MCID: LFT001
MIFTS: 47

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases

Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 72
Left Bundle Branch Block 12 55 15
Left Bundle-Branch Block 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 35 426.2
SNOMED-CT 68 4973001
ICD10 33 I44.60 I44.7
UMLS 72 C0023211 C0155702

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to third-degree atrioventricular block and arteries, anomalies of. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiac Progenitor Differentiation. The drugs Carvedilol and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and liver, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 third-degree atrioventricular block 32.6 SCN5A NPPB
2 arteries, anomalies of 31.8 TNNI3 NPPB ACE
3 syncope 31.6 SCN5A NPPB
4 mitral valve insufficiency 31.6 NPPB ACE
5 coronary stenosis 31.4 TNNI3 NPPB ACE
6 systolic heart failure 31.4 NPPB ACE
7 angina pectoris 31.3 NPPB ACE
8 acute myocardial infarction 31.2 TNNT2 TNNI3 NPPB ACE
9 coronary artery anomaly 31.2 TNNT2 TNNI3 NPPB ACE
10 atrial fibrillation 31.2 SCN5A NPPB ACE
11 anterolateral myocardial infarction 31.2 NPPB ACE
12 myocardial infarction 31.1 TNNT2 TNNI3 NPPB ACE
13 cardiac conduction defect 31.1 SCN5A DSP
14 intermediate coronary syndrome 31.0 TNNI3 ACE
15 aortic valve insufficiency 31.0 NPPB ACE
16 diastolic heart failure 30.8 NPPB ACE
17 myocarditis 30.7 TNNI3 NPPB DSP
18 pulmonary embolism 30.7 TNNT2 TNNI3 NPPB
19 hypertensive heart disease 30.7 NPPB ACE
20 long qt syndrome 30.6 SCN5A PKP2 ALG10B
21 arrhythmogenic right ventricular cardiomyopathy 30.5 SCN5A PKP2 DSP
22 ventricular fibrillation, paroxysmal familial, 1 30.4 TNNT2 SCN5A DSP
23 cardiac arrest 29.9 TNNT2 SCN5A NPPB DSP ACE
24 left ventricular noncompaction 29.8 TNNT2 SCN5A PKP2 DSP
25 hypertrophic cardiomyopathy 29.7 TNNT2 TNNI3 SCN5A DSP ACE
26 dilated cardiomyopathy 29.5 TNNT2 TNNI3 SCN5A PKP2 NPPB DSP
27 atrial standstill 1 29.4 TNNT2 TNNI3 SCN5A PKP2 NPPB DSP
28 heart disease 29.0 TNNT2 TNNI3 SCN5A PKP2 NPPB DSP
29 arrhythmogenic right ventricular dysplasia, familial, 1 11.5
30 atrioventricular block 11.4
31 first-degree atrioventricular block 11.2
32 second-degree atrioventricular block 11.2
33 hyperlipoproteinemia, type iii 11.0
34 congestive heart failure 10.8
35 ischemia 10.8
36 heart septal defect 10.7
37 wolff-parkinson-white syndrome 10.6
38 inferior myocardial infarction 10.6
39 syndrome of inappropriate antidiuretic hormone 10.5 NPPB ACE
40 idiopathic edema 10.5 NPPB ACE
41 vasculogenic impotence 10.5 PTS ACE
42 coronary heart disease 1 10.5
43 heart valve disease 10.5
44 congenitally corrected transposition of the great arteries 10.5 TNNT2 NPPB
45 toxic myocarditis 10.5 TNNI3 NPPB
46 pulmonary edema 10.4
47 heart conduction disease 10.3 SCN5A NPPB ACE
48 sick sinus syndrome 10.3
49 ventricular septal defect 10.3
50 broken heart syndrome 10.3

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACE CD1D DSP PKP2 PTS SCN5A
2 mortality/aging MP:0010768 9.61 ACE CD1D DSP PKP2 PTS SCN5A
3 muscle MP:0005369 9.1 DSP PKP2 PTS SCN5A TNNI3 TNNT2

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
3
Ramipril Approved Phase 4 87333-19-5 5362129
4
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
5
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Eplerenone Approved Phase 4 107724-20-9 150310 443872
8
Bisoprolol Approved Phase 4 66722-44-9 2405
9
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
10
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
11
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
12
Captopril Approved Phase 4 62571-86-2 44093
13
Enalaprilat Approved Phase 4 76420-72-9 6917719
14
Abciximab Approved Phase 4 143653-53-6
15
Tirofiban Approved Phase 4 144494-65-5 60947
16
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
17
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
18
Povidone Approved Phase 4 9003-39-8
19
Iodine Approved, Investigational Phase 4 7553-56-2 807
20
Povidone-iodine Approved Phase 4 25655-41-8
21
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
22
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
23
Tenecteplase Approved Phase 4 191588-94-0
24
Candesartan Experimental Phase 4 139481-59-7 2541
25 Adrenergic beta-Antagonists Phase 4
26 Diuretics, Potassium Sparing Phase 4
27 Mineralocorticoid Receptor Antagonists Phase 4
28 diuretics Phase 4
29 Natriuretic Agents Phase 4
30 Mineralocorticoids Phase 4
31 Adrenergic Antagonists Phase 4
32 Angiotensin Receptor Antagonists Phase 4
33 Angiotensin-Converting Enzyme Inhibitors Phase 4
34 Adrenergic alpha-1 Receptor Antagonists Phase 4
35 Adrenergic alpha-Antagonists Phase 4
36 Lipid Regulating Agents Phase 4
37 Hypolipidemic Agents Phase 4
38 Antimetabolites Phase 4
39 Micronutrients Phase 4
40 Chlorhexidine gluconate Phase 4
41 Disinfectants Phase 4
42 Anti-Infective Agents, Local Phase 4
43 Plasma Substitutes Phase 4
44 Nutrients Phase 4
45 Trace Elements Phase 4
46 Dermatologic Agents Phase 4
47 Anti-Infective Agents Phase 4
48 cadexomer iodine Phase 4
49 Blood Substitutes Phase 4
50 Neurotransmitter Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding Patients to Cardiac Resynchronization Therapy: the STOP-CRT Trial Completed NCT02200822 Phase 4 beta blockers;RAAS blockers
3 Effect of Cardiac Resynchronization Therapy on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
4 FATA: Comparison Between Tirofiban and Abciximab in Facilitated Angioplasty With Stent Implantation: Randomized Multicentre Study Completed NCT00383136 Phase 4 tirofiban high-bolus dose regimen;Abciximab
5 Benign Prostatic Hyperplasia and Ischemic Heart DIsease Completed NCT03856242 Phase 4 Tamsulosin Oral Capsule
6 A Randomised Trial on Early Stress Nuclear Scan for Patients Presented to the Emergency Department (ED) With Chest Pain But Non-diagnostic Electrocardiography-Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
7 Early Effect Of Bezafibrate On Fibrinogen Levels, Inflammatory Response And Clinical Impact, In Patients With ST Elevation Acute Myocardial Infarction Completed NCT02291796 Phase 4 Bezafibrate
8 Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation Active, not recruiting NCT01841242 Phase 4 alcoholic povidone iodine;alcoholic chlorhexidine
9 TRIANA: A Randomized Trial to Compare the Efficay and Safety of Thrombolysis With Primary Angioplasty as Initial Reperfusion Therapy in Older Patients (>= 75 Years Old) With Acute Myocardial Infarction Terminated NCT00257309 Phase 4 Tenecteplase + UFH (+ clopidogrel, since 01/97)
10 The Assessment of Cardiac Magnetic Resonance Imaging Guided Left Ventricular Lead Placement During the Implantation of Cardiac Resynchronisation Therapy on Clinical Outcomes in Patients With Chronic Heart Failure Unknown status NCT01417624 Phase 3
11 Prevention of Coronary Artery in STENT Restenosis With the Combined Use of Pioglitazone and Sirolimus-Eluting Coronary Stent Unknown status NCT00376870 Phase 3 Pioglitazone;Placebo
12 Study to Evaluate the Efficacy and Safety of Paclitaxel Eluting Balloon in St Elevation Myocardial Infarction After Bare Metal Stent Insertion Completed NCT01839890 Phase 3
13 CABG Off or On Pump Revascularization Study (CORONARY) Completed NCT00463294 Phase 3
14 Study to Evaluate the Efficacy and Safety of Paclitaxel Eluting Balloon After Bare Metal Stent Implantation Versus Drug-eluting Stent in St Elevation Myocardial Infarction Recruiting NCT03610347 Phase 3
15 The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute ST-segment Elevation Myocardial Infarction (RECONSIDER) Recruiting NCT03371784 Phase 2, Phase 3 Hydrocortisone;Placebo
16 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
17 MADIT ASIA Cardiac Resynchronization Trial (MADIT-ASIA) Terminated NCT01872234 Phase 3
18 Bivalirudin Infusion for Ventricular Infarction Limitation Terminated NCT02565147 Phase 3 Bivalirudin;Heparin
19 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
20 Intracoronary Injection of Melatonin for Patients With ST-elevation Myocardial Infarction: a Placebo Controlled Randomized Study Completed NCT01172171 Phase 2 Melatonin, N-acetyl-5-methoxytryptamine;Isotonic saline, Natrium chloride
21 Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study Completed NCT01006863 Phase 2 Ephedrine;Placebo;Phenylephrine
22 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
23 Phase 1 Study to Assess the Safety of 500mg of Aspirin Added to IV TPA at Standard Doses to Prevent Re-occlusion of Cerebral Vessels After Successful Reperfusion. Withdrawn NCT00417898 Phase 1 Aspirin
24 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
25 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
26 Predictives Factors of Cardiac Resynchronization Therapy: a Multimodal Analysis Using 2D Speckle Tracking Echocardiography Coupled With MIBG Myocardial Scintigraphy and Heart Failure Biomarkers Unknown status NCT02018029
27 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
28 Effect of Bi-ventricular Pacing on Autonomous Nervous System Unknown status NCT00190138
29 Paced Electrocardiogram Requiring Fast Emergent Coronary Therapy (PERFECT) Study Unknown status NCT02765477
30 Relevamiento / Encuesta Nacional de Infarto Agudo de Miocardio Con elevación Del ST Unknown status NCT02458885
31 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
32 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
33 The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and Efficiency Completed NCT00704093
34 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
35 Triple-site Biventricular Stimulation in the Optimization of Cardiac Resynchronization Therapy (CRT) Completed NCT02350842
36 Prognostic Impact of Combined Contrast-Induced Acute Kidney Injury and Hypoxic Liver Injury in Patients With ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Completed NCT02800421
37 Study of High Sensitive Troponin-I Level in End-stage Renal Disease Patients Receiving Hemodialysis Completed NCT02572466
38 Prevalence of Myocardial Injury in Gastrointestinal Surgery Patients - A Multi-center Prospective Cohort Study - POMY Completed NCT02885415
39 Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing. Completed NCT01652248
40 The Unidentified Association of Gated SPECT Abnormality With J Point Elevation Completed NCT03472898
41 Trhombus Aspiration in Hyperglycemic ST-elevation myocardiAl InfarcTIon (STEMI) Patients: 1-year Follow-up of the Prospective Randomised TAHITI Study Completed NCT02817542
42 Impact of Coronary Dye Injection Pressure on Myocardial Reperfusion During the Primary Percutaneous Coronary Intervention. Completed NCT03445364
43 Novel Methods for Arrhythmia Detection: Chest Strap ECG and Wrist Band Photoplethysmography Compared to Holter-device for Atrial Fibrillation Detection Completed NCT03721601
44 Tailor-CRT: Better Application of Cardiac Resynchronization Therapy by Automated and Improved Selection of Location and Timing of Stimulation Completed NCT02326493
45 Identifying High Risk Patients With Syncope Completed NCT00005202
46 Assessing the Capability of Cardiogoniometry (CGM) to Detect Changes in Cardiac Resynchronisation Therapy Device Settings Completed NCT02803879
47 COCHISE Pilot Study: Closed vs Open Cells Stent for High Risk Percutaneous Coronary Interventions in ST Elevation Acute Myocardial Infarction Completed NCT01152138
48 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
49 Multipolar Pacing by Cardiac Resynchronization Therapy With a Defibrillator as Treatment in Type 2 Diabetes Mellitus Failing Heart Patients: Impact on Responders Rate, and Clinical Outcomes. Completed NCT03095196 HF drugs
50 Target Temperature Management 33°C Versus 36°C After Out-of-hospital Cardiac Arrest, a Randomised, Parallel Groups, Assessor Blinded Clinical Trial Completed NCT01020916

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Anatomical Context for Left Bundle Branch Hemiblock

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

41
Heart, Testes, Liver, Brain, Kidney, Prostate, Bone

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 4337)
# Title Authors PMID Year
1
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 9 38
19169971 2008
2
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 9 38
17710992 2007
3
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 9 38
11399338 2001
4
Mitral Annulus Calcium Score. 38
30636515 2019
5
Feasibility of RA-LV pacing in patients with symptomatic left bundle branch block: a pilot study. 38
30963301 2019
6
Editorial commentary: Harm from left bundle branch block: We are the tortoise, not the hare. 38
30425016 2019
7
Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls. 38
29423906 2019
8
Case study of thyrotoxic cardiomyopathy. 38
31434668 2019
9
Trastuzumab-Induced Cardiomyopathy and Intermittent Left Bundle Branch Block. 38
31413780 2019
10
Conduction Abnormalities and Long-Term Mortality Following Septal Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy. 38
31370956 2019
11
Tachycardia-induced cardiomyopathy in a patient with left-sided accessory pathway and left bundle branch block: A case report. 38
31393361 2019
12
Clinical implications of electrocardiographic bundle branch block in primary care. 38
31129608 2019
13
Mechanism of harm from left bundle branch block. 38
30401603 2019
14
Intermittent left bundle branch block: What is the mechanism? 38
30907486 2019
15
Premature atrial extra stimulus on left bundle branch block tachycardia. 38
31111579 2019
16
The effects of cardiac resynchronization therapy on left ventricular and mitral valve geometry and secondary mitral regurgitation in patients with left bundle branch block. 38
31424113 2019
17
Idiopathic Basal Crux Ventricular Arrhythmias with Left Bundle Branch Block and Superior Axis -A Comparison with Inferior-septal Valvular Arrhythmias. 38
31392788 2019
18
Regadenoson myocardial perfusion imaging predicts prognosis in patients with either left bundle branch block or a ventricular paced rhythm. 38
31385224 2019
19
Ischemic ventricular tachycardia from below the posteromedial papillary muscle, a particular entity: Substrate characterization and challenges for catheter ablation. 38
31085181 2019
20
Immediate clinical outcomes of left bundle branch area pacing vs conventional right ventricular pacing. 38
31184785 2019
21
Improvement of abnormal systolic motion of the interventricular septum with cardiac resynchronization therapy. 38
31390077 2019
22
Atrial fibrillation incidence and impact of biventricular pacing on long-term outcome in patients with heart failure treated with cardiac resynchronization therapy. 38
31409276 2019
23
Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample. 38
31317468 2019
24
Prognostic significance of P-wave morphology in patients with coronary artery disease. 38
31310355 2019
25
Smartphone electrocardiograms reveal painful left bundle branch block syndrome and illustrate associated electrophysiological phenomena. 38
31365081 2019
26
Re-evaluating the electro-vectorcardiographic criteria for left bundle branch block. 38
30938470 2019
27
Web Exclusive. Annals Consult Guys - New Left Bundle Branch Block: Should This Block Surgery? 38
31307089 2019
28
Acute myocardial infarction in the setting of left bundle branch block: Chapman's sign. 38
31395406 2019
29
How does new-onset left bundle branch block affect the outcomes of transcatheter aortic valve repair? 38
31172837 2019
30
Severe myocardial ischemia in a patient with diabetes mellitus and left bundle branch block. 38
31309462 2019
31
QT-Interval Assessment in Left Bundle Branch Block: Deciphering Normal Within Abnormal. 38
31292074 2019
32
Determination of the QT Interval in Left Bundle Branch Block: Development of a Novel Formula. 38
31292084 2019
33
Left bundle branch block during antegrade balloon aortic valvuloplasty caused by stiff-wire loop stress. 38
29987652 2019
34
Defining left bundle branch block-Is this a roadblock to CRT delivery? 38
30928259 2019
35
Resolution of new left bundle branch block and ventricular tachycardia with immunosuppressive therapy in a patient with cardiac sarcoidosis. 38
31341784 2019
36
Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy. 38
30661850 2019
37
Sex-specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy. 38
30919524 2019
38
Cardiac conduction abnormalities associated with pacemaker implantation after transcatheter aortic valve replacement. 38
30977144 2019
39
Simulation of action potential propagation based on the ghost structure method. 38
31358816 2019
40
Occurrence of complete heart block associated with acute renal infarction. 38
31353782 2019
41
CRT Optimization: What Is New? What Is Necessary? 38
31342198 2019
42
Interruption of cardiac resynchronization therapy triggered by the automatic right-ventricular pacing threshold test. 38
31152992 2019
43
Unusual manifestation of left ventricular electrical conduction delay on the surface 12-lead electrocardiogram in a patient with prior myocardial infarction. 38
31078105 2019
44
The characteristics of the electrocardiogram and the intracardiac electrogram in left bundle branch pacing. 38
31094058 2019
45
Prognostic utility of electrocardiograms in patients with hypertension older than 65 years. The PAFRES study. 38
31272678 2019
46
Prognostic Implication of Ventricular Conduction Disturbance Pattern in Hospitalized Patients with Acute Heart Failure Syndrome. 38
30891964 2019
47
Do all intra-ventricular conduction defect ECG patterns respond equally to CRT? 38
31332607 2019
48
Fully automated QRS area measurement for predicting response to cardiac resynchronization therapy. 38
31324399 2019
49
A novel risk model for very late return of atrial fibrillation beyond 1 year after cryoballoon ablation: the SCALE-CryoAF score. 38
31327104 2019
50
Cardiac Memory: A Case Report and Review of the Literature. 38
31047746 2019

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.4 TNNT2 TNNI3 ACE
2 10.52 TNNT2 TNNI3 SCN5A

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.54 SV2A PKP2 DSP
2 myofibril GO:0030016 9.4 TNNT2 TNNI3
3 desmosome GO:0030057 9.32 PKP2 DSP
4 troponin complex GO:0005861 9.26 TNNT2 TNNI3
5 cardiac myofibril GO:0097512 9.16 TNNT2 TNNI3
6 intercalated disc GO:0014704 9.13 SCN5A PKP2 DSP
7 cardiac Troponin complex GO:1990584 8.62 TNNT2 TNNI3

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transport GO:0006836 9.56 SV2A CPLX4
2 muscle filament sliding GO:0030049 9.55 TNNT2 TNNI3
3 skeletal muscle contraction GO:0003009 9.54 TNNT2 TNNI3
4 regulation of muscle contraction GO:0006937 9.51 TNNT2 TNNI3
5 ventricular cardiac muscle cell action potential GO:0086005 9.49 SCN5A PKP2
6 positive regulation of sodium ion transport GO:0010765 9.48 SCN5A PKP2
7 cardiac muscle cell action potential involved in contraction GO:0086002 9.46 SCN5A PKP2
8 heart contraction GO:0060047 9.43 TNNI3 ACE
9 regulation of blood vessel diameter GO:0097746 9.4 NPPB ACE
10 negative regulation of ATPase activity GO:0032780 9.37 TNNT2 TNNI3
11 cardiac muscle contraction GO:0060048 9.33 TNNT2 TNNI3 SCN5A
12 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.32 PKP2 DSP
13 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.26 PKP2 DSP
14 posttranscriptional regulation of gene expression GO:0010608 9.22 ACE
15 regulation of heart rate by cardiac conduction GO:0086091 9.13 SCN5A PKP2 DSP
16 ventricular cardiac muscle tissue morphogenesis GO:0055010 8.8 TNNT2 TNNI3 PKP2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.96 PKP2 DSP
2 troponin C binding GO:0030172 8.62 TNNT2 TNNI3

Sources for Left Bundle Branch Hemiblock

3 CDC
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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73 UMLS via Orphanet
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