MCID: LSS003
MIFTS: 44

Lassa Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

MalaCards integrated aliases for Lassa Fever:

Name: Lassa Fever 12 76 59 55 3 44 15 73
Lassa Hemorrhagic Fever 59
Lf 59

Characteristics:

Orphanet epidemiological data:

59
lassa fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Lassa Fever

CDC : 3 Lassa fever is endemic in parts of west Africa including Sierra Leone, Liberia, Guinea and Nigeria; however, other neighboring countries are also at risk, as the animal vector for Lassa virus, the "multimammate rat" (Mastomys natalensis) is distributed throughout the region. In 2009, the first case from Mali was reported in a traveler living in southern Mali; Ghana reported its first cases in late 2011. Isolated cases have also been reported in Côte d’Ivoire and Burkina Faso and there is serologic evidence of Lassa virus infection in Togo and Benin.

MalaCards based summary : Lassa Fever, also known as lassa hemorrhagic fever, is related to lymphocytic choriomeningitis and hemorrhagic fever, and has symptoms including fever, retrosternal pain and sore throat. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are hearing impairment and conjunctivitis

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

Wikipedia : 76 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 lymphocytic choriomeningitis 29.2 AXL DAG1
2 hemorrhagic fever 11.5
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
4 sensorineural hearing loss 10.1
5 vaccinia 10.1
6 ebola hemorrhagic fever 10.1
7 encephalopathy 10.1
8 aging 9.8
9 diabetes mellitus 9.8
10 hepatitis 9.8
11 mucositis 9.8
12 hepatitis a 9.8
13 rift valley fever 9.8
14 coccidioidomycosis 9.8
15 smallpox 9.8
16 stomatitis 9.8
17 yellow fever 9.8
18 viral hemorrhagic fever 9.8
19 inclusion conjunctivitis 9.7 CD40LG GPR132
20 myocarditis 9.6 CD40LG DAG1
21 la crosse encephalitis 9.4 AXL CD40LG

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to Lassa Fever

Symptoms & Phenotypes for Lassa Fever

Symptoms:

12 (show all 12)
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Human phenotypes related to Lassa Fever:

59 32 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000365
2 conjunctivitis 59 32 frequent (33%) Frequent (79-30%) HP:0000509
3 skin rash 59 32 occasional (7.5%) Occasional (29-5%) HP:0000988
4 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
5 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
6 subcutaneous nodule 59 32 frequent (33%) Frequent (79-30%) HP:0001482
7 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
8 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
9 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
10 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
11 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
12 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
13 pleural effusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0002202
14 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
15 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
16 vertigo 59 32 frequent (33%) Frequent (79-30%) HP:0002321
17 increased intracranial pressure 59 32 occasional (7.5%) Occasional (29-5%) HP:0002516
18 lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002716
19 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
20 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
21 spontaneous abortion 59 32 hallmark (90%) Very frequent (99-80%) HP:0005268
22 cardiorespiratory arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0006543
23 chemosis 59 32 frequent (33%) Frequent (79-30%) HP:0012375
24 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
25 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
26 palpebral edema 59 32 frequent (33%) Frequent (79-30%) HP:0100540
27 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
28 recurrent pharyngitis 59 32 frequent (33%) Frequent (79-30%) HP:0100776
29 menometrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0400008

GenomeRNAi Phenotypes related to Lassa Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CD40LG CH25H DAG1 GPR132
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CD40LG CH25H DAG1 GPR132

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
2 Anti-Infective Agents Phase 2,Not Applicable
3 Antimetabolites Phase 2,Not Applicable
4 Antiviral Agents Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali Completed NCT02311387
3 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Not Applicable Ribavirin

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

MalaCards organs/tissues related to Lassa Fever:

41
Skin, Testes, T Cells, Neutrophil, Lung

Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 300)
# Title Authors Year
1
Lassa fever in Nigeria: the tale of a reactive health system. ( 29739558 )
2018
2
Expression and X-Ray Structural Determination of the Nucleoprotein of Lassa Fever Virus. ( 28986833 )
2018
3
Nigeria hit by unprecedented Lassa fever outbreak. ( 29590055 )
2018
4
Predicting outcome and improving treatment for Lassa fever. ( 29523495 )
2018
5
Mortality Among Confirmed Lassa Fever Cases During the 2015-2016 Outbreak in Nigeria. ( 29267063 )
2018
6
Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development. ( 29581897 )
2018
7
Diagnostics for Lassa Fever: Detecting Host Antibody Responses. ( 28986826 )
2018
8
Deadly Lassa-fever outbreak tests Nigeria's revamped health agency. ( 29565399 )
2018
9
Early detection of Lassa fever: the need for point-of-care diagnostics. ( 29856352 )
2018
10
Movement Patterns of Small Rodents in Lassa Fever-Endemic Villages in Guinea. ( 29572697 )
2018
11
Lassa fever and global health security. ( 29582756 )
2018
12
Re-emerging Lassa fever outbreaks in Nigeria: Re-enforcing "One Health" community surveillance and emergency response practice. ( 29703243 )
2018
13
Lassa fever in Nigeria: the great unknown. ( 29486937 )
2018
14
Absence of Nosocomial Transmission of Imported Lassa Fever during Use of Standard Barrier Nursing Methods. ( 29775178 )
2018
15
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever. ( 29651117 )
2018
16
Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study. ( 29523497 )
2018
17
The challenges of detecting and responding to a Lassa fever outbreak in an Ebola-affected setting. ( 29138016 )
2018
18
Mitigation of the global impact of Lassa fever: Have we investigated enough about this Arenavirus? - A bibliometric analysis of Lassa Fever research. ( 29944957 )
2018
19
Lassa fever-induced sensorineural hearing loss: A neglected public health and social burden. ( 29470486 )
2018
20
Mitigating the risks of global spread of Lassa fever at the 2018 Hajj pilgrimage. ( 29709659 )
2018
21
Discharge Criteria for Patient With Lassa Fever Infection. ( 29186289 )
2018
22
Moving Lassa Fever Research and Care Into the 21st Century. ( 28863471 )
2017
23
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. ( 28869611 )
2017
24
Lessons learnt from imported cases and onward transmission of Lassa fever in Europe support broader management of viral haemorrhagic fevers. ( 29019310 )
2017
25
Epidemic preparedness and management: A guide on Lassa fever outbreak preparedness plan. ( 29238121 )
2017
26
Knowledge Attitude and Practices Toward Lassa Fever Control and Prevention Among Residents of Ile-Ife, Southwest Nigeria. ( 28511600 )
2017
27
A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever. ( 29045192 )
2017
28
Lassa fever. ( 28701331 )
2017
29
Management of a Lassa fever outbreak, Rhineland-Palatinate, Germany, 2016. ( 29019309 )
2017
30
Understanding the cryptic nature of Lassa fever in West Africa. ( 28875769 )
2017
31
Laboratory Diagnosis of Lassa Fever. ( 28404674 )
2017
32
Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016. ( 29391958 )
2017
33
Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. ( 28922385 )
2017
34
Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever. ( 29017278 )
2017
35
Control measures following a case of imported Lassa fever from Togo, North Rhine Westphalia, Germany, 2016. ( 29019307 )
2017
36
Outbreak of lassa fever in Nigeria: measures for prevention and control. ( 27347299 )
2016
37
Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan. ( 27051545 )
2016
38
Lassa fever. ( 27333233 )
2016
39
Vaccine platforms to control Lassa fever. ( 27136941 )
2016
40
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. ( 27402779 )
2016
41
Epidemic focus: Lassa Fever. ( 27236868 )
2016
42
Lassa fever: another threat from West Africa. ( 28265442 )
2016
43
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. ( 27191716 )
2016
44
Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever. ( 26895631 )
2016
45
Postexposure prophylaxis for Lassa fever: Experience from a recent outbreak in Nigeria. ( 27630390 )
2016
46
Molecular confirmation of Lassa fever imported into Ghana. ( 28879105 )
2016
47
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit. ( 27975074 )
2016
48
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. ( 26927465 )
2016
49
Mapping of Lassa fever cases in post-conflict Liberia, 2008-2012: a descriptive and categorical analysis of age, gender and seasonal pattern. ( 25693822 )
2015
50
Efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model for Lassa fever. ( 26531247 )
2015

Variations for Lassa Fever

Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 GP2 PIGC

GO Terms for Lassa Fever

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 8.96 AXL CD40LG
2 viral entry into host cell GO:0046718 8.62 AXL DAG1

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 AXL DAG1

Sources for Lassa Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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