MCID: LFT001
MIFTS: 45

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases

Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 73
Left Bundle Branch Block 12 29 55 15
Left Bundle-Branch Block 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10272
ICD10 33 I44.60
ICD9CM 35 426.2
SNOMED-CT 68 4973001

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to atrioventricular block and first-degree atrioventricular block. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Keratinization and Cardiac Progenitor Differentiation. Affiliated tissues include heart, liver and testes, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 32.0 NPPB SCN5A
2 first-degree atrioventricular block 31.9 KRT74 SCN5A
3 acute myocardial infarction 31.4 ACE NPPB TNNI3
4 arteries, anomalies of 31.4 ACE NPPB TNNI3
5 coronary artery anomaly 31.4 ACE NPPB TNNI3
6 inferior myocardial infarction 31.1 NPPB SULT1E1
7 atrial fibrillation 31.0 ACE NPPB SCN5A
8 mitral valve insufficiency 30.6 ACE NPPB SULT1E1
9 coronary stenosis 30.6 ACE NPPB TNNI3
10 syncope 30.5 NPPB SCN5A
11 ischemic heart disease 30.5 ACE NPPB
12 systolic heart failure 30.5 ACE NPPB
13 aortic valve insufficiency 30.3 ACE NPPB
14 hypertrophic cardiomyopathy 30.2 ACE SCN5A TNNI3
15 anterolateral myocardial infarction 30.2 SULT1E1 NPPB ACE
16 cardiac arrest 30.1 ACE NPPB SCN5A
17 heart disease 30.1 ACE NPPB PKP2 SCN5A TNNI3
18 dilated cardiomyopathy 30.1 TWIST1 TNNI3 SCN5A PKP2 NPPB JUP
19 atrial standstill 1 30.0 TNNI3 SCN5A PKP2 NPPB JUP ACE
20 left ventricular noncompaction 30.0 JUP PKP2 SCN5A
21 arrhythmogenic right ventricular cardiomyopathy 30.0 JUP PKP2 SCN5A
22 brugada syndrome 29.9 JUP PKP2 SCN5A
23 progressive familial heart block, type ia 11.5
24 arrhythmogenic right ventricular dysplasia, familial, 1 11.4
25 myocardial infarction 11.1
26 second-degree atrioventricular block 11.0
27 ischemia 10.7
28 congestive heart failure 10.6
29 progressive familial heart block, type ib 10.4
30 right bundle branch block 10.4
31 ventricular septal defect 10.3
32 myocarditis 10.3
33 diabetes mellitus 10.3
34 bidirectional tachycardia 10.3
35 third-degree atrioventricular block 10.2 NPPB SCN5A
36 syndrome of inappropriate antidiuretic hormone 10.2 ACE NPPB
37 wolff-parkinson-white syndrome 10.2
38 pulmonary edema 10.2
39 aortitis 10.2
40 pulmonary embolism 10.2
41 dextrocardia 10.2
42 hypoaldosteronism 10.2
43 hyporeninemic hypoaldosteronism 10.2
44 idiopathic edema 10.2 ACE NPPB
45 toxic myocarditis 10.2 NPPB TNNI3
46 diastolic heart failure 10.2 ACE NPPB
47 renal hypertension 10.1 ACE NPPB
48 middle lobe syndrome 10.1 JUP KRT74
49 pericardium disease 10.1 SULT1E1 TNNI3
50 angina pectoris 10.1 ACE NPPB

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 22)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Myocardial Ischemia
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACE JUP PKP2 PTS SCN5A SULT1E1
2 mortality/aging MP:0010768 9.61 ACE IVD JUP PKP2 PTS SCN5A
3 muscle MP:0005369 9.1 JUP PKP2 PTS SCN5A TNNI3 TWIST1

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Search Clinical Trials , NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Genetic tests related to Left Bundle Branch Hemiblock:

# Genetic test Affiliating Genes
1 Left Bundle Branch Block 29

Anatomical Context for Left Bundle Branch Hemiblock

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

41
Heart, Liver, Testes, Kidney, Bone, Skeletal Muscle, Lung

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 1018)
# Title Authors Year
1
A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction. ( 29349559 )
2018
2
Pseudo-Wellens' syndrome and intermittent left bundle branch block in acute cholecystitis. ( 29661666 )
2018
3
Left bundle branch block in dilated cardiomyopathy with intermediate left ventricular dysfunction: Clinical phenotyping and outcome correlates. ( 30416030 )
2018
4
Elevated troponin and left bundle branch block in the setting of suspected septicemia and demand ischemia: to treat or not to treat. ( 30090218 )
2018
5
Left bundle branch block in Duchenne muscular dystrophy: Prevalence, genetic relationship and prognosis. ( 29304097 )
2018
6
Lyme carditis with isolated left bundle branch block and myocarditis successfully treated with oral doxycycline. ( 29326870 )
2018
7
Isolated left bundle branch block progressing to complete heart block and asystole: A novel presentation of a desmin mutation. ( 29915714 )
2018
8
Is exercise stress echocardiography useful in patients with suspected obstructive coronary artery disease who have resting left bundle branch block? ( 29574887 )
2018
9
Termination of tachycardia with resolution of left bundle branch block: What is the mechanism? ( 30228972 )
2018
10
Lead I R-wave amplitude to differentiate idiopathic ventricular arrhythmias with left bundle branch block right inferior axis originating from the left versus right ventricular outflow tract. ( 30230106 )
2018
11
Effect of isolated left bundle-branch block on biventricular volumes and ejection fraction: a cardiovascular magnetic resonance assessment. ( 30231875 )
2018
12
Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block. ( 30232686 )
2018
13
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block. ( 30247533 )
2018
14
Prehospital program for primary percutaneous coronary intervention in patients with left bundle-branch block: Equivalent to intervention in patients with ST-segment elevation? ( 30260124 )
2018
15
Rationale and design for ENHANCE CRT: QLV implant strategy for non-left bundle branch block patients. ( 30264456 )
2018
16
Myocardial recovery after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy. ( 30267454 )
2018
17
Long-term clinical outcome of persistent left bundle branch block after transfemoral aortic valve implantation. ( 30298700 )
2018
18
Prognostic Significance of Left Axis Deviation in Acute Heart Failure Patients with Left Bundle branch block: an Analysis from the Korean Acute Heart Failure (KorAHF) Registry. ( 30334387 )
2018
19
Left Axis Deviation in Patients with Acute Heart Failure with Left Bundle Branch Block: Does It Really Matter? ( 30334388 )
2018
20
Mechanism of harm from left bundle branch block. ( 30401603 )
2018
21
Cardiac resynchronization therapy-induced acute shortening of QRS duration predicts long-term mortality only in patients with left bundle branch block. ( 30403774 )
2018
22
Harm from left bundle branch block: We are the tortoise, not the hare. ( 30425016 )
2018
23
Influence of QRS duration and axis on response to cardiac resynchronization therapy in chronic heart failure with reduced left ventricular ejection fraction: A single center study including patients with left bundle branch block. ( 30444259 )
2018
24
A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study. ( 30476054 )
2018
25
Association between T-wave discordance and the development of heart failure in left bundle branch block patients: Results from the Copenhagen ECG study. ( 30476637 )
2018
26
Painful left bundle branch block syndrome treated with his bundle pacing. ( 30497723 )
2018
27
Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar. ( 30497733 )
2018
28
A larger vectorcardiographic QRS area is associated with left bundle branch block and good prognosis in patients with cardiac resynchronization therapy. ( 30497738 )
2018
29
His Resynchronization Versus Biventricular Pacing in Patients With Heart Failure and Left Bundle Branch Block. ( 30545450 )
2018
30
Idiopathic/Iatrogenic Left Bundle Branch Block-Induced Reversible Left Ventricle Dysfunction: JACC State-of-the-Art Review. ( 30545456 )
2018
31
The prognostic benefit of cardiac resynchronization therapy is greater in concordant vs. discordant left bundle branch block in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). ( 28398490 )
2018
32
New or presumed new left bundle branch block in patients with suspected ST-elevation myocardial infarction. ( 29064258 )
2018
33
Association Between Global Longitudinal Strain and Cardiovascular Events in Patients With Left Bundle Branch Block Assessed Using Two-Dimensional Speckle-Tracking Echocardiography. ( 29079044 )
2018
34
Contemporary Review of Left Bundle Branch Block in the Failing Heart - Pathogenesis, Prognosis, and Therapy. ( 29097067 )
2018
35
Patients with left bundle branch block and left axis deviation show a specific left ventricular asynchrony pattern: Implications for left ventricular lead placement during CRT implantation. ( 29174022 )
2018
36
Do we overestimate left ventricular ejection fraction by two-dimensional echocardiography in patients with left bundle branch block? ( 29178366 )
2018
37
Semi-automated QRS score as a predictor of survival in CRT treated patients with strict left bundle branch block. ( 29203081 )
2018
38
Relation between electrical and mechanical dyssynchrony in patients with left bundle branch block: An electro- and vectorcardiographic study. ( 29251398 )
2018
39
Chest Pain in a Patient With a Left Bundle Branch Block. ( 29268984 )
2018
40
Exercise-induced left bundle branch block - A case report with stress-echocardiographic assessment. ( 29290387 )
2018
41
New-onset left bundle branch block-associated idiopathic nonischemic cardiomyopathy and time from diagnosis to cardiac resynchronization therapy: The NEOLITH II study. ( 29314085 )
2018
42
Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block. ( 29348023 )
2018
43
Cardiomyopathy and Left Bundle Branch Block: A Farewell to Drugs? ( 29348024 )
2018
44
Afterload Hypersensitivity in Patients With Left Bundle Branch Block. ( 29361486 )
2018
45
A Patient with Left Bundle Branch Block and Persistent Atrial Fibrillation Treated with Cardiac Catheter Ablation and Pharmacologic Cardiac Resynchronization Therapy without the Use of an Implantable Cardiac Device. ( 29391388 )
2018
46
Left Bundle Branch Block and New Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement: Are They Benign? ( 29413245 )
2018
47
Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls. ( 29423906 )
2018
48
Programming Cardiac Resynchronization Therapy for Electrical Synchrony: Reaching Beyond Left Bundle Branch Block and Left Ventricular Activation Delay. ( 29432133 )
2018
49
Absence of Rapid Propagation through the Purkinje Network as a Potential Cause of Line Block in the Human Heart with Left Bundle Branch Block. ( 29467667 )
2018
50
Gender differences in electro-mechanical characteristics of left bundle branch block: Potential implications for selection and response of cardiac resynchronization therapy. ( 29506744 )
2018

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 JUP KRT74 PKP2
2 10.68 SCN5A TNNI3

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.43 JUP KRT74 PKP2
2 cell-cell junction GO:0005911 9.33 JUP PKP2 SV2A
3 desmosome GO:0030057 8.96 JUP PKP2
4 intercalated disc GO:0014704 8.8 JUP PKP2 SCN5A

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.69 JUP KRT74 PKP2
2 cardiac muscle contraction GO:0060048 9.52 SCN5A TNNI3
3 cornification GO:0070268 9.5 JUP KRT74 PKP2
4 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.49 PKP2 TNNI3
5 ventricular cardiac muscle cell action potential GO:0086005 9.48 PKP2 SCN5A
6 cardiac muscle cell action potential involved in contraction GO:0086002 9.46 PKP2 SCN5A
7 positive regulation of sodium ion transport GO:0010765 9.43 PKP2 SCN5A
8 heart contraction GO:0060047 9.4 ACE TNNI3
9 regulation of blood vessel diameter GO:0097746 9.37 ACE NPPB
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.26 JUP PKP2
11 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.16 JUP PKP2
12 desmosome assembly GO:0002159 8.96 JUP PKP2
13 regulation of heart rate by cardiac conduction GO:0086091 8.8 JUP PKP2 SCN5A

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.46 JUP SCN5A SV2A TNNI3
2 protein domain specific binding GO:0019904 9.43 SCN5A TNNI3 TWIST1
3 alpha-catenin binding GO:0045294 8.96 JUP PKP2
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 JUP PKP2

Sources for Left Bundle Branch Hemiblock

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....