Aliases & Classifications for Latent Syphilis

MalaCards integrated aliases for Latent Syphilis:

Name: Latent Syphilis 12 15
Syphilis, Latent 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9531
ICD10 33 A53.0
ICD9CM 35 097.1
MeSH 44 D013592
NCIt 50 C35056
UMLS 73 C0039133

Summaries for Latent Syphilis

Disease Ontology : 12 A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease.

MalaCards based summary : Latent Syphilis, also known as syphilis, latent, is related to asymptomatic neurosyphilis and syphilis, and has symptoms including syphilitic chancre An important gene associated with Latent Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Latent Syphilis

Graphical network of the top 20 diseases related to Latent Syphilis:



Diseases related to Latent Syphilis

Symptoms & Phenotypes for Latent Syphilis

UMLS symptoms related to Latent Syphilis:


syphilitic chancre

GenomeRNAi Phenotypes related to Latent Syphilis according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.85 PDE6D
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.85 DDX41 PDE6D
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.85 PDE6D
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.85 DDX41
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.85 DDX41
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.85 PDE6D
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.85 PDE6D
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.85 PDE6D
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.85 PDE6D
10 G0/1 arrest GR00098-A-2 9.13 DDX41 POLA1 TPR
11 Increased G2M DNA content, increased 8N DNA content GR00098-A-1 8.92 DDX41 EXTL3 POLA1 TPR

Drugs & Therapeutics for Latent Syphilis

Drugs for Latent Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
3 Penicillin G Benzathine Phase 4,Phase 3
4 penicillins Phase 4,Phase 3
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Anti-Infective Agents Phase 4,Phase 3
7 Penicillin G Procaine Phase 4,Phase 3
8
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
9
Azithromycin Approved Phase 3 83905-01-5 55185 447043
10 Antiprotozoal Agents Phase 3
11 Antiparasitic Agents Phase 3
12 Antimalarials Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
3 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
4 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Latent Syphilis

Cochrane evidence based reviews: syphilis, latent

Genetic Tests for Latent Syphilis

Anatomical Context for Latent Syphilis

MalaCards organs/tissues related to Latent Syphilis:

41
Testes

Publications for Latent Syphilis

Articles related to Latent Syphilis:

(show top 50) (show all 94)
# Title Authors Year
1
Latent Syphilis Infection in Pregnancy: An Ultrasound Diagnosed Case of Penicillin Treatment Failure. ( 30147973 )
2018
2
Untreated Late Latent Syphilis of Both Spouses with Observation of Kassowitz Law: Adverse Pregnancy Outcomes in the Postpenicillin Era. ( 28400651 )
2017
3
Molecular Subtyping and Surveillance of Resistance Genes In Treponema pallidum DNA From Patients With Secondary and Latent Syphilis in Hunan, China. ( 27100768 )
2016
4
Recurrent Jarisch-Herxheimer reaction in late latent syphilis. ( 26834029 )
2016
5
Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention. ( 26660338 )
2016
6
Unilateral Nodular Scleritis Secondary to Latent Syphilis. ( 26056375 )
2015
7
Latent syphilis among inpatients in an urban area of China. ( 25948433 )
2015
8
Detection of Treponema pallidum by semi-nested PCR in the cerebrospinal fluid of asymptomatic HIV-infected patients with latent syphilis. ( 25651740 )
2014
9
Late latent syphilis in a patient with end-stage renal disease and presumptive penicillin allergy. ( 24644115 )
2014
10
Late latent syphilis in two hemodialysis units. ( 23354207 )
2013
11
Characteristics of patients with primary and late latent syphilis patients who were initially non-reactive to the rapid plasma reagin test. ( 23429083 )
2013
12
Cerebrospinal Fluid Abnormalities in HIV-Negative Patients with Secondary and Early Latent Syphilis and Serum VDRL a8Y 1:32. ( 23919017 )
2013
13
Impact of reverse sequence syphilis screening on new diagnoses of late latent syphilis in Edmonton, Canada. ( 22706214 )
2012
14
Perinatal outcome in cases of latent syphilis during pregnancy. ( 22503519 )
2012
15
Osteomyelitis as the only manifestation of late latent syphilis: case report and literature review. ( 21680676 )
2011
16
Variations in the epidemiology of primary, secondary and early latent syphilis, England and Wales: 1999 to 2008. ( 21262786 )
2011
17
Is it useful to perform a chest X-ray in asymptomatic patients with late latent syphilis? ( 21427433 )
2011
18
Usefulness of routine lumbar puncture in non-HIV patients with latent syphilis of unknown duration. ( 19837729 )
2010
19
Pre-treatment syphilis titers: distribution and evaluation of their use to distinguish early from late latent syphilis and to prioritize contact investigations. ( 19773682 )
2009
20
Acute syphilitic posterior placoid chorioretinitis in late latent syphilis. ( 19255274 )
2009
21
Characteristics of primary and late latent syphilis cases which were initially non-reactive with the rapid plasma reagin as the screening test. ( 18574118 )
2008
22
Postoperative inflammation as the presenting sign of latent syphilis. ( 18569802 )
2008
23
The outcome of treatment of early latent syphilis and syphilis with undetermined duration in HIV-infected and HIV-uninfected patients. ( 18073011 )
2007
24
Detection of Treponema pallidum sp pallidum DNA in latent syphilis. ( 18073019 )
2007
25
Detection of treponema pallidum DNA in the serum of an adequately treated patient with latent syphilis. ( 17598051 )
2007
26
Neurosyphilis is unlikely in patients with late latent syphilis and a negative blood VDRL-test. ( 16874420 )
2006
27
Latent syphilis confirmed by polymerase chain reaction in 2 HIV-positive patients with inconclusive serologic test results. ( 16172324 )
2005
28
Treatment of latent syphilis in HIV-infected patients with 10 d of benzylpenicillin G benethamine: a prospective study in Maputo, Mozambique. ( 12064687 )
2002
29
Lumbar puncture for evaluation of latent syphilis in hospitalized patients. High prevalence of cerebrospinal fluid abnormalities unrelated to syphilis. ( 7618990 )
1995
30
Photo quiz. Paroxysmal cold hemoglobinuria secondary to latent syphilis of unknown duration. ( 7742422 )
1995
31
Multiple unilateral reddish tumors on the ear and forehead in a woman with early syphilis. Angiolymphoid hyperplasia (ALHE) with eosinophilia coexisting with early latent syphilis. ( 8129421 )
1994
32
Comparison of early and late latent syphilis--Colorado, 1991. ( 8437546 )
1993
33
Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis. ( 8108759 )
1993
34
Comparison of Early and Late Latent Syphilis- Colorado, 1991. ( 27082042 )
1993
35
Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus. ( 1442850 )
1992
36
Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis. ( 1626576 )
1992
37
The variety of clinical and histopathologic presentations of glomerulonephritis associated with latent syphilis. ( 1459832 )
1992
38
Treatment of secondary recurrent and early latent syphilis with penicillin and ethamide: clinical and experimental evaluation. ( 3678547 )
1987
39
Treatment of early latent syphilis under 1 year's duration: serologic response to treatment of 368 patients. ( 3782528 )
1986
40
Neurosyphilis after treatment of latent syphilis with benzathine penicillin. ( 3721511 )
1986
41
Penetration of penicillin into the cerebrospinal fluid of patients with latent syphilis. ( 7323106 )
1981
42
Cerebrospinal fluid penicillin levels during therapy for latent syphilis. ( 7299984 )
1981
43
Reinfection primary, secondary, and latent syphilis: the serologic response after treatment. ( 7444709 )
1980
44
Serologic responses to treatment of 128 patients with late latent syphilis. ( 531723 )
1979
45
Treatment of early latent syphilis of less than a year's duration: an evaluation of 275 cases. ( 725706 )
1978
46
Treatment of latent syphilis. ( 1010779 )
1976
47
The diagnosis and treatment of infectious and latent syphilis. ( 4559748 )
1972
48
Latent syphilis--nomenclature of its stages. ( 5068690 )
1972
49
Latent syphilis: immunoglobulins reactive in immunofluorescence and other serological tests. ( 16558017 )
1971
50
A graphic guide for clinical management of latent syphilis. ( 5426893 )
1970

Variations for Latent Syphilis

Expression for Latent Syphilis

Search GEO for disease gene expression data for Latent Syphilis.

Pathways for Latent Syphilis

GO Terms for Latent Syphilis

Molecular functions related to Latent Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Latent Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....