Late Congenital Syphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LTC001 MIFTS: 34	Late Congenital Syphilis Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Late Congenital Syphilis

MalaCards integrated aliases for Late Congenital Syphilis:

Name: Late Congenital Syphilis ¹² ¹⁵ ¹⁷ ⁷⁰

Neurosyphilis, Juvenile ⁷⁰

Juvenile Neurosyphilis ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Neuronal diseases Skin diseases Bone diseases Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Infections with a predominantly sexual mode of transmission

Congenital syphilis

Late congenital syphilis, unspecified

Other late congenital syphilis, symptomatic

External Ids:

Disease Ontology ¹² DOID:10039

ICD9CM ³⁴ 090.4 090.5

MeSH ⁴⁴ D009494

SNOMED-CT ⁶⁷ 187350002 4243004

ICD10 ³² A50.40 A50.5 A50.7

EFO ¹⁷ EFO_0007339

UMLS ⁷⁰ C0153132 C0153136 C0554634

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Summaries for Late Congenital Syphilis

Disease Ontology : ¹² A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary : Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to syphilis and meningoencephalitis, and has symptoms including optic atrophy, gummatous ulcers and periosteal lesions. An important gene associated with Late Congenital Syphilis is PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma), and among its related pathways/superpathways are Interleukin-10 signaling and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include tongue, eye and lymph node.

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Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis	Late Congenital Syphilis
Primary Syphilis	Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Related Disease	Score	Top Affiliating Genes
1	syphilis	31.4	FOXP3 CRP
2	meningoencephalitis	29.7	CXCL10 CRP
3	congenital syphilis	10.8
4	skeletal tuberculosis	10.2	PPP2R3C CRP
5	keratitis, hereditary	10.1
6	duodenum adenoma	10.1	CRP CCL4
7	ebola hemorrhagic fever	10.1	CXCL10 CCL4
8	relapsing polychondritis	10.1	CRP CCL4
9	orchitis	10.1	FOXP3 CRP
10	alexithymia	10.1	CRP CCL4
11	multicentric castleman disease	10.1	CRP CCL4
12	castleman disease	10.1	CRP CCL4
13	autoimmune disease of blood	10.1	FOXP3 CRP
14	macrophage activation syndrome	10.1	CRP ANGPT1
15	funisitis	10.1	CRP ANGPT1
16	bronchiectasis 1	10.1	CXCL10 CRP
17	transient pseudohypoaldosteronism	10.1
18	rectal disease	10.0	FOXP3 CRP
19	infective endocarditis	10.0	CRP CCL4
20	asymptomatic neurosyphilis	10.0
21	neurosyphilis	10.0
22	hantavirus hemorrhagic fever with renal syndrome	10.0	CXCL10 CRP
23	viral pneumonia	10.0	CXCL10 CRP
24	autoimmune disease of skin and connective tissue	10.0	FOXP3 CRP
25	nose disease	10.0	FOXP3 CRP
26	bicipital tenosynovitis	10.0	ENG CRP
27	capillary lymphangioma	10.0	ENG CRP
28	viral meningitis	10.0	CXCL10 CRP
29	acute pyelonephritis	10.0	CXCL10 CRP
30	pyelonephritis	10.0	CXCL10 CRP
31	pulmonary arterial hypertension associated with congenital heart disease	10.0	ENG CRP
32	lymph node disease	10.0	FOXP3 CRP
33	mobitz type ii atrioventricular block	10.0	ENG CRP
34	coronavirus infectious disease	10.0	CXCL10 CRP
35	spinal cord disease	9.9	CXCL10 CRP
36	demyelinating disease	9.9	FOXP3 CXCL10 CCL4
37	lipodermatosclerosis	9.9	FLT1 ANGPT1
38	angiokeratoma circumscriptum	9.9	FLT1 ANGPT1
39	retinitis pigmentosa	9.9
40	branchiootic syndrome 1	9.9
41	neuroretinitis	9.9
42	pinta disease	9.9
43	yaws	9.9
44	blind hypotensive eye	9.9
45	nephrotic syndrome	9.9
46	plica syndrome	9.9
47	synovitis	9.9
48	retinitis	9.9
49	hemoglobinuria	9.9
50	interstitial keratitis	9.9

Graphical network of the top 20 diseases related to Late Congenital Syphilis:

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Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

¹²

• optic atrophy
• gummatous ulcers
• periosteal lesions
• paresis

• tabes
• interstitial keratitis
• sensorineural deafness
• dental deformities

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Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Late Congenital Syphilis

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Genetic Tests for Late Congenital Syphilis

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Anatomical Context for Late Congenital Syphilis

MalaCards organs/tissues related to Late Congenital Syphilis:

⁴⁰

Tongue, Eye, Lymph Node, Brain, Spinal Cord, Heart, Lung

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Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show top 50) (show all 68)

#	Title	Authors	PMID	Year
1	[Late congenital syphilis: case report]. ⁶¹	Amaya MA...Nastri M	31339283	2019
2	Early detection of congenital syphilis. ⁶¹	Chowdhary N...Kiran NK	25231043	2014
3	Palatal perforation due to late congenital syphilis. ⁶¹	Bagri NK...Gupta V	23625469	2014
4	Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. ⁶¹	Balaji G...Kalaivani S	23919053	2013
5	[Gumma of the face revealing a late congenital syphilis]. ⁶¹	Taghy A...Hassam B	24570790	2013
6	Syphilis Infection during pregnancy: fetal risks and clinical management. ⁶¹	De Santis M...Scambia G	22829747	2012
7	Clinical aspects of congenital syphilis with Hutchinson's triad. ⁶¹	Pessoa L...Galvao V	22670010	2011
8	Congenital syphilis: early- and late-stage findings of rhagades and dental anomalies. ⁶¹	Khetarpal S...Mostow E	21133996	2011
9	Higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. ⁶¹	Frangos CC...Frangos CC	21498006	2011
10	A case of congenital syphilis with Hutchinson's triad. ⁶¹	Singhal P...Marfatia YS	21799574	2011
11	George Higoumenakis (1895-1983): Greek dermatologist. ⁶¹	Frangos CC...Frangos CC	19401507	2009
12	[Osteoarticular manifestations of late congenital syphilis]. ⁶¹	Abdelmoula LC...Zouari R	18678465	2008
13	Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. ⁶¹	Liu C...Tang ZH	17062094	2006
14	[Issues of congenital syphilis in the past twenty years. II. Clinical picture]. ⁶¹	Kremenova S...Kremen J	16649151	2006
15	The continuing scourge of congenital syphilis in 21st century: a case report. ⁶¹	Gurlek A...Arslan A	16005354	2005
16	Phthisis bulbi caused by late congenital syphilis untreated until adulthood. ⁶¹	Uchiyama K...Sugiyama K	15767072	2005
17	[Curable dementia revealing late congenital syphilis]. ⁶¹	Ait Sab I...Kissani N	12829337	2003
18	[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]. ⁶¹	Nunes da Silva MJ...Victorino RM	11055060	2000
19	Confirmatory serological testing of blood donors positive on TPHA screening in Singapore. ⁶¹	Wong SS...Chan RK	9433950	1997
20	Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. ⁶¹	Lacy PD...Parker AJ	7930923	1994
21	Congenital syphilis: report of twelve cases. ⁶¹	Wang YJ...Chi CS	8368066	1993
22	Late-onset congenital syphilis. A retrospective look at University of Iowa Hospital admissions. ⁶¹	Digre KB...Massanari RM	1827452	1991
23	[Bone pain in adults as the first symptom of late congenital syphilis]. ⁶¹	Rauh G...Zollner N	2323317	1990
24	The prevalence of positive serological tests for syphilis among elderly hospital patients. ⁶¹	Corrado OJ...Waugh MA	2629490	1989
25	Probable late congenital syphilis presenting as Clutton joints. ⁶¹	Kabuubi JB	2769640	1989
26	A case of late congenital syphilis at the Metropolitan Museum of Art, New York. ⁶¹	Borroni G	3067596	1988
27	Congenital syphilis has not disappeared. ⁶¹	Lane GK...Oates RK	3277016	1988
28	Repair of a palatal defect associated with late congenital syphilis using a tongue flap. ⁶¹	Housego T...Nortje CJ	3276855	1988
29	Acquired syphilis in a patient with late congenital syphilis. ⁶¹	Pavithran K	3616853	1987
30	[A case of belated diagnosis of late congenital syphilis]. ⁶¹	Kim EG...Piagai LT	3447380	1987
31	[A case of late congenital syphilis which has remained undiagnosed and untreated for more than 30 years]. ⁶¹	Usami H...Miura K	3784058	1986
32	[Case of late congenital syphilis]. ⁶¹	Shevliakov LV...Tikhonovich VV	4090689	1985
33	The stigmata of late congenital syphilis: an analysis of 100 patients. ⁶¹	Fiumara NJ...Lessell S	6648746	1983
34	[A case of late congenital syphilis with gummatous manifestations]. ⁶¹	Khidyrov KhN...Plechistova LA	7210875	1981
35	[Dystopia of the teeth ("wandering" teeth) in late congenital syphilis]. ⁶¹	Il'in II	7395372	1980
36	Clinical application of non-invasive electrocochleography. ⁶¹	Mori N...Asai H	7283880	1980
37	[2 cases of late congenital syphilis with skeletal involvement]. ⁶¹	Giunti A...Giunti P	872685	1977
38	[Case of late congenital syphilis]. ⁶¹	Kaganovich EL...Khlebin KI	1014842	1976
39	Macrophage migration inhibition test in untreated syphilis. ⁶¹	Bowszyc J	1090263	1975
40	A child with nephrotic syndrome and late congenital syphilis. (Case report). ⁶¹	Zulkarnain-Malaon L...Soebagyo Singgih M	4456247	1974
41	[Late congenital syphilis in the light of classic and specific reactions (Nelson's reaction, FTA reaction)]. ⁶¹	Kozakiewicz J...Jankowska B	4599051	1973
42	Late congenital syphilis untreated until adulthood. ⁶¹	McClean AN	4714656	1973
43	Leucomelanoderma in Late Congenital Syphilis. ⁶¹	Lal S...Lamba PA	29144326	1972
44	[Case report of late congenital syphilis treated with Ehrlich 606]. ⁶¹	Weber G...Falk U	5158331	1971
45	Manifestations of late congenital syphilis. An analysis of 271 patients. ⁶¹	Fiumara NJ...Lessell S	4993238	1970
46	[Deafness and late congenital syphilis]. ⁶¹	Baron F...Dejour B	5623338	1967
47	[Features of the appearance and therapy of parenchymatous keratitis in late congenital syphilis]. ⁶¹	GENKINA GB	13897692	1962
48	Synovitis of the knee joints in late congenital syphilis. Clutton's joints. ⁶¹	BORELLA L...CLARK GM	13871252	1962
49	[Problems in the pathogenesis, clinical aspects and therapy of parenchymatous keratitis in late congenital syphilis and primary (tabetic) atrophy of the optic nerves]. ⁶¹	ROBUSTOV GV	14492963	1962
50	[Value of serological tests in detecting late congenital syphilis in adults]. ⁶¹	CZARNOTA-BOJARSKA M	13882882	1961

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Genes for Late Congenital Syphilis

Genes related to Late Congenital Syphilis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PPP2R3C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	5.87	DISEASES inferred ¹⁵
2	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	4.34	DISEASES inferred ¹⁵
3	FOXP3	Forkhead Box P3	Protein Coding	4.2	DISEASES inferred ¹⁵
4	SLC1A7	Solute Carrier Family 1 Member 7	Protein Coding	4.1	DISEASES inferred ¹⁵
5	ANGPT1	Angiopoietin 1	Protein Coding	3.85	DISEASES inferred ¹⁵
6	CRP	C-Reactive Protein	Protein Coding	3.57	DISEASES inferred ¹⁵
7	ENG	Endoglin	Protein Coding	3.5	DISEASES inferred ¹⁵
8	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	3.35	DISEASES inferred ¹⁵
9	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	3.18	DISEASES inferred ¹⁵

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Variations for Late Congenital Syphilis

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Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

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Pathways for Late Congenital Syphilis

Pathways related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Interleukin-10 signaling ⁶⁵	10.95	CXCL10 CCL4
2	IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Show member pathways IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	10.71	FOXP3 CCL4
3	Angiogenesis (WikiPathways) ¹	10.34	FLT1 ANGPT1
4	G-protein signaling_Rap2B regulation pathway ²³	9.83	FLT1 CXCL10 CCL4 ANGPT1

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GO Terms for Late Congenital Syphilis

Cellular components related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.1	FLT1 ENG CXCL10 CRP CCL4 ANGPT1

Biological processes related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	angiogenesis	GO:0001525	9.58	FLT1 ENG ANGPT1
2	positive chemotaxis	GO:0050918	9.46	CXCL10 ANGPT1
3	monocyte chemotaxis	GO:0002548	9.43	FLT1 CCL4
4	sprouting angiogenesis	GO:0002040	9.37	ENG ANGPT1
5	chemotaxis	GO:0006935	9.33	FLT1 CXCL10 CCL4
6	T cell homeostasis	GO:0043029	9.32	PPP2R3C FOXP3
7	B cell homeostasis	GO:0001782	9.26	PPP2R3C FOXP3
8	positive regulation of gene expression	GO:0010628	9.26	FOXP3 ENG CRP ANGPT1
9	response to virus	GO:0009615	8.8	FOXP3 CXCL10 CCL4

Molecular functions related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:0008009	8.62	CXCL10 CCL4

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Sources for Late Congenital Syphilis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia