Latex Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Latex Allergy

MalaCards integrated aliases for Latex Allergy:

Name: Latex Allergy ¹¹ ⁵³ ⁴¹ ¹⁴ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060532

UMLS ⁷¹ C0577628

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Summaries for Latex Allergy

MedlinePlus: ⁴¹ Latex is a milky fluid that comes from the tropical rubber tree. Hundreds of everyday products contain latex. Repeated exposure to a protein in natural latex can make you more likely to develop a latex allergy. If your immune system detects the protein, a reaction can start in minutes. You could get a rash or asthma. In rare cases you could have a severe reaction called anaphylaxis. Your doctor may use a physical exam and skin and blood tests to diagnose it. There are medicines to treat a reaction, but it is best to try to avoid latex. Common latex products include: Gloves Condoms Balloons Rubber bands Shoe soles Pacifiers You can find latex-free versions of these products.

MalaCards based summary: Latex Allergy is related to ige responsiveness, atopic and dermatitis, and has symptoms including exanthema An important gene associated with Latex Allergy is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Development and heterogeneity of the ILC family and IL12 signaling mediated by STAT4. Affiliated tissues include skin, spinal cord and bone marrow, and related phenotype is digestive/alimentary.

Disease Ontology: ¹¹ An allergic disease that is triggered by latex.

Wikipedia: ⁷⁵ Latex allergy is a medical term encompassing a range of allergic reactions to the proteins present in... more...

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Related Diseases for Latex Allergy

Diseases related to Latex Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)

#	Related Disease	Score	Top Affiliating Genes
1	ige responsiveness, atopic	31.4	IL13 IGHE
2	dermatitis	31.1	IL18 IL13 IGHE
3	contact dermatitis	31.1	PEDS1 IL18 IL13
4	urticaria	30.9	IL18 IL13 IGHE ENPP3 CD63
5	allergic rhinitis	30.8	IL18 IL13 IGHE
6	chronic rhinitis	30.7	PEDS1 PDCL IL13 GHITM
7	occupational asthma	30.6	PEDS1 IL13 GHITM
8	allergic asthma	30.3	IL18 IL13 IGHE
9	dermatitis, atopic	30.3	PEDS1 IL18 IL13 IGHE GHITM
10	status asthmaticus	30.0	PDCL IL13
11	food allergy	30.0	SCP2 PEDS1 PDCL IL13 IGHE ENPP3
12	dermatographia	30.0	IGHE ENPP3 CD63
13	allergic conjunctivitis	30.0	IL13 IGHE
14	penicillin allergy	30.0	IL13 IGHE ENPP3
15	oxirane allergy	29.7	PEDS1 ENPP3 CD63
16	drug allergy	29.6	PEDS1 IL13 IGHE ENPP3 CD63
17	vegetable allergy	29.1	SCP2 PEDS1 PDCL GHITM
18	fruit allergy	28.9	SCP2 PEDS1 PDCL IL13 GHITM ENPP3
19	pollen allergy	28.0	SCP2 PEDS1 PDCL IL13 GHITM ENPP3
20	neural tube defects	10.9
21	meningocele	10.9
22	allergic disease	10.7
23	rhinitis	10.7
24	angioedema	10.6
25	conjunctivitis	10.6
26	exanthem	10.5
27	allergic contact dermatitis	10.5
28	myelomeningocele	10.5
29	asthma	10.4
30	myelodysplastic syndrome	10.3
31	mercury poisoning	10.3	IL18 IL13
32	dermatitis, atopic, 2	10.2
33	irritant dermatitis	10.2
34	toxocariasis	10.2	IL13 IGHE
35	eczema herpeticum	10.2	IL13 IGHE
36	paragonimiasis	10.2	IL13 IGHE
37	urinary schistosomiasis	10.2	IL13 IGHE
38	timothy grass allergy	10.2	PEDS1 PDCL
39	cow milk allergy	10.2	PEDS1 IL13
40	exercise-induced bronchoconstriction	10.2	IL13 IGHE
41	eosinophilic gastroenteritis	10.2	IL13 IGHE
42	immunoglobulin e concentration, serum	10.2
43	bladder exstrophy-epispadias-cloacal exstrophy complex	10.2
44	bladder exstrophy	10.2
45	skin disease	10.2
46	hypereosinophilic syndrome	10.2
47	fish allergy	10.2	PEDS1 PDCL
48	strongyloidiasis	10.2	IL13 IGHE
49	chronic conjunctivitis	10.2	IL13 IGHE
50	cysticercosis	10.2	IL18 IGHE

Graphical network of the top 20 diseases related to Latex Allergy:

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Symptoms & Phenotypes for Latex Allergy

UMLS symptoms related to Latex Allergy:

exanthema

MGI Mouse Phenotypes related to Latex Allergy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.1	CD63 ENPP3 EPPIN IL13 IL18 ODF2

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Drugs & Therapeutics for Latex Allergy

Interventional clinical trials:

#	Name	Status	NCT ID
1	Switching to Powder Free Latex Gloves in the Entire OR as Part of a New ' Latex Safe' Protocol: a Safe Alternative? A Prospective, Observational Cohort Study	Completed	NCT02575053
2	The COVID-19 Pandemic Process Increase Latex Glove Use and Latex Allergy Complaints in Hospital Nurses? Survey Study	Completed	NCT05515276
3	Yulex Glove Prospective Study	Terminated	NCT01133288

Search NIH Clinical Center for Latex Allergy

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Genetic Tests for Latex Allergy

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Anatomical Context for Latex Allergy

Organs/tissues related to Latex Allergy:

MalaCards : Skin, Spinal Cord, Bone Marrow, B Cells, Lung, Heart, Eye

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Publications for Latex Allergy

Articles related to Latex Allergy:

(show top 50) (show all 1474)

#	Title	Authors	PMID	Year
1	Secondary prevention of latex allergy. ⁶² ⁴¹	Nettis E...Miniello A	35852898	2022
2	Clinical and quality of life assessment in patients with latex allergy during COVID-19 pandemic: Possible protective role of continuous latex immunotherapy. ⁶² ⁴¹	Di Rienzo A...Nucera E	35575237	2022
3	CoronaVac/Sinovac COVID-19 Vaccine-Related Hypersensitivity Reactions and Second-Dose Vaccine Administration: Tertiary Allergy Center Experience. ⁶² ⁴¹	Gumusburun R...Sin AZ	35462361	2022
4	Component-resolved diagnosis from latex allergy by microarray. ⁵³ ⁶²	Ebo DG...Stevens WJ	20210809	2010
5	Interference of cross-reactive carbohydrates in the determination of specific IgE in alcohol drinkers and strategies to minimize it: the example of latex. ⁵³ ⁶²	Coutinho V...Gonzalez-Quintela A	18939728	2008
6	Latex allergy: low prevalence of immunoglobulin E to highly purified proteins Hev b 2 and Hev b 13. ⁵³ ⁶²	Palosuo T...Turjanmaa K	17850383	2007
7	Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. ⁵³ ⁶²	Brown RH...Kleeberger SR	15731584	2005
8	Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum. ⁵³ ⁶²	Fujimura T...Ono K	15725197	2005
9	Prevalence of evaluation for latex allergy and association with practice characteristics in United States dermatologists: results of a cross-sectional survey. ⁵³ ⁶²	Warshaw EM...Nelson D	11526518	2001
10	Assessment of IgE allergen specificity among latex-allergic health care workers: review of IgE-binding components of various latex extracts. ⁵³ ⁶²	Nielsen PS...Nolte H	11152171	2000
11	[A case of latex allergy with bronchial asthma]. ⁵³ ⁶²	Ise S...Hara N	11193320	2000
12	Latex allergy in the workplace. ⁵³ ⁶²	Toraason M...Germolec D	11053535	2000
13	Latex allergy in children on home mechanical ventilation. ⁵³ ⁶²	Nakamura CT...Davidson Ward SL	11035669	2000
14	Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy. ⁵³ ⁶²	Banerjee B...Kurup VP	11275264	2000
15	Prevention of latex allergy by selection of low-allergen gloves. ⁵³ ⁶²	Mahler V...Valenta R	10718848	2000
16	IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy. ⁵³ ⁶²	Ylitalo L...Reunala T	9802376	1998
17	Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy. ⁵³ ⁶²	Blanco C...Castillo R	9756201	1998
18	[Latex allergy in health services workers]. ⁵³ ⁶²	Obtulowicz K...Mazurkiewicz A	9825659	1998
19	IgE from latex-allergic patients binds to cloned and expressed B cell epitopes of prohevein. ⁵³ ⁶²	Banerjee B...Kurup VP	9548517	1997
20	Natural rubber latex allergy in children who had not undergone surgery and children who had undergone multiple operations. ⁵³ ⁶²	Ylitalo L...Reunala T	9389289	1997
21	Natural latex, grass pollen, and weed pollen share IgE epitopes. ⁵³ ⁶²	Fuchs T...Valenta R	9314348	1997
22	Prevalence of latex-specific IgE antibodies in atopic and nonatopic children with type I diabetes. ⁵³ ⁶²	Danne T...Wahn U	9096963	1997
23	A nurse with anaphylaxis to stone fruits and latex sensitivity: potential diagnostic difficulties to consider. ⁵³ ⁶²	Weiss SJ...Halsey JF	8970444	1996
24	Latex allergy: allergen identification in Hevea braziliensis fractions by immunoblotting. ⁵³ ⁶²	Muguerza J...Vervloet D	8911704	1996
25	Comparison of latex-specific IgE binding among nonammoniated latex, ammoniated latex, and latex glove allergenic extracts by ELISA and immunoblot inhibition. ⁵³ ⁶²	Akasawa A...Lin Y	8626990	1996
26	A two-dimensional electrophoretic analysis of latex peptides reacting with IgE and IgG antibodies from patients with latex allergy. ⁵³ ⁶²	Kurup VP...Fink JN	8527952	1996
27	Cross-reacting allergens in natural rubber latex and avocado. ⁵³ ⁶²	Ahlroth M...Palosuo T	7636053	1995
28	Banana allergy in patients with immediate-type hypersensitivity to natural rubber latex: characterization of cross-reacting antibodies and allergens. ⁵³ ⁶²	Makinen-Kiljunen S	8006321	1994
29	Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex proteins in patients with spina bifida and histories of anaphylaxis. ⁵³ ⁶²	Alenius H...Fink J	8195677	1994
30	Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources. ⁵³ ⁶²	Hamilton RG...Yunginger JW	8145008	1994
31	Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. ⁵³ ⁶²	Kurup VP...Fink JN	8509575	1993
32	Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy. ⁵³ ⁶²	Alenius H...Palosuo T	1587468	1992
33	Contact Urticaria Syndrome: a Comprehensive Review. ⁶²	Gimenez-Arnau AM...Maibach HI	36415744	2022
34	Sequence of mixed ophthalmic operating lists: A national survey of UK consultants. ⁶²	Kishikova L...Liu C	34197240	2022
35	Management of internal and external root resorption in primary teeth of a 3-year-old with myelomeningocele: A case report. ⁶²	Talekar AL...Chunawala YK	35201631	2022
36	Latex Allergy Alerts in the Age of CPOE: Assessing the Risk From Injectable Medications. ⁶²	Preheim EA...Weant KA	35898253	2022
37	Latex Allergy as an Independent Risk Factor for Prosthetic Joint Infection. ⁶²	Sherman WF...Lee OC	35394382	2022
38	Prevalence and Patterns of Latex Glove Allergy among Healthcare Workers in a Tertiary Care Center In South India - A Cross-Sectional Study. ⁶²	Sakkaravarthi V...Rajappa M	36262582	2022
39	Lin's Self-Retaining Abdominal Ultrasound Probe Method for Hands-Free Ultrasound-Guided Hysteroscopic Procedures: A Single-Operator Study. ⁶²	Lin BL...Azhary JMK	36158297	2022
40	Latex Anaphylaxis Caused by Occupational Exposure to Balloons. ⁶²	West RW...Sharip A	35836451	2022
41	Adverse Event Leads to Quality Improvement Plan: Learning From a Classroom Latex Exposure. ⁶²	Posanka B	35148646	2022
42	Tomato Allergy: The Characterization of the Selected Allergens and Antioxidants of Tomato (Solanum lycopersicum)-A Review. ⁶²	Wlodarczyk K...Majak I	35453329	2022
43	[Latex allergy: therapeutic options]. ⁶²	Jimenez-Carrillo CE...Garcia-Aguirre A	34998311	2022
44	[Latex allergy: a review on the most important aspects]. ⁶²	Gonzalez-Diaz SN...Acuna-Ortega Acuna-Ortega N	34998308	2022
45	Concomitant chronic spontaneous urticaria treatment might hinder the diagnosis of occupational latex-induced anaphylaxis: A case report. ⁶²	Lertvipapath P...Sompornrattanaphan M	34953476	2021
46	Study of Latex Glove Associated Dermatoses Among Nurses in a Tertiary Care Hospital. ⁶²	Tomy C...Madhukara J	34934719	2021
47	Fatal anaphylaxis due to peanut exposure from oral intercourse. ⁶²	McKibbin LR...Jeimy S	34663441	2021
48	Efficacy of omalizumab in reducing latex allergy. ⁶²	Aruanno A...Nucera E	34849147	2021
49	Pediatric Allergy: An Overview. ⁶²	Rajaee A...Pohlgeers KM	34311855	2021
50	Update on latex allergy: New insights into an old problem. ⁶²	Parisi CAS...Yanez A	34386153	2021

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Genes for Latex Allergy

Genes related to Latex Allergy (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	18.51	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8195677 9802376 11275264 (more) 1587468 8527952 8006321 9314348 8145008 8509575 10718848 8911704 11053535 15725197 11526518 11152171 9096963 8970444 9825659 9756201 9548517 7636053 17850383 20210809 11193320 15982232 9389289 8626990 18939728 11035669
2	IL13	Interleukin 13	Protein Coding	16.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15731584
3	IL18	Interleukin 18	Protein Coding	11.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	9.05	DISEASES inferred ¹⁴ ¹⁴
5	PDCL	Phosducin Like	Protein Coding	6.33	DISEASES inferred ¹⁴
6	PEDS1	Plasmanylethanolamine Desaturase 1	Protein Coding	6.28	DISEASES inferred ¹⁴
7	ODF2	Outer Dense Fiber Of Sperm Tails 2	Protein Coding	6.1	DISEASES inferred ¹⁴
8	NDUFB4	NADH:Ubiquinone Oxidoreductase Subunit B4	Protein Coding	5.96	DISEASES inferred ¹⁴
9	ENPP3	Ectonucleotide Pyrophosphatase/Phosphodiesterase 3	Protein Coding	5.9	DISEASES inferred ¹⁴
10	NRL	Neural Retina Leucine Zipper	Protein Coding	5.86	DISEASES inferred ¹⁴
11	COPS7A	COP9 Signalosome Subunit 7A	Protein Coding	5.83	DISEASES inferred ¹⁴
12	GHITM	Growth Hormone Inducible Transmembrane Protein	Protein Coding	5.82	DISEASES inferred ¹⁴
13	SCP2	Sterol Carrier Protein 2	Protein Coding	5.66	DISEASES inferred ¹⁴
14	CD63	CD63 Molecule	Protein Coding	5.56	DISEASES inferred ¹⁴

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Variations for Latex Allergy

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Expression for Latex Allergy

Search GEO for disease gene expression data for Latex Allergy.

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Pathways for Latex Allergy

Pathways related to Latex Allergy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Development and heterogeneity of the ILC family ⁷⁴	10.46	IL18 IL13
2	IL12 signaling mediated by STAT4 ⁶¹	10.05	IL18 IL13

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GO Terms for Latex Allergy

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Sources for Latex Allergy

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LTX001 MIFTS: 31	Latex Allergy Categories: Immune diseases	Data Licensing For inquiries, contact: [email protected]
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