Larynx Squamous Papilloma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Larynx Squamous Papilloma

MalaCards integrated aliases for Larynx Squamous Papilloma:

Name: Larynx Squamous Papilloma ¹¹ ¹⁴

Laryngeal Squamous Cell Papilloma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:10071

NCIt ⁴⁹ C7742

SNOMED-CT ⁶⁸ 269637007

UMLS ⁷¹ C0240164

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Summaries for Larynx Squamous Papilloma

Disease Ontology: ¹¹ A laryngeal benign neoplasm that is characterized by the presence of a connective tissue core covered by stratified squamous epithelium and that has symptom hoarseness.

MalaCards based summary: Larynx Squamous Papilloma, also known as laryngeal squamous cell papilloma, is related to squamous cell papilloma and oral hairy leukoplakia, and has symptoms including hoarseness An important gene associated with Larynx Squamous Papilloma is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Disease and Class I MHC mediated antigen processing and presentation.

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Related Diseases for Larynx Squamous Papilloma

Diseases related to Larynx Squamous Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)

#	Related Disease	Score	Top Affiliating Genes
1	squamous cell papilloma	29.9	TP53 HRAS CDKN2A
2	oral hairy leukoplakia	10.2	PSMB9 PDLIM7
3	trachea carcinoma in situ	10.2	HRAS CDKN2A
4	pancreatoblastoma	10.1	HRAS CDKN2A
5	urethra transitional cell carcinoma	10.1	TP53 HBZ
6	acral lentiginous melanoma	10.1	HRAS CDKN2A
7	b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	10.1	TP53 CDKN2A
8	spitzoid melanoma	10.1	HRAS CDKN2A
9	endometrial squamous cell carcinoma	10.1	TP53 CDKN2A
10	esophagus verrucous carcinoma	10.1	TP53 CDKN2A
11	verrucous carcinoma	10.1	TP53 CDKN2A
12	penile benign neoplasm	10.1	TP53 CDKN2A
13	suppressor of tumorigenicity 3	10.1	TP53 CDKN2A
14	infiltrating angiolipoma	10.1	HRAS CDKN2A
15	conjunctival squamous cell carcinoma	10.1	TP53 CDKN2A
16	papilloma	10.1
17	bladder clear cell adenocarcinoma	10.1	TP53 CDKN2A
18	atypical neurofibroma	10.1	TP53 CDKN2A
19	lip cancer	10.1	TP53 CDKN2A
20	male urethral cancer	10.1	TP53 CDKN2A
21	chronic cervicitis	10.1	TP53 CDKN2A
22	basaloid squamous cell carcinoma	10.1	TP53 CDKN2A
23	anal squamous cell carcinoma	10.1	TP53 CDKN2A
24	male reproductive organ benign neoplasm	10.1	TP53 CDKN2A
25	paranasal sinus cancer	10.0	TP53 CDKN2A
26	idh-wildtype glioblastoma	10.0	TP53 CDKN2A
27	bone squamous cell carcinoma	10.0	TP53 CDKN2A
28	pleomorphic xanthoastrocytoma	10.0	TP53 CDKN2A
29	borst-jadassohn intraepidermal carcinoma	10.0	TP53 CDKN2A
30	mixed glioma	10.0	TP53 CDKN2A
31	phimosis	10.0	TP53 CDKN2A
32	uterus carcinoma in situ	10.0	TP53 CDKN2A
33	barrett's adenocarcinoma	10.0	TP53 CDKN2A
34	neurofibrosarcoma	10.0	TP53 CDKN2A
35	vaginal carcinosarcoma	10.0	TP53 HRAS
36	acanthoma	10.0	TP53 CDKN2A
37	liver angiosarcoma	10.0	TP53 HRAS
38	cystadenofibroma	10.0	TP53 HRAS
39	cervix uteri carcinoma in situ	10.0	TP53 CDKN2A
40	endosalpingiosis	10.0	TP53 HRAS
41	bladder transitional cell papilloma	10.0	TP53 HRAS
42	appendix adenocarcinoma	10.0	TP53 HRAS
43	inverted papilloma	10.0	TP53 SRCIN1 CDKN2A
44	lymphoepithelioma-like carcinoma	10.0	TP53 PDLIM7 CDKN2A
45	large cell carcinoma with rhabdoid phenotype	10.0	TP53 HRAS
46	pancreatic signet ring cell adenocarcinoma	10.0	TP53 HRAS
47	biliary tract benign neoplasm	10.0	TP53 HRAS
48	pleomorphic carcinoma	10.0	TP53 HRAS
49	small intestine adenocarcinoma	10.0	TP53 HRAS
50	papillary adenoma	10.0	TP53 HRAS

Graphical network of the top 20 diseases related to Larynx Squamous Papilloma:

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Symptoms & Phenotypes for Larynx Squamous Papilloma

Symptoms:

¹¹

• hoarseness

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Drugs & Therapeutics for Larynx Squamous Papilloma

Search Clinical Trials, NIH Clinical Center for Larynx Squamous Papilloma

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Genetic Tests for Larynx Squamous Papilloma

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Anatomical Context for Larynx Squamous Papilloma

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Publications for Larynx Squamous Papilloma

Articles related to Larynx Squamous Papilloma:

#	Title	Authors	PMID	Year
1	Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ⁶²	Orita Y...Sato Y	29447361	2018
2	Human papillomavirus (HPV) in head and neck cancer. ⁶²	Syrjanen S	15753013	2005
3	Three simultaneous neoplasms of the larynx. ⁶²	Ossoff RH...Bytell DE	114938	1978

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Genes for Larynx Squamous Papilloma

Genes related to Larynx Squamous Papilloma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SRCIN1	SRC Kinase Signaling Inhibitor 1	Protein Coding	4.47	DISEASES inferred ¹⁴
2	PDLIM7	PDZ And LIM Domain 7	Protein Coding	4.18	DISEASES inferred ¹⁴
3	HBZ	Hemoglobin Subunit Zeta	Protein Coding	4.08	DISEASES inferred ¹⁴
4	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	3.99	DISEASES inferred ¹⁴
5	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.93	DISEASES inferred ¹⁴
6	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	3.68	DISEASES inferred ¹⁴
7	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	3.58	DISEASES inferred ¹⁴
8	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	3.53	DISEASES inferred ¹⁴
9	S100A8	S100 Calcium Binding Protein A8	Protein Coding	3.41	DISEASES inferred ¹⁴
10	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	3.37	DISEASES inferred ¹⁴
11	TP53	Tumor Protein P53	Protein Coding	3.18	DISEASES inferred ¹⁴
12	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	2.94	DISEASES inferred ¹⁴
13	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2.8	DISEASES inferred ¹⁴

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Variations for Larynx Squamous Papilloma

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Expression for Larynx Squamous Papilloma

Search GEO for disease gene expression data for Larynx Squamous Papilloma.

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Pathways for Larynx Squamous Papilloma

Pathways related to Larynx Squamous Papilloma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.45	TUBB4A TP53 S100A8 PSMB9 HRAS HLA-G
2	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing: Ubiquitination and Proteasome degradation ⁶⁶ Neddylation ⁶⁶	13.14	TUBB4A S100A8 PSMB9 HRAS HLA-G HLA-DRB1
3	Vitamin D receptor pathway ⁷⁴	11.94	S100A8 HLA-DRB1 CDKN2A
4	Senescence and autophagy in cancer ⁷⁴	11.45	TP53 HRAS CDKN2A
5	Transcription_P53 signaling pathway ²²	11.37	TP53 PSMB9 CDKN2A
6	Head and neck squamous cell carcinoma ⁷⁴	11.2	TP53 HRAS CDKN2A
7	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.11	TP53 HRAS HLA-DRB1 CDKN2A
8	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.75	TP53 CDKN2A
9	Bladder cancer ⁷⁴	10.73	TP53 HRAS CDKN2A
10	TP53 network ⁷⁴ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.67	TP53 CDKN2A
11	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ⁶¹	10.55	TP53 CDKN2A

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GO Terms for Larynx Squamous Papilloma

Cellular components related to Larynx Squamous Papilloma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	obsolete integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	8.62	HLA-G HLA-DRB1

Biological processes related to Larynx Squamous Papilloma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras protein signal transduction	GO:0007265	9.63	TP53 HRAS CDKN2A
2	T-helper 1 type immune response	GO:0042088	9.26	HRAS HLA-DRB1
3	cellular senescence	GO:0090398	9.1	TP53 HRAS CDKN2A

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Sources for Larynx Squamous Papilloma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LRY006 MIFTS: 23	Larynx Squamous Papilloma Categories: Cancer diseases, Oral diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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