MCID: LTR005
MIFTS: 15

Lateral Displacement of Eye

Categories: Bone diseases, Eye diseases
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Aliases & Classifications for Lateral Displacement of Eye

MalaCards integrated aliases for Lateral Displacement of Eye:

Name: Lateral Displacement of Eye 11 14
Lateral Displacement of Globe 11

Classifications:



External Ids:

Disease Ontology 11 DOID:12360
ICD9CM 34 376.36
SNOMED-CT 68 48747004
UMLS 71 C0155272

Summaries for Lateral Displacement of Eye

MalaCards based summary: Lateral Displacement of Eye, also known as lateral displacement of globe, is related to colobomatous microphthalmia and schizencephaly. An important gene associated with Lateral Displacement of Eye is LCN1 (Lipocalin 1). Affiliated tissues include eye and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and vision/eye

Related Diseases for Lateral Displacement of Eye

Diseases related to Lateral Displacement of Eye via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colobomatous microphthalmia 9.8 SIX6 SIX3
2 schizencephaly 9.8 SIX3 EMX2
3 anterior segment dysgenesis 9.8 SIX6 SIX3
4 coloboma of macula 9.7 SIX6 SIX3
5 holoprosencephaly 9.6 SIX3 EMX2
6 septooptic dysplasia 9.5 SIX6 SIX3 EMX2

Graphical network of the top 20 diseases related to Lateral Displacement of Eye:



Diseases related to Lateral Displacement of Eye

Symptoms & Phenotypes for Lateral Displacement of Eye

GenomeRNAi Phenotypes related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.5 SIX6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.5 SIX6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 EMX2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.5 SIX6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.5 SIX6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.5 SIX6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.5 EMX2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-154 9.5 EMX2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.5 SIX6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.5 EMX2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.5 EMX2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.5 SIX6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 EMX2 SIX6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.5 EMX2

MGI Mouse Phenotypes related to Lateral Displacement of Eye:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.26 EMX2 IRX6 SIX3 SIX6
2 taste/olfaction MP:0005394 8.62 EMX2 SIX3

Drugs & Therapeutics for Lateral Displacement of Eye

Search Clinical Trials, NIH Clinical Center for Lateral Displacement of Eye

Genetic Tests for Lateral Displacement of Eye

Anatomical Context for Lateral Displacement of Eye

Organs/tissues related to Lateral Displacement of Eye:

MalaCards : Eye, Bone

Publications for Lateral Displacement of Eye

Variations for Lateral Displacement of Eye

Expression for Lateral Displacement of Eye

Search GEO for disease gene expression data for Lateral Displacement of Eye.

Pathways for Lateral Displacement of Eye

GO Terms for Lateral Displacement of Eye

Cellular components related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.23 SIX6 SIX3 IRX6 EMX2

Biological processes related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.86 SIX6 SIX3 IRX6 EMX2
2 regulation of DNA-templated transcription GO:0006355 9.46 SIX6 SIX3 IRX6 EMX2
3 eye development GO:0001654 9.26 SIX6 SIX3
4 cell proliferation in forebrain GO:0021846 8.92 SIX3 EMX2

Molecular functions related to Lateral Displacement of Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific double-stranded DNA binding GO:1990837 9.63 SIX6 SIX3 EMX2
2 DNA binding GO:0003677 9.56 SIX6 SIX3 IRX6 EMX2
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.56 SIX6 SIX3 IRX6 EMX2
4 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 9.23 SIX6 SIX3 IRX6 EMX2

Sources for Lateral Displacement of Eye

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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