MCID: LTT008
MIFTS: 23

Lattice Corneal Dystrophy Type Ii

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lattice Corneal Dystrophy Type Ii

MalaCards integrated aliases for Lattice Corneal Dystrophy Type Ii:

Name: Lattice Corneal Dystrophy Type Ii 26 74
Meretoja Syndrome 26 30 6 74
Amyloid Cranial Neuropathy with Lattice Corneal Dystrophy 26
Lattice Corneal Dystrophy, Gelsolin Type 26
Familial Amyloid Polyneuropathy Type Iv 26
Amyloidosis Due to Mutant Gelsolin 26
Familial Amyloidosis, Finnish Type 26
Gelsolin-Related Amyloidosis 26
Amyloidosis, Meretoja Type 26
Amyloidosis, Finnish Type 26
Kymenlaakso Syndrome 26
Amyloidosis V 26

Classifications:



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Summaries for Lattice Corneal Dystrophy Type Ii

Genetics Home Reference : 26 Lattice corneal dystrophy type II is characterized by an accumulation of protein clumps called amyloid deposits in tissues throughout the body. The deposits frequently occur in blood vessel walls and basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Amyloid deposits lead to characteristic signs and symptoms involving the eyes, nerves, and skin that worsen with age.

MalaCards based summary : Lattice Corneal Dystrophy Type Ii, also known as meretoja syndrome, is related to amyloidosis, finnish type and familial amyloidosis, finnish type. An important gene associated with Lattice Corneal Dystrophy Type Ii is GSN (Gelsolin). The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include eye, skin and liver.

Related Diseases for Lattice Corneal Dystrophy Type Ii

Diseases in the Lattice Corneal Dystrophy family:

Corneal Dystrophy, Lattice Type I Corneal Dystrophy, Lattice Type Iiia
Lattice Corneal Dystrophy Type Ii

Diseases related to Lattice Corneal Dystrophy Type Ii via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 amyloidosis, finnish type 12.3
2 familial amyloidosis, finnish type 11.9
3 corneal dystrophy 10.5
4 lattice corneal dystrophy 10.5
5 polyneuropathy 10.3
6 cataract 10.2
7 amyloidosis 10.2
8 hereditary amyloidosis 10.1
9 anhidrosis 9.9
10 neuropathy 9.9

Graphical network of the top 20 diseases related to Lattice Corneal Dystrophy Type Ii:



Diseases related to Lattice Corneal Dystrophy Type Ii

Symptoms & Phenotypes for Lattice Corneal Dystrophy Type Ii

Drugs & Therapeutics for Lattice Corneal Dystrophy Type Ii

Drugs for Lattice Corneal Dystrophy Type Ii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese Unknown status NCT01842425

Search NIH Clinical Center for Lattice Corneal Dystrophy Type Ii

Genetic Tests for Lattice Corneal Dystrophy Type Ii

Genetic tests related to Lattice Corneal Dystrophy Type Ii:

# Genetic test Affiliating Genes
1 Meretoja Syndrome 30 GSN

Anatomical Context for Lattice Corneal Dystrophy Type Ii

MalaCards organs/tissues related to Lattice Corneal Dystrophy Type Ii:

42
Eye, Skin, Liver

Publications for Lattice Corneal Dystrophy Type Ii

Articles related to Lattice Corneal Dystrophy Type Ii:

# Title Authors Year
1
Meretoja Syndrome: General Considerations and Contributions of Plastic Surgery in Surgical Treatment. ( 29149274 )
2017
2
Corneal melt in lattice corneal dystrophy type II after cataract surgery. ( 19101443 )
2009
3
Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family. ( 17534828 )
2007
4
Confocal microscopy in Meretoja syndrome. ( 11973384 )
2002
5
Lattice corneal dystrophy type II associated with familial amyloid polyneuropathy type IV. ( 8684801 )
1996
6
Lattice corneal dystrophy type II with familial amyloid polyneuropathy type IV. ( 8145387 )
1993
7
Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II. ( 1658654 )
1991
8
Clinical and histopathologic studies of two families with lattice corneal dystrophy and familial systemic amyloidosis (Meretoja syndrome). ( 1923356 )
1991
9
Meretoja syndrome. Lattice dystrophy of the cornea with hereditary generalized amyloidosis. ( 314081 )
1979

Variations for Lattice Corneal Dystrophy Type Ii

Expression for Lattice Corneal Dystrophy Type Ii

Search GEO for disease gene expression data for Lattice Corneal Dystrophy Type Ii.

Pathways for Lattice Corneal Dystrophy Type Ii

GO Terms for Lattice Corneal Dystrophy Type Ii

Sources for Lattice Corneal Dystrophy Type Ii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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