Aliases & Classifications for Latent Syphilis

MalaCards integrated aliases for Latent Syphilis:

Name: Latent Syphilis 12 15
Syphilis, Latent 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9531
ICD10 33 A53.0
ICD9CM 35 097.1
MeSH 44 D013592
NCIt 50 C35056
SNOMED-CT 68 186906003 444150000
UMLS 73 C0039133

Summaries for Latent Syphilis

Disease Ontology : 12 A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease.

MalaCards based summary : Latent Syphilis, also known as syphilis, latent, is related to asymptomatic neurosyphilis and chorioretinitis, and has symptoms including syphilitic chancre An important gene associated with Latent Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotype is G0/1 arrest.

Related Diseases for Latent Syphilis

Diseases related to Latent Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 30.7 CD40LG DDX41 EXTL3 MYH9
2 chorioretinitis 29.7 CD40LG EXTL3
3 congenital syphilis 29.2 CD40LG DDX41 EXTL3 MYH9 POLA1
4 syphilis 28.4 CD40LG DDX41 EXTL3 MYH9 POLA1 TPR
5 late congenital syphilis 10.2 DDX41 EXTL3
6 early yaws 10.2 CD40LG EXTL3
7 syphilitic meningitis 10.2 CD40LG EXTL3
8 early congenital syphilis 10.2 CD40LG MYH9
9 optic papillitis 10.2 CD40LG EXTL3
10 urethritis 10.1 CD40LG EXTL3
11 neurosyphilis 10.1
12 thrombocytopenia due to platelet alloimmunization 10.1 CD40LG MYH9
13 cardiovascular syphilis 10.1 CD40LG DDX41
14 tabes dorsalis 10.1 DDX41 EXTL3
15 focal chorioretinitis 10.1 CD40LG DDX41
16 neuroretinitis 10.0 CD40LG EXTL3
17 primary thrombocytopenia 10.0 CD40LG MYH9
18 immunodeficiency 17 9.9 CD40LG DDX41
19 hemorrhagic disease 9.9 CD40LG MYH9
20 yaws 9.8 EXTL3 TPR
21 blood platelet disease 9.8 CD40LG MYH9
22 aging 9.7
23 glomerulonephritis 9.7
24 penicillin allergy 9.7
25 osteomyelitis 9.7
26 tuberculoid leprosy 9.7
27 scleritis 9.7
28 hemoglobinuria 9.7
29 bowen's disease 9.7
30 paroxysmal cold hemoglobinuria 9.7
31 primary bacterial infectious disease 9.6 CD40LG DDX41 EXTL3
32 hypersensitivity reaction disease 9.6 CD40LG DDX41
33 immune system disease 9.3 CD40LG DDX41
34 tertiary syphilis 9.1 CD40LG DDX41 EXTL3 MYH9
35 tertiary neurosyphilis 9.1 CD40LG DDX41 EXTL3 MYH9
36 primary syphilis 9.0 CD40LG EXTL3 MYH9 POLA1
37 secondary syphilis 7.9 CD40LG DDX41 EXTL3 POLA1 TPR

Comorbidity relations with Latent Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Hypertension, Essential
Neurosyphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Latent Syphilis:



Diseases related to Latent Syphilis

Symptoms & Phenotypes for Latent Syphilis

UMLS symptoms related to Latent Syphilis:


syphilitic chancre

GenomeRNAi Phenotypes related to Latent Syphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 8.8 POLA1 TPR DDX41

Drugs & Therapeutics for Latent Syphilis

Drugs for Latent Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
3 penicillins Phase 4,Phase 3
4 Penicillin G Benzathine Phase 4,Phase 3
5 Penicillin G Procaine Phase 4,Phase 3
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3
8
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
9
Azithromycin Approved Phase 3 83905-01-5 55185 447043
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Antimalarials Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
3 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
4 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Latent Syphilis

Cochrane evidence based reviews: syphilis, latent

Genetic Tests for Latent Syphilis

Anatomical Context for Latent Syphilis

MalaCards organs/tissues related to Latent Syphilis:

41
Testes

Publications for Latent Syphilis

Articles related to Latent Syphilis:

(show top 50) (show all 88)
# Title Authors Year
1
Untreated Late Latent Syphilis of Both Spouses with Observation of Kassowitz Law: Adverse Pregnancy Outcomes in the Postpenicillin Era. ( 28400651 )
2017
2
Molecular Subtyping and Surveillance of Resistance Genes In Treponema pallidum DNA From Patients With Secondary and Latent Syphilis in Hunan, China. ( 27100768 )
2016
3
Recurrent Jarisch-Herxheimer reaction in late latent syphilis. ( 26834029 )
2016
4
Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention. ( 26660338 )
2016
5
Unilateral Nodular Scleritis Secondary to Latent Syphilis. ( 26056375 )
2015
6
Latent syphilis among inpatients in an urban area of China. ( 25948433 )
2015
7
Detection of Treponema pallidum by semi-nested PCR in the cerebrospinal fluid of asymptomatic HIV-infected patients with latent syphilis. ( 25651740 )
2014
8
Late latent syphilis in a patient with end-stage renal disease and presumptive penicillin allergy. ( 24644115 )
2014
9
Late latent syphilis in two hemodialysis units. ( 23354207 )
2013
10
Characteristics of patients with primary and late latent syphilis patients who were initially non-reactive to the rapid plasma reagin test. ( 23429083 )
2013
11
Cerebrospinal Fluid Abnormalities in HIV-Negative Patients with Secondary and Early Latent Syphilis and Serum VDRL a8Y 1:32. ( 23919017 )
2013
12
Impact of reverse sequence syphilis screening on new diagnoses of late latent syphilis in Edmonton, Canada. ( 22706214 )
2012
13
Perinatal outcome in cases of latent syphilis during pregnancy. ( 22503519 )
2012
14
Osteomyelitis as the only manifestation of late latent syphilis: case report and literature review. ( 21680676 )
2011
15
Variations in the epidemiology of primary, secondary and early latent syphilis, England and Wales: 1999 to 2008. ( 21262786 )
2011
16
Is it useful to perform a chest X-ray in asymptomatic patients with late latent syphilis? ( 21427433 )
2011
17
Usefulness of routine lumbar puncture in non-HIV patients with latent syphilis of unknown duration. ( 19837729 )
2010
18
Pre-treatment syphilis titers: distribution and evaluation of their use to distinguish early from late latent syphilis and to prioritize contact investigations. ( 19773682 )
2009
19
Acute syphilitic posterior placoid chorioretinitis in late latent syphilis. ( 19255274 )
2009
20
Characteristics of primary and late latent syphilis cases which were initially non-reactive with the rapid plasma reagin as the screening test. ( 18574118 )
2008
21
Postoperative inflammation as the presenting sign of latent syphilis. ( 18569802 )
2008
22
The outcome of treatment of early latent syphilis and syphilis with undetermined duration in HIV-infected and HIV-uninfected patients. ( 18073011 )
2007
23
Detection of Treponema pallidum sp pallidum DNA in latent syphilis. ( 18073019 )
2007
24
Detection of treponema pallidum DNA in the serum of an adequately treated patient with latent syphilis. ( 17598051 )
2007
25
Neurosyphilis is unlikely in patients with late latent syphilis and a negative blood VDRL-test. ( 16874420 )
2006
26
Latent syphilis confirmed by polymerase chain reaction in 2 HIV-positive patients with inconclusive serologic test results. ( 16172324 )
2005
27
Treatment of latent syphilis in HIV-infected patients with 10 d of benzylpenicillin G benethamine: a prospective study in Maputo, Mozambique. ( 12064687 )
2002
28
Lumbar puncture for evaluation of latent syphilis in hospitalized patients. High prevalence of cerebrospinal fluid abnormalities unrelated to syphilis. ( 7618990 )
1995
29
Photo quiz. Paroxysmal cold hemoglobinuria secondary to latent syphilis of unknown duration. ( 7742422 )
1995
30
Multiple unilateral reddish tumors on the ear and forehead in a woman with early syphilis. Angiolymphoid hyperplasia (ALHE) with eosinophilia coexisting with early latent syphilis. ( 8129421 )
1994
31
Comparison of early and late latent syphilis--Colorado, 1991. ( 8437546 )
1993
32
Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis. ( 8108759 )
1993
33
Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus. ( 1442850 )
1992
34
Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis. ( 1626576 )
1992
35
The variety of clinical and histopathologic presentations of glomerulonephritis associated with latent syphilis. ( 1459832 )
1992
36
Treatment of secondary recurrent and early latent syphilis with penicillin and ethamide: clinical and experimental evaluation. ( 3678547 )
1987
37
Treatment of early latent syphilis under 1 year's duration: serologic response to treatment of 368 patients. ( 3782528 )
1986
38
Neurosyphilis after treatment of latent syphilis with benzathine penicillin. ( 3721511 )
1986
39
Penetration of penicillin into the cerebrospinal fluid of patients with latent syphilis. ( 7323106 )
1981
40
Cerebrospinal fluid penicillin levels during therapy for latent syphilis. ( 7299984 )
1981
41
Reinfection primary, secondary, and latent syphilis: the serologic response after treatment. ( 7444709 )
1980
42
Serologic responses to treatment of 128 patients with late latent syphilis. ( 531723 )
1979
43
Treatment of early latent syphilis of less than a year's duration: an evaluation of 275 cases. ( 725706 )
1978
44
Treatment of latent syphilis. ( 1010779 )
1976
45
The diagnosis and treatment of infectious and latent syphilis. ( 4559748 )
1972
46
Latent syphilis--nomenclature of its stages. ( 5068690 )
1972
47
Latent syphilis: immunoglobulins reactive in immunofluorescence and other serological tests. ( 16558017 )
1971
48
A graphic guide for clinical management of latent syphilis. ( 5426893 )
1970
49
A graphic guide for clinical management of latent syphilis. ( 5427706 )
1970
50
A graphic guide for clinical management of latent syphilis. ( 4924873 )
1970

Variations for Latent Syphilis

Expression for Latent Syphilis

Search GEO for disease gene expression data for Latent Syphilis.

Pathways for Latent Syphilis

GO Terms for Latent Syphilis

Molecular functions related to Latent Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Latent Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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