MCID: LDD006
MIFTS: 27

Ledderhose Disease

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ledderhose Disease

MalaCards integrated aliases for Ledderhose Disease:

Name: Ledderhose Disease 52 58 71
Plantar Fibromatosis 58 17
Lederhose Disease 52

Characteristics:

Orphanet epidemiological data:

58
ledderhose disease
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

MESH via Orphanet 44 C537000
ICD10 via Orphanet 33 M72.2
UMLS via Orphanet 72 C0158360
Orphanet 58 ORPHA199251
UMLS 71 C0158360

Summaries for Ledderhose Disease

NIH Rare Diseases : 52 Ledderhose disease is a type of plantar fibromatosis characterized by the growth of hard and round or flattened nodules (lumps) on the soles of the feet. It is generally seen in middle-aged and elderly people, and occurs in men about 10 times more often than in women. It typically affects both feet and progresses slowly, but not indefinitely. The nodules are often painless at first, but may cause pain when walking as they grow. People with Ledderhose disease may also have other conditions associated with the formation of excess fibrous connective tissue such as Dupuytren contracture , knuckle pads, or Peyronie disease . Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have also been reported in association with this condition. The exact cause of Ledderhose disease is not known, but heredity is thought to play a role in many cases. Treatment, if needed, may involve conservative management, steroid injections, radiotherapy, or surgery (fasciectomy and removal of the fibrous tissue). The condition has a good prognosis , although slow progression is not uncommon. Fasciectomy has been shown to reduce the rate of recurrence.

MalaCards based summary : Ledderhose Disease, also known as plantar fibromatosis, is related to plantar fascial fibromatosis and dupuytren contracture, and has symptoms including metatarsalgia Affiliated tissues include liver, skin and brain, and related phenotypes are arthralgia and lack of skin elasticity

Wikipedia : 74 Plantar fascial fibromatosis, also known as Ledderhose's disease, Morbus Ledderhose, and plantar... more...

Related Diseases for Ledderhose Disease

Graphical network of the top 20 diseases related to Ledderhose Disease:



Diseases related to Ledderhose Disease

Symptoms & Phenotypes for Ledderhose Disease

Human phenotypes related to Ledderhose Disease:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 lack of skin elasticity 58 31 hallmark (90%) Very frequent (99-80%) HP:0100679
3 paresthesia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003401
4 subcutaneous nodule 58 31 frequent (33%) Frequent (79-30%) HP:0001482
5 peripheral neuropathy 58 Occasional (29-5%)

UMLS symptoms related to Ledderhose Disease:


metatarsalgia

Drugs & Therapeutics for Ledderhose Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ledderhose Disease: Radiotherapy or Not? A Randomised, Multicentre, Prospective, Double Blind Phase III Trial Investigating the Effect of Radiotherapy on Patients With Ledderhose Disease Recruiting NCT03507010 Phase 3
2 Does Fibrosis Diathesis Influence the Recovery of Knee Mobility After Total Knee Replacement? Unknown status NCT02294890

Search NIH Clinical Center for Ledderhose Disease

Genetic Tests for Ledderhose Disease

Anatomical Context for Ledderhose Disease

MalaCards organs/tissues related to Ledderhose Disease:

40
Liver, Skin, Brain, Heart, Tongue

Publications for Ledderhose Disease

Articles related to Ledderhose Disease:

(show top 50) (show all 186)
# Title Authors PMID Year
1
Dupuytren contracture as a sign of systemic disease. 61
31864447 2019
2
The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. 61
31679681 2019
3
Current concepts about treatment options of plantar fibromatosis: A systematic review of the literature. 61
30321942 2019
4
Clinics in diagnostic imaging (195). Plantar fibromatosis. 61
31187147 2019
5
Bilateral Plantar Fibromatosis 61
31243948 2019
6
The etiology, evaluation, and management of plantar fibromatosis. 61
30774465 2019
7
Ledderhose Disease: Pathophysiology Diagnosis and Management. 61
31534943 2019
8
Ultrasonography of Plantar Fibromatosis: Updated Case Series, Review of the Literature, and a Novel Descriptive Appearance Termed the "Comb Sign". 61
29603334 2018
9
Current Concepts Review: Plantar Fibromatosis. 61
29619843 2018
10
Two Genetic Variants Associated with Plantar Fascial Disorders. 61
29534260 2018
11
Plantar Fibromatosis: Pathophysiology, Surgical and Nonsurgical Therapies: An Evidence-Based Review. 61
29310463 2018
12
Plantar fibromatosis: Surgical approach of a giant bilateral case. 61
29265359 2018
13
T2 signal intensity as an imaging biomarker for patients with superficial Fibromatoses of the hands (Dupuytren's disease) and feet (Ledderhose disease) undergoing definitive electron beam irradiation. 61
29085992 2018
14
Clinical, histological and therapeutic modern approach of Ledderhose disease. 61
30534806 2018
15
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. 61
29850357 2018
16
Epithelioid sarcoma of the plantar fascia mimicking Morbus Ledderhose - A severe pitfall for clinical and histopathological misinterpretation. 61
29202999 2017
17
Dupuytren's and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene. 61
29104234 2017
18
Partial fasciectomy is a useful treatment option for symptomatic plantar fibromatosis. 61
28334642 2017
19
Active plantar fibromatosis occurring under anti-TNFα therapy for spondyloarthritis. 61
27324608 2017
20
Malignant tumours of the foot and ankle. 61
28630763 2017
21
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. 61
27655120 2017
22
Imaging of plantar fascia disorders: findings on plain radiography, ultrasound and magnetic resonance imaging. 61
27957702 2017
23
Plantar Fibromatosis and Other Fibroblastic and Fibrohistiocytic Soft Tissue Tumors of the Foot. 61
29461202 2017
24
Plantar Fibromatosis in a Mentally Challenged Man Treated with Intralesional Corticosteroids. 61
29282193 2017
25
Endoscopic Subtotal Fasciectomy of the Foot. 61
28149737 2016
26
An Uncommon Cause of Mid-foot Pain: Ultrasound Imaging for Plantar Fibromatosis and Entrapment of the Lateral Plantar Nerve. 61
27056958 2016
27
Dupuytren-Like Contracture of the Foot: Ledderhose Disease. 61
28825000 2016
28
Zosteriform Collagen Nevus in an Infant. 61
27477177 2016
29
Plantar fibromatosis with flexion contracture and valgus deformity of the great toe. 61
26740438 2016
30
Patient-reported outcomes after electron radiation treatment for early-stage palmar and plantar fibromatosis. 61
26421835 2015
31
Multiple nodules on the sole of the foot. 61
26753144 2015
32
18F-FDG-avid plantar nodules on true whole-body 18F-FDG PET/CT in cancer patients. 61
25932543 2015
33
Ledderhose Disease: Clinical, Radiological (Ultrasound and MRI), and Anatomopathological Findings. 61
26425380 2015
34
Surgical Treatment of a Case of Ledderhose's Disease: A Safe Plantar Approach to Subtotal Fasciectomy. 61
26783478 2015
35
Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children. 61
24821394 2014
36
Ledderhose's disease: radiologic/pathologic correlation of superficial plantar fibromatosis. 61
24630152 2014
37
Collagenase Clostridium histolyticum injection for plantar fibromatosis (Ledderhose disease). 61
25158740 2014
38
Soft tissue angiofibroma: a case report. 61
24113908 2014
39
Squamous cell carcinoma and ledderhose disease: a case report. 61
24214953 2013
40
Plantar fibromatosis--topical review. 61
24043350 2013
41
Superficial plantar fibromatosis. 61
24343216 2013
42
Prevalence of Dupuytren disease in The Netherlands. 61
23897337 2013
43
Association of Morbus Ledderhose with Dupuytren's contracture. 61
23386754 2013
44
Plantar fibromatosis may adopt the brain gyriform pattern of a low-grade fibromyxoid sarcoma. 61
23415764 2013
45
Report of a family with idiopathic knuckle pads and review of idiopathic and disease-associated knuckle pads. 61
24011277 2013
46
Long-term follow-up of flaps for extensive Dupuytren's and Ledderhose disease in one family. 61
22917697 2012
47
Cataracts and Dupuytren disease: a case report and review of the literature. 61
23138664 2012
48
Dupuytren diathesis and genetic risk. 61
23021175 2012
49
High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease). 61
23031080 2012
50
Direct and indirect costs associated with Dupuytren's contracture. 61
22369346 2012

Variations for Ledderhose Disease

Expression for Ledderhose Disease

Search GEO for disease gene expression data for Ledderhose Disease.

Pathways for Ledderhose Disease

GO Terms for Ledderhose Disease

Sources for Ledderhose Disease

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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