MCID: LRY011
MIFTS: 31

Larynx Verrucous Carcinoma

Categories: Cancer diseases, Respiratory diseases, Oral diseases

Aliases & Classifications for Larynx Verrucous Carcinoma

MalaCards integrated aliases for Larynx Verrucous Carcinoma:

Name: Larynx Verrucous Carcinoma 12 15
Verrucous Carcinoma of the Larynx 12
Laryngeal Verrucous Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3752
NCIt 50 C8188
UMLS 73 C0280328

Summaries for Larynx Verrucous Carcinoma

MalaCards based summary : Larynx Verrucous Carcinoma, also known as verrucous carcinoma of the larynx, is related to laryngitis, and has symptoms including hoarseness and pain. An important gene associated with Larynx Verrucous Carcinoma is VCL (Vinculin). The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver, and related phenotypes are Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells) and digestive/alimentary

Related Diseases for Larynx Verrucous Carcinoma

Diseases related to Larynx Verrucous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 laryngitis 9.9

Symptoms & Phenotypes for Larynx Verrucous Carcinoma

UMLS symptoms related to Larynx Verrucous Carcinoma:


hoarseness, pain

GenomeRNAi Phenotypes related to Larynx Verrucous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells) GR00196-A-1 8.8 ACOT13 TP53 VCL

MGI Mouse Phenotypes related to Larynx Verrucous Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 ACOT13 TP53 VCL

Drugs & Therapeutics for Larynx Verrucous Carcinoma

Drugs for Larynx Verrucous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 191)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
2
Cisplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Docetaxel Approved, Investigational Phase 3,Phase 2,Phase 1 114977-28-5 148124
5
Cetuximab Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 205923-56-4 56842117 2333
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
8
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
9
Cevimeline Approved Phase 3 107233-08-9 83898 25137844
10
Megestrol acetate Approved, Investigational, Vet_approved Phase 3 595-33-5 11683
11
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
13
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
14
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
15
Doxepin Approved, Investigational Phase 3 1668-19-5 667477 667468
16
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
17
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
19
leucovorin Approved, Nutraceutical Phase 3,Phase 1,Phase 2 58-05-9 143 6006
20 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
21 Liver Extracts Phase 3,Phase 2,Phase 1,Not Applicable
22 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
23 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
24 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
25 Autonomic Agents Phase 3,Phase 2,Not Applicable
26 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
27 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
28 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
29 Antimetabolites Phase 3,Phase 2,Phase 1
30 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
31 Antimitotic Agents Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
33 Antirheumatic Agents Phase 3,Not Applicable
34 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Adjuvants, Anesthesia Phase 3
36 Analgesics Phase 3
37 Analgesics, Opioid Phase 3
38 Anesthetics Phase 3
39 Anesthetics, General Phase 3
40 Anesthetics, Intravenous Phase 3
41 Central Nervous System Depressants Phase 3
42 Narcotics Phase 3
43 Antifungal Agents Phase 2, Phase 3,Phase 1
44 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
45 Hormone Antagonists Phase 2, Phase 3
46 Hormones Phase 2, Phase 3,Phase 1
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
48 Steroid Synthesis Inhibitors Phase 2, Phase 3
49 Cholinergic Agents Phase 3,Not Applicable
50 Antineoplastic Agents, Hormonal Phase 3

Interventional clinical trials:

(show top 50) (show all 128)
# Name Status NCT ID Phase Drugs
1 PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer Unknown status NCT00720070 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
4 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3 fluconazole
5 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3 cevimeline hydrochloride
6 Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract Completed NCT00765440 Phase 3
7 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3 megestrol acetate
8 Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00002476 Phase 3 fluorouracil;leucovorin calcium;methotrexate;vincristine sulfate
9 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
10 Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer Completed NCT00820248 Phase 3 cisplatin
11 Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Active, not recruiting NCT00588770 Phase 3 Carboplatin;Cisplatin;Docetaxel;Fluorouracil
12 Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Active, not recruiting NCT01810913 Phase 2, Phase 3 cisplatin;docetaxel
13 Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Active, not recruiting NCT00956007 Phase 3
14 CD2 Lozenges in Preventing Acute Oral Mucositis in Patients With Head and Neck Cancer Receiving Radiotherapy and Chemotherapy Withdrawn NCT01545687 Phase 3
15 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3 Hypericum perforatum;docetaxel
16 Docetaxel, Cisplatin, and Fluorouracil Followed By Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer Unknown status NCT00721513 Phase 2 cisplatin;docetaxel;fluorouracil
17 Cisplatin-Epinephrine Injectable Gel Plus Paclitaxel and Carboplatin in Treating Patients With Recurrent Head and Neck Cancer Unknown status NCT00022217 Phase 2 carboplatin;cisplatin-e therapeutic implant;paclitaxel
18 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
19 Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery Completed NCT02007200 Phase 2 Soy Isoflavones
20 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed NCT01256385 Phase 2 Temsirolimus
21 Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. Completed NCT01469429 Phase 1, Phase 2 chemoprevention;chemoprevention
22 Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed NCT00513435 Phase 2 saracatinib
23 Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab Completed NCT00939627 Phase 2 sorafenib tosylate
24 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
25 Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed NCT00507767 Phase 2 dasatinib
26 Lapatinib Ditosylate in Treating Patients With Metastatic or Recurrent Head and Neck Cancer Completed NCT00114283 Phase 2 lapatinib ditosylate
27 S0420, Sorafenib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed NCT00096512 Phase 2 sorafenib tosylate
28 Ixabepilone in Treating Patients With Metastatic or Recurrent Squamous Cell Cancer of the Head and Neck Completed NCT00033618 Phase 2 ixabepilone
29 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer Completed NCT00101348 Phase 1, Phase 2 erlotinib hydrochloride
30 Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer Completed NCT00458978 Phase 2 Cediranib Maleate
31 Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer Completed NCT01316757 Phase 2 paclitaxel;carboplatin;erlotinib hydrochloride
32 Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Completed NCT00103259 Phase 2 bortezomib;irinotecan hydrochloride
33 SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed NCT00095628 Phase 2 ispinesib
34 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
35 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
36 Docetaxel in Treating Patients With Solid Tumors Completed NCT00003565 Phase 2 docetaxel
37 Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer Completed NCT00448552 Phase 2 capecitabine;oxaliplatin
38 Cetuximab and Stereotactic Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery Completed NCT00738868 Phase 2
39 Irinotecan and Cisplatin in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed NCT00639769 Phase 2 cisplatin;irinotecan hydrochloride
40 Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck Completed NCT00720304 Phase 2 docetaxel;erlotinib hydrochloride
41 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Completed NCT00004901 Phase 1, Phase 2 ethynyluracil;fluorouracil;hydroxyurea
42 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2 capecitabine;carboplatin;epirubicin hydrochloride
43 Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors Completed NCT00019331 Phase 2 DetoxPC
44 Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer Completed NCT00509665 Phase 2 doxorubicin hydrochloride;gemcitabine hydrochloride
45 Everolimus, Carboplatin, and Paclitaxel in Locally Advanced Head and Neck Cancer That Cannot Be Removed by Surgery Completed NCT01333085 Phase 1, Phase 2 carboplatin;RAD001;paclitaxel
46 Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Completed NCT00021333 Phase 2 cisplatin;paclitaxel
47 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery Recruiting NCT02734537 Phase 2 Cisplatin
48 Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer Active, not recruiting NCT02048020 Phase 2 paclitaxel;carboplatin
49 PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Active, not recruiting NCT01816984 Phase 1, Phase 2 PI3K inhibitor BKM120
50 Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck Active, not recruiting NCT01044433 Phase 2 lapatinib ditosylate;capecitabine

Search NIH Clinical Center for Larynx Verrucous Carcinoma

Genetic Tests for Larynx Verrucous Carcinoma

Anatomical Context for Larynx Verrucous Carcinoma

MalaCards organs/tissues related to Larynx Verrucous Carcinoma:

41
Lung, Brain, Liver, Skin, Breast, Kidney, Lymph Node

Publications for Larynx Verrucous Carcinoma

Articles related to Larynx Verrucous Carcinoma:

(show all 31)
# Title Authors Year
1
Verrucous carcinoma of the larynx presenting as a hairy lesion. ( 24823530 )
2014
2
Verrucous carcinoma of the larynx: determining the best treatment option. ( 16626921 )
2006
3
Pathologic quiz case: laryngeal lesion in an elderly man. Verrucous carcinoma of the larynx. ( 15628892 )
2005
4
Verrucous carcinoma of the larynx: a review of 53 patients. ( 9570624 )
1998
5
Verrucous carcinoma of the larynx. ( 9596216 )
1998
6
Verrucous carcinoma of the larynx presenting as a hairy whitish tumor. ( 18493443 )
1997
7
CO2 laser surgery for verrucous carcinoma of the larynx. ( 9261788 )
1997
8
Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx. ( 8869607 )
1996
9
Verrucous carcinoma of the larynx. ( 7816455 )
1995
10
Outcome following radiotherapy in verrucous carcinoma of the larynx. ( 7790246 )
1995
11
Verrucous carcinoma of the larynx: role of human papillomavirus, radiation, and surgery. ( 8382761 )
1993
12
Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx. ( 8384679 )
1993
13
Management of verrucous carcinoma of the larynx. ( 2070533 )
1991
14
Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. ( 2757559 )
1989
15
Diagnosis and management of verrucous carcinoma of the larynx. ( 3154665 )
1988
16
Verrucous carcinoma of the larynx. ( 3240742 )
1988
17
Verrucous carcinoma of the larynx. ( 3138618 )
1988
18
Verrucous carcinoma of the larynx: problems of diagnosis and treatment. ( 3343571 )
1988
19
Late response of verrucous carcinoma of the larynx to radiotherapy. ( 3356941 )
1988
20
Verrucous carcinoma of the larynx--a misnomer. ( 3662922 )
1987
21
Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx. ( 3004723 )
1986
22
Verrucous carcinoma of the larynx. Possible human papillomavirus etiology. ( 2996475 )
1985
23
Verrucous carcinoma of the larynx. ( 7172465 )
1982
24
Ackerman's tumor (verrucous carcinoma) of the larynx: a clinicopathologic study of 77 cases. ( 7417957 )
1980
25
Verrucous carcinoma of the larynx. ( 926962 )
1977
26
Verrucous carcinoma of the larynx management by radiotherapy and surgery. ( 949161 )
1976
27
Verrucous carcinoma of the larynx. ( 1186399 )
1975
28
Verrucous carcinoma of the larynx. ( 1173340 )
1975
29
Toronto experience of verrucous carcinoma of the larynx. ( 1139424 )
1975
30
Verrucous carcinoma of the larynx. - A study of its pathologic anatomy. ( 1139423 )
1975
31
Verrucous carcinoma of the larynx. ( 1139425 )
1975

Variations for Larynx Verrucous Carcinoma

Expression for Larynx Verrucous Carcinoma

Search GEO for disease gene expression data for Larynx Verrucous Carcinoma.

Pathways for Larynx Verrucous Carcinoma

GO Terms for Larynx Verrucous Carcinoma

Biological processes related to Larynx Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homotetramerization GO:0051289 8.62 ACOT13 TP53

Molecular functions related to Larynx Verrucous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 8.62 TP53 VCL

Sources for Larynx Verrucous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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