MCID: LCH001
MIFTS: 35

Leech Infestation

Categories: Blood diseases, Infectious diseases
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Aliases & Classifications for Leech Infestation

MalaCards integrated aliases for Leech Infestation:

Name: Leech Infestation 11 14 71
Hirudiniasis 11
Leeches 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11079
ICD9CM 34 134.2
SNOMED-CT 68 154423006
ICD10 31 B88.3
UMLS 71 C0019575

Summaries for Leech Infestation

Disease Ontology: 11 A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.

MalaCards based summary: Leech Infestation, also known as hirudiniasis, is related to deficiency anemia and active peptic ulcer disease. An important gene associated with Leech Infestation is ANKRD49 (Ankyrin Repeat Domain 49), and among its related pathways/superpathways are Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drug Antioxidants has been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and ovary, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Leech Infestation

Diseases related to Leech Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.9 PLG F3 F2 CYGB
2 active peptic ulcer disease 29.8 F3 F2 CYGB
3 basilar artery occlusion 10.2 PLG F3
4 retinal artery occlusion 10.2 PLG F2
5 vertebral artery occlusion 10.2 PLG F3
6 middle cerebral artery infarction 10.2 PLG F3
7 anterior spinal artery syndrome 10.2 PLG F2
8 central nervous system origin vertigo 10.2 PLG F2
9 spotted fever 10.2 MT-CO1 F3
10 occlusion precerebral artery 10.2 PLG F3
11 carotid artery thrombosis 10.2 PLG F3
12 thoracic outlet syndrome 10.2 PLG F2
13 achenbach syndrome 10.1 F3 F2
14 pleural empyema 10.1 PLG F2
15 synovial angioma 10.1 F3 F2
16 emphysematous cholecystitis 10.1 F3 F2
17 blue toe syndrome 10.1 F3 F2
18 dic in newborn 10.1 F3 F2
19 giant hemangioma 10.1 F3 F2
20 renal pelvis squamous cell carcinoma 10.1 F3 F2
21 subclavian steal syndrome 10.1 F3 F2
22 waterhouse-friderichsen syndrome 10.1 F3 F2
23 cavernous sinus thrombosis 10.1 F3 F2
24 acalculous cholecystitis 10.1 F3 F2
25 hepatic infarction 10.1 F3 F2
26 qualitative platelet defect 10.1 F3 F2
27 hemopneumothorax 10.1 F3 F2
28 splenic abscess 10.1 F3 F2
29 ureteric orifice cancer 10.1 F3 F2
30 kidney cortex necrosis 10.1 F3 F2
31 prothrombin deficiency 10.1 F3 F2
32 acquired von willebrand syndrome 10.1 F3 F2
33 heparin-induced thrombocytopenia 10.1 F3 F2
34 gastric hemangioma 10.1 F3 F2
35 hepatic coma 10.1 F3 F2
36 ankylosing spondylitis 1 10.1 F3 F2
37 mediastinitis 10.1 F3 F2
38 paralytic ileus 10.1 F3 F2
39 mastoiditis 10.1 F3 F2
40 clonorchiasis 10.1 MT-CO1 GRN
41 splenic sequestration 10.1 F3 F2
42 cauda equina syndrome 10.1 F3 F2
43 intracranial hypotension 10.1 F3 F2
44 ischemic colitis 10.1 F3 F2
45 acute hemorrhagic encephalitis 10.1 F3 F2
46 coronary thrombosis 10.1 PLG F3
47 analbuminemia 10.1 F3 F2
48 volvulus of midgut 10.1 F3 F2
49 angiodysplasia 10.1 F3 F2
50 non-severe covid-19 10.1 F3 F2

Graphical network of the top 20 diseases related to Leech Infestation:



Diseases related to Leech Infestation

Symptoms & Phenotypes for Leech Infestation

MGI Mouse Phenotypes related to Leech Infestation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 ADAM10 AMH CYGB F2 F3 GRN
2 growth/size/body region MP:0005378 9.28 ADAM10 AMH CYGB F2 F3 FAM107B

Drugs & Therapeutics for Leech Infestation

Drugs for Leech Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antioxidants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Risk Benefit Ratio of Hirudotherapy: Retrospective Single-center Study of 37 Cases Over a Period of 9 Years Completed NCT04676581
2 Investigation of Oxidant-antioxidant Status in Patients Treated With Hirudotherapy Completed NCT05438901

Search NIH Clinical Center for Leech Infestation

Genetic Tests for Leech Infestation

Anatomical Context for Leech Infestation

Organs/tissues related to Leech Infestation:

MalaCards : Salivary Gland, Skin, Ovary, Trachea, Eye, Heart, Brain

Publications for Leech Infestation

Articles related to Leech Infestation:

(show top 50) (show all 1560)
# Title Authors PMID Year
1
An Unusual Cause of Recurrent Epistaxis: Nasal Leech Infestation. 62
33393821 2023
2
Phylogenetic relationships and species delimitation in Haemopis (Annelida: Hirudinea: Haemopidae). 62
36283573 2023
3
QAMS-based Simultaneous determination and quality assessment of nucleoside analogs from Qi Zhi capsules. 62
36461617 2022
4
Hirudotherapy in Wound Healing. 62
32815407 2022
5
Cryptic taxonomic diversity and high-latitude melanism in the glossiphoniid leech assemblage from the Eurasian Arctic. 62
36450804 2022
6
Morganella Morganii Infection in Hirudo Medicinalis (Iran): A Case Report. 62
36288175 2022
7
Nasal leeches and epistaxis: A case series. 62
36259222 2022
8
Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis. 62
36006484 2022
9
Insights into gut microbiota communities of Poecilobdella manillensis, a prevalent Asian medicinal leech. 62
35262268 2022
10
Hirudinea (Annelida) Fauna of Some Wetlands in Bingöl Province 62
36094126 2022
11
Stormwater ponds as an amphibian breeding site: a case study with European green toad tadpoles. 62
36104646 2022
12
Study on the regulatory effect of leech peptide HE-D on macrophages in atherosclerosis by transcriptome sequencing. 62
35589020 2022
13
Effects of mammalian blood with different glucose levels on reproduction, growth and survival of the southern medicinal leech, Hirudo verbana Carena, 1820. 62
35780744 2022
14
Life history strategies of Cotylurus spp. Szidat, 1928 (Trematoda, Strigeidae) in the molecular era - Evolutionary consequences and implications for taxonomy. 62
35733618 2022
15
Lethal Aeromonas veronii Sepsis in the Course of Medicinal Leech Therapy. 62
36139958 2022
16
Bronchoscopic removal of a leech from the trachea by cryotherapy. 62
35801687 2022
17
Leeches and Caudal Analgesia After Replantation for Glans Amputation During Neonatal Circumcision. 62
35263644 2022
18
Esophageal hirudiniasis: an unusual cause of upper gastrointestinal bleeding. 62
35910000 2022
19
Implementation of a Leeches + Antimicrobial Prophylaxis Order Panel to Optimize Medicinal Leech Use at a Tertiary Care Academic Medical Center. 62
33563061 2022
20
Ozobranchus jantseanus (Clitellata: Ozobranchidae) from Reeve's Turtle, Mauremys reevesii: New Annelid Fauna in Korea. 62
35772741 2022
21
Serotonin mediates stress-like effects on responses to non-nociceptive stimuli in the medicinal leech Hirudo verbana. 62
35510636 2022
22
Measuring ethical behavior with AI and natural language processing to assess business success. 62
35715458 2022
23
Utilization of Leech Therapy after Rhinoplasty. 62
35383721 2022
24
From ancient leech to direct thrombin inhibitors and beyond: New from old. 62
35364378 2022
25
Population Genetic Structure of Marine Leech, Pterobdella arugamensis in Indo-West Pacific Region. 62
35741718 2022
26
Improvement of patient care through hirudotherapy and the management of leeches from their reception to their disposal in France. 62
35501036 2022
27
Novel bioavailability-based risk assessment of Cd in earthworms and leeches utilizing in vitro digestion/Caco-2 and MDCK cells. 62
34859344 2022
28
Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke. 62
35416530 2022
29
Examination of Rickettsial Host Range for Shuttle Vectors Based on dnaA and parA Genes from the pRM Plasmid of Rickettsia monacensis. 62
35323021 2022
30
Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra Whitman. 62
35032585 2022
31
A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. 62
34863800 2022
32
Measuring protected-area effectiveness using vertebrate distributions from leech iDNA. 62
35322033 2022
33
The present state of the leech fauna (Annelida: Hirudinea) in Lithuania. 62
35391381 2022
34
The potential of aquatic bloodfeeding and nonbloodfeeding leeches as a tool for iDNA characterisation. 62
34402209 2022
35
[Cutaneous pseudolymphoma after hirudotherapy : Case report and review]. 62
33884433 2022
36
Intraoral Hirudotherapy for Venous Congestion following Free Flap Head and Neck Reconstruction: Novel Intraoral Technique. 62
34293746 2022
37
A new species of medicinal leech in the genus Hirudo Linnaeus, 1758 (Hirudiniformes, Hirudinidae) from Tianjin City, China. 62
35836684 2022
38
Bloody Wiggler, a Case Report of a Leech in the Pharynx. 62
36164319 2022
39
Comprehensive Transcriptome Sequencing Analysis of Hirudinaria manillensis in Different Growth Periods. 62
35694407 2022
40
The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients. 62
35073842 2022
41
First data on the Hirudinea fauna of lotic ecosystems of the Khanty-Mansi Autonomous Area (Russia). 62
35115865 2022
42
Rethinking antimicrobial prophylaxis in patients receiving medicinal leech therapy. 62
34390241 2022
43
Intersegmental Interactions Give Rise to a Global Network. 62
35282329 2022
44
Cellulitis Caused by Hirudo orientalis Bites That Lead to an Allergic reaction. 62
36317193 2022
45
Validation of Medicinal Leeches (Hirudo medicinalis) as a Non-invasive Blood Sampling Tool for Hematology and Biochemistry Profiling in Mammals. 62
35187150 2022
46
Glossiphoniid leeches as a touchstone for studies of development in clitellate annelids. 62
35337458 2022
47
Comparison of body wall histologic structure of two medicinal leeches Hirudo sulukii and Hirudo verbana (Hirudinida: Hirudinidae). 62
34725716 2022
48
Upper GI Bleeding Due to Leech Infestation in Ethiopian Patients: A Case Series and Review of Literature. 62
36452264 2022
49
Laryngeal Leech Infestation: A Rare Cause of Upper Air Way Obstruction in Children. 62
36388240 2022
50
Case Report: Endoscope-Assisted Bilateral Nasal Leech Retrieval in a Dog. 62
35968014 2022

Variations for Leech Infestation

Expression for Leech Infestation

Search GEO for disease gene expression data for Leech Infestation.

Pathways for Leech Infestation

Pathways related to Leech Infestation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 PLG F3 F2
2
Show member pathways
11.87 PLG F2 ADAM10
3 11.22 PLG F3 ADAM10
4 10.94 F3 F2
5 10.75 PLG F2
6 10.52 PLG ADAM10
7 9.47 PLG F2

GO Terms for Leech Infestation

Biological processes related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.56 PLG F2
2 negative regulation of fibrinolysis GO:0051918 9.46 PLG F2
3 blood coagulation GO:0007596 9.43 PLG F3 F2
4 hemostasis GO:0007599 8.8 PLG F3 F2

Molecular functions related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.23 PLG F2 AMH ADAM10

Sources for Leech Infestation

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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