Late Congenital Syphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary: Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to syphilis and congenital syphilis, and has symptoms including optic atrophy, gummatous ulcers and periosteal lesions. An important gene associated with Late Congenital Syphilis is PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma). Affiliated tissues include tongue and bone, and related phenotypes are cardiovascular system and immune system

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Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis	Late Congenital Syphilis
Primary Syphilis	Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)

#	Related Disease	Score	Top Affiliating Genes
1	syphilis	31.0	GPT FOXP3 CRP
2	congenital syphilis	11.3
3	skeletal tuberculosis	10.2	PPP2R3C CRP
4	orbital osteomyelitis	10.2	F2 CRP
5	achenbach syndrome	10.2	F2 CRP
6	synovial angioma	10.2	F2 CRP
7	femoral neuropathy	10.2	F2 CRP
8	blue toe syndrome	10.2	F2 CRP
9	renal pelvis squamous cell carcinoma	10.2	F2 CRP
10	subclavian steal syndrome	10.2	F2 CRP
11	hematocele of tunica vaginalis testis	10.2	F2 CRP
12	waterhouse-friderichsen syndrome	10.2	F2 CRP
13	internal hemorrhoid	10.2	F2 CRP
14	cavernous sinus thrombosis	10.2	F2 CRP
15	libman-sacks endocarditis	10.2	F2 CRP
16	nonbacterial thrombotic endocarditis	10.2	F2 CRP
17	subdural empyema	10.2	F2 CRP
18	epidural abscess	10.2	F2 CRP
19	lemierre's syndrome	10.2	F2 CRP
20	branch retinal artery occlusion	10.2	F2 CRP
21	hemopericardium	10.2	F2 CRP
22	acute cor pulmonale	10.2	F2 CRP
23	acute pulmonary heart disease	10.2	F2 CRP
24	intracranial sinus thrombosis	10.2	F2 CRP
25	cholesterol embolism	10.2	F2 CRP
26	ureterolithiasis	10.2	F2 CRP
27	abducens palsy	10.2	F2 CRP
28	keratitis, hereditary	10.2
29	thoracic outlet syndrome	10.2	F2 CRP
30	mediastinitis	10.2	F2 CRP
31	macrophage activation syndrome	10.1	CRP ANGPT1
32	sagittal sinus thrombosis	10.1	F2 CRP
33	mastoiditis	10.1	F2 CRP
34	sclerosing hepatic carcinoma	10.1	PDPN F2
35	hypertensive encephalopathy	10.1	F2 CRP
36	splenic tuberculosis	10.1	F2 CRP
37	intracranial embolism	10.1	F2 CRP
38	central retinal artery occlusion	10.1	F2 CRP
39	cauda equina syndrome	10.1	F2 CRP
40	buerger disease	10.1	F2 CRP
41	lymphangitis	10.1	PDPN CRP
42	intracranial hypotension	10.1	F2 CRP
43	ischemic colitis	10.1	F2 CRP
44	epiglottis cancer	10.1	PDPN ENG
45	bone squamous cell carcinoma	10.1	FOXP3 ENG
46	supine hypotensive syndrome	10.1	F2 CRP
47	cranial nerve palsy	10.1	F2 CRP
48	familiar ovarian carcinoma	10.1	ENG ANGPT1
49	necrotizing fasciitis	10.1	F2 CRP
50	congenital granular cell tumor	10.1	PDPN ENG

Graphical network of the top 20 diseases related to Late Congenital Syphilis:

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Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

¹¹

• optic atrophy
• gummatous ulcers
• periosteal lesions
• paresis

• tabes
• interstitial keratitis
• sensorineural deafness
• dental deformities

MGI Mouse Phenotypes related to Late Congenital Syphilis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.56	ANGPT1 CD36 CRP ENG F2 FOXP3
2	immune system	MP:0005387	9.28	ANGPT1 CD36 CRP ENG F2 FOXP3

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Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials, NIH Clinical Center for Late Congenital Syphilis

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Genetic Tests for Late Congenital Syphilis

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Anatomical Context for Late Congenital Syphilis

Organs/tissues related to Late Congenital Syphilis:

MalaCards : Tongue, Bone

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Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show top 50) (show all 72)

#	Title	Authors	PMID	Year
1	Neurosyphilis: a series of 178 cases at the 3rd-level hospital of Marrakesh (Morocco). ⁶²	Kissani N...Louhab N	33942164	2021
2	[Late congenital syphilis: case report]. ⁶²	Amaya MA...Nastri M	31339283	2019
3	Early detection of congenital syphilis. ⁶²	Chowdhary N...Kiran NK	25231043	2014
4	Palatal perforation due to late congenital syphilis. ⁶²	Bagri NK...Gupta V	23625469	2014
5	[Gumma of the face revealing a late congenital syphilis]. ⁶²	Taghy A...Hassam B	24570790	2013
6	Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. ⁶²	Balaji G...Kalaivani S	23919053	2013
7	Syphilis Infection during pregnancy: fetal risks and clinical management. ⁶²	De Santis M...Scambia G	22829747	2012
8	Clinical aspects of congenital syphilis with Hutchinson's triad. ⁶²	Pessoa L...Galvao V	22670010	2011
9	Higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. ⁶²	Frangos CC...Frangos CC	21498006	2011
10	Congenital syphilis: early- and late-stage findings of rhagades and dental anomalies. ⁶²	Khetarpal S...Mostow E	21133996	2011
11	A case of congenital syphilis with Hutchinson's triad. ⁶²	Singhal P...Marfatia YS	21799574	2011
12	George Higoumenakis (1895-1983): Greek dermatologist. ⁶²	Frangos CC...Frangos CC	19401507	2009
13	[Osteoarticular manifestations of late congenital syphilis]. ⁶²	Abdelmoula LC...Zouari R	18678465	2008
14	Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. ⁶²	Liu C...Tang ZH	17062094	2006
15	[Issues of congenital syphilis in the past twenty years. II. Clinical picture]. ⁶²	Kremenova S...Kremen J	16649151	2006
16	The continuing scourge of congenital syphilis in 21st century: a case report. ⁶²	Gurlek A...Arslan A	16005354	2005
17	Phthisis bulbi caused by late congenital syphilis untreated until adulthood. ⁶²	Uchiyama K...Sugiyama K	15767072	2005
18	[Right oculomotor nerve palsy due to juvenile neurosyphilis]. ⁶²	Yamasaki R...Yamashita Y	14968585	2004
19	[Curable dementia revealing late congenital syphilis]. ⁶²	Ait Sab I...Kissani N	12829337	2003
20	[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]. ⁶²	Nunes da Silva MJ...Victorino RM	11055060	2000
21	Confirmatory serological testing of blood donors positive on TPHA screening in Singapore. ⁶²	Wong SS...Chan RK	9433950	1997
22	Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. ⁶²	Lacy PD...Parker AJ	7930923	1994
23	Congenital syphilis: report of twelve cases. ⁶²	Wang YJ...Chi CS	8368066	1993
24	Late-onset congenital syphilis. A retrospective look at University of Iowa Hospital admissions. ⁶²	Digre KB...Massanari RM	1827452	1991
25	[Bone pain in adults as the first symptom of late congenital syphilis]. ⁶²	Rauh G...Zollner N	2323317	1990
26	The prevalence of positive serological tests for syphilis among elderly hospital patients. ⁶²	Corrado OJ...Waugh MA	2629490	1989
27	Probable late congenital syphilis presenting as Clutton joints. ⁶²	Kabuubi JB	2769640	1989
28	A case of late congenital syphilis at the Metropolitan Museum of Art, New York. ⁶²	Borroni G	3067596	1988
29	Congenital syphilis has not disappeared. ⁶²	Lane GK...Oates RK	3277016	1988
30	Repair of a palatal defect associated with late congenital syphilis using a tongue flap. ⁶²	Housego T...Nortje CJ	3276855	1988
31	Acquired syphilis in a patient with late congenital syphilis. ⁶²	Pavithran K	3616853	1987
32	[A case of belated diagnosis of late congenital syphilis]. ⁶²	Kim EG...Piagai LT	3447380	1987
33	[A case of late congenital syphilis which has remained undiagnosed and untreated for more than 30 years]. ⁶²	Usami H...Miura K	3784058	1986
34	[Case of late congenital syphilis]. ⁶²	Shevliakov LV...Tikhonovich VV	4090689	1985
35	The stigmata of late congenital syphilis: an analysis of 100 patients. ⁶²	Fiumara NJ...Lessell S	6648746	1983
36	[A case of late congenital syphilis with gummatous manifestations]. ⁶²	Khidyrov KhN...Plechistova LA	7210875	1981
37	[Dystopia of the teeth ("wandering" teeth) in late congenital syphilis]. ⁶²	Il'in II	7395372	1980
38	Congenital neurosyphilis and juvenile paresis: a forgotten entity? ⁶²	Wiggelinkhuizen J...Mason R	7351106	1980
39	Clinical application of non-invasive electrocochleography. ⁶²	Mori N...Asai H	7283880	1980
40	[2 cases of late congenital syphilis with skeletal involvement]. ⁶²	Giunti A...Giunti P	872685	1977
41	[Case of late congenital syphilis]. ⁶²	Kaganovich EL...Khlebin KI	1014842	1976
42	Macrophage migration inhibition test in untreated syphilis. ⁶²	Bowszyc J	1090263	1975
43	A child with nephrotic syndrome and late congenital syphilis. (Case report). ⁶²	Zulkarnain-Malaon L...Soebagyo Singgih M	4456247	1974
44	[Late congenital syphilis in the light of classic and specific reactions (Nelson's reaction, FTA reaction)]. ⁶²	Kozakiewicz J...Jankowska B	4599051	1973
45	Late congenital syphilis untreated until adulthood. ⁶²	McClean AN	4714656	1973
46	Leucomelanoderma in Late Congenital Syphilis. ⁶²	Lal S...Lamba PA	29144326	1972
47	[Case report of late congenital syphilis treated with Ehrlich 606]. ⁶²	Weber G...Falk U	5158331	1971
48	Manifestations of late congenital syphilis. An analysis of 271 patients. ⁶²	Fiumara NJ...Lessell S	4993238	1970
49	[Deafness and late congenital syphilis]. ⁶²	Baron F...Dejour B	5623338	1967
50	[Features of the appearance and therapy of parenchymatous keratitis in late congenital syphilis]. ⁶²	GENKINA GB	13897692	1962

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Genes for Late Congenital Syphilis

Genes related to Late Congenital Syphilis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PPP2R3C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	5.27	DISEASES inferred ¹⁴
2	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	3.7	DISEASES inferred ¹⁴
3	FOXP3	Forkhead Box P3	Protein Coding	3.61	DISEASES inferred ¹⁴
4	SLC1A7	Solute Carrier Family 1 Member 7	Protein Coding	3.46	DISEASES inferred ¹⁴
5	ANGPT1	Angiopoietin 1	Protein Coding	3.23	DISEASES inferred ¹⁴
6	F2	Coagulation Factor II, Thrombin	Protein Coding	3.16	DISEASES inferred ¹⁴
7	PDPN	Podoplanin	Protein Coding	3.06	DISEASES inferred ¹⁴
8	CRP	C-Reactive Protein	Protein Coding	2.91	DISEASES inferred ¹⁴
9	ENG	Endoglin	Protein Coding	2.9	DISEASES inferred ¹⁴
10	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	2.89	DISEASES inferred ¹⁴
11	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	2.84	DISEASES inferred ¹⁴
12	CD36	CD36 Molecule	Protein Coding	2.81	DISEASES inferred ¹⁴

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Variations for Late Congenital Syphilis

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Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

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Pathways for Late Congenital Syphilis

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GO Terms for Late Congenital Syphilis

Biological processes related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.28	FOXP3 ENG CRP CD36 ANGPT1
2	negative regulation of protein import into nucleus	GO:0042308	9.26	CD36 ANGPT1

Molecular functions related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	low-density lipoprotein particle binding	GO:0030169	9.26	CRP CD36
2	thrombospondin receptor activity	GO:0070053	8.92	F2 CD36

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Sources for Late Congenital Syphilis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LTC001 MIFTS: 31	Late Congenital Syphilis Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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