Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases

Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 71
Left Bundle Branch Block 12 54 15
Left Bundle-Branch Block 71


External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 34 426.2
SNOMED-CT 67 4973001
ICD10 32 I44.60 I44.7
UMLS 71 C0023211 C0155702

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to arrhythmogenic right ventricular dysplasia, familial, 1 and third-degree atrioventricular block. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are cGMP-PKG signaling pathway and Cytoskeletal Signaling. The drugs Metoprolol and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 arrhythmogenic right ventricular dysplasia, familial, 1 33.1 PKP2 DSG2
2 third-degree atrioventricular block 32.4 SCN5A NPPB ACE
3 second-degree atrioventricular block 32.3 TNNI3 SCN5A
4 first-degree atrioventricular block 31.9 SCN5A NPPB LMNA CRP ACE
5 atrioventricular block 31.7 TNNI3 SCN5A PIK3C2A NPPB LMNA ACE
6 inferior myocardial infarction 31.3 TNNI3 PIK3C2A NPPB
7 anterolateral myocardial infarction 31.2 NPPB ACE
8 systolic heart failure 31.2 NR3C2 NPPB CRP ACE
9 ventricular fibrillation, paroxysmal familial, 1 31.2 TNNT2 SCN5A DSP
10 cardiac conduction defect 31.1 SCN5A LMNA DSP
11 wolff-parkinson-white syndrome 31.1 TNNT2 TNNT1 TNNI3 SCN5A NPPB
12 arteries, anomalies of 31.1 TNNI3 REN P2RY12 CRP ACE
13 coronary stenosis 31.0 TNNI3 PIK3C2A NPPB CRP ACE
14 cardiogenic shock 30.9 PIK3C2A NPPB CRP
15 cardiac sarcoidosis 30.9 PKP2 DSP ACE
16 angina pectoris 30.9 TNNI3 PIK3C2A NPPB CRP ACE
17 hypoaldosteronism 30.7 REN ACE
18 anteroseptal myocardial infarction 30.7 PIK3C2A IL4I1
19 coronary artery vasospasm 30.7 TNNI3 CRP ACE
20 myocarditis 30.7 TNNI3 PIK3C2A NPPB DSP ACE
21 infective endocarditis 30.6 TNNT2 TNNI3 CRP
22 pulmonary embolism 30.6 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
23 hypertensive heart disease 30.6 REN NR3C2 NPPB ACE
24 acute myocarditis 30.6 TNNT2 TNNI3 NPPB CRP ACE
25 heart valve disease 30.4 TNNI3 REN NR3C2 NPPB CRP ACE
26 endocarditis 30.3 TNNI3 PIK3C2A CRP
27 tricuspid valve insufficiency 30.3 TNNI3 REN NPPB CRP ACE
28 acute cystitis 30.3 REN CRP ACE
29 diastolic heart failure 30.2 TNNI3 REN NPPB ACE
30 patent ductus arteriosus 1 30.1 REN NPPB CRP ACE
31 atrial standstill 1 30.1 TNNT2 TNNI3 SCN5A PKP2 NPPB LMNA
32 lateral myocardial infarction 30.1 PIK3C2A NACC2 ITGA2B
33 right bundle branch block 30.1 TNNI3 SCN5A PKP2 NPPB NACC2 DSG2
34 atrial heart septal defect 30.1 TNNT2 TNNI3 SCN5A NPPB IL4I1 CRP
35 lipoprotein quantitative trait locus 30.0 TNNT2 TNNI3 SCN5A REN PIK3C2A NPPB
36 acute myocardial infarction 29.9 TNNT2 TNNI3 REN PIK3C2A NR3C2 NPPB
37 aortic valve insufficiency 29.8 TNNI3 REN NPPB IL4I1 CRP ACE
38 hypokalemia 29.8 REN PIK3C2A NR3C2 ACE
39 rare cardiomyopathy 29.8 TNNT2 TNNI3 PKP2 LMNA DSP DSG2
40 aortic valve disease 2 29.8 TNNT2 TNNI3 REN NPPB CRP ACE
41 arrhythmogenic right ventricular cardiomyopathy 29.7 TMEM43 SCN5A PKP2 NPPB LMNA DSP
42 vascular disease 29.7 REN NPPB ITGA2B CRP ACE
43 long qt syndrome 29.7 TMEM43 SCN5A PKP2 LMNA DSP DSG2
44 respiratory failure 29.6 REN PIK3C2A NPPB CRP ACE
45 pulmonary edema 29.6 TNNT2 TNNI3 REN PIK3C2A NR3C2 NPPB
46 mitral valve disease 29.6 TNNI3 REN NPPB IL4I1 CRP ACE
47 mitral valve insufficiency 29.6 TNNT2 TNNI3 REN PIK3C2A NR3C2 NPPB
48 intermediate coronary syndrome 29.5 TNNT2 TNNT1 TNNI3 PIK3C2A P2RY12 ITGA2B
49 tetralogy of fallot 29.5 TNNT2 TNNI3 SCN5A REN NPPB CRP
50 chronic kidney disease 29.5 TNNT2 TNNI3 REN NR3C2 NPPB CRP

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)

Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:

Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

GenomeRNAi Phenotypes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.72 PIK3C2A
2 Decreased viability GR00055-A-2 9.72 PIK3C2A
3 Decreased viability GR00055-A-3 9.72 PIK3C2A
4 Decreased viability GR00221-A-1 9.72 PIK3C2A
5 Decreased viability GR00221-A-2 9.72 PIK3C2A
6 Decreased viability GR00221-A-4 9.72 PIK3C2A
7 Decreased viability GR00240-S-1 9.72 LMNA PIK3C2A
8 Decreased viability GR00249-S 9.72 IL4I1 LMNA PIK3C2A TNNT2
9 Decreased viability GR00342-S-1 9.72 PIK3C2A
10 Decreased viability GR00342-S-2 9.72 PIK3C2A
11 Decreased viability GR00342-S-3 9.72 PIK3C2A
12 Decreased viability GR00381-A-1 9.72 NACC2 TMEM43
13 Decreased viability GR00386-A-1 9.72 ITGA2B LMNA NR3C2 TNNT1
14 Decreased viability GR00402-S-2 9.72 DSP NACC2 P2RY12 SCN5A

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ACE CRP DSC2 DSG2 DSP IL4I1
2 mortality/aging MP:0010768 9.8 ACE DSG2 DSP IL4I1 ITGA2B LMNA
3 muscle MP:0005369 9.32 DSG2 DSP LMNA NR3C2 PKP2 REN

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
Lisinopril Approved, Investigational Phase 4 76547-98-3, 83915-83-7 5362119
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
Nebivolol Approved, Investigational Phase 4 99200-09-6, 118457-14-0, 152520-56-4 71301
Enalaprilat Approved Phase 4 76420-72-9 6917719
Ramipril Approved Phase 4 87333-19-5 5362129
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
Eplerenone Approved Phase 4 107724-20-9 150310 443872
Bisoprolol Approved Phase 4 66722-44-9 2405
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
Captopril Approved Phase 4 62571-86-2 44093
Abciximab Approved Phase 4 143653-53-6
Tirofiban Approved Phase 4 144494-65-5 60947
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Iodine Approved, Investigational Phase 4 7553-56-2 807
Povidone-iodine Approved Phase 4 25655-41-8
Povidone Approved Phase 4 9003-39-8
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
Tenecteplase Approved Phase 4 191588-94-0
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
Candesartan Experimental Phase 4 139481-59-7 2541
26 Adrenergic beta-Antagonists Phase 4
27 Mineralocorticoid Receptor Antagonists Phase 4
28 Mineralocorticoids Phase 4
29 Angiotensin Receptor Antagonists Phase 4
30 Angiotensin-Converting Enzyme Inhibitors Phase 4
31 Adrenergic Antagonists Phase 4
32 Anticoagulants Phase 4
33 Adrenergic alpha-Antagonists Phase 4
34 Adrenergic alpha-1 Receptor Antagonists Phase 4
35 Hypolipidemic Agents Phase 4
36 Lipid Regulating Agents Phase 4
37 Antimetabolites Phase 4
38 Chlorhexidine gluconate Phase 4
39 Anti-Infective Agents, Local Phase 4
40 Plasma Substitutes Phase 4
41 Anti-Infective Agents Phase 4
42 cadexomer iodine Phase 4
43 Disinfectants Phase 4
44 Blood Substitutes Phase 4
45 Neurotransmitter Agents Phase 4
46 calcium heparin Phase 4
47 Purinergic P2Y Receptor Antagonists Phase 4
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
Pioglitazone Approved, Investigational Phase 3 111025-46-8 4829
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314

Interventional clinical trials:

(show top 50) (show all 98)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding Patients to Cardiac Resynchronization Therapy: the STOP-CRT Trial Completed NCT02200822 Phase 4 beta blockers;RAAS blockers
3 Effect of Cardiac Resynchronization Therapy on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
4 FATA: Comparison Between Tirofiban and Abciximab in Facilitated Angioplasty With Stent Implantation: Randomized Multicentre Study Completed NCT00383136 Phase 4 tirofiban high-bolus dose regimen;Abciximab
5 Benign Prostatic Hyperplasia and Ischemic Heart DIsease Completed NCT03856242 Phase 4 Tamsulosin Oral Capsule
6 A Randomised Trial on Early Stress Nuclear Scan for Patients Presented to the Emergency Department (ED) With Chest Pain But Non-diagnostic Electrocardiography-Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
7 Early Effect Of Bezafibrate On Fibrinogen Levels, Inflammatory Response And Clinical Impact, In Patients With ST Elevation Acute Myocardial Infarction Completed NCT02291796 Phase 4 Bezafibrate
8 Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation Active, not recruiting NCT01841242 Phase 4 alcoholic povidone iodine;alcoholic chlorhexidine
9 TRIANA: A Randomized Trial to Compare the Efficay and Safety of Thrombolysis With Primary Angioplasty as Initial Reperfusion Therapy in Older Patients (>= 75 Years Old) With Acute Myocardial Infarction Terminated NCT00257309 Phase 4 Tenecteplase + UFH (+ clopidogrel, since 01/97)
10 The Assessment of Cardiac Magnetic Resonance Imaging Guided Left Ventricular Lead Placement During the Implantation of Cardiac Resynchronisation Therapy on Clinical Outcomes in Patients With Chronic Heart Failure Unknown status NCT01417624 Phase 3
11 Prevention of Coronary Artery in STENT Restenosis With the Combined Use of Pioglitazone and Sirolimus-Eluting Coronary Stent Unknown status NCT00376870 Phase 3 Pioglitazone;Placebo
12 Study to Evaluate the Efficacy and Safety of Paclitaxel Eluting Balloon in St Elevation Myocardial Infarction After Bare Metal Stent Insertion Completed NCT01839890 Phase 3
13 CABG Off or On Pump Revascularization Study (CORONARY) Completed NCT00463294 Phase 3
14 The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute ST-segment Elevation Myocardial Infarction (RECONSIDER) Active, not recruiting NCT03371784 Phase 2, Phase 3 Hydrocortisone;Placebo
15 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
16 MADIT ASIA Cardiac Resynchronization Trial (MADIT-ASIA) Terminated NCT01872234 Phase 3
17 Bivalirudin Infusion for Ventricular Infarction Limitation Terminated NCT02565147 Phase 3 Bivalirudin;Heparin
18 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
19 Intracoronary Injection of Melatonin for Patients With ST-elevation Myocardial Infarction: a Placebo Controlled Randomized Study Completed NCT01172171 Phase 2 Melatonin, N-acetyl-5-methoxytryptamine;Isotonic saline, Natrium chloride
20 Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study Completed NCT01006863 Phase 2 Ephedrine;Placebo;Phenylephrine
21 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
22 Phase 1 Study to Assess the Safety of 500mg of Aspirin Added to IV TPA at Standard Doses to Prevent Re-occlusion of Cerebral Vessels After Successful Reperfusion. Withdrawn NCT00417898 Phase 1 Aspirin
23 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
24 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
25 Predictives Factors of Cardiac Resynchronization Therapy: a Multimodal Analysis Using 2D Speckle Tracking Echocardiography Coupled With MIBG Myocardial Scintigraphy and Heart Failure Biomarkers Unknown status NCT02018029
26 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
27 Comparison Between Standard and Bedside Ultrasound Integrated Approach for Risk Stratification of Patients Presenting With Syncope in the Emergency Department Unknown status NCT02781207
28 Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy Unknown status NCT03415945
29 Relevamiento / Encuesta Nacional de Infarto Agudo de Miocardio Con elevación Del ST Unknown status NCT02458885
30 Paced Electrocardiogram Requiring Fast Emergent Coronary Therapy (PERFECT) Study Unknown status NCT02765477
31 Effect of Bi-ventricular Pacing on Autonomous Nervous System Unknown status NCT00190138
32 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
33 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
34 The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and Efficiency Completed NCT00704093
35 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
36 Triple-site Biventricular Stimulation in the Optimization of Cardiac Resynchronization Therapy (CRT) Completed NCT02350842
37 Study of High Sensitive Troponin-I Level in End-stage Renal Disease Patients Receiving Hemodialysis Completed NCT02572466
38 Prognostic Impact of Combined Contrast-Induced Acute Kidney Injury and Hypoxic Liver Injury in Patients With ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Completed NCT02800421
39 Prevalence of Myocardial Injury in Gastrointestinal Surgery Patients - A Multi-center Prospective Cohort Study - POMY Completed NCT02885415
40 Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing. Completed NCT01652248
41 The Unidentified Association of Gated SPECT Abnormality With J Point Elevation Completed NCT03472898
42 Impact of Coronary Dye Injection Pressure on Myocardial Reperfusion During the Primary Percutaneous Coronary Intervention. Completed NCT03445364
43 Trhombus Aspiration in Hyperglycemic ST-elevation myocardiAl InfarcTIon (STEMI) Patients: 1-year Follow-up of the Prospective Randomised TAHITI Study Completed NCT02817542
44 Identifying High Risk Patients With Syncope Completed NCT00005202
45 Novel Methods for Arrhythmia Detection: Chest Strap ECG and Wrist Band Photoplethysmography Compared to Holter-device for Atrial Fibrillation Detection Completed NCT03721601
46 Tailor-CRT: Better Application of Cardiac Resynchronization Therapy by Automated and Improved Selection of Location and Timing of Stimulation Completed NCT02326493
47 Assessing the Capability of Cardiogoniometry (CGM) to Detect Changes in Cardiac Resynchronisation Therapy Device Settings Completed NCT02803879
48 COCHISE Pilot Study: Closed vs Open Cells Stent for High Risk Percutaneous Coronary Interventions in ST Elevation Acute Myocardial Infarction Completed NCT01152138
49 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
50 A Comparative Study of Different Treadmill Scores to Diagnose Coronary Artery Disease Among Patients Attending Bangabandhu Sheikh Mujib Medical University Completed NCT02879032

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Anatomical Context for Left Bundle Branch Hemiblock

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

Heart, Testes, Liver, Brain, Kidney, Prostate, Bone

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 4513)
# Title Authors PMID Year
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 61 54
19169971 2008
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 61 54
17710992 2007
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 54 61
11399338 2001
Post resuscitation electrocardiogram for coronary angiography indication after out-of-hospital cardiac arrest. 61
32295717 2020
The efficacy of left bundle branch area pacing compared with biventricular pacing in patients with heart failure: a matched case-control study. 61
32562442 2020
Interrelationships between interventricular electrical delays in cardiac resynchronization therapy. 61
32562444 2020
Risk Stratification of Patients With Apparently Idiopathic Premature Ventricular Contractions: A Multicenter International CMR Registry. 61
32553224 2020
Left bundle branch pacing. 61
32458056 2020
A Comparison of Left Ventricular Lead Upgrade versus Continued Medical Care Among Patients Eligible for Cardiac Resynchronization Therapy at the Time of Defibrillator Generator Replacement: Predictors of Left Ventricular Lead Upgrade and Associations with Long-term Outcomes. 61
32497762 2020
Do all intra-ventricular conduction defect ECG patterns respond equally to CRT? 61
31332607 2020
Clinical correlates and outcome of the patterns of premature ventricular beats in Olympic athletes: a long-term follow-up study. 61
32484042 2020
Machine Learning of 12-lead QRS Waveforms to Identify Cardiac Resynchronization Therapy Patients with Differential Outcomes. 61
32538136 2020
Coronary sinus and great cardiac vein electroanatomic mapping predicts the activation delay of the coronary sinus branches. 61
32525574 2020
Prognosis of incidental left bundle branch block. 61
32285097 2020
Elucidating the pathophysiology of left bundle branch block related perfusion defects. 61
32557149 2020
The use of His bundle pacing for the treatment of painful left bundle branch block syndrome. 61
32577257 2020
Septal flash is a prevalent and early dyssynchrony marker in transcatheter aortic valve replacement-induced left bundle branch block. 61
32056088 2020
A comparison of left bundle branch pacing with His bundle pacing in a patient with heart failure and left bundle branch block. 61
32577379 2020
Pre-Implantation Interlead ECG Heterogeneity Is Superior to QRS Complex Duration in Predicting Mechanical Super-Response in Patients with Non-Left Bundle Branch Block Receiving Cardiac Resynchronization Therapy. 61
32497764 2020
Left bundle branch pacing improved heart function in a 10-year-old child after a 3-month follow-up. 61
32529257 2020
[Indications for His bundle and left bundle branch pacing]. 61
32385573 2020
Contractile Fronts In The Interventricular Septum: A Case For High Frame Rate Echocardiographic Imaging. 61
32561068 2020
Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing. 61
32400967 2020
Clinical Characteristics and Outcomes of STEMI Patients With Cardiogenic Shock and Cardiac Arrest. 61
32438992 2020
His bundle pacing for newly acquired pacing needs in patients implanted with a subcutaneous implantable cardioverter defibrillator: A feasibility study based on the automated screening score and clinical cases. 61
32412155 2020
North American COVID-19 ST-segment elevation myocardial infarction (NACMI) registry: Rationale, design, and implications. 61
32425198 2020
Transcatheter radiofrequency ablation using near-zero fluoroscopy in children with fascicular ventricular tachycardia: a single-centre experience. 61
32383414 2020
Effect of transcatheter closure by AmplatzerTM Duct Occluder II in patients with small ventricular septal defect. 61
32462466 2020
Coronary venoplasty during cardiac resynchronization therapy device implantations: Acute results and clinical outcomes. 61
31862513 2020
Septal Flash-like Motion of the Earlier Activated Ventricular Wall Represents the Pathophysiology of Mechanical Dyssynchrony in Single-Ventricle Anatomy. 61
32089381 2020
Ablation of Supraventricular Tachycardias From Concealed Left-Sided Nodoventricular and Nodofascicular Accessory Pathways. 61
32286853 2020
Novel Predictors of New Persistent Left Bundle Branch Block After SAPIEN 3 Transcatheter Aortic Valve Replacement. 61
32061602 2020
Is left bundle branch block pattern on the ECG caused by variable ventricular activation sequence? 61
32270513 2020
Lead one ratio in left bundle branch block predicts poor cardiac resynchronization therapy response. 61
32285950 2020
New-Onset Left Bundle Branch Block After Transcatheter Aortic Valve Implantation - Not a Harmless Bystander. 61
32389906 2020
Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy. 61
32405991 2020
Diagnostic CMR Imaging Criteria in Noncompaction Cardiomyopathy and the Yield of Genetic Testing. 61
32445794 2020
To what extent are perfusion defects seen by myocardial perfusion SPECT in patients with left bundle branch block related to myocardial infarction, ECG characteristics, and myocardial wall motion? 61
32451797 2020
Clinical Impact of New-Onset Left Bundle-Branch Block After Transcatheter Aortic Valve Implantation in the Japanese Population - A Single High-Volume Center Experience. 61
32224577 2020
Electrical wavefront fusion in heart failure patients with left bundle branch block and cardiac resynchronization therapy: Implications for optimization. 61
32526538 2020
His bundle pacing after failure of cardiac resynchronization therapy: a case study. 61
32420781 2020
High-density mapping-guided corrective HIS bundle pacing after failed CRT upgrade for persistent left superior vena cava. 61
32359082 2020
Right ventricular function assessed by cardiac magnetic resonance predicts the response to resynchronization therapy. 61
32108126 2020
Comparison between cardiac resynchronization therapy with and without defibrillator on long-term mortality: A propensity score matched analysis. 61
31570188 2020
Feasibility of His-bundle pacing in patients with conduction disorders following transcatheter aortic valve replacement. 61
31990128 2020
[Implantable cardiac device deactivation at the end of life]. 61
32202561 2020
Cost-effectiveness analysis of implantable cardiac devices in patients with systolic heart failure: a US perspective using real world data. 61
32207659 2020
Marital Status and Long-Term Outcomes in Mild Heart Failure Patients With an Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy With Defibrillator. 61
32088000 2020
Comparison of measures of ventricular delay on cardiac resynchronization therapy response. 61
31765805 2020
A novel risk model for mortality and hospitalization following cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy: the alpha-score. 61
32345229 2020

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.71 PKP2 DSP DSG2 DSC2
2 cornified envelope GO:0001533 9.46 PKP2 DSP DSG2 DSC2
3 troponin complex GO:0005861 9.43 TNNT2 TNNT1 TNNI3
4 cardiac myofibril GO:0097512 9.37 TNNT2 TNNI3
5 cardiac Troponin complex GO:1990584 9.32 TNNT2 TNNI3
6 desmosome GO:0030057 9.26 PKP2 DSP DSG2 DSC2
7 intercalated disc GO:0014704 9.02 SCN5A PKP2 DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.81 PKP2 DSP DSG2 DSC2
2 cell-cell adhesion GO:0098609 9.8 PKP2 DSP DSG2 DSC2
3 muscle contraction GO:0006936 9.77 TNNT2 TNNT1 TNNI3
4 cornification GO:0070268 9.76 PKP2 DSP DSG2 DSC2
5 regulation of blood pressure GO:0008217 9.7 REN NPPB ACE
6 muscle filament sliding GO:0030049 9.65 TNNT2 TNNT1 TNNI3
7 cardiac muscle contraction GO:0060048 9.62 TNNT2 TNNT1 TNNI3 SCN5A
8 skeletal muscle contraction GO:0003009 9.61 TNNT2 TNNT1 TNNI3
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.58 SCN5A PKP2
10 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A PKP2
11 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.58 TNNT2 TNNI3 PKP2
12 heart contraction GO:0060047 9.57 TNNI3 ACE
13 amyloid-beta metabolic process GO:0050435 9.56 REN ACE
14 negative regulation of ATPase activity GO:0032780 9.55 TNNT2 TNNI3
15 angiotensin maturation GO:0002003 9.54 REN ACE
16 regulation of muscle contraction GO:0006937 9.54 TNNT2 TNNT1 TNNI3
17 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.46 PKP2 DSP DSG2 DSC2
18 desmosome organization GO:0002934 9.43 PKP2 DSP DSG2
19 regulation of heart rate by cardiac conduction GO:0086091 9.35 SCN5A PKP2 DSP DSG2 DSC2
20 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 8.92 PKP2 DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tropomyosin binding GO:0005523 9.32 TNNT2 TNNT1
2 calcium-dependent ATPase activity GO:0030899 9.26 TNNT2 TNNT1
3 troponin T binding GO:0031014 9.16 TNNT1 TNNI3
4 troponin C binding GO:0030172 8.96 TNNT2 TNNI3
5 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.92 PKP2 DSP DSG2 DSC2

Sources for Left Bundle Branch Hemiblock

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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