Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: LFT001
MIFTS: 47

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Left Bundle Branch Hemiblock

About this section

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 70
Left Bundle Branch Block 12 54 15
Left Bundle-Branch Block 70

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 34 426.2
SNOMED-CT 67 266245009
ICD10 32 I44.60 I44.7
UMLS 70 C0023211 C0155702
Sources

Summaries for Left Bundle Branch Hemiblock

About this section
MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to progressive familial heart block, type ia and arrhythmogenic right ventricular dysplasia, familial, 1. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Cardiac conduction and Cytoskeletal Signaling. The drugs Carvedilol and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and skin, and related phenotypes are cardiovascular system and mortality/aging

Sources

Related Diseases for Left Bundle Branch Hemiblock

About this section

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 32.6 SCN5A DSP
2 arrhythmogenic right ventricular dysplasia, familial, 1 31.7 RYR2 PKP2 DSP DSG2 DSC2
3 second-degree atrioventricular block 31.5 TNNI3 SCN5A
4 third-degree atrioventricular block 31.5 SCN5A NPPB ACE
5 right bundle branch block 31.4 TNNI3 SCN5A PKP2 NPPB DSG2 ACE
6 syncope 31.3 TNNT2 SCN5A RYR2
7 systolic heart failure 31.2 NR3C2 NPPB CRP ACE
8 arteries, anomalies of 31.1 TNNI3 REN CRP ACE
9 inferior myocardial infarction 31.1 TNNI3 PIK3C2A NPPB ACE
10 anterolateral myocardial infarction 31.1 NPPB ACE
11 first-degree atrioventricular block 31.1 SCN5A NPPB LMNA CRP ACE
12 wolff-parkinson-white syndrome 31.0 TNNT2 TNNT1 TNNI3 SCN5A NPPB
13 coronary stenosis 31.0 TNNI3 PIK3C2A NPPB CRP ACE
14 anteroseptal myocardial infarction 30.9 PIK3C2A ACE
15 angina pectoris 30.9 TNNI3 PIK3C2A NPPB CRP ACE
16 acute myocardial infarction 30.9 TNNT2 TNNI3 PIK3C2A NPPB ITGA2B CRP
17 atrioventricular block 30.8 TNNI3 SCN5A RYR2 PIK3C2A NPPB LMNA
18 infective endocarditis 30.8 TNNT2 TNNI3 CRP
19 myocarditis 30.7 TNNI3 PIK3C2A NPPB DSP ACE
20 urinary tract infection 30.7 CRP ACE
21 ventricular fibrillation, paroxysmal familial, 1 30.7 TNNT2 SCN5A RYR2 DSP
22 pulmonary embolism 30.6 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
23 endocarditis 30.6 TNNI3 PIK3C2A CRP
24 hypoaldosteronism 30.5 REN ACE
25 acute myocarditis 30.5 TNNT2 TNNI3 NPPB CRP ACE
26 cardiac arrhythmia 30.5 SCN5A RYR2 PKP2 DSP
27 hypertensive heart disease 30.4 REN NR3C2 NPPB ACE
28 atrial heart septal defect 30.4 TNNT2 TNNI3 SCN5A NPPB CRP ACE
29 cardiac conduction defect 30.4 SCN5A RYR2 LMNA DSP DSG2
30 heart valve disease 30.2 TNNI3 REN NR3C2 NPPB CRP ACE
31 atrial fibrillation 30.2 SCN5A RYR2 NR3C2 NPPB LMNA CRP
32 tricuspid valve insufficiency 30.1 TNNI3 REN NPPB CRP ACE
33 aortic valve insufficiency 30.1 TNNI3 REN NPPB CRP ACE
34 hypokalemia 30.0 REN NR3C2 ACE
35 diastolic heart failure 30.0 TNNI3 REN NPPB ACE
36 mitral valve insufficiency 30.0 TNNT2 TNNI3 REN PIK3C2A NR3C2 NPPB
37 patent ductus arteriosus 1 29.9 REN NPPB CRP ACE
38 end stage renal disease 29.9 REN NPPB CRP ACE
39 aortic valve disease 2 29.8 TNNT2 TNNI3 REN NPPB CRP ACE
40 pulmonary edema 29.8 TNNT2 TNNI3 REN PIK3C2A NPPB CRP
41 mitral valve disease 29.8 TNNI3 REN NPPB CRP ACE
42 respiratory failure 29.8 REN PIK3C2A NPPB CRP ACE
43 congestive heart failure 29.8 TNNT2 TNNI3 SCN5A RYR2 REN PIK3C2A
44 atrial standstill 1 29.7 TNNT2 TNNI3 TMEM43 SCN5A RYR2 PKP2
45 lateral myocardial infarction 29.6 TNNI3 SCN5A PIK3C2A NR3C2 ITGA2B ACE
46 chronic kidney disease 29.6 TNNT2 TNNI3 REN NR3C2 NPPB CRP
47 coronary artery vasospasm 29.6 TNNI3 REN PIK3C2A CRP ACE
48 vascular disease 29.5 REN NPPB ITGA2B CRP ACE
49 myopathy 29.4 TNNT2 TNNT1 TNNI3 TMEM43 RYR2 PIK3C2A
50 cardiac tamponade 29.4 TNNI3 REN PIK3C2A NPPB CRP ACE

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock
Sources

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

About this section

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ACE CRP DSC2 DSG2 DSP ITGA2B
2 mortality/aging MP:0010768 9.8 ACE DSG2 DSP ITGA2B LMNA NR3C2
3 muscle MP:0005369 9.36 DSG2 DSP LMNA NR3C2 PKP2 REN
Sources

Drugs & Therapeutics for Left Bundle Branch Hemiblock

About this section

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
3
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
4
Eplerenone Approved Phase 4 107724-20-9 150310 443872
5
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
6
Ramipril Approved Phase 4 87333-19-5 5362129
7
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
8
Enalaprilat Approved Phase 4 76420-72-9 6917719
9
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
10
Bisoprolol Approved Phase 4 66722-44-9 2405
11
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
12
Captopril Approved Phase 4 62571-86-2 44093
13
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
14
Candesartan Experimental Phase 4 139481-59-7 2541
15 Adrenergic beta-Antagonists Phase 4
16 Angiotensin-Converting Enzyme Inhibitors Phase 4
17 Adrenergic Antagonists Phase 4
18 Mineralocorticoids Phase 4
19 Angiotensin Receptor Antagonists Phase 4
20 Adrenergic Agents Phase 4
21 Neurotransmitter Agents Phase 4
22 Mineralocorticoid Receptor Antagonists Phase 4
23
tannic acid Approved Phase 1, Phase 2 1401-55-4
24
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
25 Vasodilator Agents Phase 1, Phase 2
26 Pharmaceutical Solutions Phase 1, Phase 2
27 Vasoconstrictor Agents Phase 1, Phase 2
28 Calcium, Dietary Phase 1, Phase 2
29
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Effect of Cardiac Resynchronization Therapy on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
3 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding Patients to Cardiac Resynchronization Therapy: the STOP-CRT Trial Completed NCT02200822 Phase 4 beta blockers;RAAS blockers
4 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
5 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
6 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
7 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
8 Direct HIS-pacing as an Alternative to Biventricular Pacing in Symptomatic Heart Failure Patients With Severely Reduced LVEF and a True Left Bundle Branch Block Completed NCT03614169
9 AV Optimisation Delivered With Direct His Bundle Pacing, in Patients With Heart Failure, Long PR Without Left Bundle Branch Block: Randomised Multi-centre Clinical Outcome Study. Completed NCT02671903
10 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
11 Direct HIS/LBB Pacing as an Alternative to Biventricular Pacing in Patients With Symptomatic Heart Failure Despite Optimal Medical Treatment and an ECG With a Typical Left Bundle Branch Block Pattern. Recruiting NCT04409119
12 Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following Transcatheter Aortic Valve Replacement. The PROMOTE Study Recruiting NCT04139616
13 Prediction of Heart-failure and Mortality by Echocardiographic Parameters and Machine Learning in Individuals With Left Bundle Branch Block Recruiting NCT04293471
14 Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI) Recruiting NCT03303612
15 Non-invasive Mapping Using Ultra-high Frequency Electrocardiography Recruiting NCT04537455
16 Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block Recruiting NCT03803995
17 Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement Recruiting NCT04128384
18 Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study Recruiting NCT02153307
19 Morphological and Functional Changes, Risk Stratification and Prognosis of Patients With Compete Left Bundle Branch Block Recruiting NCT03096678
20 AdaptResponse Clinical Trial Active, not recruiting NCT02205359
21 Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block: an Observational and Prospective Study. Not yet recruiting NCT04328649
22 Implementation of a Protocol Utilizing Adaptive CRT in a Normal AV Conduction, CRT Non-Response Population at Generator Replacement Terminated NCT03305393
23 Correlation of Clinical Outcomes With ECG Findings in Patients With Left Bundle Branch Block Being Evaluated for Acute Coronary Syndrome - a Prospective Cohort Study Terminated NCT02283619

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Sources

Genetic Tests for Left Bundle Branch Hemiblock

About this section
Sources

Anatomical Context for Left Bundle Branch Hemiblock

About this section

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

40
Heart, Kidney, Skin, Skeletal Muscle, Lung, Atrioventricular Node, Brain
Sources

Publications for Left Bundle Branch Hemiblock

About this section

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 4723)
# Title Authors PMID Year
1
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 54 61
19169971 2008
2
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 61 54
17710992 2007
3
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 54 61
11399338 2001
4
Risk Factors for Postoperative Pacemaker Implantation After Rapid Deployment Aortic Valve Replacement: Results from the RADAR Registry. 61
33665760 2021
5
Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension. 61
33183070 2021
6
Lung Perfusion Scintigraphy in Pulmonary Vein Occlusion After Radiofrequency Ablation. 61
33492855 2021
7
Impact of QRS morphology on response to conduction system pacing after atrioventricular junction ablation. 61
33395736 2021
8
Electrocardiographic features and their echocardiographic correlates in peripartum cardiomyopathy: results from the ESC EORP PPCM registry. 61
33453082 2021
9
Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block. 61
33789682 2021
10
Impact of Baseline Right Bundle Branch Block on Outcomes After Pulmonary Vein Isolation in Patients With Atrial Fibrillation. 61
33385350 2021
11
Exploring the cause of conduction delays in patients with repaired Tetralogy of Fallot. 61
33751080 2021
12
Clinical factors associated with the intraventricular conduction disturbances in Swiss middle-aged adults: The CoLaus|PsyCoLaus study. 61
33309760 2021
13
The Footprints of Pacing Lead Position Using the 12-Lead Electrocardiograph. 61
33162365 2021
14
Predictors of pacemaker implantation after transcatheter aortic valve implantation according to kind of prosthesis and risk profile: a systematic review and contemporary meta-analysis. 61
33289527 2021
15
[Localization of ventricular premature contractions by 12-lead ECG]. 61
33533995 2021
16
Automated detection of arrhythmia from electrocardiogram signal based on new convolutional encoded features with bidirectional long short-term memory network classifier. 61
33405209 2021
17
The importance of the longest R-R interval on 24-hour electrocardiography for mortality prediction in patients with atrial fibrillation. 61
33599460 2021
18
Hiatal hernia as a rare cause of cardiac complications - case based review of the literature. 61
33775064 2021
19
Refractory heart failure with LBBB - Pause before CRT. 61
33775801 2021
20
Catheter ablation of short-coupled variant of torsade de pointes. 61
33770204 2021
21
En kvinne i 50-årene med venstre grenblokk og tilbakevendende arytmier. 61
33754666 2021
22
Cardiac resynchronization therapy with or without defibrillation: a long-standing debate. 61
33758120 2021
23
Five cases of complete atrioventricular block induced by bending forward: unusual but not unique. 61
33693701 2021
24
Intraprocedural dynamics of cardiac conduction during transcatheter aortic valve implantation: Assessment by simultaneous electrophysiological testing. 61
33250391 2021
25
Cardiac contractility modulation for patient with refractory heart failure: an updated evidence-based review. 61
32974722 2021
26
Takotsubo syndrome and pheochromocytoma: an insidious combination. 61
33691391 2021
27
Phrenic nerve stimulation, a rare complication of pacemaker: A case report. 61
33725981 2021
28
Prognostic impact of left ventricular mass regression after transcatheter aortic valve replacement in patients with left ventricular hypertrophy. 61
33781852 2021
29
Cardiac Resynchronization Therapy response assessment with electromechanical activation mapping within 24 hours of device implantation - a pilot study. 61
33675941 2021
30
[Cardiac contractility modulation: a treatment option for patients with refractory heart failure]. 61
33687374 2021
31
Feasibility and safety of both His bundle pacing and left bundle branch area pacing in atrial fibrillation patients: intermediate term follow-up. 61
33723691 2021
32
Transient left bundle branch block after posture change to the prone position during general anesthesia: A case report. 61
33726011 2021
33
Left bundle branch block without a typical contraction pattern is associated with increased risk of ventricular arrhythmias in cardiac resynchronization therapy patients. 61
33755881 2021
34
A young woman with alternating right and left bundle branch block tachycardias: What is the mechanism? 61
33501712 2021
35
CMR in heart failure patients with left bundle branch block: pathophysiology before tissue characterization for better selection of candidates for resynchronisation therapy. 61
33745097 2021
36
Myocardial blood flow imaging in patients with a left bundle branch block or ventricular-paced rhythm: "And therein, as the Bard would tell us, lies the rub". 61
33754301 2021
37
Risk factors for ventricular tachyarrhythmic events in patients without left bundle branch block who receive cardiac resynchronization therapy. 61
33772947 2021
38
Transient complete left bundle branch block during left fascicular ventricular tachycardia. 61
33734358 2021
39
Natural history and clinical significance of isolated complete left bundle branch block without associated structural heart disease. 61
33690131 2021
40
Diagnostic Cardiovascular Magnetic Resonance Imaging Criteria in Noncompaction Cardiomyopathy and the Yield of Genetic Testing. 61
32445794 2021
41
Painful Left Bundle Branch Block Syndrome Complicated by Iron-Overload Cardiomyopathy. 61
33746171 2021
42
Evolution of high-grade atrioventricular conduction disorders after transcatheter aortic valve implantation in patients who underwent implantation of a pacemaker with specific mode-that minimizes ventricular pacing-activated. 61
33625762 2021
43
His-Purkinje system longitudinal dissociation: From bench to bedside. A case of output-dependent fascicular capture. 61
33625765 2021
44
Electrocardiographic Strain Pattern Is a Major Determinant of Rehospitalization for Heart Failure After Transcatheter Aortic Valve Replacement. 61
33459031 2021
45
Are all left bundle branch blocks the same? Myocardial mechanical implications by cardiovascular magnetic resonance. 61
32941866 2021
46
Left atrial strain as a pre-operative prognostic marker for patients with severe mitral regurgitation. 61
32920069 2021
47
Modified annular suturing technique for minimizing postoperative pacemaker use after surgical aortic valve replacement. 61
32725475 2021
48
Prognostic effects of longitudinal changes in left ventricular ejection fraction with cardiac resynchronization therapy. 61
33314797 2021
49
Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study. 61
33426907 2021
50
Effect of a restrictive pacemaker implantation strategy on mortality after transcatheter aortic valve implantation. 61
33372688 2021
Sources

Variations for Left Bundle Branch Hemiblock

About this section
Sources

Expression for Left Bundle Branch Hemiblock

About this section
Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.
Sources

Pathways for Left Bundle Branch Hemiblock

About this section

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Cardiac conduction 65
Show member pathways
 12.56 TNNT2 TNNT1 TNNI3 SCN5A RYR2
2
Cytoskeletal Signaling 4
12.28 TNNT2 TNNI3 LMNA ITGA2B
3
Keratinization 65
Show member pathways
 12.23 PKP2 DSP DSG2 DSC2
4
cGMP-PKG signaling pathway 36
Show member pathways
 12.16 TNNT2 TNNI3 SCN5A RYR2 NPPB
5
Dilated cardiomyopathy 36
Show member pathways
 11.7 TNNT2 TNNI3 RYR2 LMNA ITGA2B ACE
6
Cardiac muscle contraction 36
11.57 TNNT2 TNNI3 RYR2
7
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 60
Show member pathways
 11.48 REN NR3C2 ACE
8
Striated Muscle Contraction 1 65
11.4 TNNT2 TNNT1 TNNI3
9
Arrhythmogenic right ventricular cardiomyopathy 36 1
11.35 RYR2 PKP2 LMNA ITGA2B DSP DSG2
10
Cardiac Progenitor Differentiation 1
11.22 TNNT2 TNNI3 SCN5A
11
Antiarrhythmic Pathway, Pharmacodynamics 60
11.2 SCN5A RYR2 LMNA DSP
Sources

GO Terms for Left Bundle Branch Hemiblock

About this section

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.67 PKP2 DSP DSG2 DSC2
2 sarcomere GO:0030017 9.58 TNNT2 TNNI3 RYR2
3 cornified envelope GO:0001533 9.46 PKP2 DSP DSG2 DSC2
4 cardiac myofibril GO:0097512 9.43 TNNT2 TNNI3
5 troponin complex GO:0005861 9.43 TNNT2 TNNT1 TNNI3
6 cardiac Troponin complex GO:1990584 9.32 TNNT2 TNNI3
7 desmosome GO:0030057 9.26 PKP2 DSP DSG2 DSC2
8 intercalated disc GO:0014704 9.02 SCN5A PKP2 DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.81 PKP2 DSP DSG2 DSC2
2 cell-cell adhesion GO:0098609 9.8 PKP2 DSP DSG2 DSC2
3 muscle contraction GO:0006936 9.78 TNNT2 TNNT1 TNNI3
4 cornification GO:0070268 9.76 PKP2 DSP DSG2 DSC2
5 regulation of blood pressure GO:0008217 9.71 REN NPPB ACE
6 muscle filament sliding GO:0030049 9.65 TNNT2 TNNT1 TNNI3
7 cardiac muscle contraction GO:0060048 9.62 TNNT2 TNNI3 SCN5A RYR2
8 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.61 TNNT2 TNNI3 PKP2
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.6 SCN5A PKP2
10 heart contraction GO:0060047 9.59 TNNI3 ACE
11 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A PKP2
12 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.58 RYR2 PKP2
13 regulation of muscle contraction GO:0006937 9.58 TNNT2 TNNT1 TNNI3
14 amyloid-beta metabolic process GO:0050435 9.57 REN ACE
15 negative regulation of ATPase activity GO:0032780 9.56 TNNT2 TNNI3
16 angiotensin maturation GO:0002003 9.55 REN ACE
17 regulation of heart rate by cardiac conduction GO:0086091 9.55 SCN5A PKP2 DSP DSG2 DSC2
18 ventricular cardiac muscle cell action potential GO:0086005 9.54 SCN5A RYR2 PKP2
19 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.52 TNNI3 RYR2
20 desmosome organization GO:0002934 9.43 PKP2 DSP DSG2
21 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.26 PKP2 DSP DSG2 DSC2
22 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.02 RYR2 PKP2 DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tropomyosin binding GO:0005523 9.26 TNNT2 TNNT1
2 troponin T binding GO:0031014 9.16 TNNT1 TNNI3
3 troponin C binding GO:0030172 8.96 TNNT2 TNNI3
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.92 PKP2 DSP DSG2 DSC2
Sources

Sources for Left Bundle Branch Hemiblock

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....