MCID: LTN001
MIFTS: 34

Latent Syphilis

Categories: Infectious diseases
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Aliases & Classifications for Latent Syphilis

MalaCards integrated aliases for Latent Syphilis:

Name: Latent Syphilis 11 14 16
Syphilis, Latent 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:9531
ICD9CM 34 097.1
MeSH 43 D013592
NCIt 49 C35056
SNOMED-CT 68 444150000
ICD10 31 A53.0
UMLS 71 C0039133

Summaries for Latent Syphilis

Disease Ontology: 11 A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease.

MalaCards based summary: Latent Syphilis, also known as syphilis, latent, is related to asymptomatic neurosyphilis and tuberculoid leprosy, and has symptoms including syphilitic chancre An important gene associated with Latent Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways are Th2 Differentiation and Cytokines and inflammatory response. The drugs Linezolid and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and bone marrow.

Related Diseases for Latent Syphilis

Diseases related to Latent Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.0 CXCL13 CD4
2 tuberculoid leprosy 30.0 IFNG CD4
3 choroiditis 30.0 IFNG CD4
4 chorioretinitis 30.0 IFNG CD4
5 congenital syphilis 29.9 TPR POLA1 CD4
6 anterior uveitis 29.9 IFNG CD4
7 secondary syphilis 29.5 TPR POLA1 MIR589 CXCL13 CD4
8 primary syphilis 29.1 TPR POLA1 PDE6D MIR6511A1 MIR589 CD4
9 syphilis 11.4
10 neurosyphilis 10.5
11 early yaws 10.3 TPR CD4
12 gummatous syphilis 10.3 TPR CD4
13 yaws 10.3 TPR POLA1
14 early congenital syphilis 10.2 TPR POLA1
15 syphilitic meningitis 10.2 CXCL13 CD4
16 panophthalmitis 10.2 IFNG CD4
17 ocular tuberculosis 10.2 IFNG CD4
18 pericardial tuberculosis 10.2 IFNG CD4
19 suppurative lymphadenitis 10.2 IFNG CD4
20 urogenital tuberculosis 10.2 IFNG CD4
21 necrotizing ulcerative gingivitis 10.2 IFNG CD4
22 epidural abscess 10.1 IFNG CD4
23 penicilliosis 10.1 IFNG CD4
24 neuroretinitis 10.1 IFNG CD4
25 lymph node tuberculosis 10.1 IFNG CD4
26 arachnoiditis 10.1 IFNG CD4
27 viral exanthem 10.1 IFNG CD4
28 skin sarcoidosis 10.1 IFNG CD4
29 intestinal tuberculosis 10.1 IFNG CD4
30 gastrointestinal tuberculosis 10.1 IFNG CD4
31 central nervous system tuberculosis 10.1 IFNG CD4
32 abdominal tuberculosis 10.1 IFNG CD4
33 cervical adenitis 10.1 IFNG CD4
34 mycoplasma pneumoniae pneumonia 10.1 IFNG CD4
35 chondromalacia 10.1 IFNG CD4
36 berylliosis 10.1 IFNG CD4
37 lung abscess 10.1 IFNG CD4
38 miliary tuberculosis 10.1 IFNG CD4
39 aortitis 10.1 IFNG CD4
40 scleral disease 10.1 IFNG CD4
41 relapsing polychondritis 10.1 IFNG CD4
42 congenital toxoplasmosis 10.1 IFNG CD4
43 sporotrichosis 10.1 IFNG CD4
44 polyclonal hypergammaglobulinemia 10.1 CXCL13 CD4
45 multidrug-resistant tuberculosis 10.1 IFNG CD4
46 fungal meningitis 10.1 IFNG CD4
47 macs syndrome 10.1 IFNG CD4
48 intermediate uveitis 10.1 IFNG CD4
49 strongyloidiasis 10.1 IFNG CD4
50 cryptococcal meningitis 10.1 IFNG CD4

Comorbidity relations with Latent Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease, Familial, 1
Decubitus Ulcer Deficiency Anemia
Heart Disease Hypertension, Essential
Neurosyphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Latent Syphilis:



Diseases related to Latent Syphilis

Symptoms & Phenotypes for Latent Syphilis

UMLS symptoms related to Latent Syphilis:


syphilitic chancre

Drugs & Therapeutics for Latent Syphilis

Drugs for Latent Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
2 Antibiotics, Antitubercular Phase 3
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5
Benzylpenicillin Approved, Vet_approved 61-33-6 5904
6 Penicillins
7 Penicillin G Procaine
8 Penicillin G Benzathine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Oral and Neuro-Penetrative Alternative Antibiotics for Patients With Syphilis Recruiting NCT05069974 Phase 3 Linezolid;Benzathine Penicilllin G
2 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Do Low Serum Penicillin Levels Correlate With Treatment Failure? Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Latent Syphilis

Cochrane evidence based reviews: syphilis, latent

Genetic Tests for Latent Syphilis

Anatomical Context for Latent Syphilis

Organs/tissues related to Latent Syphilis:

MalaCards : Whole Blood, Lymph Node, Bone Marrow, Brain, Eye, Pituitary, Kidney

Publications for Latent Syphilis

Articles related to Latent Syphilis:

(show top 50) (show all 571)
# Title Authors PMID Year
1
Anal and oral detection of Treponema pallidum in men who have sex with men with early syphilis infection. 62
35618414 2022
2
Developing a symptoms-based risk score for infectious syphilis among men who have sex with men. 62
36400527 2022
3
Incidence and risk factors for syphilis infection among men who have sex with men: A cohort study from an urban sexual health clinic in Jakarta, Indonesia. 62
36067281 2022
4
Making a Comeback: Syphilitic Hepatitis in a Patient with Late Latent Syphilis-Case Report and Review of the Literature. 62
36297208 2022
5
Detection of Treponema pallidum DNA During Early Syphilis Stages in Peripheral Blood, Oropharynx, Ano-Rectum and Urine as a Proxy for Transmissibility. 62
35079776 2022
6
Tp0684, Tp0750, and Tp0792 Recombinant Proteins as Antigens for the Serodiagnosis of Syphilis. 62
35974924 2022
7
Clinical and laboratory features in patients with positive syphilis serology presenting with acute ischemic stroke or transient ischemic attack: a prospective cohort study. 62
36042411 2022
8
Clinical presentation and serological diagnosis of syphilis reinfection in men living with HIV: a retrospective cohort study. 62
34475233 2022
9
Lumbar puncture for neurosyphilis investigation in asymptomatic patients with HIV-syphilis coinfection: a cross-sectional study among infectious disease specialists. 62
36043668 2022
10
Associations between Antenatal Syphilis Test Results and Adverse Pregnancy Outcomes in Western Kenya. 62
35895406 2022
11
British Columbia's Experience after Implementation of the Treponema pallidum Reverse Algorithm and PCR Detection, 2015 to 2020. 62
35658597 2022
12
Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis. 62
33782148 2022
13
The treatment outcome and predictors of serological response in syphilis in a sexually transmitted infections center, China. 62
35384775 2022
14
Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients. 62
35315702 2022
15
Asymptomatic latent syphilis in geriatric patients in association with stoke: Analysis using routine syphilis tests. 62
34949547 2022
16
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. 62
35416969 2022
17
Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses. 62
33608479 2022
18
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis. 62
34978502 2022
19
Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South-East Queensland. 62
34463955 2022
20
Spatiotemporal distribution analysis of syphilis in Brazil: Cases of congenital and syphilis in pregnant women from 2001-2017. 62
36201505 2022
21
Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages. 62
35859909 2022
22
Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy. 62
35819944 2022
23
Disease Surveillance Among U.S.-Bound Immigrants and Refugees - Electronic Disease Notification System, United States, 2014-2019. 62
35051136 2022
24
Cerebrospinal Fluid Changes and Clinical Features of Neurosyphilis Compared with Latent Syphilis Infection in the Central Nervous System: A Cross-Sectional Study. 62
36110129 2022
25
Advances in laboratory diagnostic methods for cerebrospinal fluid testing for neurosyphilis. 62
36452956 2022
26
A New Specimen for Syphilis Diagnosis: Evidence by High Loads of Treponema pallidum DNA in Saliva. 62
33099614 2021
27
Treponema pallidum detection in lesion and non-lesion sites in men who have sex with men with early syphilis: a prospective, cross-sectional study. 62
33894904 2021
28
Comparisons of Serologic Responses of Early Syphilis to Treatment with a Single-Dose Benzathine Penicillin G Between HIV-Positive and HIV-Negative Patients. 62
33948910 2021
29
A Case of Focal Segmental Glomerulosclerosis With Immune Complexes: Is HIV, Hepatitis B, or Crack the Culprit? 62
34557371 2021
30
Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum. 62
33980645 2021
31
Nodular syphilitic scleritis: a rare and forgotten entity. 62
33599170 2021
32
Efficacy of minocycline in the treatment of early syphilis. 62
33496202 2021
33
An unusual case of oral condyloma lata. 62
33607303 2021
34
The resurgence of syphilis among pregnant women in southern Chile. 62
34479313 2021
35
High-risk sexual behavior and HIV/STDs cascade of care in migrants: results from an Italian dedicated outpatient clinic. 62
33690214 2021
36
A Failure of Rapid Drug Desensitization. 62
33748854 2021
37
MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in Peripheral Blood Mononuclear Cells May Serve as Novel Biomarkers for Syphilis Diagnosis. 62
33524569 2021
38
Syphilis infection and epidemiological characteristics in Haidian District, Beijing, China, 2013-2018. 62
33360028 2021
39
A congenital syphilitic child to an adequately treated syphilitic mother. 62
34765943 2021
40
Diagnosis, treatment, and notification of syphilis during pregnancy in the state of Goiás, Brazil, between 2007 and 2017. 62
34730749 2021
41
Females treated for syphilis in Bialystok, Poland 2016-2020. 62
35543433 2021
42
Characterization of HIV-Associated Neurocognitive Impairment in Middle-Aged and Older Persons With HIV in Lima, Peru. 62
34220665 2021
43
Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China. 62
34900903 2021
44
Prevalence of latent tuberculosis infection, hepatitis B, hepatitis C, and syphilis among newly arrived unaccompanied minors living in reception centers in Rome. 62
32947054 2020
45
Epidemiology of sexually transmitted infections among female sex workers in Switzerland: a local, exploratory, cross-sectional study. 62
33378545 2020
46
Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis. 62
33298143 2020
47
Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania. 62
33276749 2020
48
Annular and arciform lesions of the palms as unique manifestations of secondary syphilis. 62
32981425 2020
49
Don't forget syphilis in membranous nephropathy before immunosuppressants: Latent syphilis in a patient with proteinuria. 62
32144011 2020
50
Deciphering the serological response to syphilis treatment in men living with HIV. 62
32773482 2020

Variations for Latent Syphilis

Expression for Latent Syphilis

Search GEO for disease gene expression data for Latent Syphilis.

Pathways for Latent Syphilis

Pathways related to Latent Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 IFNG CD4
2 10.62 IFNG CD4
3 10.39 IFNG CD4
4 9.8 IFNG CD4

GO Terms for Latent Syphilis

Biological processes related to Latent Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 macrophage differentiation GO:0030225 8.92 IFNG CD4

Sources for Latent Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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