Aliases & Classifications for Latent Syphilis

MalaCards integrated aliases for Latent Syphilis:

Name: Latent Syphilis 12 15 17
Syphilis, Latent 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9531
ICD9CM 34 097.1
MeSH 44 D013592
NCIt 50 C35056
SNOMED-CT 67 444150000
ICD10 32 A53.0
UMLS 70 C0039133

Summaries for Latent Syphilis

Disease Ontology : 12 A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease.

MalaCards based summary : Latent Syphilis, also known as syphilis, latent, is related to asymptomatic neurosyphilis and congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Latent Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Penicillin G and Penicillin G Procaine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, eye and bone marrow.

Related Diseases for Latent Syphilis

Diseases related to Latent Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.0 CXCL13 CD4
2 congenital syphilis 31.8 TPR POLA1 CD4
3 syphilis 31.7 TPR POLA1 CD8A CD4
4 iritis 30.0 CD8A CD4
5 chorioretinitis 30.0 CD8A CD4
6 primary syphilis 29.2 TPR POLA1 PDE6D CD8A CD4
7 secondary syphilis 29.2 TPR POLA1 CXCL13 CD8A CD4
8 neurosyphilis 10.5
9 yaws 10.3 TPR POLA1
10 early congenital syphilis 10.3 TPR POLA1
11 cork-handlers' disease 10.2 CD8A CD4
12 necrotic uveal melanoma 10.2 CD8A CD4
13 ventilation pneumonitis 10.2 CD8A CD4
14 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
15 type 1 diabetes mellitus 23 10.2 CD8A CD4
16 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
17 parapsoriasis 10.2 CD8A CD4
18 gastroduodenitis 10.2 CD8A CD4
19 duodenitis 10.2 CD8A CD4
20 norwegian scabies 10.2 CD8A CD4
21 bird fancier's lung 10.2 CD8A CD4
22 skin sarcoidosis 10.2 CD8A CD4
23 metal allergy 10.2 CD8A CD4
24 variola major 10.2 CD8A CD4
25 follicular mucinosis 10.2 CD8A CD4
26 spongiotic dermatitis 10.2 CD8A CD4
27 acute retinal necrosis syndrome 10.2 CD8A CD4
28 cerebral lymphoma 10.2 CD8A CD4
29 oral tuberculosis 10.2 CD8A CD4
30 cerebritis 10.2 CD8A CD4
31 invasive malignant thymoma 10.2 CD8A CD4
32 west nile encephalitis 10.2 CD8A CD4
33 granulomatous hepatitis 10.2 CD8A CD4
34 exanthem 10.2 CD8A CD4
35 exanthema subitum 10.2 CD8A CD4
36 immunodeficiency 36 10.2 CD8A CD4
37 viral exanthem 10.2 CD8A CD4
38 glanders 10.2 CD8A CD4
39 oral hairy leukoplakia 10.2 CD8A CD4
40 superficial basal cell carcinoma 10.2 CD8A CD4
41 esophageal candidiasis 10.2 CD8A CD4
42 parotid disease 10.2 CD8A CD4
43 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.2 CD8A CD4
44 ulcerative stomatitis 10.2 CD8A CD4
45 granulomatous dermatitis 10.2 CD8A CD4
46 west nile fever 10.2 CD8A CD4
47 neurosarcoidosis 10.2 CD8A CD4
48 retinitis pigmentosa 46 10.2 CD8A CD4
49 pneumonic tularemia 10.2 CD8A CD4
50 tularemia 10.2 CD8A CD4

Comorbidity relations with Latent Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Hypertension, Essential
Neurosyphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Latent Syphilis:



Diseases related to Latent Syphilis

Symptoms & Phenotypes for Latent Syphilis

UMLS symptoms related to Latent Syphilis:


syphilitic chancre

Drugs & Therapeutics for Latent Syphilis

Drugs for Latent Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved 61-33-6 5904
2 Penicillin G Procaine
3 Penicillin G Benzathine
4 penicillins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Do Low Serum Penicillin Levels Correlate With Treatment Failure? Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Latent Syphilis

Cochrane evidence based reviews: syphilis, latent

Genetic Tests for Latent Syphilis

Anatomical Context for Latent Syphilis

MalaCards organs/tissues related to Latent Syphilis:

40
Whole Blood, Eye, Bone Marrow, Lymph Node, Pituitary

Publications for Latent Syphilis

Articles related to Latent Syphilis:

(show top 50) (show all 540)
# Title Authors PMID Year
1
A Failure of Rapid Drug Desensitization. 61
33748854 2021
2
Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis. 61
33782148 2021
3
High-risk sexual behavior and HIV/STDs cascade of care in migrants: results from an Italian dedicated outpatient clinic. 61
33690214 2021
4
MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in Peripheral Blood Mononuclear Cells May Serve as Novel Biomarkers for Syphilis Diagnosis. 61
33524569 2021
5
An unusual case of oral condyloma lata. 61
33607303 2021
6
Nodular syphilitic scleritis: a rare and forgotten entity. 61
33599170 2021
7
Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses. 61
33608479 2021
8
Syphilis infection and epidemiological characteristics in Haidian District, Beijing, China, 2013-2018. 61
33360028 2021
9
Efficacy of minocycline in the treatment of early syphilis. 61
33496202 2021
10
Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania. 61
33276749 2020
11
Prevalence of latent tuberculosis infection, hepatitis B, hepatitis C, and syphilis among newly arrived unaccompanied minors living in reception centers in Rome. 61
32947054 2020
12
Epidemiology of sexually transmitted infections among female sex workers in Switzerland: a local, exploratory, cross-sectional study. 61
33378545 2020
13
Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis. 61
33298143 2020
14
Annular and arciform lesions of the palms as unique manifestations of secondary syphilis. 61
32981425 2020
15
Don't forget syphilis in membranous nephropathy before immunosuppressants: Latent syphilis in a patient with proteinuria. 61
32144011 2020
16
Deciphering the serological response to syphilis treatment in men living with HIV. 61
32773482 2020
17
A new specimen for syphilis diagnosis: Evidence by high loads of Treponema pallidum DNA in saliva. 61
33099614 2020
18
Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients. 61
33026095 2020
19
Elevation of Cerebrospinal Fluid Light and Heavy Neurofilament Levels in Symptomatic Neurosyphilis. 61
32649582 2020
20
The wrong Spirochaete? Acute kidney injury in a returning traveller with syphilis - a case report. 61
32957955 2020
21
[Epidemiology of syphilis in Zhejiang province, 2010-2019]. 61
32867442 2020
22
Differential Serodiagnostics of Latent Stages of Syphilis Based on Measuring IgG and IgM Levels towards Extended Panel of Recombinant Antigens of T. pallidum. 61
32910381 2020
23
Retrospective comparison between non-treponemal and treponemal tests for screening of blood donors for syphilis and their correlation with donor history in a tertiary care teaching hospital. 61
32444281 2020
24
Utility of rapid plasmin reagin titres in assessing treatment response and re-infection for infectious syphilis. 61
32687780 2020
25
Human Immunodeficiency Virus-infected men who have sex with men with syphilis: A 5-year multicentre study in Malaysia. 61
32723993 2020
26
The Potential Clinical Benefit of Tocilizumab Therapy for Patients with HHV-8-infected AIDS-related Multicentric Castleman Disease: A Case Report and Literature Review. 61
32399323 2020
27
Case report of eight pregnant women with syphilis. 61
31740278 2020
28
Acquired syphilis in children: A retrospective study over two-and-a-half decades in a tertiary care center in northern India. 61
31994211 2020
29
Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: Case report
. 61
31813414 2020
30
Membranous Glomerulonephritis as an Uncommon Presentation of Secondary Syphilis: A Reminder on Therapeutic Decision-Making in Clinical Practice. 61
33078640 2020
31
[Rapidly progressive dementia due to neurosyphilis (general paralysis). A treatable case of dementia]. 61
32841147 2020
32
CXCL13 concentration in latent syphilis patients with treatment failure. 61
33336020 2020
33
A Nationwide Spatiotemporal Analysis of Syphilis Over 21 Years and Implications for Prevention and Control in China. 61
31237616 2020
34
Differences in maternal characteristics and pregnancy outcomes between syphilitic women with and without partner coinfection. 61
31771540 2019
35
Treponema pallidum-specific immune responses and autoimmunity in patients who remain serofast after treatment of syphilis. 61
31839781 2019
36
Treponema pallidum Nucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men. 61
31189578 2019
37
Early syphilis: risk factors and clinical manifestations focusing on HIV-positive patients. 61
31420018 2019
38
A case report of HIV-1 superinfection in an HIV controller leading to loss of viremia control: a retrospective of 10 years of follow-up. 61
31277590 2019
39
Comparative Performance of the Reverse Algorithm Using Architect Syphilis TP Versus the Traditional Algorithm Using Rapid Plasma Reagin in Florida's Public Health Testing Population. 61
30809986 2019
40
Otosyphilis: Resurgence of an Old Disease. 61
30592050 2019
41
Syphilis. 61
30738716 2019
42
[SOME PECULIARITIES OF SYPHILIS MORPHOLOGY AND PATHOLOGY (REVIEW)]. 61
31101787 2019
43
Mathematical Assessment of the Role of Early Latent Infections and Targeted Control Strategies on Syphilis Transmission Dynamics. 61
29971669 2019
44
Post-bacterial infection chronic fatigue syndrome is not a latent infection. 61
30722945 2019
45
Men treated for syphilis in Białystok, Poland,2014-2018 61
31766830 2019
46
[Diagnostic imminoarray assay for characterization of immunoglobulin igg and igm level in syphilis patients serum towards 12 recombinant antigens of t. pallidum before and after the therapy.] 61
31610107 2019
47
Natural experiment of syphilis treatment with doxycycline or benzathine penicillin in HIV-infected patients. 61
30102654 2019
48
A Novel Nested Real-time Polymerase Chain Reaction for Treponema pallidum DNA in Syphilis Biospecimens. 61
30247262 2019
49
Clinical factors associated with syphilis concordance in men in sexual partnerships: a cross-sectional couples study. 61
29191816 2018
50
Acute subretinal abscess in Staphylococcus aureus septicaemia with endophthalmitis showcased by multimodal retinal imaging and with 2-year follow-up. 61
30567135 2018

Variations for Latent Syphilis

Expression for Latent Syphilis

Search GEO for disease gene expression data for Latent Syphilis.

Pathways for Latent Syphilis

Pathways related to Latent Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 CD8A CD4

GO Terms for Latent Syphilis

Biological processes related to Latent Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.43 CXCL13 CD8A CD4
2 T cell activation GO:0042110 9.16 CD8A CD4
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 FES CD8A CD4
4 positive regulation of monocyte differentiation GO:0045657 8.62 FES CD4

Molecular functions related to Latent Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Latent Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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