MCID: LTC001
MIFTS: 31

Late Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Late Congenital Syphilis

MalaCards integrated aliases for Late Congenital Syphilis:

Name: Late Congenital Syphilis 11 14 16 71
Neurosyphilis, Juvenile 71
Juvenile Neurosyphilis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10039
ICD9CM 34 090.4 090.5
MeSH 43 D009494
SNOMED-CT 68 187350002 4243004
ICD10 31 A50.5 A50.7
UMLS 71 C0153132 C0153136 C0554634

Summaries for Late Congenital Syphilis

Disease Ontology: 11 A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary: Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to syphilis and congenital syphilis, and has symptoms including optic atrophy, gummatous ulcers and periosteal lesions. An important gene associated with Late Congenital Syphilis is PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma). Affiliated tissues include tongue and bone, and related phenotypes are cardiovascular system and immune system

Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 syphilis 31.0 GPT FOXP3 CRP
2 congenital syphilis 11.3
3 skeletal tuberculosis 10.2 PPP2R3C CRP
4 orbital osteomyelitis 10.2 F2 CRP
5 achenbach syndrome 10.2 F2 CRP
6 synovial angioma 10.2 F2 CRP
7 femoral neuropathy 10.2 F2 CRP
8 blue toe syndrome 10.2 F2 CRP
9 renal pelvis squamous cell carcinoma 10.2 F2 CRP
10 subclavian steal syndrome 10.2 F2 CRP
11 hematocele of tunica vaginalis testis 10.2 F2 CRP
12 waterhouse-friderichsen syndrome 10.2 F2 CRP
13 internal hemorrhoid 10.2 F2 CRP
14 cavernous sinus thrombosis 10.2 F2 CRP
15 libman-sacks endocarditis 10.2 F2 CRP
16 nonbacterial thrombotic endocarditis 10.2 F2 CRP
17 subdural empyema 10.2 F2 CRP
18 epidural abscess 10.2 F2 CRP
19 lemierre's syndrome 10.2 F2 CRP
20 branch retinal artery occlusion 10.2 F2 CRP
21 hemopericardium 10.2 F2 CRP
22 acute cor pulmonale 10.2 F2 CRP
23 acute pulmonary heart disease 10.2 F2 CRP
24 intracranial sinus thrombosis 10.2 F2 CRP
25 cholesterol embolism 10.2 F2 CRP
26 ureterolithiasis 10.2 F2 CRP
27 abducens palsy 10.2 F2 CRP
28 keratitis, hereditary 10.2
29 thoracic outlet syndrome 10.2 F2 CRP
30 mediastinitis 10.2 F2 CRP
31 macrophage activation syndrome 10.1 CRP ANGPT1
32 sagittal sinus thrombosis 10.1 F2 CRP
33 mastoiditis 10.1 F2 CRP
34 sclerosing hepatic carcinoma 10.1 PDPN F2
35 hypertensive encephalopathy 10.1 F2 CRP
36 splenic tuberculosis 10.1 F2 CRP
37 intracranial embolism 10.1 F2 CRP
38 central retinal artery occlusion 10.1 F2 CRP
39 cauda equina syndrome 10.1 F2 CRP
40 buerger disease 10.1 F2 CRP
41 lymphangitis 10.1 PDPN CRP
42 intracranial hypotension 10.1 F2 CRP
43 ischemic colitis 10.1 F2 CRP
44 epiglottis cancer 10.1 PDPN ENG
45 bone squamous cell carcinoma 10.1 FOXP3 ENG
46 supine hypotensive syndrome 10.1 F2 CRP
47 cranial nerve palsy 10.1 F2 CRP
48 familiar ovarian carcinoma 10.1 ENG ANGPT1
49 necrotizing fasciitis 10.1 F2 CRP
50 congenital granular cell tumor 10.1 PDPN ENG

Graphical network of the top 20 diseases related to Late Congenital Syphilis:



Diseases related to Late Congenital Syphilis

Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

11
  • optic atrophy
  • gummatous ulcers
  • periosteal lesions
  • paresis
  • tabes
  • interstitial keratitis
  • sensorineural deafness
  • dental deformities

MGI Mouse Phenotypes related to Late Congenital Syphilis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 ANGPT1 CD36 CRP ENG F2 FOXP3
2 immune system MP:0005387 9.28 ANGPT1 CD36 CRP ENG F2 FOXP3

Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials, NIH Clinical Center for Late Congenital Syphilis

Genetic Tests for Late Congenital Syphilis

Anatomical Context for Late Congenital Syphilis

Organs/tissues related to Late Congenital Syphilis:

MalaCards : Tongue, Bone

Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Neurosyphilis: a series of 178 cases at the 3rd-level hospital of Marrakesh (Morocco). 62
33942164 2021
2
[Late congenital syphilis: case report]. 62
31339283 2019
3
Early detection of congenital syphilis. 62
25231043 2014
4
Palatal perforation due to late congenital syphilis. 62
23625469 2014
5
[Gumma of the face revealing a late congenital syphilis]. 62
24570790 2013
6
Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. 62
23919053 2013
7
Syphilis Infection during pregnancy: fetal risks and clinical management. 62
22829747 2012
8
Clinical aspects of congenital syphilis with Hutchinson's triad. 62
22670010 2011
9
Higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. 62
21498006 2011
10
Congenital syphilis: early- and late-stage findings of rhagades and dental anomalies. 62
21133996 2011
11
A case of congenital syphilis with Hutchinson's triad. 62
21799574 2011
12
George Higoumenakis (1895-1983): Greek dermatologist. 62
19401507 2009
13
[Osteoarticular manifestations of late congenital syphilis]. 62
18678465 2008
14
Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. 62
17062094 2006
15
[Issues of congenital syphilis in the past twenty years. II. Clinical picture]. 62
16649151 2006
16
The continuing scourge of congenital syphilis in 21st century: a case report. 62
16005354 2005
17
Phthisis bulbi caused by late congenital syphilis untreated until adulthood. 62
15767072 2005
18
[Right oculomotor nerve palsy due to juvenile neurosyphilis]. 62
14968585 2004
19
[Curable dementia revealing late congenital syphilis]. 62
12829337 2003
20
[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]. 62
11055060 2000
21
Confirmatory serological testing of blood donors positive on TPHA screening in Singapore. 62
9433950 1997
22
Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. 62
7930923 1994
23
Congenital syphilis: report of twelve cases. 62
8368066 1993
24
Late-onset congenital syphilis. A retrospective look at University of Iowa Hospital admissions. 62
1827452 1991
25
[Bone pain in adults as the first symptom of late congenital syphilis]. 62
2323317 1990
26
The prevalence of positive serological tests for syphilis among elderly hospital patients. 62
2629490 1989
27
Probable late congenital syphilis presenting as Clutton joints. 62
2769640 1989
28
A case of late congenital syphilis at the Metropolitan Museum of Art, New York. 62
3067596 1988
29
Congenital syphilis has not disappeared. 62
3277016 1988
30
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. 62
3276855 1988
31
Acquired syphilis in a patient with late congenital syphilis. 62
3616853 1987
32
[A case of belated diagnosis of late congenital syphilis]. 62
3447380 1987
33
[A case of late congenital syphilis which has remained undiagnosed and untreated for more than 30 years]. 62
3784058 1986
34
[Case of late congenital syphilis]. 62
4090689 1985
35
The stigmata of late congenital syphilis: an analysis of 100 patients. 62
6648746 1983
36
[A case of late congenital syphilis with gummatous manifestations]. 62
7210875 1981
37
[Dystopia of the teeth ("wandering" teeth) in late congenital syphilis]. 62
7395372 1980
38
Congenital neurosyphilis and juvenile paresis: a forgotten entity? 62
7351106 1980
39
Clinical application of non-invasive electrocochleography. 62
7283880 1980
40
[2 cases of late congenital syphilis with skeletal involvement]. 62
872685 1977
41
[Case of late congenital syphilis]. 62
1014842 1976
42
Macrophage migration inhibition test in untreated syphilis. 62
1090263 1975
43
A child with nephrotic syndrome and late congenital syphilis. (Case report). 62
4456247 1974
44
[Late congenital syphilis in the light of classic and specific reactions (Nelson's reaction, FTA reaction)]. 62
4599051 1973
45
Late congenital syphilis untreated until adulthood. 62
4714656 1973
46
Leucomelanoderma in Late Congenital Syphilis. 62
29144326 1972
47
[Case report of late congenital syphilis treated with Ehrlich 606]. 62
5158331 1971
48
Manifestations of late congenital syphilis. An analysis of 271 patients. 62
4993238 1970
49
[Deafness and late congenital syphilis]. 62
5623338 1967
50
[Features of the appearance and therapy of parenchymatous keratitis in late congenital syphilis]. 62
13897692 1962

Variations for Late Congenital Syphilis

Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

Pathways for Late Congenital Syphilis

GO Terms for Late Congenital Syphilis

Biological processes related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.28 FOXP3 ENG CRP CD36 ANGPT1
2 negative regulation of protein import into nucleus GO:0042308 9.26 CD36 ANGPT1

Molecular functions related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle binding GO:0030169 9.26 CRP CD36
2 thrombospondin receptor activity GO:0070053 8.92 F2 CD36

Sources for Late Congenital Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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