MCID: LTC001
MIFTS: 27

Late Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Late Congenital Syphilis

Summaries for Late Congenital Syphilis

Disease Ontology : 12 A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary : Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to congenital syphilis and syphilis, and has symptoms including optic atrophy, sensorineural deafness and gummatous ulcers. An important gene associated with Late Congenital Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include tongue, skin and bone.

Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 congenital syphilis 30.4 DDX41 EXTL3
2 syphilis 30.4 DDX41 EXTL3
3 asymptomatic neurosyphilis 29.3 DDX41 EXTL3
4 neurosyphilis 9.9
5 blind hypotensive eye 9.8
6 nephrotic syndrome 9.8
7 synovitis 9.8
8 primary syphilis 9.7 DDX41 EXTL3
9 tertiary syphilis 9.7 DDX41 EXTL3
10 latent syphilis 9.7 DDX41 EXTL3
11 secondary syphilis 9.7 DDX41 EXTL3
12 tabes dorsalis 9.6 DDX41 EXTL3
13 tertiary neurosyphilis 9.6 DDX41 EXTL3
14 primary bacterial infectious disease 9.4 DDX41 EXTL3

Graphical network of the top 20 diseases related to Late Congenital Syphilis:



Diseases related to Late Congenital Syphilis

Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

12
  • optic atrophy
  • sensorineural deafness
  • gummatous ulcers
  • periosteal lesions
  • paresis
  • tabes
  • interstitial keratitis
  • dental deformities

Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Late Congenital Syphilis

Genetic Tests for Late Congenital Syphilis

Anatomical Context for Late Congenital Syphilis

MalaCards organs/tissues related to Late Congenital Syphilis:

42
Tongue, Skin, Bone, Eye

Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show all 21)
# Title Authors Year
1
Palatal perforation due to late congenital syphilis. ( 23625469 )
2014
2
Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. ( 23919053 )
2013
3
Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. ( 17062094 )
2006
4
Phthisis bulbi caused by late congenital syphilis untreated until adulthood. ( 15767072 )
2005
5
Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. ( 7930923 )
1994
6
Probable late congenital syphilis presenting as Clutton joints. ( 2769640 )
1989
7
A case of late congenital syphilis at the Metropolitan Museum of Art, New York. ( 3067596 )
1988
8
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. ( 3276855 )
1988
9
Acquired syphilis in a patient with late congenital syphilis. ( 3616853 )
1987
10
The stigmata of late congenital syphilis: an analysis of 100 patients. ( 6648746 )
1983
11
A child with nephrotic syndrome and late congenital syphilis. (Case report). ( 4456247 )
1974
12
Late congenital syphilis untreated until adulthood. ( 4714656 )
1973
13
Leucomelanoderma in Late Congenital Syphilis. ( 29144326 )
1972
14
Manifestations of late congenital syphilis. An analysis of 271 patients. ( 4993238 )
1970
15
Synovitis of the knee joints in late congenital syphilis. Clutton's joints. ( 13871252 )
1962
16
Late congenital syphilis of the ear. ( 13001208 )
1952
17
Late congenital syphilis; an analysis of 115 cases. ( 14777891 )
1950
18
The effect of penicillin on late congenital syphilis, with special reference to the Wassermann reaction. ( 18101571 )
1948
19
Penicillin therapy of late congenital syphilis. ( 18885587 )
1948
20
A Case of late Congenital Syphilis of the Face. ( 19984273 )
1925
21
Case of Late Congenital Syphilis Manifestations. ( 19979630 )
1917

Variations for Late Congenital Syphilis

Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

Pathways for Late Congenital Syphilis

GO Terms for Late Congenital Syphilis

Sources for Late Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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