Lassa Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as lassa hemorrhagic fever, is related to yellow fever and lymphocytic choriomeningitis, and has symptoms including proteinuria, vomiting and fever. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Favipiravir and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and monocytes, and related phenotypes are fever and increased circulating igm level

CDC: ² Lassa fever is an animal-borne, or zoonotic, acute viral illness. It is endemic in parts of West Africa including Sierra Leone, Liberia, Guinea and Nigeria. Neighboring countries are also at risk, as the animal vector for Lassa virus, the "multimammate rat" (Mastomys natalensis) is distributed throughout the region.

Orphanet: ⁵⁸ Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock and multi-organ system failure.

Wikipedia: ⁷⁵ Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

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Related Diseases for Lassa Fever

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)

#	Related Disease	Score	Top Affiliating Genes
1	yellow fever	30.7	RIGI IFNB1 IFNAR1
2	lymphocytic choriomeningitis	30.7	RIGI IRF3 DAG1 CD209
3	vaccinia	30.5	IRF3 IFNB1 IFNA1 ERVW-1
4	myocarditis	30.4	IFNA1 IFIH1 DAG1 CD4
5	stomatitis	30.2	RIGI IFNB1 IFNA1 IFIH1 CD4 BST2
6	aseptic meningitis	30.2	IFNA1 CD8A CD4
7	marburg hemorrhagic fever	30.2	IFNB1 IFNA1 GTPBP1 GP2 ERVW-1 CD8A
8	rabies	30.2	RIGI LAMP1 IRF3 IFNA1
9	diarrhea	30.1	RIGI IRF3 IFNB1 IFNA1
10	meningoencephalitis	30.0	CD8A CD4 ACE2
11	plague	29.9	RIGI CD8A CD4 ACE2
12	blood platelet disease	29.9	IFNA1 CD8A CD4 ACE2
13	leprosy 3	29.8	IFNB1 CD8A CD4 CD209
14	bolivian hemorrhagic fever	29.8	RIGI MBTPS1 IFNA1 GTPBP1 GP2 ERVW-1
15	hepatitis	29.7	RIGI IRF3 IFNB1 IFNA1 IFIH1
16	ebola hemorrhagic fever	29.7	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
17	respiratory failure	29.7	IFNB1 IFNA1 CD8A CD4 ACE2
18	thrombocytopenia	29.6	RIGI IFNB1 IFNA1 IFIH1 CD4 CD209
19	zika fever	29.5	RIGI IFNB1 IFNAR1 IFNA1 ERVW-1 CD209
20	dengue disease	29.5	RIGI IFNB1 IFNAR1 IFNA1 ERVW-1 CD8A
21	viral infectious disease	29.3	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
22	measles	29.1	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
23	severe acute respiratory syndrome	28.9	RIGI IRF3 IFNB1 IFNA1 IFIH1 CD209
24	hemorrhagic disease	10.5
25	sensorineural hearing loss	10.4
26	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.4
27	blessig's cysts	10.4	GTPBP1 GP2
28	de quervain disease	10.4	GTPBP1 GP2
29	intestinal tuberculosis	10.4	GP2 CD4
30	st. louis encephalitis	10.3	IFNA1 ERVW-1
31	hilar lung neoplasm	10.3	CD8A CD4
32	oral tuberculosis	10.3	CD8A CD4
33	early yaws	10.3	CD8A CD4
34	ventilation pneumonitis	10.3	CD8A CD4
35	diffuse infiltrative lymphocytosis syndrome	10.3	CD8A CD4
36	wissler-fanconi syndrome	10.3	CD8A CD4
37	autoimmune lymphoproliferative syndrome, type iia	10.3	CD8A CD4
38	encephalitozoonosis	10.3	CD8A CD4
39	type 1 diabetes mellitus 23	10.3	CD8A CD4
40	cork-handlers' disease	10.3	CD8A CD4
41	typhoid fever	10.3
42	primary agammaglobulinemia	10.3
43	ross river fever	10.3	IFNB1 ERVW-1
44	follicular mucinosis	10.3	CD8A CD4
45	suppurative lymphadenitis	10.3	CD8A CD4
46	bird fancier's lung	10.3	CD8A CD4
47	listeria meningitis	10.3	IFNB1 CD8A
48	parapsoriasis	10.3	CD8A CD4
49	primary syphilis	10.3	CD8A CD4
50	alkhurma hemorrhagic fever	10.3	IFNAR1 ERVW-1

Graphical network of the top 20 diseases related to Lassa Fever:

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Symptoms & Phenotypes for Lassa Fever

Human phenotypes related to Lassa Fever:

⁵⁸ ³⁰ (show all 28)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	increased circulating igm level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003496
3	menometrorrhagia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0400008
4	asthenia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0025406
5	viremia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0020071
6	nausea and vomiting ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002017
7	dysphagia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002015
8	muscle weakness ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001324
9	abdominal pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002027
10	cough ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012735
11	chest pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100749
12	headache ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002315
13	pharyngitis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025439
14	seizure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001250
15	hearing impairment ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000365
16	jaundice ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000952
17	back pain ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003418
18	dyspnea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002094
19	arthralgia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002829
20	conjunctivitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000509
21	sepsis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100806
22	abnormal bleeding ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001892
23	premature birth ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001622
24	diarrhea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002014
25	oliguria ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100520
26	facial edema ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000282
27	shock ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031273
28	spontaneous abortion ⁵⁸		Very frequent (99-80%)

Symptoms:

¹¹ (show all 12)

• proteinuria
• vomiting
• fever
• back pain
• abdominal pain
• cough

• conjunctivitis
• diarrhea
• sore throat
• retrosternal pain
• facial swelling
• mucosal bleeding

GenomeRNAi Phenotypes related to Lassa Fever according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	ACE2 BST2 CD209 CD4 CD8A DAG1
2	no effect	GR00402-S-2	10.17	BST2 CD209 CD4 DAG1 ERVW-1 GTPBP1

MGI Mouse Phenotypes related to Lassa Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.03	ACE2 BST2 CD209 CD4 CD8A DAG1
2	immune system	MP:0005387	10.03	ACE2 BST2 CD209 CD4 CD8A GP2
3	renal/urinary system	MP:0005367	9.97	ACE2 BST2 CD209 CD8A GP2 IFIH1
4	hematopoietic system	MP:0005397	9.83	ACE2 BST2 CD209 CD4 CD8A GP2
5	integument	MP:0010771	9.28	ACE2 BST2 CD4 CD8A GP2 IFIH1

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Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Favipiravir

Approved, Investigational

Phase 2

259793-96-9

492405

2

Pharmaceutical Solutions

Phase 1

3

Vaccines

Phase 1

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Pharmacokinetics, Tolerability and Safety of Favipiravir Compared to Ribavirin for the Treatment of Lassa Fever: A Randomized Controlled Open Label Phase II Clinical Trial	Active, not recruiting	NCT04907682	Phase 2	Ribavirin iv;Favipiravir
2	Treatment of Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever) With Intravenous Ribavirin in Department of Defense (DOD) Associated Medical Treatment Facilities: A Phase 2 Study	Withdrawn	NCT00992693	Phase 2	Ribavirin (Virazole) Injection
3	Dose-Ranging Study to Evaluate the Safety, Tolerability and Immunogenicity of INO-4500 in Combination With Electroporation in Healthy Volunteers in Ghana	Completed	NCT04093076	Phase 1	INO-4500;Placebo
4	Study to Evaluate the Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers	Completed	NCT03805984	Phase 1	INO-4500;Placebo
5	A Randomized, Placebo-controlled Trial to Evaluate the Optimal Dose of MV-LASV, a New Vaccine Against LASSA Virus Infection, Regarding Safety, Tolerability & Immunogenicity in Healthy Volunteers Consisting of an Unblinded Dose Escalation & an Observer-blinded Treatment Phase	Completed	NCT04055454	Phase 1
6	A Phase 1 Randomized, Double-blinded, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults in Good General Heath	Recruiting	NCT04794218	Phase 1	rVSV∆G-LASV-GPC
7	Cardiovascular Function and Ribavirin Pharmacokinetics and Pharmacodynamics in Lassa Fever Patients in Nigeria: a Prospective Observational Cohort Study	Completed	NCT04285034
8	Study of the Seroprevalence and the Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali	Completed	NCT02311387
9	Observational Cohort Study of Lassa Fever Clinical Course and Prognostic Factors in an Epidemic Context in Nigeria	Recruiting	NCT03655561
10	Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever)	Recruiting	NCT02483260		Ribavirin
11	Serosurvey for Prevalence and Incidence of Lassa Virus Infection in Southern Mali	Recruiting	NCT03783143
12	Cardiovascular Function and Ribavirin Pharmacokinetics and Pharmacodynamics in Patients With Lassa Fever	Terminated	NCT03889106		Ribavirin

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

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Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

Organs/tissues related to Lassa Fever:

MalaCards : T Cells, Liver, Monocytes, Myeloid, Endothelial, Kidney, Lung

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Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 989)

#	Title	Authors	PMID	Year
1	Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell. ⁵³ ⁶²	Rojek JM...Kunz S	17761532	2007
2	O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. ⁵³ ⁶²	Imperiali M...Oxenius A	16254364	2005
3	Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. ⁵³ ⁶²	Kunz S...Oldstone MB	16254363	2005
4	Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus. ⁵³ ⁶²	Kunz S...Oldstone MB	15246261	2004
5	Viral RNA and infectious virus in mucosal specimens from guinea pigs modelling early phases of lethal and non-lethal Lassa fever. ⁶²	Welch SR...Spengler JR	35481464	2022
6	Hearing loss in outbred Hartley guinea pigs experimentally infected with Pichinde virus as a surrogate model of human mammarenaviral hemorrhagic fevers. ⁶²	Brisse M...Ly H	35758052	2022
7	Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys. ⁶²	Mateo M...Baize S	35437094	2022
8	Lassa antiviral LHF-535 protects guinea pigs from lethal challenge. ⁶²	Cashman KA...Amberg SM	36402782	2022
9	Towards specie-specific ensemble vaccine candidates against mammarenaviruses using optimized structural vaccinology pipeline and molecular modelling approaches. ⁶²	Khan T...Wei DQ	36165863	2022
10	Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors. ⁶²	LaVergne SM...Sullivan BM	36441765	2022
11	The Pan-ErbB tyrosine kinase inhibitor afatinib inhibits multiple steps of the mammarenavirus life cycle. ⁶²	Mizuma K...Iwasaki M	36183499	2022
12	Exotic viral hepatitis: A review on epidemiology, pathogenesis, and treatment. ⁶²	van Leeuwen LPM...Goeijenbier M	35817222	2022
13	Ecological interactions, local people awareness and practices on rodent-borne diseases in Africa: A review. ⁶²	Banda A...Muboko N	36343664	2022
14	The COVID-19 Impact on the Trends in Yellow Fever and Lassa Fever Infections in Nigeria. ⁶²	Opara NU...Hlongwana KW	36412749	2022
15	Risk communication sources and knowledge of Lassa fever in Nigeria: An impact analysis. ⁶²	Ben-Enukora CA...Adekanye O	36406662	2022
16	Lassa fever cases suffer from severe underreporting based on reported fatalities. ⁶²	Simons D	36413115	2022
17	Safety and Pharmacokinetics of LHF-535, a Potential Treatment for Lassa Fever, in Healthy Adults. ⁶²	Amberg SM...Heald AE	36314868	2022
18	After action review of the response to an outbreak of Lassa fever in Sierra Leone, 2019: Best practices and lessons learnt. ⁶²	Njuguna C...Yoti Z	36197925	2022
19	Evaluation of Three Clinical Prediction Tools to Predict Mortality in Hospitalized Patients with Lassa Fever. ⁶²	Chiosi JJ...Grant DS	35895416	2022
20	Immunoinformatics analysis to design novel epitope based vaccine candidate targeting the glycoprotein and nucleoprotein of Lassa mammarenavirus (LASMV) using strains from Nigeria. ⁶²	Abass OA...Abiodun AA	33719908	2022
21	Understanding Immune Responses to Lassa Virus Infection and to Its Candidate Vaccines. ⁶²	Murphy H...Ly H	36298533	2022
22	Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections. ⁶²	Okogbenin S...Omansen T	36148915	2022
23	Lassa Virus Countermeasures. ⁶²	Melnik LI	36253593	2022
24	Assessing the Brighton Collaboration Case Definition of Sensorineural Hearing Loss in Ghana. ⁶²	Bukari I...Chen WJ	36252804	2022
25	A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. ⁶²	Li H...Saphire EO	36288283	2022
26	Identifying immunodominant multi-epitopes from the envelope glycoprotein of the Lassa mammarenavirus as vaccine candidate for Lassa fever. ⁶²	Rowaiye AB...Agbalalah T	36451670	2022
27	Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice. ⁶²	Reyna RA...Paessler S	36289695	2022
28	Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades. ⁶²	Klitting R...Dellicour S	36167835	2022
29	Adapting public health response through lessons learnt: Nigeria's experience from Lassa fever and COVID-19. ⁶²	Saleh F...Ihekweazu CA	36130796	2022
30	Lassa fever - the road ahead. ⁶²	Garry RF	36097163	2022
31	Epidemiological characteristics of Lassa fever cases in Liberia: a retrospective analysis of surveillance data, 2019-2020. ⁶²	Jetoh RW...MaCauley J	35817283	2022
32	First confirmed diagnosis of Lassa fever in Kebbi state, northwest Nigeria: Lessons to be learned. ⁶²	Otubogun F...Sanni N	36164684	2022
33	Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria. ⁶²	Happi AN...Happi CT	35913205	2022
34	Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies1. ⁶²	Cheng HY...Sterne JAC	35876478	2022
35	Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line. ⁶²	Di D...Liang Y	35913216	2022
36	Neutralizing Antibodies against Lassa Virus Lineage I. ⁶²	Buck TK...Hastie KM	35730904	2022
37	A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever. ⁶²	Cross RW...Geisbert TW	35858566	2022
38	Pharmacokinetics of ribavirin in the treatment of Lassa fever: An observational clinical study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria. ⁶²	Groger M...Erameh C	35881530	2022
39	Lassa Virus Infection: a Summary for Clinicians. ⁶²	Raabe V...Evans JD	35395384	2022
40	Contemporary and emerging pharmacotherapeutic agents for the treatment of Lassa viral haemorrhagic fever disease. ⁶²	Joseph AA...Olatunji OA	35296886	2022
41	Detection of Lassa Virus-Reactive IgG Antibodies in Wild Rodents: Validation of a Capture Enzyme-Linked Immunological Assay. ⁶²	Soubrier H...Fichet-Calvet E	35632733	2022
42	Pathology and Pathogenesis of Lassa Fever: Novel Immunohistochemical Findings in Fatal Cases and Clinico-pathologic Correlation. ⁶²	Shieh WJ...Zaki SR	34463715	2022
43	Pathogens that Cause Illness Clinically Indistinguishable from Lassa Fever, Nigeria, 2018. ⁶²	Ashcroft JW...Ihekweazu C	35226800	2022
44	Persistent viral shedding after acute Lassa fever: thorough evidence arouses more noteworthy concerns. ⁶²	Ye W...Zhang F	35544091	2022
45	CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model. ⁶²	Maruyama J...Paessler S	35605008	2022
46	Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. ⁶²	Enriquez AS...Hastie KM	35613585	2022
47	Beyond Lassa Fever: Systemic and structural barriers to disease detection and response in Sierra Leone. ⁶²	Rohan H	35587495	2022
48	Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review. ⁶²	Yan LD...Peck RN	35272495	2022
49	COVID-19 and Lassa fever in Nigeria: A deadly alliance? ⁶²	Musa SS...He D	35108609	2022
50	A challenging response to a Lassa fever outbreak in a non endemic area of Sierra Leone in 2019 with export of cases to The Netherlands. ⁶²	Njuguna C...Yoti Z	35167968	2022

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Genes for Lassa Fever

Genes related to Lassa Fever (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DAG1	Dystroglycan 1	Protein Coding	43.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins Functions (show sections)	15246261 17761532 16254363 (more) 16254364
2	IFI30	IFI30 Lysosomal Thiol Reductase	Protein Coding	12.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	GTPBP1	GTP Binding Protein 1	Protein Coding	8.18	DISEASES inferred ¹⁴
4	GP2	Glycoprotein 2	Protein Coding	7.93	DISEASES inferred ¹⁴
5	TMBIM4	Transmembrane BAX Inhibitor Motif Containing 4	Protein Coding	7.78	GeneCards inferred via : Publications (show sections)
6	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	7.04	DISEASES inferred ¹⁴
7	ERVW-1	Endogenous Retrovirus Group W Member 1, Envelope	Protein Coding	6.3	DISEASES inferred ¹⁴
8	RIGI	RNA Sensor RIG-I	Protein Coding	6.08	DISEASES inferred ¹⁴
9	IFNA1	Interferon Alpha 1	Protein Coding	6.05	DISEASES inferred ¹⁴
10	CD8A	CD8a Molecule	Protein Coding	5.88	DISEASES inferred ¹⁴
11	LAMP1	Lysosomal Associated Membrane Protein 1	Protein Coding	5.79	DISEASES inferred ¹⁴
12	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	5.77	DISEASES inferred ¹⁴
13	CD4	CD4 Molecule	Protein Coding	5.73	DISEASES inferred ¹⁴
14	IFNB1	Interferon Beta 1	Protein Coding	5.72	DISEASES inferred ¹⁴
15	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	5.71	DISEASES inferred ¹⁴
16	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	5.71	DISEASES inferred ¹⁴
17	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	5.69	DISEASES inferred ¹⁴
18	IRF3	Interferon Regulatory Factor 3	Protein Coding	5.63	DISEASES inferred ¹⁴
19	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	5.6	DISEASES inferred ¹⁴
20	CD209	CD209 Molecule	Protein Coding	5.59	DISEASES inferred ¹⁴
21	LARGE1	LARGE Xylosyl- And Glucuronyltransferase 1	Protein Coding	5.57	DISEASES inferred ¹⁴
22	CLEC4G	C-Type Lectin Domain Family 4 Member G	Protein Coding	5.51	DISEASES inferred ¹⁴
23	NPC1	NPC Intracellular Cholesterol Transporter 1	Protein Coding	5.5	DISEASES inferred ¹⁴

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Variations for Lassa Fever

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Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

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Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.83	BST2 CD209 CD4 CD8A IFI30 IFIH1
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.71	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.19	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFI30
4	SARS-CoV-2 Infection ⁶⁶ Show member pathways SARS-CoV Infections ⁶⁶ SARS-CoV-2 activates/modulates innate and adaptive immune responses ⁶⁶ SARS-CoV-2-host interactions ⁶⁶	13.08	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
5	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.53	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
6	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.5	IRF3 IFNB1 IFNAR1 IFNA1 BST2
7	NF-kappaB Signaling ³	12.48	RIGI IRF3 IFNA1 IFIH1 CD8A
8	SARS-CoV-1-host interactions ⁶⁶ Show member pathways SARS-CoV-1 activates/modulates innate immune responses ⁶⁶ SARS-CoV-1 Infection ⁶⁶ SARS-CoV-1 targets host intracellular signalling and regulatory pathways ⁶⁶	12.41	RIGI IRF3 IFIH1 BST2 ACE2
9	DDX58/IFIH1-mediated induction of interferon-alpha/beta ⁶⁶ Show member pathways Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of DDX58/IFIH1 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ Novel intracellular components of RIG-I-like receptor pathway ⁷⁴ SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation ⁷⁴ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶	12.35	RIGI IRF3 IFNB1 IFNA1 IFIH1
10	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ⁷⁴ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ Selenium micronutrient network ⁷⁴ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.28	RIGI IRF3 IFNB1 IFNA1
11	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.19	RIGI IRF3 IFNB1 IFNAR1 IFNA1 IFI30
12	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.98	IFNB1 IFNAR1 DAG1 CD8A CD4
13	Ebola virus infection in host ⁷⁴	11.97	BST2 CD209 IRF3 RIGI
14	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.9	LAMP1 CD8A CD4 CD209
15	Interferon Pathway ⁶⁴	11.73	IFNB1 IFNAR1 IFNA1
16	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.66	IFNB1 CD8A CD4 ACE2
17	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.6	IFNB1 CD8A CD4 CD209
18	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.33	RIGI IRF3 IFNB1 ACE2
19	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	11.08	RIGI IRF3 IFNB1 IFNAR1 IFIH1 ACE2
20	mRNA vaccine activation of dendritic cell and induction of IFN-1 ⁷⁴	10.54	IFIH1 IRF3 RIGI
21	Pathways of nucleic acid metabolism and innate immune sensing ⁷⁴	10.46	RIGI IRF3 IFNB1 IFIH1

Sources

GO Terms for Lassa Fever

Cellular components related to Lassa Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016021	10.33	ACE2 BST2 CD209 CD4 CD8A DAG1
2	membrane	GO:0016020	10.33	ACE2 BST2 CD209 CD4 CD8A DAG1
3	external side of plasma membrane	GO:0009897	9.7	LAMP1 GP2 DAG1 CD8A CD4 CD209
4	membrane raft	GO:0045121	9.28	GP2 DAG1 CD4 BST2 ACE2

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to virus	GO:0051607	10.21	RIGI IRF3 IFNB1 IFNA1 IFIH1 BST2
2	cytosolic pattern recognition receptor signaling pathway	GO:0002753	10.13	RIGI IFIH1
3	cytosolic pattern recognition receptor signaling pathway	GO:0039528	10.13	RIGI IFIH1
4	response to virus	GO:0009615	10.1	BST2 IFIH1 IFNAR1 IFNB1 RIGI
5	viral entry into host cell	GO:0046718	10.02	LAMP1 DAG1 CD4 CD209 ACE2
6	negative regulation of viral genome replication	GO:0045071	10.01	IFNB1 IFIH1 BST2
7	positive regulation of interferon-beta production	GO:0032728	9.99	RIGI IRF3 IFIH1
8	type I interferon-mediated signaling pathway	GO:0060337	9.97	IRF3 IFNB1 IFNAR1 IFNA1
9	positive regulation of interferon-alpha production	GO:0032727	9.95	IFIH1 IRF3 RIGI
10	positive regulation of response to cytokine stimulus	GO:0060760	9.87	RIGI IFIH1
11	detection of virus	GO:0009597	9.85	RIGI IFIH1
12	cellular response to virus	GO:0098586	9.85	IRF3 IFNB1 IFNAR1 IFNA1 IFIH1
13	MDA-5 signaling pathway	GO:0039530	9.8	IRF3 IFIH1
14	response to exogenous dsRNA	GO:0043330	9.8	IFNA1 IFNB1 IRF3 RIGI
15	regulation of type III interferon production	GO:0034344	9.76	RIGI IFIH1
16	defense response to other organism	GO:0098542	9.56	RIGI IFIH1
17	cellular response to exogenous dsRNA	GO:0071360	9.56	RIGI IRF3 IFNB1 IFIH1
18	immune system process	GO:0002376	9.32	RIGI IRF3 IFIH1 IFI30 GP2 CD8A

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	virus receptor activity	GO:0001618	9.32	LAMP1 DAG1 CD4 CD209 ACE2

Sources

Sources for Lassa Fever

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

LF MCID: LSS003 MIFTS: 53	Lassa Fever (LF) Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Lassa Fever (LF)

Aliases & Classifications for Lassa Fever

MalaCards integrated aliases for Lassa Fever:

Characteristics:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Lassa Fever

Related Diseases for Lassa Fever

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lassa Fever:

Symptoms & Phenotypes for Lassa Fever

Human phenotypes related to Lassa Fever:

Symptoms:

GenomeRNAi Phenotypes related to Lassa Fever according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Lassa Fever:

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

Organs/tissues related to Lassa Fever:

Publications for Lassa Fever

Articles related to Lassa Fever:

Genes for Lassa Fever

Genes related to Lassa Fever (0 elite genes):

Variations for Lassa Fever

Expression for Lassa Fever

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

GO Terms for Lassa Fever

Cellular components related to Lassa Fever according to GeneCards Suite gene sharing:

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

Sources for Lassa Fever