MCID: LSS003
MIFTS: 44

Lassa Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

MalaCards integrated aliases for Lassa Fever:

Name: Lassa Fever 12 77 60 56 3 45 15 17 74
Lassa Hemorrhagic Fever 60
Lf 60

Characteristics:

Orphanet epidemiological data:

60
lassa fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Lassa Fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary : Lassa Fever, also known as lassa hemorrhagic fever, is related to lymphocytic choriomeningitis and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus, and has symptoms including fever, vomiting and abdominal pain. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs Ribavirin and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are fever and fatigue

CDC : 3 Lassa fever is an animal-borne, or zoonotic, acute viral illness. It is endemic in parts of West Africa including Sierra Leone, Liberia, Guinea and Nigeria. Neighboring countries are also at risk, as the animal vector for Lassa virus, the “multimammate rat” (Mastomys natalensis) is distributed throughout the region.

Wikipedia : 77 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to Lassa Fever

Symptoms & Phenotypes for Lassa Fever

Human phenotypes related to Lassa Fever:

60 33 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
3 spontaneous abortion 60 33 hallmark (90%) Very frequent (99-80%) HP:0005268
4 menometrorrhagia 60 33 hallmark (90%) Very frequent (99-80%) HP:0400008
5 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
6 subcutaneous nodule 60 33 frequent (33%) Frequent (79-30%) HP:0001482
7 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
8 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
9 thrombocytopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001873
10 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
11 palpebral edema 60 33 frequent (33%) Frequent (79-30%) HP:0100540
12 chemosis 60 33 frequent (33%) Frequent (79-30%) HP:0012375
13 vertigo 60 33 frequent (33%) Frequent (79-30%) HP:0002321
14 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
15 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
16 diarrhea 60 33 frequent (33%) Frequent (79-30%) HP:0002014
17 recurrent pharyngitis 60 33 frequent (33%) Frequent (79-30%) HP:0100776
18 conjunctivitis 60 33 frequent (33%) Frequent (79-30%) HP:0000509
19 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
20 leukopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001882
21 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
22 hearing impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0000365
23 increased intracranial pressure 60 33 occasional (7.5%) Occasional (29-5%) HP:0002516
24 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
25 skin rash 60 33 occasional (7.5%) Occasional (29-5%) HP:0000988
26 lethargy 60 33 occasional (7.5%) Occasional (29-5%) HP:0001254
27 lymphadenopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002716
28 pleural effusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0002202
29 cardiorespiratory arrest 60 33 occasional (7.5%) Occasional (29-5%) HP:0006543

Symptoms:

12 (show all 12)
  • fever
  • vomiting
  • abdominal pain
  • back pain
  • diarrhea
  • conjunctivitis
  • cough
  • sore throat
  • mucosal bleeding
  • facial swelling
  • retrosternal pain
  • proteinuria (protein in the urine)

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
2 Antiviral Agents Phase 2,Not Applicable
3 Anti-Infective Agents Phase 2,Not Applicable
4 Antimetabolites Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers Recruiting NCT03805984 Phase 1 INO-4500;Placebo
3 Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali Completed NCT02311387
4 Cardiovascular Function and Ribavirin Pharmacokinetics and Pharmacodynamics in Patients With Lassa Fever Recruiting NCT03889106 Ribavirin
5 Lassa Fever Clinical Course and Prognostic Factors in Nigeria Recruiting NCT03655561
6 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Not Applicable Ribavirin
7 Prevalence and Incidence of Lassa Virus Infection in Southern Mali Not yet recruiting NCT03783143

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

MalaCards organs/tissues related to Lassa Fever:

42
Skin, Testes, T Cells, Lung, Neutrophil, Brain, Eye

Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 346)
# Title Authors Year
1
Lassa Fever in Travelers from West Africa, 1969-2016. ( 30666924 )
2019
2
Potential for Seasonal Lassa Fever Case Exportation from Nigeria. ( 30693858 )
2019
3
Brexit impacts, quitting coal and Lassa-fever outbreak. ( 30700887 )
2019
4
Sequencing for rapid response to Lassa fever. ( 30728532 )
2019
5
A recombinant vesicular stomatitis-based Lassa fever vaccine elicits rapid and long-term protection from lethal Lassa virus infection in guinea pigs. ( 30774999 )
2019
6
Data set on Lassa fever in post-conflict Sierra Leone. ( 30788396 )
2019
7
Increase in Lassa Fever Cases in Nigeria, January-March 2018. ( 30807268 )
2019
8
Nigeria's unending war with Lassa fever. ( 30833112 )
2019
9
Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings. ( 30899575 )
2019
10
Diagnostic applications for Lassa fever in limited-resource settings. ( 30899576 )
2019
11
A medical records and data capture and management system for Lassa fever in Sierra Leone: Approach, implementation, and challenges. ( 30921383 )
2019
12
A cluster of nosocomial Lassa fever cases in a tertiary health facility in Nigeria: description and lessons learned, 2018. ( 30930184 )
2019
13
Progress and challenges of Lassa fever control in Nigeria. ( 31002078 )
2019
14
Evaluation of rodent control to fight Lassa fever based on field data and mathematical modelling. ( 31007139 )
2019
15
Vaccine platforms for the prevention of Lassa fever. ( 31026485 )
2019
16
Quantifying the seasonal drivers of transmission for Lassa fever in Nigeria. ( 31056054 )
2019
17
Hygiene Practices in a Nigerian rural Community during Lassa Fever Epidemic. ( 31080395 )
2019
18
New methodologies for the estimation of population vulnerability to diseases: a case study of Lassa fever and Ebola in Nigeria and Sierra Leone. ( 31104602 )
2019
19
Epidemiologic and Clinical Features of Lassa Fever Outbreak in Nigeria, January 1-May 6, 2018. ( 31107222 )
2019
20
Understanding Lassa fever. ( 30606832 )
2019
21
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak. ( 30606844 )
2019
22
Mass media reportage of Lassa fever in Nigeria: a viewpoint. ( 30657006 )
2019
23
Lassa fever: Time to eradicate the deadly disease in Nigeria. ( 30666035 )
2019
24
Mass media awareness campaign and the prevention of the spread of Lassa fever in the rural communities of Ebonyi State, Nigeria: Impact evaluation. ( 30854180 )
2018
25
Pre-clinical development of a vaccine against Lassa fever. ( 31015807 )
2018
26
Diagnostics for Lassa Fever: Detecting Host Antibody Responses. ( 28986826 )
2018
27
Expression and X-Ray Structural Determination of the Nucleoprotein of Lassa Fever Virus. ( 28986833 )
2018
28
The challenges of detecting and responding to a Lassa fever outbreak in an Ebola-affected setting. ( 29138016 )
2018
29
Discharge Criteria for Patient With Lassa Fever Infection. ( 29186289 )
2018
30
Mortality Among Confirmed Lassa Fever Cases During the 2015-2016 Outbreak in Nigeria. ( 29267063 )
2018
31
Lassa fever-induced sensorineural hearing loss: A neglected public health and social burden. ( 29470486 )
2018
32
Lassa fever in Nigeria: the great unknown. ( 29486937 )
2018
33
Predicting outcome and improving treatment for Lassa fever. ( 29523495 )
2018
34
Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study. ( 29523497 )
2018
35
Deadly Lassa-fever outbreak tests Nigeria's revamped health agency. ( 29565399 )
2018
36
Movement Patterns of Small Rodents in Lassa Fever-Endemic Villages in Guinea. ( 29572697 )
2018
37
Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development. ( 29581897 )
2018
38
Lassa fever and global health security. ( 29582756 )
2018
39
Nigeria hit by unprecedented Lassa fever outbreak. ( 29590055 )
2018
40
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever. ( 29651117 )
2018
41
Re-emerging Lassa fever outbreaks in Nigeria: Re-enforcing "One Health" community surveillance and emergency response practice. ( 29703243 )
2018
42
Mitigating the risks of global spread of Lassa fever at the 2018 Hajj pilgrimage. ( 29709659 )
2018
43
Lassa fever in Nigeria: the tale of a reactive health system. ( 29739558 )
2018
44
Absence of Nosocomial Transmission of Imported Lassa Fever during Use of Standard Barrier Nursing Methods. ( 29775178 )
2018
45
Early detection of Lassa fever: the need for point-of-care diagnostics. ( 29856352 )
2018
46
Mitigation of the global impact of Lassa fever: Have we investigated enough about this Arenavirus? - A bibliometric analysis of Lassa Fever research. ( 29944957 )
2018
47
A Case of Lassa Fever Diagnosed at a Community Hospital-Minnesota 2014. ( 30035149 )
2018
48
Case Report: Imported Case of Lassa Fever - New Jersey, May 2015. ( 30062993 )
2018
49
Lessons Learnt from Epidemiological Investigation of Lassa Fever Outbreak in a Southwest State of Nigeria December 2015 to April 2016. ( 30094105 )
2018
50
Lassa fever outbreaks in Nigeria. ( 30111178 )
2018

Variations for Lassa Fever

Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 GP2 PIGC

GO Terms for Lassa Fever

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 8.96 AXL DAG1
2 skeletal muscle tissue regeneration GO:0043403 8.62 DAG1 LARGE1

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 AXL DAG1

Sources for Lassa Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....