Aliases & Classifications for Latex Allergy

MalaCards integrated aliases for Latex Allergy:

Name: Latex Allergy 12 54 42 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060532
UMLS 71 C0577628

Summaries for Latex Allergy

MedlinePlus : 42 Latex is a milky fluid that comes from the tropical rubber tree. Hundreds of everyday products contain latex. Repeated exposure to a protein in natural latex can make you more likely to develop a latex allergy. If your immune system detects the protein, a reaction can start in minutes. You could get a rash or asthma. In rare cases you could have a severe reaction called anaphylaxis. Your doctor may use a physical exam and skin and blood tests to diagnose it. There are medicines to treat a reaction, but it is best to try to avoid latex. Common latex products include Gloves Condoms Balloons Rubber bands Shoe soles Pacifiers You can find latex-free versions of these products.

MalaCards based summary : Latex Allergy is related to pollen allergy and urticaria, and has symptoms including exanthema An important gene associated with Latex Allergy is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dinoprostone and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung, and related phenotype is digestive/alimentary.

Disease Ontology : 12 A hypersensitivity reaction type I disease triggered by latex.

Wikipedia : 74 Latex allergy is a medical term encompassing a range of allergic reactions to the proteins present in... more...

Related Diseases for Latex Allergy

Diseases related to Latex Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 30.8 RNASE3 IL5 IL13
2 urticaria 30.7 TNF RNASE3 IL5 IL4 IL13 IGHE
3 irritant dermatitis 30.5 TNF IL4 FLG
4 exercise-induced anaphylaxis 30.5 IGHE FLG
5 ige responsiveness, atopic 30.2 RNASE3 IL5 IL4 IL13 IGHE IGES
6 eosinophilic pneumonia 30.0 RNASE3 IL5 IL4 IL13
7 contact dermatitis 30.0 TNF IL5 IL4 IL18 IFNG FLG
8 allergic contact dermatitis 29.9 TNF IL5 IL4 IFNG FLG
9 conjunctivitis 29.7 TNF RNASE3 IL5 IL4 IL13 IGHE
10 penicillin allergy 29.5 IL4 IL18 IL13 IGHE IFNG
11 rhinitis 29.4 TNF RNASE3 IL5 IL4 IL13 IGHE
12 allergic rhinitis 29.3 RNASE3 IL5 IL4 IL18 IL13 IGHE
13 pulmonary eosinophilia 29.3 RNASE3 IL5 IL4 IL13 CCL3
14 hypereosinophilic syndrome 29.3 RNASE3 IL5 IL4 IL13 IGHE IGES
15 dermatitis 29.1 TNF RNASE3 IL5 IL4 IL18 IL13
16 food allergy 28.9 TNF RNASE3 IL5 IL4 IL13 IGHE
17 skin disease 28.7 TNF RNASE3 IL5 IL4 IL18 IL13
18 allergic conjunctivitis 28.7 TNF RNASE3 IL5 IL4 IL13 IGHE
19 allergic hypersensitivity disease 28.5 TNF RNASE3 IL5 IL4 IL13 IGHE
20 allergic asthma 28.2 RNASE3 IL5 IL4 IL18 IL13 IGHE
21 asthma 26.5 TNF RNASE3 IL5 IL4 IL18 IL13
22 dermatitis, atopic 26.4 TNF RNASE3 IL5 IL4 IL18 IL13
23 neural tube defects 11.8
24 myelomeningocele 11.7
25 meningocele 11.4
26 angioedema 10.6
27 exanthem 10.5
28 cytokine deficiency 10.5 IL5 IL13
29 mercury poisoning 10.5 IL18 IL13
30 aztreonam allergy 10.5 IL5 IL13
31 ceftriaxone allergy 10.5 IL5 IL13
32 fruit allergy 10.5
33 cefaclor allergy 10.5 IL5 IL13
34 cefuroxime allergy 10.4 IL5 IL13
35 loeffler syndrome 10.4 IL5 IL13
36 loeffler endocarditis 10.4 RNASE3 IL5
37 norwegian scabies 10.4 IL5 IL13
38 idiopathic nephrotic syndrome 10.4 IL4 IGHE
39 eosinophilic gastritis 10.4 IL5 IL13
40 orange allergy 10.4 IL5 IL13
41 anisakiasis 10.3 RNASE3 IGHE
42 systemic onset juvenile idiopathic arthritis 10.3 TNF IL18
43 adiposis dolorosa 10.3 IL13 CCL4
44 disseminated eosinophilic collagen disease 10.3 RNASE3 IL5
45 toxocariasis 10.3 RNASE3 IL5 IGHE
46 tropical endomyocardial fibrosis 10.3 TNF IL4
47 blepharoconjunctivitis 10.3 RNASE3 IL4
48 beryllium disease 10.3 TNF HLA-DQB1
49 eosinophilic fasciitis 10.3 IL5 IFNG
50 trichinosis 10.3 IL5 IL4 IL13

Graphical network of the top 20 diseases related to Latex Allergy:



Diseases related to Latex Allergy

Symptoms & Phenotypes for Latex Allergy

UMLS symptoms related to Latex Allergy:


exanthema

MGI Mouse Phenotypes related to Latex Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 HLA-DQB1 IFNG IL13 IL18 IL4 IL5

Drugs & Therapeutics for Latex Allergy

Drugs for Latex Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
Misoprostol Approved Phase 4 59122-46-2 5282381
3 Hormones Phase 4
4 Gastrointestinal Agents Phase 4
5 Anti-Ulcer Agents Phase 4
6 Oxytocics Phase 4
7 Antacids Phase 4
8
Cocaine Approved, Illicit 50-36-2 5760 446220
9
Epinephrine Approved, Vet_approved 51-43-4 5816
10
tannic acid Approved 1401-55-4
11
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
12
Lidocaine Approved, Vet_approved 137-58-6 3676
13
Racepinephrine Approved 329-65-7 838
14
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
15 Epinephryl borate
16 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Cervical Ripening Balloon in Induction of Labour at Term (CRBII) - A Prospective Randomized Controlled Trial Completed NCT02620215 Phase 4 Prostin
2 Foley Bulb With Oral Misoprostol Versus Oral Misoprostol for Induction of Labor: A Cluster Randomized Trial Active, not recruiting NCT03407625 Phase 4
3 Safety, Efficacy, and Patient Satisfaction of Cervical Ripening With Transcervical Use of the Foley Catheter in an Outpatient Setting Unknown status NCT01605474
4 Switching to Powder Free Latex Gloves in the Entire OR as Part of a New ' Latex Safe' Protocol: a Safe Alternative? A Prospective, Observational Cohort Study Completed NCT02575053
5 Obstructive Sleep Apnea Among Pregnant Women With Chronic Hypertension Completed NCT03230110
6 The Effect of Pelvic Floor Muscle Training on the Quality of Life and Functionality in Women With Urinary Incontinence: a Randomized Controlled Trial Completed NCT03514147
7 The Comparison Of The Efficacy Of Three Methods Applied During Venous Blood Sampling On Reducing Pain And Fear In Children Completed NCT03720808
8 TranQuill™ Sling Snoreplasty for Snoring and Mild Obstructive Sleep Apnea: A Single-arm, Pilot Study for Safety and Effectiveness Completed NCT02364518
9 Comparison of Pre-Induction Cervical Ripening Using Prepidil Gel Administered Through a Urinary Balloon Catheter. Completed NCT01390233 Prepidil Gel
10 Effectiveness of Pelvic Floor Muscles Training in Group for Women With Urinary Incontinence: a Randomized Clinical Test Active, not recruiting NCT03500185
11 Prevalence of High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing. Reversibility After Treatment (The Kids TRIAL STUDY). Not yet recruiting NCT03696654
12 Yulex Glove Prospective Study Terminated NCT01133288

Search NIH Clinical Center for Latex Allergy

Genetic Tests for Latex Allergy

Anatomical Context for Latex Allergy

MalaCards organs/tissues related to Latex Allergy:

40
Testes, Skin, Lung, Spinal Cord, T Cells, B Cells, Eye

Publications for Latex Allergy

Articles related to Latex Allergy:

(show top 50) (show all 1435)
# Title Authors PMID Year
1
ENEA, a peach and apricot IgE-binding protein cross-reacting with the latex major allergen Hev b 5. 42
31254775 2019
2
Protecting Patients with Latex Allergies. 42
30589712 2019
3
Component-resolved diagnosis from latex allergy by microarray. 54 61
20210809 2010
4
Interference of cross-reactive carbohydrates in the determination of specific IgE in alcohol drinkers and strategies to minimize it: the example of latex. 54 61
18939728 2008
5
Latex allergy: low prevalence of immunoglobulin E to highly purified proteins Hev b 2 and Hev b 13. 54 61
17850383 2007
6
Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. 54 61
15731584 2005
7
Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum. 54 61
15725197 2005
8
Prevalence of evaluation for latex allergy and association with practice characteristics in United States dermatologists: results of a cross-sectional survey. 54 61
11526518 2001
9
Assessment of IgE allergen specificity among latex-allergic health care workers: review of IgE-binding components of various latex extracts. 54 61
11152171 2000
10
Latex allergy in the workplace. 54 61
11053535 2000
11
[A case of latex allergy with bronchial asthma]. 54 61
11193320 2000
12
Latex allergy in children on home mechanical ventilation. 54 61
11035669 2000
13
Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy. 54 61
11275264 2000
14
Prevention of latex allergy by selection of low-allergen gloves. 54 61
10718848 2000
15
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy. 54 61
9802376 1998
16
Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy. 54 61
9756201 1998
17
[Latex allergy in health services workers]. 54 61
9825659 1998
18
IgE from latex-allergic patients binds to cloned and expressed B cell epitopes of prohevein. 54 61
9548517 1997
19
Natural rubber latex allergy in children who had not undergone surgery and children who had undergone multiple operations. 54 61
9389289 1997
20
Natural latex, grass pollen, and weed pollen share IgE epitopes. 54 61
9314348 1997
21
Prevalence of latex-specific IgE antibodies in atopic and nonatopic children with type I diabetes. 54 61
9096963 1997
22
A nurse with anaphylaxis to stone fruits and latex sensitivity: potential diagnostic difficulties to consider. 54 61
8970444 1996
23
Latex allergy: allergen identification in Hevea braziliensis fractions by immunoblotting. 54 61
8911704 1996
24
Comparison of latex-specific IgE binding among nonammoniated latex, ammoniated latex, and latex glove allergenic extracts by ELISA and immunoblot inhibition. 54 61
8626990 1996
25
A two-dimensional electrophoretic analysis of latex peptides reacting with IgE and IgG antibodies from patients with latex allergy. 54 61
8527952 1996
26
Cross-reacting allergens in natural rubber latex and avocado. 54 61
7636053 1995
27
Banana allergy in patients with immediate-type hypersensitivity to natural rubber latex: characterization of cross-reacting antibodies and allergens. 54 61
8006321 1994
28
Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex proteins in patients with spina bifida and histories of anaphylaxis. 54 61
8195677 1994
29
Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources. 54 61
8145008 1994
30
Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. 54 61
8509575 1993
31
Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy. 54 61
1587468 1992
32
Current state of occupational latex allergy. 61
31850921 2019
33
Myelomeningocele: Medical Considerations and Stomatologic Aspects in the Dental Treatment. 61
31567772 2019
34
Allergen-specific IgE to recombinant latex allergens in occupational allergy diagnostics. 61
31090202 2019
35
Allergy topics for dental practitioners. 61
31355763 2019
36
Effect of intravaginal vibratory versus electric stimulation on the pelvic floor muscles: A randomized clinical trial. 61
31403114 2019
37
Anaphylaxis triggered by prick test with latex extract: a case report. 61
29898012 2019
38
Safety of a powder-free latex allergy protocol in the operating theatre: A prospective, observational cohort study. 61
30817368 2019
39
Anorectal physiology in health: A randomized trial to determine the optimum catheter for the balloon expulsion test. 61
30703851 2019
40
Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing-Design and rationale. 61
30393915 2019
41
Profile Shift in Latex Sensitization over the Last 20 Years. 61
30212836 2019
42
Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies. 61
30976286 2019
43
Latex Allergy Risks Live On. 61
30249547 2018
44
Spontaneous disappearance of severe latex allergy in an adult. 61
30618228 2018
45
Knowledge and Awareness towards Occupational Hazards and Preventive Measures among Students and Dentists in Jazan Dental College, Saudi Arabia. 61
30337998 2018
46
Latex hypersensitivity to injection devices for biologic therapies in psoriasis patients. 61
30235360 2018
47
Latex Allergy and Occupational Exposure: The Patient's Perspective. 61
30073963 2018
48
Latex sensitization in patients with myelomeningocele: contribution of microarray technique. 61
29479928 2018
49
Safety of a condom uterine balloon tamponade (ESM-UBT) device for uncontrolled primary postpartum hemorrhage among facilities in Kenya and Sierra Leone. 61
29764416 2018
50
[Latex sensitization and allergy in Hospital General de Mexico surgery residents]. 61
29983010 2018

Variations for Latex Allergy

Expression for Latex Allergy

Search GEO for disease gene expression data for Latex Allergy.

Pathways for Latex Allergy

Pathways related to Latex Allergy according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF RNASE3 IL5 IL4 IL18 IL13
2
Show member pathways
13.76 TNF IL5 IL4 IL18 IL13 CCL4
3
Show member pathways
13.64 TNF IL5 IL4 IL18 IL13 IFNG
4
Show member pathways
13.51 TNF IL5 IL4 IL18 IL13 IFNG
5
Show member pathways
13.38 TNF IL5 IL4 IL18 IL13 CCL4
6
Show member pathways
13.26 TNF IL5 IL4 IL18 IL13 CCL4
7
Show member pathways
13.25 TNF IL5 IL4 IL18 IL13 IGHE
8
Show member pathways
12.84 TNF RNASE3 IL5 IL4 IL13 IFNG
9
Show member pathways
12.62 TNF IL4 IL18 IGHE IFNG HLA-DQB1
10
Show member pathways
12.59 TNF IL5 IL4 IL13 IGHE
11
Show member pathways
12.56 TNF IL5 IL4 IL18 IL13 IFNG
12
Show member pathways
12.54 TNF IL5 IL4 IFNG
13
Show member pathways
12.34 IL5 IL4 IL13 IFNG
14
Show member pathways
12.34 TNF IL18 CCL4 CCL3 CCL20
15
Show member pathways
12.32 TNF IL5 IL4 IL13 IFNG CCL20
16
Show member pathways
12.26 TNF IL4 IFNG HLA-DQB1
17
Show member pathways
12.26 TNF IL5 IL4 IL18 IL13 IFNG
18 12.23 TNF IL18 IFNG HLA-DQB1
19
Show member pathways
12.18 TNF IL4 IFNG CCL20
20
Show member pathways
12.05 TNF IL4 IL13 IFNG
21 12 TNF IL5 IL4 IFNG
22 12 TNF IL4 IL18 IL13 IGHE
23
Show member pathways
11.99 TNF IL18 IFNG
24
Show member pathways
11.99 IL4 IL18 IFNG CCL4 CCL3
25 11.95 TNF IL4 IFNG
26 11.92 TNF IL5 IL4 HLA-DQB1
27 11.88 TNF IL18 IFNG HLA-DQB1 CCL3 CCL20
28 11.84 IL5 IL4 IL13 IFNG
29 11.82 IL18 IFNG CCL4 CCL3
30
Show member pathways
11.78 TNF IL5 IL4 IFNG
31 11.66 IL5 IL4 IGHE
32 11.6 TNF IL5 IL4 IL13 CCL4 CCL3
33 11.6 TNF IL5 IL4 IL18 IL13 IFNG
34 11.55 TNF IL18 IFNG
35 11.53 TNF IL18 IFNG
36 11.53 IL5 IL4 IL13 IFNG
37 11.41 TNF IL18 IFNG
38 11.35 IL5 IL4 IFNG
39 11.27 IL18 IL13 IFNG
40 11.24 TNF IL5 IL4 IL18 IL13 IFNG
41 11.23 TNF IL5 IL4 IL13 IFNG
42 11.21 IL5 IL4 IL13 IFNG
43 11.19 TNF IL4 IL18 IL13 CCL4 CCL3
44 11.08 TNF IL4 IL18 IL13 IFNG CCL4
45 11 IL18 IFNG
46 10.96 TNF IL5 IL4 IL18 IL13 CCL4
47 10.89 TNF CCL3

GO Terms for Latex Allergy

Cellular components related to Latex Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF RNASE3 IL5 IL4 IL18 IL13
2 extracellular region GO:0005576 9.4 TNF RNASE3 IL5 IL4 IL18 IL13

Biological processes related to Latex Allergy according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.92 TNF IL5 IL18 CCL3
2 cell-cell signaling GO:0007267 9.91 IL18 CCL4 CCL3 CCL20
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.9 TNF CCL4 CCL3 CCL20
4 response to virus GO:0009615 9.85 TNF IFNG CCL4
5 cellular response to interferon-gamma GO:0071346 9.85 CCL4 CCL3 CCL20
6 positive regulation of cold-induced thermogenesis GO:0120162 9.84 IL4 IL18 IL13
7 positive regulation of inflammatory response GO:0050729 9.82 TNF IL18 CCL3
8 neutrophil chemotaxis GO:0030593 9.82 CCL4 CCL3 CCL20
9 cellular response to interleukin-1 GO:0071347 9.81 CCL4 CCL3 CCL20
10 positive regulation of gene expression GO:0010628 9.8 TNF IL4 IL18 IL13 IFNG CCL3
11 inflammatory response GO:0006954 9.8 TNF IL5 IL18 IL13 CCL4 CCL3
12 chemokine-mediated signaling pathway GO:0070098 9.79 CCL4 CCL3 CCL20
13 cellular response to organic cyclic compound GO:0071407 9.79 TNF IL18 CCL3
14 defense response to bacterium GO:0042742 9.77 TNF RNASE3 IGHE EPPIN CCL20
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.76 TNF IL18 IL13
16 monocyte chemotaxis GO:0002548 9.72 CCL4 CCL3 CCL20
17 positive regulation of B cell proliferation GO:0030890 9.71 IL5 IL4 IL13
18 positive regulation of amyloid-beta formation GO:1902004 9.68 TNF IFNG
19 positive regulation of calcium-mediated signaling GO:0050850 9.68 CCL4 CCL3
20 astrocyte activation GO:0048143 9.68 TNF IFNG
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 TNF IFNG
22 lymphocyte chemotaxis GO:0048247 9.67 CCL4 CCL3 CCL20
23 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL18
24 positive regulation of podosome assembly GO:0071803 9.66 TNF IL5
25 negative regulation by host of viral transcription GO:0043922 9.65 CCL4 CCL3
26 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IFNG
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF IL18 CCL3
28 negative regulation of amyloid-beta clearance GO:1900222 9.63 TNF IFNG
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL4 IFNG
30 microglial cell activation GO:0001774 9.63 TNF IL13 IFNG
31 cytokine-mediated signaling pathway GO:0019221 9.61 TNF IL5 IL4 IL18 IL13 IGHE
32 positive regulation of natural killer cell chemotaxis GO:2000503 9.59 CCL4 CCL3
33 neuroinflammatory response GO:0150076 9.58 IL4 IFNG
34 type 2 immune response GO:0042092 9.57 IL4 IL18
35 positive regulation of cellular respiration GO:1901857 9.56 IL4 IFNG
36 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 TNF IL4 IL18 IL13 IFNG
37 negative regulation of complement-dependent cytotoxicity GO:1903660 9.52 IL4 IL13
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IFNG
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 TNF IFNG
40 positive regulation of nitrogen compound metabolic process GO:0051173 9.4 TNF IFNG
41 immune response GO:0006955 9.36 TNF IL5 IL4 IL18 IL13 IGHE

Molecular functions related to Latex Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL4 CCL3 CCL20
2 CCR5 chemokine receptor binding GO:0031730 9.32 CCL4 CCL3
3 cytokine activity GO:0005125 9.28 TNF IL5 IL4 IL18 IL13 IFNG
4 CCR1 chemokine receptor binding GO:0031726 9.26 CCL4 CCL3
5 CCR chemokine receptor binding GO:0048020 9.13 CCL4 CCL3 CCL20

Sources for Latex Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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