MCID: LTR005
MIFTS: 14

Lateral Displacement of Eye

Categories: Bone diseases

Aliases & Classifications for Lateral Displacement of Eye

MalaCards integrated aliases for Lateral Displacement of Eye:

Name: Lateral Displacement of Eye 12 15
Lateral Displacement of Globe 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12360
ICD9CM 34 376.36
SNOMED-CT 67 48747004
ICD10 32 H05.21
UMLS 71 C0155272

Summaries for Lateral Displacement of Eye

MalaCards based summary : Lateral Displacement of Eye, also known as lateral displacement of globe, is related to transient refractive change and cycloplegia. An important gene associated with Lateral Displacement of Eye is LCN1 (Lipocalin 1). Affiliated tissues include eye and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Lateral Displacement of Eye

Diseases related to Lateral Displacement of Eye via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 transient refractive change 9.4 IRX6 IRX3
2 cycloplegia 9.2 IRX6 IRX3

Symptoms & Phenotypes for Lateral Displacement of Eye

GenomeRNAi Phenotypes related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.5 SIX6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.5 SIX6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 EMX2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.5 SIX6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.5 SIX6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.5 SIX6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.5 EMX2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-154 9.5 EMX2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.5 SIX6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.5 EMX2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.5 EMX2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.5 SIX6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 EMX2 SIX6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.5 EMX2

MGI Mouse Phenotypes related to Lateral Displacement of Eye:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 EFNA4 EMX2 IRX3 IRX6 SIX6

Drugs & Therapeutics for Lateral Displacement of Eye

Search Clinical Trials , NIH Clinical Center for Lateral Displacement of Eye

Genetic Tests for Lateral Displacement of Eye

Anatomical Context for Lateral Displacement of Eye

MalaCards organs/tissues related to Lateral Displacement of Eye:

40
Eye, Bone

Publications for Lateral Displacement of Eye

Variations for Lateral Displacement of Eye

Expression for Lateral Displacement of Eye

Search GEO for disease gene expression data for Lateral Displacement of Eye.

Pathways for Lateral Displacement of Eye

GO Terms for Lateral Displacement of Eye

Cellular components related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 SIX6 IRX6 IRX3 EMX2

Biological processes related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.56 SIX6 IRX6 IRX3 EMX2
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.5 IRX6 IRX3 EMX2
3 regulation of transcription by RNA polymerase II GO:0006357 9.26 SIX6 IRX6 IRX3 EMX2
4 cell development GO:0048468 9.16 IRX6 IRX3
5 neuron differentiation GO:0030182 8.8 IRX6 IRX3 EMX2

Molecular functions related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 SIX6 IRX6 IRX3 EMX2
2 sequence-specific DNA binding GO:0043565 9.33 IRX6 IRX3 EMX2
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.26 SIX6 IRX6 IRX3 EMX2
4 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 8.8 IRX6 IRX3 EMX2

Sources for Lateral Displacement of Eye

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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