Left Ventricular Noncompaction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LVHT MCID: LFT003 MIFTS: 57	Left Ventricular Noncompaction (LVHT) Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Genetic diseases, Muscle diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Left Ventricular Noncompaction

MalaCards integrated aliases for Left Ventricular Noncompaction:

Name: Left Ventricular Noncompaction ¹² ²⁰ ⁴³ ⁵⁸ ³⁶ ²⁹ ⁶ ¹⁵ ⁷¹

Left Ventricular Hypertrabeculation ¹² ²⁰ ⁴³ ⁵⁸

Noncompaction Cardiomyopathy ⁴³ ⁶ ⁷¹

Spongy Myocardium ²⁰ ⁴³ ⁵⁸

Left Ventricular Myocardial Noncompaction Cardiomyopathy ⁴³ ⁷¹

Isolated Noncompaction of the Ventricular Myocardium ⁴³ ¹⁷

Lvnc ²⁰ ⁵⁸

Non-Compaction of the Left Ventricular Myocardium ⁴³

Left Ventricular Non-Compaction ⁴³

Ventricular Noncompaction, Left ³⁹

Non-Compaction Cardiomyopathy ¹⁷

Hypertrabeculation Syndrome ⁴³

Honeycomb Myocardium ⁴³

Fetal Myocardium ⁴³

Lvht ⁴³

Characteristics:

Orphanet epidemiological data:

⁵⁸

left ventricular noncompaction
Inheritance: Autosomal dominant,Mitochondrial inheritance,X-linked recessive; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Fetal diseases
Anatomical: Cardiovascular diseases Muscle diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Other forms of heart disease

Cardiomyopathy

Other cardiomyopathies

External Ids:

Disease Ontology ¹² DOID:0060480

KEGG ³⁶ H01216

ICD10 via Orphanet ³³ I42.8

UMLS via Orphanet ⁷² C1960469

Orphanet ⁵⁸ ORPHA54260

EFO ¹⁷ EFO_0004686 EFO_1001802

UMLS ⁷¹ C1839832 C1960469 C3164472

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Summaries for Left Ventricular Noncompaction

MedlinePlus Genetics : ⁴³ Left ventricular noncompaction is a heart (cardiac) muscle disorder that occurs when the lower left chamber of the heart (left ventricle), which helps the heart pump blood, does not develop correctly. Instead of the muscle being smooth and firm, the cardiac muscle in the left ventricle is thick and appears spongy. The abnormal cardiac muscle is weak and has an impaired ability to pump blood because it either cannot completely contract or it cannot completely relax. For the heart to pump blood normally, cardiac muscle must contract and relax fully.Some individuals with left ventricular noncompaction experience no symptoms at all; others have heart problems that can include sudden cardiac death. Additional signs and symptoms include abnormal blood clots, irregular heart rhythm (arrhythmia), a sensation of fluttering or pounding in the chest (palpitations), extreme fatigue during exercise (exercise intolerance), shortness of breath (dyspnea), fainting (syncope), swelling of the legs (lymphedema), and trouble laying down flat. Some affected individuals have features of other heart defects. Left ventricular noncompaction can be diagnosed at any age, from birth to late adulthood. Approximately two-thirds of individuals with left ventricular noncompaction develop heart failure.

MalaCards based summary : Left Ventricular Noncompaction, also known as left ventricular hypertrabeculation, is related to left ventricular noncompaction 1 and cardiomyopathy, dilated, 1e. An important gene associated with Left Ventricular Noncompaction is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Cardiac muscle contraction and Cardiac conduction. Affiliated tissues include heart, kidney and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : ¹² An intrinsic cardiomyopathy characterized by distinctive (spongy) morphological appearance of the LV myocardium.

GARD : ²⁰ Left ventricular noncompaction (LVNC) is a rare heart condition. In LVNC the inside wall of the heart is spongy or grooved, instead of smooth. Signs and symptoms of LVNC vary, but may cause life-threatening abnormal heart rhythms and weakness of the heart muscle. Treatments, such as blood thinning medication and defibrillators, are available to control these heart symptoms. In rare cases, heart transplantation is needed.

KEGG : ³⁶ Left ventricular noncompaction (LVNC) is a rare and potentially progressive cardiomyopathy, characterized by the presence of prominent trabeculations of the left ventricle, associated with progressive systolic failure, stroke and arrhythmia. It has been linked to mutations in several genes, including LIM domain binding protein 3 (ZASP), alpha-dystrobrevin (DTNA), and genes encoding the sarcomeric proteins, beta-myosin heavy chain (MYH7), alpha-cardiac actin (ACTC), and cardiac troponin T (TNNT2).

Wikipedia : ⁷⁴ Non-compaction cardiomyopathy (NCC), is a rare congenital cardiomyopathy that affects both children and... more...

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Related Diseases for Left Ventricular Noncompaction

Diseases in the Left Ventricular Noncompaction family:

Left Ventricular Noncompaction 1	Left Ventricular Noncompaction 2
Left Ventricular Noncompaction 7	Left Ventricular Noncompaction 8
Left Ventricular Noncompaction 10

Diseases related to Left Ventricular Noncompaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 440)

#	Related Disease	Score	Top Affiliating Genes
1	left ventricular noncompaction 1	33.7	PKP2 LDB3 DTNA
2	cardiomyopathy, dilated, 1e	33.7	TTN-AS1 TTN TPM1 RBM20 PKP2 MYH7
3	left ventricular noncompaction 10	33.4	MYBPC3 MADD
4	left ventricular noncompaction 2	33.3	TTN-AS1 TTN
5	barth syndrome	33.0	TTN TNNT2 MYH7 MYBPC3 LDB3 DTNA
6	atrial standstill 1	32.5	TTN-AS1 TTN TPM1 TNNT2 RBM20 PKP2
7	dilated cardiomyopathy	32.2	TTN-AS1 TTN TPM1 TNNT2 RBM20 PRDM16
8	cardiac conduction defect	32.0	MYH7 MYBPC3 LMNA
9	hypertrophic cardiomyopathy	32.0	TTN TPM1 TNNT2 RBM20 PKP2 NKX2-5
10	heart disease	31.9	TTN TPM1 TNNT2 PKP2 NKX2-5 MYH7
11	myopathy	31.9	TTN-AS1 TTN TPM1 TNNT2 MYH7B MYH7
12	heart septal defect	31.8	TNNT2 NKX2-5 ACTC1
13	mitral valve insufficiency	31.7	TTN TNNT2 MYH7 MYBPC3
14	left bundle branch hemiblock	31.7	TNNT2 PKP2 LMNA
15	cardiac arrest	31.6	TTN TNNT2 MYH7 MYBPC3
16	muscular dystrophy	31.6	TTN-AS1 TTN TNNT2 NKX2-5 MYH7 LMNA
17	atrial heart septal defect	31.5	TNNT2 NKX2-5 MYH7 ACTC1
18	atrioventricular block	31.5	TTN-AS1 TTN NKX2-5 MYH7 LMNA DES
19	endocardial fibroelastosis	31.5	MYH7 LDB3 DTNA
20	familial isolated dilated cardiomyopathy	31.4	TTN-AS1 TTN TPM1 TNNT2 RBM20 PRDM16
21	neuromuscular disease	31.4	TTN-AS1 TTN MYH7 LMNA LDB3 DES
22	lipoprotein quantitative trait locus	31.4	TTN TNNT2 PKP2 NKX2-5 MYH7 MYBPC3
23	ebstein anomaly	31.3	TPM1 TNNT2 NKX2-5 MYH7 MYBPC3 LDB3
24	long qt syndrome	31.3	TTN-AS1 TTN RBM20 PKP2 MYH7 MYBPC3
25	wolff-parkinson-white syndrome	31.3	TTN-AS1 TNNT2 NKX2-5 MYH7 MYBPC3 ACTC1
26	atrial fibrillation	31.3	TTN MYH7 MYBPC3 LMNA
27	emery-dreifuss muscular dystrophy	31.3	TTN LMNA LDB3 DES
28	muscular dystrophy, duchenne type	31.3	TTN TNNT2 DTNA DES
29	restrictive cardiomyopathy	31.3	TTN-AS1 TTN TPM1 TNNT2 PRDM16 MYH7
30	catecholaminergic polymorphic ventricular tachycardia	31.2	TPM1 TNNT2 PKP2 MYH7 MYBPC3 LMNA
31	tetralogy of fallot	31.2	TPM1 TNNT2 NKX2-5 ACTC1
32	brugada syndrome	31.2	TTN-AS1 TTN TPM1 TNNT2 RBM20 PKP2
33	arrhythmogenic right ventricular cardiomyopathy	31.1	TTN RBM20 PKP2 MYH7 LMNA LDB3
34	centronuclear myopathy	31.1	TTN-AS1 TTN DES
35	cardiomyopathy, familial hypertrophic, 4	31.0	TTN TPM1 TNNT2 MYH7 MYBPC3
36	dextrocardia	31.0	TNNT2 MYH7 ACTC1
37	ventricular fibrillation, paroxysmal familial, 1	31.0	TNNT2 NKX2-5
38	myofibrillar myopathy	31.0	TTN MYH7 LMNA LDB3 DES
39	cardiomyopathy, familial hypertrophic, 1	30.9	TTN TPM1 TNNT2 MYH7B MYH7 MYBPC3
40	rasopathy	30.9	TTN TNNT2 NKX2-5 MYH7 MYBPC3 ACTC1
41	aortic valve disease 2	30.9	TTN TNNT2 NKX2-5 MYH7 MYBPC3
42	noonan syndrome with multiple lentigines	30.9	TNNT2 NKX2-5 MYH7 MYBPC3
43	diastolic heart failure	30.9	TTN MYBPC3 MADD
44	multiminicore disease	30.8	TTN-AS1 TTN
45	holt-oram syndrome	30.8	NKX2-5 MYH7 LMNA
46	first-degree atrioventricular block	30.8	MYH7 LMNA
47	muscular dystrophy, congenital, lmna-related	30.8	TTN-AS1 TTN MYH7 LMNA LDB3 DTNA
48	patent foramen ovale	30.7	TNNT2 NKX2-5 ACTC1
49	cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction	11.8
50	left ventricular noncompaction 7	11.7

Graphical network of the top 20 diseases related to Left Ventricular Noncompaction:

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Symptoms & Phenotypes for Left Ventricular Noncompaction

MGI Mouse Phenotypes related to Left Ventricular Noncompaction:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.17	ACTC1 DES DTNA LDB3 LMNA MIB1
2	homeostasis/metabolism	MP:0005376	10.16	ACTC1 DES LDB3 LMNA MADD MIB1
3	mortality/aging	MP:0010768	10.03	ACTC1 DES DTNA LDB3 LMNA MADD
4	muscle	MP:0005369	9.73	ACTC1 DES DTNA LDB3 LMNA MYBPC3
5	normal	MP:0002873	9.23	ACTC1 LMNA MIB1 MYH7 NKX2-5 PRDM16

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Drugs & Therapeutics for Left Ventricular Noncompaction

Interventional clinical trials:

#	Name	Status	NCT ID
1	Prognosis of Isolated Left Ventricular Non-compaction in Adults	Unknown status	NCT02885363
2	Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction	Completed	NCT01470014
3	Value of Different Myocardial Parameters to Differentiate Left Ventricular Noncompaction Cardiomyopathy From Other Cardiomyopathies and Healthy Controls by Cardiac Magnetic Resonance	Completed	NCT01481298
4	Increased Left Ventricular Trabeculation in Athletes - a Marker of Left Ventricular Non-compaction or a Physiological Epiphenomenon of Increased Cardiac Preload?	Completed	NCT02568072
5	International Consortium for Multimodality Phenotyping in Adults With Non-compaction	Not yet recruiting	NCT04424030
6	Analysis of Cardiac Biomarkers, Electrocardiograms and Cardio-pulmonary Exercise Test (CPET) Results in Children With Dilated (DCM), Hypertrophic (HCM) and Left-ventricle Non-compaction (LVNC) Cardiomyopathies	Not yet recruiting	NCT04316923

Search NIH Clinical Center for Left Ventricular Noncompaction

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Genetic Tests for Left Ventricular Noncompaction

Genetic tests related to Left Ventricular Noncompaction:

#	Genetic test	Affiliating Genes
1	Left Ventricular Noncompaction ²⁹

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Anatomical Context for Left Ventricular Noncompaction

MalaCards organs/tissues related to Left Ventricular Noncompaction:

⁴⁰

Heart, Kidney, Skeletal Muscle

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Publications for Left Ventricular Noncompaction

Articles related to Left Ventricular Noncompaction:

(show top 50) (show all 959)

#	Title	Authors	PMID	Year
1	Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation. ⁶ ⁶¹	Cao Q...Hong K	29118297	2017
2	Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. ⁶¹ ⁶	Arndt AK...Klaassen S	23768516	2013
3	Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. ⁶ ⁶¹	Luxan G...de la Pompa JL	23314057	2013
4	Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype. ⁶¹ ⁶	Probst S...Klaassen S	21551322	2011
5	Mutations in sarcomere protein genes in left ventricular noncompaction. ⁶¹ ⁶	Klaassen S...Thierfelder L	18506004	2008
6	Genetic analysis in patients with left ventricular noncompaction and evidence for genetic heterogeneity. ⁶¹ ⁶	Xing Y...Towbin JA	16427346	2006
7	Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. ⁶¹ ⁶	Ichida F...Towbin JA	11238270	2001
8	Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. ⁶	Luedde M...Frey N	20083571	2010
9	Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy. ⁶	Hershberger RE...Gonzalez-Quintana J	20215591	2010
10	Cardiac troponin T mutation in familial cardiomyopathy with variable remodeling and restrictive physiology. ⁶	Menon SC...Olson TM	18651846	2008
11	Shared genetic causes of cardiac hypertrophy in children and adults. ⁶	Morita H...Seidman CE	18403758	2008
12	Echocardiographic-determined septal morphology in Z-disc hypertrophic cardiomyopathy. ⁶	Theis JL...Ackerman MJ	17097056	2006
13	Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype. ⁶	Mirza M...Watkins H	15923195	2005
14	Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. ⁶	Van Driest SL...Ackerman MJ	15519027	2004
15	Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. ⁶	Mogensen J...McKenna WJ	15542288	2004
16	A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. ⁶	Arimura T...Kimura A	14660611	2004
17	Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. ⁶	Vatta M...Towbin JA	14662268	2003
18	Identification of the genotypes causing hypertrophic cardiomyopathy in northern Sweden. ⁶	Morner S...Waldenstrom A	12818575	2003
19	Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. ⁶	Daehmlow S...Regitz-Zagrosek V	12379228	2002
20	Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy. ⁶	Li D...Roberts R	11684629	2001
21	Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy. ⁶	Olson TM...Michels VV	11273725	2001
22	Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. ⁶	Kamisago M...Seidman CE	11106718	2000
23	Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. ⁶	Olson TM...Keating MT	9563954	1998
24	Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. ⁶	Thierfelder L...Seidman CE	8205619	1994
25	Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q. ⁶	Townsend PJ...Barton PJ	8088824	1994
26	Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide. ⁶¹	Sabbah HN	33001359	2021
27	Cardiac complications in inherited mitochondrial diseases. ⁶¹	Behjati M...Nejati M	32728985	2021
28	Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction. ⁶¹	Szucs A...Vago H	33577906	2021
29	Congenital atresia of the left main coronary artery with left ventricular noncompaction: From infancy to adulthood. ⁶¹	Qiu YG...Zhao JH	33583822	2021
30	Additional information on our report: Trabeculectomy for left ventricular noncompaction. ⁶¹	Takamatsu M...Kamohara K	33581163	2021
31	The genetics of left ventricular noncompaction. ⁶¹	Cannie D...Elliott P	33605617	2021
32	Genetic Association Between Hypoplastic Left Heart Syndrome and Cardiomyopathies. ⁶¹	Theis JL...Olson TM	33325730	2021
33	Long-Term Survival of Patients With Left Ventricular Noncompaction. ⁶¹	Vaidya VR...Melduni RM	33441029	2021
34	The value of cardiac magnetic resonance imaging and programmed ventricular stimulation in patients with ventricular noncompaction and ventricular arrhythmias. ⁶¹	Gunda S...Bogun F	33442886	2021
35	Arrhythmic risk stratification in left ventricular noncompaction. ⁶¹	Peretto G	33442920	2021
36	Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies. ⁶¹	Mazzarotto F...Walsh R	33500567	2021
37	RBM20-Associated Ventricular Arrhythmias in a Patient with Structurally Normal Heart. ⁶¹	Vakhrushev Y...Kostareva A	33450993	2021
38	A novel HCN4 variant related to familial sinus bradycardia, left ventricular noncompaction, and thoracic aortic aneurysm. ⁶¹	Poninska J...Bilinska ZT	33185997	2021
39	Left Ventricular Noncompaction Cardiomyopathy: New Clues in a Not So New Disease? ⁶¹	Jefferies JL	33442993	2021
40	Catheter ablation of ventricular arrhythmias in left ventricular noncompaction cardiomyopathy. ⁶¹	Sanchez Munoz JJ...Alberola AG	33346135	2020
41	[Clinical pathway for cardiomyopathies: a genetic testing strategy proposed by ANMCO in Tuscany]. ⁶¹	Girolami F...Casolo G	33231212	2020
42	A burden of sarcomere gene variants in fetal-onset patients with left ventricular noncompaction. ⁶¹	Hirono K...for LVNC study collaborators	33309763	2020
43	Diagnosis of Double-chambered Left Ventricle of Superior-inferior Type by Echocardiography: A Retrospective Study of 9 Subjects across Two Heart Centers. ⁶¹	Bao SF...Wang Q	33368575	2020
44	Effect of Noncompacted Myocardial Resection on Isolated Left Ventricular Noncompaction. ⁶¹	Takamatsu M...Koga Y	32360189	2020
45	Late gadolinium enhancement on CMRI in patients with LV noncompaction: An overestimated phenomenon? ⁶¹	Asmakutlu O...Sahin A	32480266	2020
46	Expanding the Clinical Phenotype of Emerinopathies: Atrial Standstill and Left Ventricular Noncompaction. ⁶¹	Gollob MH	33079577	2020
47	Genetic architecture of left ventricular noncompaction in adults. ⁶¹	Ross SB...Semsarian C	33419992	2020
48	Association Between Left Ventricular Noncompaction and Vigorous Physical Activity. ⁶¹	de la Chica JA...Fuster V	33032733	2020
49	Left Ventricular Noncompaction and Vigorous Physical Activity: What Is the Connection? ⁶¹	Towbin JA...Beasley G	33032734	2020
50	Prevalence of left ventricular hypertrabeculation/noncompaction among patients with congenital dyserythropoietic anemia Type 1 (CDA1). ⁶¹	Abramovich-Yoffe H...Levitas A	32512057	2020

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Genes for Left Ventricular Noncompaction

Genes related to Left Ventricular Noncompaction (23 elite genes):

(show top 50) (show all 117)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MYH7	Myosin Heavy Chain 7	Protein Coding	802.82	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	11106718
2	TNNT2	Troponin T2, Cardiac Type	Protein Coding	802.32	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	8205619 18651846
3	TPM1	Tropomyosin 1	Protein Coding	799.81	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	11273725
4	PRDM16	PR/SET Domain 16	Protein Coding	766.18	Pathogenic ⁶ Causative germline mutation ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)	23768516
5	DTNA	Dystrobrevin Alpha	Protein Coding	487.63	Pathogenic ⁶ Likely pathogenic ⁶ Candidate gene tested ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Variants (show sections)	11238270
6	MYBPC3	Myosin Binding Protein C3	Protein Coding	477.98	Pathogenic ⁶ Likely pathogenic ⁶ Candidate gene tested ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	12379228
7	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	476.43	Pathogenic ⁶ Likely pathogenic ⁶ Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	9563954
8	LMNA	Lamin A/C	Protein Coding	473.89	Pathogenic ⁶ Likely pathogenic ⁶ Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
9	LDB3	LIM Domain Binding 3	Protein Coding	451.16	Pathogenic ⁶ Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	14662268
10	TTN	Titin	Protein Coding	449.63	Pathogenic ⁶ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
11	RBM20	RNA Binding Motif Protein 20	Protein Coding	439.37	Pathogenic ⁶ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
12	TTN-AS1	TTN Antisense RNA 1	RNA Gene	433.11	Pathogenic ⁶ Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)
13	DES	Desmin	Protein Coding	432.21	Pathogenic ⁶ Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)
14	MIPEP	Mitochondrial Intermediate Peptidase	Protein Coding	412.29	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
15	NKX2-5	NK2 Homeobox 5	Protein Coding	406.83	Pathogenic ⁶ DISEASES inferred ¹⁵
16	C1QTNF9	C1q And TNF Related 9	Protein Coding	400	Pathogenic ⁶
17	MADD	MAP Kinase Activating Death Domain	Protein Coding	400	Pathogenic ⁶
18	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	398.99	Causative germline mutation (loss of function) ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	23314057
19	PKP2	Plakophilin 2	Protein Coding	389.62	Causative germline mutation ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
20	MYH7B	Myosin Heavy Chain 7B	Protein Coding	355.34	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁵
21	LVNC2	Noncompaction Of Left Ventricular Myocardium, Familial Isolated, Autosomal Dominant 2	Genetic Locus	57.1	MalaCards inferred ⁴⁰ GeneCards inferred via : Publications (show sections)
22	PLEKHM2	Pleckstrin Homology And RUN Domain Containing M2	Protein Coding	48.05	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
23	NEXN	Nexilin F-Actin Binding Protein	Protein Coding	37.2	Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
24	TNNC1	Troponin C1, Slow Skeletal And Cardiac Type	Protein Coding	37.04	Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
25	TAZ	Tafazzin	Protein Coding	36.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Variants (show sections)
26	LOC110121269	VISTA Enhancer Hs2177	Biological Region	32.21	Risk factor ⁶ GeneCards inferred via : Variants (show sections)
27	MYL2	Myosin Light Chain 2	Protein Coding	31.37	Likely pathogenic ⁶ DISEASES inferred ¹⁵
28	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	30.34	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵
29	SLC30A5	Solute Carrier Family 30 Member 5	Protein Coding	25	Likely pathogenic ⁶
30	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	24.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
31	RYR2	Ryanodine Receptor 2	Protein Coding	23.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
32	ACTN2	Actinin Alpha 2	Protein Coding	23.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
33	HCN4	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4	Protein Coding	23.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
34	MYH6	Myosin Heavy Chain 6	Protein Coding	16.2	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
35	DSP	Desmoplakin	Protein Coding	14.26	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
36	MYPN	Myopalladin	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
37	JUP	Junction Plakoglobin	Protein Coding	13.62	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
38	CSRP3	Cysteine And Glycine Rich Protein 3	Protein Coding	13.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
39	TBX5	T-Box Transcription Factor 5	Protein Coding	13.43	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
40	TCAP	Titin-Cap	Protein Coding	13.43	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
41	DMD	Dystrophin	Protein Coding	13.38	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
42	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
43	OBSCN	Obscurin, Cytoskeletal Calmodulin And Titin-Interacting RhoGEF	Protein Coding	13.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
44	DSG2	Desmoglein 2	Protein Coding	13.12	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
45	JPH2	Junctophilin 2	Protein Coding	13.1	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
46	MYLK2	Myosin Light Chain Kinase 2	Protein Coding	13.08	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
47	BAG3	BAG Cochaperone 3	Protein Coding	12.98	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
48	TMEM43	Transmembrane Protein 43	Protein Coding	12.85	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
49	KCNQ1	Potassium Voltage-Gated Channel Subfamily Q Member 1	Protein Coding	12.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
50	SNTA1	Syntrophin Alpha 1	Protein Coding	12.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Left Ventricular Noncompaction

ClinVar genetic disease variations for Left Ventricular Noncompaction:

⁶ (show top 50) (show all 1287)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	LDB3	NM_007078.3(LDB3):c.1035C>G (p.Ile345Met)	SNV	Pathogenic	4730	rs121908336	10:88466426-88466426	10:86706669-86706669
2	LDB3	NM_007078.3(LDB3):c.617C>T (p.Thr206Ile)	SNV	Pathogenic	4732	rs121908337	10:88441488-88441488	10:86681731-86681731
3	LDB3	NM_007078.3(LDB3):c.690-4789A>T	SNV	Pathogenic	4734	rs121908339	10:88446864-88446864	10:86687107-86687107
4	LDB3	NM_007078.3(LDB3):c.2017G>A (p.Asp673Asn)	SNV	Pathogenic	4735	rs45514002	10:88485932-88485932	10:86726175-86726175
5	DTNA	NM_001390.4(DTNA):c.362C>T (p.Pro121Leu)	SNV	Pathogenic	8306	rs104894654	18:32374214-32374214	18:34794250-34794250
6	TNNT2	NM_001276345.2(TNNT2):c.266T>A (p.Ile89Asn)	SNV	Pathogenic	12408	rs121964855	1:201334766-201334766	1:201365638-201365638
7	TNNT2	NM_001276345.2(TNNT2):c.451C>T (p.Arg151Trp)	SNV	Pathogenic	12414	rs74315379	1:201333464-201333464	1:201364336-201364336
8	TNNT2	NM_001276345.2(TNNT2):c.421C>T (p.Arg141Trp)	SNV	Pathogenic	12415	rs74315380	1:201333494-201333494	1:201364366-201364366
9	TNNT2	NM_001276345.2(TNNT2):c.644G>T (p.Arg215Leu)	SNV	Pathogenic	12416	rs121964860	1:201331116-201331116	1:201361988-201361988
10	TNNT2	NM_001276345.2(TNNT2):c.838G>A (p.Asp280Asn)	SNV	Pathogenic	12417	rs121964861	1:201328764-201328764	1:201359636-201359636
11	TPM1	NM_001018005.2(TPM1):c.160G>A (p.Glu54Lys)	SNV	Pathogenic	12458	rs104894505	15:63336271-63336271	15:63044072-63044072
12	TPM1	NM_001018005.2(TPM1):c.118G>A (p.Glu40Lys)	SNV	Pathogenic	12459	rs104894501	15:63336229-63336229	15:63044030-63044030
13	MYH7	NM_000257.4(MYH7):c.1594T>C (p.Ser532Pro)	SNV	Pathogenic	14108	rs121913642	14:23897088-23897088	14:23427879-23427879
14	MYH7	NM_000257.4(MYH7):c.2292C>G (p.Phe764Leu)	SNV	Pathogenic	14109	rs121913643	14:23894622-23894622	14:23425413-23425413
15	MYH7	NM_000257.4(MYH7):c.667G>A (p.Ala223Thr)	SNV	Pathogenic	14112	rs121913645	14:23900859-23900859	14:23431650-23431650
16	MYH7	NM_000257.4(MYH7):c.1925C>T (p.Ser642Leu)	SNV	Pathogenic	14113	rs121913646	14:23896480-23896480	14:23427271-23427271
17	TTN	NM_001267550.2(TTN):c.20836+1G>A	SNV	Pathogenic	523428	rs1553915256	2:179590094-179590094	2:178725367-178725367
18	MYH7	NM_000257.4(MYH7):c.1106G>A (p.Arg369Gln)	SNV	Pathogenic	42822	rs397516089	14:23899016-23899016	14:23429807-23429807
19	TNNT2	NM_001276345.2(TNNT2):c.650_652AGA[3] (p.Lys220del)	Microsatellite	Pathogenic	43659	rs45578238	1:201331099-201331101	1:201361971-201361973
20	PRDM16	NM_022114.4(PRDM16):c.2104A>T (p.Lys702Ter)	SNV	Pathogenic	60724	rs397514742	1:3328865-3328865	1:3412301-3412301
21	PRDM16	PRDM16, 1-BP DUP, 1573C	Duplication	Pathogenic	60725
22	PRDM16	NM_022114.4(PRDM16):c.2447A>G (p.Asn816Ser)	SNV	Pathogenic	60726	rs397514743	1:3329208-3329208	1:3412644-3412644
23	TNNT2	NM_001276345.2(TNNT2):c.316G>A (p.Glu106Lys)	SNV	Pathogenic	224775	rs869312881	1:201334414-201334414	1:201365286-201365286
24	MYH7	NM_000257.4(MYH7):c.732+1G>A	SNV	Pathogenic	14127	rs730880850	14:23900793-23900793	14:23431584-23431584
25	MYH7	NM_000257.4(MYH7):c.842G>C (p.Arg281Thr)	SNV	Pathogenic	181327	rs730880856	14:23900163-23900163	14:23430954-23430954
26	MYH7	NM_000257.4(MYH7):c.1157A>G (p.Tyr386Cys)	SNV	Pathogenic	164378	rs727503269	14:23898538-23898538	14:23429329-23429329
27	MYH7	NM_000257.4(MYH7):c.1573G>A (p.Glu525Lys)	SNV	Pathogenic	132925	rs606231324	14:23897714-23897714	14:23428505-23428505
28	TNNT2	NM_001276345.2(TNNT2):c.311G>A (p.Arg104His)	SNV	Pathogenic	43628	rs397516457	1:201334419-201334419	1:201365291-201365291
29	TNNT2	NM_001276345.2(TNNT2):c.548G>A (p.Arg183Gln)	SNV	Pathogenic	43649	rs397516471	1:201332476-201332476	1:201363348-201363348
30	TNNT2	NM_001276345.2(TNNT2):c.508_510GAG[3] (p.Glu173del)	Microsatellite	Pathogenic	43648	rs397516470	1:201332505-201332507	1:201363377-201363379
31	TNNT2	NM_001276345.2(TNNT2):c.644G>A (p.Arg215Gln)	SNV	Pathogenic	165539	rs121964860	1:201331116-201331116	1:201361988-201361988
32	TNNT2	NM_001276345.2(TNNT2):c.418C>T (p.Arg140Cys)	SNV	Pathogenic	43636	rs397516463	1:201333497-201333497	1:201364369-201364369
33	TNNT2	NM_001276345.2(TNNT2):c.311G>T (p.Arg104Leu)	SNV	Pathogenic	43629	rs397516457	1:201334419-201334419	1:201365291-201365291
34	TNNT2	NM_001276345.2(TNNT2):c.566C>T (p.Ser189Phe)	SNV	Pathogenic	177634	rs727504246	1:201332458-201332458	1:201363330-201363330
35	TNNT2	NM_001276345.2(TNNT2):c.304C>T (p.Arg102Trp)	SNV	Pathogenic	43627	rs397516456	1:201334426-201334426	1:201365298-201365298
36	TNNT2	NM_001276345.2(TNNT2):c.547C>T (p.Arg183Trp)	SNV	Pathogenic	228409	rs727503512	1:201332477-201332477	1:201363349-201363349
37	RBM20	NM_001134363.3(RBM20):c.1913C>T (p.Pro638Leu)	SNV	Pathogenic	268	rs267607003	10:112572068-112572068	10:110812310-110812310
38	LMNA	NM_170707.4(LMNA):c.904_905CT[2] (p.Ser303fs)	Microsatellite	Pathogenic	66955	rs59684335	1:156105071-156105072	1:156135280-156135281
39	DES	NM_001927.4(DES):c.1333_1336del (p.Lys444_Thr445insTer)	Deletion	Pathogenic	265807	rs1114167327	2:220290428-220290431	2:219425706-219425709
40	DES	NM_001927.4(DES):c.493_520delinsGCGT (p.Gln165_Ala174delinsAlaSer)	Indel	Pathogenic	265817	rs1114167332	2:220283677-220283704	2:219418955-219418982
41	LMNA	NM_170707.4(LMNA):c.568C>T (p.Arg190Trp)	SNV	Pathogenic	66908	rs59026483	1:156104248-156104248	1:156134457-156134457
42	MYH7	NM_000257.4(MYH7):c.1987C>T (p.Arg663Cys)	SNV	Pathogenic	42874	rs397516127	14:23896043-23896043	14:23426834-23426834
43	TNNT2	NM_001276345.2(TNNT2):c.421C>T (p.Arg141Trp)	SNV	Pathogenic	12415	rs74315380	1:201333494-201333494	1:201364366-201364366
44	TNNT2	NM_001276345.2(TNNT2):c.451C>T (p.Arg151Trp)	SNV	Pathogenic	12414	rs74315379	1:201333464-201333464	1:201364336-201364336
45	TNNT2	NM_001276345.2(TNNT2):c.650_652AGA[3] (p.Lys220del)	Microsatellite	Pathogenic	43659	rs45578238	1:201331099-201331101	1:201361971-201361973
46	TNNT2	NM_001276345.2(TNNT2):c.446G>A (p.Arg149His)	SNV	Pathogenic	43642	rs397516466	1:201333469-201333469	1:201364341-201364341
47	TNNT2	NM_001276345.2(TNNT2):c.310C>T (p.Arg104Cys)	SNV	Pathogenic	165549	rs727503513	1:201334420-201334420	1:201365292-201365292
48	MYH7	NM_000257.4(MYH7):c.1573G>A (p.Glu525Lys)	SNV	Pathogenic	132925	rs606231324	14:23897714-23897714	14:23428505-23428505
49	MIPEP	NM_005932.4(MIPEP):c.1804G>T (p.Glu602Ter)	SNV	Pathogenic	208631	rs114638163	13:24380133-24380133	13:23805994-23805994
50	C1QTNF9	GRCh37/hg19 13q12.12(chr13:23519916-24941516)x1	copy number loss	Pathogenic	208634		13:23519916-24941516

Sources

Expression for Left Ventricular Noncompaction

Search GEO for disease gene expression data for Left Ventricular Noncompaction.

Sources

Pathways for Left Ventricular Noncompaction

Pathways related to Left Ventricular Noncompaction according to KEGG:

³⁶

#	Name	Kegg Source Accession
1	Cardiac muscle contraction	hsa04260

Pathways related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁵ Show member pathways Classical Kir channels ⁶⁵ Ion homeostasis ⁶⁵ Ion transport by P-type ATPases ⁶⁵ Muscle contraction ⁶⁵ Phase 1 - inactivation of fast Na+ channels ⁶⁵ Phase 3 - rapid repolarisation ⁶⁵ Phase 4 - resting membrane potential ⁶⁵ Physiological factors ⁶⁵ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁵ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁵ Tandem pore domain potassium channels ⁶⁵ TWIK related potassium channel (TREK) ⁶⁵ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁵ TWIK-related spinal cord K+ channel (TRESK) ⁶⁵ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁵	12.53	TTN TPM1 TNNT2 NKX2-5 MYBPC3 DES
2	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.28	TPM1 TNNT2 MYH7 ACTC1
3	Cytoskeletal Signaling ⁴	12.25	TPM1 TNNT2 LMNA DES ACTC1
4	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.61	TNNT2 NKX2-5 DES
5	Dilated cardiomyopathy ³⁶ Show member pathways Hypertrophic cardiomyopathy ³⁶	11.49	TTN TPM1 TNNT2 MYH7 MYBPC3 LMNA
6	Cardiac muscle contraction ³⁶	11.4	TPM1 TNNT2 MYH7 ACTC1
7	Cardiac Progenitor Differentiation ¹	11.3	TNNT2 NKX2-5 ACTC1
8	Striated Muscle Contraction ⁶⁵ ¹	11.29	TTN TPM1 TNNT2 MYBPC3 DES ACTC1
9	Cardiomyocyte Differentiation through BMP Receptors ⁶³	10.78	NKX2-5 MYH7B MYH7
10	HOP Signaling ⁶³	10.21	NKX2-5 ACTC1

Sources

GO Terms for Left Ventricular Noncompaction

Cellular components related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Z disc	GO:0030018	9.56	TTN MYH7 LDB3 DES
2	stress fiber	GO:0001725	9.5	TPM1 MYH7 LDB3
3	striated muscle thin filament	GO:0005865	9.37	TTN TNNT2
4	sarcomere	GO:0030017	9.35	TPM1 TNNT2 MYH7 MYBPC3 ACTC1
5	myosin filament	GO:0032982	9.33	MYH7B MYH7 MYBPC3
6	cardiac myofibril	GO:0097512	8.92	TNNT2 MYH7B MYBPC3 DES

Biological processes related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	heart development	GO:0007507	9.83	RBM20 PKP2 NKX2-5 MIB1 LDB3
2	muscle contraction	GO:0006936	9.72	TTN TPM1 TNNT2 MYH7 DES
3	positive regulation of ATPase activity	GO:0032781	9.65	TPM1 TNNT2 MYBPC3
4	regulation of heart contraction	GO:0008016	9.63	TPM1 TNNT2 DES
5	striated muscle contraction	GO:0006941	9.58	TTN MYH7 DTNA
6	regulation of muscle contraction	GO:0006937	9.56	TPM1 TNNT2
7	sarcomere organization	GO:0045214	9.56	TTN TPM1 TNNT2 LDB3
8	positive regulation of sodium ion transport	GO:0010765	9.55	PKP2 NKX2-5
9	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.55	TPM1 TNNT2 PKP2 MYH7 MYBPC3
10	adult heart development	GO:0007512	9.54	NKX2-5 MYH7
11	cardiac muscle tissue morphogenesis	GO:0055008	9.54	TTN NKX2-5 ACTC1
12	cardiac myofibril assembly	GO:0055003	9.52	TTN ACTC1
13	ventricular cardiac muscle cell development	GO:0055015	9.51	NKX2-5 LMNA
14	cardiac muscle contraction	GO:0060048	9.5	TTN TPM1 TNNT2 NKX2-5 MYH7 MYBPC3
15	skeletal muscle thin filament assembly	GO:0030240	9.49	TTN ACTC1
16	muscle filament sliding	GO:0030049	9.17	TTN TPM1 TNNT2 MYH7 MYBPC3 DES

Molecular functions related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.91	TTN TPM1 TNNT2 MYBPC3 LMNA DES
2	actin filament binding	GO:0051015	9.46	TTN TPM1 MYH7B MYH7
3	cytoskeletal protein binding	GO:0008092	9.43	TPM1 LDB3 DES
4	muscle alpha-actinin binding	GO:0051371	9.32	TTN LDB3
5	structural constituent of muscle	GO:0008307	9.13	TTN TPM1 MYBPC3
6	actin binding	GO:0003779	9.1	TPM1 TNNT2 MYH7B MYH7 MYBPC3 LDB3

Sources

Sources for Left Ventricular Noncompaction

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Left Ventricular Noncompaction (LVHT)

Aliases & Classifications for Left Ventricular Noncompaction

MalaCards integrated aliases for Left Ventricular Noncompaction:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Left Ventricular Noncompaction

Related Diseases for Left Ventricular Noncompaction

Diseases in the Left Ventricular Noncompaction family:

Diseases related to Left Ventricular Noncompaction via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Left Ventricular Noncompaction:

Symptoms & Phenotypes for Left Ventricular Noncompaction

MGI Mouse Phenotypes related to Left Ventricular Noncompaction:

Drugs & Therapeutics for Left Ventricular Noncompaction

Interventional clinical trials:

Genetic Tests for Left Ventricular Noncompaction

Genetic tests related to Left Ventricular Noncompaction:

Anatomical Context for Left Ventricular Noncompaction

MalaCards organs/tissues related to Left Ventricular Noncompaction:

Publications for Left Ventricular Noncompaction

Articles related to Left Ventricular Noncompaction:

Genes for Left Ventricular Noncompaction

Genes related to Left Ventricular Noncompaction (23 elite genes):

Variations for Left Ventricular Noncompaction

ClinVar genetic disease variations for Left Ventricular Noncompaction:

Expression for Left Ventricular Noncompaction

Pathways for Left Ventricular Noncompaction

Pathways related to Left Ventricular Noncompaction according to KEGG:

Pathways related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

GO Terms for Left Ventricular Noncompaction

Cellular components related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Biological processes related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Molecular functions related to Left Ventricular Noncompaction according to GeneCards Suite gene sharing:

Sources for Left Ventricular Noncompaction