MCID: LTC001
MIFTS: 34

Late Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Late Congenital Syphilis

MalaCards integrated aliases for Late Congenital Syphilis:

Name: Late Congenital Syphilis 12 15 17 70
Neurosyphilis, Juvenile 70
Juvenile Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10039
ICD9CM 34 090.4 090.5
MeSH 44 D009494
SNOMED-CT 67 187350002 4243004
UMLS 70 C0153132 C0153136 C0554634

Summaries for Late Congenital Syphilis

Disease Ontology : 12 A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has symptom gummatous ulcers, has symptom periosteal lesions, has symptom paresis, has symptom tabes, has symptom optic atrophy, has symptom interstitial keratitis, has symptom sensorineural deafness, and has symptom dental deformities.

MalaCards based summary : Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to syphilis and meningoencephalitis, and has symptoms including optic atrophy, gummatous ulcers and periosteal lesions. An important gene associated with Late Congenital Syphilis is PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma), and among its related pathways/superpathways are Interleukin-10 signaling and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include tongue, eye and lymph node.

Related Diseases for Late Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Late Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 syphilis 31.4 FOXP3 CRP
2 meningoencephalitis 29.7 CXCL10 CRP
3 congenital syphilis 10.8
4 skeletal tuberculosis 10.2 PPP2R3C CRP
5 keratitis, hereditary 10.1
6 duodenum adenoma 10.1 CRP CCL4
7 ebola hemorrhagic fever 10.1 CXCL10 CCL4
8 relapsing polychondritis 10.1 CRP CCL4
9 orchitis 10.1 FOXP3 CRP
10 alexithymia 10.1 CRP CCL4
11 multicentric castleman disease 10.1 CRP CCL4
12 castleman disease 10.1 CRP CCL4
13 autoimmune disease of blood 10.1 FOXP3 CRP
14 macrophage activation syndrome 10.1 CRP ANGPT1
15 funisitis 10.1 CRP ANGPT1
16 bronchiectasis 1 10.1 CXCL10 CRP
17 transient pseudohypoaldosteronism 10.1
18 rectal disease 10.0 FOXP3 CRP
19 infective endocarditis 10.0 CRP CCL4
20 asymptomatic neurosyphilis 10.0
21 neurosyphilis 10.0
22 hantavirus hemorrhagic fever with renal syndrome 10.0 CXCL10 CRP
23 viral pneumonia 10.0 CXCL10 CRP
24 autoimmune disease of skin and connective tissue 10.0 FOXP3 CRP
25 nose disease 10.0 FOXP3 CRP
26 bicipital tenosynovitis 10.0 ENG CRP
27 capillary lymphangioma 10.0 ENG CRP
28 viral meningitis 10.0 CXCL10 CRP
29 acute pyelonephritis 10.0 CXCL10 CRP
30 pyelonephritis 10.0 CXCL10 CRP
31 pulmonary arterial hypertension associated with congenital heart disease 10.0 ENG CRP
32 lymph node disease 10.0 FOXP3 CRP
33 mobitz type ii atrioventricular block 10.0 ENG CRP
34 coronavirus infectious disease 10.0 CXCL10 CRP
35 spinal cord disease 9.9 CXCL10 CRP
36 demyelinating disease 9.9 FOXP3 CXCL10 CCL4
37 lipodermatosclerosis 9.9 FLT1 ANGPT1
38 angiokeratoma circumscriptum 9.9 FLT1 ANGPT1
39 retinitis pigmentosa 9.9
40 branchiootic syndrome 1 9.9
41 neuroretinitis 9.9
42 pinta disease 9.9
43 yaws 9.9
44 blind hypotensive eye 9.9
45 nephrotic syndrome 9.9
46 plica syndrome 9.9
47 synovitis 9.9
48 retinitis 9.9
49 hemoglobinuria 9.9
50 interstitial keratitis 9.9

Graphical network of the top 20 diseases related to Late Congenital Syphilis:



Diseases related to Late Congenital Syphilis

Symptoms & Phenotypes for Late Congenital Syphilis

Symptoms:

12
  • optic atrophy
  • gummatous ulcers
  • periosteal lesions
  • paresis
  • tabes
  • interstitial keratitis
  • sensorineural deafness
  • dental deformities

Drugs & Therapeutics for Late Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Late Congenital Syphilis

Genetic Tests for Late Congenital Syphilis

Anatomical Context for Late Congenital Syphilis

MalaCards organs/tissues related to Late Congenital Syphilis:

40
Tongue, Eye, Lymph Node, Brain, Spinal Cord, Heart, Lung

Publications for Late Congenital Syphilis

Articles related to Late Congenital Syphilis:

(show top 50) (show all 68)
# Title Authors PMID Year
1
[Late congenital syphilis: case report]. 61
31339283 2019
2
Early detection of congenital syphilis. 61
25231043 2014
3
Palatal perforation due to late congenital syphilis. 61
23625469 2014
4
Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features. 61
23919053 2013
5
[Gumma of the face revealing a late congenital syphilis]. 61
24570790 2013
6
Syphilis Infection during pregnancy: fetal risks and clinical management. 61
22829747 2012
7
Clinical aspects of congenital syphilis with Hutchinson's triad. 61
22670010 2011
8
Congenital syphilis: early- and late-stage findings of rhagades and dental anomalies. 61
21133996 2011
9
Higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. 61
21498006 2011
10
A case of congenital syphilis with Hutchinson's triad. 61
21799574 2011
11
George Higoumenakis (1895-1983): Greek dermatologist. 61
19401507 2009
12
[Osteoarticular manifestations of late congenital syphilis]. 61
18678465 2008
13
Late congenital syphilis presenting as deletion of uvula and cardiovascular disease. 61
17062094 2006
14
[Issues of congenital syphilis in the past twenty years. II. Clinical picture]. 61
16649151 2006
15
The continuing scourge of congenital syphilis in 21st century: a case report. 61
16005354 2005
16
Phthisis bulbi caused by late congenital syphilis untreated until adulthood. 61
15767072 2005
17
[Curable dementia revealing late congenital syphilis]. 61
12829337 2003
18
[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]. 61
11055060 2000
19
Confirmatory serological testing of blood donors positive on TPHA screening in Singapore. 61
9433950 1997
20
Late congenital syphilis of the larynx and pharynx presenting at endotracheal intubation. 61
7930923 1994
21
Congenital syphilis: report of twelve cases. 61
8368066 1993
22
Late-onset congenital syphilis. A retrospective look at University of Iowa Hospital admissions. 61
1827452 1991
23
[Bone pain in adults as the first symptom of late congenital syphilis]. 61
2323317 1990
24
The prevalence of positive serological tests for syphilis among elderly hospital patients. 61
2629490 1989
25
Probable late congenital syphilis presenting as Clutton joints. 61
2769640 1989
26
A case of late congenital syphilis at the Metropolitan Museum of Art, New York. 61
3067596 1988
27
Congenital syphilis has not disappeared. 61
3277016 1988
28
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. 61
3276855 1988
29
Acquired syphilis in a patient with late congenital syphilis. 61
3616853 1987
30
[A case of belated diagnosis of late congenital syphilis]. 61
3447380 1987
31
[A case of late congenital syphilis which has remained undiagnosed and untreated for more than 30 years]. 61
3784058 1986
32
[Case of late congenital syphilis]. 61
4090689 1985
33
The stigmata of late congenital syphilis: an analysis of 100 patients. 61
6648746 1983
34
[A case of late congenital syphilis with gummatous manifestations]. 61
7210875 1981
35
[Dystopia of the teeth ("wandering" teeth) in late congenital syphilis]. 61
7395372 1980
36
Clinical application of non-invasive electrocochleography. 61
7283880 1980
37
[2 cases of late congenital syphilis with skeletal involvement]. 61
872685 1977
38
[Case of late congenital syphilis]. 61
1014842 1976
39
Macrophage migration inhibition test in untreated syphilis. 61
1090263 1975
40
A child with nephrotic syndrome and late congenital syphilis. (Case report). 61
4456247 1974
41
[Late congenital syphilis in the light of classic and specific reactions (Nelson's reaction, FTA reaction)]. 61
4599051 1973
42
Late congenital syphilis untreated until adulthood. 61
4714656 1973
43
Leucomelanoderma in Late Congenital Syphilis. 61
29144326 1972
44
[Case report of late congenital syphilis treated with Ehrlich 606]. 61
5158331 1971
45
Manifestations of late congenital syphilis. An analysis of 271 patients. 61
4993238 1970
46
[Deafness and late congenital syphilis]. 61
5623338 1967
47
[Features of the appearance and therapy of parenchymatous keratitis in late congenital syphilis]. 61
13897692 1962
48
Synovitis of the knee joints in late congenital syphilis. Clutton's joints. 61
13871252 1962
49
[Problems in the pathogenesis, clinical aspects and therapy of parenchymatous keratitis in late congenital syphilis and primary (tabetic) atrophy of the optic nerves]. 61
14492963 1962
50
[Value of serological tests in detecting late congenital syphilis in adults]. 61
13882882 1961

Variations for Late Congenital Syphilis

Expression for Late Congenital Syphilis

Search GEO for disease gene expression data for Late Congenital Syphilis.

Pathways for Late Congenital Syphilis

GO Terms for Late Congenital Syphilis

Cellular components related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 FLT1 ENG CXCL10 CRP CCL4 ANGPT1

Biological processes related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.58 FLT1 ENG ANGPT1
2 positive chemotaxis GO:0050918 9.46 CXCL10 ANGPT1
3 monocyte chemotaxis GO:0002548 9.43 FLT1 CCL4
4 sprouting angiogenesis GO:0002040 9.37 ENG ANGPT1
5 chemotaxis GO:0006935 9.33 FLT1 CXCL10 CCL4
6 T cell homeostasis GO:0043029 9.32 PPP2R3C FOXP3
7 B cell homeostasis GO:0001782 9.26 PPP2R3C FOXP3
8 positive regulation of gene expression GO:0010628 9.26 FOXP3 ENG CRP ANGPT1
9 response to virus GO:0009615 8.8 FOXP3 CXCL10 CCL4

Molecular functions related to Late Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CXCL10 CCL4

Sources for Late Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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