Left Bundle Branch Hemiblock disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to progressive familial heart block, type ia and familial isolated arrhythmogenic right ventricular dysplasia. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Cardiac conduction. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and brain, and related phenotypes are muscle and cardiovascular system

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Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)

#	Related Disease	Score	Top Affiliating Genes
1	progressive familial heart block, type ia	32.8	SCN5A DSP
2	familial isolated arrhythmogenic right ventricular dysplasia	32.0	TMEM43 SCN5A PKP2 DSP DSC2
3	heart septal defect	31.6	TNNT2 NPPB CRP
4	arteries, anomalies of	31.5	TNNI3 REN CRP ACE
5	second-degree atrioventricular block	31.4	TNNI3 SCN5A LMNA
6	coronary stenosis	31.4	TNNI3 NPPB CRP ACE
7	syncope	31.3	TNNT2 SCN5A RYR2
8	acute myocardial infarction	31.2	TNNT2 TNNI3 REN NR3C2 NPPB CRP
9	angina pectoris	31.2	TNNI3 P2RY12 NPPB CRP ACE
10	inferior myocardial infarction	31.0	TNNT2 TNNT1 TNNI3 NPPB ACE
11	atrioventricular block	31.0	TNNT2 TNNI3 SCN5A RYR2 NPPB LMNA
12	arrhythmogenic right ventricular dysplasia, familial, 1	30.9	TTN TMEM43 RYR2 PKP2 LMNA DSP
13	ventricular fibrillation, paroxysmal familial, 1	30.9	TNNT2 SCN5A RYR2
14	infective endocarditis	30.8	NPPB CRP ACE
15	hypoaldosteronism	30.8	REN ACE
16	hypercholesterolemia, familial, 1	30.8	LMNA CRP ACE
17	first-degree atrioventricular block	30.8	TTN TNNI3 SCN5A NPPB LMNA CRP
18	endocarditis	30.8	TNNT2 TNNI3 CRP
19	wolff-parkinson-white syndrome	30.7	TTN TNNT2 SCN5A NPPB MYBPC3
20	pulmonary embolism	30.6	TNNT2 TNNT1 TNNI3 NPPB CRP ACE
21	pulmonary edema	30.6	TNNT2 TNNI3 REN NPPB CRP ACE
22	rheumatic myocarditis	30.6	TNNT2 TNNI3 CRP
23	hypokalemia	30.6	REN NR3C2 ACE
24	nonobstructive coronary artery disease	30.5	TNNT2 TNNT1 TNNI3 NPPB CRP ACE
25	myocardial infarction	30.5	TNNT2 TNNT1 TNNI3 SCN5A REN P2RY12
26	long covid	30.4	REN CRP ACE
27	aortic valve disease 1	30.4	REN NPPB DSP CRP ACE
28	sick sinus syndrome	30.3	TTN SCN5A RYR2 LMNA
29	peripheral vascular disease	30.3	REN CRP ACE
30	third-degree atrioventricular block	30.3	TTN TNNI3 SCN5A RYR2 REN NPPB
31	right bundle branch block	30.3	TNNT2 TNNI3 SCN5A RYR2 PKP2 NPPB
32	urinary tract infection	30.3	REN NR3C2 CRP ACE
33	atrial fibrillation	30.2	TNNI3 SCN5A RYR2 NR3C2 NPPB LMNA
34	aortic valve disease 2	30.2	TTN TNNT2 TNNI3 REN NPPB MYBPC3
35	coronary artery vasospasm	30.2	TNNT2 TNNT1 TNNI3 REN NPPB CRP
36	cardiac tamponade	30.2	TNNI3 REN NPPB CRP ACE
37	myocarditis	30.1	TTN TNNT2 TNNT1 TNNI3 NPPB LMNA
38	atrial standstill 1	30.1	SCN5A PKP2 NPPB MYBPC3 LMNA DSP
39	cardiac conduction defect	30.1	SCN5A RYR2 MYBPC3 LMNA DSP DSG2
40	congestive heart failure	30.1	TTN TNNT2 TNNI3 SCN5A REN NR3C2
41	cardiac arrest	30.1	TNNT2 TNNI3 SCN5A RYR2 NPPB DSP
42	intermediate coronary syndrome	30.1	TNNT2 TNNT1 TNNI3 REN P2RY12 NPPB
43	tricuspid valve insufficiency	30.0	TNNT2 TNNT1 TNNI3 REN NR3C2 NPPB
44	respiratory failure	30.0	TTN TNNI3 REN NPPB CRP ACE
45	transient cerebral ischemia	30.0	REN P2RY12 NPPB CRP ACE
46	hypertensive heart disease	30.0	TTN TNNT2 TNNI3 REN NR3C2 NPPB
47	ebstein anomaly	29.9	TTN SCN5A NPPB MYBPC3
48	aortic valve insufficiency	29.9	TNNI3 SCAI REN NPPB CRP ACE
49	systolic heart failure	29.9	TTN TNNT2 TNNI3 REN NR3C2 NPPB
50	mitral valve insufficiency	29.8	TTN TNNT2 TNNT1 TNNI3 REN NR3C2

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:

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Symptoms & Phenotypes for Left Bundle Branch Hemiblock

GenomeRNAi Phenotypes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	ACE CRP DSC2 DSG2 DSP LMNA
2	no effect	GR00402-S-2	10.18	ACE CRP DSC2 DSG2 LMNA NPPB

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	10.03	DSC2 DSG2 DSP LMNA MYBPC3 NPPB
2	cardiovascular system	MP:0005385	9.89	ACE CRP DSC2 DSG2 DSP LMNA
3	mortality/aging	MP:0010768	9.5	ACE DSC2 DSG2 DSP LMNA NR3C2

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Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

2

Tannic acid

Approved

1401-55-4

16129878 16129778

3

Adrenergic beta-Antagonists

4

Angiotensin-Converting Enzyme Inhibitors

5

Angiotensin Receptor Antagonists

6

Anti-Arrhythmia Agents

Interventional clinical trials:

(show all 47)

#	Name	Status	NCT ID	Phase	Drugs
1	Resynchronization in Paced Heart Failure Patients With ICD Indication	Unknown status	NCT01415024	Phase 4
2	Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm	Unknown status	NCT02482844	Phase 4
3	Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure (PhysioSync-HF)	Not yet recruiting	NCT05572736	Phase 3
4	MADIT ASIA Cardiac Resynchronization Trial (MADIT-ASIA)	Terminated	NCT01872234	Phase 3
5	HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients	Unknown status	NCT02659137
6	Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy	Unknown status	NCT03415945
7	Multimodality Assessment of Acute and Long Term Response to Optimised MultiSite Pacing Cardiac Resynchronisation (MSP CRT) Devices Compared to Biventricular (BiV) CRT, in Patients With Heart Failure	Unknown status	NCT03938090
8	Non-invasive Mapping Using Ultra-high Frequency Electrocardiography	Unknown status	NCT04537455
9	Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block	Unknown status	NCT01494870
10	Corrected QT Interval in Patients With Pacemaker Dependency (QT-TENDENCY-Study)	Completed	NCT01694550
11	Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study.	Completed	NCT01983293
12	Conventional Versus EP-Catheter Guided Implantation of Coronary Sinus Lead in Patients Undergoing Cardiac Resynchronization Therapy	Completed	NCT01922544
13	Adaptive CRT Effect on Electrical Dyssynchrony	Completed	NCT02543281
14	Tailor-CRT: Better Application of Cardiac Resynchronization Therapy by Automated and Improved Selection of Location and Timing of Stimulation	Completed	NCT02326493
15	Direct HIS-pacing as an Alternative to Biventricular Pacing in Symptomatic Heart Failure Patients With Severely Reduced LVEF and a True Left Bundle Branch Block	Completed	NCT03614169
16	Real-Time Intracardiac Impedograms of Left Ventricular Leads to Locate Sites of Latest Mechanical Delay in Cardiac Resynchronization Therapy	Completed	NCT01129635
17	AV Optimisation Delivered With Direct His Bundle Pacing, in Patients With Heart Failure, Long PR Without Left Bundle Branch Block: Randomised Multi-centre Clinical Outcome Study.	Completed	NCT02671903
18	Persistent Left Bundle Branch Block After Rapid-Deployment Aortic Valve Replacement: Incidence, Long-term Prognostic and Predictive Factors	Completed	NCT04897659
19	Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging	Completed	NCT00269659
20	Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement	Recruiting	NCT04128384
21	Left Bundle Branch Pacing as Initial Therapy in Patients With Non-ischemic Heart Failure and Left Bundle Branch Block (LIT-HF Study)	Recruiting	NCT05572957		Guideline-Directed Medical Therapy(GDMT)
22	Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI)	Recruiting	NCT03303612
23	Mid-Q Response Study	Recruiting	NCT04180696
24	Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block	Recruiting	NCT03803995
25	Prediction of Heart-failure and Mortality by Echocardiographic Parameters and Machine Learning in Individuals With Left Bundle Branch Block	Recruiting	NCT04293471
26	Evaluation of Mechanisms and Innovations in Cardiac Resynchronization Therapy	Recruiting	NCT04221763
27	Acute Hemodynamic Effects of His-bundle Pacing in Bi-Ventricular Pacing Non-responders (The HEPA-His Trial)	Recruiting	NCT04701112
28	Registro Osservazionale Dei Pazienti Con Blocco Della Branca Sinistra	Recruiting	NCT05283603
29	Pacing for Cardiac Resynchronisation Using the Intrinsic Conduction System to Maintain Physiologic Ventricular Activation	Recruiting	NCT04416958
30	Direct HIS/LBB Pacing as an Alternative to Biventricular Pacing in Patients With Symptomatic Heart Failure Despite Optimal Medical Treatment and an ECG With a Typical Left Bundle Branch Block Pattern.	Recruiting	NCT04409119
31	Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization (CSP-SYNC)	Recruiting	NCT05155865
32	A Non-inferiority Randomized Comparison Between LEFT BUNDLE Branch Area Pacing and Biventricular Pacing for Cardiac Resynchronization Therapy: The LEFT-BUNDLE-CRT Trial	Recruiting	NCT05434962
33	Morphological and Functional Changes, Risk Stratification and Prognosis of Patients With Compete Left Bundle Branch Block	Recruiting	NCT03096678
34	Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study	Recruiting	NCT02153307
35	Investigating Inhomogeneities of Regional Myocardial WORKload and Metabolism in a Cardiac Resynchronisation Therapy Patient Population	Active, not recruiting	NCT02537782
36	AdaptResponse Clinical Trial	Active, not recruiting	NCT02205359
37	Characterization of Acute and Long Term Response to Left Ventricle Only Pacing Combined With MultiPoint Pacing and SyncAV	Enrolling by invitation	NCT03567096
38	Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With/Without Cardiac Resynchronization Therapy	Not yet recruiting	NCT05564689
39	Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block: an Observational and Prospective Study.	Not yet recruiting	NCT04328649
40	Effects of Isolated Left Bundle Branch Block on Maximal Functional Capacity	Not yet recruiting	NCT05643404
41	BIOTRONIK Conduction System Pacing With the Solia Lead	Not yet recruiting	NCT05251363
42	CRT-DRIVE: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment	Not yet recruiting	NCT05327062
43	Correlation of Clinical Outcomes With ECG Findings in Patients With Left Bundle Branch Block Being Evaluated for Acute Coronary Syndrome - a Prospective Cohort Study	Terminated	NCT02283619
44	High Septal Pacing for Cardiac Resynchronization Therapy Acute Research Study	Terminated	NCT01325480
45	Optimizing Cardiac Resynchronization Therapy With Electrocardiographic Imaging	Terminated	NCT03492788
46	MIRACLE EF Clinical Study	Terminated	NCT01735916
47	LV Endocardial CRT for Patients With Intermediate QRS Width	Withdrawn	NCT03573427

Search NIH Clinical Center for Left Bundle Branch Hemiblock

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Genetic Tests for Left Bundle Branch Hemiblock

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Anatomical Context for Left Bundle Branch Hemiblock

Organs/tissues related to Left Bundle Branch Hemiblock:

MalaCards : Heart, Atrioventricular Node, Brain, Bone Marrow, Lung, Prostate, Kidney

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Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 5111)

#	Title	Authors	PMID	Year
1	Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. ⁵³ ⁶²	Strabuzynska-Migaj E...Cieslinski A	19169971	2008
2	Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. ⁵³ ⁶²	Sunsaneewitayakul B...Songmuang SB	17710992	2007
3	Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. ⁵³ ⁶²	Dudek D...Dubiel JS	11399338	2001
4	Right Bundle-Branch Block Pattern in Precordial Leads and Left Bundle-Branch Block Pattern With Left Axis Deviation in Frontal Plane Leads-What Does This Mean? ⁶²	Scheffer MK...Costa ACM	36279124	2022
5	Predictors of high-degree atrioventricular block in patients with new-onset left bundle branch block following transcatheter aortic valve replacement. ⁶²	Abdulsalam NM...Barton DE	36056221	2022
6	Impact of left bundle branch block in Takotsubo Syndrome. ⁶²	Lopez J...Chait R	36176307	2022
7	Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. ⁶²	Alshaikh LM...Peacock WF	36408352	2022
8	Safety of Right and Left Ventricular Endomyocardial Biopsy in Heart Transplantation and Cardiomyopathy Patients. ⁶²	Bermpeis K...Vanderheyden M	36456070	2022
9	A new trend to reduce adverse events in patients undergoing transcatheter aortic valve implantation: cusp overlap technique: a cross sectional study. ⁶²	Guzel T...Ertas F	36460902	2022
10	Cardiomyopathy Induced by Artificial Cardiac Pacing: To Whom, When, Why, and How? Insights on Heart Failure Development. ⁶²	Ferrari ADL...Danzmann LC	36459472	2022
11	Cardiac resynchronization therapy optimization in nonresponders and incomplete responders using electrical dyssynchrony mapping. ⁶²	Brown CD...Bank AJ	35940458	2022
12	Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. ⁶²	Bazoukis G...Baranchuk A	35776368	2022
13	Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation. ⁶²	Mechulan A...Dieuzaide P	35661380	2022
14	Discussion of LBBP synchronization effects in HF patients with LBBB and comparison with BiV-CRT. ⁶²	Zhang S...Shan Q	35286573	2022
15	Syncope in the athlete - Minor changes, major diagnosis! ⁶²	Oliveira CC...Marques J	36442584	2022
16	The Association of Interventricular Activation Delay With Clinical Outcomes in Cardiac Resynchronization Therapy. ⁶²	Haqqani HM...Gold MR	36436813	2022
17	The impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy. ⁶²	Xenogiannis I...Sharkey SW	36202658	2022
18	Scar imaging in the dyssynchronous left ventricle: Accuracy of myocardial metabolism by positron emission tomography and function by echocardiographic strain. ⁶²	Larsen CK...Smiseth OA	36460211	2022
19	Introduction to hemodynamic forces by echocardiography. ⁶²	Laenens D...Bax JJ	36395921	2022
20	Angiographic findings and treatment of coronary sinus spasm during left ventricular lead placement: A case report. ⁶²	Komaki T...Ogawa M	36312766	2022
21	Electrocardiographic predictors of echocardiographic response in cardiac resynchronization therapy: Update of an old story. ⁶²	Mugnai G...Ribichini FL	36274327	2022
22	Subtle QRS changes are associated with reduced ejection fraction, diastolic dysfunction, and heart failure development and therapy responsiveness: Applications for artificial intelligence to ECG. ⁶²	Garcia-Escobar A...Moreno R	35904538	2022
23	Non-specific intraventricular conduction delay or atypical LBBB - How to predict acute coronary occlusion? ⁶²	Nikus K...Rankinen J	36202657	2022
24	Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy? ⁶²	Wouters PC...Cramer MJ	34871385	2022
25	Quantitative distance and electrocardiographic parameters for lead-implanted site selection to enhance the success likelihood of left bundle branch pacing. ⁶²	Lu W...Zhang S	34761309	2022
26	Should cardiac resynchronization therapy be prescribed before optimizing medical therapy in patients with left bundle branch block-induced cardiomyopathy? ⁶²	Ramos JT	36427789	2022
27	Clinical and echocardiographic outcomes with new-onset left bundle branch block after SAPIEN-3 transcatheter aortic valve replacement. ⁶²	Sammour YM...Kapadia SR	36378620	2022
28	Clinical and Experimental Evidence for a Strain-Based Classification of Left Bundle Branch Block-Induced Cardiac Remodeling. ⁶²	Calle S...Timmermans F	36330792	2022
29	Left Bundle Branch Block and Cardiac Resynchronization Therapy: Effector or Bystander? ⁶²	Soman P...Malhotra S	36330794	2022
30	Right-sided approach to left bundle branch area pacing combined with atrioventricular node ablation in a patient with persistent left superior vena cava and left bundle branch block: a case report. ⁶²	Prolic Kalinsek T...Zizek D	36335296	2022
31	Defining left bundle branch block according to the new 2021 European Society of Cardiology criteria. ⁶²	Calle S...De Pooter J	35503400	2022
32	Diagnosing STEMI in right then left bundle branch block pattern ventricular escape rhythm (case report). ⁶²	Alsagaff MY...Lusida TTE	36447462	2022
33	Automatic identification of septal flash phenomenon in patients with complete left bundle branch block. ⁶²	Qu M...Ma C	36223684	2022
34	Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure. ⁶²	Liang Y...Ge J	36306335	2022
35	Electrocardiogram Belt Guidance for Left Ventricular Lead Placement and Biventricular Pacing Optimization. ⁶²	Rickard J...ECG Belt for CRT Response Study Group	36442824	2022
36	Short-Term Left Ventricular Reverse Remodeling after Transcatheter Aortic Valve Replacement in Children. ⁶²	Barfuss SB...Tani LY	35618254	2022
37	Early pacemaker insertion after aortic valve replacement with an Edwards Intuity sutureless valve. ⁶²	Mechulan A...Prevot S	36127272	2022
38	Long-Term Ventricular Pacing Dependency and Pacemaker Implantation Predictors after Transcatheter Aortic Valve Replacement - A 1-Year Follow-Up. ⁶²	Pinto RA...Macedo F	35857943	2022
39	[Features of vectorcardiograms in patients with hypertension complicated by chronic heart failure with reduced left ventricle ejection fraction]. ⁶²	Sakhnova TA...Saidova MA	36286757	2022
40	Trans-jugular vein approach for ablation of ventricular premature contractions originating from the tricuspid annulus. ⁶²	Fukuzawa K...Hirata KI	36241038	2022
41	Seismocardiography as a tool for assessment of bi-ventricular pacing. ⁶²	Sorensen K...Schmidt SE	36150374	2022
42	Comparison of Outcomes of Transcatheter Aortic Valve Implantation in Patients With Versus Without Mitral Annular Calcium. ⁶²	Lak HM...Kapadia SR	35909019	2022
43	Permanent His bundle pacing using a Biotronik stylet-driven Lead: feasibility and early outcomes from a single centre. ⁶²	Vezi B...Ragadu J	36240016	2022
44	Women are underrepresented in cardiac resynchronization therapy trials. ⁶²	Ahmad J...Dominic P	36259727	2022
45	Outcome of transcatheter aortic valve replacement in patients over 85 years of age versus patients aged 85 and younger. ⁶²	van den Brink FS...Hofma SH	35608812	2022
46	Characterization of the right ventricular substrate participating in postinfarction ventricular tachycardia. ⁶²	Walsh KA...Santangeli P	35276321	2022
47	Role of the electrocardiogram in differentiating genetically determined dilated cardiomyopathy from athlete's heart. ⁶²	Zaffalon D...Finocchiaro G	35849080	2022
48	Evaluation of Cardiac Mechanical Dyssynchrony in Heart Failure Patients Using Current Echo-Doppler Modalities. ⁶²	Hamdy RM...Fereig HM	36280273	2022
49	Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST-CRT Upgrade trial. ⁶²	Merkely B...Kosztin A	35791276	2022
50	Improved Right Ventricular Systolic Function After Cardiac Resynchronization Therapy in Patients With Heart Failure. ⁶²	Sadeghian H...Raeini AG	36228327	2022

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Genes for Left Bundle Branch Hemiblock

Genes related to Left Bundle Branch Hemiblock (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	NPPB	Natriuretic Peptide B	Protein Coding	13.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19169971 11399338 17710992
2	ACE	Angiotensin I Converting Enzyme	Protein Coding	8.24	DISEASES inferred ¹⁴
3	TNNI3	Troponin I3, Cardiac Type	Protein Coding	7.69	DISEASES inferred ¹⁴
4	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	7.29	DISEASES inferred ¹⁴
5	PKP2	Plakophilin 2	Protein Coding	7.28	DISEASES inferred ¹⁴
6	TNNT2	Troponin T2, Cardiac Type	Protein Coding	7.24	DISEASES inferred ¹⁴
7	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	7.09	DISEASES inferred ¹⁴
8	TNNT1	Troponin T1, Slow Skeletal Type	Protein Coding	7.06	DISEASES inferred ¹⁴
9	CRP	C-Reactive Protein	Protein Coding	6.89	DISEASES inferred ¹⁴
10	DSG2	Desmoglein 2	Protein Coding	6.76	DISEASES inferred ¹⁴
11	DSP	Desmoplakin	Protein Coding	6.62	DISEASES inferred ¹⁴
12	TMEM43	Transmembrane Protein 43	Protein Coding	6.58	DISEASES inferred ¹⁴
13	DSC2	Desmocollin 2	Protein Coding	6.54	DISEASES inferred ¹⁴
14	LMNA	Lamin A/C	Protein Coding	6.4	DISEASES inferred ¹⁴
15	P2RY12	Purinergic Receptor P2Y12	Protein Coding	6.37	DISEASES inferred ¹⁴
16	REN	Renin	Protein Coding	6.3	DISEASES inferred ¹⁴
17	TTN	Titin	Protein Coding	6.22	DISEASES inferred ¹⁴
18	RYR2	Ryanodine Receptor 2	Protein Coding	6.16	DISEASES inferred ¹⁴
19	MYBPC3	Myosin Binding Protein C3	Protein Coding	6.1	DISEASES inferred ¹⁴
20	SCAI	Suppressor Of Cancer Cell Invasion	Protein Coding	6.1	DISEASES inferred ¹⁴
21	JUP	Junction Plakoglobin	Protein Coding	6.09	DISEASES inferred ¹⁴

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Variations for Left Bundle Branch Hemiblock

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Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

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Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.4	RYR2 PKP2 LMNA DSP DSG2 DSC2
2	Cardiac conduction ⁶⁶ Show member pathways Classical Kir channels ⁶⁶ Ion homeostasis ⁶⁶ Ion transport by P-type ATPases ⁶⁶ Muscle contraction ⁶⁶ Phase 1 - inactivation of fast Na+ channels ⁶⁶ Phase 2 - plateau phase ⁶⁶ Phase 3 - rapid repolarisation ⁶⁶ Phase 4 - resting membrane potential ⁶⁶ Physiological factors ⁶⁶ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁶ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁶ Tandem pore domain potassium channels ⁶⁶ TWIK related potassium channel (TREK) ⁶⁶ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁶ TWIK-related spinal cord K+ channel (TRESK) ⁶⁶ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁶	12.23	TTN TNNT2 TNNT1 TNNI3 SCN5A RYR2
3	Cytoskeletal Signaling ³	12.16	TNNT2 TNNI3 SCAI LMNA
4	ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE inhibitor pathway ⁷⁴ Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Conversion of angiotensinogen to angiotensin II ⁷⁴ Defective SERPING1 causes hereditary angioedema ⁶⁶ Downregulation of ACE2 by SARS-CoV-2 spike protein ⁷⁴ Kinin-Kallikrein pathway ⁷⁴ Non-classical role of vitamin D ⁷⁴ RAS and bradykinin pathways in COVID-19 ⁷⁴ Renin-angiotensin-aldosterone system (RAAS) ⁷⁴ SARS-CoV-2 and ACE2 receptor: molecular mechanisms ⁷⁴	11.64	REN NR3C2 ACE
5	Cardiac progenitor differentiation ⁷⁴	11.22	TNNT2 TNNI3 SCN5A
6	Antiarrhythmic Pathway, Pharmacodynamics ⁶⁰	11.2	SCN5A RYR2 LMNA DSP
7	Striated muscle contraction pathway ⁷⁴ Show member pathways Striated Muscle Contraction ⁶⁶	10.89	TTN TNNT2 TNNT1 TNNI3 MYBPC3

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GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cornified envelope	GO:0001533	9.97	PKP2 DSP DSG2 DSC2
2	sarcomere	GO:0030017	9.87	TNNT2 TNNI3 RYR2 MYBPC3
3	troponin complex	GO:0005861	9.73	TNNI3 TNNT1 TNNT2
4	cardiac Troponin complex	GO:1990584	9.71	TNNT2 TNNI3
5	cardiac myofibril	GO:0097512	9.63	TNNT2 TNNI3 MYBPC3
6	desmosome	GO:0030057	9.56	PKP2 DSP DSG2 DSC2
7	intercalated disc	GO:0014704	9.32	SCN5A PKP2 DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:0006936	10.08	TNNI3 TNNT1 TNNT2 TTN
2	sarcomere organization	GO:0045214	9.97	TTN TNNT2 TNNT1
3	regulation of heart rate by cardiac conduction	GO:0086091	9.96	SCN5A PKP2 DSP DSG2 DSC2
4	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.92	MYBPC3 PKP2 TNNI3 TNNT2
5	ventricular cardiac muscle cell action potential	GO:0086005	9.91	SCN5A RYR2 PKP2
6	desmosome organization	GO:0002934	9.85	PKP2 DSP DSG2
7	angiotensin maturation	GO:0002003	9.83	REN ACE
8	regulation of cardiac muscle contraction by calcium ion signaling	GO:0010882	9.81	TNNI3 RYR2
9	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO:0086073	9.76	PKP2 DSP DSG2 DSC2
10	cardiac muscle contraction	GO:0060048	9.73	MYBPC3 RYR2 SCN5A TNNI3 TNNT2 TTN
11	regulation of muscle contraction	GO:0006937	9.58	TNNT2 TNNT1 TNNI3
12	regulation of system process	GO:0044057	9.46	TNNT2 TNNT1
13	regulation of ventricular cardiac muscle cell action potential	GO:0098911	9.32	RYR2 PKP2 DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	troponin T binding	GO:0031014	9.46	TNNT1 TNNI3
2	troponin C binding	GO:0030172	9.26	TNNT2 TNNI3
3	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086083	9.23	PKP2 DSP DSG2 DSC2

Sources

Sources for Left Bundle Branch Hemiblock

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LFT001 MIFTS: 47	Left Bundle Branch Hemiblock Categories: Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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