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MCID: LTX001
MIFTS: 42

Latex Allergy

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Latex Allergy

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MalaCards integrated aliases for Latex Allergy:

Name: Latex Allergy 12 55 43 15 72

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060532
UMLS 72 C0577628
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Summaries for Latex Allergy

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MedlinePlus : 43 Latex is a milky fluid that comes from the tropical rubber tree. Hundreds of everyday products contain latex. Repeated exposure to a protein in natural latex can make you more likely to develop a latex allergy. If your immune system detects the protein, a reaction can start in minutes. You could get a rash or asthma. In rare cases you could have a severe reaction called anaphylaxis. Your doctor may use a physical exam and skin and blood tests to diagnose it. There are medicines to treat a reaction, but it is best to try to avoid latex. Common latex products include Gloves Condoms Balloons Rubber bands Shoe soles Pacifiers You can find latex-free versions of these products.

MalaCards based summary : Latex Allergy is related to pollen allergy and penicillin allergy, and has symptoms including exanthema An important gene associated with Latex Allergy is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dinoprostone and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and spinal cord, and related phenotype is digestive/alimentary.

Disease Ontology : 12 A hypersensitivity reaction type I disease triggered by latex.

Wikipedia : 75 Latex allergy is a medical term encompassing a range of allergic reactions to the proteins present in... more...

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Related Diseases for Latex Allergy

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Diseases related to Latex Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 30.4 RNASE3 IL5 IL13
2 penicillin allergy 30.4 IL4 IL13
3 contact dermatitis 30.4 IL5 IL4 FLG
4 conjunctivitis 30.3 RNASE3 IL5 IL4 IL13
5 status asthmaticus 30.3 RNASE3 IL5
6 ige responsiveness, atopic 30.2 RNASE3 IL5 IL4 IL13 IGHE
7 allergic hypersensitivity disease 30.1 RNASE3 IL5 IL4 IL13 IGHE
8 exercise-induced anaphylaxis 30.1 IGHE FLG
9 allergic contact dermatitis 30.1 IL5 IL4 FLG
10 recurrent respiratory papillomatosis 30.0 HLA-DRB1 HLA-DQB1
11 rhinitis 30.0 RNASE3 IL5 IL4 IL13 IGHE
12 hypereosinophilic syndrome 29.3 RNASE3 IL5 IL4 IL13 IGHE
13 pulmonary eosinophilia 29.3 RNASE3 IL5 IL4 IL13
14 allergic conjunctivitis 29.3 RNASE3 IL5 IL4 IL13
15 food allergy 29.2 RNASE3 IL5 IL4 IL13 FLG
16 allergic rhinitis 29.1 RNASE3 IL5 IL4 IL18 IL13 IGHE
17 dermatitis 28.9 IL5 IL4 IL18 IL13 IGHE FLG
18 allergic asthma 28.8 RNASE3 IL5 IL4 IL13 IGHE
19 skin disease 28.6 RNASE3 IL5 IL4 IL13 FLG
20 dermatitis, atopic 28.0 RNASE3 IL5 IL4 IL18 IL13 IGHE
21 asthma 26.0 RNASE3 IL5 IL4 IL18 IL13 IGHE
22 neural tube defects 11.8
23 myelomeningocele 11.7
24 meningocele 11.4
25 urticaria 10.9
26 angioedema 10.6
27 exanthem 10.5
28 mercury poisoning 10.5 IL18 IL13
29 cytokine deficiency 10.5 IL5 IL13
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 IL13
31 respiratory syncytial virus infectious disease 10.5 IL5 IL13
32 fruit allergy 10.5
33 strongyloidiasis 10.4 IL5 IL13
34 cysticercosis 10.4 IL18 IGHE
35 toxocariasis 10.4 RNASE3 IGHE
36 esophagitis, eosinophilic, 1 10.4 IL5 IL13
37 ascaris lumbricoides infection 10.4 IL5 IL13
38 loeffler endocarditis 10.4 RNASE3 IL5
39 radiculopathy 10.4 IL5 IL13
40 cow milk allergy 10.4 RNASE3 IL5
41 beta-lactam allergy 10.3 IL4 IL13
42 immunodeficiency with hyper-igm, type 1 10.3 IL4 IGHE
43 eosinophilic gastroenteritis 10.3 RNASE3 IL5
44 pemphigoid gestationis 10.3 IL5 HLA-DRB1
45 actinic prurigo 10.3 IL13 HLA-DRB1
46 chronic eosinophilic pneumonia 10.3 RNASE3 IL5
47 scleritis 10.3 IL5 IL4
48 irritant dermatitis 10.3
49 hyper ige syndrome 10.3 IL4 IGHE
50 night blindness, congenital stationary, type 1a 10.3 IL5 IL13

Graphical network of the top 20 diseases related to Latex Allergy:



Diseases related to Latex Allergy
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Symptoms & Phenotypes for Latex Allergy

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UMLS symptoms related to Latex Allergy:


exanthema

MGI Mouse Phenotypes related to Latex Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 HLA-DQB1 IL13 IL18 IL4 IL5
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Drugs & Therapeutics for Latex Allergy

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Drugs for Latex Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
Misoprostol Approved Phase 4 59122-46-2 5282381
3 Hormones Phase 4
4 Gastrointestinal Agents Phase 4
5 Antacids Phase 4
6 Oxytocics Phase 4
7 Anti-Ulcer Agents Phase 4
8
Cocaine Approved, Illicit 50-36-2 446220 5760
9
tannic acid Approved 1401-55-4
10
Lidocaine Approved, Vet_approved 137-58-6 3676
11
Epinephrine Approved, Vet_approved 51-43-4 5816
12
Racepinephrine Approved 329-65-7 838
13
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
14
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
15 Epinephryl borate
16 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Cervical Ripening Balloon in Induction of Labour at Term (CRBII) - A Prospective Randomized Controlled Trial Completed NCT02620215 Phase 4 Prostin
2 Foley Bulb With Oral Misoprostol Versus Oral Misoprostol for Induction of Labor: A Cluster Randomized Trial Active, not recruiting NCT03407625 Phase 4
3 Safety, Efficacy, and Patient Satisfaction of Cervical Ripening With Transcervical Use of the Foley Catheter in an Outpatient Setting Unknown status NCT01605474
4 Switching to Powder Free Latex Gloves in the Entire OR as Part of a New ' Latex Safe' Protocol: a Safe Alternative? A Prospective, Observational Cohort Study Completed NCT02575053
5 The Effect of Pelvic Floor Muscle Training on the Quality of Life and Functionality in Women With Urinary Incontinence: a Randomized Controlled Trial Completed NCT03514147
6 The Comparison Of The Efficacy Of Three Methods Applied During Venous Blood Sampling On Reducing Pain And Fear In Children Completed NCT03720808
7 TranQuillâ„¢ Sling Snoreplasty for Snoring and Mild Obstructive Sleep Apnea: A Single-arm, Pilot Study for Safety and Effectiveness Completed NCT02364518
8 Comparison of Pre-Induction Cervical Ripening Using Prepidil Gel Administered Through a Urinary Balloon Catheter. Completed NCT01390233 Prepidil Gel
9 Obstructive Sleep Apnea Among Pregnant Women With Chronic Hypertension Recruiting NCT03230110
10 Effectiveness of Pelvic Floor Muscles Training in Group for Women With Urinary Incontinence: a Randomized Clinical Test Active, not recruiting NCT03500185
11 Prevalence of High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing. Reversibility After Treatment (The Kids TRIAL STUDY). Not yet recruiting NCT03696654
12 Yulex Glove Prospective Study Terminated NCT01133288

Search NIH Clinical Center for Latex Allergy

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Genetic Tests for Latex Allergy

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Anatomical Context for Latex Allergy

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MalaCards organs/tissues related to Latex Allergy:

41
Testes, Skin, Spinal Cord, B Cells, T Cells, Heart, Eye
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Publications for Latex Allergy

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Articles related to Latex Allergy:

(show top 50) (show all 1431)
# Title Authors PMID Year
1
Profile Shift in Latex Sensitization over the Last 20 Years. 38 17
30212836 2019
2
Latex hypersensitivity to injection devices for biologic therapies in psoriasis patients. 38 17
30235360 2018
3
Manifestation of intraoperative anaphylactic shock along with latex allergy:a pediatric case report. 38 17
30282877 2018
4
Component-resolved diagnosis from latex allergy by microarray. 9 38
20210809 2010
5
Interference of cross-reactive carbohydrates in the determination of specific IgE in alcohol drinkers and strategies to minimize it: the example of latex. 9 38
18939728 2008
6
Latex allergy: low prevalence of immunoglobulin E to highly purified proteins Hev b 2 and Hev b 13. 9 38
17850383 2007
7
Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. 9 38
15731584 2005
8
Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum. 9 38
15725197 2005
9
Prevalence of evaluation for latex allergy and association with practice characteristics in United States dermatologists: results of a cross-sectional survey. 9 38
11526518 2001
10
Assessment of IgE allergen specificity among latex-allergic health care workers: review of IgE-binding components of various latex extracts. 9 38
11152171 2000
11
Latex allergy in the workplace. 9 38
11053535 2000
12
[A case of latex allergy with bronchial asthma]. 9 38
11193320 2000
13
Latex allergy in children on home mechanical ventilation. 9 38
11035669 2000
14
Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy. 9 38
11275264 2000
15
Prevention of latex allergy by selection of low-allergen gloves. 9 38
10718848 2000
16
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy. 9 38
9802376 1998
17
Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy. 9 38
9756201 1998
18
[Latex allergy in health services workers]. 9 38
9825659 1998
19
IgE from latex-allergic patients binds to cloned and expressed B cell epitopes of prohevein. 9 38
9548517 1997
20
Natural rubber latex allergy in children who had not undergone surgery and children who had undergone multiple operations. 9 38
9389289 1997
21
Natural latex, grass pollen, and weed pollen share IgE epitopes. 9 38
9314348 1997
22
Prevalence of latex-specific IgE antibodies in atopic and nonatopic children with type I diabetes. 9 38
9096963 1997
23
A nurse with anaphylaxis to stone fruits and latex sensitivity: potential diagnostic difficulties to consider. 9 38
8970444 1996
24
Latex allergy: allergen identification in Hevea braziliensis fractions by immunoblotting. 9 38
8911704 1996
25
Comparison of latex-specific IgE binding among nonammoniated latex, ammoniated latex, and latex glove allergenic extracts by ELISA and immunoblot inhibition. 9 38
8626990 1996
26
A two-dimensional electrophoretic analysis of latex peptides reacting with IgE and IgG antibodies from patients with latex allergy. 9 38
8527952 1996
27
Cross-reacting allergens in natural rubber latex and avocado. 9 38
7636053 1995
28
Banana allergy in patients with immediate-type hypersensitivity to natural rubber latex: characterization of cross-reacting antibodies and allergens. 9 38
8006321 1994
29
Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex proteins in patients with spina bifida and histories of anaphylaxis. 9 38
8195677 1994
30
Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources. 9 38
8145008 1994
31
Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. 9 38
8509575 1993
32
Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy. 9 38
1587468 1992
33
Allergy topics for dental practitioners. 38
31355763 2019
34
Effect of intravaginal vibratory versus electric stimulation on the pelvic floor muscles: A randomized clinical trial. 38
31403114 2019
35
Allergen-specific IgE to recombinant latex allergens in occupational allergy diagnostics. 38
31090202 2019
36
Safety of a powder-free latex allergy protocol in the operating theatre: A prospective, observational cohort study. 38
30817368 2019
37
Anorectal physiology in health: A randomized trial to determine the optimum catheter for the balloon expulsion test. 38
30703851 2019
38
Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing-Design and rationale. 38
30393915 2019
39
Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies. 38
30976286 2019
40
Latex Allergy Risks Live On. 38
30249547 2018
41
Spontaneous disappearance of severe latex allergy in an adult. 38
30618228 2018
42
Knowledge and Awareness towards Occupational Hazards and Preventive Measures among Students and Dentists in Jazan Dental College, Saudi Arabia. 38
30337998 2018
43
Latex Allergy and Occupational Exposure: The Patient's Perspective. 38
30073963 2018
44
Anaphylaxis triggered by prick test with latex extract: a case report. 38
29898012 2018
45
Latex sensitization in patients with myelomeningocele: contribution of microarray technique. 38
29479928 2018
46
Safety of a condom uterine balloon tamponade (ESM-UBT) device for uncontrolled primary postpartum hemorrhage among facilities in Kenya and Sierra Leone. 38
29764416 2018
47
[Latex sensitization and allergy in Hospital General de Mexico surgery residents]. 38
29983010 2018
48
Latex immunotherapy: evidence of effectiveness. 38
29760613 2018
49
Piperacillin-tazobactam anaphylaxis: a rare cause of occupational disease. 38
29383926 2018
50
Fecal incontinence in patients with spina bifida: The target is the rectum. 38
28950040 2018
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Variations for Latex Allergy

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Expression for Latex Allergy

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Search GEO for disease gene expression data for Latex Allergy.
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Pathways for Latex Allergy

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Pathways related to Latex Allergy according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.77 RNASE3 IL5 IL4 IL18 IL13 IGHE
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.06 IL5 IL4 IL18 IL13 IGHE HLA-DRB1
3
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.43 IL5 IL4 IL13 IGHE
4
Immune response NFAT in immune response 22
Show member pathways
 12.43 IL4 IL18 IGHE HLA-DRB1 HLA-DQB1
5
Th17 cell differentiation 37
Show member pathways
 12.27 IL5 IL4 IL18 IL13 HLA-DRB1 HLA-DQB1
6
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.19 IL5 IL4 IL13
7
IL-17 Family Signaling Pathways 65
Show member pathways
 12.15 IL5 IL4 IL13
8
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.12 IL5 IL4 IL18 IL13
9
Toxoplasmosis 37
Show member pathways
 12.08 IL4 HLA-DRB1 HLA-DQB1
10
Tuberculosis 37
12.06 IL18 HLA-DRB1 HLA-DQB1
11
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.93 IL5 IL4 IL18 IL13
12
Allograft rejection 37 1
Show member pathways
 11.91 RNASE3 IL5 IL4 IL18 IL13 HLA-DRB1
13
IL12-mediated signaling events 1
Show member pathways
 11.85 IL4 IL18 HLA-DRB1
14
Interleukin-4 and 13 signaling 66
11.79 IL4 IL18 IL13 IGHE
15
Rheumatoid arthritis 37
11.74 IL18 HLA-DRB1 HLA-DQB1
16
Glucocorticoid receptor regulatory network 1
11.67 IL5 IL4 IL13
17
Hematopoietic cell lineage 37
11.66 IL5 IL4 HLA-DRB1 HLA-DQB1
18
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.59 IL4 IL18 IL13
19
Lung fibrosis 1
11.53 IL5 IL4 IL13
20
Innate Lymphoid Cell Differentiation Pathways 65
11.53 IL5 IL4 IL18 IL13
21
IL4-mediated signaling events 1
11.52 IL5 IL4 IGHE
22
Interleukin-10 signaling 66
11.4 IL4 IL18 IL13
23
Th2 Differentiation Pathway 65
11.36 IL5 IL4 IL13
24
Inflammatory Response Pathway 1
11.16 IL5 IL4
25
IL12 signaling mediated by STAT4 1
11.12 IL18 IL13 HLA-DRB1
26
OX40 Pathway 64
11.05 IL5 IL4 IL13
27
G-protein signaling_RhoB regulation pathway 22
11.04 IL5 IL4 IL18 IL13
28
Development and heterogeneity of the ILC family 1
10.96 IL5 IL4 IL18 IL13
29
G-protein signaling_Rap2B regulation pathway 22
10.83 IL5 IL4 IL18 IL13
30
Cytokines and Inflammatory Response 1
10.72 IL5 IL4 IL13 HLA-DRB1
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GO Terms for Latex Allergy

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Cellular components related to Latex Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 RNASE3 IL5 IL4 IL18 IL13 IGHE
2 transport vesicle membrane GO:0030658 9.32 HLA-DRB1 HLA-DQB1
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRB1 HLA-DQB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB1 HLA-DQB1
5 MHC class II protein complex GO:0042613 8.62 HLA-DRB1 HLA-DQB1

Biological processes related to Latex Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.63 IL4 IL18 IL13
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 IL4 IL18 IL13
3 antigen processing and presentation GO:0019882 9.52 HLA-DRB1 HLA-DQB1
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.51 IL4 IL13
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.49 HLA-DRB1 HLA-DQB1
6 T-helper 1 type immune response GO:0042088 9.48 IL18 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DRB1 HLA-DQB1
8 type 2 immune response GO:0042092 9.37 IL4 IL18
9 cytokine-mediated signaling pathway GO:0019221 9.35 IL5 IL4 IL18 IL13 IGHE
10 positive regulation of B cell proliferation GO:0030890 9.33 IL5 IL4 IL13
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL4 IL13
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.26 HLA-DRB1 HLA-DQB1
13 immune response GO:0006955 9.17 IL5 IL4 IL18 IL13 IGHE HLA-DRB1

Molecular functions related to Latex Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.26 HLA-DRB1 HLA-DQB1
2 cytokine receptor binding GO:0005126 9.16 IL4 IL13
3 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQB1
4 cytokine activity GO:0005125 8.92 IL5 IL4 IL18 IL13
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Sources for Latex Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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