Learning Disability

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Learning Disability

MalaCards integrated aliases for Learning Disability:

Name: Learning Disability 12 15
Learning Disabilities 54 29 6 43 15 72
Learning Disorders 55 44 72
Academic Skill Disorder 12
Learning Disorder 12


External Ids:

Disease Ontology 12 DOID:8927
MeSH 44 D007859
NCIt 50 C89334
SNOMED-CT 68 1855002
ICD10 33 F81.9
UMLS 72 C0023186 C0751265

Summaries for Learning Disability

MedlinePlus : 43 What is a learning disability? Learning disabilities are conditions that affect the ability to learn. They can cause problems with Understanding what people are saying Speaking Reading Writing Doing math Paying attention Often, children have more than one kind of learning disability. They may also have another condition, such as attention deficit hyperactivity disorder (ADHD), which can make learning even more of a challenge. What causes learning disabilities? Learning disabilities don't have anything to do with intelligence. They are caused by differences in the brain, and they affect the way the brain processes information. These differences are usually present at birth. But there are certain factors that can play a role in the development of a learning disability, including Genetics Environmental exposures (such as lead) Problems during pregnancy (such as the mother's substance abuse) How do I know if my child has a learning disability? The earlier you can find and treat a learning disability, the better. Unfortunately, learning disabilities are usually not recognized until a child is in school. If you notice that your child is struggling, talk to your child's teacher or health care provider about an evaluation for a learning disability. The evaluation may include a medical exam, a discussion of family history, and intellectual and school performance testing. What are the treatments for learning disabilities? The most common treatment for learning disabilities is special education. A teacher or other learning specialist can help your child learn skills by building on strengths and finding ways to make up for weaknesses. Educators may try special teaching methods, make changes to the classroom, or use technologies that can assist your child's learning needs. Some children also get help from tutors or speech or language therapists. A child with a learning disability may struggle with low self-esteem, frustration, and other problems. Mental health professionals can help your child understand these feelings, develop coping tools, and build healthy relationships. If your child has another condition such as ADHD, he or she will need treatment for that condition as well. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Learning Disability, also known as learning disabilities, is related to neurofibromatosis, type iv, of riccardi and alacrima, achalasia, and mental retardation syndrome. An important gene associated with Learning Disability is FIBP (FGF1 Intracellular Binding Protein), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Aripiprazole and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Disease Ontology : 12 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.

NINDS : 54 Learning disabilities are disorders that affect the ability to understand or use spoken or written language, do mathematical calculations, coordinate movements, or direct attention. Although learning disabilities occur in very young children, the disorders are usually not recognized until the child reaches school age. Research shows that 8 to 10 percent of American children under 18 years of age have some type of learning disability.

Wikipedia : 75 Learning disability, learning disorder or learning difficulty (British English) is a condition in the... more...

Related Diseases for Learning Disability

Diseases related to Learning Disability via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 30.8 PTPN11 OMG NF1
2 alacrima, achalasia, and mental retardation syndrome 30.3 PURA MECP2 IQSEC2 FMR1
3 disease of mental health 30.3 MECP2 MAPT FMR1
4 epilepsy, x-linked, with variable learning disabilities and behavior disorders 12.7
5 specific learning disability 12.6
6 sotos syndrome 1 12.0
7 shprintzen omphalocele syndrome 11.9
8 giacheti syndrome 11.6
9 feingold syndrome 1 11.6
10 dysgraphia 11.6
11 fragile x syndrome 11.6
12 neurofibromatosis, type i 11.5
13 grange syndrome 11.5
14 turner syndrome 11.5
15 47,xyy 11.5
16 dyslexia 11.5
17 prader-willi syndrome 11.5
18 digeorge syndrome 11.5
19 silver-russell syndrome 11.4
20 velocardiofacial syndrome 11.4
21 dyscalculia 11.4
22 speech and communication disorders 11.4
23 down syndrome 11.3
24 reading disorder 11.3
25 writing disorder 11.3
26 saethre-chotzen syndrome 11.3
27 neural tube defects 11.3
28 cerebellar hypoplasia 11.3
29 histidinemia 11.3
30 thauvin-robinet-faivre syndrome 11.3
31 fetal alcohol syndrome 11.3
32 legius syndrome 11.3
33 microphthalmia, syndromic 3 11.1
34 bloom syndrome 11.1
35 robin sequence with cleft mandible and limb anomalies 11.1
36 osteopathia striata with cranial sclerosis 11.1
37 neuropathy, ataxia, and retinitis pigmentosa 11.1
38 pierpont syndrome 11.1
39 glut1 deficiency syndrome 1 11.1
40 perrault syndrome 3 11.1
41 leukoencephalopathy with ataxia 11.1
42 myopathy with extrapyramidal signs 11.1
43 bardet-biedl syndrome 12 11.1
44 retinal dystrophy, juvenile cataracts, and short stature syndrome 11.1
45 glycosylphosphatidylinositol biosynthesis defect 17 11.1
46 48,xxyy syndrome 11.1
47 spastic paraplegia 20, autosomal recessive 11.0
48 apert syndrome 11.0
49 atelosteogenesis, type iii 11.0
50 centralopathic epilepsy 11.0

Graphical network of the top 20 diseases related to Learning Disability:

Diseases related to Learning Disability

Symptoms & Phenotypes for Learning Disability

GenomeRNAi Phenotypes related to Learning Disability according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 8.8 TBL1XR1
2 Decreased CDKN1A mRNA expression GR00389-S-2 8.8 MECP2 TBL1XR1

MGI Mouse Phenotypes related to Learning Disability:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 CDH8 CLPP FMR1 MAPT MECP2 MYCN
2 growth/size/body region MP:0005378 10.34 CLPP FMR1 MAPT MECP2 MEIS2 MYCN
3 homeostasis/metabolism MP:0005376 10.3 CLPP COLEC11 MAPT MECP2 MYCN NF1
4 cellular MP:0005384 10.28 CLPP FMR1 MAPT MECP2 MEIS2 MYCN
5 cardiovascular system MP:0005385 10.25 MAPT MECP2 MEIS2 MYCN NF1 NPAS3
6 immune system MP:0005387 10.13 CLPP COLEC11 MAPT MECP2 NF1 NPAS3
7 nervous system MP:0003631 10.13 CDH8 FMR1 MAPT MECP2 MEIS2 MYCN
8 endocrine/exocrine gland MP:0005379 10.11 CLPP FMR1 MECP2 NF1 PSAP PTPN11
9 craniofacial MP:0005382 10.07 MAPT MECP2 MEIS2 MYCN NF1 PTPN11
10 integument MP:0010771 10.01 CDH8 CLPP FMR1 MAPT MECP2 NF1
11 liver/biliary system MP:0005370 9.97 MECP2 MEIS2 MYCN NF1 PSAP PTPN11
12 hearing/vestibular/ear MP:0005377 9.95 MECP2 MEIS2 NF1 PSAP PTPN11 RPS6KA3
13 normal MP:0002873 9.86 MAPT MECP2 MYCN NF1 OMG PHOX2B
14 respiratory system MP:0005388 9.81 MECP2 MYCN NF1 NPAS3 PHOX2B PSAP
15 skeleton MP:0005390 9.56 CLPP MECP2 MEIS2 MYCN NF1 PSAP
16 vision/eye MP:0005391 9.36 CDH8 FMR1 MAPT MECP2 MEIS2 MYCN

Drugs & Therapeutics for Learning Disability

Drugs for Learning Disability (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 165)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Sodium citrate Approved, Investigational Phase 4 68-04-2
Caffeine Approved Phase 4 58-08-2 2519
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Testosterone enanthate Approved Phase 4 315-37-7 9416
Methyltestosterone Approved Phase 4 58-18-4 6010
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
18 Psychotropic Drugs Phase 4
19 Serotonin Antagonists Phase 4
20 Tranquilizing Agents Phase 4
21 Serotonin Agents Phase 4
22 Antipsychotic Agents Phase 4
23 Dopamine Antagonists Phase 4
24 Serotonin 5-HT2 Receptor Antagonists Phase 4
25 Serotonin Receptor Agonists Phase 4
26 Serotonin 5-HT1 Receptor Agonists Phase 4
27 Dopamine agonists Phase 4
28 Dopamine D2 Receptor Antagonists Phase 4
29 Antidepressive Agents Phase 4
30 Adrenergic alpha-2 Receptor Agonists Phase 4
31 Adrenergic Agonists Phase 4
32 Adrenergic alpha-Agonists Phase 4
33 Citrate Phase 4
34 Purinergic P1 Receptor Antagonists Phase 4
35 Chelating Agents Phase 4
36 Phosphodiesterase Inhibitors Phase 4
37 Anticoagulants Phase 4
38 Caffeine citrate Phase 4
39 Calcium, Dietary Phase 4
40 Antihypertensive Agents Phase 4
41 Micronutrients Phase 4
42 Trace Elements Phase 4
43 N-monoacetylcystine Phase 4
44 Omega 3 Fatty Acid Phase 4
45 Respiratory System Agents Phase 4
46 Antioxidants Phase 4
47 Antidotes Phase 4
48 Anti-Infective Agents Phase 4
49 Free Radical Scavengers Phase 4
50 Vitamins Phase 4

Interventional clinical trials:

(show top 50) (show all 170)
# Name Status NCT ID Phase Drugs
1 Methylphenidate in Healthy Young Adults Unknown status NCT00815841 Phase 4 METHYLPHENIDATE
2 Aripiprazole Treatment for Antipsychotic Induced Hyperprolactinaemia in Patients With Severe Mental Illness and Learning Disabilities Completed NCT01085383 Phase 4 Aripiprazole
3 Magnetic Resonance Imaging and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine - A Pilot Study Completed NCT00809055 Phase 4 Caffeine citrate
4 Language-based Learning Skills and ADHD: Impact of Treatment With Sustained-release Guanfacine Completed NCT01146002 Phase 4 Guanfacine (sustained release)
5 An Open-Label Clinical Trial Conducted Via Telepsychiatry of Complementary and Alternative Treatments (Omega-3 Fatty Acids and Inositol vs. N-acetylcysteine) for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD) Recruiting NCT03757585 Phase 4 Open-label Treatment with Omega-3 Fatty Acids + Inositol;Open-label Treatment with N-acetylcysteine
6 TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY Recruiting NCT03325647 Phase 4 Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution;Placebo injectable saline
7 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
8 Adaptive Response to Intervention (RTI) for Students With ADHD Recruiting NCT03511976 Phase 4 Stimulant
9 Enhancing Self-Understanding and Social Integration of Middle School Students With Learning Disabilities Unknown status NCT00246792 Phase 2, Phase 3
10 Efficacy of RAD001/Everolimus in Autism and NeuroPsychological Deficits in Children With Tuberous Sclerosis Complex Unknown status NCT01730209 Phase 2, Phase 3 Everolimus;Placebo
11 Prospective Trial of Risperdal (Risperidone) Following Psychological Therapy for Challenging Behaviour in Learning Disabled Children Completed NCT00254930 Phase 3 risperidone
12 Multicenter Double-blind Placebo-Controlled Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children Completed NCT03159104 Phase 3 Tenoten for children;Placebo
13 Effects of Vertical Prism on the Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria: A Randomized, Double-blinded, Placebo-controlled, Cross-over Study Completed NCT00785135 Phase 3
14 Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest Completed NCT00000470 Phase 3
15 Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions: A Randomized-controlled Trial Recruiting NCT03553875 Phase 3 Memantine Hydrochloride;Placebo
16 Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial Recruiting NCT02559102 Phase 3 Dexmedetomidine sedation;General sevoflurane anaesthesia
17 Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants - a Randomized, Double-blind, Placebo-controlled, Prospective, and Multicenter Clinical Study Active, not recruiting NCT02076373 Phase 3 recombinant human Erythropoietin;Placebo
18 Isoflurane-induced Neuroinflammation in Children With Hydrocephalus: A Bench-to-bedside, Translational Study of Molecular Pathways and Therapeutic Approaches Terminated NCT02512809 Phase 3 Isoflurane;Dexmedetomidine
19 Effects of Frequency Modulation (FM) Assistive Listening Device Systems on Listening and Related Skills in Children With Auditory Processing Disorders (APD) Unknown status NCT02353091 Phase 2
20 Preterm Fetal Growth Restriction and Developmental Care Unknown status NCT00166660 Phase 2
21 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Unknown status NCT00513240 Phase 1, Phase 2 Erythropoetin;Normal saline
22 Building Complex Language: Effect of Treatment and Dosage Completed NCT01337232 Phase 1, Phase 2
23 A Phase II Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Escalation Study of NNZ-2566 in Rett Syndrome Completed NCT01703533 Phase 2 NNZ-2566;Placebo
24 A Randomized, Double-blind, Placebo-controlled, Dose-ranging Study of the Safety and Pharmacokinetics of Oral NNZ-2566 in Pediatric Rett Syndrome Completed NCT02715115 Phase 2 NNZ-2566;Placebo
25 Placebo Controlled Trial of Dextromethorphan in Rett Syndrome Completed NCT01520363 Phase 2 dextromethorphan;placebo
26 Investigation of Simvastatin Therapy in Smith-Lemli-Opitz Syndrome Completed NCT00064792 Phase 2 Simvastatin Susp.;OraPlus
27 Neurobiology and Treatment of Reading Disability in NF1 Recruiting NCT02964884 Phase 2 Lovastatin;Placebo Oral Tablet
28 A Randomized, Double-blind, Placebo-controlled, 2-period Crossover Study of BPN14770 in Adult Males With Fragile X Syndrome Recruiting NCT03569631 Phase 2 BPN14770;Placebo
29 Working Memory Training in Attention-Deficit/Hyperactivity Disorder: Neural Mechanisms of Change Unknown status NCT01657721 Phase 1
30 Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1) Completed NCT00352599 Phase 1 Lovastatin;Lovastatin;placebo pill
31 VidRT: Video Distraction During Radiation Therapy to Decrease Use of Pediatric Sedation Recruiting NCT03677531 Phase 1
32 Investigation of Lycra Splinting Garments for Falls and Intellectual Disabilities Unknown status NCT02345512
33 The Contribution of Risk and Resilience Factors in Learning Disabilities Population to Academic and Emotional Development Unknown status NCT01652651
34 Efficacy and Safety of Memantine Hydrochloride, a Low Affinity Antagonist to N-Methyl-D-Aspartate (NMDA) Type Receptors, in the Prevention of Cognitive Decline and Disease Progression in Down’s Syndrome Unknown status NCT00240760 Memantine Hydrochloride
35 The Additive Effect of Cognitive Behavioral Treatment - CBT to Conventional Weight Loss Intervention Program for Young Adults With Intellectual Disabilities Unknown status NCT01032369
36 Topiramate Treatment for Patients With Epilepsy and Learning Disability : A Prospective Observational Study Unknown status NCT00956696 topiramate
37 Teacher Help: Novel Technologies for Meeting the Immediate Needs of Youth With Mental Health Disorders in Canada Unknown status NCT02919215
38 Working Memory Training in College Students With ADHD/LD Unknown status NCT01154686
39 Study of the Neurofibromatosis 1 Expression: Identification of the Modifying Genes Unknown status NCT01650142
40 Longitudinal Assessment of Amyloid Positron Emission Tomography (PET), Fludeoxyglucose F18 (FDG) PET, Tau PET, Magnetic Resonance Imaging (MRI), and Blood Spot Ribonucleic Acid (RNA) in Down Syndrome Individuals With and Without Alzheimer's Dementia and Normal Controls Unknown status NCT02759887
41 Investigating the Effects of an Added Parent Component to Cognitive Behavior Therapy for Youth With Anxiety Disorders Unknown status NCT02160444
42 Development of a New Diagnosis and Intervention Method for Developmental Disorders Unknown status NCT01166152
43 Epidemiological Study for Psychiatric Disorder Among Children and Adolescents Unknown status NCT02707848
44 Identification and Comprehension of Focused Stress in a Sentence Among Adults Who Suffered Traumatic Brain Injury Unknown status NCT02499133
45 Efficacy of External Cold and a Vibrating Device in Reducing Discomfort of Dental Injections in Children - A Split Mouth Randomized Clinical Trial Unknown status NCT02675387 2%Lidocaine
46 Dialectical Behavioral Therapy (DBT) Based Skills Group for Children With Emotional Dysregulation and Their Parents Unknown status NCT01299740
47 Individual Schema-mode Therapy for Anorexia Nervosa: a Pilot Case Series Unknown status NCT02666495
48 A Pilot Randomized Controlled Trial to Test Effectiveness of the ACE4 (Activity Challenge - 4 Areas) for Depression and Anxiety: A Behavioural Activation Based Game. Unknown status NCT02538549
49 Randomized Control Trial of RESOLVE (Relaxation Exercise, SOLving Problem and cognitiVe Errors): A Waiting Room Intervention for Crisis Clients Unknown status NCT02536924
50 Is a Primer Needed for Orthodontic Bonding? A Multi-centre RCT Unknown status NCT01782521

Search NIH Clinical Center for Learning Disability

Cochrane evidence based reviews: learning disorders

Genetic Tests for Learning Disability

Genetic tests related to Learning Disability:

# Genetic test Affiliating Genes
1 Learning Disabilities 29

Anatomical Context for Learning Disability

MalaCards organs/tissues related to Learning Disability:

Brain, Testes, Eye, Heart, Thyroid, Cortex, Temporal Lobe

Publications for Learning Disability

Articles related to Learning Disability:

(show top 50) (show all 7598)
# Title Authors PMID Year
Participation in Peer-Play Activities Among Children With Specific Learning Disability: A Randomized Controlled Trial. 38 17
30915972 2019
Will extra training improve care of service users with learning disabilities or autism? 38 17
30907657 2019
Recognising, managing and supporting dyslexia beyond registration. The lived experiences of qualified nurses and nurse academics. 17
31003874 2019
Hearing impairment as an early sign of alpha-mannosidosis in children with a mild phenotype: Report of seven new cases. 38
31241255 2019
Screening for intellectual disabilities and borderline intelligence in Dutch outpatients with severe mental illness. 38
31033102 2019
Prevalence and Risk Factors of Hypovitaminosis-D in Children with Cognitive and Movement Disorders. 38
31020592 2019
To flag or not to flag: Identification of children and young people with learning disabilities in English hospitals. 38
31095841 2019
New Teachers' Perceptions on Being Prepared to Teach Students With Learning Disabilities: Insights From California. 38
31379273 2019
Anxiety Levels of Children with Developmental Disorders in Japan: Based on Reports Provided by Parents. 38
31177370 2019
A new mouse model of GLUT1-deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain. 38
31399478 2019
Mosaic trisomy 20 and mitigation in capital crimes sentencing: A review and case report. 38
31389076 2019
Estimating local need for mental healthcare to inform fair resource allocation in the NHS in England: cross-sectional analysis of national administrative data linked at person level. 38
31391127 2019
Pathogenic variants in MT-ATP6: A United Kingdom-based mitochondrial disease cohort study. 38
31187502 2019
VAC14 syndrome in two siblings with retinitis pigmentosa and neurodegeneration with brain iron accumulation. 38
31387860 2019
Intellectual functioning in Silver-Russell syndrome: First study in adults. 38
31390893 2019
Speech-Language Disorders in 22q11.2 Deletion Syndrome: Best Practices for Diagnosis and Management. 38
31330115 2019
Academic accommodation strategies for pharmacy students with learning disabilities: What else can be done? 38
31227188 2019
A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome. 38
31145527 2019
Epilepsy surgery. 38
31420415 2019
Epidemiology of children with epilepsy at a tertiary referral centre in South Africa. 38
31323565 2019
Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up. 38
31252277 2019
Delivering a learning disability OSCE station - challenges and solutions. 38
31387466 2019
Preschool deficits in cardinal knowledge and executive function contribute to longer-term mathematical learning disability. 38
31430570 2019
Pattern Perception in Quiet and at Different Signal to Noise Ratio in Children with Learning Disability. 38
31418716 2019
Effect of 4 weeks of frankincense consumption on explicit motor memory and serum BDNF in elderly men 38
31317694 2019
Disability advocacy messaging and conceptual links to underlying disability identity development among college students with learning disabilities and attention disorders. 38
31422170 2019
Health Maintenance in School-Aged Children: Part I. History, Physical Examination, Screening, and Immunizations. 38
31414772 2019
Cognitive phenotype and language skills in children with achondroplasia. 38
26899672 2019
Reading Instruction for Students with Emotional Disturbance: A Mixed-Methods Investigation. 38
31394913 2019
Dental caries experience, care index and restorative index in children with learning disabilities and children without learning disabilities; a systematic review and meta-analysis. 38
31307444 2019
A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex. 38
31217257 2019
Learning disability and obesity: a case report of challenges and reasonable adjustments. 38
31300775 2019
Factors Associated with Recovery in Aboriginal People in Canada Who Had Previously Been Suicidal. 38
31288615 2019
Association between premorbid neuropsychological conditions and pediatric mild traumatic brain injury/concussion recovery time and symptom severity: a systematic review. 38
31305386 2019
Retrospective chart review of spectacle prescription prevalence in adults with learning disabilities in Scotland. 38
30977260 2019
Smart Interactive Education System Based on Wearable Devices. 38
31344920 2019
Neuropsychological outcome following thalamic stroke in adolescence: an identical twin comparison. 38
30472911 2019
Conditional Longitudinal Relations of Elementary Literacy Skills to High School Reading Comprehension. 38
31204614 2019
Economic burden of specific learning disability: A prevalence-based cost of illness study of its direct, indirect, and intangible costs. 38
31169134 2019
Adapting dialectical behaviour therapy in forensic learning disability services: A grounded theory informed study of "what works". 38
30687987 2019
Does Stereotype Threat Deteriorate Academic Performance of High School Students With Learning Disabilities? The Buffering Role of Psychological Disengagement. 38
31122139 2019
'Shining a light on invisibles': Specific learning disabilities and Universal Health Coverage. 38
31317876 2019
Longitudinal Academic Outcomes of Children with Secondary Attention Deficit/Hyperactivity Disorder following Pediatric Stroke. 38
31068020 2019
Multivariate Base Rates of Low Scores and Reliable Decline on ImPACT in Healthy Collegiate Athletes Using CARE Consortium Norms. 38
31272517 2019
Poverty, Toxic Stress, and Education in Children Born Preterm. 38
30913170 2019
Serious Games and Their Effect Improving Attention in Students with Learning Disabilities. 38
31336804 2019
Cognitive profile and disorders affecting higher brain functions in paediatric patients with neurofibromatosis type 1. 38
28431841 2019
Diagnostic Algorithms to Study Post-Concussion Syndrome Using Electronic Health Records: Validating a Method to Capture an Important Patient Population. 38
30773988 2019
Speaking and Reading in Two Languages: On the Identification of Reading and Language Disabilities in Spanish-Speaking English Learners. 38
31271513 2019
Neuropsychology in France. 38
31296054 2019

Variations for Learning Disability

ClinVar genetic disease variations for Learning Disability:

# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FIBP NM_198897.2(FIBP): c.673C> T (p.Gln225Ter) single nucleotide variant Pathogenic/Likely pathogenic rs786204849 11:65652652-65652652 11:65885181-65885181

Expression for Learning Disability

Search GEO for disease gene expression data for Learning Disability.

Pathways for Learning Disability

Pathways related to Learning Disability according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 11.49 RPS6KA3 PTPN11 MAPT
3 11.18 RPS6KA3 PTPN11 NF1

GO Terms for Learning Disability

Cellular components related to Learning Disability according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynapse GO:0098794 9.13 PURA MECP2 FMR1
2 glial cell projection GO:0097386 8.62 MAPT FMR1

Biological processes related to Learning Disability according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 TBL1XR1 RPS6KA3 PHOX2B NPAS3 MYCN MEIS2
2 sympathetic nervous system development GO:0048485 9.26 PHOX2B NF1
3 regulation of gene expression GO:0010468 9.26 TBL1XR1 PHOX2B NF1 MECP2
4 regulation of respiratory gaseous exchange by neurological system process GO:0002087 9.16 PHOX2B MECP2
5 visual learning GO:0008542 8.8 NF1 MEIS2 MECP2

Molecular functions related to Learning Disability according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.28 TBL1XR1 PURA PHOX2B NPAS3 MYCN MEIS2
2 siRNA binding GO:0035197 8.96 MECP2 FMR1

Sources for Learning Disability

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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