Late Yaws disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

MalaCards based summary: Late Yaws, also known as yaws gummata and ulcers, is related to yaws and bejel. An important gene associated with Late Yaws is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Processing of Capped Intron-Containing Pre-mRNA. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Late Yaws

Diseases in the Yaws family:

Late Yaws

Early Yaws

Diseases related to Late Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	yaws	30.1	TPR PRCC
2	bejel	29.3	TPR PRCC
3	pinta disease	10.1
4	dupuytren contracture	9.9
5	3-methylglutaconic aciduria, type iii	9.9
6	syphilis	9.9
7	renal cell carcinoma, papillary, 1	9.5	TPR PRCC

Graphical network of the top 20 diseases related to Late Yaws:

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Symptoms & Phenotypes for Late Yaws

GenomeRNAi Phenotypes related to Late Yaws according to GeneCards Suite gene sharing:

²⁵ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-104	9.53	TPR
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.53	TPR
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.53	TPR
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.53	PRCC TPR
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-139	9.53	TPR
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-142	9.53	PRCC
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.53	PRCC
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-162	9.53	PRCC
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.53	PRCC
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.53	PRCC
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.53	PRCC
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-205	9.53	TPR
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	9.53	PRCC
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	9.53	TPR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.53	TPR
16	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.26	PRCC
17	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.26	PRCC
18	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.26	PRCC TPR

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Drugs & Therapeutics for Late Yaws

Search Clinical Trials, NIH Clinical Center for Late Yaws

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Genetic Tests for Late Yaws

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Anatomical Context for Late Yaws

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Publications for Late Yaws

Articles related to Late Yaws:

(show all 11)

#	Title	Authors	PMID	Year
1	Posterior segment changes secondary to late yaws. ⁶²	Sarangapani S...Benjamin L	11702987	2001
2	Late yaws and optic atrophy. ⁶²	Mohamed KN	2076042	1990
3	Occurrence of congenital, cardiovascular, visceral, neurologic, and neuro-ophthalmologic complications in late yaws: a theme for future research. ⁶²	Roman GC...Roman LN	3538316	1986
4	Plaque-host imbalance in severe periodontitis. A discussion based on two cases. ⁶²	Newman HN...Rule DC	6573340	1983
5	Late yaws: a case report. ⁶²	el Tonsy MH...Davidson JC	6927784	1982
6	Some problems of late yaws. ⁶²	Furtado T	4697342	1973
7	Neuro-ophthalmological study of late yaws. I. An introduction to yaws. ⁶²	Smith JL	5571036	1971
8	Neuro-ophthalmological study of late yaws and pinta. II. The Caracas project. ⁶²	Smith JL...Walter EK	4936861	1971
9	Late yaws. ⁶²	Fluker JL...Hewitt AB	5430349	1970
10	A neuro-ophthalmologic study of late yaws and pinta. ⁶²	Smith JL...Israel CW	5524209	1970
11	Late yaws and "dupuytren's contracture". ⁶²	MONEKOSSO GL	13936017	1963

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Genes for Late Yaws

Genes related to Late Yaws (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	6.13	DISEASES inferred ¹⁴
2	PRCC	Proline Rich Mitotic Checkpoint Control Factor	Protein Coding	5.96	DISEASES inferred ¹⁴

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Variations for Late Yaws

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Expression for Late Yaws

Search GEO for disease gene expression data for Late Yaws.

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Pathways for Late Yaws

Pathways related to Late Yaws according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Processing of Capped Intron-Containing Pre-mRNA ⁶⁶ Show member pathways Metabolism of RNA ⁶⁶ mRNA processing ⁷⁴ mRNA Splicing ⁶⁶ mRNA Splicing - Major Pathway ⁶⁶	11.81	TPR PRCC

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GO Terms for Late Yaws

Biological processes related to Late Yaws according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle	GO:0007049	8.8	TPR PRCC

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Sources for Late Yaws

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LTY001 MIFTS: 19	Late Yaws Categories: Bone diseases, Infectious diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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