Late-Onset Retinal Degeneration disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LORD MCID: LTN004 MIFTS: 47	Late-Onset Retinal Degeneration (LORD) Categories: Eye diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Late-Onset Retinal Degeneration

MalaCards integrated aliases for Late-Onset Retinal Degeneration:

Name: Late-Onset Retinal Degeneration ⁵⁸ ¹² ⁵⁴ ⁶⁰ ⁷⁶ ³⁸ ³⁰ ⁶ ¹⁵ ⁷⁴

Lord ⁵⁸ ¹² ⁵⁴ ⁶⁰ ⁷⁶

Retinal Degeneration, Late-Onset, Autosomal Dominant ⁵⁸ ⁵⁴ ¹³

Autosomal Dominant Late-Onset Retinal Degeneration ¹² ⁵⁴ ⁶⁰

Pigmentary Retinopathy ⁵⁴ ⁶

Retinal Degeneration, Late-Onset ⁴¹

Retinitis Pigmentosa ⁷⁴

Characteristics:

Orphanet epidemiological data:

⁶⁰

late-onset retinal degeneration
Inheritance: Autosomal dominant; Age of onset: Adult,Elderly; Age of death: normal life expectancy;

OMIM:

⁵⁸

Inheritance:
autosomal dominant

HPO:

³³

late-onset retinal degeneration:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

Orphanet: ⁶⁰

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:0060869

OMIM ⁵⁸ 605670

KEGG ³⁸ H01130

UMLS via Orphanet ⁷⁵ C1854065

Orphanet ⁶⁰ ORPHA67042

MedGen ⁴³ C1854065

SNOMED-CT via HPO ⁷⁰ 23388006 263681008 28835009 more

UMLS ⁷⁴ C0035334 C1854065

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Summaries for Late-Onset Retinal Degeneration

NIH Rare Diseases : ⁵⁴ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 67042Disease definitionLate-onset retinal degeneration is an inherited retinal dystrophy characterized by delayed dark adaptation and nyctalopia and drusen deposits presenting in adulthood, followed by cone and rod degeneration that presents in the sixth decade of life, which leads to central vision loss. Anterior segment features such as peripupillary iris transillumination defects and abnormally long anterior zonular insertions are also observed. Choroidal neovascularization and glaucoma may occur in the late stages of the disease.Visit the Orphanet disease page for more resources.

MalaCards based summary : Late-Onset Retinal Degeneration, also known as lord, is related to hardikar syndrome and kearns-sayre syndrome. An important gene associated with Late-Onset Retinal Degeneration is C1QTNF5 (C1q And TNF Related 5), and among its related pathways/superpathways is Amino sugar and nucleotide sugar metabolism. The drugs Antioxidants and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and kidney, and related phenotypes are blindness and retinopathy

Disease Ontology : ¹² A retinal degeneration characterized by autosomal dominant inheritance of night blindness and drusen deposits, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy with onset in the fifth to sixth decade of life that has material basis in heterozygous mutation in the C1QTNF5 gene on chromosome 11q23.

OMIM : ⁵⁸ Late-onset retinal degeneration (LORD) is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy (Hayward et al., 2003). (605670)

UniProtKB/Swiss-Prot : ⁷⁶ Late-onset retinal degeneration: Autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.

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Related Diseases for Late-Onset Retinal Degeneration

Diseases in the Retinal Degeneration family:

Late-Onset Retinal Degeneration

Diseases related to Late-Onset Retinal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)

#	Related Disease	Score
1	hardikar syndrome	12.0
2	kearns-sayre syndrome	11.6
3	bardet-biedl syndrome 12	11.6
4	retinopathy, pericentral pigmentary, autosomal recessive	11.6
5	bardet-biedl syndrome 2	11.4
6	bardet-biedl syndrome 10	11.4
7	bardet-biedl syndrome 11	11.4
8	myopathy, mitochondrial, and ataxia	11.4
9	spinocerebellar ataxia 7	11.2
10	retinopathy, pericentral pigmentary, dominant	11.2
11	retinitis pigmentosa, deafness, mental retardation, and hypogonadism	11.2
12	retinopathy, pigmentary, and mental retardation	11.2
13	cockayne syndrome a	11.2
14	neurodegeneration with brain iron accumulation 1	11.2
15	mitochondrial trifunctional protein deficiency	11.2
16	cockayne syndrome b	11.0
17	microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	11.0
18	retinitis pigmentosa 1	11.0
19	retinitis pigmentosa 9	11.0
20	retinitis pigmentosa 10	11.0
21	bardet-biedl syndrome 1	11.0
22	cystinosis, late-onset juvenile or adolescent nephropathic type	11.0
23	ramon syndrome	11.0
24	xeroderma pigmentosum, complementation group d	11.0
25	xeroderma pigmentosum, complementation group f	11.0
26	xeroderma pigmentosum, complementation group g	11.0
27	retinitis pigmentosa 3	11.0
28	retinitis pigmentosa 23	11.0
29	retinitis pigmentosa 2	11.0
30	diabetes and deafness, maternally inherited	11.0
31	retinitis pigmentosa 13	11.0
32	retinitis pigmentosa 12	11.0
33	retinitis pigmentosa 14	11.0
34	retinitis pigmentosa 11	11.0
35	bardet-biedl syndrome 3	11.0
36	retinitis pigmentosa 17	11.0
37	retinitis pigmentosa 18	11.0
38	retinitis pigmentosa 19	11.0
39	usher syndrome, type if	11.0
40	retinitis pigmentosa 25	11.0
41	bardet-biedl syndrome 6	11.0
42	retinitis pigmentosa 28	11.0
43	retinitis pigmentosa 30	11.0
44	retinitis pigmentosa 7	11.0
45	retinitis pigmentosa 26	11.0
46	long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	11.0
47	retinitis pigmentosa 31	11.0
48	retinitis pigmentosa 35	11.0
49	retinitis pigmentosa 33	11.0
50	retinitis pigmentosa 36	11.0

Graphical network of the top 20 diseases related to Late-Onset Retinal Degeneration:

Sources

Symptoms & Phenotypes for Late-Onset Retinal Degeneration

Human phenotypes related to Late-Onset Retinal Degeneration:

³³ (show all 8)

#	Description	HPO Source Accession
1	blindness ³³	HP:0000618
2	retinopathy ³³	HP:0000488
3	visual loss ³³	HP:0000572
4	rod-cone dystrophy ³³	HP:0000510
5	retinal degeneration ³³	HP:0000546
6	scotoma ³³	HP:0000575
7	adult-onset night blindness ³³	HP:0007830
8	sub-rpe deposits ³³	HP:0031531

Symptoms via clinical synopsis from OMIM:

⁵⁸

Head And Neck Eyes:
night blindness beginning in the 6th decade
vision loss, severe, by the 8th decade
punctate yellow-white sub-retinal pigment epithelium (rpe) lesions
retinopathy may resemble retinitis pigmentosa
abnormal dark-adaptation, midperipheral scotoma
more

Clinical features from OMIM:

605670

GenomeRNAi Phenotypes related to Late-Onset Retinal Degeneration according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.66	EXOSC2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.66	C1QTNF5 MFRP
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.66	EXOSC2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.66	C1QTNF5 MFRP EXOSC2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.66	C1QTNF5 MFRP
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-44	9.66	C1QTNF5 MFRP
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-54	9.66	EXOSC2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-69	9.66	EXOSC2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.66	EXOSC2

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Drugs & Therapeutics for Late-Onset Retinal Degeneration

Drugs for Late-Onset Retinal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antioxidants		Phase 2
2	Anesthetics		Phase 2
3	Protective Agents		Phase 2
4	Pharmaceutical Solutions		Phase 1, Phase 2
5	Mitogens		Phase 1, Phase 2
6	Ophthalmic Solutions		Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)	Recruiting	NCT01773278	Phase 2	Antioxidants;Cholesterol
2	A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP)	Completed	NCT02110225	Phase 1, Phase 2	rhNGF 60 µg/ml eye drops solution;rhNGF 180 µg/ml eye drops solution;Placebo
3	Self-confidence Study in Patients With Argus II Artificial Retina	Recruiting	NCT03510234
4	Cell Collection to Study Eye Diseases	Recruiting	NCT01432847

Search NIH Clinical Center for Late-Onset Retinal Degeneration

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Genetic Tests for Late-Onset Retinal Degeneration

Genetic tests related to Late-Onset Retinal Degeneration:

#	Genetic test	Affiliating Genes
1	Late-Onset Retinal Degeneration ³⁰	C1QTNF5

Sources

Anatomical Context for Late-Onset Retinal Degeneration

MalaCards organs/tissues related to Late-Onset Retinal Degeneration:

⁴²

Eye, Brain, Kidney, Retina, Testes, Breast, Bone

Sources

Publications for Late-Onset Retinal Degeneration

Articles related to Late-Onset Retinal Degeneration:

(show top 50) (show all 654)

#	Title	Authors	Year
1	Multimodal imaging of late-onset retinal degeneration complicated by bilateral choroidal neovascularization. ( 30692649 )	Mandal N...Lotery AJ	2019
2	Commentary: Shall we stop looking for the lord of the ring? ( 30772038 )	Di Mauro M...Calafiore AM	2019
3	Late-Onset Retinal Degeneration. ( 30578496 )	Tsang SH...Sharma T	2018
4	Ten tips for becoming a Time Lord ( 29621857 )	Knight AW...Lembke T	2018
5	Pathological and Microbiological Study of Mortality in a Captive Breeding Colony of the Endangered Lord Howe Island Stick Insect ( Dryococelus australis). ( 29661123 )	Bayley C...Lynch M	2018
6	The Lord Buddha destigmatizes mental illness. ( 29736077 )	Somasundaram O...Murthy T	2018
7	'Tax pharma companies if they fail to act on AMR', says Review chief Lord O'Neill. ( 29954991 )		2018
8	Lord of The Crowns: A New Precious in the Kingdom of Clustomesogens. ( 29989341 )	Guy K...Molard Y	2018
9	Ingestion of marine debris by Wedge-tailed Shearwaters (Ardenna pacifica) on Lord Howe Island, Australia during 2005-2018. ( 30041356 )	Lavers JL...Bond AL	2018
10	A new genus and new species of Meropathina from Lord Howe Island (Coleoptera: Hydraenidae). ( 30313914 )	Perkins PD	2018
11	The Lord of the Bacteria: The fellowship of the leader and other serine protease inhibitors. ( 30569850 )	Burchacka E...Sie?czyk M	2018
12	Lord Adrian, MD, PRS, OM. ( 29241189 )	Pearce JMS	2018
13	Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration. ( 28939808 )	Stanton C.M....Hayward C.	2017
14	Cataract surgery in patients with late-onset retinal degeneration. ( 28917403 )	Papastavrou V.T....Browning A.C.	2017
15	Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description. ( 28694134 )	Chen KA...Andrews PI	2017
16	The lord of the broken rings: African porocephaliasis, an emerging radiological diagnosis in developed countries. ( 27680970 )	Martinot M...Candolfi E	2017
17	Lord of the incomplete rings. ( 28126804 )	Hurtley SM	2017
18	Development and Dark Wizards: Teaching Psychopathology with Lord Voldemort. ( 28233261 )	Lis E...Tuineag M	2017
19	Lord of the rings. ( 28428378 )	Hand E	2017
20	Alternative splicing: The lord of the rings. ( 28470187 )	Ariel F...Crespi M	2017
21	One Health pioneer Lord Soulsby dies. ( 28500148 )		2017
22	Proteomic analysis of Lupinus angustifolius (var. Zeus and Bojar) and Lupinus luteus (var. Lord and Parys) seed proteins and their hydrolysates. ( 28516510 )	Czubinski J...Lampart-Szczapa E	2017
23	Lord Soulsby of Swaffham Prior. ( 28522634 )		2017
24	Siva - The Mad Lord: A Puranic perspective. ( 28529371 )	Somasundaram O...Murthy T	2017
25	Cyphastrea salae, a new species of hard coral from Lord Howe Island, Australia (Scleractinia, Merulinidae). ( 28769608 )	Baird AH...Huang D	2017
26	Celebrating the sesquicentennial of Lord Joseph Lister. ( 28920662 )	Nakayama DK	2017
27	Keeping of brachycephalic breeds 'not cool', says Lord as debate continues on dog welfare. ( 28939781 )		2017
28	The lord of the rings. ( 28942977 )	Miceli A	2017
29	Museum Genomics Confirms that the Lord Howe Island Stick Insect Survived Extinction. ( 28988864 )	Mikheyev AS...Yeates D	2017
30	Lord Soulsby of Swaffham Prior, 23 June 1926-8 May 2017. ( 29091213 )	Wise R	2017
31	The Alchemical Manuscripts of David Lindsay (1587-1641), Lord Lindsay of Balcarres. ( 29338655 )	Pascual-Valderrama IM...P?rez-Pariente J	2017
32	Simultaneous quantification of DNA damage and mitochondrial copy number by long-run DNA-damage quantification (LORD-Q). ( 29348835 )	Dannenmann B...Schulze-Osthoff K	2017
33	Lord Ernest Jackson Lawson Soulsby (1926–2017) – pro memoria ( 29420876 )	Paw?owski ZS	2017
34	LONGITUDINAL STRUCTURAL CHANGES IN LATE-ONSET RETINAL DEGENERATION. ( 27388725 )	Cukras C....Sieving P.A.	2016
35	Lord Lister's antiseptic steam spray. ( 24585627 )	Kirkup J	2016
36	Stable fixation of a madreporic Lord femoral prosthesis at 31-year follow-up in a total hip arthroplasty: A case report. ( 26708946 )	Judas FM...Lucas FM	2016
37	Which is the "lord" of the aortic rings? ( 26831925 )	Raanani E	2016
38	Lord Carter's model hospitals aim to save the NHS £5 billion a year. ( 26884007 )	Sprinks J	2016
39	Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. ( 26918303 )	Kelch BA	2016
40	One legacy of Lord Briggs is the value placed on nurse research. ( 27008147 )	Adams J	2016
41	The hardships of being a Sith Lord: implications of the biopsychosocial model in a space opera. ( 27105743 )	Berg RM...Plovsing RR	2016
42	Lord Willis: new nursing role is 'not a substitute'. ( 27141710 )		2016
43	Lord Walton of Detchant. ( 27142764 )	Macaulay T...Payne D	2016
44	Lord Walton of Detchant - obituary. ( 27272108 )	Hanna MG	2016
45	Comment: "If you can't measure it, you can't improve it" (Lord Kelvin). ( 27581215 )	Kuhle J	2016
46	Editorial Commentary: Helping Those Who Seek the Company of "Lord Stanley": Hockey Players and Hip Injuries Highlight the Current State and Future Challenges in Understanding, Treating, and Preventing Nonarthritic Hip Disease. ( 27594336 )	Christoforetti J	2016
47	Erratum for the article Lord 2016. ( 27622660 )	Biddle S	2016
48	John Walton, Lord Walton of Detchant: a man of influence and goodwill. ( 27803016 )	Compston A	2016
49	Guild of Nurses at the Lord Mayor's Show. ( 27897749 )		2016
50	Doctors need dragging out of their comfort zone to avert the antimicrobial crisis, says lord. ( 27913378 )	Freer J	2016

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Genes for Late-Onset Retinal Degeneration

Genes related to Late-Onset Retinal Degeneration (1 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	C1QTNF5	C1q And TNF Related 5	Protein Coding	1298.12	Molecular basis known ⁵⁸ Causative germline mutation ⁶⁰ Causative variation ⁷⁶ Genetic Tests ³⁰ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
2	MFRP	Membrane Frizzled-Related Protein	Protein Coding	26.22	GeneCards inferred via : Publications Variants (show sections)
3	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	16.48	DISEASES inferred ¹⁵
4	DXO	Decapping Exoribonuclease	Protein Coding	15.66	DISEASES inferred ¹⁵
5	EXOSC2	Exosome Component 2	Protein Coding	15.41	DISEASES inferred ¹⁵
6	DLGAP4	DLG Associated Protein 4	Protein Coding	15.16	DISEASES inferred ¹⁵
7	NPL	N-Acetylneuraminate Pyruvate Lyase	Protein Coding	15.02	DISEASES inferred ¹⁵
8	HKDC1	Hexokinase Domain Containing 1	Protein Coding	15.01	DISEASES inferred ¹⁵
9	IGFBP7	Insulin Like Growth Factor Binding Protein 7	Protein Coding	14.91	DISEASES inferred ¹⁵
10	BARX1	BARX Homeobox 1	Protein Coding	14.88	DISEASES inferred ¹⁵
11	ADGRL1	Adhesion G Protein-Coupled Receptor L1	Protein Coding	14.85	DISEASES inferred ¹⁵
12	MPP3	Membrane Palmitoylated Protein 3	Protein Coding	14.83	DISEASES inferred ¹⁵
13	PIGT	Phosphatidylinositol Glycan Anchor Biosynthesis Class T	Protein Coding	14.77	DISEASES inferred ¹⁵

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Variations for Late-Onset Retinal Degeneration

UniProtKB/Swiss-Prot genetic disease variations for Late-Onset Retinal Degeneration:

⁷⁶

#	Symbol	AA change	Variation ID	SNP ID
1	C1QTNF5	p.Ser163Arg	VAR_032629	rs111033578

ClinVar genetic disease variations for Late-Onset Retinal Degeneration:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	C1QTNF5	NM_015645.4(C1QTNF5): c.489C> G (p.Ser163Arg)	single nucleotide variant	Likely pathogenic	rs111033578	GRCh37	Chromosome 11, 119210284: 119210284
2	C1QTNF5	NM_015645.4(C1QTNF5): c.489C> G (p.Ser163Arg)	single nucleotide variant	Likely pathogenic	rs111033578	GRCh38	Chromosome 11, 119339574: 119339574

Sources

Expression for Late-Onset Retinal Degeneration

Search GEO for disease gene expression data for Late-Onset Retinal Degeneration.

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Pathways for Late-Onset Retinal Degeneration

Pathways related to Late-Onset Retinal Degeneration according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Amino sugar and nucleotide sugar metabolism ³⁸ Show member pathways N-acetylglucosamine degradation I ¹ N-acetylglucosamine degradation II ¹ Synthesis of UDP-N-acetyl-glucosamine ⁶⁷ UDP-D-xylose and UDP-D-glucuronate biosynthesis ¹ UDP-N-acetyl-D-galactosamine biosynthesis II ¹ UDP-N-acetyl-D-glucosamine biosynthesis II ¹	10.51	HKDC1 NPL

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GO Terms for Late-Onset Retinal Degeneration

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Sources for Late-Onset Retinal Degeneration

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Late-Onset Retinal Degeneration (LORD)

Aliases & Classifications for Late-Onset Retinal Degeneration

MalaCards integrated aliases for Late-Onset Retinal Degeneration:

Characteristics:

Orphanet epidemiological data:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Late-Onset Retinal Degeneration

Related Diseases for Late-Onset Retinal Degeneration

Diseases in the Retinal Degeneration family:

Diseases related to Late-Onset Retinal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Late-Onset Retinal Degeneration:

Symptoms & Phenotypes for Late-Onset Retinal Degeneration

Human phenotypes related to Late-Onset Retinal Degeneration:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

GenomeRNAi Phenotypes related to Late-Onset Retinal Degeneration according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Late-Onset Retinal Degeneration

Drugs for Late-Onset Retinal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Late-Onset Retinal Degeneration

Genetic tests related to Late-Onset Retinal Degeneration:

Anatomical Context for Late-Onset Retinal Degeneration

MalaCards organs/tissues related to Late-Onset Retinal Degeneration:

Publications for Late-Onset Retinal Degeneration

Articles related to Late-Onset Retinal Degeneration:

Genes for Late-Onset Retinal Degeneration

Genes related to Late-Onset Retinal Degeneration (1 elite genes):

Variations for Late-Onset Retinal Degeneration

UniProtKB/Swiss-Prot genetic disease variations for Late-Onset Retinal Degeneration:

ClinVar genetic disease variations for Late-Onset Retinal Degeneration:

Expression for Late-Onset Retinal Degeneration

Pathways for Late-Onset Retinal Degeneration

Pathways related to Late-Onset Retinal Degeneration according to GeneCards Suite gene sharing:

GO Terms for Late-Onset Retinal Degeneration

Sources for Late-Onset Retinal Degeneration