MCID: LTT008
MIFTS: 21

Lattice Corneal Dystrophy Type Ii

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lattice Corneal Dystrophy Type Ii

MalaCards integrated aliases for Lattice Corneal Dystrophy Type Ii:

Name: Lattice Corneal Dystrophy Type Ii 25 72
Meretoja Syndrome 25 29 6 72
Amyloid Cranial Neuropathy with Lattice Corneal Dystrophy 25
Lattice Corneal Dystrophy, Gelsolin Type 25
Familial Amyloid Polyneuropathy Type Iv 25
Amyloidosis Due to Mutant Gelsolin 25
Familial Amyloidosis, Finnish Type 25
Gelsolin-Related Amyloidosis 25
Amyloidosis, Meretoja Type 25
Amyloidosis, Finnish Type 25
Kymenlaakso Syndrome 25
Amyloidosis V 25

Classifications:



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UMLS 72 C1622345 C1628319

Summaries for Lattice Corneal Dystrophy Type Ii

Genetics Home Reference : 25 Lattice corneal dystrophy type II is characterized by an accumulation of protein clumps called amyloid deposits in tissues throughout the body. The deposits frequently occur in blood vessel walls and basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Amyloid deposits lead to characteristic signs and symptoms involving the eyes, nerves, and skin that worsen with age. The earliest sign of this condition, which is usually identified in a person's twenties, is accumulation of amyloid deposits in the cornea (lattice corneal dystrophy). The cornea is the clear, outer covering of the eye. It is made up of several layers of tissue, and in lattice corneal dystrophy type II, the amyloid deposits form in the stromal layer. The amyloid deposits form as delicate, branching fibers that create a lattice pattern. Because these protein deposits cloud the cornea, they often lead to vision impairment. In addition, affected individuals can have recurrent corneal erosions, which are caused by separation of particular layers of the cornea from one another. Corneal erosions are very painful and can cause sensitivity to bright light (photophobia). Amyloid deposits and corneal erosions are usually bilateral, which means they affect both eyes. As lattice corneal dystrophy type II progresses, the nerves become involved, typically starting in a person's forties. It is thought that the amyloid deposits disrupt nerve function. Dysfunction of the nerves in the head and face (cranial nerves) can cause paralysis of facial muscles (facial palsy); decreased sensations in the face (facial hypoesthesia); and difficulty speaking, chewing, and swallowing. Dysfunction of the nerves that connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, and heat (peripheral nerves) can cause loss of sensation and weakness in the limbs (peripheral neuropathy). Peripheral neuropathy usually occurs in the lower legs and arms, leading to muscle weakness, clumsiness, and difficulty sensing vibrations. The skin is also commonly affected in people with lattice corneal dystrophy type II, typically beginning in a person's forties. People with this condition may have thickened, sagging skin, especially on the scalp and forehead, and a condition called cutis laxa, which is characterized by loose skin that lacks elasticity. The skin can also be dry and itchy. Because of loose skin and muscle paralysis in the face, individuals with lattice corneal dystrophy type II can have a facial expression that appears sad.

MalaCards based summary : Lattice Corneal Dystrophy Type Ii, also known as meretoja syndrome, is related to amyloidosis, finnish type and familial amyloidosis, finnish type. An important gene associated with Lattice Corneal Dystrophy Type Ii is GSN (Gelsolin). Affiliated tissues include brain, skin and eye.

Related Diseases for Lattice Corneal Dystrophy Type Ii

Diseases in the Lattice Corneal Dystrophy family:

Corneal Dystrophy, Lattice Type I Corneal Dystrophy, Lattice Type Iiia
Lattice Corneal Dystrophy Type Ii

Diseases related to Lattice Corneal Dystrophy Type Ii via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 amyloidosis, finnish type 12.4
2 familial amyloidosis, finnish type 12.0
3 corneal dystrophy 10.5
4 lattice corneal dystrophy 10.5
5 amyloidosis 10.5
6 polyneuropathy 10.4
7 hereditary amyloidosis 10.3
8 recurrent corneal erosion 10.3
9 keratitis, hereditary 10.3
10 facial paralysis 10.3
11 corneal dystrophy, gelatinous drop-like 10.2
12 cataract 10.2
13 pure autonomic failure 10.2
14 open-angle glaucoma 10.1
15 macroglossia 10.1
16 neurilemmoma 10.1
17 hypersomnia 10.1
18 peripheral nervous system disease 10.0
19 fainting 10.0
20 amyloidosis, hereditary, transthyretin-related 9.9
21 carpal tunnel syndrome 9.9
22 seizures, benign familial neonatal, 1 9.9
23 helix syndrome 9.9
24 anhidrosis 9.9
25 autonomic neuropathy 9.9
26 nephrotic syndrome 9.9
27 cutis laxa 9.9
28 blepharochalasis 9.9
29 kidney disease 9.9
30 end stage renal failure 9.9
31 neuropathy 9.9
32 lichen amyloidosis 9.9
33 eye disease 9.8

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy Type Ii:



Diseases related to Lattice Corneal Dystrophy Type Ii

Symptoms & Phenotypes for Lattice Corneal Dystrophy Type Ii

Drugs & Therapeutics for Lattice Corneal Dystrophy Type Ii

Search Clinical Trials , NIH Clinical Center for Lattice Corneal Dystrophy Type Ii

Genetic Tests for Lattice Corneal Dystrophy Type Ii

Genetic tests related to Lattice Corneal Dystrophy Type Ii:

# Genetic test Affiliating Genes
1 Meretoja Syndrome 29 GSN

Anatomical Context for Lattice Corneal Dystrophy Type Ii

MalaCards organs/tissues related to Lattice Corneal Dystrophy Type Ii:

41
Brain, Skin, Eye, Spinal Cord

Publications for Lattice Corneal Dystrophy Type Ii

Articles related to Lattice Corneal Dystrophy Type Ii:

(show all 16)
# Title Authors PMID Year
1
Meretoja Syndrome: General Considerations and Contributions of Plastic Surgery in Surgical Treatment. 38
29149274 2017
2
The First Argentinian Family with Familial Amyloidosis of the Finnish Type. 38
28924445 2017
3
[Meretoja syndrome: Identification of a family and description of the corneal involvement by confocal microscopy]. 38
25913657 2015
4
[The revised newest IC³D classification of corneal dystrophies]. 38
25803558 2015
5
Corneal melt in lattice corneal dystrophy type II after cataract surgery. 38
19101443 2009
6
Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family. 38
17534828 2007
7
[Corneal dystrophies in the light of modern molecular genetic research]. 38
12125408 2002
8
Confocal microscopy in Meretoja syndrome. 38
11973384 2002
9
Corneal morphology and sensitivity in lattice dystrophy type II (familial amyloidosis, Finnish type). 38
11222521 2001
10
Late onset lattice corneal dystrophy with systemic familial amyloidosis, amyloidosis V, in an English family. 38
10729296 2000
11
Lattice corneal dystrophy type II associated with familial amyloid polyneuropathy type IV. 38
8684801 1996
12
[Lattice corneal dystrophy type II with familial amyloid polyneuropathy type IV]. 38
8285156 1993
13
Lattice corneal dystrophy type II with familial amyloid polyneuropathy type IV. 38
8145387 1993
14
Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II. 38
1658654 1991
15
Clinical and histopathologic studies of two families with lattice corneal dystrophy and familial systemic amyloidosis (Meretoja syndrome). 38
1923356 1991
16
Meretoja syndrome. Lattice dystrophy of the cornea with hereditary generalized amyloidosis. 38
314081 1979

Variations for Lattice Corneal Dystrophy Type Ii

Expression for Lattice Corneal Dystrophy Type Ii

Search GEO for disease gene expression data for Lattice Corneal Dystrophy Type Ii.

Pathways for Lattice Corneal Dystrophy Type Ii

GO Terms for Lattice Corneal Dystrophy Type Ii

Sources for Lattice Corneal Dystrophy Type Ii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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