MCID: LTR003
MIFTS: 41

Lateral Medullary Syndrome

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lateral Medullary Syndrome

MalaCards integrated aliases for Lateral Medullary Syndrome:

Name: Lateral Medullary Syndrome 12 53 54 44 15 17 72
Posterior Inferior Cerebellar Artery Syndrome 12 53
Vertebral Artery Syndrome 53 72
Wallenberg's Syndrome 53 54
Wallenberg Syndrome 12 53
Pica Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3522
MeSH 44 D014854
NCIt 50 C84807
SNOMED-CT 68 78569004
ICD10 33 G46.3
UMLS 72 C0043019 C2931914

Summaries for Lateral Medullary Syndrome

NINDS : 54 Wallenberg’s syndrome is a neurological condition caused by a stroke in the vertebral or posterior inferior cerebellar artery of the brain stem. Symptoms include difficulties with swallowing, hoarseness, dizziness, nausea and vomiting, rapid involuntary movements of the eyes (nystagmus), and problems with balance and gait coordination. Some individuals will experience a lack of pain and temperature sensation on only one side of the face, or a pattern of symptoms on opposite sides of the body – such as paralysis or numbness in the right side of the face, with weak or numb limbs on the left side. Uncontrollable hiccups may also occur, and some individuals will lose their sense of taste on one side of the tongue, while preserving taste sensations on the other side. Some people with Wallenberg’s syndrome report that the world seems to be tilted in an unsettling way, which makes it difficult to keep their balance when they walk.

MalaCards based summary : Lateral Medullary Syndrome, also known as posterior inferior cerebellar artery syndrome, is related to brain stem infarction and aspiration pneumonia, and has symptoms including vertigo, ipsilateral cerebellar signs and contralateral sensory deficits of limbs. An important gene associated with Lateral Medullary Syndrome is FGB (Fibrinogen Beta Chain), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include brain, medulla oblongata and eye.

Disease Ontology : 12 A brain stem infarction that is characterized by hoarseness, dizziness, nausea, located in the lateral part of the medulla oblongata that develops from a blockage in the posterior inferior cerebellar artery or one of its branches or of the vertebral artery, has symptom vertigo, has symptom ipsilateral cerebellar signs, has symptom contralateral sensory deficits of limbs and torso, has symptom ipsilateral sensory deficits of face, has symptom laryngeal, pharyngeal, and palatal hemiparalysis, has symptom ipsilateral Horner's syndrome.

NIH Rare Diseases : 53 Wallenberg syndrome is a condition that affects the nervous system. Signs and symptoms may include swallowing difficulties, dizziness, hoarseness, nausea and vomiting, nystagmus, and problems with balance. Some people have uncontrollable hiccups, loss of pain and temperature sensation on one side of the face, and/or weakness or numbness on one side of the body. Wallenberg syndrome is often caused by a stroke in the brain stem. Treatment addresses each symptom and may include a feeding tube for swallowing problems, speech and/or swallowing therapy, and medication for pain. While some people's symptoms may improve within weeks or months, others may have long-term neurological problems.

Wikipedia : 75 Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the... more...

Related Diseases for Lateral Medullary Syndrome

Diseases related to Lateral Medullary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 brain stem infarction 30.7 PLG FGB
2 aspiration pneumonia 30.1 ATP4A ATP12A
3 systemic lupus erythematosus 28.6 PRTN3 CR2 CR1 CD19 APOH
4 vertebral artery insufficiency 11.8
5 parapharyngeal meningioma 10.7 CR2 CR1
6 interdigitating dendritic cell sarcoma 10.7 CR2 CR1
7 langerhans cell sarcoma 10.7 CR2 CR1
8 t-cell/histiocyte rich large b cell lymphoma 10.7 CR2 CR1
9 histiocytic and dendritic cell cancer 10.7 CR2 CR1
10 central nervous system leukemia 10.6 CR1 CD19
11 immunodeficiency, common variable, 2 10.6 CR2 CD19
12 reticulum cell sarcoma 10.6 CR2 CR1
13 lobomycosis 10.6 CR2 CD19
14 bladder lymphoma 10.6 CR2 CD19
15 waldenstroem's macroglobulinemia 10.5 CD22 CD19
16 colon lymphoma 10.5 CD22 CD19
17 dendritic cell tumor 10.5 CR2 CR1
18 fungal esophagitis 10.5 ATP4A ATP12A
19 gastroduodenal crohn's disease 10.5 ATP4A ATP12A
20 diclofenac allergy 10.5 ATP4A ATP12A
21 neonatal candidiasis 10.5 ATP4A ATP12A
22 squamous papillomatosis 10.5 ATP4A ATP12A
23 photoallergic dermatitis 10.5 ATP4A ATP12A
24 gastrointestinal neuroendocrine benign tumor 10.5 ATP4A ATP12A
25 aspiration pneumonitis 10.5 ATP4A ATP12A
26 toxic megacolon 10.5 ATP4A ATP12A
27 gastric antral vascular ectasia 10.4 ATP4A ATP12A
28 acute laryngitis 10.4 ATP4A ATP12A
29 laryngitis 10.4 ATP4A ATP12A
30 gastric neuroendocrine neoplasm 10.4 ATP4A ATP12A
31 esophageal candidiasis 10.4 ATP4A ATP12A
32 duodenitis 10.4 ATP4A ATP12A
33 active peptic ulcer disease 10.4 ATP4A ATP12A
34 rumination disorder 10.4 ATP4A ATP12A
35 dyskinesia of esophagus 10.4 ATP4A ATP12A
36 peptic esophagitis 10.4 ATP4A ATP12A
37 capillary disease 10.4 ATP4A ATP12A
38 bile reflux 10.4 ATP4A ATP12A
39 ischemic neuropathy 10.4 ATP4A ATP12A
40 bladder calculus 10.4 ATP4A ATP12A
41 congenital disorder of deglycosylation 10.4 ATP4A ATP12A
42 anismus 10.4 ATP4A ATP12A
43 hernia, hiatus 10.4 ATP4A ATP12A
44 postsurgical hypothyroidism 10.4 ATP4A ATP12A
45 esophageal atresia/tracheoesophageal fistula 10.4 ATP4A ATP12A
46 lymphocytic colitis 10.4 ATP4A ATP12A
47 dysphagia 10.4
48 clostridium difficile colitis 10.4 ATP4A ATP12A
49 esophagitis, eosinophilic, 1 10.4 ATP4A ATP12A
50 diarrhea 1, secretory chloride, congenital 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Lateral Medullary Syndrome:



Diseases related to Lateral Medullary Syndrome

Symptoms & Phenotypes for Lateral Medullary Syndrome

Symptoms:

12
  • vertigo
  • ipsilateral cerebellar signs
  • contralateral sensory deficits of limbs
  • ipsilateral sensory deficits of face
  • laryngeal
  • ipsilateral horner's syndrome

Drugs & Therapeutics for Lateral Medullary Syndrome

Search Clinical Trials , NIH Clinical Center for Lateral Medullary Syndrome

Cochrane evidence based reviews: lateral medullary syndrome

Genetic Tests for Lateral Medullary Syndrome

Anatomical Context for Lateral Medullary Syndrome

MalaCards organs/tissues related to Lateral Medullary Syndrome:

41
Brain, Medulla Oblongata, Eye, Tongue, Testes, Cortex, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Lateral Medullary Syndrome:

19
Lateral Part Of The Medulla Oblongata

Publications for Lateral Medullary Syndrome

Articles related to Lateral Medullary Syndrome:

(show top 50) (show all 441)
# Title Authors PMID Year
1
Lateral medullary syndrome due to brain stem tuberculoma. 38 6
21751596 2011
2
Wallenberg syndrome caused by multiple sclerosis mimicking stroke. 38 6
19800798 2009
3
Lateral medullary syndrome caused by penetrating head injury. 38 6
16914313 2006
4
Lateral medullary syndrome following varicella infection. 38 6
8352215 1993
5
Fatal Progression of Gorham-Stout Disease with Skull Base Osteomyelitis and Lateral Medullary Syndrome. 38
30799352 2019
6
A case of varicella zoster encephalitis with glossopharyngeal and vagus nerve injury as primary manifestation combined with medulla lesion. 38
30880528 2019
7
Lateral medullary infarction with cardiovascular autonomic dysfunction: an unusual presentation with review of the literature. 38
29368226 2018
8
Fine margin between crossed sensory and contralateral sensory loss: A case report. 38
29937417 2018
9
False-negative diagnostic imaging of Wallenberg's syndrome by diffuse-weighted imaging: a case report and literature review. 38
29627941 2018
10
Utility of thermographic measurements of laterality of body surface temperature to prevent misdiagnosis of acute Wallenberg's syndrome. 38
29993195 2018
11
Vertebral Artery Occlusion Causing Facial Colliculus and Opalski Stroke Syndromes Simultaneously. 38
29722745 2018
12
Case report: Wallenberg's syndrome, a possible cause of symptomatic epicrania fugax. 38
28786694 2018
13
Vertebral artery dissection stroke in evolution presented with postural headache as initial manifestation. 38
30069291 2018
14
Brain Stem Ischemic Stroke Associated with Anaphylaxis. 38
29744255 2018
15
[Trigeminal Herpes Zoster Presenting with High-intensity Signals for the Spinal Trigeminal Nucleus and Tract on Diffusion-weighted Image: A Case Report of Stroke Mimic]. 38
29433118 2018
16
Reversible drug-induced antiphospholipid syndrome. 38
28592198 2018
17
Lateral medullary syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study. 38
29217256 2018
18
Clinical course and outcome in patients with severe dysphagia after lateral medullary syndrome. 38
29511384 2018
19
Double conduction through the atrioventricular node following acute medullary infarction: a case report. 38
29404361 2018
20
Sarcoidosis presenting as Wallenberg syndrome and panuveitis. 38
29977748 2018
21
Neuroimaging "HINTS" of the Lateral Medullary Syndrome. 38
28471903 2017
22
Efficacy of botulinum toxin type-A and swallowing treatment for oropharyngeal dysphagia recovery in a patient with lateral medullary syndrome. 38
28264544 2017
23
After Effects of Cerebellar Continuous Theta Burst Stimulation on Reflexive Saccades and Smooth Pursuit in Humans. 38
28303385 2017
24
Crossed cheiro-oral syndrome: A warning sign for medullary involvement and neurological deterioration. 38
28089423 2017
25
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. 38
28488638 2017
26
Progressive Bilateral Vertebral Artery Dissection in a Case of Osteogenesis Imperfecta. 38
28089253 2017
27
Posterior inferior cerebellar artery susceptibility sign in lateral medullary syndrome. 38
28290427 2017
28
Treatment of Wallenberg's Syndrome related dysphagia with pyridostigmine. 38
27424039 2017
29
Lateral medullary syndrome after a scorpion sting. 38
29026772 2017
30
Transient Vestibulopathy in Wallenberg's Syndrome: Pathologic Analysis. 38
28567027 2017
31
Pacemaker Placement in Patients with Stroke-Mediated Autonomic Dysregulation. 38
28400822 2017
32
Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye. 38
28769139 2017
33
Wallenberg's lateral medullary syndrome in an adolescent. 38
27246963 2016
34
Erratum to: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. 38
27716174 2016
35
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. 38
27461339 2016
36
The Lurking Catastrophic Complication of an Equally Catastrophic Disease: The Lesson Learned. 38
29506097 2016
37
[Neuroanatomy of Isolated Body Lateropulsion]. 38
27001775 2016
38
Two young stroke patients associated with regular intravenous immunoglobulin (IVIg) therapy. 38
26810508 2016
39
Ipsilateral Facial Tactile Hypesthesia in a Patient with Lateral Medullary Syndrome. 38
26350694 2015
40
Repeated Transient Wallenberg's Syndrome: Probable Association with Ipsilateral Vertebral Artery Hypoplasia and Aortic Valve Disease. 38
26123876 2015
41
Ipsipulsion: A forgotten sign of lateral medullary syndrome. 38
26425003 2015
42
Subjective visual vertical and horizontal abnormalities in a patient with lateral medullary syndrome-a case report. 38
25745615 2015
43
Survival in fully manifest multiple organ dysfunction syndrome. 38
24450728 2014
44
Persistent hiccups (singultus) as the presenting symptom of lateral medullary syndrome. 38
25035568 2014
45
A Rare Variant of Wallenberg's Syndrome: Opalski syndrome. 38
25177595 2014
46
Lateral medullary syndrome: a diagnostic approach illustrated through case presentation and literature review. 38
24626124 2014
47
[Central respiratory failure occurred in the subacute phase of unilateral Wallenberg's syndrome: a case report]. 38
24807272 2014
48
Fenestration and duplication of the vertebral artery: the anatomical and clinical points of view. 38
23553773 2013
49
Opalski syndrome: a variant of lateral-medullary syndrome. 38
22608536 2013
50
Variant lateral medullary syndrome in a patient presenting with inability to swallow. 38
23983892 2013

Variations for Lateral Medullary Syndrome

Expression for Lateral Medullary Syndrome

Search GEO for disease gene expression data for Lateral Medullary Syndrome.

Pathways for Lateral Medullary Syndrome

GO Terms for Lateral Medullary Syndrome

Cellular components related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 PRTN3 PLG PF4 LEP FGB ATP4A
2 cell surface GO:0009986 9.65 PLG FGB CR1 CD22 APOH
3 extracellular exosome GO:0070062 9.61 PRTN3 PLG FGB CR2 CR1 CD22
4 platelet alpha granule lumen GO:0031093 9.33 PLG PF4 FGB
5 collagen-containing extracellular matrix GO:0062023 9.02 PRTN3 PLG PF4 FGB APOH

Biological processes related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.7 PRTN3 PLG FGB
2 regulation of complement activation GO:0030449 9.63 CR2 CR1 CD19
3 ATP hydrolysis coupled proton transport GO:0015991 9.51 ATP4A ATP12A
4 fibrinolysis GO:0042730 9.49 PLG FGB
5 cellular sodium ion homeostasis GO:0006883 9.48 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP4A ATP12A
7 sodium ion export across plasma membrane GO:0036376 9.4 ATP4A ATP12A
8 complement receptor mediated signaling pathway GO:0002430 9.37 CR2 CR1
9 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
10 plasminogen activation GO:0031639 9.26 FGB APOH
11 negative regulation of fibrinolysis GO:0051918 9.16 PLG APOH
12 cellular response to leptin stimulus GO:0044320 8.96 LEP FGB
13 platelet degranulation GO:0002576 8.92 PLG PF4 FGB APOH

Molecular functions related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 PRTN3 PLG LEP FGB CD22
2 apolipoprotein binding GO:0034185 9.26 PLG CANX
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Lateral Medullary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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