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MCID: LFT001
MIFTS: 44

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Left Bundle Branch Hemiblock

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MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 74
Left Bundle Branch Block 12 56 15
Left Bundle-Branch Block 74

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 36 426.2
SNOMED-CT 69 4973001
ICD10 34 I44.60
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Summaries for Left Bundle Branch Hemiblock

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MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to atrioventricular block and acute myocardial infarction. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Notch-mediated HES/HEY network and Cardiac Progenitor Differentiation. The drugs Captopril and Bisoprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and mortality/aging

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Related Diseases for Left Bundle Branch Hemiblock

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Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 32.2 NPPB SCN5A
2 acute myocardial infarction 31.6 ACE NPPB TNNI3
3 arteries, anomalies of 31.5 ACE NPPB TNNI3
4 coronary artery anomaly 31.5 ACE NPPB TNNI3
5 third-degree atrioventricular block 31.5 NPPB SCN5A
6 inferior myocardial infarction 31.3 NPPB SULT1E1
7 atrial fibrillation 31.1 ACE NPPB SCN5A
8 ischemic heart disease 30.7 ACE NPPB
9 mitral valve insufficiency 30.7 ACE NPPB SULT1E1
10 coronary stenosis 30.7 ACE NPPB TNNI3
11 syncope 30.7 NPPB SCN5A
12 systolic heart failure 30.6 ACE NPPB
13 anterolateral myocardial infarction 30.6 ACE NPPB SULT1E1
14 atrial standstill 1 30.5 ACE NPPB PKP2 SCN5A TNNI3
15 angina pectoris 30.4 ACE NPPB
16 hypertrophic cardiomyopathy 30.3 ACE SCN5A TNNI3
17 cardiac arrest 30.3 ACE NPPB SCN5A
18 aortic valve insufficiency 30.1 ACE NOTCH1 NPPB
19 dilated cardiomyopathy 30.1 ACE NPPB PKP2 SCN5A TNNI3 TWIST1
20 long qt syndrome 30.1 ALG10B PKP2 SCN5A
21 heart valve disease 30.0 ACE NPPB
22 heart disease 29.8 ACE NOTCH1 NPPB PKP2 SCN5A TNNI3
23 progressive familial heart block, type ia 11.6
24 arrhythmogenic right ventricular dysplasia, familial, 1 11.4
25 first-degree atrioventricular block 11.1
26 myocardial infarction 11.1
27 second-degree atrioventricular block 11.1
28 rere-related disorders 11.0
29 ischemia 10.7
30 congestive heart failure 10.6
31 progressive familial heart block, type ib 10.5
32 right bundle branch block 10.5
33 wolff-parkinson-white syndrome 10.3
34 diabetes mellitus 10.3
35 ventricular septal defect 10.3
36 myocarditis 10.3
37 syndrome of inappropriate antidiuretic hormone 10.3 ACE NPPB
38 idiopathic edema 10.3 ACE NPPB
39 diastolic heart failure 10.3 ACE NPPB
40 bidirectional tachycardia 10.3
41 toxic myocarditis 10.3 NPPB TNNI3
42 renal hypertension 10.2 ACE NPPB
43 pericardium disease 10.2 SULT1E1 TNNI3
44 muscle hypertrophy 10.2
45 left ventricular noncompaction 10.2
46 pulmonary edema 10.2
47 aortitis 10.2
48 pulmonary embolism 10.2
49 dextrocardia 10.2
50 broken heart syndrome 10.2

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 22)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Myocardial Ischemia
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock
Sources

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

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MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACE NOTCH1 PKP2 PTS SCN5A SULT1E1
2 mortality/aging MP:0010768 9.61 ACE IVD NOTCH1 PKP2 PTS SCN5A
3 muscle MP:0005369 9.1 NOTCH1 PKP2 PTS SCN5A TNNI3 TWIST1
Sources

Drugs & Therapeutics for Left Bundle Branch Hemiblock

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Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 200)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 4 62571-86-2 44093
2
Bisoprolol Approved Phase 4 66722-44-9 2405
3
Enalaprilat Approved Phase 4 76420-72-9 6917719
4
Ramipril Approved Phase 4 87333-19-5 5362129
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
7
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
8
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
9
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
10
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
11
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
12
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
15
Chromium Approved Phase 4,Phase 3,Not Applicable 7440-47-3 27668
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
17
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
18
Sirolimus Approved, Investigational Phase 4,Phase 3,Not Applicable 53123-88-9 46835353 5284616 6436030
19
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
20
Ticagrelor Approved Phase 4 274693-27-5 9871419
21
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
22
Everolimus Approved Phase 4,Phase 3,Not Applicable 159351-69-6 70789204 6442177
23
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
24
Dopamine Approved Phase 4,Phase 3 62-31-7, 51-61-6 681
25
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
26
Lithium carbonate Approved Phase 4 554-13-2
27
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
28
Iodine Approved, Investigational Phase 4 7553-56-2 807
29
Povidone Approved Phase 4 9003-39-8
30
Povidone-iodine Approved Phase 4 25655-41-8
31
Amlodipine Approved Phase 4 88150-42-9 2162
32
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
33
Calcium Approved, Nutraceutical Phase 4,Phase 1,Phase 2 7440-70-2 271
34
Candesartan Experimental Phase 4 139481-59-7 2541
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
36 Mineralocorticoids Phase 4
37 diuretics Phase 4
38 Adrenergic Agents Phase 4
39 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
40 Hormone Antagonists Phase 4,Phase 2
41 Diuretics, Potassium Sparing Phase 4
42 Angiotensin Receptor Antagonists Phase 4
43 Natriuretic Agents Phase 4,Phase 3
44 Angiotensin-Converting Enzyme Inhibitors Phase 4
45 Mineralocorticoid Receptor Antagonists Phase 4
46
protease inhibitors Phase 4,Phase 3,Phase 2
47 Adrenergic beta-Antagonists Phase 4
48 Adrenergic Antagonists Phase 4
49 Hormones Phase 4,Phase 3,Phase 2
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) Indication Unknown status NCT01415024 Phase 4
3 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients Unknown status NCT02200822 Phase 4 beta blockers;RAAS blockers
4 Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
5 High-sensitivity Troponin in Cardiac Surgery Completed NCT01913873 Phase 4
6 PROMUS Element Plus US Post-Approval Study Completed NCT01589978 Phase 4 Aspirin;P2Y12 antagonist
7 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4 Lithium or Valproate with placebo (PBO);Lithium or Valproate with Aripiprazole
8 Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation Recruiting NCT01841242 Phase 4 alcoholic povidone iodine;alcoholic chlorhexidine
9 Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes Recruiting NCT03264352 Phase 4 Allisartan Isoproxil;Amlodipine 5mg;Hydrochlorothiazide 25 mg;Allisartan Isoproxil placebo;Amlodipine placebo;Hydrochlorothiazide placebo
10 PCI With AXXESS Biolimus A9 Eluting Bifurcation Stent in Treating Coronary Artery Bifurcation Disease Withdrawn NCT02384629 Phase 4
11 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
12 Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass Completed NCT02025621 Phase 3 Levosimendan;Placebo
13 Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients Completed NCT00550459 Phase 3 Tolvaptan;Placebo
14 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions Completed NCT00823212 Phase 3 Aspirin;Thienopyridine
15 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL) Completed NCT01500434 Phase 3 Aspirin;Thienopyridine
16 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
17 PROMUS Element Japan Small Vessel Trial Completed NCT01080261 Phase 3
18 A Prospective, Multi-center Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Elementâ„¢) Completed NCT00824434 Phase 3
19 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
20 PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK) Completed NCT01510327 Phase 3 Aspirin;Thienopyridine
21 MADIT ASIA Cardiac Resynchronization Trial Terminated NCT01872234 Phase 3
22 Phase III Acute Coronary Syndrome Terminated NCT00831441 Phase 3 Apixaban;Placebo
23 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Unknown status NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
24 Adenosine as an Adjunct to Blood Cardioplegia Unknown status NCT02681913 Phase 2 Adenosine
25 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
26 4 Week Switch Study in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Completed NCT01587924 Phase 2 GSK1278863;rhEPO
27 Study to Investigate the Effects of Orteronel on the QT/QTc Interval in Patients With Metastatic Castration-Resistant Prostate Cancer Completed NCT01549951 Phase 2 Orteronel+Prednisone
28 Apixaban After Anticoagulation-associated Intracerebral Haemorrhage in Patients With Atrial Fibrillation Recruiting NCT02565693 Phase 2 Apixaban;Aspirin;Carbasalate calcium;Clopidogrel;Dipyridamole
29 The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers Completed NCT01999114 Phase 1 Buprenorphine transdermal patch;Naltrexone tablet;Placebos (for TDS and for naltrexone and for moxifloxacin);Moxifloxacin tablet
30 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
31 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
32 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870 Not Applicable
33 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
34 Selective Coronary Vein Sampling in Left Bundle Branch Block and CRT Unknown status NCT02396875 Not Applicable
35 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241 Not Applicable
36 Effect of Bi-ventricular Pacing on Autonomous Nervous System Unknown status NCT00190138 Not Applicable
37 High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery Unknown status NCT02518282
38 HELIox CardiOPlegia Trial During Cardiac surgERy Unknown status NCT02745951 Not Applicable
39 Evaluating Effects of a Left Bundle Branch Block Completed NCT00269659
40 Tailor-CRT: Better Application of Cardiac Resynchronization Therapy Completed NCT02326493 Not Applicable
41 QT Interval in Patients With Pacemaker Dependency Completed NCT01694550
42 Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging Completed NCT01129635 Not Applicable
43 EP-Catheter Guided CS-Lead Implantation Completed NCT01922544
44 The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and Efficiency Completed NCT00704093 Not Applicable
45 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
46 Maximizing CRT Delivery by Using MultipolAr Coronary Sinus Lead FamiLy ACUITY® X4 - RALLY X4 Study Completed NCT02066467
47 Edwards SAPIEN 3 PPI Registry Completed NCT03497611
48 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions in Small Vessels Completed NCT01498692 Not Applicable
49 Electronic Alerts for Stroke Prevention in Patients With Atrial Fibrillation or Atrial Flutter Completed NCT02339493 Not Applicable
50 Leukocytes and Cardiovascular Perioperative Events-2 Completed NCT03105427

Search NIH Clinical Center for Left Bundle Branch Hemiblock

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Genetic Tests for Left Bundle Branch Hemiblock

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Anatomical Context for Left Bundle Branch Hemiblock

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MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

42
Heart, Testes, Lung, Kidney, Bone, Skeletal Muscle, Prostate
Sources

Publications for Left Bundle Branch Hemiblock

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Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 1253)
# Title Authors Year
1
Left ventricular end-systolic contractile entropy can predict cardiac prognosis in patients with complete left bundle branch block. ( 31087265 )
2019
2
Myocardial perfusion artifacts in left bundle branch block: A diagnostic challenge. ( 31049854 )
2019
3
Interesting response of LBBB tachycardia to atrial extra stimulus. ( 31042334 )
2019
4
Left axis deviation in patients with left bundle branch block is a marker of myocardial disease associated with poor response to cardiac resynchronization therapy. ( 31003852 )
2019
5
Re-evaluating the electro-vectorcardiographic criteria for left bundle branch block. ( 30938470 )
2019
6
Defining left bundle branch block-Is this a roadblock to CRT delivery? ( 30928259 )
2019
7
Intermittent Left Bundle Branch Block: What Is the Mechanism? ( 30907486 )
2019
8
A single lead of concordant ST deviation in Left Bundle Branch Block. ( 30902168 )
2019
9
Recurrent transient episodes of left bundle branch block immediately following surgery - A rare phenomenon. ( 30814759 )
2019
10
Influence of Left Bundle Branch Block on the Electrocardiographic Changes Induced by Acute Coronary Artery Occlusion of Distinct Location and Duration. ( 30809155 )
2019
11
True complete left bundle branch block reveals dyssynchrony evaluated by semiconductor single-photon emission computed tomography. ( 30805046 )
2019
12
Automatic diagnosis of strict left bundle branch block using a wavelet-based approach. ( 30802276 )
2019
13
True left bundle branch block and long-term mortality in cardiac resynchronisation therapy patients. ( 30799545 )
2019
14
Differential effect of regadenoson versus dipyridamole on heart rate in patients with left bundle branch block: How does it affect the results of pharmacological nuclear stress testing? ( 30792855 )
2019
15
An interesting case of wide QRS tachycardia with left bundle branch block morphology. ( 30789081 )
2019
16
Predicting response to cardiac resynchronization therapy: use of strict left bundle branch block criteria. ( 30779177 )
2019
17
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar. ( 30772230 )
2019
18
Left bundle branch block after transcatheter aortic valve implantation with Edwards Sapien 3 valve: Influence of the valve depth implantation. ( 30745060 )
2019
19
Low lead one ratio predicts clinical outcomes in left bundle branch block. ( 30740823 )
2019
20
Intracardiac Delineation of Septal Conduction in Left Bundle Branch Block Patterns: Mechanistic Evidence of Left Intra-Hisian Block Circumvented by His Pacing. ( 30704273 )
2019
21
Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy. ( 30661850 )
2019
22
Corrigendum to "Wieslander, et al., Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar" [J Electrocardiol 51(2018) 1071-1076]. ( 30661715 )
2019
23
Cardiac resynchronization therapy reverses severe dyspnea associated with acceleration-dependent left bundle branch block in a patient with structurally normal heart. ( 30614115 )
2019
24
Cardiac resynchronization therapy-induced acute shortening of QRS duration predicts long-term mortality only in patients with left bundle branch block. ( 30403774 )
2019
25
Long-term clinical outcome of persistent left bundle branch block after transfemoral aortic valve implantation. ( 30298700 )
2019
26
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block. ( 30247533 )
2019
27
The prevalence and association of patients with impaired left ventricular ejection fraction and complete left bundle-branch block in Taiwan. ( 30193834 )
2019
28
Multiple myocardial bridges associated with left-ventricular dysfunction, intermittent left bundle branch block, and cardiac memory: A case report. ( 30117721 )
2019
29
Long-term outcomes of His bundle pacing in patients with heart failure with left bundle branch block. ( 30093543 )
2019
30
Guidewire-induced asystole complicating a right internal jugular catheter placement in a patient with pre-existing left bundle branch block: A case report. ( 29984628 )
2019
31
Left bundle branch block: Epidemiology, etiology, anatomic features, electrovectorcardiography, and classification proposal. ( 29932265 )
2019
32
Impact of left bundle branch block (LBBB) in dilated cardiomyopathy (DCM) with intermediate left ventricular systolic dysfunction (LVSD). ( 30594346 )
2019
33
Left bundle branch block in dilated cardiomyopathy with intermediate left ventricular dysfunction: Clinical phenotyping and outcome correlates. ( 30416030 )
2019
34
Transient left bundle branch block and left ventricular dysfunction in a patient with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome. ( 30681047 )
2019
35
Interference dissociation during a baseline complete left bundle-branch block with advanced right bundle-branch block. ( 30974222 )
2019
36
Initial experience with regadenoson stress positron emission tomography in patients with left bundle branch block: Low prevalence of septal defects and high accuracy for obstructive coronary artery disease. ( 30877551 )
2019
37
Postsystolic index for distinguishing coronary artery disease in left bundle branch block. ( 30901114 )
2019
38
Transient left bundle branch block due to massive increase of His bundle pacing threshold associated with acute heart failure in a patient with complete heart block. ( 30891411 )
2019
39
Association of left bundle branch block with new onset abnormal wall motion in treated hypertensive patients with left ventricle hypertrophy: the LIFE Echo Sub-study. ( 30698038 )
2019
40
Feasibility of RA-LV pacing in patients with symptomatic left bundle branch block: a pilot study. ( 30963301 )
2019
41
Myocardial recovery after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy. ( 30267454 )
2019
42
Sex-specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy. ( 30919524 )
2019
43
Left bundle branch block as equivalent of ST-segment elevation myocardial infarction: when yes, when not? ( 30932082 )
2019
44
Gender differences in electro-mechanical characteristics of left bundle branch block: Potential implications for selection and response of cardiac resynchronization therapy. ( 29506744 )
2018
45
Which test for CAD should be used in patients with left bundle branch block? ( 29522390 )
2018
46
Cardiac resynchronization therapy with His bundle pacing as a method of treatment of chronic heart failure in patients with permanent atrial fibrillation and left bundle branch block. ( 29525386 )
2018
47
Incidence of new-onset left bundle branch block and predictors of new permanent pacemaker following transcatheter aortic valve replacement with the Porticoâ„¢ valve. ( 29534170 )
2018
48
Cardiac Hemodynamics Abnormalities Induced by Intermittent Left Bundle-branch Block: A Case Report. ( 29564195 )
2018
49
An interesting case of intra-Hisian Wenkebach with left bundle branch block. ( 29570901 )
2018
50
Contemporary Review of Left Bundle Branch Block in the Failing Heart - Pathogenesis, Prognosis, and Therapy. ( 29097067 )
2018
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Variations for Left Bundle Branch Hemiblock

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Expression for Left Bundle Branch Hemiblock

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Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.
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Pathways for Left Bundle Branch Hemiblock

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Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Notch-mediated HES/HEY network 1
10.64 NOTCH1 TWIST1
2
Cardiac Progenitor Differentiation 1
10.52 NOTCH1 SCN5A TNNI3
Sources

GO Terms for Left Bundle Branch Hemiblock

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Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 8.62 PKP2 SCN5A

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.69 NOTCH1 PKP2 TNNI3
2 negative regulation of osteoblast differentiation GO:0045668 9.55 NOTCH1 TWIST1
3 cardiac muscle contraction GO:0060048 9.54 SCN5A TNNI3
4 positive regulation of epithelial to mesenchymal transition GO:0010718 9.52 NOTCH1 TWIST1
5 regulation of heart rate by cardiac conduction GO:0086091 9.49 PKP2 SCN5A
6 embryonic hindlimb morphogenesis GO:0035116 9.48 NOTCH1 TWIST1
7 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.46 PKP2 TNNI3
8 aortic valve morphogenesis GO:0003180 9.43 NOTCH1 TWIST1
9 ventricular cardiac muscle cell action potential GO:0086005 9.4 PKP2 SCN5A
10 endocardial cushion morphogenesis GO:0003203 9.37 NOTCH1 TWIST1
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.32 PKP2 SCN5A
12 positive regulation of sodium ion transport GO:0010765 9.26 PKP2 SCN5A
13 heart contraction GO:0060047 9.16 ACE TNNI3
14 regulation of blood vessel diameter GO:0097746 8.96 ACE NPPB
15 positive regulation of epithelial cell proliferation GO:0050679 8.8 NOTCH1 SCN5A TWIST1

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 8.8 SCN5A TNNI3 TWIST1
Sources

Sources for Left Bundle Branch Hemiblock

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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