Left Ventricular Noncompaction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Left Ventricular Noncompaction

MalaCards integrated aliases for Left Ventricular Noncompaction:

Name: Left Ventricular Noncompaction ¹¹ ¹⁹ ⁴² ⁵⁸ ²⁸ ⁵ ¹⁴ ⁷¹ ³³

Noncompaction Cardiomyopathy ⁴² ⁵ ⁷¹ ⁷⁵ ³³

Left Ventricular Hypertrabeculation ¹¹ ¹⁹ ⁴² ⁵⁸

Isolated Noncompaction of the Ventricular Myocardium ⁴² ⁵ ¹⁶

Spongy Myocardium ¹⁹ ⁴² ⁵⁸

Lvnc ¹⁹ ⁴² ⁵⁸

Left Ventricular Myocardial Noncompaction Cardiomyopathy ⁴² ⁷¹

Non-Compaction of the Left Ventricular Myocardium ⁴²

Left Ventricular Non-Compaction ⁴²

Ventricular Noncompaction, Left ³⁸

Non-Compaction Cardiomyopathy ¹⁶

Hypertrabeculation Syndrome ⁴²

Honeycomb Myocardium ⁴²

Fetal Myocardium ⁴²

Lvht ⁴²

Characteristics:

Inheritance:

Autosomal dominant,Autosomal recessive,Mitochondrial inheritance,X-linked recessive ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases Genetic diseases
Anatomical: Cardiovascular diseases Muscle diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the circulatory system

Other forms of heart disease

Cardiomyopathy

Other cardiomyopathies

ICD11: ³³

Diseases of the circulatory system

Diseases of the myocardium or cardiac chambers

Noncompaction cardiomyopathy

External Ids:

Disease Ontology ¹¹ DOID:0060480

ICD10 via Orphanet ³² I42.8

UMLS via Orphanet ⁷² C1960469

Orphanet ⁵⁸ ORPHA54260

EFO ¹⁶ EFO_0004686 EFO_1001802

ICD11 ³³ 226977635

UMLS ⁷¹ C1839832 C1960469 C3164472

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Summaries for Left Ventricular Noncompaction

MedlinePlus Genetics: ⁴² Left ventricular noncompaction is a heart (cardiac) muscle disorder that occurs when the lower left chamber of the heart (left ventricle), which helps the heart pump blood, does not develop correctly. Instead of the muscle being smooth and firm, the cardiac muscle in the left ventricle is thick and appears spongy. The abnormal cardiac muscle is weak and has an impaired ability to pump blood because it either cannot completely contract or it cannot completely relax. For the heart to pump blood normally, cardiac muscle must contract and relax fully.Some individuals with left ventricular noncompaction experience no symptoms at all; others have heart problems that can include sudden cardiac death. Additional signs and symptoms include abnormal blood clots, irregular heart rhythm (arrhythmia), a sensation of fluttering or pounding in the chest (palpitations), extreme fatigue during exercise (exercise intolerance), shortness of breath (dyspnea), fainting (syncope), swelling of the legs (lymphedema), and trouble laying down flat. Some affected individuals have features of other heart defects. Left ventricular noncompaction can be diagnosed at any age, from birth to late adulthood. Approximately two-thirds of individuals with left ventricular noncompaction develop heart failure.

MalaCards based summary: Left Ventricular Noncompaction, also known as noncompaction cardiomyopathy, is related to cardiomyopathy, dilated, 1e and left ventricular noncompaction 2. An important gene associated with Left Ventricular Noncompaction is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Cardiac conduction and Cytoskeletal Signaling. Affiliated tissues include heart, kidney and skeletal muscle, and related phenotypes are homeostasis/metabolism and muscle

GARD: ¹⁹ Left ventricular noncompaction (LVNC) is a rare heart condition. In LVNC the inside wall of the heart is spongy or grooved, instead of smooth. Signs and symptoms of LVNC vary, but may cause life-threatening abnormal heart rhythms and weakness of the heart muscle.

Orphanet: ⁵⁸ A rare cardiomyopathy characterized anatomically by prominent left ventricular trabeculae and deep intratrabecular recesses causing progressive systolic and diastolic dysfunction, conduction abnormalities, and occasionally thromboembolic events.

Disease Ontology: ¹¹ An intrinsic cardiomyopathy characterized by distinctive (spongy) morphological appearance of the LV myocardium.

Wikipedia: ⁷⁵ Noncompaction cardiomyopathy (NCC) is a rare congenital disease of heart muscle that affects both... more...

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Related Diseases for Left Ventricular Noncompaction

Diseases in the Left Ventricular Noncompaction family:

Left Ventricular Noncompaction 1	Left Ventricular Noncompaction 2
Left Ventricular Noncompaction 7	Left Ventricular Noncompaction 8
Left Ventricular Noncompaction 10

Diseases related to Left Ventricular Noncompaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 516)

#	Related Disease	Score	Top Affiliating Genes
1	cardiomyopathy, dilated, 1e	33.8	TTN-AS1 TTN TPM1 SCN5A PKP2 MYH7
2	left ventricular noncompaction 2	33.4	TTN-AS1 TTN LVNC2
3	barth syndrome	33.0	TTN TNNT2 MYH7 MYBPC3 LMNA LDB3
4	dilated cardiomyopathy	32.4	TTN-AS1 TTN TPM1 TNNT2 SCN5A PLEKHM2
5	hypertrophic cardiomyopathy	32.3	TTN-AS1 TTN TPM1 TNNT2 SCN5A PKP2
6	cardiomyopathy, familial hypertrophic, 1	32.2	TTN TPM1 TNNT2 SCN5A NKX2-5 MYH7B
7	cardiac conduction defect	32.1	SCN5A MYH7 MYBPC3 LMNA
8	neuromuscular disease	31.9	TTN-AS1 TTN MYH7 LMNA LDB3 DTNA
9	ebstein anomaly	31.9	TTN TPM1 SCN5A NKX2-5 MYH7 MYBPC3
10	atrial standstill 1	31.9	SCN5A PKP2 MYH7 MYBPC3 LMNA LAMP2
11	heart septal defect	31.9	TNNT2 NKX2-5 MYH7 ACTC1
12	myopathy	31.9	TTN-AS1 TTN TPM1 TNNT2 MYH7 LMNA
13	congestive heart failure	31.9	TTN TNNT2 SCN5A MYH7 MYBPC3
14	heart disease	31.7	TTN TNNT2 SCN5A PKP2 NKX2-5 MYH7
15	aortic valve disease 2	31.7	TTN TNNT2 NKX2-5 MYH7 MYBPC3
16	atrial heart septal defect	31.7	TTN TNNT2 SCN5A NKX2-5 MYH7 MYBPC3
17	left bundle branch hemiblock	31.7	TTN TNNT2 SCN5A PKP2 MYBPC3 LMNA
18	mitral valve insufficiency	31.7	TTN TNNT2 MYH7 MYBPC3
19	patent ductus arteriosus 1	31.6	TTN TNNT2 NKX2-5 MYH7 MYBPC3 ACTC1
20	atrioventricular block	31.6	TNNT2 SCN5A NKX2-5 LMNA
21	muscular dystrophy	31.6	TTN-AS1 TTN TNNT2 MYH7 LMNA LDB3
22	lipoprotein quantitative trait locus	31.6	TTN TNNT2 SCN5A PKP2 NKX2-5 MYH7
23	syncope	31.5	TNNT2 SCN5A
24	brugada syndrome	31.5	TTN TPM1 TNNT2 SCN5A PKP2 NKX2-5
25	long qt syndrome	31.5	TTN TNNT2 SCN5A PKP2 NKX2-5 MYH7
26	cardiac arrest	31.4	TNNT2 SCN5A MYH7
27	peripartum cardiomyopathy	31.4	TTN MYH7 MYBPC3
28	wolff-parkinson-white syndrome	31.4	TTN-AS1 TTN TNNT2 SCN5A NKX2-5 MYH7
29	ventricular fibrillation, paroxysmal familial, 1	31.4	TNNT2 SCN5A
30	sick sinus syndrome	31.4	TTN SCN5A LMNA
31	tetralogy of fallot	31.4	TTN TPM1 TNNT2 SCN5A NKX2-5 MYH7
32	restrictive cardiomyopathy	31.4	TTN-AS1 TTN TPM1 TNNT2 SCN5A PKP2
33	myocarditis	31.4	TTN TNNT2 MYH7 LMNA
34	catecholaminergic polymorphic ventricular tachycardia	31.3	TTN TNNT2 SCN5A PKP2 MYH7 MYBPC3
35	right bundle branch block	31.3	TNNT2 SCN5A PKP2
36	third-degree atrioventricular block	31.3	TTN-AS1 TTN SCN5A NKX2-5 LMNA
37	endocardial fibroelastosis	31.3	NKX2-5 MYH7 LDB3 ACTC1
38	cardiomyopathy, dilated, 1dd	31.2	TTN TNNT2 LDB3
39	patent foramen ovale	31.2	TTN TNNT2 SCN5A NKX2-5 MYH7 MYBPC3
40	heart valve disease	31.2	TTN TNNT2 NKX2-5 MYH7 MYBPC3
41	emery-dreifuss muscular dystrophy	31.2	TTN LMNA LDB3
42	cardiomyopathy, familial hypertrophic, 4	31.1	TTN TPM1 MYH7 MYBPC3
43	myofibrillar myopathy	31.1	TTN MYH7 MYBPC3 LMNA LDB3
44	chromosome 1p36 deletion syndrome	31.1	PRDM16 NKX2-5 MYBPC3
45	endomyocardial fibrosis	31.1	MYH7 MYBPC3 ACTC1
46	cardiomyopathy, dilated, 1g	31.1	TTN-AS1 TTN LMNA
47	muscular dystrophy, limb-girdle, autosomal recessive 10	31.0	TTN-AS1 TTN
48	rasopathy	31.0	TTN TPM1 TNNT2 SCN5A PKP2 NKX2-5
49	orthostatic intolerance	31.0	TTN-AS1 TTN NKX2-5
50	familial woolly hair syndrome	31.0	TTN SCN5A PKP2 LMNA

Graphical network of the top 20 diseases related to Left Ventricular Noncompaction:

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Symptoms & Phenotypes for Left Ventricular Noncompaction

MGI Mouse Phenotypes related to Left Ventricular Noncompaction:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.16	ACTC1 LAMP2 LDB3 LMNA MIB1 MIPEP
2	muscle	MP:0005369	10.13	ACTC1 DTNA LAMP2 LDB3 LMNA MYBPC3
3	normal	MP:0002873	10.07	ACTC1 LMNA MIB1 MYH7 NKX2-5 PRDM16
4	growth/size/body region	MP:0005378	10	ACTC1 DTNA LAMP2 LDB3 LMNA MIB1
5	cardiovascular system	MP:0005385	9.86	ACTC1 DTNA LAMP2 LDB3 LMNA MIB1
6	mortality/aging	MP:0010768	9.53	ACTC1 DTNA LAMP2 LDB3 LMNA MIB1

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Drugs & Therapeutics for Left Ventricular Noncompaction

Interventional clinical trials:

(show all 14)

#	Name	Status	NCT ID
1	Risk Stratification in Children and Adolescents With Primary Cardiomyopathy	Unknown status	NCT03572569
2	DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK)	Unknown status	NCT02187263
3	Metabolomic Study of Patients With Cardiomyopathy in China	Unknown status	NCT03061994
4	An Integrative-omics Study to Identify New Biomarkers of Cardiomyopathy Patients in China	Unknown status	NCT03076580
5	Prognosis of Isolated Left Ventricular Non-compaction in Adults	Unknown status	NCT02885363
6	Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction	Completed	NCT01470014
7	Value of Different Myocardial Parameters to Differentiate Left Ventricular Noncompaction Cardiomyopathy From Other Cardiomyopathies and Healthy Controls by Cardiac Magnetic Resonance	Completed	NCT01481298
8	Increased Left Ventricular Trabeculation in Athletes - a Marker of Left Ventricular Non-compaction or a Physiological Epiphenomenon of Increased Cardiac Preload?	Completed	NCT02568072
9	Cardiac Magnetic Resonance Features and Outcomes of Patients With Non-Compaction Cardiomyopathy - a Retrospective Follow-up From Pakistan	Completed	NCT05281315
10	TranslatiOnal Registry for CardiomyopatHies (TORCH) - Plus as Part of the German Centre for Cardiovascular Research (DZHK)	Recruiting	NCT04265040
11	Pediatric Cardiomyopathy Mutation Analysis	Recruiting	NCT02432092
12	International Consortium for Multimodality Phenotyping in Adults With Non-compaction	Recruiting	NCT04424030
13	Analysis of Cardiac Biomarkers, Electrocardiograms and Cardio-pulmonary Exercise Test (CPET) Results in Children With Dilated (DCM), Hypertrophic (HCM) and Left-ventricle Non-compaction (LVNC) Cardiomyopathies	Active, not recruiting	NCT04316923
14	The Genetics of Cardiomyopathy and Heart Failure	Withdrawn	NCT00703443

Search NIH Clinical Center for Left Ventricular Noncompaction

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Genetic Tests for Left Ventricular Noncompaction

Genetic tests related to Left Ventricular Noncompaction:

#	Genetic test	Affiliating Genes
1	Left Ventricular Noncompaction ²⁸

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Anatomical Context for Left Ventricular Noncompaction

Organs/tissues related to Left Ventricular Noncompaction:

MalaCards : Heart, Kidney, Skeletal Muscle, Cardiac Myocytes, Smooth Muscle, Bone Marrow, Thyroid

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Publications for Left Ventricular Noncompaction

Articles related to Left Ventricular Noncompaction:

(show top 50) (show all 2137)

#	Title	Authors	PMID	Year
1	MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death. ⁶² ⁵	Eldomery MK...Sutton VR	27799064	2016
2	A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction. ⁶² ⁵	Tian T...Song L	24691700	2015
3	Familial ebstein anomaly, left ventricular hypertrabeculation, and ventricular septal defect associated with a MYH7 mutation. ⁶² ⁵	Bettinelli AL...Niyazov DM	23956225	2013
4	Interpreting secondary cardiac disease variants in an exome cohort. ⁶² ⁵	Ng D...NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program	23861362	2013
5	Prenatal ultrasound diagnosis of MYH7 non-compaction cardiomyopathy. ⁶² ⁵	Hoedemaekers YM...Majoor-Krakauer DF	22859017	2013
6	Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype. ⁶² ⁵	Probst S...Klaassen S	21551322	2011
7	Mutations in the sarcomere gene MYH7 in Ebstein anomaly. ⁶² ⁵	Postma AV...Klaassen S	21127202	2011
8	Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation. ⁶² ⁵	Dellefave LM...McNally EM	20031619	2009
9	Mutations in sarcomere protein genes in left ventricular noncompaction. ⁶² ⁵	Klaassen S...Thierfelder L	18506004	2008
10	Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy. ⁵	Lieberwirth JK...Abou Jamra R	33547425	2021
11	Genetic testing for dilated cardiomyopathy in clinical practice. ⁵	Lakdawala NK...Ho CY	22464770	2012
12	Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. ⁵	Jordan DM...Sunyaev SR	21310275	2011
13	Array-based resequencing assay for mutations causing hypertrophic cardiomyopathy. ⁵	Waldmuller S...Scheffold T	18258667	2008
14	Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. ⁵	Budde BS...Scheffold T	18159245	2007
15	Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). ⁵	Nishino I...Hirano M	10972294	2000
16	The Electrocardiogram in the Diagnosis and Management of Patients With Left Ventricular Non-Compaction. ⁶²	Sanna GD...Finocchiaro G	36227527	2022
17	Left ventricular noncompaction: a disease or a phenotypic trait? ⁶²	Casas G...Ferreira-Gonzalez I	35820566	2022
18	Prognostic value of cardiac magnetic resonance imaging parameters in left ventricular noncompaction with left ventricular dysfunction. ⁶²	Bai W...Guo Y	36474142	2022
19	Echocardiography features of non-compaction cardiomyopathy. ⁶²	Molina Lobo R...Hermosa Gelbard C	36088258	2022
20	Coronary conductance in the normal development of sheep during the perinatal period. ⁶²	Hagen MW...Jonker SS	36461657	2022
21	Genetic Testing as a Guide for Treatment in Dilated Cardiomyopathies. ⁶²	Garcia-Hernandez S...Iglesias LM	35994197	2022
22	Genetic and phenotypic spectrum in the NONO-associated syndromic disorder. ⁶²	Roessler F...Strehlow V	36426740	2022
23	Left ventricular non-compaction in paediatrics: a novel semi-automated imaging technique bridging imaging findings and clinical outcomes. ⁶²	Tadros HJ...Wilkinson JC	36441164	2022
24	Left ventricular non-compaction cardiomyopathy: a rare cause of stroke. ⁶²	Mishra A...Kalita J	36404113	2022
25	Renal dysfunction and outcome in left ventricular non-compaction. ⁶²	Erhart L...Stampfli SF	36385602	2022
26	Peripartum anesthetic management in patients with left ventricular noncompaction: a case series and review of the literature. ⁶²	Clark KJ...Sharpe EE	35905687	2022
27	Biventricular Assist Device Support for Intractable Arrhythmias From Histiocytoid Cardiomyopathy. ⁶²	Magnetta DA...Joong A	35439193	2022
28	MRI-derived cardiac washout is slowed in the left ventricle and associated with left ventricular non-compaction in young patients with cryptogenic ischemic stroke. ⁶²	Lehmonen L...Jarvinen V	36434329	2022
29	The outcome of peripartum cardiomyopathy patients-single center experience. ⁶²	Demir E...Nalbantgil S	36447302	2022
30	Dilated Cardiomyopathy in Children: Early Detection and Treatment. ⁶²	Mallavarapu A...Taksande A	36475220	2022
31	[Cardiac MRI in nonischemic cardiomyopathies]. ⁶²	Lucke C...Gutberlet M	36129478	2022
32	Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. ⁶²	Siguero-Alvarez M...de la Pompa JL	36325906	2022
33	Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. ⁶²	Bazoukis G...Baranchuk A	35776368	2022
34	Genetic Basis of Childhood Cardiomyopathy. ⁶²	Bagnall RD...Semsarian C	36252119	2022
35	Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation. ⁶²	Zhang J...Wang T	36221081	2022
36	An Unusual Presentation of Left Ventricular Non-compaction Cardiomyopathy in a Female Patient With Sudden Cardiac Arrest: A Case Report. ⁶²	Tasha T...Sonani N	36451648	2022
37	Isolated Left Ventricular Noncompaction Presenting With Heart Failure With Reduced Ejection Fraction and Intrahospital Cardiac Arrest: A Case Report and Literature Review. ⁶²	Goncalves FMF...Cotter J	36415422	2022
38	Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study. ⁶²	Huang W...Ye L	36292149	2022
39	The use of 2-D speckle tracking echocardiography in assessing adolescent athletes with left ventricular hypertrabeculation meeting the criteria for left ventricular non-compaction cardiomyopathy. ⁶²	Dorobantu DM...Pieles GE	36216087	2022
40	Left ventricular non-compaction cardiomyopathy: restrictive subtype with MYH7 gene mutation. ⁶²	Oztarhan K...Ucar O	36217801	2022
41	Left ventricular non-compaction with normal myocardial perfusion. ⁶²	Al-Makhamreh H...Juweid M	33386538	2022
42	Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathy. ⁶²	Koopmann TT...Maroofian R	36253531	2022
43	Biventricular biaxial mechanical testing and constitutive modelling of fetal porcine myocardium passive stiffness. ⁶²	Ren M...Yap CH	35932646	2022
44	Effects of elevated bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy, a retrospective study from a neonatal perspective. ⁶²	Wang J...Shi W	36044978	2022
45	Aortic root replacement for aortic root aneurysm with severe aortic regurgitation and incidentally detected left ventricular hyper-trabeculation/noncompaction. ⁶²	Boldyrev S...Sef D	36050986	2022
46	Characteristics and long-term survival of patients with left ventricular non-compaction cardiomyopathy. ⁶²	Demir E...Nalbantgil S	36111517	2022
47	Biventricular non-compaction cardiomyopathy: Rare disease and far rarer case. ⁶²	Warchol I...Plewka M	36082796	2022
48	Spatial uniformity of action potentials indicates base-to-apex depolarization and repolarization of rainbow trout (Oncorhynchus mykiss) ventricle. ⁶²	Badr A...Vornanen M	35950359	2022
49	Prognostic factors associated with left ventricular non-compaction: A PRISMA-compliant meta-analysis. ⁶²	Yang ZG...Wang L	36123904	2022
50	Left Ventricular Non-compaction in a 40-Year-Old Male With Congenital Hydrocephalus. ⁶²	Ritchie C...Albagoush S	36312646	2022

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Genes for Left Ventricular Noncompaction

Genes related to Left Ventricular Noncompaction (20 elite genes):

(show top 50) (show all 126)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MYH7	Myosin Heavy Chain 7	Protein Coding	791.8	Pathogenic ⁵ Causative germline mutation ⁵⁸ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	18159245 18258667 18506004 (more) 20031619 21310275 21551322 22464770 22859017 23861362 24691700 21127202 23956225 25415959
2	MYBPC3	Myosin Binding Protein C3	Protein Coding	466.12	Pathogenic ⁵ Likely pathogenic ⁵ Candidate gene tested ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	20031619 21551322
3	LMNA	Lamin A/C	Protein Coding	456.93	Pathogenic ⁵ Likely pathogenic ⁵ Susceptibility factor ⁵⁸ DISEASES inferred ¹⁴
4	TTN	Titin	Protein Coding	407.48	Pathogenic ⁵ DISEASES inferred ¹⁴
5	NKX2-5	NK2 Homeobox 5	Protein Coding	407	Pathogenic ⁵ DISEASES inferred ¹⁴
6	LAMP2	Lysosomal Associated Membrane Protein 2	Protein Coding	405.69	Pathogenic ⁵ DISEASES inferred ¹⁴	10972294
7	MIPEP	Mitochondrial Intermediate Peptidase	Protein Coding	405.6	Pathogenic ⁵ DISEASES inferred ¹⁴	27799064
8	TTN-AS1	TTN Antisense RNA 1	RNA Gene	400	Pathogenic ⁵
9	TPM1	Tropomyosin 1	Protein Coding	365.19	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	21551322
10	TNNT2	Troponin T2, Cardiac Type	Protein Coding	364.93	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	20083571
11	PKP2	Plakophilin 2	Protein Coding	357.15	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴	27030002
12	PRDM16	PR/SET Domain 16	Protein Coding	356.24	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴	23768516
13	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	355.66	Causative germline mutation (loss of function) ⁵⁸ DISEASES inferred ¹⁴	23314057
14	MYH7B	Myosin Heavy Chain 7B	Protein Coding	355.31	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴	23800289
15	DTNA	Dystrobrevin Alpha	Protein Coding	75.77	Likely pathogenic ⁵ Candidate gene tested ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)	11238270
16	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	65.69	Likely pathogenic ⁵ Susceptibility factor ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	18506004
17	LVNC2	Noncompaction Of Left Ventricular Myocardium, Familial Isolated, Autosomal Dominant 2	Genetic Locus	50	MalaCards inferred ³⁹
18	PLEKHM2	Pleckstrin Homology And RUN Domain Containing M2	Protein Coding	48.4	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)	26464484
19	LDB3	LIM Domain Binding 3	Protein Coding	32.88	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁴
20	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	29.65	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁴	28013292
21	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	32.1	Risk factor ⁵ DISEASES inferred ¹⁴
22	TAFAZZIN	Tafazzin, Phospholipid-Lysophospholipid Transacylase	Protein Coding	26.1	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
23	GJD2-DT	GJD2 Divergent Transcript	RNA Gene	25	Likely pathogenic ⁵
24	LOC110121269	VISTA Enhancer Hs2177	Functional Element	25	Risk factor ⁵
25	SLC30A5	Solute Carrier Family 30 Member 5	Protein Coding	25	Likely pathogenic ⁵	33547425
26	MYH6	Myosin Heavy Chain 6	Protein Coding	8.14	DISEASES inferred ¹⁴
27	RBM20	RNA Binding Motif Protein 20	Protein Coding	7.3	DISEASES inferred ¹⁴
28	HCN4	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4	Protein Coding	7.16	DISEASES inferred ¹⁴
29	ACTN2	Actinin Alpha 2	Protein Coding	7.09	DISEASES inferred ¹⁴
30	RYR2	Ryanodine Receptor 2	Protein Coding	7.09	DISEASES inferred ¹⁴
31	TBX20	T-Box Transcription Factor 20	Protein Coding	7.08	DISEASES inferred ¹⁴
32	CSRP3	Cysteine And Glycine Rich Protein 3	Protein Coding	6.69	DISEASES inferred ¹⁴
33	FLNC	Filamin C	Protein Coding	6.6	DISEASES inferred ¹⁴
34	DCAF8	DDB1 And CUL4 Associated Factor 8	Protein Coding	6.59	DISEASES inferred ¹⁴ ¹⁴
35	MYL3	Myosin Light Chain 3	Protein Coding	6.59	DISEASES inferred ¹⁴
36	TNNI3	Troponin I3, Cardiac Type	Protein Coding	6.54	DISEASES inferred ¹⁴
37	MYL2	Myosin Light Chain 2	Protein Coding	6.41	DISEASES inferred ¹⁴
38	CT45A10	Cancer/Testis Antigen Family 45 Member A10	Protein Coding	6.41	DISEASES inferred ¹⁴ ¹⁴
39	DSG2	Desmoglein 2	Protein Coding	6.36	DISEASES inferred ¹⁴
40	CASQ2	Calsequestrin 2	Protein Coding	6.32	DISEASES inferred ¹⁴
41	TBX5	T-Box Transcription Factor 5	Protein Coding	6.29	DISEASES inferred ¹⁴
42	TCAP	Titin-Cap	Protein Coding	6.27	DISEASES inferred ¹⁴
43	DSP	Desmoplakin	Protein Coding	6.24	DISEASES inferred ¹⁴
44	DSC2	Desmocollin 2	Protein Coding	6.23	DISEASES inferred ¹⁴
45	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	6.23	DISEASES inferred ¹⁴
46	OBSCN	Obscurin, Cytoskeletal Calmodulin And Titin-Interacting RhoGEF	Protein Coding	6.22	DISEASES inferred ¹⁴
47	MYPN	Myopalladin	Protein Coding	6.22	DISEASES inferred ¹⁴
48	TMEM43	Transmembrane Protein 43	Protein Coding	6.14	DISEASES inferred ¹⁴
49	MIR29A	MicroRNA 29a	RNA Gene	6.11	DISEASES inferred ¹⁴ ¹⁴
50	JUP	Junction Plakoglobin	Protein Coding	6	DISEASES inferred ¹⁴

Sources

Variations for Left Ventricular Noncompaction

ClinVar genetic disease variations for Left Ventricular Noncompaction:

⁵ (show top 50) (show all 53)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	MIPEP	NM_005932.4(MIPEP):c.1804G>T (p.Glu602Ter)	SNV	Pathogenic	208631	rs114638163	GRCh37: 13:24380133-24380133 GRCh38: 13:23805994-23805994
2	overlap with 8 genes	GRCh37/hg19 13q12.12(chr13:23519916-24941516)x1	CN LOSS	Pathogenic	208634		GRCh37: 13:23519916-24941516 GRCh38:
3	LAMP2	NM_002294.3(LAMP2):c.668dup (p.Tyr223Ter)	DUP	Pathogenic	1065183		GRCh37: X:119581768-119581769 GRCh38: X:120447913-120447914
4	NKX2-5	NM_004387.4(NKX2-5):c.711C>A (p.Tyr237Ter)	SNV	Pathogenic	523473	rs1554093433	GRCh37: 5:172659836-172659836 GRCh38: 5:173232833-173232833
5	TTN	NM_001267550.2(TTN):c.20836+1G>A	SNV	Pathogenic	523428	rs1553915256	GRCh37: 2:179590094-179590094 GRCh38: 2:178725367-178725367
6	TTN-AS1, TTN	NM_001267550.2(TTN):c.47961del (p.Gly15988fs)	DEL	Pathogenic	523430	rs1553707780	GRCh37: 2:179481655-179481655 GRCh38: 2:178616928-178616928
7	MYBPC3	NM_000256.3(MYBPC3):c.1038_1042dup (p.Met348fs)	DUP	Pathogenic	177698	rs730880336	GRCh37: 11:47367806-47367810 GRCh38: 11:47346254-47346255
8	MYBPC3	NM_000256.3(MYBPC3):c.1404del (p.Gln469fs)	DEL	Pathogenic	254153	rs886037900	GRCh37: 11:47364434-47364434 GRCh38: 11:47342883-47342883
9	MYH7	NM_000257.4(MYH7):c.732+1G>A	SNV	Pathogenic	14127	rs730880850	GRCh37: 14:23900793-23900793 GRCh38: 14:23431584-23431584
10	MYH7	NM_000257.4(MYH7):c.1106G>A (p.Arg369Gln)	SNV	Pathogenic	42822	rs397516089	GRCh37: 14:23899016-23899016 GRCh38: 14:23429807-23429807
11	MYH7	NM_000257.4(MYH7):c.1157A>G (p.Tyr386Cys)	SNV	Pathogenic	164378	rs727503269	GRCh37: 14:23898538-23898538 GRCh38: 14:23429329-23429329
12	MYH7	NM_000257.4(MYH7):c.842G>C (p.Arg281Thr)	SNV	Pathogenic	181327	rs730880856	GRCh37: 14:23900163-23900163 GRCh38: 14:23430954-23430954
13	MYBPC3	NM_000256.3(MYBPC3):c.3190+5G>A	SNV	Pathogenic	155808	rs587782958	GRCh37: 11:47355103-47355103 GRCh38: 11:47333552-47333552
14	MYBPC3	NM_000256.3(MYBPC3):c.3776del (p.Gln1259fs)	DEL	Pathogenic	164021	rs727503166	GRCh37: 11:47353661-47353661 GRCh38: 11:47332110-47332110
15	LMNA	NM_170707.4(LMNA):c.1003C>T (p.Arg335Trp)	SNV	Pathogenic	36473	rs386134243	GRCh37: 1:156105758-156105758 GRCh38: 1:156135967-156135967
16	LOC110121269, SCN5A	NM_000335.5(SCN5A):c.3305C>A (p.Ser1102Tyr)	SNV	Risk Factor	9393	rs7626962	GRCh37: 3:38620907-38620907 GRCh38: 3:38579416-38579416
17	MYBPC3	NM_000256.3(MYBPC3):c.1000G>A (p.Glu334Lys)	SNV	Likely Pathogenic	177902	rs573916965	GRCh37: 11:47367848-47367848 GRCh38: 11:47346297-47346297
18	LMNA	NM_170707.4(LMNA):c.1567G>A (p.Gly523Arg)	SNV	Likely Pathogenic	48045	rs201583907	GRCh37: 1:156106982-156106982 GRCh38: 1:156137191-156137191
19	SLC30A5	NM_022902.5(SLC30A5):c.832_836del (p.Ile278fs)	DEL	Likely Pathogenic	976212	rs1746359403	GRCh37: 5:68411799-68411803 GRCh38: 5:69115972-69115976
20	MYH7	NM_000257.4(MYH7):c.3658_3660del (p.Glu1220del)	DEL	Likely Pathogenic	42968	rs397516190	GRCh37: 14:23889120-23889122 GRCh38: 14:23419911-23419913
21	MYH7	NM_000257.4(MYH7):c.3748C>T (p.Arg1250Trp)	SNV	Likely Pathogenic	164299	rs727503249	GRCh37: 14:23888797-23888797 GRCh38: 14:23419588-23419588
22	GJD2-DT, ACTC1	NM_005159.5(ACTC1):c.806T>C (p.Ile269Thr)	SNV	Likely Pathogenic	45190	rs397517071	GRCh37: 15:35084293-35084293 GRCh38: 15:34792092-34792092
23	MYH7	NM_000257.4(MYH7):c.732+2T>G	SNV	Likely Pathogenic	454395	rs1555338658	GRCh37: 14:23900792-23900792 GRCh38: 14:23431583-23431583
24	MYH7	NM_000257.4(MYH7):c.1000-1G>A	SNV	Likely Pathogenic	637005	rs113392527	GRCh37: 14:23899123-23899123 GRCh38: 14:23429914-23429914
25	SLC30A5	NM_022902.5(SLC30A5):c.1981_1982del (p.His661fs)	DEL	Likely Pathogenic	988899	rs1746589361	GRCh37: 5:68419234-68419235 GRCh38: 5:69123407-69123408
26	DTNA	NM_001386795.1(DTNA):c.177A>G (p.Ile59Met)	SNV	Likely Pathogenic	374197	rs1057518968	GRCh37: 18:32374029-32374029 GRCh38: 18:34794065-34794065
27	LDB3	NM_007078.3(LDB3):c.1351C>G (p.Pro451Ala)	SNV	Uncertain Significance	967764	rs1589674758	GRCh37: 10:88476203-88476203 GRCh38: 10:86716446-86716446
28	MYH6	NM_002471.4(MYH6):c.3383G>A (p.Arg1128His)	SNV	Uncertain Significance	44482	rs376002621	GRCh37: 14:23859615-23859615 GRCh38: 14:23390406-23390406
29	DSP	NM_004415.4(DSP):c.2894T>C (p.Leu965Pro)	SNV	Uncertain Significance	642389	rs1581813405	GRCh37: 6:7578028-7578028 GRCh38: 6:7577795-7577795
30	PKP2	NM_001005242.3(PKP2):c.1878C>A (p.Asn626Lys)	SNV	Uncertain Significance	684846	rs769943903	GRCh37: 12:32974425-32974425 GRCh38: 12:32821491-32821491
31	MYH7	NM_000257.4(MYH7):c.803T>G (p.Leu268Arg)	SNV	Uncertain Significance	684854	rs1555338582	GRCh37: 14:23900202-23900202 GRCh38: 14:23430993-23430993
32	MIPEP	NM_005932.4(MIPEP):c.916C>T (p.Leu306Phe)	SNV	Uncertain Significance	208630	rs143912947	GRCh37: 13:24443458-24443458 GRCh38: 13:23869319-23869319
33	MIPEP	NM_005932.4(MIPEP):c.212T>A (p.Leu71Gln)	SNV	Uncertain Significance	208629	rs1057518740	GRCh37: 13:24460623-24460623 GRCh38: 13:23886484-23886484
34	MIPEP	NM_005932.4(MIPEP):c.1027A>G (p.Lys343Glu)	SNV	Uncertain Significance	208632	rs1057518741	GRCh37: 13:24436467-24436467 GRCh38: 13:23862328-23862328
35	MIPEP	NM_005932.4(MIPEP):c.1745T>G (p.Leu582Arg)	SNV	Uncertain Significance	208628	rs1057518739	GRCh37: 13:24380192-24380192 GRCh38: 13:23806053-23806053
36	TAFAZZIN	NM_000116.5(TAFAZZIN):c.680dup (p.Tyr227Ter)	DUP	Uncertain Significance	446166	rs1557194203	GRCh37: X:153648583-153648584 GRCh38: X:154420244-154420245
37	MIPEP	NM_005932.4(MIPEP):c.1534C>G (p.His512Asp)	SNV	Uncertain Significance	208633	rs779598020	GRCh37: 13:24411700-24411700 GRCh38: 13:23837561-23837561
38	RYR2	NM_001035.3(RYR2):c.13412G>C (p.Gly4471Ala)	SNV	Uncertain Significance	488158	rs1553325274	GRCh37: 1:237951371-237951371 GRCh38: 1:237788071-237788071
39	RYR2	NM_001035.3(RYR2):c.13291G>A (p.Glu4431Lys)	SNV	Uncertain Significance	165128	rs571985775	GRCh37: 1:237949299-237949299 GRCh38: 1:237785999-237785999
40	ANKRD1	NM_014391.3(ANKRD1):c.806G>A (p.Arg269Gln)	SNV	Uncertain Significance	520516	rs367609929	GRCh37: 10:92675343-92675343 GRCh38: 10:90915586-90915586
41	JUP	NM_002230.4(JUP):c.2105G>A (p.Arg702His)	SNV	Uncertain Significance	178849	rs200690479	GRCh37: 17:39912129-39912129 GRCh38: 17:41755877-41755877
42	PKP2	NM_001005242.3(PKP2):c.2302G>A (p.Asp768Asn)	SNV	Uncertain Significance	403313	rs200947767	GRCh37: 12:32949098-32949098 GRCh38: 12:32796164-32796164
43	BAG3	NM_004281.4(BAG3):c.653G>A (p.Arg218Gln)	SNV	Uncertain Significance	179009	rs201638005	GRCh37: 10:121431912-121431912 GRCh38: 10:119672400-119672400
44	TGFB3	NM_003239.5(TGFB3):c.293C>T (p.Ser98Leu)	SNV	Uncertain Significance	192131	rs142047577	GRCh37: 14:76446944-76446944 GRCh38: 14:75980601-75980601
45	TPM1	NM_001018005.2(TPM1):c.797A>G (p.Lys266Arg)	SNV	Uncertain Significance	178148	rs371934474	GRCh37: 15:63356287-63356287 GRCh38: 15:63064088-63064088
46	JUP	NM_002230.4(JUP):c.1507G>A (p.Gly503Ser)	SNV	Uncertain Significance	468745	rs376051686	GRCh37: 17:39915113-39915113 GRCh38: 17:41758861-41758861
47	MYBPC3	NM_000256.3(MYBPC3):c.2217G>A (p.Glu739=)	SNV	Uncertain Significance	407331	rs786204348	GRCh37: 11:47360162-47360162 GRCh38: 11:47338611-47338611
48	MYH7	NM_000257.4(MYH7):c.2945T>C (p.Met982Thr)	SNV	Uncertain Significance	42941	rs145532615	GRCh37: 14:23892910-23892910 GRCh38: 14:23423701-23423701
49	MYH6	NM_002471.4(MYH6):c.3413G>A (p.Arg1138His)	SNV	Uncertain Significance	470523	rs745801044	GRCh37: 14:23859585-23859585 GRCh38: 14:23390376-23390376
50	TTN-AS1, TTN	NM_001267550.2(TTN):c.92151T>C (p.Tyr30717=)	SNV	Uncertain Significance	511503	rs182422055	GRCh37: 2:179414298-179414298 GRCh38: 2:178549571-178549571

Sources

Expression for Left Ventricular Noncompaction

Search GEO for disease gene expression data for Left Ventricular Noncompaction.

Sources

Pathways for Left Ventricular Noncompaction

Pathways related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁶ Show member pathways Classical Kir channels ⁶⁶ Ion homeostasis ⁶⁶ Ion transport by P-type ATPases ⁶⁶ Muscle contraction ⁶⁶ Phase 1 - inactivation of fast Na+ channels ⁶⁶ Phase 2 - plateau phase ⁶⁶ Phase 3 - rapid repolarisation ⁶⁶ Phase 4 - resting membrane potential ⁶⁶ Physiological factors ⁶⁶ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁶ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁶ Tandem pore domain potassium channels ⁶⁶ TWIK related potassium channel (TREK) ⁶⁶ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁶ TWIK-related spinal cord K+ channel (TRESK) ⁶⁶ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁶	12.23	TTN TPM1 TNNT2 SCN5A NKX2-5 MYBPC3
2	Cytoskeletal Signaling ³	12.16	TPM1 TNNT2 LMNA ACTC1
3	Cardiac progenitor differentiation ⁷⁴	11.18	TNNT2 SCN5A NKX2-5 ACTC1
4	Striated muscle contraction pathway ⁷⁴ Show member pathways Striated Muscle Contraction ⁶⁶	10.89	TTN TPM1 TNNT2 MYBPC3 ACTC1
5	Cardiomyocyte Differentiation through BMP Receptors ⁶⁴	10.78	NKX2-5 MYH7B MYH7
6	HOP Signaling ⁶⁴	10.1	NKX2-5 ACTC1

Sources

GO Terms for Left Ventricular Noncompaction

Cellular components related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Z disc	GO:0030018	9.86	TTN SCN5A MYH7 LDB3
2	stress fiber	GO:0001725	9.85	TPM1 MYH7 LDB3
3	myosin filament	GO:0032982	9.55	MYH7B MYH7 MYBPC3
4	striated muscle thin filament	GO:0005865	9.5	TTN TNNT2
5	cardiac myofibril	GO:0097512	9.35	TNNT2 MYH7B MYBPC3
6	sarcomere	GO:0030017	9.32	TPM1 TNNT2 MYH7 MYBPC3 ACTC1

Biological processes related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:0006936	10.03	MYH7 TNNT2 TPM1 TTN
2	positive regulation of ATP-dependent activity	GO:0032781	9.93	TPM1 TNNT2 MYBPC3
3	striated muscle contraction	GO:0006941	9.88	TTN MYH7 DTNA
4	positive regulation of sodium ion transport	GO:0010765	9.85	SCN5A PKP2 NKX2-5
5	sarcomere organization	GO:0045214	9.85	TTN TPM1 TNNT2 MYH7 LDB3
6	cardiac myofibril assembly	GO:0055003	9.81	TTN ACTC1
7	ventricular cardiac muscle cell development	GO:0055015	9.8	NKX2-5 LMNA
8	cardiac muscle tissue morphogenesis	GO:0055008	9.8	ACTC1 NKX2-5 TTN
9	skeletal muscle thin filament assembly	GO:0030240	9.78	TTN ACTC1
10	muscle filament sliding	GO:0030049	9.73	TPM1 TNNT2 MYH7
11	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.65	MYBPC3 MYH7 PKP2 TNNT2 TPM1
12	cardiac muscle contraction	GO:0060048	9.47	TTN TPM1 TNNT2 SCN5A NKX2-5 MYH7

Molecular functions related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	actin binding	GO:0003779	9.65	TPM1 TNNT2 MYH7B MYH7 MYBPC3 LDB3
2	structural constituent of muscle	GO:0008307	9.63	TTN TPM1 MYBPC3
3	microfilament motor activity	GO:0000146	9.17	TNNT2 MYH7B MYH7 ACTC1

Sources

Sources for Left Ventricular Noncompaction

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

LVHT MCID: LFT003 MIFTS: 55	Left Ventricular Noncompaction (LVHT) Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Genetic diseases, Muscle diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Expand all tables

Left Ventricular Noncompaction (LVHT)

Aliases & Classifications for Left Ventricular Noncompaction

MalaCards integrated aliases for Left Ventricular Noncompaction:

Characteristics:

Inheritance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Left Ventricular Noncompaction

Related Diseases for Left Ventricular Noncompaction

Diseases in the Left Ventricular Noncompaction family:

Diseases related to Left Ventricular Noncompaction via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Left Ventricular Noncompaction:

Symptoms & Phenotypes for Left Ventricular Noncompaction

MGI Mouse Phenotypes related to Left Ventricular Noncompaction:

Drugs & Therapeutics for Left Ventricular Noncompaction

Interventional clinical trials:

Genetic Tests for Left Ventricular Noncompaction

Genetic tests related to Left Ventricular Noncompaction:

Anatomical Context for Left Ventricular Noncompaction

Organs/tissues related to Left Ventricular Noncompaction:

Publications for Left Ventricular Noncompaction

Articles related to Left Ventricular Noncompaction:

Genes for Left Ventricular Noncompaction

Genes related to Left Ventricular Noncompaction (20 elite genes):

Variations for Left Ventricular Noncompaction

ClinVar genetic disease variations for Left Ventricular Noncompaction:

Expression for Left Ventricular Noncompaction

Pathways for Left Ventricular Noncompaction

Pathways related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

GO Terms for Left Ventricular Noncompaction

Cellular components related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Biological processes related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Molecular functions related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Sources for Left Ventricular Noncompaction