MCID: LTY001
MIFTS: 19

Late Yaws

Categories: Bone diseases, Infectious diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Late Yaws

MalaCards integrated aliases for Late Yaws:

Name: Late Yaws 11 14 71
Yaws Gummata and Ulcers 11 71
Multiple Papillomata Due to Yaws and Wet Crab Yaws 11
Gummata and Ulcers Due to Yaws 11
Gummatous Frambeside 11
Nodular Late Yaws 11
Gummata of Yaws 11
Ulcers of Yaws 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10567
ICD9CM 34 102.1 102.4
NCIt 49 C41354
SNOMED-CT 68 186968004
ICD10 31 A66.1 A66.4
UMLS 71 C0153234 C0276007 C1517744

Summaries for Late Yaws

Disease Ontology: 11 A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

MalaCards based summary: Late Yaws, also known as yaws gummata and ulcers, is related to yaws and bejel. An important gene associated with Late Yaws is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Processing of Capped Intron-Containing Pre-mRNA. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Late Yaws

Diseases in the Yaws family:

Late Yaws Early Yaws

Diseases related to Late Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 yaws 30.1 TPR PRCC
2 bejel 29.3 TPR PRCC
3 pinta disease 10.1
4 dupuytren contracture 9.9
5 3-methylglutaconic aciduria, type iii 9.9
6 syphilis 9.9
7 renal cell carcinoma, papillary, 1 9.5 TPR PRCC

Graphical network of the top 20 diseases related to Late Yaws:



Diseases related to Late Yaws

Symptoms & Phenotypes for Late Yaws

GenomeRNAi Phenotypes related to Late Yaws according to GeneCards Suite gene sharing:

25 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.53 TPR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 TPR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.53 TPR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.53 PRCC TPR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.53 TPR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.53 PRCC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.53 PRCC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.53 PRCC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.53 PRCC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 PRCC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.53 PRCC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 TPR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.53 PRCC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.53 TPR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.53 TPR
16 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.26 PRCC
17 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.26 PRCC
18 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.26 PRCC TPR

Drugs & Therapeutics for Late Yaws

Search Clinical Trials, NIH Clinical Center for Late Yaws

Genetic Tests for Late Yaws

Anatomical Context for Late Yaws

Publications for Late Yaws

Articles related to Late Yaws:

(show all 11)
# Title Authors PMID Year
1
Posterior segment changes secondary to late yaws. 62
11702987 2001
2
Late yaws and optic atrophy. 62
2076042 1990
3
Occurrence of congenital, cardiovascular, visceral, neurologic, and neuro-ophthalmologic complications in late yaws: a theme for future research. 62
3538316 1986
4
Plaque-host imbalance in severe periodontitis. A discussion based on two cases. 62
6573340 1983
5
Late yaws: a case report. 62
6927784 1982
6
Some problems of late yaws. 62
4697342 1973
7
Neuro-ophthalmological study of late yaws. I. An introduction to yaws. 62
5571036 1971
8
Neuro-ophthalmological study of late yaws and pinta. II. The Caracas project. 62
4936861 1971
9
Late yaws. 62
5430349 1970
10
A neuro-ophthalmologic study of late yaws and pinta. 62
5524209 1970
11
Late yaws and "dupuytren's contracture". 62
13936017 1963

Variations for Late Yaws

Expression for Late Yaws

Search GEO for disease gene expression data for Late Yaws.

Pathways for Late Yaws

Pathways related to Late Yaws according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 TPR PRCC

GO Terms for Late Yaws

Biological processes related to Late Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 8.8 TPR PRCC

Sources for Late Yaws

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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