MCID: LFT001
MIFTS: 47

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases
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Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 11 14 71
Left Bundle Branch Block 11 53 14 33
Left Bundle-Branch Block 71

Classifications:



External Ids:

Disease Ontology 11 DOID:10272
ICD9CM 34 426.2
SNOMED-CT 68 266245009
ICD10 31 I44.7
ICD11 33 1553795531
UMLS 71 C0023211 C0155702

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary: Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to progressive familial heart block, type ia and familial isolated arrhythmogenic right ventricular dysplasia. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Cardiac conduction. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and brain, and related phenotypes are muscle and cardiovascular system

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 32.8 SCN5A DSP
2 familial isolated arrhythmogenic right ventricular dysplasia 32.0 TMEM43 SCN5A PKP2 DSP DSC2
3 heart septal defect 31.6 TNNT2 NPPB CRP
4 arteries, anomalies of 31.5 TNNI3 REN CRP ACE
5 second-degree atrioventricular block 31.4 TNNI3 SCN5A LMNA
6 coronary stenosis 31.4 TNNI3 NPPB CRP ACE
7 syncope 31.3 TNNT2 SCN5A RYR2
8 acute myocardial infarction 31.2 TNNT2 TNNI3 REN NR3C2 NPPB CRP
9 angina pectoris 31.2 TNNI3 P2RY12 NPPB CRP ACE
10 inferior myocardial infarction 31.0 TNNT2 TNNT1 TNNI3 NPPB ACE
11 atrioventricular block 31.0 TNNT2 TNNI3 SCN5A RYR2 NPPB LMNA
12 arrhythmogenic right ventricular dysplasia, familial, 1 30.9 TTN TMEM43 RYR2 PKP2 LMNA DSP
13 ventricular fibrillation, paroxysmal familial, 1 30.9 TNNT2 SCN5A RYR2
14 infective endocarditis 30.8 NPPB CRP ACE
15 hypoaldosteronism 30.8 REN ACE
16 hypercholesterolemia, familial, 1 30.8 LMNA CRP ACE
17 first-degree atrioventricular block 30.8 TTN TNNI3 SCN5A NPPB LMNA CRP
18 endocarditis 30.8 TNNT2 TNNI3 CRP
19 wolff-parkinson-white syndrome 30.7 TTN TNNT2 SCN5A NPPB MYBPC3
20 pulmonary embolism 30.6 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
21 pulmonary edema 30.6 TNNT2 TNNI3 REN NPPB CRP ACE
22 rheumatic myocarditis 30.6 TNNT2 TNNI3 CRP
23 hypokalemia 30.6 REN NR3C2 ACE
24 nonobstructive coronary artery disease 30.5 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
25 myocardial infarction 30.5 TNNT2 TNNT1 TNNI3 SCN5A REN P2RY12
26 long covid 30.4 REN CRP ACE
27 aortic valve disease 1 30.4 REN NPPB DSP CRP ACE
28 sick sinus syndrome 30.3 TTN SCN5A RYR2 LMNA
29 peripheral vascular disease 30.3 REN CRP ACE
30 third-degree atrioventricular block 30.3 TTN TNNI3 SCN5A RYR2 REN NPPB
31 right bundle branch block 30.3 TNNT2 TNNI3 SCN5A RYR2 PKP2 NPPB
32 urinary tract infection 30.3 REN NR3C2 CRP ACE
33 atrial fibrillation 30.2 TNNI3 SCN5A RYR2 NR3C2 NPPB LMNA
34 aortic valve disease 2 30.2 TTN TNNT2 TNNI3 REN NPPB MYBPC3
35 coronary artery vasospasm 30.2 TNNT2 TNNT1 TNNI3 REN NPPB CRP
36 cardiac tamponade 30.2 TNNI3 REN NPPB CRP ACE
37 myocarditis 30.1 TTN TNNT2 TNNT1 TNNI3 NPPB LMNA
38 atrial standstill 1 30.1 SCN5A PKP2 NPPB MYBPC3 LMNA DSP
39 cardiac conduction defect 30.1 SCN5A RYR2 MYBPC3 LMNA DSP DSG2
40 congestive heart failure 30.1 TTN TNNT2 TNNI3 SCN5A REN NR3C2
41 cardiac arrest 30.1 TNNT2 TNNI3 SCN5A RYR2 NPPB DSP
42 intermediate coronary syndrome 30.1 TNNT2 TNNT1 TNNI3 REN P2RY12 NPPB
43 tricuspid valve insufficiency 30.0 TNNT2 TNNT1 TNNI3 REN NR3C2 NPPB
44 respiratory failure 30.0 TTN TNNI3 REN NPPB CRP ACE
45 transient cerebral ischemia 30.0 REN P2RY12 NPPB CRP ACE
46 hypertensive heart disease 30.0 TTN TNNT2 TNNI3 REN NR3C2 NPPB
47 ebstein anomaly 29.9 TTN SCN5A NPPB MYBPC3
48 aortic valve insufficiency 29.9 TNNI3 SCAI REN NPPB CRP ACE
49 systolic heart failure 29.9 TTN TNNT2 TNNI3 REN NR3C2 NPPB
50 mitral valve insufficiency 29.8 TTN TNNT2 TNNT1 TNNI3 REN NR3C2

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

GenomeRNAi Phenotypes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACE CRP DSC2 DSG2 DSP LMNA
2 no effect GR00402-S-2 10.18 ACE CRP DSC2 DSG2 LMNA NPPB

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 10.03 DSC2 DSG2 DSP LMNA MYBPC3 NPPB
2 cardiovascular system MP:0005385 9.89 ACE CRP DSC2 DSG2 DSP LMNA
3 mortality/aging MP:0010768 9.5 ACE DSC2 DSG2 DSP LMNA NR3C2

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
2
Tannic acid Approved 1401-55-4 16129878 16129778
3 Adrenergic beta-Antagonists
4 Angiotensin-Converting Enzyme Inhibitors
5 Angiotensin Receptor Antagonists
6 Anti-Arrhythmia Agents

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Resynchronization in Paced Heart Failure Patients With ICD Indication Unknown status NCT01415024 Phase 4
2 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
3 Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure (PhysioSync-HF) Not yet recruiting NCT05572736 Phase 3
4 MADIT ASIA Cardiac Resynchronization Trial (MADIT-ASIA) Terminated NCT01872234 Phase 3
5 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
6 Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy Unknown status NCT03415945
7 Multimodality Assessment of Acute and Long Term Response to Optimised MultiSite Pacing Cardiac Resynchronisation (MSP CRT) Devices Compared to Biventricular (BiV) CRT, in Patients With Heart Failure Unknown status NCT03938090
8 Non-invasive Mapping Using Ultra-high Frequency Electrocardiography Unknown status NCT04537455
9 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
10 Corrected QT Interval in Patients With Pacemaker Dependency (QT-TENDENCY-Study) Completed NCT01694550
11 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
12 Conventional Versus EP-Catheter Guided Implantation of Coronary Sinus Lead in Patients Undergoing Cardiac Resynchronization Therapy Completed NCT01922544
13 Adaptive CRT Effect on Electrical Dyssynchrony Completed NCT02543281
14 Tailor-CRT: Better Application of Cardiac Resynchronization Therapy by Automated and Improved Selection of Location and Timing of Stimulation Completed NCT02326493
15 Direct HIS-pacing as an Alternative to Biventricular Pacing in Symptomatic Heart Failure Patients With Severely Reduced LVEF and a True Left Bundle Branch Block Completed NCT03614169
16 Real-Time Intracardiac Impedograms of Left Ventricular Leads to Locate Sites of Latest Mechanical Delay in Cardiac Resynchronization Therapy Completed NCT01129635
17 AV Optimisation Delivered With Direct His Bundle Pacing, in Patients With Heart Failure, Long PR Without Left Bundle Branch Block: Randomised Multi-centre Clinical Outcome Study. Completed NCT02671903
18 Persistent Left Bundle Branch Block After Rapid-Deployment Aortic Valve Replacement: Incidence, Long-term Prognostic and Predictive Factors Completed NCT04897659
19 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
20 Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement Recruiting NCT04128384
21 Left Bundle Branch Pacing as Initial Therapy in Patients With Non-ischemic Heart Failure and Left Bundle Branch Block (LIT-HF Study) Recruiting NCT05572957 Guideline-Directed Medical Therapy(GDMT)
22 Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI) Recruiting NCT03303612
23 Mid-Q Response Study Recruiting NCT04180696
24 Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block Recruiting NCT03803995
25 Prediction of Heart-failure and Mortality by Echocardiographic Parameters and Machine Learning in Individuals With Left Bundle Branch Block Recruiting NCT04293471
26 Evaluation of Mechanisms and Innovations in Cardiac Resynchronization Therapy Recruiting NCT04221763
27 Acute Hemodynamic Effects of His-bundle Pacing in Bi-Ventricular Pacing Non-responders (The HEPA-His Trial) Recruiting NCT04701112
28 Registro Osservazionale Dei Pazienti Con Blocco Della Branca Sinistra Recruiting NCT05283603
29 Pacing for Cardiac Resynchronisation Using the Intrinsic Conduction System to Maintain Physiologic Ventricular Activation Recruiting NCT04416958
30 Direct HIS/LBB Pacing as an Alternative to Biventricular Pacing in Patients With Symptomatic Heart Failure Despite Optimal Medical Treatment and an ECG With a Typical Left Bundle Branch Block Pattern. Recruiting NCT04409119
31 Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization (CSP-SYNC) Recruiting NCT05155865
32 A Non-inferiority Randomized Comparison Between LEFT BUNDLE Branch Area Pacing and Biventricular Pacing for Cardiac Resynchronization Therapy: The LEFT-BUNDLE-CRT Trial Recruiting NCT05434962
33 Morphological and Functional Changes, Risk Stratification and Prognosis of Patients With Compete Left Bundle Branch Block Recruiting NCT03096678
34 Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study Recruiting NCT02153307
35 Investigating Inhomogeneities of Regional Myocardial WORKload and Metabolism in a Cardiac Resynchronisation Therapy Patient Population Active, not recruiting NCT02537782
36 AdaptResponse Clinical Trial Active, not recruiting NCT02205359
37 Characterization of Acute and Long Term Response to Left Ventricle Only Pacing Combined With MultiPoint Pacing and SyncAV Enrolling by invitation NCT03567096
38 Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With/Without Cardiac Resynchronization Therapy Not yet recruiting NCT05564689
39 Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block: an Observational and Prospective Study. Not yet recruiting NCT04328649
40 Effects of Isolated Left Bundle Branch Block on Maximal Functional Capacity Not yet recruiting NCT05643404
41 BIOTRONIK Conduction System Pacing With the Solia Lead Not yet recruiting NCT05251363
42 CRT-DRIVE: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment Not yet recruiting NCT05327062
43 Correlation of Clinical Outcomes With ECG Findings in Patients With Left Bundle Branch Block Being Evaluated for Acute Coronary Syndrome - a Prospective Cohort Study Terminated NCT02283619
44 High Septal Pacing for Cardiac Resynchronization Therapy Acute Research Study Terminated NCT01325480
45 Optimizing Cardiac Resynchronization Therapy With Electrocardiographic Imaging Terminated NCT03492788
46 MIRACLE EF Clinical Study Terminated NCT01735916
47 LV Endocardial CRT for Patients With Intermediate QRS Width Withdrawn NCT03573427

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Anatomical Context for Left Bundle Branch Hemiblock

Organs/tissues related to Left Bundle Branch Hemiblock:

MalaCards : Heart, Atrioventricular Node, Brain, Bone Marrow, Lung, Prostate, Kidney

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 5111)
# Title Authors PMID Year
1
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 53 62
19169971 2008
2
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 53 62
17710992 2007
3
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 53 62
11399338 2001
4
Right Bundle-Branch Block Pattern in Precordial Leads and Left Bundle-Branch Block Pattern With Left Axis Deviation in Frontal Plane Leads-What Does This Mean? 62
36279124 2022
5
Predictors of high-degree atrioventricular block in patients with new-onset left bundle branch block following transcatheter aortic valve replacement. 62
36056221 2022
6
Impact of left bundle branch block in Takotsubo Syndrome. 62
36176307 2022
7
Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. 62
36408352 2022
8
Safety of Right and Left Ventricular Endomyocardial Biopsy in Heart Transplantation and Cardiomyopathy Patients. 62
36456070 2022
9
A new trend to reduce adverse events in patients undergoing transcatheter aortic valve implantation: cusp overlap technique: a cross sectional study. 62
36460902 2022
10
Cardiomyopathy Induced by Artificial Cardiac Pacing: To Whom, When, Why, and How? Insights on Heart Failure Development. 62
36459472 2022
11
Cardiac resynchronization therapy optimization in nonresponders and incomplete responders using electrical dyssynchrony mapping. 62
35940458 2022
12
Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. 62
35776368 2022
13
Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation. 62
35661380 2022
14
Discussion of LBBP synchronization effects in HF patients with LBBB and comparison with BiV-CRT. 62
35286573 2022
15
Syncope in the athlete - Minor changes, major diagnosis! 62
36442584 2022
16
The Association of Interventricular Activation Delay With Clinical Outcomes in Cardiac Resynchronization Therapy. 62
36436813 2022
17
The impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy. 62
36202658 2022
18
Scar imaging in the dyssynchronous left ventricle: Accuracy of myocardial metabolism by positron emission tomography and function by echocardiographic strain. 62
36460211 2022
19
Introduction to hemodynamic forces by echocardiography. 62
36395921 2022
20
Angiographic findings and treatment of coronary sinus spasm during left ventricular lead placement: A case report. 62
36312766 2022
21
Electrocardiographic predictors of echocardiographic response in cardiac resynchronization therapy: Update of an old story. 62
36274327 2022
22
Subtle QRS changes are associated with reduced ejection fraction, diastolic dysfunction, and heart failure development and therapy responsiveness: Applications for artificial intelligence to ECG. 62
35904538 2022
23
Non-specific intraventricular conduction delay or atypical LBBB - How to predict acute coronary occlusion? 62
36202657 2022
24
Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy? 62
34871385 2022
25
Quantitative distance and electrocardiographic parameters for lead-implanted site selection to enhance the success likelihood of left bundle branch pacing. 62
34761309 2022
26
Should cardiac resynchronization therapy be prescribed before optimizing medical therapy in patients with left bundle branch block-induced cardiomyopathy? 62
36427789 2022
27
Clinical and echocardiographic outcomes with new-onset left bundle branch block after SAPIEN-3 transcatheter aortic valve replacement. 62
36378620 2022
28
Clinical and Experimental Evidence for a Strain-Based Classification of Left Bundle Branch Block-Induced Cardiac Remodeling. 62
36330792 2022
29
Left Bundle Branch Block and Cardiac Resynchronization Therapy: Effector or Bystander? 62
36330794 2022
30
Right-sided approach to left bundle branch area pacing combined with atrioventricular node ablation in a patient with persistent left superior vena cava and left bundle branch block: a case report. 62
36335296 2022
31
Defining left bundle branch block according to the new 2021 European Society of Cardiology criteria. 62
35503400 2022
32
Diagnosing STEMI in right then left bundle branch block pattern ventricular escape rhythm (case report). 62
36447462 2022
33
Automatic identification of septal flash phenomenon in patients with complete left bundle branch block. 62
36223684 2022
34
Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure. 62
36306335 2022
35
Electrocardiogram Belt Guidance for Left Ventricular Lead Placement and Biventricular Pacing Optimization. 62
36442824 2022
36
Short-Term Left Ventricular Reverse Remodeling after Transcatheter Aortic Valve Replacement in Children. 62
35618254 2022
37
Early pacemaker insertion after aortic valve replacement with an Edwards Intuity sutureless valve. 62
36127272 2022
38
Long-Term Ventricular Pacing Dependency and Pacemaker Implantation Predictors after Transcatheter Aortic Valve Replacement - A 1-Year Follow-Up. 62
35857943 2022
39
[Features of vectorcardiograms in patients with hypertension complicated by chronic heart failure with reduced left ventricle ejection fraction]. 62
36286757 2022
40
Trans-jugular vein approach for ablation of ventricular premature contractions originating from the tricuspid annulus. 62
36241038 2022
41
Seismocardiography as a tool for assessment of bi-ventricular pacing. 62
36150374 2022
42
Comparison of Outcomes of Transcatheter Aortic Valve Implantation in Patients With Versus Without Mitral Annular Calcium. 62
35909019 2022
43
Permanent His bundle pacing using a Biotronik stylet-driven Lead: feasibility and early outcomes from a single centre. 62
36240016 2022
44
Women are underrepresented in cardiac resynchronization therapy trials. 62
36259727 2022
45
Outcome of transcatheter aortic valve replacement in patients over 85 years of age versus patients aged 85 and younger. 62
35608812 2022
46
Characterization of the right ventricular substrate participating in postinfarction ventricular tachycardia. 62
35276321 2022
47
Role of the electrocardiogram in differentiating genetically determined dilated cardiomyopathy from athlete's heart. 62
35849080 2022
48
Evaluation of Cardiac Mechanical Dyssynchrony in Heart Failure Patients Using Current Echo-Doppler Modalities. 62
36280273 2022
49
Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST-CRT Upgrade trial. 62
35791276 2022
50
Improved Right Ventricular Systolic Function After Cardiac Resynchronization Therapy in Patients With Heart Failure. 62
36228327 2022

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 RYR2 PKP2 LMNA DSP DSG2 DSC2
2
Show member pathways
12.23 TTN TNNT2 TNNT1 TNNI3 SCN5A RYR2
3 12.16 TNNT2 TNNI3 SCAI LMNA
4
Show member pathways
11.64 REN NR3C2 ACE
5 11.22 TNNT2 TNNI3 SCN5A
6 11.2 SCN5A RYR2 LMNA DSP
7
Show member pathways
10.89 TTN TNNT2 TNNT1 TNNI3 MYBPC3

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.97 PKP2 DSP DSG2 DSC2
2 sarcomere GO:0030017 9.87 TNNT2 TNNI3 RYR2 MYBPC3
3 troponin complex GO:0005861 9.73 TNNI3 TNNT1 TNNT2
4 cardiac Troponin complex GO:1990584 9.71 TNNT2 TNNI3
5 cardiac myofibril GO:0097512 9.63 TNNT2 TNNI3 MYBPC3
6 desmosome GO:0030057 9.56 PKP2 DSP DSG2 DSC2
7 intercalated disc GO:0014704 9.32 SCN5A PKP2 DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 10.08 TNNI3 TNNT1 TNNT2 TTN
2 sarcomere organization GO:0045214 9.97 TTN TNNT2 TNNT1
3 regulation of heart rate by cardiac conduction GO:0086091 9.96 SCN5A PKP2 DSP DSG2 DSC2
4 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.92 MYBPC3 PKP2 TNNI3 TNNT2
5 ventricular cardiac muscle cell action potential GO:0086005 9.91 SCN5A RYR2 PKP2
6 desmosome organization GO:0002934 9.85 PKP2 DSP DSG2
7 angiotensin maturation GO:0002003 9.83 REN ACE
8 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.81 TNNI3 RYR2
9 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.76 PKP2 DSP DSG2 DSC2
10 cardiac muscle contraction GO:0060048 9.73 MYBPC3 RYR2 SCN5A TNNI3 TNNT2 TTN
11 regulation of muscle contraction GO:0006937 9.58 TNNT2 TNNT1 TNNI3
12 regulation of system process GO:0044057 9.46 TNNT2 TNNT1
13 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.32 RYR2 PKP2 DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin T binding GO:0031014 9.46 TNNT1 TNNI3
2 troponin C binding GO:0030172 9.26 TNNT2 TNNI3
3 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.23 PKP2 DSP DSG2 DSC2

Sources for Left Bundle Branch Hemiblock

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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