MCID: LTR005
MIFTS: 22

Lateral Displacement of Eye

Categories: Eye diseases

Aliases & Classifications for Lateral Displacement of Eye

MalaCards integrated aliases for Lateral Displacement of Eye:

Name: Lateral Displacement of Eye 12 15
Lateral Displacement of Globe 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12360
ICD9CM 34 376.36
SNOMED-CT 67 48747004
ICD10 32 H05.21
UMLS 71 C0155272

Summaries for Lateral Displacement of Eye

MalaCards based summary : Lateral Displacement of Eye, also known as lateral displacement of globe, is related to albinism, ocular, with sensorineural deafness and tonsil cancer. An important gene associated with Lateral Displacement of Eye is TRIM8 (Tripartite Motif Containing 8), and among its related pathways/superpathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Neural Crest Differentiation. Affiliated tissues include eye, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Lateral Displacement of Eye

Diseases related to Lateral Displacement of Eye via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 albinism, ocular, with sensorineural deafness 9.9 PAX3 MITF
2 tonsil cancer 9.9 SOX10 SNAI2
3 waardenburg syndrome, type 2b 9.9 SOX10 MITF
4 malignant choroid melanoma 9.9 SOX10 MITF
5 gallbladder melanoma 9.8 SOX10 MITF
6 albinism, ocular, with late-onset sensorineural deafness 9.8 SOX10 MITF
7 malignant spindle cell melanoma 9.8 SOX10 MITF
8 clear cell sarcoma 9.8 SOX10 MITF
9 actinic keratosis 9.8 SOX10 MITF
10 neurilemmoma 9.7 SOX10 MITF
11 neurofibroma 9.7 SOX10 MITF
12 pendred syndrome 9.6 SLC26A4 PAX3 MITF
13 intestinal pseudo-obstruction 9.6 SOX10 EDNRB
14 diaphragmatic hernia, congenital 9.4 PAX3 EDNRB
15 cochlear disease 9.4 SOX10 SLC26A4 EDNRB
16 megacolon 9.4 SOX10 PAX3 EDNRB
17 nonsyndromic deafness 9.3 TRIM8 SLC26A4 PAX3 MITF
18 microphthalmia 9.3 SOX10 PAX3 MITF
19 waardenburg syndrome type 4 9.3 SOX10 MITF EDNRB
20 central hypoventilation syndrome, congenital 9.2 SOX10 EDNRB
21 melanoma, cutaneous malignant 1 9.2 SOX10 MITF EDNRB
22 sensorineural hearing loss 9.2 SOX10 SLC26A4 PAX3 MITF
23 waardenburg syndrome, type 4c 8.9 SOX10 PAX3 MITF EDNRB
24 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 8.9 SOX10 PAX3 MITF EDNRB
25 waardenburg syndrome, type 2a 8.9 SOX10 PAX3 MITF EDNRB
26 tietz albinism-deafness syndrome 8.9 SOX10 PAX3 MITF EDNRB
27 waardenburg syndrome, type 4a 8.9 SOX10 PAX3 MITF EDNRB
28 rare genetic deafness 8.6 SOX10 SLC26A4 PAX3 MITF EDNRB
29 waardenburg syndrome, type 2d 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
30 waardenburg syndrome, type 2c 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
31 waardenburg syndrome, type 4b 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
32 waardenburg syndrome, type 2e 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
33 waardenburg syndrome, type 3 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
34 waardenburg syndrome, type 1 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
35 piebald trait 8.6 SOX10 SNAI2 PAX3 MITF EDNRB
36 waardenburg's syndrome 8.5 SOX10 SNAI2 PAX3 MITF EDNRB
37 hirschsprung disease 1 8.5 SOX10 SNAI2 PAX3 MITF EDNRB

Graphical network of the top 20 diseases related to Lateral Displacement of Eye:



Diseases related to Lateral Displacement of Eye

Symptoms & Phenotypes for Lateral Displacement of Eye

MGI Mouse Phenotypes related to Lateral Displacement of Eye:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 EDNRB MITF PAX3 SLC26A4 SNAI2 SOX10
2 homeostasis/metabolism MP:0005376 9.98 EDNRB MITF PAX3 SLC26A4 SNAI2 SOX10
3 endocrine/exocrine gland MP:0005379 9.95 EDNRB MITF PAX3 SLC26A4 SNAI2 SOX10
4 digestive/alimentary MP:0005381 9.91 EDNRB PAX3 SLC26A4 SNAI2 SOX10
5 embryo MP:0005380 9.89 EDNRB MITF PAX3 SNAI2 SOX10
6 immune system MP:0005387 9.88 EDNRB MITF PAX3 SLC26A4 SNAI2 TRIM8
7 craniofacial MP:0005382 9.83 EDNRB MITF PAX3 SNAI2
8 integument MP:0010771 9.77 EDNRB MITF PAX3 SNAI2 SOX10
9 hearing/vestibular/ear MP:0005377 9.76 EDNRB MITF PAX3 SLC26A4
10 nervous system MP:0003631 9.73 EDNRB MITF PAX3 SLC26A4 SNAI2 SOX10
11 pigmentation MP:0001186 9.63 EDNRB MITF PAX3 SLC26A4 SNAI2 SOX10
12 limbs/digits/tail MP:0005371 9.62 EDNRB MITF PAX3 SOX10
13 renal/urinary system MP:0005367 9.26 EDNRB MITF PAX3 SLC26A4
14 skeleton MP:0005390 9.1 EDNRB MITF PAX3 SLC26A4 SNAI2 TRIM8

Drugs & Therapeutics for Lateral Displacement of Eye

Search Clinical Trials , NIH Clinical Center for Lateral Displacement of Eye

Genetic Tests for Lateral Displacement of Eye

Anatomical Context for Lateral Displacement of Eye

MalaCards organs/tissues related to Lateral Displacement of Eye:

40
Eye

Publications for Lateral Displacement of Eye

Variations for Lateral Displacement of Eye

Expression for Lateral Displacement of Eye

Search GEO for disease gene expression data for Lateral Displacement of Eye.

Pathways for Lateral Displacement of Eye

Pathways related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 SNAI2 MITF
2 10.93 SOX10 SNAI2 PAX3 MITF
3 10.9 PAX3 MITF
4 10.74 SOX10 PAX3 MITF

GO Terms for Lateral Displacement of Eye

Cellular components related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 SOX10 SNAI2 PAX3 MITF

Biological processes related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.62 SOX10 SNAI2 MITF EDNRB
2 neural crest cell migration GO:0001755 9.43 SOX10 EDNRB
3 sensory perception of sound GO:0007605 9.43 SNAI2 SLC26A4 PAX3
4 peripheral nervous system development GO:0007422 9.4 SOX10 EDNRB
5 regulation of pH GO:0006885 9.37 SLC26A4 EDNRB
6 enteric nervous system development GO:0048484 9.16 SOX10 EDNRB
7 pigmentation GO:0043473 9.13 SNAI2 MITF EDNRB
8 melanocyte differentiation GO:0030318 8.8 SOX10 MITF EDNRB

Molecular functions related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.43 SOX10 SNAI2 MITF
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.26 SOX10 SNAI2 PAX3 MITF
3 E-box binding GO:0070888 9.16 SNAI2 MITF
4 DNA-binding transcription factor activity GO:0003700 8.92 SOX10 SNAI2 PAX3 MITF

Sources for Lateral Displacement of Eye

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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