MCID: LFT001
MIFTS: 49

Left Bundle Branch Hemiblock

Categories: Cardiovascular diseases

Aliases & Classifications for Left Bundle Branch Hemiblock

MalaCards integrated aliases for Left Bundle Branch Hemiblock:

Name: Left Bundle Branch Hemiblock 12 15 71
Left Bundle Branch Block 12 54 15
Left Bundle-Branch Block 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10272
ICD9CM 34 426.2
SNOMED-CT 67 4973001
ICD10 32 I44.60 I44.7
UMLS 71 C0023211 C0155702

Summaries for Left Bundle Branch Hemiblock

MalaCards based summary : Left Bundle Branch Hemiblock, also known as left bundle branch block, is related to third-degree atrioventricular block and second-degree atrioventricular block. An important gene associated with Left Bundle Branch Hemiblock is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Valsartan and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are cardiovascular system and embryo

Related Diseases for Left Bundle Branch Hemiblock

Diseases related to Left Bundle Branch Hemiblock via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 third-degree atrioventricular block 32.4 SCN5A NPPB ACE
2 second-degree atrioventricular block 32.4 TNNI3 SCN5A
3 first-degree atrioventricular block 31.9 SCN5A LMNA CRP ACE
4 arrhythmogenic right ventricular dysplasia, familial, 1 31.7 TMEM43 RYR2 PKP2 JUP DSP DSG2
5 cardiogenic shock 31.2 NPPB CRP
6 anterolateral myocardial infarction 31.2 NPPB ACE
7 mitral valve insufficiency 31.2 TNNT2 TNNI3 NPPB CRP ACE
8 arteries, anomalies of 31.2 TNNT2 TNNI3 P2RY12 NPPB CRP ACE
9 wolff-parkinson-white syndrome 31.1 TNNT2 TNNT1 TNNI3 SCN5A NPPB
10 inferior myocardial infarction 31.0 PIK3C2A NPPB
11 systolic heart failure 31.0 NR3C2 NPPB CRP ACE
12 hypertensive heart disease 31.0 NR3C2 NPPB ACE
13 atrioventricular block 30.9 TNNI3 SCN5A RYR2 PIK3C2A NPPB LMNA
14 aortic valve insufficiency 30.9 NPPB CRP ACE
15 tricuspid valve insufficiency 30.8 TNNI3 NPPB CRP ACE
16 ventricular fibrillation, paroxysmal familial, 1 30.8 TNNT2 SCN5A RYR2 DSP
17 diastolic heart failure 30.7 TNNI3 NPPB ACE
18 coronary stenosis 30.7 TNNI3 PIK3C2A NPPB CRP ACE
19 acute myocarditis 30.7 TNNI3 NPPB CRP ACE
20 angina pectoris 30.6 TNNI3 PIK3C2A NPPB CRP ACE
21 patent ductus arteriosus 1 30.6 NPPB CRP ACE
22 cardiac conduction defect 30.6 SCN5A RYR2 LMNA DSP
23 pulmonary embolism 30.5 TNNT2 TNNT1 TNNI3 NPPB CRP ACE
24 heart valve disease 30.5 TNNT2 TNNI3 NR3C2 NPPB CRP ACE
25 mitral valve disease 30.5 TNNI3 NPPB CRP ACE
26 myocarditis 30.4 TNNI3 PIK3C2A NPPB DSP ACE
27 cardiac arrhythmia 30.4 SCN5A RYR2 PKP2 JUP
28 atrial heart septal defect 30.4 TNNT2 TNNI3 SCN5A NPPB CRP ACE
29 right bundle branch block 30.4 TNNI3 SCN5A PKP2 NPPB NACC2 ACE
30 aortic valve disease 2 30.2 TNNT2 TNNI3 NPPB CRP ACE
31 endocarditis 30.1 TNNI3 PIK3C2A CRP
32 acute myocardial infarction 30.0 TNNT2 TNNI3 PIK3C2A NR3C2 NPPB ITGA2B
33 coronary artery anomaly 30.0 TNNT2 TNNT1 TNNI3 SCN5A RYR2 PIK3C2A
34 coronary artery vasospasm 30.0 TNNI3 PIK3C2A CRP ACE
35 hypokalemia 29.9 PIK3C2A NR3C2 ACE
36 lateral myocardial infarction 29.9 PIK3C2A NACC2 ITGA2B
37 chronic kidney disease 29.8 TNNT2 TNNI3 NR3C2 NPPB CRP ACE
38 respiratory failure 29.8 PIK3C2A NPPB CRP ACE
39 cardiac tamponade 29.8 TNNI3 PIK3C2A NPPB CRP ACE
40 pulmonary edema 29.7 TNNT2 TNNI3 PIK3C2A NR3C2 NPPB CRP
41 hypertrophic cardiomyopathy 29.7 TNNT2 TNNT1 TNNI3 SCN5A RYR2 LMNA
42 congestive heart failure 29.6 TNNT2 TNNI3 SCN5A RYR2 PIK3C2A NR3C2
43 tetralogy of fallot 29.6 TNNT2 TNNI3 SCN5A RYR2 NPPB CRP
44 atrial fibrillation 29.4 TNNT2 TNNI3 SCN5A RYR2 NR3C2 NPPB
45 rare cardiomyopathy 29.2 TNNT2 TNNI3 RYR2 PKP2 LMNA DSP
46 intermediate coronary syndrome 29.2 TNNT2 TNNT1 TNNI3 PIK3C2A P2RY12 ITGA2B
47 long qt syndrome 29.1 TMEM43 SCN5A RYR2 PKP2 LMNA DSP
48 myocardial infarction 29.1 TNNT2 TNNT1 TNNI3 SCN5A PIK3C2A P2RY12
49 atrial standstill 1 29.0 TNNT2 TNNI3 SCN5A RYR2 PKP2 NPPB
50 cardiac arrest 28.9 TNNT2 TMEM43 SCN5A RYR2 PIK3C2A NPPB

Comorbidity relations with Left Bundle Branch Hemiblock via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Respiratory Failure Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Left Bundle Branch Hemiblock:



Diseases related to Left Bundle Branch Hemiblock

Symptoms & Phenotypes for Left Bundle Branch Hemiblock

MGI Mouse Phenotypes related to Left Bundle Branch Hemiblock:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 ACE CRP DSC2 DSG2 DSP ITGA2B
2 embryo MP:0005380 9.81 ACE DSP ITGA2B JUP PIK3C2A RYR2
3 mortality/aging MP:0010768 9.77 ACE DSG2 DSP JUP LMNA NR3C2
4 muscle MP:0005369 9.36 DSG2 DSP JUP LMNA NR3C2 PKP2

Drugs & Therapeutics for Left Bundle Branch Hemiblock

Drugs for Left Bundle Branch Hemiblock (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
3
Eplerenone Approved Phase 4 107724-20-9 150310 443872
4
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
5
Bisoprolol Approved Phase 4 66722-44-9 2405
6
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
7
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
8
Captopril Approved Phase 4 62571-86-2 44093
9
Enalaprilat Approved Phase 4 76420-72-9 6917719
10
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
11
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
12
Ramipril Approved Phase 4 87333-19-5 5362129
13
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
14
Tirofiban Approved Phase 4 144494-65-5 60947
15
Abciximab Approved Phase 4 143653-53-6
16
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
17
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
18
Povidone Approved Phase 4 9003-39-8
19
Iodine Approved, Investigational Phase 4 7553-56-2 807
20
Povidone-iodine Approved Phase 4 25655-41-8
21
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
22
Tenecteplase Approved Phase 4 191588-94-0
23
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
24
Candesartan Experimental Phase 4 139481-59-7 2541
25 Adrenergic Antagonists Phase 4
26 Mineralocorticoids Phase 4
27 Mineralocorticoid Receptor Antagonists Phase 4
28 Natriuretic Agents Phase 4
29 Angiotensin-Converting Enzyme Inhibitors Phase 4
30 diuretics Phase 4
31 Angiotensin Receptor Antagonists Phase 4
32 Diuretics, Potassium Sparing Phase 4
33 Anticoagulants Phase 4
34 Adrenergic alpha-Antagonists Phase 4
35 Hypolipidemic Agents Phase 4
36 Antimetabolites Phase 4
37 Lipid Regulating Agents Phase 4
38 Micronutrients Phase 4
39 Trace Elements Phase 4
40 Anti-Infective Agents Phase 4
41 Chlorhexidine gluconate Phase 4
42 Nutrients Phase 4
43 Plasma Substitutes Phase 4
44 Dermatologic Agents Phase 4
45 Anti-Infective Agents, Local Phase 4
46 cadexomer iodine Phase 4
47 Disinfectants Phase 4
48 Blood Substitutes Phase 4
49 Neurotransmitter Agents Phase 4
50 calcium heparin Phase 4

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB) After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding Patients to Cardiac Resynchronization Therapy: the STOP-CRT Trial Completed NCT02200822 Phase 4 beta blockers;RAAS blockers
3 Effect of Cardiac Resynchronization Therapy on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response Completed NCT01019915 Phase 4
4 FATA: Comparison Between Tirofiban and Abciximab in Facilitated Angioplasty With Stent Implantation: Randomized Multicentre Study Completed NCT00383136 Phase 4 tirofiban high-bolus dose regimen;Abciximab
5 Benign Prostatic Hyperplasia and Ischemic Heart DIsease Completed NCT03856242 Phase 4 Tamsulosin Oral Capsule
6 A Randomised Trial on Early Stress Nuclear Scan for Patients Presented to the Emergency Department (ED) With Chest Pain But Non-diagnostic Electrocardiography-Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
7 Early Effect Of Bezafibrate On Fibrinogen Levels, Inflammatory Response And Clinical Impact, In Patients With ST Elevation Acute Myocardial Infarction Completed NCT02291796 Phase 4 Bezafibrate
8 Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation Active, not recruiting NCT01841242 Phase 4 alcoholic povidone iodine;alcoholic chlorhexidine
9 TRIANA: A Randomized Trial to Compare the Efficay and Safety of Thrombolysis With Primary Angioplasty as Initial Reperfusion Therapy in Older Patients (>= 75 Years Old) With Acute Myocardial Infarction Terminated NCT00257309 Phase 4 Tenecteplase + UFH (+ clopidogrel, since 01/97)
10 The Assessment of Cardiac Magnetic Resonance Imaging Guided Left Ventricular Lead Placement During the Implantation of Cardiac Resynchronisation Therapy on Clinical Outcomes in Patients With Chronic Heart Failure Unknown status NCT01417624 Phase 3
11 Prevention of Coronary Artery in STENT Restenosis With the Combined Use of Pioglitazone and Sirolimus-Eluting Coronary Stent Unknown status NCT00376870 Phase 3 Pioglitazone;Placebo
12 Study to Evaluate the Efficacy and Safety of Paclitaxel Eluting Balloon in St Elevation Myocardial Infarction After Bare Metal Stent Insertion Completed NCT01839890 Phase 3
13 CABG Off or On Pump Revascularization Study (CORONARY) Completed NCT00463294 Phase 3
14 Study to Evaluate the Efficacy and Safety of Paclitaxel Eluting Balloon After Bare Metal Stent Implantation Versus Drug-eluting Stent in St Elevation Myocardial Infarction Recruiting NCT03610347 Phase 3
15 The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute ST-segment Elevation Myocardial Infarction (RECONSIDER) Recruiting NCT03371784 Phase 2, Phase 3 Hydrocortisone;Placebo
16 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
17 MADIT ASIA Cardiac Resynchronization Trial (MADIT-ASIA) Terminated NCT01872234 Phase 3
18 Bivalirudin Infusion for Ventricular Infarction Limitation Terminated NCT02565147 Phase 3 Bivalirudin;Heparin
19 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
20 Intracoronary Injection of Melatonin for Patients With ST-elevation Myocardial Infarction: a Placebo Controlled Randomized Study Completed NCT01172171 Phase 2 Melatonin, N-acetyl-5-methoxytryptamine;Isotonic saline, Natrium chloride
21 Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study Completed NCT01006863 Phase 2 Ephedrine;Placebo;Phenylephrine
22 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
23 Phase 1 Study to Assess the Safety of 500mg of Aspirin Added to IV TPA at Standard Doses to Prevent Re-occlusion of Cerebral Vessels After Successful Reperfusion. Withdrawn NCT00417898 Phase 1 Aspirin
24 Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block Unknown status NCT01494870
25 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
26 Predictives Factors of Cardiac Resynchronization Therapy: a Multimodal Analysis Using 2D Speckle Tracking Echocardiography Coupled With MIBG Myocardial Scintigraphy and Heart Failure Biomarkers Unknown status NCT02018029
27 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
28 Comparison Between Standard and Bedside Ultrasound Integrated Approach for Risk Stratification of Patients Presenting With Syncope in the Emergency Department Unknown status NCT02781207
29 Effect of Bi-ventricular Pacing on Autonomous Nervous System Unknown status NCT00190138
30 Relevamiento / Encuesta Nacional de Infarto Agudo de Miocardio Con elevación Del ST Unknown status NCT02458885
31 Paced Electrocardiogram Requiring Fast Emergent Coronary Therapy (PERFECT) Study Unknown status NCT02765477
32 Cardiac Resynchronization Therapy (CRT) Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT). A Prospective, Randomized, Postmarket, Pilot Study. Completed NCT01983293
33 Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging Completed NCT00269659
34 The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and Efficiency Completed NCT00704093
35 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
36 Triple-site Biventricular Stimulation in the Optimization of Cardiac Resynchronization Therapy (CRT) Completed NCT02350842
37 Study of High Sensitive Troponin-I Level in End-stage Renal Disease Patients Receiving Hemodialysis Completed NCT02572466
38 Prognostic Impact of Combined Contrast-Induced Acute Kidney Injury and Hypoxic Liver Injury in Patients With ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Completed NCT02800421
39 Prevalence of Myocardial Injury in Gastrointestinal Surgery Patients - A Multi-center Prospective Cohort Study - POMY Completed NCT02885415
40 Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing. Completed NCT01652248
41 Impact of Coronary Dye Injection Pressure on Myocardial Reperfusion During the Primary Percutaneous Coronary Intervention. Completed NCT03445364
42 The Unidentified Association of Gated SPECT Abnormality With J Point Elevation Completed NCT03472898
43 Trhombus Aspiration in Hyperglycemic ST-elevation myocardiAl InfarcTIon (STEMI) Patients: 1-year Follow-up of the Prospective Randomised TAHITI Study Completed NCT02817542
44 Novel Methods for Arrhythmia Detection: Chest Strap ECG and Wrist Band Photoplethysmography Compared to Holter-device for Atrial Fibrillation Detection Completed NCT03721601
45 Identifying High Risk Patients With Syncope Completed NCT00005202
46 Tailor-CRT: Better Application of Cardiac Resynchronization Therapy by Automated and Improved Selection of Location and Timing of Stimulation Completed NCT02326493
47 Assessing the Capability of Cardiogoniometry (CGM) to Detect Changes in Cardiac Resynchronisation Therapy Device Settings Completed NCT02803879
48 COCHISE Pilot Study: Closed vs Open Cells Stent for High Risk Percutaneous Coronary Interventions in ST Elevation Acute Myocardial Infarction Completed NCT01152138
49 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
50 Multipolar Pacing by Cardiac Resynchronization Therapy With a Defibrillator as Treatment in Type 2 Diabetes Mellitus Failing Heart Patients: Impact on Responders Rate, and Clinical Outcomes. Completed NCT03095196 HF drugs

Search NIH Clinical Center for Left Bundle Branch Hemiblock

Genetic Tests for Left Bundle Branch Hemiblock

Anatomical Context for Left Bundle Branch Hemiblock

MalaCards organs/tissues related to Left Bundle Branch Hemiblock:

40
Heart, Testes, Kidney, Liver, Brain, Prostate, Bone

Publications for Left Bundle Branch Hemiblock

Articles related to Left Bundle Branch Hemiblock:

(show top 50) (show all 4430)
# Title Authors PMID Year
1
Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology. 54 61
19169971 2008
2
Feasibility, safety, and mid-term efficacy of cardiac resynchronization therapy in patients with severe heart failure and ventricular conduction delay: Chulalongkorn experience. 54 61
17710992 2007
3
Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. 54 61
11399338 2001
4
Differences in presentation and clinical outcomes between left or right bundle branch block and ST segment elevation in patients with acute myocardial infarction. 61
32030999 2020
5
Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block. 61
31599327 2020
6
A narrow QRS complex during a left bundle branch block morphology wide QRS tachycardia: A clue for manifest or bystander involvement of nodofascicular pathway? 61
31916620 2020
7
An S wave in ECG lead V6 predicts poor response to cardiac resynchronization therapy and long-term outcome. 61
31513944 2020
8
A 63-year-old woman with multiple secondary tumours. 61
31915242 2020
9
Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy. 61
31908084 2020
10
Can the 12-lead ECG distinguish RVOT from aortic cusp PVCs in pediatric patients? 61
32040211 2020
11
Left bundle branch block-induced cardiomyopathy: Myth or reality? 61
31477316 2020
12
A single-centre cohort and short-term follow-up of patients who developed persistent new onset left bundle branch block after transcatheter aortic valve replacement. 61
31984845 2020
13
Comparison of Quantitative Perfusion and Function Parameters of Gated-SPECT Myocardial Perfusion Imaging in Patients With Concordant and Discordant Left Bundle-Branch Block. 61
31789912 2020
14
Expanding benefits from cardiac resynchronization therapy to exercise-induced left bundle branch block in advanced heart failure. 61
31923352 2020
15
Detection of strict left bundle branch block by neural network and a method to test detection consistency. 61
31962304 2020
16
Typical BBB morphology and implantation depth of 3830 electrode predict QRS correction by left bundle branch area pacing. 61
31773756 2020
17
Novel ultra-high-frequency electrocardiogram tool for the description of the ventricular depolarization pattern before and during cardiac resynchronization. 61
31788894 2020
18
Clinical impact of conduction disturbances in transcatheter aortic valve replacement recipients: a systematic review and meta-analysis. 61
31899484 2020
19
Different dynamics of new-onset electrocardiographic changes after balloon- and self-expandable transcatheter aortic valve replacement: Implications for prolonged heart rhythm monitoring. 61
32007908 2020
20
Feasibility of His-bundle pacing in patients with conduction disorders following transcatheter aortic valve replacement. 61
31990128 2020
21
CRT Survey II: a European Society of Cardiology (ESC) survey of cardiac resynchronization therapy-an Irish subset analysis. 61
31981072 2020
22
Septal contraction predicts acute haemodynamic improvement and paced QRS width reduction in cardiac resynchronization therapy. 61
31925420 2020
23
Early improvement of left ventricular ejection fraction by cardiac resynchronization through His bundle pacing in patients with heart failure. 61
31746996 2020
24
Oversensing issues leading to device extraction: When subcutaneous implantable cardioverter-defibrillator reached a dead-end. 61
31295585 2020
25
The heart remembers what the mind forgets. 61
31996105 2020
26
Importance of Preoperative Computed Tomography Assessment of the Membranous Septal Anatomy in Patients Undergoing Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve. 61
31902829 2020
27
CHA2DS2-VASc Score and the Risk of Ventricular Tachyarrhythmic Events and Mortality in MADIT-CRT. 61
31888428 2020
28
Characterization of Structural Changes in Arrhythmogenic Right Ventricular Cardiomyopathy With Recurrent Ventricular Tachycardia After Ablation: Insights From Repeat Electroanatomic Voltage Mapping. 61
31922914 2020
29
Sex Differences in the Long-term Prognosis of Dilated Cardiomyopathy. 61
31515085 2020
30
Quantitative mechanical dyssynchrony in dilated cardiomyopathy measured by deformable registration algorithm. 61
31953665 2020
31
Left bundle branch block-induced cardiomyopathy: a diagnostic proposal for a poorly explored pathological entity. 61
31186131 2020
32
Rare Association of Takotsubo Cardiomyopathy with Right Bundle Branch Block in the Dual Setting of Asthma Exacerbation and Psychiatric Illness. 61
31959739 2020
33
Left Bundle Branch Block Increases Left Ventricular Diastolic Pressure during Tachycardia due to Incomplete Relaxation. 61
31999529 2020
34
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy. 61
31954643 2020
35
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar. 61
30772230 2019
36
Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. 61
31889524 2019
37
Outcomes after pacemaker implantation in patients with new-onset left bundle-branch block after transcatheter aortic valve replacement. 61
31806088 2019
38
Cardiac resynchronization therapy by left bundle branch area pacing in patients with heart failure and left bundle branch block. 61
31513945 2019
39
Absence of left bundle branch block and blood urea nitrogen predict improvement in left ventricular ejection fraction in patients with cardiomyopathy and wearable cardioverter defibrillators. 61
31860745 2019
40
Comparison of Usefulness of Cardiac Resynchronization Therapy in Patients With Type 1 Myotonic Dystrophy With Versus Without Left Bundle Branch Block. 61
31586533 2019
41
The QR-max index, a novel electrocardiographic index for the determination of left ventricular conduction delay and selection of cardiac resynchronization in patients with non-left bundle branch block. 61
31807986 2019
42
[Transcatheter aortic valve implantation and conduction disturbances]. 61
31668339 2019
43
Utility of 30-Day Continuous Ambulatory Monitoring to Identify Patients With Delayed Occurrence of Atrioventricular Block After Transcatheter Aortic Valve Replacement. 61
31833417 2019
44
Spanish Results of the Second European Cardiac Resynchronization Therapy Survey (CRT-Survey II). 61
30935899 2019
45
Prospective evaluation of feasibility and electrophysiologic and echocardiographic characteristics of left bundle branch area pacing. 61
31136869 2019
46
Left Bundle Branch Pacing: JACC Review Topic of the Week. 61
31865972 2019
47
Cardiac resynchronization therapy following Carillon® annuloplasty device for symptomatic heart failure and functional mitral regurgitation: a case report. 61
31911977 2019
48
The electrocardiogram of ventricular capture during transcutaneous cardiac pacing. 61
31838311 2019
49
Coronary venoplasty during cardiac resynchronization therapy device implantations: Acute results and clinical outcomes. 61
31862513 2019
50
Mitral Annulus Calcium Score. 61
30636515 2019

Variations for Left Bundle Branch Hemiblock

Expression for Left Bundle Branch Hemiblock

Search GEO for disease gene expression data for Left Bundle Branch Hemiblock.

Pathways for Left Bundle Branch Hemiblock

Pathways related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 TNNT2 TNNT1 TNNI3 SCN5A RYR2
2
Show member pathways
12.27 TNNT2 TNNI3 SCN5A RYR2 NPPB
3 12.21 TNNT2 TNNI3 LMNA JUP ITGA2B
4
Show member pathways
12.11 PKP2 JUP DSP DSG2 DSC2
5
Show member pathways
11.9 TNNT2 TNNI3 RYR2 LMNA ITGA2B ACE
6 11.57 TNNT2 TNNI3 RYR2
7 11.47 TNNT2 TNNT1 TNNI3
8
Show member pathways
11.41 RYR2 PKP2 LMNA JUP ITGA2B DSP
9 11.3 TNNT2 TNNI3 SCN5A
10 11.1 SCN5A RYR2 LMNA JUP DSP

GO Terms for Left Bundle Branch Hemiblock

Cellular components related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.78 PKP2 LMNA JUP DSP
2 cell-cell junction GO:0005911 9.72 PKP2 JUP DSP DSG2 DSC2
3 cell-cell adherens junction GO:0005913 9.69 PKP2 JUP DSC2
4 sarcomere GO:0030017 9.63 TNNT2 TNNI3 RYR2
5 lateral plasma membrane GO:0016328 9.58 SCN5A JUP DSG2
6 cornified envelope GO:0001533 9.55 PKP2 JUP DSP DSG2 DSC2
7 fascia adherens GO:0005916 9.49 JUP DSP
8 cardiac myofibril GO:0097512 9.43 TNNT2 TNNI3
9 troponin complex GO:0005861 9.43 TNNT2 TNNT1 TNNI3
10 cardiac Troponin complex GO:1990584 9.37 TNNT2 TNNI3
11 desmosome GO:0030057 9.35 PKP2 JUP DSP DSG2 DSC2
12 intercalated disc GO:0014704 9.1 SCN5A PKP2 JUP DSP DSG2 DSC2

Biological processes related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.85 PKP2 JUP DSP DSG2 DSC2
2 muscle contraction GO:0006936 9.77 TNNT2 TNNT1 TNNI3
3 cell-cell adhesion GO:0098609 9.77 PKP2 JUP DSP DSG2 DSC2
4 cornification GO:0070268 9.72 PKP2 JUP DSP DSG2 DSC2
5 muscle filament sliding GO:0030049 9.69 TNNT2 TNNT1 TNNI3
6 skeletal muscle contraction GO:0003009 9.67 TNNT2 TNNT1 TNNI3
7 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.65 TNNT2 TNNI3 PKP2
8 cardiac muscle contraction GO:0060048 9.65 TNNT2 TNNT1 TNNI3 SCN5A RYR2
9 regulation of heart rate by cardiac conduction GO:0086091 9.63 SCN5A PKP2 JUP DSP DSG2 DSC2
10 ventricular cardiac muscle cell action potential GO:0086005 9.61 SCN5A RYR2 PKP2
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.59 SCN5A PKP2
12 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A PKP2
13 heart contraction GO:0060047 9.58 TNNI3 ACE
14 regulation of muscle contraction GO:0006937 9.58 TNNT2 TNNT1 TNNI3
15 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.57 RYR2 PKP2
16 negative regulation of ATPase activity GO:0032780 9.56 TNNT2 TNNI3
17 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.55 TNNI3 RYR2
18 desmosome organization GO:0002934 9.54 DSP DSG2
19 desmosome assembly GO:0002159 9.52 PKP2 JUP
20 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.35 PKP2 JUP DSP DSG2 DSC2
21 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.1 RYR2 PKP2 JUP DSP DSG2 DSC2

Molecular functions related to Left Bundle Branch Hemiblock according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.8 TNNT2 TNNT1 RYR2 DSG2 DSC2 CRP
2 cell adhesion molecule binding GO:0050839 9.54 JUP DSP DSG2
3 tropomyosin binding GO:0005523 9.43 TNNT2 TNNT1
4 alpha-catenin binding GO:0045294 9.4 PKP2 JUP
5 troponin T binding GO:0031014 9.26 TNNT1 TNNI3
6 calcium-dependent ATPase activity GO:0030899 9.16 TNNT2 TNNT1
7 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.02 PKP2 JUP DSP DSG2 DSC2
8 troponin C binding GO:0030172 8.96 TNNT2 TNNI3

Sources for Left Bundle Branch Hemiblock

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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