MCID: LTC001
MIFTS: 27

Late Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Late Congenital Syphilis

Summaries for Late Congenital Syphilis

Disease Ontology : 12 A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary : Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to congenital syphilis and syphilis, and has symptoms including optic atrophy, sensorineural deafness and gummatous ulcers. An important gene associated with Late Congenital Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include skin, bone and tongue.

Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 congenital syphilis 30.6 EXTL3 DDX41
2 syphilis 30.5 EXTL3 DDX41
3 asymptomatic neurosyphilis 29.5 EXTL3 DDX41
4 neurosyphilis 9.9
5 primary syphilis 9.9 EXTL3 DDX41
6 latent syphilis 9.9 EXTL3 DDX41
7 tertiary syphilis 9.8 EXTL3 DDX41
8 blind hypotensive eye 9.8
9 nephrotic syndrome 9.8
10 synovitis 9.8
11 secondary syphilis 9.8 EXTL3 DDX41
12 tabes dorsalis 9.8 EXTL3 DDX41
13 tertiary neurosyphilis 9.8 EXTL3 DDX41
14 primary bacterial infectious disease 9.7 EXTL3 DDX41

Graphical network of the top 20 diseases related to Late Congenital Syphilis:



Diseases related to Late Congenital Syphilis

Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

12
  • optic atrophy
  • sensorineural deafness
  • gummatous ulcers
  • periosteal lesions
  • paresis
  • tabes
  • interstitial keratitis
  • dental deformities

Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Late Congenital Syphilis

Genetic Tests for Late Congenital Syphilis

Anatomical Context for Late Congenital Syphilis

MalaCards organs/tissues related to Late Congenital Syphilis:

41
Skin, Bone, Tongue, Eye

Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show all 21)
# Title Authors Year
1
Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. ( 23919053 )
2013
2
Palatal Perforation Due to Late Congenital Syphilis. ( 23625469 )
2013
3
Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. ( 17062094 )
2006
4
Phthisis bulbi caused by late congenital syphilis untreated until adulthood. ( 15767072 )
2005
5
Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. ( 7930923 )
1994
6
Probable late congenital syphilis presenting as Clutton joints. ( 2769640 )
1989
7
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. ( 3276855 )
1988
8
A case of late congenital syphilis at the Metropolitan Museum of Art, New York. ( 3067596 )
1988
9
Acquired syphilis in a patient with late congenital syphilis. ( 3616853 )
1987
10
The stigmata of late congenital syphilis: an analysis of 100 patients. ( 6648746 )
1983
11
A child with nephrotic syndrome and late congenital syphilis. (Case report). ( 4456247 )
1974
12
Late congenital syphilis untreated until adulthood. ( 4714656 )
1973
13
Leucomelanoderma in Late Congenital Syphilis. ( 29144326 )
1972
14
Manifestations of late congenital syphilis. An analysis of 271 patients. ( 4993238 )
1970
15
Synovitis of the knee joints in late congenital syphilis. Clutton's joints. ( 13871252 )
1962
16
Late congenital syphilis of the ear. ( 13001208 )
1952
17
Late congenital syphilis; an analysis of 115 cases. ( 14777891 )
1950
18
Penicillin therapy of late congenital syphilis. ( 18885587 )
1948
19
The effect of penicillin on late congenital syphilis, with special reference to the Wassermann reaction. ( 18101571 )
1948
20
A Case of late Congenital Syphilis of the Face. ( 19984273 )
1925
21
Case of Late Congenital Syphilis Manifestations. ( 19979630 )
1917

Variations for Late Congenital Syphilis

Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

Pathways for Late Congenital Syphilis

GO Terms for Late Congenital Syphilis

Sources for Late Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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