MCID: LFT001
MIFTS: 47

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases

Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 71
Left Bundle Branch Block 12 54 15
Left Bundle-Branch Block 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 34 426.2
SNOMED-CT 67 266245009
ICD10 32 I44.60 I44.7
UMLS 71 C0023211 C0155702

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to progressive familial heart block, type ia and arrhythmogenic right ventricular dysplasia, familial, 1. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Cardiac conduction and Cytoskeletal Signaling. The drugs Eplerenone and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skeletal muscle, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 32.6 SCN5A DSP
2 arrhythmogenic right ventricular dysplasia, familial, 1 31.7 RYR2 PKP2 DSP DSG2 DSC2
3 second-degree atrioventricular block 31.5 TNNI3 SCN5A
4 third-degree atrioventricular block 31.5 SCN5A NPPB ACE
5 right bundle branch block 31.4 TNNI3 SCN5A PKP2 NPPB DSG2 ACE
6 syncope 31.3 TNNT2 SCN5A RYR2
7 arteries, anomalies of 31.2 TNNI3 REN CRP ACE
8 systolic heart failure 31.1 NR3C2 NPPB CRP ACE
9 inferior myocardial infarction 31.1 TNNI3 PIK3C2A NPPB ACE
10 anterolateral myocardial infarction 31.1 NPPB ACE
11 first-degree atrioventricular block 31.1 SCN5A NPPB LMNA CRP ACE
12 wolff-parkinson-white syndrome 31.0 TNNT2 TNNT1 TNNI3 SCN5A NPPB
13 coronary stenosis 31.0 TNNI3 PIK3C2A NPPB CRP ACE
14 anteroseptal myocardial infarction 31.0 PIK3C2A ACE
15 angina pectoris 31.0 TNNI3 PIK3C2A NPPB CRP ACE
16 acute myocardial infarction 30.9 TNNT2 TNNI3 PIK3C2A NPPB ITGA2B CRP
17 infective endocarditis 30.8 TNNT2 TNNI3 CRP
18 atrioventricular block 30.8 TNNI3 SCN5A RYR2 PIK3C2A NPPB LMNA
19 myocarditis 30.7 TNNI3 PIK3C2A NPPB DSP ACE
20 urinary tract infection 30.7 CRP ACE
21 cardiac conduction defect 30.7 SCN5A RYR2 LMNA DSP
22 ventricular fibrillation, paroxysmal familial, 1 30.7 TNNT2 SCN5A RYR2 DSP
23 pulmonary embolism 30.6 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
24 endocarditis 30.6 TNNI3 PIK3C2A CRP
25 hypoaldosteronism 30.5 REN ACE
26 acute myocarditis 30.5 TNNT2 TNNI3 NPPB CRP ACE
27 cardiac arrhythmia 30.5 SCN5A RYR2 PKP2 DSP
28 atrial heart septal defect 30.4 TNNT2 TNNI3 SCN5A NPPB CRP ACE
29 hypertensive heart disease 30.4 REN NR3C2 NPPB ACE
30 heart valve disease 30.2 TNNI3 REN NR3C2 NPPB CRP ACE
31 tricuspid valve insufficiency 30.2 TNNI3 REN NPPB CRP ACE
32 aortic valve insufficiency 30.2 TNNI3 REN NPPB CRP ACE
33 atrial fibrillation 30.1 SCN5A RYR2 NR3C2 NPPB LMNA CRP
34 hypokalemia 30.0 REN NR3C2 ACE
35 diastolic heart failure 30.0 TNNI3 REN NPPB ACE
36 mitral valve insufficiency 30.0 TNNT2 TNNI3 REN PIK3C2A NR3C2 NPPB
37 patent ductus arteriosus 1 29.9 REN NPPB CRP ACE
38 end stage renal disease 29.9 REN NPPB CRP ACE
39 aortic valve disease 2 29.8 TNNT2 TNNI3 REN NPPB CRP ACE
40 pulmonary edema 29.8 TNNT2 TNNI3 REN PIK3C2A NPPB CRP
41 chronic kidney disease 29.8 TNNT2 TNNI3 REN NR3C2 NPPB CRP
42 mitral valve disease 29.8 TNNI3 REN NPPB CRP ACE
43 respiratory failure 29.8 REN PIK3C2A NPPB CRP ACE
44 congestive heart failure 29.7 TNNT2 TNNI3 SCN5A RYR2 REN PIK3C2A
45 atrial standstill 1 29.7 TNNT2 TNNI3 TMEM43 SCN5A RYR2 PKP2
46 lateral myocardial infarction 29.6 TNNI3 SCN5A PIK3C2A NR3C2 ITGA2B ACE
47 coronary artery vasospasm 29.6 TNNI3 REN PIK3C2A CRP ACE
48 vascular disease 29.5 REN NPPB ITGA2B CRP ACE
49 restrictive cardiomyopathy 29.5 TNNT2 TNNT1 TNNI3 NPPB LMNA DSP
50 intermediate coronary syndrome 29.5 TNNT2 TNNT1 TNNI3 PIK3C2A P2RY12 ITGA2B

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ACE CRP DSC2 DSG2 DSP ITGA2B
2 mortality/aging MP:0010768 9.8 ACE DSG2 DSP ITGA2B LMNA NR3C2
3 muscle MP:0005369 9.36 DSG2 DSP LMNA NR3C2 PKP2 REN

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
3
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
4
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
5
Ramipril Approved Phase 4 87333-19-5 5362129
6
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
7
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
8
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
9
Bisoprolol Approved Phase 4 66722-44-9 2405
10
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
11
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
12
Captopril Approved Phase 4 62571-86-2 44093
13
Enalaprilat Approved Phase 4 76420-72-9 6917719
14
Candesartan Experimental Phase 4 139481-59-7 2541
15 Adrenergic Antagonists Phase 4
16 Angiotensin Receptor Antagonists Phase 4
17 Adrenergic beta-Antagonists Phase 4
18 Angiotensin-Converting Enzyme Inhibitors Phase 4
19 Neurotransmitter Agents Phase 4
20 Mineralocorticoid Receptor Antagonists Phase 4
21 Adrenergic Agents Phase 4
22 Mineralocorticoids Phase 4
23
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
24
tannic acid Approved Phase 1, Phase 2 1401-55-4
25 Pharmaceutical Solutions Phase 1, Phase 2
26 Calcium, Dietary Phase 1, Phase 2
27 Vasodilator Agents Phase 1, Phase 2
28 Vasoconstrictor Agents Phase 1, Phase 2
29
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Effect of Cardiac Resynchronization Therapy on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
3 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding Patients to Cardiac Resynchronization Therapy: the STOP-CRT Trial Completed NCT02200822 Phase 4 beta blockers;RAAS blockers
4 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
5 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
6 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
7 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
8 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
9 AV Optimisation Delivered With Direct His Bundle Pacing, in Patients With Heart Failure, Long PR Without Left Bundle Branch Block: Randomised Multi-centre Clinical Outcome Study. Completed NCT02671903
10 Direct HIS-pacing as an Alternative to Biventricular Pacing in Symptomatic Heart Failure Patients With Severely Reduced LVEF and a True Left Bundle Branch Block Completed NCT03614169
11 Direct HIS/LBB Pacing as an Alternative to Biventricular Pacing in Patients With Symptomatic Heart Failure Despite Optimal Medical Treatment and an ECG With a Typical Left Bundle Branch Block Pattern. Recruiting NCT04409119
12 Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following Transcatheter Aortic Valve Replacement. The PROMOTE Study Recruiting NCT04139616
13 Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI) Recruiting NCT03303612
14 Prediction of Heart-failure and Mortality by Echocardiographic Parameters and Machine Learning in Individuals With Left Bundle Branch Block Recruiting NCT04293471
15 Non-invasive Mapping Using Ultra-high Frequency Electrocardiography Recruiting NCT04537455
16 Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block Recruiting NCT03803995
17 Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study Recruiting NCT02153307
18 Morphological and Functional Changes, Risk Stratification and Prognosis of Patients With Compete Left Bundle Branch Block Recruiting NCT03096678
19 Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement Recruiting NCT04128384
20 AdaptResponse Clinical Trial Active, not recruiting NCT02205359
21 Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block: an Observational and Prospective Study. Not yet recruiting NCT04328649
22 Implementation of a Protocol Utilizing Adaptive CRT in a Normal AV Conduction, CRT Non-Response Population at Generator Replacement Terminated NCT03305393
23 Correlation of Clinical Outcomes With ECG Findings in Patients With Left Bundle Branch Block Being Evaluated for Acute Coronary Syndrome - a Prospective Cohort Study Terminated NCT02283619

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Anatomical Context for Left Bundle Branch Hemiblock

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

40
Heart, Brain, Skeletal Muscle, Atrioventricular Node, Kidney, Prostate, Bone Marrow

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 4668)
# Title Authors PMID Year
1
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 61 54
19169971 2008
2
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 61 54
17710992 2007
3
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 61 54
11399338 2001
4
Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension. 61
33183070 2021
5
Cardiac contractility modulation for patient with refractory heart failure: an updated evidence-based review. 61
32974722 2021
6
Clinical factors associated with the intraventricular conduction disturbances in Swiss middle-aged adults: The CoLaus|PsyCoLaus study. 61
33309760 2021
7
Outcomes of Cardiac Resynchronization Therapy in Patients with Chemotherapy-Induced Cardiomyopathy. 61
33592678 2021
8
Periaortic Ventricular Tachycardias in Nonischemic Cardiomyopathy: Substrate and Electrocardiographic Correlations. 61
33417473 2021
9
Risk Factors and Outcomes of Postprocedure Complete Left Bundle Branch Block After Transcatheter Device Closure of Perimembranous Ventricular Septal Defect. 61
33591822 2021
10
Effects of permanent left bundle branch area pacing on QRS duration and short-term cardiac function in pacing-indicated patients with left bundle branch block. 61
33577192 2021
11
Understanding important factors for arrhythmogenicity associated with transcatheter aortic valve implantation including left bundle branch block: Authors' reply. 61
33450000 2021
12
Electrocardiographic predictors of successful resynchronization of left bundle branch block by His bundle pacing. 61
33345379 2021
13
Associations between left bundle branch block with different PR intervals, QRS durations, heart rates and the risk of heart failure: a register-based cohort study using ECG data from the primary care setting. 61
33574021 2021
14
Understanding important factors for arrhythmogenicity associated with transcatheter aortic valve implantation including left bundle branch block. 61
33352583 2021
15
Arrhythmic burden in patients with new-onset persistent left bundle branch block after transcatheter aortic valve replacement: 2-year results of the MARE study. 61
33083813 2021
16
Local electromechanical alterations determine the left ventricle rotational dynamics in CRT-eligible heart failure patients. 61
33547401 2021
17
Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study. 61
33426907 2021
18
Left Bundle Branch Pacing for Cardiac Resynchronization Therapy: Nonrandomized On-Treatment Comparison With His Bundle Pacing and Biventricular Pacing. 61
32387225 2021
19
Effect of a restrictive pacemaker implantation strategy on mortality after transcatheter aortic valve implantation. 61
33372688 2021
20
Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: Results From the International LBBAP Collaborative Study Group. 61
33602393 2021
21
The importance of the longest R-R interval on 24-hour electrocardiography in mortality prediction in patients with atrial fibrillation. 61
33599460 2021
22
Left atrial strain as a pre-operative prognostic marker for patients with severe mitral regurgitation. 61
32920069 2021
23
Modified annular suturing technique for minimizing postoperative pacemaker use after surgical aortic valve replacement. 61
32725475 2021
24
Are all left bundle branch blocks the same? Myocardial mechanical implications by cardiovascular magnetic resonance. 61
32941866 2021
25
Electrocardiographic Strain Pattern Is a Major Determinant of Rehospitalization for Heart Failure After Transcatheter Aortic Valve Replacement. 61
33459031 2021
26
[Localization of ventricular premature contractions by 12-lead ECG]. 61
33533995 2021
27
Partial versus complete left bundle branch block, does it impact the outcomes with cardiac resynchronization therapy? 61
33518194 2021
28
Rapid reversal of heart failure by correcting left bundle branch block induced by transcatheter aortic valve replacement. 61
33205405 2021
29
A young woman with alternating right and left bundle branch block tachycardias: What is the mechanism? 61
33501712 2021
30
Effects of Newly Developed Right Versus Left Bundle Branch Block on the QRS Axis, T-wave Axis and Frontal QRS-T Angle in Patients with a Narrow QRS. 61
32788526 2021
31
Cardiac resynchronisation therapy in patients with left bundle branch block with residual conduction. 61
33212244 2021
32
The use of Smith-modified Sgarbossa criteria to diagnose an extensive anterior acute myocardial infarction in a patient presenting with a left bundle branch block. 61
33359958 2021
33
Calculated decisions: Sgarbossa criteria for myocardial infarction in left bundle branch block. 61
33476508 2021
34
Electrocardiographic features and their echocardiographic correlates in peripartum cardiomyopathy: results from the ESC EORP PPCM registry. 61
33453082 2021
35
Predicting complete heart block after alcohol septal ablation for hypertrophic cardiomyopathy using a risk stratification model and clinical tool. 61
33491861 2021
36
Left bundle-branch block is associated with asimilar dyssynchronous phenotype in heart failure patients with normal and reduced ejection fractions. 61
33098811 2021
37
Systematic Approach to High Implantation of SAPIEN-3 Valve Achieves a Lower Rate of Conduction Abnormalities Including Pacemaker Implantation. 61
33430603 2021
38
Multipoint Pacing with Fusion-optimized Cardiac Resynchronization Therapy: Using It All to Narrow QRS Duration. 61
33520350 2021
39
Cardiac resynchronization therapy and ventricular tachyarrhythmia burden. 61
33440249 2021
40
Impact of QRS morphology on response to conduction system pacing after atrioventricular junction ablation. 61
33395736 2021
41
Comparison of left ventricle mechanical dyssynchrony parameters in ischemic and non-ischemic patients using 13N-NH3 PET/CT. 61
33398791 2021
42
Segment length in cine (SLICE) strain analysis: a practical approach to estimate potential benefit from cardiac resynchronization therapy. 61
33423681 2021
43
Cardiac resynchronization therapy with intraoperative epicardial mapping via minithoracotomy: 10 years' experience. 61
33184900 2021
44
Long-Term Outcomes in Patients With a Left Ejection Fraction ≤15% Undergoing Cardiac Resynchronization Therapy. 61
33478710 2021
45
Stimulation and propagation of activation in conduction tissue: Implications for left bundle branch area pacing. 61
33418128 2021
46
Lung Perfusion Scintigraphy in Pulmonary Vein Occlusion After Radiofrequency Ablation. 61
33492855 2021
47
Paroxysmal Severe Mitral Regurgitation. 61
33413838 2021
48
Pacemaker-mediated tachycardia in a dual-lead CRT-D: What is the mechanism? 61
33058215 2021
49
Cardiac resynchronization therapy in paediatric patients with congenital heart disease: single centre with 10 years of experience. 61
33500007 2021
50
The value of septal rebound stretch analysis for the prediction of volumetric response to cardiac resynchronization therapy. 61
32699908 2021

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 TNNT2 TNNT1 TNNI3 SCN5A RYR2
2 12.28 TNNT2 TNNI3 LMNA ITGA2B
3
Show member pathways
12.23 PKP2 DSP DSG2 DSC2
4
Show member pathways
12.16 TNNT2 TNNI3 SCN5A RYR2 NPPB
5
Show member pathways
11.75 LMNA DSP DSG2
6
Show member pathways
11.7 TNNT2 TNNI3 RYR2 LMNA ITGA2B ACE
7 11.57 TNNT2 TNNI3 RYR2
8
Show member pathways
11.48 REN NR3C2 ACE
9 11.4 TNNT2 TNNT1 TNNI3
10 11.35 RYR2 PKP2 LMNA ITGA2B DSP DSG2
11 11.22 TNNT2 TNNI3 SCN5A
12 11.2 SCN5A RYR2 LMNA DSP

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.67 PKP2 DSP DSG2 DSC2
2 sarcomere GO:0030017 9.58 TNNT2 TNNI3 RYR2
3 cornified envelope GO:0001533 9.46 PKP2 DSP DSG2 DSC2
4 cardiac myofibril GO:0097512 9.43 TNNT2 TNNI3
5 troponin complex GO:0005861 9.43 TNNT2 TNNT1 TNNI3
6 cardiac Troponin complex GO:1990584 9.32 TNNT2 TNNI3
7 desmosome GO:0030057 9.26 PKP2 DSP DSG2 DSC2
8 intercalated disc GO:0014704 9.02 SCN5A PKP2 DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.81 PKP2 DSP DSG2 DSC2
2 cell-cell adhesion GO:0098609 9.8 PKP2 DSP DSG2 DSC2
3 muscle contraction GO:0006936 9.78 TNNT2 TNNT1 TNNI3
4 cornification GO:0070268 9.76 PKP2 DSP DSG2 DSC2
5 regulation of blood pressure GO:0008217 9.71 REN NPPB ACE
6 muscle filament sliding GO:0030049 9.65 TNNT2 TNNT1 TNNI3
7 cardiac muscle contraction GO:0060048 9.62 TNNT2 TNNI3 SCN5A RYR2
8 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.61 TNNT2 TNNI3 PKP2
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.6 SCN5A PKP2
10 heart contraction GO:0060047 9.59 TNNI3 ACE
11 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A PKP2
12 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.58 RYR2 PKP2
13 regulation of muscle contraction GO:0006937 9.58 TNNT2 TNNT1 TNNI3
14 amyloid-beta metabolic process GO:0050435 9.57 REN ACE
15 negative regulation of ATPase activity GO:0032780 9.56 TNNT2 TNNI3
16 angiotensin maturation GO:0002003 9.55 REN ACE
17 regulation of heart rate by cardiac conduction GO:0086091 9.55 SCN5A PKP2 DSP DSG2 DSC2
18 ventricular cardiac muscle cell action potential GO:0086005 9.54 SCN5A RYR2 PKP2
19 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.52 TNNI3 RYR2
20 desmosome organization GO:0002934 9.43 PKP2 DSP DSG2
21 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.26 PKP2 DSP DSG2 DSC2
22 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.02 RYR2 PKP2 DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tropomyosin binding GO:0005523 9.26 TNNT2 TNNT1
2 troponin T binding GO:0031014 9.16 TNNT1 TNNI3
3 troponin C binding GO:0030172 8.96 TNNT2 TNNI3
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.92 PKP2 DSP DSG2 DSC2

Sources for Left Bundle Branch Hemiblock

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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