MCID: LCH001
MIFTS: 40

Leech Infestation

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Leech Infestation

MalaCards integrated aliases for Leech Infestation:

Name: Leech Infestation 12 15 72
Hirudiniasis 12
Leeches 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11079
ICD9CM 35 134.2
SNOMED-CT 68 64351000
ICD10 33 B88.3
UMLS 72 C0019575

Summaries for Leech Infestation

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.

MalaCards based summary : Leech Infestation, also known as hirudiniasis, is related to heart disease and acquired hemophilia. An important gene associated with Leech Infestation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tacrolimus and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and brain, and related phenotypes are cardiovascular system and reproductive system

Wikipedia : 75 Leeches are segmented parasitic or predatory worms that belong to the phylum Annelida and comprise the... more...

Related Diseases for Leech Infestation

Diseases related to Leech Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 heart disease 29.0 SERPINC1 PF4 FLNA F3 F2
2 acquired hemophilia 10.5 F3 F10
3 carotid artery thrombosis 10.5 F3 F10
4 retinal artery occlusion 10.5 SERPINC1 F2
5 hemophilia 10.5 F3 F2
6 prothrombin deficiency 10.5 F3 F2
7 conjugate gaze palsy 10.5 PLG F3
8 spinal cord infarction 10.5 SERPINC1 F2
9 factor xii deficiency 10.4 SERPINC1 F3
10 pulmonary immaturity 10.4 SERPINC1 F3
11 ischemic colitis 10.4 SERPINC1 F2
12 coronary thrombosis 10.4 SERPINC1 F3
13 subendocardial myocardial infarction 10.4 SERPINC1 F2
14 sneddon syndrome 10.4 SERPINC1 F2
15 cerebral sinovenous thrombosis 10.4 F3 F2
16 dysbaric osteonecrosis 10.4 PLG F3
17 osteonecrosis 10.4 SERPINC1 F2
18 qualitative platelet defect 10.4 F3 F2
19 esophageal varix 10.4 SERPINC1 F2
20 thrombophlebitis 10.4 SERPINC1 F2
21 hantavirus pulmonary syndrome 10.4 F3 F2
22 alcohol-related birth defect 10.4 F3 F2
23 vertebral artery occlusion 10.4 PLG F3
24 von willebrand disease, type 1 10.4 F3 F2
25 hypersplenism 10.4 SERPINC1 F2
26 platelet aggregation, spontaneous 10.4 SERPINC1 PF4
27 cold urticaria 10.4 SERPINC1 PF4
28 post-thrombotic syndrome 10.4 SERPINC1 F2
29 splenic disease 10.4 F3 F2
30 central retinal vein occlusion 10.4 SERPINC1 F2
31 hemophilia a 10.4 F3 F10
32 retinal vein occlusion 10.4 SERPINC1 F2
33 lemierre's syndrome 10.4 PLG F3
34 mitral valve stenosis 10.3 SERPINC1 PF4
35 portal vein thrombosis 10.3 SERPINC1 F2
36 heparin-induced thrombocytopenia 10.3 SERPINC1 F3 F10
37 dysfibrinogenemia 10.3 SERPINC1 F2
38 posterolateral myocardial infarction 10.3 PLG PF4
39 deficiency anemia 10.3
40 anteroseptal myocardial infarction 10.3 PLG PF4
41 analbuminemia 10.3 F3 F2
42 placental abruption 10.2 SERPINC1 F2
43 squamous cell papilloma 10.2 F3 F2
44 scott syndrome 10.2 F2 F10
45 lung disease 10.2
46 protein c deficiency 10.2 SERPINC1 F2
47 intracranial thrombosis 10.2 SERPINC1 PLG F3
48 lateral medullary syndrome 10.2 PLG PF4
49 intermediate coronary syndrome 10.2 SERPINC1 PLG F3
50 dysphagia 10.2

Graphical network of the top 20 diseases related to Leech Infestation:



Diseases related to Leech Infestation

Symptoms & Phenotypes for Leech Infestation

MGI Mouse Phenotypes related to Leech Infestation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 F10 F2 F3 FLNA PLG SERPINC1
2 reproductive system MP:0005389 9.17 C1orf56 F10 F2 FLNA PLG SERPINC1

Drugs & Therapeutics for Leech Infestation

Drugs for Leech Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
2
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
3 glucocorticoids
4 Hormones
5 Immunologic Factors
6 Hormone Antagonists
7 Immunosuppressive Agents
8 Cyclosporins
9 Hormones, Hormone Substitutes, and Hormone Antagonists
10 Flax
11 Hirudins
12 Anesthetics
13 Anticoagulants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanism Research of Traditional Chinese Medicine (the Comprehensive Treatment Regimen) in Treating Idiopathic Membranous Nephropathy by Genomewide Association Studies Unknown status NCT01799460 The Comprehensive Treatment Regimen of Traditional Chinese Medicine;The immunosuppressive agents
2 EVALUATION OF THE CYTOTOXICITY AND GLYCEMIC CONTROL OF SUBJECTS WITH METABOLIC SYNDROME MANAGED WITH CONVENTIONAL NUTRITIONAL TREATMENT MORE QUINOA, LINAZA OR BOTH VERSUS CONVENTIONAL NUTRITIONAL Not yet recruiting NCT03915600
3 Pilot Study on the Influence of Leech Therapy on Pain and Sensory Processing in Patients With Postherpetic Neuralgia Terminated NCT01744522

Search NIH Clinical Center for Leech Infestation

Genetic Tests for Leech Infestation

Anatomical Context for Leech Infestation

MalaCards organs/tissues related to Leech Infestation:

41
Skin, Salivary Gland, Brain, Heart, Eye, Testes, Breast

Publications for Leech Infestation

Articles related to Leech Infestation:

(show top 50) (show all 1335)
# Title Authors PMID Year
1
The salivary transcriptome of Limnobdella mexicana (Annelida: Clitellata: Praobdellidae) and orthology determination of major leech anticoagulants. 38
31148528 2019
2
Parasitism offers large rewards but carries high risks: Predicting parasitic strategies under different life history conditions in lampreys. 38
31021026 2019
3
Electrophysiology and transcriptomics reveal two photoreceptor classes and complex visual integration in Hirudo verbana. 38
31262786 2019
4
Feedback to the future: motor neuron contributions to central pattern generator function. 38
31420449 2019
5
Reachability Improvement of a Climbing Robot Based on Large Deformations Induced by Tri-Tube Soft Actuators. 38
30917091 2019
6
Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3. 38
31409011 2019
7
First record of infestation by nasal leeches, Limnatis nilotica (Hirudinida, Praobdellidae), from cattle in Italy. 38
31391384 2019
8
Spatiotemporal Expression of Anticoagulation Factor Antistasin in Freshwater Leeches. 38
31426335 2019
9
Anal abscess due to leech therapy of hemorrhoids: mumbo jumbo is still in vogue. 38
31384426 2019
10
Management of Upper Airway Leech Infestations. 38
31266401 2019
11
Investigation of reproductive efficiency, growth performance and survival of the southern medicinal leech, Hirudo verbana Carena, 1820 fed with mammalian and poultry blood. 38
31103350 2019
12
Phylogenomic Analysis of a Putative Missing Link Sparks Reinterpretation of Leech Evolution. 38
31214691 2019
13
Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman. 38
31361480 2019
14
Hirudin and Decorsins of the North American Medicinal Leech Macrobdella decora: Gene Structure Reveals Homology to Hirudins and Hirudin-like Factors of Eurasian Medicinal Leeches. 38
31163003 2019
15
Leeches attenuate blood hyperviscosity and related metabolic disorders in rats differently than aspirin. 38
30910578 2019
16
Microscopic analysis of spermatogenesis and mature spermatozoa in the amphibian leech Batracobdella algira (Annelida, Clitellata, Hirudinida). 38
31254071 2019
17
Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp. 38
31088523 2019
18
Leeches from Mexico City, remnants of the ancient lake. 38
31072187 2019
19
Leech (Myzobdella lugubris) infestations in largemouth bass (Micropterus salmoides) in Back Bay, Virginia, USA. 38
30972838 2019
20
In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data. 38
30880165 2019
21
Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River. 38
30806729 2019
22
Behavioral analysis of substrate texture preference in a leech, Helobdella austinensis. 38
30721348 2019
23
Transcriptomics and differential gene expression in Whitmania pigra (Annelida: Clitellata: Hirudinida: Hirudinidae): Contrasting feeding and fasting modes. 38
31031937 2019
24
Admirable Use of Leeches. 38
31130159 2019
25
An efficient and robust laboratory workflow and tetrapod database for larger scale environmental DNA studies. 38
30997489 2019
26
Pediatric Vaginal Leech Infestation with Severe Bleeding: A Case Report and Review Article. 38
30928531 2019
27
Oral administration of leeches (Shuizhi): A review of the mechanisms of action on antiplatelet aggregation. 38
30543914 2019
28
Spatio-temporal variation and the use of host body surface by ectoparasites of the chelonians Phrynops geoffroanus and Mesoclemmys tuberculata in areas of the Caatinga and Atlantic Forest in northeast Brazil. 38
30737672 2019
29
Unusual Case of Penile Ecchymosis. 38
29189594 2019
30
DNA Barcoding Reveals Association of Glossiphoniidae Species on Endangered Freshwater Turtles in Northeast India. 38
30644063 2019
31
Reproductive differences among species, and between individuals and cohorts, in the leech genus Helobdella (Lophotrochozoa; Annelida; Clitellata; Hirudinida; Glossiphoniidae), with implications for reproductive resource allocation in hermaphrodites. 38
30934006 2019
32
Using metabarcoding to compare the suitability of two blood-feeding leech species for sampling mammalian diversity in North Borneo. 38
30225935 2019
33
AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech. 38
30368505 2019
34
Microglia: The Neural Cells of Nonneural Origin. 38
31392673 2019
35
Ehrlichia species in pond-farmed leeches (Hirudinaria sp.) in Hubei Province, China. 38
30958857 2019
36
On the origin of leeches by evolution of development. 38
30393850 2019
37
Ideating iDNA: Lessons and limitations from leeches in legacy collections. 38
30794582 2019
38
A Rare Cause of Hypovolemic Shock in Prepubertal Girl: Vaginal Leech Infestation. 38
31346483 2019
39
Revisiting Medicinal Leeches. 38
30935189 2019
40
Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding. 38
30626071 2019
41
[A Case of Medical Leech Therapy for Venous Congestion Following Forearm Flap Reconstruction]. 38
30692309 2018
42
Debugging diversity - a pan-continental exploration of the potential of terrestrial blood-feeding leeches as a vertebrate monitoring tool. 38
29877042 2018
43
Influence of earthworms on the nitrogen transfer of sewage sludge in the vermifilter process. 38
30182315 2018
44
The Effectiveness of Leech Therapy in Chronic Low Back Pain. 38
30636672 2018
45
Leeching as Salvage Venous Drainage in Ear Reconstruction: Clinical Case and Review of Literature. 38
30881774 2018
46
Leeches-Inspired Hydrogel-Elastomer Integration Materials. 38
30215503 2018
47
Cadmium selenide quantum dot-zinc oxide composite: Synthesis, characterization, dye removal ability with UV irradiation, and antibacterial activity as a safe and high-performance photocatalyst. 38
30195976 2018
48
Pediatric Vulvar Bleeding due to Leech Infestation: A Case Report. 38
30697323 2018
49
The Use of Medicinal Leeches for the Treatment of Venous Congestion in Replanted or Revascularized Digits. 38
29602653 2018
50
Hard to be killed: Load-bearing capacity of the leech Hirudo nipponia. 38
30007183 2018

Variations for Leech Infestation

Expression for Leech Infestation

Search GEO for disease gene expression data for Leech Infestation.

Pathways for Leech Infestation

GO Terms for Leech Infestation

Cellular components related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.56 SERPINC1 PLG PF4 F3
2 endoplasmic reticulum lumen GO:0005788 9.54 SERPINC1 F2 F10
3 blood microparticle GO:0072562 9.5 SERPINC1 PLG F2
4 extracellular space GO:0005615 9.5 SERPINC1 PLG PF4 F3 F2 F10
5 extracellular region GO:0005576 9.28 SERPINC1 PLG PF4 FLNA F3 F2
6 intrinsic component of external side of plasma membrane GO:0031233 9.16 F3 F10

Biological processes related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 SERPINC1 PLG F2
2 platelet degranulation GO:0002576 9.58 PLG PF4 FLNA
3 platelet activation GO:0030168 9.5 PF4 FLNA F2
4 fibrinolysis GO:0042730 9.43 PLG F2
5 regulation of blood coagulation GO:0030193 9.37 SERPINC1 F2
6 blood coagulation GO:0007596 9.35 SERPINC1 PLG F3 F2 F10
7 negative regulation of fibrinolysis GO:0051918 9.26 PLG F2
8 blood coagulation, extrinsic pathway GO:0007598 9.16 F3 F10
9 hemostasis GO:0007599 9.02 SERPINC1 PLG F3 F2 F10

Molecular functions related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.33 SERPINC1 PF4 F2
2 serine-type peptidase activity GO:0008236 9.13 PLG F2 F10
3 serine-type endopeptidase activity GO:0004252 8.92 PLG F3 F2 F10

Sources for Leech Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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