

Symptoms & Phenotypes for Larynx Sarcoma

MGI Mouse Phenotypes related to Larynx Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 CEACAM5 EPCAM NKX2-1

Drugs & Therapeutics for Larynx Sarcoma

Search Clinical Trials, NIH Clinical Center for Larynx Sarcoma

Genetic Tests for Larynx Sarcoma

Anatomical Context for Larynx Sarcoma

Publications for Larynx Sarcoma

Articles related to Larynx Sarcoma:

# Title Authors PMID Year
1
Ewing Sarcoma of Larynx: A Rare Case in a 5-Year-Old Boy. 62
32313899 2020
2
[Soft tissue sarcoma of larynx: a case report]. 62
29871078 2016
3
Primary granulocytic sarcoma of larynx. 62
24953995 2015
4
Synovial sarcomna of larynx-a rare site. 62
23120386 2007
5
Spindle cell sarcoma of larynx. 62
23120325 2006
6
[Sarcoma neurogenes of the larynx]. 62
9591428 1998
7
[Rare tumors of the larynx]. 62
9454199 1995
8
Multiple primary tumors in patients with head and neck cancer. 62
3836649 1985
9
Sarcoma of larynx; report of two cases. 62
13007253 1953

Variations for Larynx Sarcoma

Expression for Larynx Sarcoma

Search GEO for disease gene expression data for Larynx Sarcoma.

Pathways for Larynx Sarcoma

Pathways related to Larynx Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 EPCAM CEACAM5
2 10.71 EPCAM CEACAM5

GO Terms for Larynx Sarcoma

Sources for Larynx Sarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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