MCID: LCH001
MIFTS: 36

Leech Infestation

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Leech Infestation

MalaCards integrated aliases for Leech Infestation:

Name: Leech Infestation 12 15 71
Hirudiniasis 12
Leeches 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11079
ICD9CM 34 134.2
SNOMED-CT 67 64351000
ICD10 32 B88.3
UMLS 71 C0019575

Summaries for Leech Infestation

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.

MalaCards based summary : Leech Infestation, also known as hirudiniasis, is related to retinal artery occlusion and platelet aggregation, spontaneous. An important gene associated with Leech Infestation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Microglia Activation During Neuroinflammation: Overview. The drugs Tacrolimus and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, salivary gland and skin.

Wikipedia : 74 Leeches are segmented parasitic or predatory worms that belong to the phylum Annelida and comprise the... more...

Related Diseases for Leech Infestation

Diseases related to Leech Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 retinal artery occlusion 10.4 SERPINC1 PLG
2 platelet aggregation, spontaneous 10.4 SERPINC1 PF4
3 cold urticaria 10.4 SERPINC1 PF4
4 puerperal pulmonary embolism 10.4 SERPINC1 F10
5 prothrombin deficiency, congenital 10.4 SERPINC1 F10
6 alveolar periostitis 10.3 PLG PF4
7 livedoid vasculitis 10.3 SERPINC1 PLG
8 thoracic outlet syndrome 10.3 SERPINC1 PLG
9 cholesterol embolism 10.3 SERPINC1 PLG
10 alpha-2-plasmin inhibitor deficiency 10.3 SERPINC1 PLG
11 deficiency anemia 10.3
12 fournier gangrene 10.3 SERPINC1 F3
13 vulvar angiokeratoma 10.3 SERPINC1 F3
14 central retinal artery occlusion 10.3 SERPINC1 PLG
15 blue toe syndrome 10.3 SERPINC1 F3
16 dic in newborn 10.3 SERPINC1 F3
17 hepatic infarction 10.3 SERPINC1 F3
18 posterolateral myocardial infarction 10.3 PLG PF4
19 giant hemangioma 10.3 SERPINC1 F3
20 acquired hemophilia 10.3 F3 F10
21 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 SERPINC1 PLG
22 qualitative platelet defect 10.2 PF4 F3
23 lung disease 10.2
24 volkmann contracture 10.2 SERPINC1 F3
25 splenic infarction 10.2 SERPINC1 F3
26 thrombophlebitis migrans 10.2 SERPINC1 F3
27 dysphagia 10.2
28 acute cor pulmonale 10.2 PLG F3
29 acute pulmonary heart disease 10.2 PLG F3
30 vitamin k deficiency bleeding 10.2 SERPINC1 F3
31 hemopericardium 10.2 PLG F3
32 esophageal varix 10.2 SERPINC1 F3
33 hemarthrosis 10.2 F3 F10
34 papilledema 10.1 SERPINC1 F3
35 occlusion precerebral artery 10.1 PLG F3
36 peripheral vertigo 10.1 SERPINC1 F3
37 factor x deficiency 10.1 F3 F10
38 factor xii deficiency 10.1 SERPINC1 F3
39 mitral valve stenosis 10.1 SERPINC1 PF4 F3
40 prothrombin deficiency 10.1 SERPINC1 F3 F10
41 factor v deficiency 10.1 F3 F10
42 factor xi deficiency 10.1 SERPINC1 F3 F10
43 factor vii deficiency 10.1 SERPINC1 F3 F10
44 cystitis cystica 10.1 SPAM1 HYAL1
45 protein s deficiency 10.1 SERPINC1 F3 F10
46 marantic endocarditis 10.1 SERPINC1 PLG F3
47 thrombocytosis 10.1 SERPINC1 PF4 F3
48 intracranial sinus thrombosis 10.1 SERPINC1 PLG F3
49 sagittal sinus thrombosis 10.1 SERPINC1 PLG F3
50 branch retinal artery occlusion 10.1 SERPINC1 PLG F3

Graphical network of the top 20 diseases related to Leech Infestation:



Diseases related to Leech Infestation

Symptoms & Phenotypes for Leech Infestation

Drugs & Therapeutics for Leech Infestation

Drugs for Leech Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
2
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
3 Hormone Antagonists
4 Immunosuppressive Agents
5 Cyclosporins
6 Hormones
7 glucocorticoids
8 Immunologic Factors
9 Flax
10 Anesthetics
11 Anticoagulants
12 Hirudins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanism Research of Traditional Chinese Medicine (the Comprehensive Treatment Regimen) in Treating Idiopathic Membranous Nephropathy by Genomewide Association Studies Unknown status NCT01799460 The Comprehensive Treatment Regimen of Traditional Chinese Medicine;The immunosuppressive agents
2 Evaluation of the Citotoxicity and Clicemic Control of Subject With Metabolic Syndrome Managed With Conventional Nutritional Tratment More Quinoa, Flaxseed or Borh Versus Conventional Nutrition Recruiting NCT03915600
3 Pilot Study on the Influence of Leech Therapy on Pain and Sensory Processing in Patients With Postherpetic Neuralgia Terminated NCT01744522

Search NIH Clinical Center for Leech Infestation

Genetic Tests for Leech Infestation

Anatomical Context for Leech Infestation

MalaCards organs/tissues related to Leech Infestation:

40
Heart, Salivary Gland, Skin, Brain, Eye, Breast, Testes

Publications for Leech Infestation

Articles related to Leech Infestation:

(show top 50) (show all 1354)
# Title Authors PMID Year
1
Genetic variation, pseudocryptic diversity, and phylogeny of Erpobdella (Annelida: Hirudinida: Erpobdelliformes), with emphasis on Canadian species. 61
31747540 2020
2
Barriers and Enabling Factors Associated with the Implementation of Household Solar Water Disinfection: A Qualitative Study in Northwest Ethiopia. 61
31837131 2020
3
PHASE SPECIFIC MOTOR EFFERENCE DURING A RHYTHMIC MOTOR PATTERN. 61
31980584 2020
4
Cutaneous lymphoid hyperplasia induced by Hirudo medicinalis (leeches). 61
31804958 2019
5
Internal and External Morphological Characteristics of the Medicinal Leech Species Hirudo sulukii and Hirudo verbana 61
31865657 2019
6
Microscopic analysis of spermatogenesis and mature spermatozoa in the amphibian leech Batracobdella algira (Annelida, Clitellata, Hirudinida). 61
31254071 2019
7
Freshwater mussels house a diverse mussel-associated leech assemblage. 61
31712612 2019
8
Evolution of mechanisms and behaviour important for pain. 61
31544614 2019
9
The intermediate hosts of Wardium cirrosa (Krabbe, 1869) Spassky, 1961 (Cestoda, Cyclophyllidea, Aploparaksidae) in Ukraine. 61
31612284 2019
10
First record of infestation by nasal leeches, Limnatis nilotica (Hirudinida, Praobdellidae), from cattle in Italy. 61
31391384 2019
11
Presence and survival of African swine fever virus in leeches. 61
31585648 2019
12
Beyond the epistaxis: voluntary nasal leech (Dinobdella ferox) infestation revealed the leech behaviours and the host symptoms through the parasitic period. 61
31190663 2019
13
Broad geographic sampling and DNA barcoding do not support the presence of Helobdella stagnalis (Linnaeus, 1758) (Clitellata: Glossiphoniidae) in North America. 61
31716590 2019
14
The salivary transcriptome of Limnobdella mexicana (Annelida: Clitellata: Praobdellidae) and orthology determination of major leech anticoagulants. 61
31148528 2019
15
Highlights of Medical Entomology 2018: The Importance of Sustainable Surveillance of Vectors and Vector-Borne Pathogens. 61
31505669 2019
16
[Effects of 17β-E2 on growth and gonad development of overwintering Whitmania pigra]. 61
31602878 2019
17
Parasitism offers large rewards but carries high risks: Predicting parasitic strategies under different life history conditions in lampreys. 61
31021026 2019
18
Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3. 61
31409011 2019
19
Reachability Improvement of a Climbing Robot Based on Large Deformations Induced by Tri-Tube Soft Actuators. 61
30917091 2019
20
Electrophysiology and transcriptomics reveal two photoreceptor classes and complex visual integration in Hirudo verbana. 61
31262786 2019
21
Feedback to the future: motor neuron contributions to central pattern generator function. 61
31420449 2019
22
Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman. 61
31361480 2019
23
Pediatric Vaginal Leech Infestation with Severe Bleeding: A Case Report and Review Article. 61
30928531 2019
24
Spatiotemporal Expression of Anticoagulation Factor Antistasin in Freshwater Leeches. 61
31426335 2019
25
Leeches and Plastic Surgery in the Modern Era. 61
31441789 2019
26
Anal abscess due to leech therapy of hemorrhoids: mumbo jumbo is still in vogue. 61
31384426 2019
27
Phylogenomic Analysis of a Putative Missing Link Sparks Reinterpretation of Leech Evolution. 61
31214691 2019
28
Investigation of reproductive efficiency, growth performance and survival of the southern medicinal leech, Hirudo verbana Carena, 1820 fed with mammalian and poultry blood. 61
31103350 2019
29
Management of Upper Airway Leech Infestations. 61
31266401 2019
30
Hirudin and Decorsins of the North American Medicinal Leech Macrobdella decora: Gene Structure Reveals Homology to Hirudins and Hirudin-like Factors of Eurasian Medicinal Leeches. 61
31163003 2019
31
Leeches attenuate blood hyperviscosity and related metabolic disorders in rats differently than aspirin. 61
30910578 2019
32
Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp. 61
31088523 2019
33
Leeches from Mexico City, remnants of the ancient lake. 61
31072187 2019
34
Leech (Myzobdella lugubris) infestations in largemouth bass (Micropterus salmoides) in Back Bay, Virginia, USA. 61
30972838 2019
35
In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data. 61
30880165 2019
36
Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River. 61
30806729 2019
37
An efficient and robust laboratory workflow and tetrapod database for larger scale environmental DNA studies. 61
30997489 2019
38
Transcriptomics and differential gene expression in Whitmania pigra (Annelida: Clitellata: Hirudinida: Hirudinidae): Contrasting feeding and fasting modes. 61
31031937 2019
39
Behavioral analysis of substrate texture preference in a leech, Helobdella austinensis. 61
30721348 2019
40
Admirable Use of Leeches. 61
31130159 2019
41
Oral administration of leeches (Shuizhi): A review of the mechanisms of action on antiplatelet aggregation. 61
30543914 2019
42
Spatio-temporal variation and the use of host body surface by ectoparasites of the chelonians Phrynops geoffroanus and Mesoclemmys tuberculata in areas of the Caatinga and Atlantic Forest in northeast Brazil. 61
30737672 2019
43
Unusual Case of Penile Ecchymosis. 61
29189594 2019
44
DNA Barcoding Reveals Association of Glossiphoniidae Species on Endangered Freshwater Turtles in Northeast India. 61
30644063 2019
45
Vampire in the darkness: a new genus and species of land leech exclusively bloodsucking cave-dwelling bats from China (Hirudinda: Arhynchobdellida: Haemadipsidae). 61
31716579 2019
46
Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding. 61
30626071 2019
47
Reflections on Model Organisms in Evolutionary Developmental Biology. 61
31598850 2019
48
Using metabarcoding to compare the suitability of two blood-feeding leech species for sampling mammalian diversity in North Borneo. 61
30225935 2019
49
Reproductive differences among species, and between individuals and cohorts, in the leech genus Helobdella (Lophotrochozoa; Annelida; Clitellata; Hirudinida; Glossiphoniidae), with implications for reproductive resource allocation in hermaphrodites. 61
30934006 2019
50
Draft Genome of the Asian Buffalo Leech Hirudinaria manillensis. 61
32010187 2019

Variations for Leech Infestation

Expression for Leech Infestation

Search GEO for disease gene expression data for Leech Infestation.

Pathways for Leech Infestation

GO Terms for Leech Infestation

Cellular components related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 SERPINC1 PLG PF4 HYAL1 F3 F10
2 collagen-containing extracellular matrix GO:0062023 9.26 SERPINC1 PLG PF4 F3
3 intrinsic component of external side of plasma membrane GO:0031233 8.62 F3 F10

Biological processes related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.46 SERPINC1 PLG F3 F10
2 sperm-egg recognition GO:0035036 9.32 SPESP1 SPAM1
3 fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342 9.26 SPESP1 SPAM1
4 blood coagulation, extrinsic pathway GO:0007598 8.96 F3 F10
5 hemostasis GO:0007599 8.92 SERPINC1 PLG F3 F10

Molecular functions related to Leech Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 PLG F3 F10
2 hyalurononglucosaminidase activity GO:0004415 8.62 SPAM1 HYAL1

Sources for Leech Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....