MCID: LTR003
MIFTS: 35

Lateral Medullary Syndrome

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Lateral Medullary Syndrome

MalaCards integrated aliases for Lateral Medullary Syndrome:

Name: Lateral Medullary Syndrome 12 20 53 44 15 17 70
Posterior Inferior Cerebellar Artery Syndrome 12 20
Vertebral Artery Syndrome 20 70
Wallenberg's Syndrome 20 53
Wallenberg Syndrome 12 20
Pica Syndrome 20

Classifications:



External Ids:

Disease Ontology 12 DOID:3522
MeSH 44 D014854
NCIt 50 C84807
SNOMED-CT 67 78569004
ICD10 32 G46.3
UMLS 70 C0043019 C2931914

Summaries for Lateral Medullary Syndrome

NINDS : 53 Wallenberg’s syndrome is a neurological condition caused by a stroke in the vertebral or posterior inferior cerebellar artery of the brain stem. Symptoms include difficulties with swallowing, hoarseness, dizziness, nausea and vomiting, rapid involuntary movements of the eyes (nystagmus), and problems with balance and gait coordination. Some individuals will experience a lack of pain and temperature sensation on only one side of the face, or a pattern of symptoms on opposite sides of the body – such as paralysis or numbness in the right side of the face, with weak or numb limbs on the left side. Uncontrollable hiccups may also occur, and some individuals will lose their sense of taste on one side of the tongue, while preserving taste sensations on the other side. Some people with Wallenberg’s syndrome report that the world seems to be tilted in an unsettling way, which makes it difficult to keep their balance when they walk.

MalaCards based summary : Lateral Medullary Syndrome, also known as posterior inferior cerebellar artery syndrome, is related to syphilis and temporal arteritis, and has symptoms including vertigo, ipsilateral cerebellar signs and contralateral sensory deficits of limbs. An important gene associated with Lateral Medullary Syndrome is CPM (Carboxypeptidase M). Affiliated tissues include lateral part of the medulla oblongata, medulla oblongata and brain.

Disease Ontology : 12 A brain stem infarction that is characterized by hoarseness, dizziness, nausea, located in the lateral part of the medulla oblongata that develops from a blockage in the posterior inferior cerebellar artery or one of its branches or of the vertebral artery, has symptom vertigo, has symptom ipsilateral cerebellar signs, has symptom contralateral sensory deficits of limbs and torso, has symptom ipsilateral sensory deficits of face, has symptom laryngeal, pharyngeal, and palatal hemiparalysis, has symptom ipsilateral Horner's syndrome.

GARD : 20 Wallenberg syndrome is a condition that affects the nervous system. Signs and symptoms may include swallowing difficulties, dizziness, hoarseness, nausea and vomiting, nystagmus, and problems with balance. Some people have uncontrollable hiccups, loss of pain and temperature sensation on one side of the face, and/or weakness or numbness on one side of the body. Wallenberg syndrome is often caused by a stroke in the brain stem. Treatment addresses each symptom and may include a feeding tube for swallowing problems, speech and/or swallowing therapy, and medication for pain. While some people's symptoms may improve within weeks or months, others may have long-term neurological problems.

Wikipedia : 73 Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the... more...

Related Diseases for Lateral Medullary Syndrome

Diseases related to Lateral Medullary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 syphilis 29.5 PRTN3 APOH
2 temporal arteritis 29.5 PRTN3 APOH
3 sjogren syndrome 29.3 PRTN3 APOH
4 vertebral artery insufficiency 11.4
5 dysphagia 10.5
6 pathologic nystagmus 10.4
7 ataxia and polyneuropathy, adult-onset 10.4
8 horner's syndrome 10.3
9 osteochondrosis 10.2
10 vertebral artery occlusion 10.2
11 cerebrovascular disease 10.1
12 facial paralysis 10.1
13 pica disease 10.1
14 arteriosclerosis 10.1
15 vertebrobasilar insufficiency 10.1
16 myoclonus 10.1
17 chronic hiccups 10.0
18 chickenpox 10.0
19 vasculitis 10.0
20 inappropriate adh syndrome 10.0
21 hemiplegia 10.0
22 osteomyelitis 10.0
23 ptosis 10.0
24 aspiration pneumonia 10.0
25 migraine with or without aura 1 10.0
26 fibromuscular dysplasia 10.0
27 paresthesia 10.0
28 neurotrophic keratopathy 10.0
29 keratopathy 10.0
30 demyelinating disease 10.0
31 glossopharyngeal nerve disease 10.0 PRTN3 CANX
32 cranial nerve palsy 10.0 SLC52A1 PRTN3
33 glossopharyngeal neuralgia 10.0 SLC52A1 CANX
34 schwannoma of twelfth cranial nerve 10.0 SLC52A1 CANX
35 hypoglossal nerve disease 10.0 SLC52A1 CANX
36 endobronchial leiomyoma 10.0 PRTN3 CR1
37 afibrinogenemia, congenital 9.9 FGB CR1
38 chiari malformation 9.9
39 herpes simplex encephalitis 9.9
40 migraine with brainstem aura 9.9
41 cavernous malformation 9.9
42 head injury 9.9
43 headache 9.9
44 specific language disorder 9.9
45 central pain syndrome 9.9
46 bap1 tumor predisposition syndrome 9.9
47 hypotropia 9.9
48 encephalitis 9.9
49 hypopituitarism 9.9
50 herpes simplex 9.9

Graphical network of the top 20 diseases related to Lateral Medullary Syndrome:



Diseases related to Lateral Medullary Syndrome

Symptoms & Phenotypes for Lateral Medullary Syndrome

Symptoms:

12
  • vertigo
  • ipsilateral cerebellar signs
  • contralateral sensory deficits of limbs
  • ipsilateral sensory deficits of face
  • laryngeal
  • ipsilateral horner's syndrome

Drugs & Therapeutics for Lateral Medullary Syndrome

Search Clinical Trials , NIH Clinical Center for Lateral Medullary Syndrome

Cochrane evidence based reviews: lateral medullary syndrome

Genetic Tests for Lateral Medullary Syndrome

Anatomical Context for Lateral Medullary Syndrome

The Foundational Model of Anatomy Ontology organs/tissues related to Lateral Medullary Syndrome:

19
Lateral Part Of The Medulla Oblongata

MalaCards organs/tissues related to Lateral Medullary Syndrome:

40
Medulla Oblongata, Brain, Tongue, Eye, Cortex, Skin, Spinal Cord

Publications for Lateral Medullary Syndrome

Articles related to Lateral Medullary Syndrome:

(show top 50) (show all 464)
# Title Authors PMID Year
1
Lateral medullary syndrome due to brain stem tuberculoma. 61 20
21751596 2011
2
Wallenberg syndrome caused by multiple sclerosis mimicking stroke. 20 61
19800798 2009
3
Lateral medullary syndrome caused by penetrating head injury. 61 20
16914313 2006
4
Lateral medullary syndrome following varicella infection. 61 20
8352215 1993
5
The association between contraversive lateropulsion and outcomes post stroke: A systematic review. 61
33648434 2021
6
Incoordination during the pharyngeal phase in severe dysphagia due to lateral medullary syndrome. 61
33768924 2021
7
Dorsolateral medullary infarction registry: a study protocol for a prospective, multicentric registry. 61
33435910 2021
8
Ocular lateral deviation with brief removal of visual fixation differentiates central from peripheral vestibular syndrome. 61
32719976 2020
9
Lateral Medullary Syndrome Following Injury of Lateral Vestibulospinal Tract: Diffusion Tensor Imaging Study. 61
33066903 2020
10
The Trouble with Swallowing: Dysphagia as the Presenting Symptom in Lateral Medullary Syndrome. 61
32682639 2020
11
Ultrasonography-guided botulinum toxin injection to the cricopharyngeus muscle: a case report and technical notes. 61
32190858 2020
12
Injury of the lateral vestibulospinal tract in a patient with the lateral medullary syndrome: Case report. 61
32925758 2020
13
Gasperini Syndrome: A Case Report and Systematic Review and Proposing a New Definition. 61
33362523 2020
14
Dysphagia in Lateral Medullary Syndrome: A Narrative Review. 61
32654058 2020
15
A Rare Variant of the Lateral Medullary Syndrome with Craniovertebral Junction and Vascular Anomalies. 61
32859848 2020
16
Hyoid-complex elevation and stimulation technique restores swallowing function in patients with lateral medullary syndrome: Two case reports. 61
32258085 2020
17
Comorbid SUNCT Syndrome and Opalski Syndrome Caused by Dorsolateral Medullary Infarction. 61
32117015 2020
18
A Case of Wallenberg's Syndrome Presenting with Spontaneous Thrombosis of a Vertebral Artery Aneurysm. 61
31727598 2020
19
Clinical Importance of the Posterior Inferior Cerebellar Artery: A Review of the Literature. 61
33173421 2020
20
Left Far Lateral Craniotomy for Clipping of a Posterior Inferior Cerebellar Artery Aneurysm. 61
31750053 2019
21
An atypical manifestation of lateral medullary syndrome. 61
31908829 2019
22
Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome. 61
31609320 2019
23
Fatal Progression of Gorham-Stout Disease with Skull Base Osteomyelitis and Lateral Medullary Syndrome. 61
30799352 2019
24
Spontaneous Vertebral Artery Dissection and Thrombosis Presenting as Lateral Medullary Syndrome. 61
31595124 2019
25
A case of varicella zoster encephalitis with glossopharyngeal and vagus nerve injury as primary manifestation combined with medulla lesion. 61
30880528 2019
26
Lateral Medullary Syndrome Due to Left Vertebral Artery Occlusion in a Boy Postflexion Neck Injury. 61
31763345 2019
27
Left Atrial Myxoma Presenting as Lateral Medullary (Wallenberg's) Syndrome. 61
31827936 2019
28
Lateral medullary infarction with cardiovascular autonomic dysfunction: an unusual presentation with review of the literature. 61
29368226 2018
29
Fine margin between crossed sensory and contralateral sensory loss: A case report. 61
29937417 2018
30
False-negative diagnostic imaging of Wallenberg's syndrome by diffuse-weighted imaging: a case report and literature review. 61
29627941 2018
31
Utility of thermographic measurements of laterality of body surface temperature to prevent misdiagnosis of acute Wallenberg's syndrome. 61
29993195 2018
32
Case report: Wallenberg's syndrome, a possible cause of symptomatic epicrania fugax. 61
28786694 2018
33
Vertebral artery dissection stroke in evolution presented with postural headache as initial manifestation. 61
30069291 2018
34
Vertebral Artery Occlusion Causing Facial Colliculus and Opalski Stroke Syndromes Simultaneously. 61
29722745 2018
35
Brain Stem Ischemic Stroke Associated with Anaphylaxis. 61
29744255 2018
36
[Trigeminal Herpes Zoster Presenting with High-intensity Signals for the Spinal Trigeminal Nucleus and Tract on Diffusion-weighted Image: A Case Report of Stroke Mimic]. 61
29433118 2018
37
Reversible drug-induced antiphospholipid syndrome. 61
28592198 2018
38
Lateral medullary syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study. 61
29217256 2018
39
Clinical course and outcome in patients with severe dysphagia after lateral medullary syndrome. 61
29511384 2018
40
Double conduction through the atrioventricular node following acute medullary infarction: a case report. 61
29404361 2018
41
Sarcoidosis presenting as Wallenberg syndrome and panuveitis. 61
29977748 2018
42
Neuroimaging "HINTS" of the Lateral Medullary Syndrome. 61
28471903 2017
43
Efficacy of botulinum toxin type-A and swallowing treatment for oropharyngeal dysphagia recovery in a patient with lateral medullary syndrome. 61
28264544 2017
44
After Effects of Cerebellar Continuous Theta Burst Stimulation on Reflexive Saccades and Smooth Pursuit in Humans. 61
28303385 2017
45
Crossed cheiro-oral syndrome: A warning sign for medullary involvement and neurological deterioration. 61
28089423 2017
46
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. 61
28488638 2017
47
Progressive Bilateral Vertebral Artery Dissection in a Case of Osteogenesis Imperfecta. 61
28089253 2017
48
Treatment of Wallenberg's Syndrome related dysphagia with pyridostigmine. 61
27424039 2017
49
Posterior inferior cerebellar artery susceptibility sign in lateral medullary syndrome. 61
28290427 2017
50
Lateral medullary syndrome after a scorpion sting. 61
29026772 2017

Variations for Lateral Medullary Syndrome

Expression for Lateral Medullary Syndrome

Search GEO for disease gene expression data for Lateral Medullary Syndrome.

Pathways for Lateral Medullary Syndrome

GO Terms for Lateral Medullary Syndrome

Cellular components related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.43 PRTN3 FGB APOH
2 cell surface GO:0009986 9.26 FGB CR1 CPM APOH
3 plasma membrane raft GO:0044853 9.16 PRTN3 CR1
4 extracellular exosome GO:0070062 9.1 PRTN3 FGB CR1 CPM CANX APOH

Biological processes related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 8.96 SLC52A1 CR1
2 plasminogen activation GO:0031639 8.62 FGB APOH

Molecular functions related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 SLC52A1 CR1

Sources for Lateral Medullary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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