MCID: LTR003
MIFTS: 43

Lateral Medullary Syndrome

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lateral Medullary Syndrome

MalaCards integrated aliases for Lateral Medullary Syndrome:

Name: Lateral Medullary Syndrome 12 53 54 44 15 73
Posterior Inferior Cerebellar Artery Syndrome 12 53
Vertebral Artery Syndrome 53 73
Wallenberg's Syndrome 53 54
Wallenberg Syndrome 12 53
Pica Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3522
ICD10 33 G46.3
MeSH 44 D014854
NCIt 50 C84807
SNOMED-CT 68 78569004

Summaries for Lateral Medullary Syndrome

NINDS : 54 Wallenberg’s syndrome is a neurological condition caused by a stroke in the vertebral or posterior inferior cerebellar artery of the brain stem. Symptoms include difficulties with swallowing, hoarseness, dizziness, nausea and vomiting, rapid involuntary movements of the eyes (nystagmus), and problems with balance and gait coordination. Some individuals will experience a lack of pain and temperature sensation on only one side of the face, or a pattern of symptoms on opposite sides of the body – such as paralysis or numbness in the right side of the face, with weak or numb limbs on the left side. Uncontrollable hiccups may also occur, and some individuals will lose their sense of taste on one side of the tongue, while preserving taste sensations on the other side. Some people with Wallenberg’s syndrome report that the world seems to be tilted in an unsettling way, which makes it difficult to keep their balance when they walk.

MalaCards based summary : Lateral Medullary Syndrome, also known as posterior inferior cerebellar artery syndrome, is related to vertebral artery insufficiency and parapharyngeal meningioma, and has symptoms including vertigo, ipsilateral cerebellar signs and contralateral sensory deficits of limbs. An important gene associated with Lateral Medullary Syndrome is FGB (Fibrinogen Beta Chain), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include brain, medulla oblongata and eye.

Disease Ontology : 12 A brain stem infarction that is characterized by hoarseness, dizziness, nausea, located in the lateral part of the medulla oblongata that develops from a blockage in the posterior inferior cerebellar artery or one of its branches or of the vertebral artery, has symptom vertigo, has symptom ipsilateral cerebellar signs, has symptom contralateral sensory deficits of limbs and torso, has symptom ipsilateral sensory deficits of face, has symptom laryngeal, pharyngeal, and palatal hemiparalysis, has symptom ipsilateral Horner's syndrome.

NIH Rare Diseases : 53 Wallenberg syndromeis a condition that affects the nervous system. Signs and symptoms may include swallowing difficulties, dizziness, hoarseness, nausea and vomiting, nystagmus, and problems with balance. Some people have uncontrollable hiccups, loss of pain and temperature sensation on one side of the face, and/or weakness or numbness on one side of the body. Wallenberg syndrome is often caused by a stroke in the brain stem. Treatment addresses each symptom and may include a feeding tube for swallowing problems, speech and/or swallowing therapy, and medication for pain. While some people's symptoms may improve within weeks or months, others may have long-term neurological problems.

Wikipedia : 76 Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the... more...

Related Diseases for Lateral Medullary Syndrome

Diseases related to Lateral Medullary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 vertebral artery insufficiency 11.6
2 parapharyngeal meningioma 10.3 CR1 CR2
3 histiocytic sarcoma 10.3 CR1 CR2
4 interdigitating dendritic cell sarcoma 10.3 CR1 CR2
5 langerhans cell sarcoma 10.3 CR1 CR2
6 immunodeficiency, common variable, 2 10.3 CD19 CR2
7 lobomycosis 10.3 CD19 CR2
8 t-cell/histiocyte rich large b cell lymphoma 10.3 CR1 CR2
9 central nervous system leukemia 10.2 CD19 CR1
10 histiocytic and dendritic cell cancer 10.2 CR1 CR2
11 bladder lymphoma 10.2 CD19 CR2
12 reticulum cell sarcoma 10.2 CR1 CR2
13 colon lymphoma 10.2 CD19 CD22
14 fungal esophagitis 10.2 ATP12A ATP4A
15 diclofenac allergy 10.2 ATP12A ATP4A
16 gastroduodenal crohn's disease 10.2 ATP12A ATP4A
17 neonatal candidiasis 10.2 ATP12A ATP4A
18 photoallergic dermatitis 10.2 ATP12A ATP4A
19 squamous papillomatosis 10.2 ATP12A ATP4A
20 toxic megacolon 10.2 ATP12A ATP4A
21 aspiration pneumonitis 10.2 ATP12A ATP4A
22 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
23 gastric antral vascular ectasia 10.2 ATP12A ATP4A
24 esophageal candidiasis 10.2 ATP12A ATP4A
25 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
26 acute laryngitis 10.2 ATP12A ATP4A
27 laryngitis 10.2 ATP12A ATP4A
28 duodenitis 10.2 ATP12A ATP4A
29 rumination disorder 10.2 ATP12A ATP4A
30 active peptic ulcer disease 10.2 ATP12A ATP4A
31 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
32 hyperhidrosis, gustatory 10.2 CANX KANTR
33 bladder calculus 10.2 ATP12A ATP4A
34 ischemic neuropathy 10.2 ATP12A ATP4A
35 bile reflux 10.2 ATP12A ATP4A
36 capillary disease 10.2 ATP12A ATP4A
37 peptic esophagitis 10.2 ATP12A ATP4A
38 dyskinesia of esophagus 10.2 ATP12A ATP4A
39 hernia, hiatus 10.2 ATP12A ATP4A
40 lung lymphoma 10.2 CD19 CD22 CR2
41 leukocyte disease 10.2 CD19 CD22 CR2
42 postsurgical hypothyroidism 10.2 ATP12A ATP4A
43 brain stem infarction 10.2 FGB MRPS22 PLG
44 lymphocytic colitis 10.2 ATP12A ATP4A
45 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
46 clostridium difficile colitis 10.2 ATP12A ATP4A
47 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
48 sphenoid sinusitis 10.2 KANTR MRPS22
49 microscopic colitis 10.1 ATP12A ATP4A
50 chronic laryngitis 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Lateral Medullary Syndrome:



Diseases related to Lateral Medullary Syndrome

Symptoms & Phenotypes for Lateral Medullary Syndrome

Symptoms:

12
  • vertigo
  • ipsilateral cerebellar signs
  • contralateral sensory deficits of limbs
  • ipsilateral sensory deficits of face
  • laryngeal
  • ipsilateral horner's syndrome

Drugs & Therapeutics for Lateral Medullary Syndrome

Search Clinical Trials , NIH Clinical Center for Lateral Medullary Syndrome

Cochrane evidence based reviews: lateral medullary syndrome

Genetic Tests for Lateral Medullary Syndrome

Anatomical Context for Lateral Medullary Syndrome

MalaCards organs/tissues related to Lateral Medullary Syndrome:

41
Brain, Medulla Oblongata, Eye, Tongue, Skin, B Cells, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Lateral Medullary Syndrome:

19
The Lateral Part Of The Medulla Oblongata

Publications for Lateral Medullary Syndrome

Articles related to Lateral Medullary Syndrome:

(show top 50) (show all 90)
# Title Authors Year
1
Clinical course and outcome in patients with severe dysphagia after lateral medullary syndrome. ( 29511384 )
2018
2
Lateral medullary syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study. ( 29217256 )
2018
3
Efficacy of BoNT-A and swallowing treatment for oropharyngeal dysphagia recovery in a patient with Lateral Medullary Syndrome: a case study. ( 28264544 )
2017
4
Posterior inferior cerebellar artery susceptibility sign in lateral medullary syndrome. ( 28290427 )
2017
5
Neuroimaging "HINTS" of the Lateral Medullary Syndrome. ( 28471903 )
2017
6
Lateral medullary syndrome after a scorpion sting. ( 29026772 )
2017
7
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. ( 28488638 )
2017
8
Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye. ( 28769139 )
2017
9
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( 27461339 )
2016
10
Wallenberg's lateral medullary syndrome in an adolescent. ( 27246963 )
2016
11
Erratum to: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( 27716174 )
2016
12
Ipsilateral Facial Tactile Hypesthesia in a Patient with Lateral Medullary Syndrome. ( 26350694 )
2015
13
Ipsipulsion: A forgotten sign of lateral medullary syndrome. ( 26425003 )
2015
14
Subjective visual vertical and horizontal abnormalities in a patient with lateral medullary syndrome-a case report. ( 25745615 )
2015
15
Lateral medullary syndrome: a diagnostic approach illustrated through case presentation and literature review. ( 24626124 )
2014
16
Persistent hiccups (singultus) as the presenting symptom of lateral medullary syndrome. ( 25035568 )
2014
17
Opalski syndrome: a variant of lateral-medullary syndrome. ( 22608536 )
2013
18
An unexpected Holter monitor result: multiple sinus arrests in a patient with lateral medullary syndrome. ( 23386489 )
2013
19
Opalski's syndrome: A rare variant of lateral medullary syndrome. ( 23546377 )
2013
20
Variant lateral medullary syndrome in a patient presenting with inability to swallow. ( 23983892 )
2013
21
Hemi-seesaw nystagmus in lateral medullary syndrome. ( 23446678 )
2013
22
Lateral medullary syndrome: a diagnostic approach illustrated through case presentation and literature review. ( 23870801 )
2013
23
Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia. ( 22449744 )
2012
24
Varicella zoster vasculopathy presenting as lateral medullary syndrome. ( 23070818 )
2012
25
Up-down asymmetry of saccadic contrapulsion in lateral medullary syndrome. ( 22790667 )
2012
26
Lateral medullary syndrome due to brain stem tuberculoma. ( 21751596 )
2011
27
Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report. ( 21210329 )
2010
28
Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. ( 19828479 )
2010
29
Sudden death in a case of lateral medullary syndrome. ( 19439870 )
2009
30
Lateral medullary syndrome presenting with ataxia and bradycardia. ( 19534348 )
2009
31
Lateral medullary syndrome with anti-neuronal antibodies (anti-Ta/Ma2) in primary Sjogren's syndrome. ( 19620208 )
2009
32
Lateral medullary syndrome and ipsilateral hemiplegia (Opalski syndrome) due to left vertebral artery dissection. ( 20008668 )
2009
33
Incomplete lateral medullary syndrome in a patient with Chiari malformation Type I presenting with combined trigeminal and vagal nerve dysfunction. ( 18831657 )
2008
34
Stridor: an unusual presentation of lateral medullary syndrome. ( 17367563 )
2007
35
Lateral medullary syndrome in a woman after ovulation induction. ( 17344003 )
2007
36
Paroxysmal sneezing at the onset of lateral medullary syndrome: cause or consequence? ( 17388999 )
2007
37
Skull base osteomyelitis leading to lateral medullary syndrome in a child. ( 17258480 )
2007
38
Pontomedullary sulcus infarct: a variant of lateral medullary syndrome. ( 17043294 )
2006
39
Vestibular assessment in a patient with confirmed lateral medullary syndrome. ( 16371169 )
2006
40
Lateral medullary syndrome caused by penetrating head injury. ( 16914313 )
2006
41
Thrombolysis in a case of lateral medullary syndrome: CT angiographic findings. ( 15824352 )
2005
42
An atypic herpes encephalitis with Wallenberg's lateral medullary syndrome and CD receptors deficiency. ( 15168883 )
2004
43
Rapidly progressive fatal respiratory failure (Ondine's curse) in the lateral medullary syndrome. ( 17903948 )
2004
44
Wallenberg's lateral medullary syndrome: diffusion-weighted imaging findings. ( 15164784 )
2004
45
Fibromuscular dysplasia of the vertebral artery presenting with lateral medullary syndrome: a case report. ( 15666696 )
2004
46
Relapsing polychondritis with involvement of posterior inferior cerebellar artery causing acute lateral medullary syndrome. ( 17041437 )
2003
47
Lateral medullary syndrome after prone position for general surgery. ( 12401643 )
2002
48
Wallenberg's lateral medullary syndrome. ( 12415087 )
2002
49
Dysphagia in a patient with lateral medullary syndrome: insight into the central control of swallowing. ( 11487551 )
2001
50
CT study of closure of the hemipharynx with head rotation in a case of lateral medullary syndrome. ( 10594254 )
2000

Variations for Lateral Medullary Syndrome

Expression for Lateral Medullary Syndrome

Search GEO for disease gene expression data for Lateral Medullary Syndrome.

Pathways for Lateral Medullary Syndrome

GO Terms for Lateral Medullary Syndrome

Cellular components related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 APOH ATP4A FGB LEP PF4 PLG
2 cell surface GO:0009986 9.65 APOH CD22 CR1 FGB PLG
3 extracellular exosome GO:0070062 9.61 APOH CANX CD19 CD22 CR1 CR2
4 platelet alpha granule lumen GO:0031093 9.33 FGB PF4 PLG
5 collagen-containing extracellular matrix GO:0062023 9.02 APOH FGB PF4 PLG PRTN3

Biological processes related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of complement activation GO:0030449 9.63 CD19 CR1 CR2
2 fibrinolysis GO:0042730 9.49 FGB PLG
3 cellular sodium ion homeostasis GO:0006883 9.48 ATP12A ATP4A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.4 ATP12A ATP4A
6 complement receptor mediated signaling pathway GO:0002430 9.37 CR1 CR2
7 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
8 plasminogen activation GO:0031639 9.26 APOH FGB
9 cellular response to leptin stimulus GO:0044320 9.16 FGB LEP
10 negative regulation of fibrinolysis GO:0051918 8.96 APOH PLG
11 platelet degranulation GO:0002576 8.92 APOH FGB PF4 PLG

Molecular functions related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 CD22 FGB LEP PLG PRTN3
2 apolipoprotein binding GO:0034185 9.26 CANX PLG
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Lateral Medullary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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